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https://www.readbyqxmd.com/read/29786075/tp53-gain-of-function-mutation-promotes-inflammation-in-glioblastoma
#1
Seok Won Ham, Hee-Young Jeon, Xiong Jin, Eun-Jung Kim, Jun-Kyum Kim, Yong Jae Shin, Yeri Lee, Se Hoon Kim, Seon Yong Lee, Sunyoung Seo, Min Gi Park, Hye-Mi Kim, Do-Hyun Nam, Hyunggee Kim
Glioblastoma (GBM), the most severe and common brain tumor in adults, is characterized by multiple somatic mutations and aberrant activation of inflammatory responses. Immune cell infiltration and subsequent inflammation cause tumor growth and resistance to therapy. Somatic loss-of-function mutations in the gene encoding tumor suppressor protein p53 (TP53) are frequently observed in various cancers. However, numerous studies suggest that TP53 regulates malignant phenotypes by gain-of-function (GOF) mutations...
May 21, 2018: Cell Death and Differentiation
https://www.readbyqxmd.com/read/29785965/inflammatory-bowel-disease-increases-the-risk-of-parkinson-s-disease-a-danish-nationwide-cohort-study-1977-2014
#2
Marie Villumsen, Susana Aznar, Bente Pakkenberg, Tine Jess, Tomasz Brudek
OBJECTIVE: Intestinal inflammation has been suggested to play a role in development of Parkinson's disease (PD) and multiple system atrophy (MSA). To test the hypothesis that IBD is associated with risk of PD and MSA, we performed a nationwide population-based cohort study. DESIGN: The cohort consisted of all individuals diagnosed with IBD in Denmark during 1977-2014 (n=76 477) and non-IBD individuals from the general population, who were comparable in terms of gender, age and vital status (n=7 548 259)...
May 21, 2018: Gut
https://www.readbyqxmd.com/read/29783199/inhalational-exposure-to-particulate-matter-air-pollution-alters-the-composition-of-the-gut-microbiome
#3
Ece A Mutlu, Işın Y Comba, Takugo Cho, Phillip A Engen, Cemal Yazıcı, Saul Soberanes, Robert B Hamanaka, Recep Niğdelioğlu, Angelo Y Meliton, Andrew J Ghio, G R Scott Budinger, Gökhan M Mutlu
Recent studies suggest an association between particulate matter (PM) air pollution and gastrointestinal (GI) disease. In addition to direct deposition, PM can be indirectly deposited in oropharynx via mucociliary clearance and upon swallowing of saliva and mucus. Within the GI tract, PM may alter the GI epithelium and gut microbiome. Our goal was to determine the effect of PM on gut microbiota in a murine model of PM exposure via inhalation. C57BL/6 mice were exposed via inhalation to either concentrated ambient particles or filtered air for 8-h per day, 5-days a week, for a total of 3-weeks...
May 18, 2018: Environmental Pollution
https://www.readbyqxmd.com/read/29775230/alcohol-enhances-symptoms-and-propensity-for-infection-in-inflammatory-bowel-disease-patients-and-a-murine-model-of-dss-induced-colitis
#4
Abigail R Cannon, Paulius V Kuprys, Adrienne N Cobb, Xianzhong Ding, Anai N Kothari, Paul C Kuo, Joshua M Eberhardt, Adam M Hammer, Niya L Morris, Xiaoling Li, Mashkoor A Choudhry
Over 1.4 million Americans have been diagnosed with inflammatory bowel disease (IBD), and ulcerative colitis (UC) makes up approximately half of those diagnoses. As a disease, UC cycles between periods of remission and flare, which is characterized by intense abdominal pain, increased weight loss, intestinal inflammation, rectal bleeding, and dehydration. Interestingly, a widespread recommendation to IBD patients for avoidance of a flare period is "Don't Drink Alcohol" as recent work correlated alcohol consumption with increased GI symptoms in patients with IBD...
May 18, 2018: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/29767701/microbiome-mediated-effects-of-the-mediterranean-diet-on-inflammation
#5
Melisa A Bailey, Hannah D Holscher
The Mediterranean diet pattern is increasingly associated with improved metabolic health. Two mechanisms by which consuming a Mediterranean diet pattern may contribute to improved metabolic health are modulation of the gastrointestinal (GI) microbiota and reduction of metabolic endotoxemia. Metabolic endotoxemia, defined as a 2- to 3-fold increase in circulating levels of bacterial endotoxin, has been proposed as a cause of inflammation during metabolic dysfunction. As the largest source of endotoxins in the human body, the GI microbiota represents a crucial area for research on strategies for reducing endotoxemia...
