keyword
https://read.qxmd.com/read/37941855/prevalence-and-clinical-implications-of-scleroderma-specific-autoantibodies-in-seronegative-patients-with-sicca-complaints
#21
JOURNAL ARTICLE
Nikolaos Marketos, Clio P Mavragani
INTRODUCTION: Previous studies have revealed the presence of anticentromere antibodies in patients with Sjögren's syndrome (SS), predominantly in those serologically negative for antibodies against Ro/SSA and La/SSB antigens (seronegative). The prevalence and clinical significance of specific autoantibodies for Systemic Sclerosis (SSc) in seronegative patients with sicca complaints (dry eyes, dry mouth) have not yet been studied. AIM OF THE STUDY: Investigate the prevalence and clinical significance of SSc-specific autoantibodies in seronegative patients with sicca complaints...
September 2023: Mediterranean journal of rheumatology
https://read.qxmd.com/read/37936644/a-modified-selex-approach-to-identify-dna-aptamers-with-binding-specificity-to-the-major-histocompatibility-complex-presenting-ovalbumin-model-antigen
#22
JOURNAL ARTICLE
Yang Lin, Cho-Yi Chen, Yu-Chia Ku, Li-Chin Wang, Chia-Chien Hung, Zhi-Qian Lin, Bing-Hong Chen, Jui-Tse Hung, Yi-Chen Sun, Kai-Feng Hung
Aptamers have sparked significant interest in cell recognition because of their superior binding specificity and biocompatibility. Cell recognition can be mediated by targeting the major histocompatibility complex (MHC) that presents short peptides derived from intracellular antigens. Although numerous antibodies have demonstrated a specific affinity for the peptide-MHC complex, the number of aptamers that exhibit comparable characteristics is limited. Aptamers are usually selected from large libraries via the Systemic Evolution of Ligands by Exponential Enrichment (SELEX), an iterative process of selection and PCR amplification to enrich a pool of aptamers with high affinity...
October 31, 2023: RSC Advances
https://read.qxmd.com/read/37904342/death-from-mantle-cell-lymphoma-limits-sequential-therapy-particularly-after-first-relapse-patterns-of-care-and-outcomes-in-a-series-from-australia-and-the-united-kingdom
#23
JOURNAL ARTICLE
Adrian Minson, Nada Hamad, Pietro Di Ciaccio, Dipti Talaulikar, Matthew Ku, Sumita Ratnasingam, Chan Cheah, Costas K Yannakou, Mark Bishton, Zi Yun Ng, Shivam Agrawal, Andrew McQuillan, Anna Johnston, Emily Choong, Kimberly Wong, James McQuillan, Ashley Beekman, Eliza Hawkes, Michael Dickinson
Mantle cell lymphoma (MCL) is a B-cell non-Hodgkin lymphoma characterised by a heterogeneous clinical course. Patients can often receive sequential treatments, yet these typically yield diminishing periods of disease control, raising questions about optimal therapy sequencing. Novel agents, such as chimeric antigen receptor T-cell therapies and bispecific antibodies, show promise in relapsed MCL, but are often reserved for later treatment lines, which may underserve patients with aggressive disease phenotypes who die early in the treatment journey...
October 30, 2023: British Journal of Haematology
https://read.qxmd.com/read/37901762/unique-allergen-specific-human-ige-monoclonal-antibodies-derived-from-patients-with-allergic-disease
#24
JOURNAL ARTICLE
Bryan R E Smith, Kristina Reid Black, Max Bermingham, Sayeh Agah, Jill Glesner, Serge A Versteeg, Ronald van Ree, Glorismer Pena-Amelunxen, Lorenz Aglas, Scott A Smith, Anna Pomés, Martin D Chapman
INTRODUCTION: Allergic reactions are mediated by human IgE antibodies that bind to and cross-link allergen molecules. The sites on allergens that are recognized by IgE antibodies have been difficult to investigate because of the paucity of IgE antibodies in a human serum. Here, we report the production of unique human IgE monoclonal antibodies to major inhaled allergens and food allergens that can be produced at scale in perpetuity. MATERIALS AND METHODS: The IgE antibodies were derived from peripheral blood mononuclear cells of symptomatic allergic patients, mostly children aged 3-18 years, using hybridoma fusion technology...
