keyword
MENU ▼
Read by QxMD icon Read
search

Ro 52 antibody

keyword
https://www.readbyqxmd.com/read/27906879/presence-of-organ%C3%A2-specific-antibodies-in-patients-with-systemic-sclerosis
#1
Ewa Wielosz, Maria Majdan, Arkadiusz Koszarny, Magdalena Dryglewska, Jacek Tabarkiewicz
INTRODUCTION According to the literature, organ‑specific antibodies may be present in the course of systemic sclerosis (SSc). OBJECTIVES The aim of this study was to assess the prevalence of antithyroid antibodies (antithyroid peroxidase antibodies [anti‑TPO] and antithyroglobulin antibodies) and of antimitochondrial antibodies (AMAs), as well as to evaluate their clinical significance in patients with SSc. PATIENTS AND METHODS The study involved 86 consecutive in‑hospital patients with SSc (32 patients with diffuse cutaneous SSc [dcSSc] and 54 with limited cutaneous SSc [lcSSc])...
October 5, 2016: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/27848930/systemic-sclerosis-and-organ-specific-antibodies
#2
Ewa Wielosz, Maria Majdan, Arkadiusz Koszarny, Magdalena Dryglewska, Jacek Tabarkiewicz
INTRODUCTION    According to literature, some organ-specific antibodies may be present in systemic sclerosis (SSc).  OBJECTIVES    The objective of this study was to assess the prevalence of antithyroid antibodies (aTPO and/or aTG) and antimitochondrial antibodies (AMAs) in SSc patients (pts) moreover, to evaluate their clinical consequences.  PATIENTS AND METHODS    Analysis involved 86 consecutive patients with SSc hospitalized in the Department of Rheumatology; 32 patients had diffuse cutaneous (dcSSc) and 54 had limited cutaneous (lcSSc)...
October 5, 2016: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/27776552/scleroderma-and-dentistry-two-case-reports
#3
Shantanu Dixit, Chaithra Kalkur, Atul P Sattur, Michael M Bornstein, Fred Melton
BACKGROUND: Scleroderma is a chronic connective tissue disorder with unknown etiology. It is characterized by excessive deposition of extracellular matrix in the connective tissues causing vascular disturbances which can result in tissue hypoxia. These changes are manifested as atrophy of the skin and/or mucosa, subcutaneous tissue, muscles, and internal organs. Such changes can be classified into two types, namely, morphea (localized) and diffuse (systemic). Morphea can manifest itself as hemifacial atrophy (Parry-Romberg syndrome) although this remains debatable...
October 24, 2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27525944/expression-of-anti-srp19-antibody-in-muscle-tissues-from-patients-with-autoimmune-necrotizing-myopathy
#4
Q Wang, F Duan, P Liu, P F Wang, M X Wang
This study aimed to investigate the role of anti-SRP19 antibody in muscle tissues of patients with autoimmune necrotizing myopathy. Immunohistochemistry staining was used to determine the expression of anti-SRP19 antibodies in muscle tissues of autoimmune necrotizing myopathy patients. Results demonstrated that anti-SRP19 antibody was expressed in 71.4% (20/28) of muscle tissue specimens from patients with autoimmune necrotizing myopathy. Anti-SRP19 antibody expression was mainly localized in cytoplasm of necrotic muscle fibers surrounding the small blood vessels and interstitial cells...
2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27524195/-clinical-and-myopathological-features-of-jo-1-syndrome
#5
L C Meng, Y Li, W Zhang, H J Hao, F Gao, Y Yuan
OBJECTIVE: To report the clinical and myopathological features of 16 patients with Jo-1 syndrome. METHODS: Sixteen patients were recruited in this study, who were diagnosed as Jo-1 syndrome in Department of Neurology of Peking University First Hospital from January, 2011 to July, 2015. The clinical data and myopathological data were analyzed. RESULTS: The mean onset age was 41±14 (21-68) years old. 87.5% was female. The median duration was 9...
August 2, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/27494797/use-of-panel-testing-for-detection-of-antinuclear-antibody-in-a-resource-limited-setting-an-appraisal
#6
Ranjana Walker Minz, Yashwant Kumar, Biman Saikia, Shashi Anand, Subhash Varma, Surjit Singh
OBJECTIVES: Despite an increase in the incidence of systemic connective tissue diseases (CTD), panel testing for detection of antinuclear antibodies (ANA) is not a routine practice in many health centers of the Indian subcontinent. Consequently, the data on its significance is scanty. METHODS: To evaluate utility of panel testing, line immunoassay (LIA) and indirect immunofluorescence antinuclear antibody test (IIF-ANA) were performed in 321 cases of CTD. RESULTS: Out of 321 serum samples screened by the above tests, 227 were positive and 18 were negative by both LIA and IIF-ANA...
