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Urethral reconstruction

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https://www.readbyqxmd.com/read/28913706/novel-pericatheter-retrograde-urethrogram-technique-is-a-viable-method-for-postoperative-urethroplasty-imaging
#1
Rachael D Sussman, F Cameron Hill, George E Koch, Versha Patel, Krishnan Venkatesan
PURPOSE: The purpose of this study is to describe our technique for pericatheter retrograde urethrogram (pcRUG) and to evaluate the utility of a pcRUG to detect a clinically significant leak after urethral reconstruction. METHODS: We retrospectively reviewed our prospective IRB-approved database of patients undergoing urethral reconstruction. pcRUG was performed at 3-4 weeks after surgery, in standardized fashion. Patients were placed in oblique position, and with the penis stretched, diluted contrast was instilled via an angiocatheter alongside the indwelling urethral catheter under dynamic fluoroscopy...
September 14, 2017: International Urology and Nephrology
https://www.readbyqxmd.com/read/28899606/is-tissue-engineering-of-patient-specific-oral-mucosa-grafts-the-future-of-urethral-reconstruction
#2
Hans M Larsson
No abstract text is available yet for this article.
September 8, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28893083/tissue-engineering-of-urethra-systematic-review-of-recent-literature
#3
Stanislav Žiaran, Martina Galambošová, L'uboš Danišovič
The purpose of this article was to perform a systematic review of the recent literature on urethral tissue engineering. A total of 31 articles describing the use of tissue engineering for urethra reconstruction were included. The obtained results were discussed in three groups: cells, scaffolds, and clinical results of urethral reconstructions using these components. Stem cells of different origin were used in many experimental studies, but only autologous urothelial cells, fibroblasts, and keratinocytes were applied in clinical trials...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/28888708/ureteric-urethral-engraftment-as-a-new-surgical-technique-for-management-of-incontinence-in-bladder-exstrophy-complex-a-retrospective-cohort
#4
Abdol-Mohammad Kajbafzadeh, Shabnam Sabetkish, Nastaran Sabetkish
OBJECTIVES: To report the results of a novel surgical technique for achieving urinary continence in patients with bladder exstrophy complex (BEC) by ureteric-urethral engraftment (UUE) technique. PATIENTS AND METHODS: Sixteen female patients with BEC and a mean ± SD age of 3.48 ± 1.75 years were referred for primary exstrophy repair from 2009 to 2012. From these, 9 patients were operated by single-stage bladder closure (group I); while 7 patients underwent the novel technique of UUE to compare the continence achievement (group II)...
September 6, 2017: International Journal of Surgery
https://www.readbyqxmd.com/read/28866465/three-dimensional-computerized-model-based-on-the-sonourethrogram-a-novel-technique-for-evaluating-the-anterior-urethral-stricture
#5
Lei Chen, Chao Feng, Xiang-Guo Lv, Hai-Hao Fan, Pankaj Joshi, Guido Barbagli, Yu-Min Zhao, Yue-Min Xu, Zhe Li, Bing Hu, Qiang Fu
PURPOSE: The sonourethrogram is a useful alternative to the traditional retrograde urethrogram (RUG) for evaluating anterior urethral stricture. With the development of three-dimensional (3-D) reconstructive technique, 3-D urethral image can provide more accurate and useful information to allow the surgeon make the best surgical decision. The purpose of this study is to evaluate the accuracy and efficacy of a 3-D reconstructed digital model of the urethra based on the sonourethrogram for assessing anterior urethral disease...
August 30, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28865886/posterior-hypospadias-evaluation-of-a-paradigm-shift-from-single-to-staged-repair
#6
H Badawy, S Orabi, A Hanno, H Abdelhamid
INTRODUCTION: Repair of posterior hypospadias is a current dilemma. Single versus staged repair is the main question to answer. The answer is not easily reached due to lack of comparative studies. Hence such studies are not available, the reports of a change from one approach to the other one are important to point out the results of each procedure in the same hands and in the same center. Herein, we report our results of the repair of posterior hypospadias shifting from single stage to staged repair...
August 9, 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/28831521/-redo-urethroplasty-with-buccal-mucosa
#7
REVIEW
C M Rosenbaum, L Ernst, O Engel, R Dahlem, M Fisch, L A Kluth
Urethral strictures can occur on the basis of trauma, infections, iatrogenic-induced or idiopathic and have a great influence on the patient's quality of life. The current prevalence rate of male urethral strictures is 0.6% in industrialized western countries. The favored form of treatment has experienced a transition from less invasive interventions, such as urethrotomy or urethral dilatation, to more complex open surgical reconstruction. Excision and primary end-to-end anastomosis and buccal mucosa graft urethroplasty are the most frequently applied interventions with success rates of more than 80%...