2023: Front Allergy
https://read.qxmd.com/read/37845706/prevalence-clinical-significance-and-persistence-of-autoantibodies-in-covid-19
#25
JOURNAL ARTICLE
Se Ju Lee, Taejun Yoon, Jang Woo Ha, Jinnam Kim, Ki Hyun Lee, Jung Ah Lee, Chang Hyup Kim, Sang-Won Lee, Jung Ho Kim, Jin Young Ahn, Nam Su Ku, Jun Yong Choi, Joon-Sup Yeom, Su Jin Jeong
BACKGROUND: Interest in complications and sequelae following Coronavirus disease 2019 (COVID-19) is increasing. Several articles have reported COVID-19-associated autoimmune diseases and the association between autoantibodies and the severity of COVID-19. Thromboembolic complications are frequent in patients with COVID-19, and the anti-phospholipid antibodies (aPL) is frequently detected. We conducted this study to investigate the prevalence, clinical significance, and persistence of anti-nuclear antibodies (ANA) and aPLs in COVID-19...
October 16, 2023: Virology Journal
https://read.qxmd.com/read/37835823/detection-of-myositis-autoantibodies-by-multi-analytic-immunoassays-in-a-large-multicenter-cohort-of-patients-with-definite-idiopathic-inflammatory-myopathies
#26
JOURNAL ARTICLE
Anna Ghirardello, Mariele Gatto, Chiara Franco, Elisabetta Zanatta, Roberto Padoan, Luana Ienna, Nicoletta Gallo, Margherita Zen, Ingrid E Lundberg, Michael Mahler, Andrea Doria, Luca Iaccarino
BACKGROUND: The usefulness of myositis-specific autoantibodies (MSAs) and myositis-associated autoantibodies (MAAs) for the assessment of idiopathic inflammatory myopathies (IIMs) is acknowledged, but laboratory standardization remains a challenge. We detected MSAs/MAAs by multi-analytic line immunoassay (LIA) and particle-based multi-analyte technology (PMAT) in a multicenter cohort of patients with IIMs. METHODS: We tested the sera from 411 patients affected with definite IIM, including 142 polymyositis (PM), 147 dermatomyositis (DM), 19 cancer-associated myositis, and 103 overlap myositis syndrome (OM), and from 269 controls...
September 28, 2023: Diagnostics
https://read.qxmd.com/read/37760391/epidemiological-and-molecular-approaches-for-a-fatal-feline-panleukopenia-virus-infection-of-captive-siberian-tigers-panthera-tigris-altaica-in-the-republic-of-korea
#27
JOURNAL ARTICLE
Yong-Gu Yeo, Hye-Ryung Kim, Jonghyun Park, Jong-Min Kim, Yeun-Kyung Shin, Kyoung-Ki Lee, Oh-Kyu Kwon, Hye-Young Jeoung, Hae-Eun Kang, Bok-Kyung Ku, Seung-Chun Park, Oh-Deog Kwon, Choi-Kyu Park
Feline panleukopenia virus (FPV), a member of the species Protoparvovirus carnivoran1 , is one of the most fatal pathogens of domestic and wild carnivores. The virus endemically infects domestic carnivores worldwide and its cross-species transmission threatens endangered wild carnivores, including Siberian tigers. In this study, a fatal FPV infection in endangered Siberian tigers was investigated to trace the origin of the virus and elucidate the reason behind FPV's infection of the vaccinated tigers. Our genetic characterization and phylogenetic analysis revealed that the virus detected in the infected tigers, designated as the KTPV-2305 strain, was closely related to FPV strains circulating in Korean cats, suggesting that it might have been transmitted from stray cats wandering around the zoo...
