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https://www.readbyqxmd.com/read/29145345/the-role-of-sativex-in-robotic-rehabilitation-in-individuals-with-multiple-sclerosis-rationale-study-design-and-methodology
#1
Margherita Russo, Vincenzo Dattola, Anna Lisa Logiudice, Rosella Ciurleo, Edoardo Sessa, Rosaria De Luca, Placido Bramanti, Alessia Bramanti, Antonino Naro, Rocco Salvatore Calabrò
INTRODUCTION: Currently, none of the available multiple sclerosis (MS) disease-modifying medications has been shown to stop or reverse gait disability. Recently, the nabiximols has been tested for the treatment of spasticity and walking impairment in MS. Nabiximols (trade name Sativex) is an oromucosal spray formulation containing 1:1 fixed ratio of delta-9-tetrahydrocannabinol and cannabidiol derived from cloned Cannabis sativa L. plant. METHOD AND ANALYSIS: A single-center, prospective, parallel design, single-blind trial will be conducted at the IRCCS Neurolesi "Bonino-Pulejo" (Italy) involving MS patients affected by spasticity and undergoing a Robotic Rehabilitation training...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29144568/kinematic-analysis-of-pressing-situations-in-female-collegiate-football-games-new-insight-into-acl-injury-causation
#2
Shogo Sasaki, Hideyuki Koga, Tron Krosshaug, Satoshi Kaneko, Toru Fukubayashi
The most common events during which anterior cruciate ligament (ACL) injuries occur in football are pressing situations. This study aimed to describe the knee and hip joint kinematics during pressing situations in football games in order to identify kinematic patterns in actions with a high risk for ACL injuries. We filmed 5 female collegiate football matches and identified 66 pressing situations. Five situations with a large distance between the trunk and foot placements in the sagittal plane were analysed using a model-based image-matching technique...
November 16, 2017: Scandinavian Journal of Medicine & Science in Sports
https://www.readbyqxmd.com/read/29143300/effect-of-restraining-the-base-of-support-on-the-other-biomechanical-features-in-patients-with-cerebellar-ataxia
#3
C Conte, Mariano Serrao, L Cuius, A Ranavolo, S Conforto, F Pierelli, L Padua
This study aimed to analyze the biomechanical consequences of reducing the base of support in patients with ataxia. Specifically, we evaluated the spatio-temporal parameters, upper- and lower-body kinematics, muscle co-activation, and energy recovery and expenditure. The gaits of 13 patients were recorded using a motion analysis system in unperturbed and perturbed walking conditions. In the latter condition, patients had to walk using the same step width and speed of healthy controls. The perturbed walking condition featured reduced gait speed, step length, hip and knee range of motion, and energy recovery and increased double support duration, gait variability, trunk oscillation, and ankle joint muscle co-activation...
November 15, 2017: Cerebellum
https://www.readbyqxmd.com/read/29142272/individuals-of-the-common-namib-day-gecko-vary-in-how-adaptive-simplification-alters-sprint-biomechanics
#4
Clint E Collins, Timothy E Higham
Locomotion inextricably links biomechanics to ecology as animals maneuver through mechanically challenging environments. Faster individuals are more likely to escape predators, surviving to produce more offspring. Fast sprint speed evolved several times in lizards, including geckos. However, the underlying mechanisms determining performance await discovery in many clades. Novel morphological structures influence these mechanisms by adding complexity to the government of locomotion. Gecko adhesion coevolves with modified muscles, tendons, and reflexes...
November 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29142016/multi-scale-tarsal-adhesion-kinematics-of-freely-walking-dock-beetles
#5
Sophie Marie Gernay, Simon Labousse, Pierre Lambert, Philippe Compère, Tristan Gilet
In this experimental study, living dock beetles are observed during their free upside-down walk on a smooth horizontal substrate. Their weight is balanced by the adhesion of hairy structures present on their tarsomeres. The motions involved in the attachment and detachment of these structures were characterized by simultaneously imaging the beetle from the side at the body scale, and from the top at the scale of a single tarsal chain. The observed multi-scale three-dimensional kinematics of the tarsi is qualitatively described, then quantified by image processing and physically modelled...