August 22, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28830642/vector-flow-visualization-of-urinary-flow-dynamics-in%C3%A2-a%C3%A2-bladder-outlet-obstruction-model
#8
Takuro Ishii, Billy Y S Yiu, Alfred C H Yu
Voiding dysfunction that results from bladder outlet (BO) obstruction is known to alter significantly the dynamics of urine passage through the urinary tract. To non-invasively image this phenomenon on a time-resolved basis, we pursued the first application of a recently developed flow visualization technique called vector projectile imaging (VPI) that can track the spatiotemporal dynamics of flow vector fields at a frame rate of 10,000 fps (based on plane wave excitation and least-squares Doppler vector estimation principles)...
August 19, 2017: Ultrasound in Medicine & Biology
https://www.readbyqxmd.com/read/28827108/delayed-reconstruction-of-bulbar-urethral-strictures-is-associated-with-multiple-interventions-longer-strictures-and-more-complex-repairs
#9
Boyd R Viers, Travis J Pagliara, Nabeel A Shakir, Charles A Rew, Lauren Folgosa-Cooley, Jeremy M Scott, Allen F Morey
PURPOSE: Prior to urethral reconstruction, many stricture patients undergo a variable period during which endoscopic treatments are employed for recurrent obstructive symptoms. We evaluate the association between urethroplasty delay, endoscopic treatments, and subsequent reconstructive outcomes. MATERIALS AND METHODS: We reviewed men undergoing primary bulbar urethroplasty from 2007-2014. Prior urethroplasty, penile and/or membranous strictures, and cases with incomplete data were excluded...
August 18, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28827035/results-of-use-of-tissue-engineered-autologous-oral-mucosa-graft-for-urethral-reconstruction-a-multicenter-prospective-observational-trial
#10
Gouya Ram-Liebig, Guido Barbagli, Axel Heidenreich, Dirk Fahlenkamp, Giuseppe Romano, Udo Rebmann, Diana Standhaft, Hermann van Ahlen, Samer Schakaki, Ulf Balsmeyer, Maria-Elsa Spiegeler, Helmut Knispel
BACKGROUND: Harvest of oral mucosa for urethroplasty due to urethral stricture is associated with donor-site-morbidity. We assessed functionality and safety of an authorized tissue-engineered oral mucosa graft (TEOMG) under routine practice in stricture recurrences of any etiology, location, length and severity (real-world data). METHODS: 99 patients from eight centers with heterogenous urethroplasty experience levels were included in this prospective, non-interventional observational study...
August 16, 2017: EBioMedicine
https://www.readbyqxmd.com/read/28813673/multipotent-basal-stem-cells-maintained-in-localized-proximal-niches-support-directed-long-ranging-epithelial-flows-in-human-prostates
#11
Mohammad Moad, Edouard Hannezo, Simon J Buczacki, Laura Wilson, Amira El-Sherif, David Sims, Robert Pickard, Nicholas A Wright, Stuart C Williamson, Doug M Turnbull, Robert W Taylor, Laura Greaves, Craig N Robson, Benjamin D Simons, Rakesh Heer
Sporadic mitochondrial DNA mutations serve as clonal marks providing access to the identity and lineage potential of stem cells within human tissues. By combining quantitative clonal mapping with 3D reconstruction of adult human prostates, we show that multipotent basal stem cells, confined to discrete niches in juxta-urethral ducts, generate bipotent basal progenitors in directed epithelial migration streams. Basal progenitors are then dispersed throughout the entire glandular network, dividing and differentiating to replenish the loss of apoptotic luminal cells...
August 15, 2017: Cell Reports
https://www.readbyqxmd.com/read/28805298/female-urethral-injuries-associated-with-pelvic-fracture-a-systematic-review-of-the-literature
#12
REVIEW
Devin N Patel, Cynthia S Fok, George D Webster, Jennifer T Anger
OBJECTIVES: To systematically review the literature of female urethral injuries associated with pelvic fracture and determine optimal management of this rare injury. MATERIALS AND METHODS: Using Meta-analysis Of Observational Studies in Epidemiology criteria, we searched Cochrane, Pubmed and OVID databases for all articles available before June 30, 2016 using the terms "female pelvic fracture urethroplasty," "female urethral distraction," "female pelvic fracture urethral injury," "female pelvic fracture urethra girls...
August 14, 2017: BJU International
https://www.readbyqxmd.com/read/28791228/management-of-bladder-neck-stenosis-and-urethral-stricture-and-stenosis-following-treatment-for-prostate-cancer
#13
REVIEW
Helen L Nicholson, Yasser Al-Hakeem, Javier J Maldonado, Vincent Tse
The aim of this review is to examine all urethral strictures and stenoses subsequent to treatment for prostate cancer, including radical prostatectomy (RP), radiotherapy, high intensity focused ultrasound (HIFU) and cryotherapy. The overall majority respond to endoscopic treatment, including dilatation, direct visual internal urethrotomy (DVIU) or bladder neck incision (BNI). There are adjunct treatments to endoscopic management, including injections of corticosteroids and mitomycin C (MMC) and urethral stents, which remain controversial and are not currently mainstay of treatment...