August 5, 2016: Postgraduate Medicine
https://www.readbyqxmd.com/read/27030700/arrhythmogenicity-of-anti-ro-ssa-antibodies-in-patients-with-torsades-de-pointes
#7
Pietro Enea Lazzerini, Yuankun Yue, Ujala Srivastava, Frank Fabris, Pier Leopoldo Capecchi, Iacopo Bertolozzi, Maria Romana Bacarelli, Gabriella Morozzi, Maurizio Acampa, Mariarita Natale, Nabil El-Sherif, Mauro Galeazzi, Franco Laghi-Pasini, Mohamed Boutjdir
BACKGROUND: In patients with autoimmune disease, anti-Ro/SSA antibodies (anti-Ro/SSA) are responsible for a novel autoimmune-associated long-QT syndrome by targeting the hERG potassium channel and inhibiting the related current (IKr). Because anti-Ro/SSA are also present in a significant proportion of healthy subjects and may be associated with torsades de pointes (TdP) arrhythmia, we tested the hypothesis that anti-Ro/SSA may represent a silent risk factor in patients developing TdP...
April 2016: Circulation. Arrhythmia and Electrophysiology
https://www.readbyqxmd.com/read/26956184/comparison-of-antibody-assays-for-detection-of-autoantibodies-to-ro-52-ro-60-and-la-associated-with-primary-sj%C3%A3-gren-s-syndrome
#8
Nicole Hartwig Trier, Inger Ødum Nielsen, Tina Friis, Gunnar Houen, Elke Theander
Anti-Ro(52/60) and anti-La constitute the hallmark autoantibodies in primary Sjögren's syndrome, being present in 40-70% of sera. Several anti-Ro/La assays exist, but antibody detection appears to be assay-specific, thus the aim of this study was to compare several anti-Ro/La assays. In total, 96 sera from individuals with primary Sjögren's syndrome and 114 healthy controls were tested for anti-Ro 52/60 and anti-La in 17 immunoassays. Especially the immunoassays used for detection of anti-Ro 52 differed in their sensitivity (48-79%), while only small differences in sensitivities were observed for the anti-Ro 60 (69-77%) anti-La (39-44%) assays...
June 2016: Journal of Immunological Methods
https://www.readbyqxmd.com/read/26753209/-evaluation-of-usefulness-of-polycheck-method-in-the-detection-autoantibodies-in-patients-with-systemic-lupus-erythematosus-sj%C3%A3-gren-s-syndrome-and-systemic-sclerosis
#9
Magdalena Dryglewskal, Maria Majdan, Arkadiusz Koszarny, Aleksandra Grytal, Maciej Grzywnowicz
INTRODUCTION: To recognize the connective tissue diseases (CTD), which include lupus erythematosus (SLE), Sjögren's syndrome (SS) and Systemic sclerosis (SSc) it is necessary to determine the presence of autoantibodies (Ab). There is still work going on to find effective and equivocal detection methods. THE AIM OF STUDY: To evaluate the usefulness, clinical value and innovativeness of the Polycheck method in the detection of autoantibodies in patients with connective tissue diseases...
2015: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/26676808/infliximab-induced-autoantibodies-a-multicenter-study
#10
João Luiz Pereira Vaz, Vander Fernandes, Felipe Nogueira, Adriano Arnóbio, Roger A Levy
The purpose of this study was to assess autoantibody incidence in patients treated with infliximab for various diseases, and the development of autoimmune diseases using a multicenter, longitudinal, open-label, phase IV observational study. All patients received anti-tumor necrosis factor (anti-TNF) according to local treatment guidelines. The autoantibodies assessed before and after infliximab treatment were ANA, anti-Sm, anti-dsDNA, anticardiolipin IgM/IgG, anti-Scl70, anti-centromere B, anti-chromatin, anti-ribosomal P, anti-Sm-RNP, anti-RNP A, anti-RNP 68 kD, anti-La/SSB, anti-Ro/SSA 52 kD and 60 kD, and anti-Jo1...
February 2016: Clinical Rheumatology
https://www.readbyqxmd.com/read/26617847/nonspecific-interstitial-pneumonia-overlaps-organizing-pneumonia-in-lung-dominant-connective-tissue-disease
#11
REVIEW
Xue-Ren Li, Shou-Chun Peng, Lu-Qing Wei
Here, we reported two cases of nonspecific interstitial pneumonia overlap organizing pneumonia (NSIP/OP) with lung-dominant connective tissue disease (LD-ILD). The first case is a patient with hands of chapped skin, right-sided pleuritic chest discomfort, weakness, positive ANA and antibodies to Ro/SS-A (+++) and Ro-52 (++). In the second case, there were Reynaud's disease, and nucleolus-ANA increased (1:800). Chest high resolution CT scan in both cases showed ground-glass opacifications, predominantly in basal and subpleural region and the pathologic manifestation were correlated with NSIP/OP, which were previously discovered in Sjogren syndrome, PM/DM and other rheumatic diseases...