November 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/29141811/do-gait-patterns-differ-in-men-and-women-with-multiple-sclerosis
#6
Massimiliano Pau, Federica Corona, Giuseppina Pilloni, Micaela Porta, Giancarlo Coghe, Eleonora Cocco
BACKGROUND: Multiple Sclerosis (MS) affects men and women differently from several points of view: prevalence, severity of cognitive impairments and disability accumulation. However, it is unknown whether ambulatory dysfunctions are sex-related. This study investigated the existence of differences in spatio-temporal and kinematic parameters of gait in men and women with MS using 3D gait analysis. METHODS: Gait patterns of 60 people with MS (pwMS, 32F, 28M) with low to moderate disability (average Expanded Disability Status Scale score 3, range 1-5...
November 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29141615/kinematic-characterization-of-clinically-observed-aberrant-movement-patterns-in-patients-with-non-specific-low-back-pain-a-cross-sectional-study
#7
Peemongkon Wattananon, David Ebaugh, Scott A Biely, Susan S Smith, Gregory E Hicks, Sheri P Silfies
BACKGROUND: Clinical observation of aberrant movement patterns during active forward bending is one criterion used to identify patients with non-specific low back pain suspected to have movement coordination impairment. The purpose of this study was to describe and quantify kinematic patterns of the pelvis and trunk using a dynamics systems approach, and determine agreement between clinical observation and kinematic classification. METHOD: Ninety-eight subjects performed repeated forward bending with clinical observation and kinematic data simultaneously collected...
November 15, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29140533/come-together-human-avatar-on-line-interactions-boost-joint-action-performance-in-apraxic-patients
#8
Matteo Candidi, Lucia M Sacheli, Vanessa Era, Loredana Canzano, Gaetano Tieri, Salvatore M Aglioti
Limb apraxia (LA) is a high-order motor disorder linked to left-hemisphere damage. It is characterized by defective execution of purposeful actions upon delayed imitation, or verbal command when the actions are performed in isolated, non-naturalistic, conditions. Whether interpersonal interactions provide social affordances that activate neural resources different from those requested by individual action execution, which may improve LA performance, is unknown. To fill this gap, we measured interaction performance, behavioral and kinematic indexes of left-brain damaged patients with/without LA in a social reach-to-grasp task involving two different degrees of spatio-temporal interactivity with an avatar...
November 1, 2017: Social Cognitive and Affective Neuroscience
https://www.readbyqxmd.com/read/29140190/evaluation-of-a-shoulder-injury-prevention-program-in-wheelchair-basketball
#9
Jereme Wilroy, Elizabeth Hibberd
CONTEXT: Previous literature has theorized that alterations in shoulder physical characteristics are present in wheelchair athletes and contribute to shoulder pain and injury. Limited empirical evidence is present that evaluates the effectiveness of a shoulder injury prevention program focusing on improving these altered characteristics. OBJECTIVE: To evaluate the effectiveness of a 6-week intervention program at improving characteristics that increases the risk of developing pain or shoulder injury...
November 15, 2017: Journal of Sport Rehabilitation
https://www.readbyqxmd.com/read/29139573/gait-patterns-symptoms-and-function-in-patients-with-isolated-tibiofemoral-osteoarthritis-and-combined-tibiofemoral-and-patellofemoral-osteoarthritis
#10
Harvi F Hart, Kay M Crossley, Michael A Hunt
The purpose of this study was to compare hip and knee biomechanics during walking in individuals with isolated TFOA, combined TFOA and PFOA, and those without knee OA, and to compare patient-reported symptoms and function in individuals with isolated TFOA and those with combined TFOA and PFOA. Participants with and without knee OA were assessed and categorized into (i) no OA, (ii) isolated TFOA, and (iii) combined TFOA and PFOA, based on Kellgren and Lawrence diagnostic criteria. Quantitative motion analyses were conducted during walking, and hip and knee kinematics and external moments were calculated...