September 21, 2023: Animals: An Open Access Journal From MDPI
https://read.qxmd.com/read/37725435/tumor-derived-biomarkers-predict-efficacy-of-b7h3-antibody-drug-conjugate-treatment-in-metastatic-prostate-cancer-models
#28
JOURNAL ARTICLE
Supreet Agarwal, Lei Fang, Kerry McGowen, JuanJuan Yin, Joel Bowman, Anson T Ku, Aian Neil Alilin, Eva Corey, Martine P Roudier, Lawrence D True, Ruth F Dumpit, Ilsa Coleman, John K Lee, Peter S Nelson, Brian J Capaldo, Aida Mariani, Clare E Hoover, Ilya S Senatorov, Michael Beshiri, Adam G Sowalsky, Elaine M Hurt, Kathleen Kelly
Antibody-drug conjugates(ADCs) are promising targeted cancer therapy; however, patient selection based solely on target antigen expression without consideration for cytotoxic payload vulnerabilities has plateaued clinical benefits. Biomarkers to capture patients who might benefit from specific ADCs have not been systematically determined for any cancer. We present a comprehensive therapeutic and biomarker analysis of a B7H3-ADC with pyrrolobenzodiazepine(PBD) payload in 26 treatment-resistant, metastatic prostate cancer(mPC) models...
September 19, 2023: Journal of Clinical Investigation
https://read.qxmd.com/read/37705677/high-risk-groups-for-alpha-gal-sensitization
#29
JOURNAL ARTICLE
Marie Benders-Guedj, Martin Köberle, Heidelore Hofmann, Tilo Biedermann, Ulf Darsow
BACKGROUND: Tick bite-induced IgE-mediated reactions to the oligosaccharide galactose α-1,3-galactose (alpha-gal) are increasingly recognized. This study investigated alpha-gal sensitization in three groups with different tick bite exposure. MATERIALS AND METHODS: Specific IgE antibodies to alpha-gal and total IgE were investigated in 485 patients with Lyme borreliosis with different disease manifestations and compared to a control group of 200 randomly selected patients without increased exposure to tick bites...
2023: Allergologie Select
https://read.qxmd.com/read/37643795/star-0215-is-a-novel-long-acting-monoclonal-antibody-inhibitor-of-plasma-kallikrein-for-the-potential-treatment-of-hereditary-angioedema
#30
JOURNAL ARTICLE
Vahe Bedian, Nikolaos Biris, Charles Omer, Jou-Ku Chung, James Fuller, Rafif Dagher, Sachin Chandran, Peter Harwin, Tomas Kiselak, Jonathan Violin, Andrew Nichols, Pradeep Bista
Hereditary angioedema (HAE) is a rare autosomal dominant disorder caused by a deficiency in functional C1 esterase inhibitor, a serpin family protein that blocks the activity of plasma kallikrein. Insufficient inhibition of plasma kallikrein results in the overproduction of bradykinin, a vasoactive inflammatory mediator that produces both pain and unpredictable swelling during HAE attacks, with potentially life-threatening consequences. We describe the generation of STAR-0215, a humanized IgG1 antibody with a long circulating half-life (t1/2 ) that potently inhibits plasma kallikrein activity, with a >1000-fold lower affinity for prekallikrein and no measurable inhibitory activity against other serine proteases...
November 2023: Journal of Pharmacology and Experimental Therapeutics
https://read.qxmd.com/read/37624749/cre-loxp-system-based-mouse-model-for-investigating-graves-disease-and-associated-orbitopathy
#31
JOURNAL ARTICLE
Yaru Bao, Daham Kim, Yoon Hee Cho, Cheol Ryong Ku, Jin Sook Yoon, Eun Jig Lee
BACKGROUND: Graves' disease (GD), one of the most common forms of autoimmune thyroid disorder, is characterized by hyperthyroidism caused by antibodies (Ab) against the extracellular A-subunit of the thyrotropin receptor (TSHR). Various approaches have been used to create mouse models of GD, including transfected fibroblasts and immunization with plasmids or adenoviruses expressing human TSHR A-subunit (hTSHR A-subunit). These models, however, require repeated immunizations and produce inconsistent results...
August 25, 2023: Thyroid: Official Journal of the American Thyroid Association
https://read.qxmd.com/read/37558053/liposomal-co-delivery-of-toll-like-receptors-3-and-7-agonists-induce-a-hot-triple-negative-breast-cancer-immune-environment
#32
JOURNAL ARTICLE
Bao Loc Nguyen, Cao Dai Phung, Duc-Vinh Pham, Ngoc Duy Le, Jee-Heon Jeong, Jeonghwan Kim, Ju-Hyun Kim, Jae-Hoon Chang, Sung Giu Jin, Han-Gon Choi, Sae Kwang Ku, Jong Oh Kim
Triple-negative breast cancer (TNBC) is highly aggressive and has no standard treatment. Although being considered as an alternative to conventional treatments for TNBC, immunotherapy has to deal with many challenges that hinder its efficacy, particularly the poor immunogenic condition of the tumor microenvironment (TME). Herein, we designed a liposomal nanoparticle (LN) platform that delivers simultaneously toll-like receptor 7 (imiquimod, IQ) and toll-like receptor 3 (poly(I:C), IC) agonists to take advantage of the different toll-like receptor (TLR) signaling pathways, which enhances the condition of TME from a "cold" to a "hot" immunogenic state...