2015: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/26547884/identification-of-specific-antinuclear-antibodies-in-dogs-using-a-line-immunoassay-and-enzyme-linked-immunosorbent-assay
#12
Hanna D Bremer, Erik Lattwein, Stefanie Renneker, Inger Lilliehöök, Johan Rönnelid, Helene Hansson-Hamlin
Circulating antinuclear antibodies (ANA) are commonly present in the systemic autoimmune disease Systemic Lupus Erythematosus (SLE) and in other systemic rheumatic diseases, in humans as well as in dogs. The indirect immunofluorescence (IIF)-ANA test is the standard method for detecting ANA. Further testing for specific ANA with immunoblot techniques or ELISAs is routinely performed in humans to aid in the diagnosis and monitoring of disease. Several specific ANA identified in humans have been identified also in suspected canine SLE but, in contrast to humans, investigation of autoantibodies in canine SLE is mainly restricted to the IIF-ANA test...
December 15, 2015: Veterinary Immunology and Immunopathology
https://www.readbyqxmd.com/read/26506673/interstitial-lung-disease-as-first-clinical-manifestation-within-the-antisynthetase-syndrome-dermatomyositis
#13
Daniel Trăilă, Ovidiu Fira Mlădinescu, Cristian Oancea, Voicu Tudorache
Diffuse interstitial pneumopathies within the diseases of the connective tissue are often a diagnosis challenge, sometimes being the initial or dominant manifestation of the underlying autoimmune disease. The case of a young man shall be presented with relatively quick dyspnoea which has appeared under the conditions of an efficient physical status and without any notable pathological history. The cause of the dyspnoea is found to be a interstitial lung disease with radiological and histopathological pattern of non-specific interstitial pneumonia...
2015: Pneumologia: Revista Societății Române de Pneumologie
https://www.readbyqxmd.com/read/26496247/pediatric-patients-with-vitiligo-in-eastern-china-abnormalities-in-145-cases-based-on-thyroid-function-tests-and-immunological-findings
#14
Cheng Xianfeng, Jiang Yuegen, Yin Zhiyu, Yang Yan, Zeng Xuesi, Wang Fenglai, Li Ansheng, Wang Wei
BACKGROUND: The aim of this study was to evaluate abnormalities in thyroid function according to tests and the humoral immune systems of patients from Eastern China with pediatric vitiligo. MATERIAL AND METHODS: A total of 145 pediatric patients with vitiligo were investigated in this study, along with 59 children without autoimmune diseases as controls. Laboratory tests of thyroid function were conducted, and these tests examined free triiodothyronine (FT3), free thyroxine (FT4), thyroid stimulating hormone (TSH), thyroglobulin antibody (TG-Ab), thyroid peroxidase antibody (TPO-Ab), antinuclear antibodies (ANAs), immunoglobulins (IgA, IgM, and IgG), and complements (C3 and C4)...
2015: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/26109563/prediction-of-sj%C3%A3-gren-s-syndrome-years-before-diagnosis-and-identification-of-patients-with-early-onset-and-severe-disease-course-by-autoantibody-profiling
#15
Elke Theander, Roland Jonsson, Bitte Sjöström, Karl Brokstad, Peter Olsson, Gunnel Henriksson
OBJECTIVE: Autoantibodies are highly characteristic of primary Sjögren's syndrome (SS) and represent important tools for studying its pathogenesis. Nonetheless, thus far, no systematic investigations have assessed the presence of autoantibodies before diagnosis. This study was undertaken to analyze how early and in what order autoantibodies appear, how predictive they are of primary SS, and whether they identify disease subsets. METHODS: A nested case-control design linking data from the Malmö primary SS registry and 3 Swedish healthcare biobanks was applied...
September 2015: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/26022620/a-cross-sectional-study-of-autoantibody-profiles-in-the-waikato-systemic-sclerosis-cohort-new-zealand
#16
Winston S J Chang, Joanna Schollum, Douglas H N White, Kamal K Solanki
The autoantibody profiles in New Zealand systemic sclerosis patients have not previously been reported. The aim of this study was to evaluate the autoantibody profiles of patients in the Waikato Hospital Systemic Sclerosis Clinic cohort. The EUROLINE (IgG) Systemic Sclerosis panel test kit (which tests for Scl-70, CENP-A, CENP-B, RP11, RP155, Fib, NOR90, Th/To, PM100, PM75, Ku, PDGFR and Ro-52) was selected for the purpose of this study. All patients attending the Waikato Hospital Systemic Sclerosis clinic were invited to participate...
