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Ku antibody

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https://www.readbyqxmd.com/read/28176781/rad52-competes-with-ku70-ku86-for-binding-to-s-region-dsb-ends-to-modulate-antibody-class-switch-dna-recombination
#1
Hong Zan, Connie Tat, Zhifang Qiu, Julia R Taylor, Justin A Guerrero, Tian Shen, Paolo Casali
Antibody class-switch DNA recombination (CSR) is initiated by AID-introduced DSBs in the switch (S) regions targeted for recombination, as effected by Ku70/Ku86-mediated NHEJ. Ku-deficient B cells, however, undergo (reduced) CSR through an alternative(A)-NHEJ pathway, which introduces microhomologies in S-S junctions. As microhomology-mediated end-joining requires annealing of single-strand DNA ends, we addressed the contribution of single-strand annealing factors HR Rad52 and translesion DNA polymerase θ to CSR...
February 8, 2017: Nature Communications
https://www.readbyqxmd.com/read/28153851/transverse-myelitis-as-manifestation-of-celiac-disease-in-a-toddler
#2
Hilde Krom, Fleur Sprangers, René van den Berg, Marc Alexander Benninga, Angelika Kindermann
We present a 17-month-old girl with rapidly progressive unwillingness to sit, stand, play, and walk. Furthermore, she lacked appetite, vomited, lost weight, and had an iron deficiency. Physical examination revealed a cachectic, irritable girl with a distended abdomen, dystrophic legs with paraparesis, disturbed sensibility, and areflexia. An MRI scan revealed abnormal high signal intensity on T2-weighted images in the cord on the thoracic level, without cerebral abnormalities, indicating transverse myelitis (TM)...
February 2, 2017: Pediatrics
https://www.readbyqxmd.com/read/28148783/beta-propiolactone-inactivation-of-coxsackievirus-a16-induces-structural-alteration-and-surface-modification-of-viral-capsids
#3
Chen Fan, Xiaohua Ye, Zhiqiang Ku, Liangliang Kong, Qingwei Liu, Cong Xu, Yao Cong, Zhong Huang
: Beta-propiolactone (BPL) is an inactivating agent widely used in the vaccine industry. However, its effects on vaccine protein antigens and its mechanisms of action remain poorly understood. Here we presented cryo-EM structures of BPL-treated coxsackievirus A16 (CVA16) mature virion and procapsid at resolutions of 3.9 Å and 6.5 Å, respectively. Notably, both particles were found to adopt an expanded conformation resembling the 135S-like uncoating intermediate, with characteristic features including an opened 2-fold channel, the externalization of the N-terminus of VP1 capsid protein as well as the absence of pocket factor...
February 1, 2017: Journal of Virology
https://www.readbyqxmd.com/read/27940596/predicting-cardiopulmonary-involvement-in-patients-with-systemic-sclerosis-complementary-value-of-nailfold-videocapillaroscopy-patterns-and-disease-specific-autoantibodies
#4
Iris M Markusse, Jessica Meijs, Berber de Boer, Jaap A Bakker, H Pascal C Schippers, Anne A Schouffoer, Nina Ajmone Marsan, Lucia J M Kroft, Maarten K Ninaber, Tom W J Huizinga, Jeska K de Vries-Bouwstra
OBJECTIVE: To evaluate the prevalence of anti-extractable nuclear antigen (anti-ENA) antibodies in Dutch SSc patients and the predictive power of the combination of specific anti-ENA antibodies and nailfold videocapillaroscopy (NVC) patterns to improve identification of patients with high risk for cardiopulmonary involvement. METHODS: A total of 287 patients (79%) from the Leiden SSc-Cohort had data available on NVC-pattern (no SSc-specific, early, active, late) and anti-ENA antibodies...
December 10, 2016: Rheumatology
https://www.readbyqxmd.com/read/27925296/metal-organic-framework-as-a-protective-coating-for-biodiagnostic-chips
#5
Congzhou Wang, Sirimuvva Tadepalli, Jingyi Luan, Keng-Ku Liu, Jeremiah J Morrissey, Evan D Kharasch, Rajesh R Naik, Srikanth Singamaneni
A zeolitic imidazolate framework-8 (ZIF-8) grown around antibodies anchored to plasmonic nanostructures serve as a protective layer to preserve the biorecognition ability of antibodies stored at room and elevated temperatures for several days. The biofunctionality of the ZIF-8 protected biochip can be restored by a simple water rinsing step, making it highly convenient for use in point-of-care and resource-limited settings.
