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Bronchiolitis obliterans in children

Whitney B Eldridge, Qunyuan Zhang, Albert Faro, Stuart C Sweet, Pirooz Eghtesady, Aaron Hamvas, F Sessions Cole, Jennifer A Wambach
OBJECTIVE: To compare outcomes of infants and children who underwent lung transplantation for genetic disorders of surfactant metabolism (SFTPB, SFTPC, ABCA3, and NKX2-1) over 2 epochs (1993-2003 and 2004-2015) at St Louis Children's Hospital. STUDY DESIGN: We retrospectively reviewed clinical characteristics, mortality, and short- and long-term morbidities of infants (transplanted at <1 year; n = 28) and children (transplanted >1 year; n = 16) and compared outcomes by age at transplantation (infants vs children) and by epoch of transplantation...
February 16, 2017: Journal of Pediatrics
Osman Yeşilbaş, Esra Şevketoğlu, Hasan Serdar Kıhtır, Mey Talip Petmezci, Elif Bato, Seda Balkaya, Nevin Hatipoğlu, Mert Ahmet Kuşkucu, Figen Palabıyık, Erkan Çakır
Human metapneumovirus (hMPV), formerly classified in Paramyxoviridae family is now moved into Pneumoviridae, which was described as a novel family. It causes upper and lower respiratory tract infections (LRTIs) usually in children younger than five years old. The recent epidemiological studies indicated that hMPV is the second most frequently detected virus in LRTIs of young children, following the respiratory syncytial virus (RSV). Bronchiolitis obliterans (BO) is a chronic obstructive lung disease characterized by fibrosis of the distal respiratory airways...
October 2016: Mikrobiyoloji Bülteni
Semiha Bahçeci, Sait Karaman, Hikmet Tekin Nacaroğlu, Selçuk Yazıcı, Saniye Girit, Şule Ünsal-Karkıner, Demet Can
Non-cystic fibrosis bronchiectasis again becomes a major health problem due to inappropriate antibiotic use and increasing frequency of protracted bacterial bronchitis. The aim was to determine the changes in etiology of bronchiectasis. Patients who admitted to Behçet Uz Children Hospital between 2005 and 2015 (n=110) were retrospectively examined. The etiology of bronchiectasis was detected as; primary ciliary dyskinesia 26.4%, protracted bacterial bronchitis 22.8%, primary immune deficiency 11.8%, bronchiolitis obliterans 8...
2016: Turkish Journal of Pediatrics
Eun Lee, Jisun Yoon, Hyun-Ju Cho, Soo-Jong Hong, Jinho Yu
AIM: We investigated airway function in preschoolers with postinfectious bronchiolitis obliterans (PIBO) using impulse oscillometry (IOS). METHODS: This study enrolled 182 children aged three to five years: 12 with PIBO, 135 with asthma and 35 nonatopic controls. Respiratory resistance and reactance were assessed using IOS. RESULTS: The percentage predicted (% predicted) of prebronchodilator respiratory resistance at 5 Hz was significantly higher in children with PIBO (177...
January 2017: Acta Paediatrica
Pei-Qiong Wu, Xing Li, Wen-Hui Jiang, Gen-Quan Yin, Ai-Hua Lei, Qiang Xiao, Jian-Jun Huang, Zhi-Wei Xie, Li Deng
Bronchiolitis obliterans (BO) is an uncommon and severe sequela of chronic obstructive lung disease in children that results from an insult to the lower respiratory tract. Few prognostic factors achieved worldwide acknowledgment. In the present study, we retrospectively collected the children with respiratory adenoviral infection and identified the predictive factors of BO. In the period between Jan 2011 and December 2014, the consecutive in-hospital acute respiratory infection children with positive result for adenovirus were enrolled into the present study...
2016: SpringerPlus
Jonas Eckrich, Eva Herrmann, Sandra Voss, Ralf Schubert, Stefan Zielen, Martin Rosewich
PURPOSE: Bronchiolitis obliterans (BO) is an inadequately researched disease in terms of lung function as well as inflammatory profile. The short-term variation of these parameters has not been investigated. Therefore, the objective of this study was the investigation of lung function, sputum cells and cytokine profiles in BO at two visits within of four to six weeks. METHODS: Twenty patients with BO (median age = 14.6, range 8.3-24.3) performed lung function tests, airway reversibility testing and induction of sputum within four to six weeks...
August 2016: Lung
Dehui Chen, Na Xie, Yuneng Lin, Zifeng Yang, Wenkuan Liu, Shangzhi Wu, Jingbin Chen, Xiaoan Pan, Shaolin Yang, Yong Cai
BACKGROUND: Diagnosis of childhood bronchiolitis obliterans (BO) is difficult owing to non-specific clinical presentations and limited investigational options. There is a lack in established serum biomarkers for BO. While the diagnostic value of antineutrophil cytoplasmic antibodies (ANCAs) has been discussed, little is known about this in BO. We aimed to investigate the serological profiles of ANCAs against myeloperoxidase (MPO-ANCA) and proteinase-3 (PR3-ANCA) in BO and acute pneumonia...
