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Ku antibody

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https://www.readbyqxmd.com/read/29201788/prevalence-of-hepatitis-b-virus-and-hepatitis-c-virus-in-a-tea-garden-of-bangladesh
#1
Mamun Al Mahtab, Shamima Akhter, Kutub U Mollick, Mohammad H Uddin, Sakirul I Khan, Sheikh Mf Akbar
Introduction: The overall health status of workers of tea garden of Bangladesh is below the national standard. Also, almost nothing has been reported about status of hepatitis virus infection among these population and there is also a lack of consensus. Materials and methods: Several health-related facts, especially those of liver diseases, were collected from 130 workers of tea garden via questionnaire. Sera were also collected from these subjects to assess positivity of hepatitis B surface antigen (HBsAg) and antibody to hepatitis C virus (anti-HCV)...
January 2017: Euroasian Journal of Hepato-Gastroenterology
https://www.readbyqxmd.com/read/29151520/dropped-head-syndrome-and-the-presence-of-rimmed-vacuoles-in-a-muscle-biopsy-in-scleroderma-polymyositis-overlap-syndrome-associated-with-anti-ku-antibody
#2
Yoshida Takeshi, Yoshida Mai, Mitsuyo Kinjo, Jonosono Manabu, Higuchi Itsuro
A 66-year-old woman with a history of interstitial lung disease presented with a 3-month history of dropped head syndrome (DHS), followed by camptocormia and extremity weakness. A clinical examination revealed Raynaud phenomenon, arthralgia, distal skin sclerosis, and microbleeds in the nailfold capillaries. An anti-Ku antibody test was positive. A muscle biopsy revealed inflammatory myopathy with rimmed vacuoles (RVs). The diagnosis of scleroderma-polymyositis (SSc-PM) overlap syndrome was made. RVs on a muscle biopsy in a patient with inflammatory myositis involving axial muscles may be seen either in inclusion body myositis or SSc-PM overlap syndrome...
November 20, 2017: Internal Medicine
https://www.readbyqxmd.com/read/29129664/hemistepsin-a-ameliorates-acute-inflammation-in-macrophages-via-inhibition-of-nuclear-factor-%C3%AE%C2%BAb-and-activation-of-nuclear-factor-erythroid-2-related-factor-2
#3
Jae Kwang Kim, Ji Eun Lee, Eun Hye Jung, Ji Yun Jung, Dae Hwa Jung, Sae Kwang Ku, Il Je Cho, Sang Chan Kim
Hemistepsin A (HsA) is a sesquiterpene lactone isolated from Hemistepta lyrata (Bunge) Bunge. We investigated the anti-inflammatory effects of HsA and sought to determine its mechanisms of action in macrophages. HsA pretreatment inhibited nitric oxide production, and reduced the expression of iNOS and COX-2 in Toll-like receptor ligand-stimulated RAW 264.7 cells. Additionally, HsA decreased the secretion of proinflammatory cytokines in lipopolysaccharide (LPS)-stimulated Kupffer cells as well as in RAW 264...
November 9, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/29129093/xxxxx
#4
Tomas G Lyons, Geoffrey Y Ku
The poor prognosis for patients with esophagogastric cancers (EGC) requires the development of newer more effective therapies to further improve the treatment outcomes for this disease. Immunotherapy is a novel treatment strategy that is dramatically changing the treatment landscape for several types of cancers. Cytotoxic T lymphocyte antigen-4 (CTLA-4) and programmed death the programmed death (PD)-1/PD-ligand are essential immune checkpoint inhibitors that suppress T cell activation. Targeting of these immune checkpoints with monoclonal antibodies has shown clinical efficacy in several solid tumors which has led to their approval and use in routine clinical practice...
October 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29129088/systemic-therapy-for-esophagogastric-cancer-targeted-therapies
#5
Tomas G Lyons, Geoffrey Y Ku
The poor prognosis for patients with esophagogastric cancers (EGC) has resulted in an increased focus on the use of targeted agents in this disease. Targets include epidermal growth factor receptor (EGFR), vascular endothelial growth factor (VEGF), Her2, mammalian target of rapamycin (mTOR), MET, poly (ADP-ribose) polymerase (PARP) and claudin 18.2 (CLDN18.2). Trastuzumab, an anti-Her2 antibody, was approved by the U.S. FDA in 2010 as first-line therapy in combination with chemotherapy for Her2-positive disease...