May 1, 2018: Advances in Nutrition
https://www.readbyqxmd.com/read/29760697/hookworm-secreted-extracellular-vesicles-interact-with-host-cells-and-prevent-inducible-colitis-in-mice
#6
Ramon M Eichenberger, Stephanie Ryan, Linda Jones, Geraldine Buitrago, Ramona Polster, Marcela Montes de Oca, Jennifer Zuvelek, Paul R Giacomin, Lindsay A Dent, Christian R Engwerda, Matthew A Field, Javier Sotillo, Alex Loukas
Gastrointestinal (GI) parasites, hookworms in particular, have evolved to cause minimal harm to their hosts, allowing them to establish chronic infections. This is mediated by creating an immunoregulatory environment. Indeed, hookworms are such potent suppressors of inflammation that they have been used in clinical trials to treat inflammatory bowel diseases (IBD) and celiac disease. Since the recent description of helminths (worms) secreting extracellular vesicles (EVs), exosome-like EVs from different helminths have been characterized and their salient roles in parasite-host interactions have been highlighted...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29757462/effect-of-guava-and-vitamin-c-supplementation-on-experimental-gingivitis-a-randomized-clinical-trial
#7
Amaliya Amaliya, Ajeng S Risdiana, Ubele Van der Velden
OBJECTIVE: To study the effect of guava and synthetic vitamin C on the development of gingival inflammation during experimental gingivitis. MATERIAL AND METHODS: Participants were randomly assigned to three groups supplemented daily with either 200g guava, 200mg synthetic vitamin C or water. The study included a 14 days pre-experimental period with oral hygiene instructions, scaling, prophylaxis and supplementation. Thereafter, experiment gingivitis was initiated, while continuing supplementation...
May 14, 2018: Journal of Clinical Periodontology
https://www.readbyqxmd.com/read/29751049/increased-butyrate-priming-in-the-gut-stalls-microbiome-associated-gastrointestinal-inflammation-and-hepatic-metabolic-reprogramming-in-a-mouse-model-of-gulf-war-illness
#8
Ratanesh Kumar Seth, Diana Kimono, Firas Alhasson, Sutapa Sarkar, Muayad Albadrani, Stephen K Lasley, Ronnie Horner, Patricia Janulecewicz, Mitzi Nagarkatti, Prakash Nagarkatti, Kimberly Sullivan, Saurabh Chatterjee
Most of the associated pathologies in Gulf War Illness (GWI) have been ascribed to chemical and pharmaceutical exposures during the war. Since an increased number of veterans complain of gastrointestinal (GI), neuroinflammatory and metabolic complications as they age and there are limited options for a cure, the present study was focused to assess the role of butyrate, a short chain fatty acid for attenuating GWI-associated GI and metabolic complications. Results in a GWI-mouse model of permethrin and pyridostigmine bromide (PB) exposure showed that oral butyrate restored gut homeostasis and increased GPR109A receptor copies in the small intestine (SI)...
May 8, 2018: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/29740969/peripheral-cannabinoid-1-receptor-blockade-mitigates-adipose-tissue-inflammation-via-nlrp3-inflammasome-in-mouse-models-of-obesity
#9
Ji Hye Han, Hanho Shin, Jun Gi Rho, Jung-Eun Kim, Dong Hwee Son, Juhwan Yoon, Yong Jae Lee, Jung-Hyuck Park, Byung Jeong Song, Chang-Sik Choi, Seul Gi Yoon, Il Yong Kim, Eun Kyung Lee, Je Kyung Seong, Ki Woo Kim, Wook Kim
AIMS: Cannabinoid 1 receptor (CB1R) antagonists have been shown to improve insulin resistance and the associated metabolic abnormalities, but their therapeutic development was discontinued due to neuropsychiatric side effects. This study evaluated AJ5018 as the peripherally restricted CB1R antagonist, synthesized by modifying the structure of its brain-penetrant parent compound rimonabant, and analyzed the metabolic parameters and adipose tissue inflammation via NLRP3 inflammasome following chronic treatment of mouse models of obesity with AJ5018...
May 8, 2018: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29732532/pathogenesis-diagnosis-and-treatment-of-anaemia-in-immune-mediated-gastrointestinal-disorders
#10
REVIEW
Gaetano Bergamaschi, Antonio Di Sabatino, Gino R Corazza
Immune-mediated disorders affecting the gastrointestinal (GI) tract may compromise GI integrity, interfere with the absorption of nutrients and cause bleeding and inflammation. All these features contribute to the pathogenesis of anaemia, the most prevalent extra-intestinal manifestation of immune-mediated GI disorders. Anaemia is most commonly due to iron deficiency and/or inflammation, but vitamin deficiencies and, more infrequently, autoimmune haemolysis or drug-induced myelosuppression can be involved. Here we address several issues related to the differential diagnosis and treatment of anaemia in immune-mediated GI disorders, giving particular relevance to the problem of iron deficiency anaemia associated with inflammation...