December 7, 2016: Advanced Materials
https://www.readbyqxmd.com/read/27903863/internalization-of-secreted-antigen-targeted-antibodies-by-the-neonatal-fc-receptor-for-precision-imaging-of-the-androgen-receptor-axis
#6
Daniel L J Thorek, Philip A Watson, Sang-Gyu Lee, Anson T Ku, Stylianos Bournazos, Katharina Braun, Kwanghee Kim, Kjell Sjöström, Michael G Doran, Urpo Lamminmäki, Elmer Santos, Darren Veach, Mesruh Turkekul, Emily Casey, Jason S Lewis, Diane S Abou, Marise R H van Voss, Peter T Scardino, Sven-Erik Strand, Mary L Alpaugh, Howard I Scher, Hans Lilja, Steven M Larson, David Ulmert
Targeting the androgen receptor (AR) pathway prolongs survival in patients with prostate cancer, but resistance rapidly develops. Understanding this resistance is confounded by a lack of noninvasive means to assess AR activity in vivo. We report intracellular accumulation of a secreted antigen-targeted antibody (SATA) that can be used to characterize disease, guide therapy, and monitor response. AR-regulated human kallikrein-related peptidase 2 (free hK2) is a prostate tissue-specific antigen produced in prostate cancer and androgen-stimulated breast cancer cells...
November 30, 2016: Science Translational Medicine
https://www.readbyqxmd.com/read/27865104/detection-of-low-abundance-biomarker-lipocalin-1-for-diabetic-retinopathy-using-optoelectrokinetic-bead-based-immunosensing
#7
Jhih-Cheng Wang, Hu-Yao Ku, Tain-Song Chen, Han-Sheng Chuang
Early diagnosis of diabetic retinopathy (DR) is vital but challenging. DR is a common complication and a major cause of vision loss in patients with diabetes mellitus. Without appropriate medical intervention, visual impairment may become a great burden to our healthcare system. In clinical practice, the current diagnostic methods, such as fluorescence angiography and optical coherence tomography, remain constrained by non-quantitative examinations and individual ophthalmologists' experiences. Late diagnosis often prevents early treatment...
March 15, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/27835848/biochemical-characterization-and-immunolocalization-studies-of-a-capsicum-chinense-jacq-protein-fraction-containing-ding-proteins-and-anti-microbial-activity
#8
Ligia Brito-Argáez, José A Tamayo-Sansores, Dianeli Madera-Piña, Francisco J García-Villalobos, Rosa E Moo-Puc, Ángela Kú-González, Marco A Villanueva, Ignacio Islas-Flores
The DING protein family consists of proteins of great biological importance due to their ability to inhibit carcinogenic cell growth. A DING peptide with Mr ∼7.57 kDa and pI ∼5.06 was detected in G10P1.7.57, a protein fraction from Capsicum chinense Jacq. seeds. Amino acid sequencing of the peptide produced three smaller peptides showing identity to the DING protein family. G10P1.7.57 displayed a phosphatase activity capable of dephosphorylating different phosphorylated substrates and inhibited the growth of Saccharomyces cerevisiae cells...
December 2016: Plant Physiology and Biochemistry: PPB
https://www.readbyqxmd.com/read/27793685/transcutaneous-immunization-via-rapidly-dissolvable-microneedles-protects-against-hand-foot-and-mouth-disease-caused-by-enterovirus-71
#9
Zhuangzhi Zhu, Xiaohua Ye, Zhiqiang Ku, Qingwei Liu, Chaoyun Shen, Huafei Luo, Hansen Luan, Chenghao Zhang, Shaoqiong Tian, CheeYen Lim, Zhong Huang, Hao Wang
Recent large outbreaks of hand-foot-and-mouth disease (HFMD) have seriously affected the health of young children. Enterovirus 71 (EV71) is the main causative agent of HFMD. Herein, for the first time, rapidly dissolvable microneedles (MNs) loaded with EV71 virus-like particles (VLPs) were evaluated whether they could induce robust immune responses that confer protection against EV71 infection. The characteristics of prepared MNs including hygroscopy, mechanical strength, insertion capacity, dissolution profile, skin irritation and storage stability were comprehensively assessed...
December 10, 2016: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/27684828/pulmonary-arterial-hypertension-in-idiopathic-inflammatory-myopathies-data-from-the-french-pulmonary-hypertension-registry-and-review-of-the-literature
#10
REVIEW
Sébastien Sanges, Cécile M Yelnik, Olivier Sitbon, Olivier Benveniste, Kuberaka Mariampillai, Mathilde Phillips-Houlbracq, Christophe Pison, Christophe Deligny, Jocelyn Inamo, Vincent Cottin, Luc Mouthon, David Launay, Marc Lambert, Pierre-Yves Hatron, Laurence Rottat, Marc Humbert, Eric Hachulla
Occurrence of pulmonary arterial hypertension (PAH) in idiopathic inflammatory myopathies (IIMs) without extensive interstitial lung disease (ILD) has rarely been described in the medical literature. This study aimed to report all cases with association of PAH and IIM in the French Pulmonary Hypertension (PH) Registry, to identify IIM features associated with the presence of PAH, and to describe treatment modalities of these patients.All cases of IIM-PAH were retrieved from the French PH Registry, which gathers PH patients prospectively enrolled by 27 referral hospital centers across France...