October 2017: Chinese Clinical Oncology
https://www.readbyqxmd.com/read/29122777/genetic-predictors-of-response-to-systemic-therapy-in-esophagogastric-cancer
#6
Yelena Y Janjigian, Francisco Sanchez-Vega, Philip Jonsson, Walid K Chatila, Jaclyn F Hechtman, Geoffrey Y Ku, Jamie C Riches, Yaelle Tuvy, Ritika Kundra, Nancy Bouvier, Efsevia Vakiani, Jianjiong Gao, Zachary J Heins, Benjamin E Gross, David P Kelsen, Liying Zhang, Vivian E Strong, Mark Schattner, Hans Gerdes, Daniel G Coit, Manjit Bains, Zsofia K Stadler, Valerie W Rusch, David R Jones, Daniela Molena, Jinru Shia, Mark E Robson, Marinela Capanu, Sumit Middha, Ahmet Zehir, David M Hyman, Maurizio Scaltriti, Marc Ladanyi, Neal Rosen, David H Ilson, Michael F Berger, Laura Tang, Barry S Taylor, David B Solit, Nikolaus Schultz
The incidence of esophagogastric cancer is rapidly rising but only a minority of patients derive durable benefit from current therapies. Chemotherapy as well as anti-HER2 and PD-1 antibodies are standard treatments. To identify predictive biomarkers of drug sensitivity and mechanisms of resistance, we implemented prospective tumor sequencing of metastatic esophagogastric cancer patients. There was no association between HRD defects and response to platinum-based chemotherapy. Patients with MSI-H tumors were intrinsically resistant to chemotherapy but more likely to achieve durable responses to immunotherapy...
November 9, 2017: Cancer Discovery
https://www.readbyqxmd.com/read/29115398/vibrio-vulnificus-infection-induces-the-maturation-and-activation-of-dendritic-cells-with-inflammatory-th17-polarizing-ability
#7
Arim Lee, Hui Xuan Lim, Myun Soo Kim, Daeho Cho, Kyung Ku Jang, Sang Ho Choi, Tae Sung Kim
Vibrio vulnificus (V. vulnificus) is a gram-negative bacterium, which causes life-threatening septicemia and gastroenteritis through the consumption of contaminated seafood or wound infection. In addition, V. vulnificus infection is known to stimulate the production of several pro-inflammatory cytokines, which are associated with inflammatory responses mediated predominantly by dendritic cells (DCs), functioning as antigen-presenting cells. The present study aimed to investigate whether V. vulnificus infection induced the maturation and activation of murine DCs, which have the ability to polarize T helper (Th) cells into Th17 cells...
November 1, 2017: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/29083477/intranasal-administration-of-allergen-increases-specific-ige-whereas-intranasal-omalizumab-does-not-increase-serum-ige-levels-a-pilot-study
#8
Julia Eckl-Dorna, Renate Fröschl, Christian Lupinek, Renata Kiss, Pia Gattinger, Katharina Marth, Raffaela Campana, Katharina Blatt, Peter Valent, Regina Selb, Andrea Mayer, Katharina Gangl, Irene Steiner, Jutta Gamper, Thomas Perkmann, Petra Zieglmayer, Philippe Gevaert, Rudolf Valenta, Verena Niederberger
BACKGROUND: Administration of the therapeutic anti-IgE antibody omalizumab to patients induces strong increases of IgE antibody levels. OBJECTIVE: To investigate the effect of intranasal administration of major birch pollen allergen Bet v 1, omalizumab or placebo on the levels of total and allergen-specific IgE in patients with birch pollen allergy. METHODS: Based on the fact that intranasal allergen application induces rises of systemic allergen-specific IgE we performed a double-blind placebo-controlled pilot trial in which birch pollen allergic subjects were challenged intranasally with omalizumab, placebo or birch pollen allergen Bet v 1...
October 30, 2017: Allergy
https://www.readbyqxmd.com/read/29070691/structure-immunogenicity-and-protective-mechanism-of-an-engineered-enterovirus-71-like-particle-vaccine-mimicking-80s-empty-capsid
#9
Xiaoli Wang, Zhiqiang Ku, Xiang Zhang, Xiaohua Ye, Jinhuan Chen, Qingwei Liu, Wei Zhang, Chao Zhang, Zhenglin Fu, Xia Jin, Yao Cong, Zhong Huang
Enterovirus 71 (EV71) is the major causative agent of severe hand, foot and mouth disease which affects millions of young children in the Asia-Pacific region annually. In this study, we engineered a novel EV71 virus-like particle (VLP) that lacks VP4 (thereby designated "VLPΔVP4"), and investigated its structure, antigenicity and vaccine potential. The cryo-EM structure of VLPΔVP4 was reconstructed to 3.71 Å resolution. Results from structural and biochemical analyses reveal that VLPΔVP4 resembles the end product of the viral uncoating process, the 80S empty capsid...