November 15, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29139570/distribution-of-segmental-foot-kinematics-in-patients-with-degenerative-joint-disease-of-the-ankle
#11
Karl Canseco, Karen M Kruger, Jessica M Fritz, Katherine A Konop, Sergey Tarima, Richard M Marks, Gerald F Harris
Degenerative joint disease (DJD) of the ankle is a debilitating chronic disease associated with severe pain and dysfunction resulting in antalgic gait alteration. Little information is available about segmental foot and ankle motion distribution during gait in ankle osteoarthritis. The aim of the current study was to dynamically characterize segmental foot and ankle kinematics of patients with severe ankle arthrosis requiring total ankle replacement. This was a prospective study involving 36 (19 M, 17 F) adult patients with a clinical diagnosis of ankle arthrosis ("DJD" group) and 36 (23 M, 13 F) healthy subjects ("Control" group)...
November 15, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29139331/kinematic-modeling-of-a-7-degree-of-freedom-spatial-hybrid-manipulator-for-medical-surgery
#12
Amanpreet Singh, Ekta Singla, Sanjeev Soni, Ashish Singla
The prime objective of this work is to deal with the kinematics of spatial hybrid manipulators. In this direction, in 1955, Denavit and Hartenberg proposed a consistent and concise method, known as D-H parameters method, to deal with kinematics of open serial chains. From literature review, it is found that D-H parameter method is widely used to model manipulators consisting of lower pairs. However, the method leads to ambiguities when applied to closed-loop, tree-like and hybrid manipulators. Furthermore, in the dearth of any direct method to model closed-loop, tree-like and hybrid manipulators, revisions of this method have been proposed from time-to-time by different researchers...
November 1, 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29137725/a-gait-retraining-system-using-augmented-reality-to-modify-footprint-parameters-effects-on-lower-limb-sagittal-plane-kinematics
#13
Sami Bennour, Baptiste Ulrich, Thomas Legrand, Brigitte M Jolles, Julien Favre
Improving lower-limb flexion/extension angles during walking is important for the treatment of numerous pathologies. Currently, these gait retraining procedures are mostly qualitative, often based on visual assessment and oral instructions. This study aimed to propose an alternative method combining motion capture and display of target footprints on the floor. The second objectives were to determine the error in footprint modifications and the effects of footprint modifications on lower-limb flexion/extension angles...
November 11, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29137624/compression-rate-dependent-nonlinear-mechanics-of-normal-and-impaired-porcine-knee-joints
#14
Marcel Leonardo Rodriguez, LePing Li
BACKGROUND: The knee joint performs mechanical functions with various loading and unloading processes. Past studies have focused on the kinematics and elastic response of the joint with less understanding of the rate-dependent load response associated with viscoelastic and poromechanical behaviors. METHODS: Forty-five fresh porcine knee joints were used in the present study to determine the loading-rate-dependent force-compression relationship, creep and relaxation of normal, dehydrated and meniscectomized joints...
November 14, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/29135783/beyond-the-bottom-of-the-foot-topographic-organization-of-the-foot-dorsum-in-walking
#15
Taryn Klarner, Gregory E P Pearcey, Yao Sun, Trevor S Barss, Chelsea Kaupp, Bridget Munro, Nick Frank, E Paul Zehr
INTRODUCTION: Sensory feedback from the foot dorsum during walking has only been studied globally by whole nerve stimulation. Stimulating the main nerve innervating the dorsal surface produces a functional stumble corrective response that is phase-dependently modulated. We speculated that effects evoked by activation of discrete skin regions on the foot dorsum would be topographically organized, as with the foot sole. METHODS: Nonnoxious electrical stimulation was delivered to five discrete locations on the dorsal surface of the foot during treadmill walking...