August 7, 2023: Journal of Controlled Release
https://read.qxmd.com/read/37550859/management-of-subclinical-hypothyroidism-a-focus-on-proven-health-effects-in-the-2023-korean-thyroid-association-guidelines
#33
JOURNAL ARTICLE
Eu Jeong Ku, Won Sang Yoo, Hyun Kyung Chung
Subclinical hypothyroidism (SCH) is characterized by elevated thyroid-stimulating hormone (TSH) and normal free thyroxine levels. The Korean Thyroid Association recently issued a guideline for managing SCH, which emphasizes Korean-specific TSH diagnostic criteria and highlights the health benefits of levothyroxine (LT4) treatment. A serum TSH level of 6.8 mIU/L is presented as the reference value for diagnosing SCH. SCH can be classified as mild (TSH 6.8 to 10.0 mIU/L) or severe (TSH >10.0 mIU/L), and patients can be categorized as adults (age <70 years) or elderly (age ≥70 years), depending on the health effects of LT4 treatment...
August 2023: Endocrinology and Metabolism
https://read.qxmd.com/read/37487907/dnaja3-regulates-b-cell-development-and-immune-function
#34
JOURNAL ARTICLE
Stephanie L Sayson, Jia-Ning Fan, Chien-Liang Ku, Jeng-Fan Lo, Shiu-Huey Chou
BACKGROUND: DnaJ homolog subfamily A member 3 (DNAJA3), also known as the tumorous imaginal disc (Tid1), is shown to be crucial in T cell development. DNAJA3 functions as a tumor suppressor implicated in lymphocyte development and survival. However, the role of DNAJA3 in B cell development and immune function remains unknown. In this study, we utilized a mouse model of B cell-specific DNAJA3 knockout (CD19-Cre/+ ; DNAJA3flx/flx ) to investigate the physiological function of DNAJA3 in B cell development and immune function...
July 22, 2023: Biomedical Journal
https://read.qxmd.com/read/37453844/prevalence-of-anti-synthetase-antibodies-among-systemic-sclerosis-patients
#35
JOURNAL ARTICLE
Wakar Garra, Yair Levy
BACKGROUND: we aimed to estimate the prevalence of Amino acyl-transfer ribonucleic acid synthetase antibodies (Anti-ARS); myositis specific antibodies, among patients with systemic sclerosis (SSc), to evaluate the clinical associations of anti-ARS antibodies in SSc patients and to identify risk factors for development of interstitial lung disease (ILD) in SSc. METHODS: A prospective study of 71 systemic sclerosis patients in our rheumatology clinic in Israel. Sera were tested for myositis antibodies...
November 2023: European Journal of Internal Medicine
https://read.qxmd.com/read/37445823/the-sizes-and-composition-of-hdl-cholesterol-are-significantly-associated-with-inflammation-in-rheumatoid-arthritis-patients
#36
JOURNAL ARTICLE
Ching-Kun Chang, En-Pei Isabel Chiang, Kuang-Hsi Chang, Kuo-Tung Tang, Po-Ku Chen, Hei-Tung Yip, Chu-Huang Chen, Der-Yuan Chen
Rheumatoid arthritis (RA), a chronic inflammatory disease, carries a significant burden of atherosclerotic cardiovascular diseases (ASCVD). With their heterogeneous composition, high-density lipoprotein (HDL) particles have varied athero-protective properties, and some may even increase ASCVD risk. In this prospective and cross-sectional study, we aimed to examine the relationship between HDL sizes/metabolites and inflammation in RA. Using 1 H-NMR-based lipid/metabolomics, differential HDL-related metabolites were identified between RA patients and healthy control (HC) subjects and between RA patients with and without anti-citrullinated peptide antibodies (ACPA)...