July 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28791225/surgical-management-of-female-urethral-strictures
#14
REVIEW
Nathan Hoag, Justin Chee
Female urethral stricture (FUS) represents a rare condition, yet one that can cause significant, bothersome lower urinary tract symptoms (LUTS). Historically, urethral dilation has been a preferred treatment choice for these patients. A variety of reconstructive surgical techniques have been described in recent years to provide more definitive management in this challenging group of patients. We present an overview of FUS and a summary of surgical management options.
July 2017: Translational Andrology and Urology
https://www.readbyqxmd.com/read/28776126/management-of-urethral-stricture-and-bladder-neck-contracture-following-primary-and-salvage-treatment-of-prostate-cancer
#15
REVIEW
Brendan Michael Browne, Alex J Vanni
PURPOSE OF REVIEW: This article discusses the incidence, evaluation, and treatment of bladder outlet obstruction from urethral stricture, vesicourethral anastomotic stricture, and bladder neck contracture following primary and salvage treatment of prostate cancer. RECENT FINDINGS: Rates of stenosis after prostate cancer treatment appear similar across all primary treatment modalities including radical prostatectomy, radiation therapy, cryoablation, and high-intensity focused ultrasound in contemporary series...
October 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28755966/characteristics-of-idiopathic-urethral-strictures-a-link-to-remote-perineal-trauma
#16
Boyd R Viers, Travis J Pagliara, Charles A Rew, Lauren Folgosa Cooley, Christine Y Shiang, Jeremy M Scott, Allen F Morey
OBJECTIVE: To characterize the physical features and reconstructive outcomes of a series of idiopathic urethral stricture (IUS) cases in an effort to elucidate the nature of this common, yet poorly understood entity. METHODS: We retrospectively reviewed our urethroplasty database to identify men undergoing initial urethral reconstruction from 2007-2014 at one of three hospitals (N=514). Patients were stratified by stricture etiology including IUS, acute trauma, iatrogenic, hypospadias, balanitis xerotica obliterans, and radiation...
July 26, 2017: Urology
https://www.readbyqxmd.com/read/28739721/a-preclinical-study-of-cell-seeded-tubularized-scaffolds-specially-secreting-ll37-for-reconstruction-of-long-urethral-defects
#17
Yongwei Li, Jitao Wu, Fan Feng, Changping Men, Diandong Yang, Zhenli Gao, Zhe Zhu, Yuanshan Cui, Hongwei Zhao
AIM: We constructed a new artificial, long tubular acellular matrix, seeded with autologous progenitor cells transfected with the sequence to produce the antibiotic peptide LL37 and another two common seeding cells, which might be adopted for patients requiring repair of long segment of the urethra. MATERIALS AND METHODS: Autologous endothelial progenitor cells transfected by lentiviral vectors expressing antibiotic peptide LL37, as well as urothelial and smooth muscle cells from New Zealand white male rabbits, were cultured and seeded onto preconfigured acellular collagen-based tubular matrices (3 cm in length)...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28738730/male-urethral-reconstruction-using-vagina-as-a-substitute-in-a-45x-46xy-case
#18
Seppo Taskinen, Riikka Järvinen, Maija Kolehmainen, Jukka Sairanen
No abstract text is available yet for this article.
July 25, 2017: Scandinavian Journal of Urology
https://www.readbyqxmd.com/read/28735714/internal-urethrotomy-with-intralesional-mitomycin-c-an-effective-option-for-endoscopic-management-of-recurrent-bulbar-and-bulbomembranous-urethral-strictures
#19
M Ryan Farrell, Cedric Lawrenz, Laurence A Levine
OBJECTIVE: To describe our experience with direct visual internal urethrotomy (DVIU) and mitomycin C (MMC) for recurrent bulbar/bulbomembranous urethral strictures of radiation and non-radiation induced etiologies. METHODS: We reviewed our database of consecutive patients presenting to our tertiary care institution with recurrent bulbar/bulbomembranous urethral strictures who underwent DVIU with MMC from 2011-2016. Patients were stratified by radiation-induced strictures (RIS) versus non-RIS...
July 20, 2017: Urology
https://www.readbyqxmd.com/read/28723371/complications-of-transvaginal-mesh-for-pelvic-organ-prolapse-and-stress-urinary-incontinence-tips-for-prevention-recognition-and-management
#20
REVIEW
Susan MacDonald, Ryan Terlecki, Elisabetta Costantini, Gopal Badlani
CONTEXT: Mesh-related complications following transvaginal management of pelvic organ prolapse (POP) and/or stress urinary incontinence (SUI) have received significant attention in the last decade. OBJECTIVE: We sought to identify patient, product, and technical factors associated with an increased risk of complications after mesh-based transvaginal repair of anterior POP and SUI. In this review we clarify the different pattern of complications after POP and SUI repairs...
August 2016: European Urology Focus
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