December 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29134200/intraoceanic-subduction-spanned-the-pacific-in-the-late-cretaceous-paleocene
#16
Mathew Domeier, Grace E Shephard, Johannes Jakob, Carmen Gaina, Pavel V Doubrovine, Trond H Torsvik
The notorious ~60° bend separating the Hawaiian and Emperor chains marked a prominent change in the motion of the Pacific plate at ~47 Ma (million years ago), but the origin of that change remains an outstanding controversy that bears on the nature of major plate reorganizations. Lesser known but equally significant is a conundrum posed by the pre-bend (~80 to 47 Ma) motion of the Pacific plate, which, according to conventional plate models, was directed toward a fast-spreading ridge, in contradiction to tectonic forcing expectations...
November 2017: Science Advances
https://www.readbyqxmd.com/read/29134124/the-design-and-implementation-of-the-software-tracking-cervical-and-lumbar-vertebrae-in-spinal-fluoroscopy-images
#17
Behrouz Alizadeh Savareh, Yousef Sadat, Azadeh Bashiri, Mehraban Shahi, Nasrin Davaridolatabadi
Aim: Manual analysis of neck kinematics is usually associated with measurement errors and it requires the use of software capabilities. Considering laboratory usage, software has been developed to solve the associated problems. Materials & methods: Fluoroscopic images taken from 78 women were used to design and evaluate the performance of the software. The software was implemented using C# language, according to the case-based reasoning technique. Results: The viewpoints of experts suggest accuracy of the software in tracking and calculations, which meets their information requirements...
November 2017: Future Science OA
https://www.readbyqxmd.com/read/29134103/allometry-of-wing-twist-and-camber-in-a-flower-chafer-during-free-flight-how-do-wing-deformations-scale-with-body-size
#18
Yonatan Meresman, Gal Ribak
Intraspecific variation in adult body mass can be particularly high in some insect species, mandating adjustment of the wing's structural properties to support the weight of the larger body mass in air. Insect wings elastically deform during flapping, dynamically changing the twist and camber of the relatively thin and flat aerofoil. We examined how wing deformations during free flight scale with body mass within a species of rose chafers (Coleoptera: Protaetia cuprea) in which individuals varied more than threefold in body mass (0...
October 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29134100/three-dimensional-innate-mobility-of-the-human-foot-bones-under-axial-loading-using-biplane-x-ray-fluoroscopy
#19
Kohta Ito, Koh Hosoda, Masahiro Shimizu, Shuhei Ikemoto, Takeo Nagura, Hiroyuki Seki, Masateru Kitashiro, Nobuaki Imanishi, Sadakazu Aiso, Masahiro Jinzaki, Naomichi Ogihara
The anatomical design of the human foot is considered to facilitate generation of bipedal walking. However, how the morphology and structure of the human foot actually contribute to generation of bipedal walking remains unclear. In the present study, we investigated the three-dimensional kinematics of the foot bones under a weight-bearing condition using cadaver specimens, to characterize the innate mobility of the human foot inherently prescribed in its morphology and structure. Five cadaver feet were axially loaded up to 588 N (60 kgf), and radiographic images were captured using a biplane X-ray fluoroscopy system...
October 2017: Royal Society Open Science
https://www.readbyqxmd.com/read/29133812/surge-type-and-surge-modified-glaciers-in-the-karakoram
#20
R Bhambri, K Hewitt, P Kawishwar, B Pratap
Glaciers in the Karakoram exhibit irregular behavior. Terminus fluctuations of individual glaciers lack consistency and, unlike other parts of the Himalaya, total ice mass remained stable or slightly increased since the 1970s. These seeming anomalies are addressed through a comprehensive mapping of surge-type glaciers and surge-related impacts, based on satellite images (Landsat and ASTER), ground observations, and archival material since the 1840s. Some 221 surge-type and surge-like glaciers are identified in six main classes...
November 13, 2017: Scientific Reports
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