May 6, 2018: British Journal of Haematology
https://www.readbyqxmd.com/read/29720329/effect-of-dental-care-on-the-oral-health-of-sj%C3%A3-gren%C3%A2-s-syndrome-patients
#11
A Lucchese, M Portelli, M Marcolina, P F Nocini, G Caldara, D Bertossi, C Lucchese, U Tacchino, M Manuelli
Sjögren’s syndrome (SS) is a chronic, systemic autoimmune disease affecting the exocrine glands, particularly the salivary and lacrimal glands. Xerostomia is a major feature of this syndrome and greatly affects patient quality of life. The most typical clinical signs associated with hyposalivation are dysgeusia and dysosmia, dental caries, candidiasis, periodontal disease, gland inflammation, mucositis and oral ulcers. The aims are to investigate on Plaque Index (PI) and Gingival Index (GI) before and after dental care of SS patients...
March 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29699604/hindsiipropane-b-alleviates-hiv-1-tat-induced-inflammatory-responses-by-suppressing-hdac6-nadph-oxidase-ros-axis-in-astrocytes
#12
Hyundong Jo, Ha Young Jang, Gi Soo Youn, Donggyu Kim, Chae Yeon Lee, Jae Hee Jang, Soo Young Choi, Jong-Gab Jun, Jinseu Park
Human immunodeficiency virus-1 (HIV-1) transactivator of transcription (Tat) is an important viral factor in neuro-inflammation. Hindsiipropane B, present in Celastrus hindsii, possesses various biological mechanisms including anti-inflammatory activity. In this report, we explored the regulatory activity of hindsiipropane B on HIV-1 Tat-mediated chemokine production and its mode of action in astrocytes. Hindsiipropane B significantly alleviated HIV-1 Tat-mediated production of inflammatory chemokines, CCL2, CXCL8, and CXCL10...
April 27, 2018: BMB Reports
https://www.readbyqxmd.com/read/29696136/typical-kawasaki-disease-presenting-with-pancreatitis-and-bilateral-parotid-gland-involvement-a-case-report-and-literature-review
#13
Matteo Botti, Giorgio Costagliola, Rita Consolini
We describe the case of a 3-year child in which pancreatic and parotid gland involvement preceded the development of the classical clinical phenotype of a typical Kawasaki disease (KD). The child was referred to the Emergency Department with a story of 3 days of continuous fever associated with abdominal pain and bilaterally swelling in the parotid regions; laboratory evaluation identified markedly increased levels of total amylase, pancreatic amylase, lipase, and transaminase, and diagnosis of pancreatitis was posed...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29693127/association-between-gastrointestinal-motility-and-macrophage-mast-cell-distribution-in-mice-during-the-healing-stage-after-dss%C3%A2-induced-colitis
#14
Mio Kodani, Hirokazu Fukui, Toshihiko Tomita, Tadayuki Oshima, Jiro Watari, Hiroto Miwa
Irritable bowel syndrome (IBS) frequently occurs after infectious colitis or inflammatory bowel disease in patients with complete remission. This suggests that post‑inflammation‑associated factors may serve a role in the pathophysiology of IBS; however, the mechanism responsible remains unclear. In the present study, the involvement of macrophages and mast cells in alteration of gastrointestinal (GI) motility was investigated in mice in the remission stage after acute colitis. C57BL/6 mice were administered 2% dextran sulfate sodium in drinking water for 5 days and their intestinal tissues were investigated at intervals for up to 24 weeks...
April 24, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29674655/reduced-oxidative-capacity-in-macrophages-results-in-systemic-insulin-resistance
#15
Saet-Byel Jung, Min Jeong Choi, Dongryeol Ryu, Hyon-Seung Yi, Seong Eun Lee, Joon Young Chang, Hyo Kyun Chung, Yong Kyung Kim, Seul Gi Kang, Ju Hee Lee, Koon Soon Kim, Hyun Jin Kim, Cuk-Seong Kim, Chul-Ho Lee, Robert W Williams, Hail Kim, Heung Kyu Lee, Johan Auwerx, Minho Shong
Oxidative functions of adipose tissue macrophages control the polarization of M1-like and M2-like phenotypes, but whether reduced macrophage oxidative function causes systemic insulin resistance in vivo is not clear. Here, we show that mice with reduced mitochondrial oxidative phosphorylation (OxPhos) due to myeloid-specific deletion of CR6-interacting factor 1 (Crif1), an essential mitoribosomal factor involved in biogenesis of OxPhos subunits, have M1-like polarization of macrophages and systemic insulin resistance with adipose inflammation...