September 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27632981/interaction-of-interferon-alpha-therapy-with-thyroid-function-tests-in-the-management-of-hepatitis-c-a-case-report
#11
Gurmit Gill, Hammad Bajwa, Peter Strouhal, Harit N Buch
BACKGROUND: Interferon alpha is a widely used therapeutic agent in the treatment of hepatitis C virus infection. Clinical thyroid disease is seen in nearly 15 % of patients receiving interferon alpha for hepatitis C virus infection. The mechanism of thyroid dysfunction with interferon alpha is either autoimmune or inflammatory. We report a case of young woman who developed biphasic thyroid dysfunction posing a diagnostic challenge, while receiving interferon alpha treatment for hepatitis C virus infection...
September 15, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27600137/comparisons-of-serum-infliximab-and-antibodies-to-infliximab-tests-used-in-inflammatory-bowel-disease-clinical-trials-of-remicade%C3%A2
#12
Joseph C Marini, Jocelyn Sendecki, Freddy Cornillie, John W Popp, Shawn Black, Marion Blank, Ann Gils, Thomas Van Stappen, Dörte Hamann, Theo Rispens, Lina Thérien, Kelly Chun, Gopi Shankar
Monitoring infliximab (IFX) concentrations and antibodies-to-IFX (ATI) titers during inflammatory bowel disease treatment may allow more informed decisions in assessing exposure/response and determining appropriate dosing. To aid in interpreting results from different commercial tests in the context of Janssen's published Remicade® results, the reliability of Janssen's IFX and ATI assays was compared with commercial assays from KU Leuven, Sanquin, Dynacare, and LabCorp. Test results were independently reported to Janssen...
January 2017: AAPS Journal
https://www.readbyqxmd.com/read/27583908/single-specificity-anti-ku-antibodies-in-an-international-cohort-of-2140-systemic-sclerosis-subjects-clinical-associations
#13
MULTICENTER STUDY
S Hoa, M Hudson, Y Troyanov, S Proudman, J Walker, W Stevens, M Nikpour, S Assassi, M D Mayes, M Wang, M Baron, M J Fritzler
Autoantibodies directed against the Ku autoantigen are present in systemic sclerosis (SSc) and have been associated with myositis overlap and interstitial lung disease (ILD). However, there is a paucity of data on the clinical correlates of anti-Ku antibodies in the absence of other SSc-specific antibodies. The aim of this study was to assess the clinical correlates of single-specificity anti-Ku in SSc.An international (Canada, Australia, USA, Mexico) cohort of 2140 SSc subjects was formed, demographic and clinical variables were harmonized, and sera were tested for anti-Ku using a line immunoassay...
August 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27568879/tumour-cell-surface-antigen-targeted-therapies-in-b-cell-lymphomas-beyond-rituximab
#14
REVIEW
Matthew Ku, Geoff Chong, Eliza A Hawkes
Recent proliferation of novel targeted therapies in lymphoma has been substantial. B-cell receptor pathway inhibitors and immune checkpoint inhibitors have been a major focus, however significant advances in monoclonal antibodies (MoAbs) which directly target malignant cells have also occurred. These MoAbs continue to make significant impact in lymphoma management. Novel dosing schedules of anti-CD20 MoAb rituximab potentially optimise efficacy in specific lymphoma subgroups, as certain populations may be receiving suboptimal doses using current schedules...
January 2017: Blood Reviews
https://www.readbyqxmd.com/read/27562093/inactivated-coxsackievirus-a10-experimental-vaccines-protect-mice-against-lethal-viral-challenge
#15
Chaoyun Shen, Qingwei Liu, Yu Zhou, Zhiqiang Ku, Lili Wang, Ke Lan, Xiaohua Ye, Zhong Huang
Coxsackievirus A10 (CVA10) has become one of the major causative agents of hand, foot and mouth disease (HFMD). It is now recognized that CVA10 should be targeted for vaccine development. We report here that β-propiolactone inactivated whole-virus based CVA10 vaccines can elicit protective immunity in mice. We prepared two inactivated CVA10 experimental vaccines derived from the prototype strain CVA10/Kowalik and from a clinical isolate CVA10/S0148b, respectively. Immunization with the experimental vaccines elicited CVA10-specific serum antibodies in mice...