November 2015: Clinical Rheumatology
https://www.readbyqxmd.com/read/25995318/pathogenesis-of-the-novel-autoimmune-associated-long-qt-syndrome
#17
Yuankun Yue, Monica Castrichini, Ujala Srivastava, Frank Fabris, Krupa Shah, Zhiqiang Li, Yongxia Qu, Nabil El-Sherif, Zhengfeng Zhou, Craig January, M Mahmood Hussain, Xian-Cheng Jiang, Eric A Sobie, Marie Wahren-Herlenius, Mohamed Chahine, Pier-Leopoldo Capecchi, Franco Laghi-Pasini, Pietro-Enea Lazzerini, Mohamed Boutjdir
BACKGROUND: Emerging clinical evidence demonstrates high prevalence of QTc prolongation and complex ventricular arrhythmias in patients with anti-Ro antibody (anti-Ro Ab)-positive autoimmune diseases. We tested the hypothesis that anti-Ro Abs target the HERG (human ether-a-go-go-related gene) K(+) channel, which conducts the rapidly activating delayed K(+) current, IKr, thereby causing delayed repolarization seen as QT interval prolongation on the ECG. METHODS AND RESULTS: Anti-Ro Ab-positive sera, purified IgG, and affinity-purified anti-52kDa Ro Abs from patients with autoimmune diseases and QTc prolongation were tested on IKr using HEK293 cells expressing HERG channel and native cardiac myocytes...
July 28, 2015: Circulation
https://www.readbyqxmd.com/read/25972968/lung-dominant-connective-tissue-disease-among-patients-with-interstitial-lung-disease-prevalence-functional-stability-and-common-extrathoracic-features
#18
Daniel Antunes Silva Pereira, Olívia Meira Dias, Guilherme Eler de Almeida, Mariana Sponholz Araujo, Letícia Barbosa Kawano-Dourado, Bruno Guedes Baldi, Ronaldo Adib Kairalla, Carlos Roberto Ribeiro Carvalho
OBJECTIVE: To describe the characteristics of a cohort of patients with lung-dominant connective tissue disease (LD-CTD). METHODS: This was a retrospective study of patients with interstitial lung disease (ILD), positive antinuclear antibody (ANA) results (≥ 1/320), with or without specific autoantibodies, and at least one clinical feature suggestive of connective tissue disease (CTD). RESULTS: Of the 1,998 patients screened, 52 initially met the criteria for a diagnosis of LD-CTD: 37% were male; the mean age at diagnosis was 56 years; and the median follow-up period was 48 months...
March 2015: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/25865002/clinical-and-immunological-characteristics-in-552-systemic-lupus-erythematosus-patients-in-a-southern-province-of-china
#19
Wen-Gen Li, Zhi-Zhong Ye, Zhi-Hua Yin, Ke Zhang
AIM: The purpose of this study was to gain a better understanding of systemic lupus erythematosus (SLE) in Hakka populations. METHODS: We studied the demographic, clinical and laboratory characteristics in a cohort of 552 SLE patients diagnosed at the Rheumatology Department in MeiZhou People's Hospital from January 2008 to December 2012. There were 495 women and 57 men (8.7 : 1) with a mean age of 35.3 years (range 12-78 years). The mean age at disease onset and the mean disease duration were 31...
April 10, 2015: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/25825254/plasma-exchange-effectively-removes-52-and-60-kda-anti-ro-ssa-and-anti-la-ssb-antibodies-in-pregnant-women-with-congenital-heart-block
#20
Marta Tonello, Amelia Ruffatti, Piero Marson, Tiziana Tison, Luca Marozio, Ariela Hoxha, Giustina De Silvestro, Leonardo Punzi
BACKGROUND: Pregnant women positive for 52- and 60-kDa anti-Ro/SSA and anti-La/SSB antibodies can suffer from congenital heart block (CHB), a passively acquired autoimmune disease. STUDY DESIGN AND METHODS: We evaluated the efficacy of plasma exchange (PE) in removing 52- and 60-kDa anti-Ro/SSA and anti-La/SSB antibodies in pregnant women with CHB treated with a combined therapy including PE, intravenous immunoglobulins, and steroids. Antibody levels were monitored in 10 consecutive pregnant women diagnosed with CHB and prospectively followed between 2009 and 2013...
July 2015: Transfusion
keyword
keyword
90316
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"