June 2016: Journal of Thoracic Disease
Don Hayes, Dmitry Tumin, Benjamin T Kopp, Joseph D Tobias, Shahid I Sheikh, Stephen E Kirkby
BACKGROUND: The influence of graft ischemic time on survival after lung transplantation (LTx) in children with cystic fibrosis (CF) is not well studied. METHODS: The United Network for Organ Sharing (UNOS) database was queried from May 2005 to September 2013 to examine the impact of ischemic time of <4, 4-6, and >6 hr in pediatric LTx recipients with CF. RESULTS: One hundred and ninety-nine patients with CF under 18 years of age that were first-time LTx recipients from cadaveric donors were included in the analysis...
September 2016: Pediatric Pulmonology
Adam Gassas, Joerg Krueger, Irina Zaidman, Tal Schechter, Hayley Craig-Barnes, Muhammad Ali, Nades Palaniyar
It is plausible that infections post-hematopoietic SCT play a role in the pathogenesis of BOS. A prospective study for children with history, questionnaire, examination, PFTs, and blood counts at one, three, six, nine, 12, 18, and 24 months post-SCT was conducted. Between September 2009 and September 2011 (n = 39), six developed BOS at 200 days (range 94-282), three patients had probable clinical respiratory infection, and all six had higher neutrophil count compared to non-BOS patients (4.7 vs. 2.4 at three months and 6...
March 2016: Pediatric Transplantation
Jinho Yu
Postinfectious bronchiolitis obliterans (PIBO) is an irreversible obstructive lung disease characterized by subepithelial inflammation and fibrotic narrowing of the bronchioles after lower respiratory tract infection during childhood, especially early childhood. Although diagnosis of PIBO should be confirmed by histopathology, it is generally based on history and clinical findings. Irreversible airway obstruction is demonstrated by decreased forced expiratory volume in 1 second with an absent bronchodilator response, and by mosaic perfusion, air trapping, and/or bronchiectasis on computed tomography images...
December 2015: Korean Journal of Pediatrics
Gabriel de Deus Vieira, Alessandra Yukari Yamagishi, Natália Nogueira Vieira, Rebeka Mayara Miranda Dias Fogaça, Thaianne da Cunha Alves, Gisele Megale Brandão Gurgel Amaral, Camila Maciel de Sousa
Swyer-James syndrome is a complication of post-infectious bronchiolitis obliterans that causes inflammation and fibrosis of the bronchial walls. There are two types: asymptomatic, with most cases diagnosed in adults during routine radiological examinations; and symptomatic, most commonly found in children. Here, we report the case of a 6-year-old child with recurrent dyspnea since the age of 3, who showed signs and symptoms of bronchiolitis obliterans and radiological signs of bronchial wall thickening and air trapping...
September 2015: Revista da Associação Médica Brasileira
Francisco A Guzman-Pruneda, Yishay Orr, Jeffrey G Trost, Wei Zhang, Shailendra Das, Ernestina Melicoff, Jennifer Maddox, Melissa Nugent, Carlos M Mery, Iki Adachi, Marc G Schecter, George B Mallory, David L Morales, Jeffrey S Heinle, Emmett D McKenzie
BACKGROUND: Long-term success in pediatric lung transplantation is limited by infection and bronchiolitis obliterans syndrome (BOS). The bilateral sequential lung transplantation (BSLT) technique may result in airway ischemia leading to bronchial stenosis, dehiscence, or loss of small airways. En bloc lung transplant (EBLT) with bronchial artery revascularization (BAR) minimizes airway ischemia, thus promoting superior airway healing. BAR also allows for safe tracheal anastomosis, circumventing the need for bilateral bronchial anastomoses in small children...
January 2016: Journal of Heart and Lung Transplantation
Luiz Vicente Ribeiro Ferreira da Silva Filho, Leonardo Araujo Pinto, Renato Tetelbom Stein
OBJECTIVE: To review the mechanisms of action of macrolides in pediatric respiratory diseases and their clinical indications. SOURCES: Review in the PubMed database, comprising the following terms in English: "macrolide and asthma"; "macrolide and cystic fibrosis"; "macrolide bronchiolitis and viral acute"; "macrolide and bronchiolitis obliterans" and "macrolide and non-CF bronchiectasis". SUMMARY OF THE FINDINGS: The spectrum of action of macrolides includes production of inflammatory mediators, control of mucus hypersecretion, and modulation of host-defense mechanisms...
November 2015: Jornal de Pediatria
Jong-Seo Yoon, Yoon Hong Chun, Jae Wook Lee, Nack Gyun Chung, Bin Cho
Bronchiolitis obliterans syndrome (BOS) is a chronic graft-versus-host disease that occurs in the lungs after hematopoietic stem cell transplantation (HSCT). Serial screening pulmonary function test (PFT) is recommended after transplantation for early diagnosis of BOS. However, little is known about the value or the optimum methods of serial PFT in this context. One hundred and 10 consecutive patients of 6 to 17 years of age at the time of transplantation who underwent allogeneic HSCT were recruited for this study...