September 22, 2016: Vaccine
https://www.readbyqxmd.com/read/27540627/pegylated-artificial-antibodies-plasmonic-biosensors-with-improved-selectivity
#16
Jingyi Luan, Keng-Ku Liu, Sirimuvva Tadepalli, Qisheng Jiang, Jeremiah J Morrissey, Evan D Kharasch, Srikanth Singamaneni
Molecular imprinting, which involves the formation of artificial recognition elements or cavities with complementary shape and chemical functionality to the target species, is a powerful method to overcome a number of limitations associated with natural antibodies. An important but often overlooked consideration in the design of artificial biorecognition elements based on molecular imprinting is the nonspecific binding of interfering species to noncavity regions of the imprinted polymer. Here, we demonstrate a universal method, namely, PEGylation of the noncavity regions of the imprinted polymer, to minimize the nonspecific binding and significantly enhance the selectivity of the molecular imprinted polymer for the target biomolecules...
September 14, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/27538058/advances-in-serological-diagnostics-of-inflammatory-myopathies
#17
Olivier Benveniste, Werner Stenzel, Yves Allenbach
PURPOSE OF REVIEW: Inflammatory myopathies are rare diseases. Their diagnosis criteria are historically based on their clinical phenotype (topography of the muscle weakness, presence of skin lesions and/or of extra-skin/muscle signs) and the presence of inflammatory infiltrates on muscle biopsy. However, the recent discovery of different myositis-specific antibodies (MSA) or myositis-associated antibodies (MAA) permitted to revisit these old classifications. This review covers recent findings in clinical and pathological phenotypes regarding prognosis, associated cancer and response to the treatment based on MSA/MAA categorization...
October 2016: Current Opinion in Neurology
https://www.readbyqxmd.com/read/27525523/identification-of-a-major-epitope-by-anti-interferon-%C3%AE-autoantibodies-in-patients-with-mycobacterial-disease
#18
Chia-Hao Lin, Chih-Yu Chi, Han-Po Shih, Jing-Ya Ding, Chia-Chi Lo, Shang-Yu Wang, Chen-Yen Kuo, Chun-Fu Yeh, Kun-Hua Tu, Shou-Hsuan Liu, Hung-Kai Chen, Chen-Hsuan Ho, Mao-Wang Ho, Chen-Hsiang Lee, Hsin-Chin Lai, Cheng-Lung Ku
The binding of autoantibodies (autoAbs) to interferon (IFN)-γ in people with mycobacterial diseases has become an emerging medical concern. Many patients display specific human leukocyte antigen (HLA) class II haplotypes, which suggests that a common T cell-dependent and B cell-dependent mechanism might underlie the production of specific anti-IFN-γ autoAbs. We show here that these autoAbs target a major epitope (amino acids 121-131, designated position (P)121-131) in a region crucial for IFN-γ receptor (IFN-γR) activation to impair IFN-γ-mediated activities...
September 2016: Nature Medicine
https://www.readbyqxmd.com/read/27505432/real-life-study-for-the-diagnosis-of-house-dust-mite-allergy-the-value-of-recombinant-allergen-based-ige-serology
#19
Sven Becker, Thomas Schlederer, Matthias F Kramer, Mareike Haack, Susanne Vrtala, Yvonne Resch, Christian Lupinek, Rudolf Valenta, Moritz Gröger
BACKGROUND: Dermatophagoides pteronyssinus is one of the most important perennial allergen sources worldwide. Molecular diagnostics using the commercially available major allergens (Der p 1 and Der p 2) in combination with Der p 10 do not detect house dust mite (HDM) sensitization in a number of cases when used alone. The objective was to evaluate the IgE reactivity profiles of these patients using an experimental immunoassay biochip. METHODS: Sera of HDM-allergic patients (positive skin prick test, CAP class ≥1 for allergen extract, and positive intranasal provocation) were tested for IgE antibodies against Der p 1, Der p 2, and Der p 10 by ImmunoCAP fluorescence enzyme immunoassay...
2016: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/27477413/sarcoid-myositis-with-anti-ku-antibody-consistent-with-both-sarcoidosis-and-polymyositis
#20
Nobuyasu Awano, Kensuke Fukuda, Masashi Sakayori, Keisuke Kondoh, Ryu Ono, Atsuko Moriya, Tsunehiro Ando, Toshio Kumasaka, Tamiko Takemura, Soichiro Ikushima
We herein describe a case of sarcoid myositis with anti-Ku antibody positivity. Pathological findings of the muscle were compatible with sarcoidosis, but could not be completely distinguished from myositis diseases that arise from other causes. According to a physical examination, pathological findings, the detection of anti-Ku antibody and the human leukocyte antigen (HLA)-DPB1 allele, we strongly suspected that the patient developed both sarcoidosis and polymyositis. Sarcoidosis is often complicated by autoimmune diseases...
2016: Internal Medicine
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