April 19, 2018: Nature Communications
https://www.readbyqxmd.com/read/29669023/the-relevance-of-vitamin-and-iron-deficiency-in-patients-with-inflammatory-bowel-diseases-in-patients-of-the-swiss-ibd-cohort
#16
Matiar Madanchi, Stefania Fagagnini, Nicolas Fournier, Luc Biedermann, Jonas Zeitz, Edouard Battegay, Lukas Zimmerli, Stephan R Vavricka, Gerhard Rogler, Michael Scharl
Background andAims: Vitamin and iron deficiencies are common in patients with inflammatory bowel disease (IBD) as a result of chronic intestinal inflammation, increase in demand, or dietary restrictions. Here, we assessed the frequency of complications in relation to deficiency of iron, folate acid, and vitamin B12 in patients enrolled in the nationwide Swiss Inflammatory Bowel Disease Cohort Study (SIBDCS). Methods: A total of 2666 patients were included in the study, 1558 with Crohn's disease (CD) and 1108 with ulcerative colitis (UC)...
April 13, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29656652/oral-health-disparities-among-adolescents-from-urban-and-rural-communities-of-central-chile
#17
Rodrigo A Giacaman, Ivonne P Bustos, Paulina Bazán, Rodrigo J Mariño
PURPOSE: Rural populations may be at increased risk for prevalent oral diseases. The aim of this study was to compare oral health status of adolescents of rural and urban areas from central Chile. METHODS: A representative sample of 552 and 486 adolescents aged 12 and 15 years, respectively, was examined using WHO methods. Adolescents were chosen from schools belonging to urban and rural districts of the region. Caries status was obtained by decayed, missing, filled teeth (DMFT) and significant caries (SiC) indexes...
April 2018: Rural and Remote Health
https://www.readbyqxmd.com/read/29652019/efficacy-of-green-tea-based-mouthwashes-on-dental-plaque-and-gingival-inflammation-a-systematic-review-and-meta-analysis
#18
REVIEW
Ankita Mathur, D Gopalakrishnan, Vini Mehta, S A Rizwan, Sahana Hegde Shetiya, Shreya Bagwe
Objectives: The purpose of this study was to conduct a systematic review and if appropriate a meta-analysis of the efficacy of daily rinsing with green tea-based mouthwashes in terms of plaque index (PI) and/or gingival index (GI) as compared to other mouthwashes in plaque-induced gingivitis patients. Materials and Methods: MEDLINE, Cochrane Central Register of Controlled Trials, IndMed, Google Scholar, and major journals were searched for studies up to December 2016...
March 2018: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/29651421/when-the-nose-doesn-t-know-canine-olfactory-function-associated-with-health-management-and-potential-links-to-microbiota
#19
REVIEW
Eileen K Jenkins, Mallory T DeChant, Erin B Perry
The impact of health, management, and microbiota on olfactory function in canines has not been examined in review. The most important characteristic of the detection canine is its sense of smell. Olfactory receptors are primarily located on the ethmoturbinates of the nasal cavity. The vomeronasal organ is an additional site of odor detection that detects chemical signals that stimulate behavioral and/or physiological changes. Recent advances in the genetics of olfaction suggest that genetic changes, along with the unique anatomy and airflow of the canine nose, are responsible for the macrosmia of the species...
2018: Frontiers in Veterinary Science
https://www.readbyqxmd.com/read/29649530/self-assembled-hyaluronic-acid-nanoparticles-implications-as-a-nanomedicine-for-treatment-of-type-2-diabetes
#20
Jun Gi Rho, Hwa Seung Han, Ji Hye Han, Hansang Lee, Van Quy Nguyen, Wang Hee Lee, Seunglee Kwon, Sungeun Heo, Juhwan Yoon, Han Ho Shin, Eun-Young Lee, Hoin Kang, Siyoung Yang, Eun Kyung Lee, Jae Hyung Park, Wook Kim
Self-assembled hyaluronic acid nanoparticles (HA-NPs) have been extensively investigated for biomedical and pharmaceutical applications owing to their biocompatibility and receptor-binding properties. Here, we report that an empty HA-NP itself not bearing any drug has therapeutic effects on adipose tissue inflammation and insulin resistance. HA-NPs inhibited not only the receptor-mediated internalization of low-molecular-weight (LMW) free HA but also LMW free HA-induced pro-inflammatory gene expression in mouse primary bone marrow-derived macrophages (BMDMs) isolated from wild-type mice, but not in CD44-null (CD44-/-) BMDMs...
April 9, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
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