November 2015: Journal of Pediatric Hematology/oncology
Manuela Fernández-García, Marta Gonzalez-Vicent, Ignacio Mastro-Martinez, Ana Serrano, Miguel A Diaz
We retrospectively analyzed posttransplantation events in 299 children who underwent hematopoietic stem cell transplantation between 2005 and 2011 in order to ascertain the incidence of life-threatening complications requiring pediatric intensive care unit (PICU) admission, the contributing risk factors, and the patient's long-term survival. Sixty-eight patients (23%) were admitted to the PICU. Risks factors associated with higher cumulative incidence of PICU admission on univariate analysis were nonmalignant disease, status at transplantation, type of transplant, source of stem cell, engraftment syndrome (ES), veno-occlusive disease, acute graft versus host disease (GvHD), chronic GvHD, thrombotic microangiopathy, bronchiolitis obliterans, hemorrhagic cystitis, and posterior reversible encephalopathy syndrome (PRES)...
October 2015: Journal of Pediatric Hematology/oncology
Xueyan Wang, Changshan Liu, Mengjuan Wang, Y I Zhang, Hewen Li, Geli Liu
The aim of the present study was to outline any predisposing factors and clinical and radiological features of post-infectious bronchiolitis obliterans (PIBO) in pediatric patients, and to determine the effect of long-term azithromycin treatment on these factors. In total, 16 cases of children with PIBO were retrospectively reviewed. Adenovirus and Mycoplasma pneumoniae were the most common etiological agents (12/16) in the children with PIBO. The patients presented with persistent dyspnea, a chronic cough, sputum production and wheezing following the initial lung infection...
June 2015: Experimental and Therapeutic Medicine
Zeynep S Uyan, Ihsan Turan, Pinar Ay, Erkan Cakir, Ersin Ozturk, Ahmet H Gedik, Yasemin Gokdemir, Ela Erdem, Velat Şen, Bulent Karadag, Fazilet Karakoc, Refika Ersu
The incidence of sleep-disordered breathing (SDB) increases in chronic lung diseases. Our aim was to evaluate SDB and sleep quality in children with postinfectious bronchiolitis obliterans (BO) and assess associated risk factors. We hypothesized that children with BO are at increased risk for SDB and have impaired sleep quality. We also hypothesized that severity of SDB and impairment of sleep quality is related to the severity of lung disease. Sleep Related Breathing Disorder (SRBD) subscale of the Pediatric Sleep Questionnaire (PSQ) and Pittsburgh Sleep Quality Index (PSQI) questionnaires; spirometry, impulse oscillometry (IOS), and overnight polysomnography (PSG) were performed...
March 2016: Pediatric Pulmonology
Ahmet Hakan Gedik, Erkan Cakir, Yasemin Gokdemir, Zeynep Seda Uyan, Abdurrahim Kocyigit, Emel Torun, Bulent Karadag, Refika Ersu, Fazilet Karakoc
INTRODUCTION: The antimicrobial peptides (AMPs) human β-defensins and cathelicidin (LL-37) are key factors in innate and adaptive immune responses of the respiratory tract and play an important role in many respiratory diseases. No data are available in the literature about the levels of these AMPs in paediatric patients with post-infectious bronchiolitis obliterans (BO). This study aimed to determine human β-defensin 2 (hBD2) and LL-37 levels and compare between post-infectious BO patients and the control group...
June 15, 2015: Clinical Respiratory Journal
Khuen Foong Ng, Kah Kee Tan, Boon Hong Ng, Pritiss Nair, Wan Ying Gan
BACKGROUND: There is scarcity of data regarding epidemiology and clinical aspects of human adenovirus acute respiratory infection (ARI) among children in developing countries. METHODS: Retrospective data on demographics, clinical presentation, outcomes and laboratory findings of 116 children admitted into Tuanku Jaafar Hospital in Seremban, Malaysia from 2012 to 2013 with documented diagnosis of community-acquired adenovirus ARI were collected and analyzed. RESULTS: Male to female ratio was 1...
July 2015: Transactions of the Royal Society of Tropical Medicine and Hygiene
Jin-Rong Liu, Xue-Feng Xu, Chun-Ju Zhou, Hai-Ming Yang, Shun-Ying Zhao
The most common causes of bronchiolitis obliterans organizing pneumonia (BOOP) are connective tissue diseases, organ transplantation, drug reaction, and infections. Although rare, BOOP due to gastroesophageal reflux (GER) has been reported in adults but not to date in pediatric patients. This study describes 2 pediatric patients who developed GER and BOOP. One patient had superior mesenteric artery syndrome and Helicobacter pylori infection, and the other had a gastroduodenal ulcer with reflux esophagitis. Respiratory symptoms occurred concurrently or after gastrointestinal symptoms...
June 2015: Pediatrics
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