October 25, 2017: Journal of Virology
https://www.readbyqxmd.com/read/29029527/targeted-first-line-therapies-for-advanced-colorectal-cancer-a-bayesian-meta-analysis
#10
Yassine Ridouane, Gilberto Lopes, Geoffrey Ku, Hasan Masud, Benjamin Haaland
BACKGROUND: Colorectal cancer is common and deadly. First-line treatments for patients with metastatic disease include FOLFIRI and FOLFOX, which have been combined with anti-EGFR or anti-VEGF antibodies to achieve benefit in selected populations. However, optimal therapy remains unclear. RESULTS: Fifteen publications on 10 trials were identified. There was a lack of decisive evidence that FOLFIRI or FOLFOX impact efficacy of either anti-EGFR or anti-VEGF, across mutational status groups...
September 12, 2017: Oncotarget
https://www.readbyqxmd.com/read/29016136/specific-unbinding-forces-between-mutated-human-p-selectin-glycoprotein-ligand-1-and-viral-protein-1-measured-using-force-spectroscopy
#11
Chen-Chu Wang, Kundan Sivashanmugan, Chung-Ku Chen, Jian-Ren Hong, Wei-I Sung, Jiunn-Der Liao, Yuh-Shyong Yang
Protein tyrosine sulfation (PTS) is a key modulator of extracellular protein-protein interaction (PPI), which regulates principal biological processes. For example, the capsid protein VP1 of enterovirus 71 (EV71) specifically interacts with sulfated P-selectin glycoprotein ligand-1 (PSGL-1) to facilitate virus invasion. Currently available methods cannot be used to directly observe PTS-induced PPI. In this study, atomic force microscopy was used to measure the interaction between sulfated or mutated PSGL-1 and VP1...
October 13, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28990103/silver-nanoparticles-coupled-to-anti%C3%A2-egfr-antibodies-sensitize-nasopharyngeal-carcinoma-cells-to-irradiation
#12
Dahai Yu, Yan Zhang, Hong Lu, Di Zhao
Radiotherapy is the major form of treatment for head and neck carcinoma, a malignant tumour of epithelial origin. The identification of agents, which can be co‑administered in order to sensitize these tumours to radiotherapy, has become a major focus of investigations. In the present study, a novel 20 nm nanocomposite, Ag/C225, was constructed, which consisted of silver nanoparticles (AgNPs) conjugated to an epidermal growth factor receptor‑specific antibody (C225). Physical characterization demonstrated that the Ag/C225 nanoparticles were spherical and dispersed well in water...
December 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28950916/%C3%AE-carboxymuconolactone-decarboxylase-a-novel-cell-cycle-related-basal-body-protein-in-the-early-branching-eukaryote-trichomonas-vaginalis
#13
Wei-Hung Cheng, Kuo-Yang Huang, Po-Jung Huang, Chi-Ching Lee, Yuan-Ming Yeh, Fu-Man Ku, Rose Lin, Mei-Ling Cheng, Cheng-Hsun Chiu, Petrus Tang
BACKGROUND: γ-Carboxymuconolactone decarboxylase (CMD) participates in the β-ketoadipate pathway, which catalyzes aromatic compounds to produce acetyl- or succinyl-CoA, in prokaryotes and yeast. Our previous study demonstrated that expression of a CMD homologue that contains two signatures (dualCMD) is negatively regulated by iron in Trichomonas vaginalis. However, we were not able to identify the components of the β-ketoadipate pathway in the parasite's genome. These observations prompted us to investigate the biological functions of this novel CMD homologue in T...
September 26, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28924447/passive-blood-anaphylaxis-subcutaneous-immunoglobulins-are-a-cause-of-ongoing-passive-anaphylactic-reaction
#14
Przemyslaw Zdziarski, Andrzej Gamian, Jacek Majda, Agnieszka Korzeniowska-Kowal
BACKGROUND: Allergic, especially anaphylactic, reactions during immunoglobulin replacement therapy are rare, but their pathophysiology and classification remain ambiguous. Recent findings show positive results of skin tests with commercially available immunoglobulins, but target antigens and responsible compounds of the tested immunoglobulins have not been strictly identified. CASE DESCRIPTION AND FINDINGS: Four adult patients with recently diagnosed common variable immunodeficiency qualified for standard subcutaneous immunoglobulin replacement therapy regimen...
2017: Allergy, Asthma, and Clinical Immunology
https://www.readbyqxmd.com/read/28699537/recent-advances-in-polymeric-nanosystems-for-treating-cutaneous-melanoma-and-its-metastasis
#15
Yi-Ping Chou, Yin-Ku Lin, Chun-Han Chen, Jia-You Fang
Melanoma shows a high possibility of mortality after it metastasizes because of its aggressive nature. Although there are several options for anti-melanoma therapy, this skin malignancy is resistant to some therapies. Chemotherapy, biochemotherapy, immunotherapy, and adoptive cell therapy have failed to exhibit a significant amelioration in overall survival. Nanomedicine provides an opportunity to improve the efficiency of the anti-melanoma regimen. Nanoparticles for treating melanoma provide the advantages over conventional therapies such as drug solubility increment, drug stability enhancement, epithelium permeability and bioavailability amelioration, half-life prolonging, tumor targeting, and side effect minimization...