June 26, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37436007/clinical-and-autoantibody-profiles-of-systemic-sclerosis-patients-a-cross-sectional-study-from-north-india
#37
JOURNAL ARTICLE
Shounak Ghosh, Dhaval Tanna, Kaustubh Telang, Shahzeene Dhuria, Rajiva Gupta
Objectives This cross-sectional study was designed to assess the clinical profile and frequency of associated autoantibodies in all consecutive patients classified as systemic sclerosis (SSc) at Medanta-the Medicity Hospital, Gurgaon, India. Methods Between August 2017 and July 2019, we identified a total of 119 consecutive patients meeting the American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) 2013 criteria for SSc and 106 patients consented to this study. Their clinical and serological data at the time of enrolment were analysed...
July 1, 2023: Indian Journal of Dermatology, Venereology and Leprology
https://read.qxmd.com/read/37432602/pre-implantation-development-of-cattle-embryos-produced-from-fresh-bull-semen-enriched-for-x-chromosome-bearing-spermatozoa-using-a-monoclonal-antibody
#38
JOURNAL ARTICLE
Sang Jun Uhm, Young Tae Heo, Dong Min Yu, Dong Ku Kim, Mukesh Kumar Gupta
Immunological approaches are gaining attention as a convenient and economical method for sex-sorting mammalian spermatozoa. A monoclonal antibody (WholeMom™) has previously been reported to cause agglutination of Y-chromosome-bearing spermatozoa in frozen-thawed semen for gender preselection. However, its usefulness for gender preselection in fresh semen and subsequent in vitro fertilization (IVF) after freeze-thawing has not been reported. This study investigated the in vitro development of cattle embryos produced from fresh bull semen pre-treated with WholeMom™ monoclonal antibody...
July 11, 2023: Veterinary Research Communications
https://read.qxmd.com/read/37393558/anti-ku-antibody-positive-systemic-sclerosis-and-idiopathic-inflammatory-myopathies-overlap-syndrome-in-children-a-report-of-two-cases-and-a-review-of-the-literature
#39
REVIEW
Saki Kanda, Asami Shimbo, Yoshitaka Nakamura, Ryosuke Matsuno, Shuya Kaneko, Hitoshi Irabu, Kazunari Kaneko, Masaki Shimizu
The occurrence of anti-Ku antibody-positive idiopathic inflammatory myopathy (IIM) in pediatric patients is rare, and therefore, the clinical phenotypes of this disease in such patients remain obscure. We herein report two cases of Japanese female pediatric patients with anti-Ku antibody-positive IIM. One case was unique in that it was complicated by pericardial effusion. Another patient had severe and refractory myositis with immune-mediated necrotizing myopathy. In addition, we reviewed literatures involving a total of 11 pediatric patients with anti-Ku antibody-positive IIM...
July 2, 2023: Clinical Rheumatology
https://read.qxmd.com/read/37329891/trastuzumab-deruxtecan-in-patients-in-the-usa-and-europe-with-her2-positive-advanced-gastric-or-gastroesophageal-junction-cancer-with-disease-progression-on-or-after-a-trastuzumab-containing-regimen-destiny-gastric02-primary-and-updated-analyses-from-a-single
#40
JOURNAL ARTICLE
Eric Van Cutsem, Maria di Bartolomeo, Elizabeth Smyth, Ian Chau, Haeseong Park, Salvatore Siena, Sara Lonardi, Zev A Wainberg, Jaffer Ajani, Joseph Chao, Yelena Janjigian, Amy Qin, Jasmeet Singh, Ferdous Barlaskar, Yoshinori Kawaguchi, Geoffrey Ku
BACKGROUND: Approximately 15-20% of advanced gastric and gastro-oesophageal junction cancers overexpress HER2. In DESTINY-Gastric01, the HER2-targeted antibody-drug conjugate trastuzumab deruxtecan improved response and overall survival versus chemotherapy in patients from Japan and South Korea with locally advanced or metastatic HER2-positive gastric or gastro-oesophageal junction cancer whose disease progressed after two lines of previous therapy including trastuzumab. Here, we report primary and updated analyses of the single-arm, phase 2 DESTINY-Gastric02 trial, which aimed to examine trastuzumab deruxtecan in patients living in the USA and Europe...
July 2023: Lancet Oncology
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