July 10, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28544337/growth-curves-of-normal-serum-total-ige-levels-throughout-childhood-a-quantile-analysis-in-a-birth-cohort
#16
Chiara Sacco, Serena Perna, Donatella Vicari, Marco Alfò, Carl-Peter Bauer, Ute Hoffman, Johannes Forster, Fred Zepp, Antje Schuster, Ulrich Wahn, Thomas Keil, Susanne Lau, Paolo Maria Matricardi
BACKGROUND: Previous studies of serum total IgE (t-IgE) were not able to discriminate well-enough atopic from non-atopic subjects, that is, with or without serum-specific IgE antibodies to allergens. OBJECTIVES: To model growth curves of the total IgE levels in children without atopic sensitization (hereafter defined as "normal" t-IgE levels) and to test their usefulness in predicting atopic sensitization. METHODS: The German Multicentre Allergy Study (MAS), a birth cohort with 1314 recruited newborns, began in 1990 and examined the participants until age 20 years...
September 2017: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/28476984/optical-detection-of-ca-15-3-breast-cancer-antigen-using-cds-quantum-dot
#17
Venugopal Elakkiya, Mridula Prakash Menon, Devaraj Nataraj, Pullithadathil Biji, Rajendran Selvakumar
The present study focus on optical sensing of breast cancer antigen 15.3 (CA 15.3) using cadmium sulphide quantum dot (CdS-QD) in saline and serum samples spiked with antigen. The surface of CdS-QD was modified by cysteamine capping followed by tagging of CA 15.3 antibody. The samples were characterised using UV-visible absorption spectroscopy (UV-VIS Spectroscopy), Fourier transform infrared spectroscopy (FTIR), high-resolution transmission electron microscopy (HRTEM) attached with energy-dispersive X-ray spectroscopy, phase contrast inverted epi-fluorescence microscopy and photoluminescence (PL) spectrophotometry (EDS)...
April 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28432705/prognosis-of-infantile-food-protein-induced-enterocolitis-syndrome-in-japan
#18
Mitsuaki Kimura, Masaki Shimomura, Hideaki Morishita, Takaaki Meguro
BACKGROUND: Although serum C-reactive protein (CRP) and the percentage of eosinophils in peripheral blood (Eo) are increased at onset in infants with food protein-induced enterocolitis syndrome (FPIES), the relationship of these laboratory findings to prognosis is presently unknown. METHODS: Correlation of serum CRP and Eo at onset with prognosis was analyzed in 32 patients with FPIES caused by cow's milk (CM). RESULTS: The rate of tolerance acquisition was 18...
April 22, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28422732/molecular-and-serologic-markers-of-hpv-16-infection-are-associated-with-local-recurrence-in-patients-with-oral-cavity-squamous-cell-carcinoma
#19
Chung-Guei Huang, Li-Ang Lee, Chun-Ta Liao, Tzu-Chen Yen, Shu-Li Yang, Yi-Chun Liu, Jung-Chin Li, Yu-Nong Gong, Chung-Jan Kang, Shiang-Fu Huang, Ku-Hao Fang, Kai-Ping Chang, Li-Yu Lee, Chuen Hsueh, Shin-Ru Shih, Kuo-Chien Tsao
Human papillomavirus (HPV) infections predict mortality in Taiwanese patients with oral cavity squamous cell carcinoma (OCSCC). To address their prognostic significance for local recurrence (LR), in this retrospective cohort study we investigated different serologic and molecular markers of HPV 16 infection in 85 consecutive patients with primary OCSCC who received standard treatment and had their sera stored before treatment. Resected tumor specimens were examined with PCR-based assays for HPV 16 E6/E7 mRNA expression...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28414586/development-and-validation-of-monoclonal-antibody-based-antigen-capture-elisa-for-detection-of-group-a-porcine-rotavirus
#20
Atta Muhammad Memon, Anjuman Ara Bhuyan, Fangzhou Chen, Xiaozhen Guo, Harish Menghwar, Yinxing Zhu, Xugang Ku, Shuhua Chen, Zhonghua Li, Qigai He
Porcine rotavirus-A (PoRVA) is one of the common causes of mild to severe dehydrating diarrhea, leading to losses in weaning and postweaning piglets. A rapid, highly specific, and sensitive antigen-capture enzyme-linked immunosorbent assay (AC-ELISA) was developed for detection of PoRVA, by using VP6 (a highly conserved and antigenic protein of group-A rotavirus)-directed rabbit polyclonal antibodies (capture antibody) and murine monoclonal antibodies (detector antibody). The detection limit of AC-ELISA was found to be equal to that of conventional reverse transcription-polymerase chain reaction (RT-PCR; about 10(2...
May 2017: Viral Immunology
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