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Yazid Belkacemi, Laurianne Colson-Durand, Adeline Granzotto, Shan Husheng, Nhu Hanh To, Soufya Majdoul, Saada Guet, Marie-Laure Hervé, Gloria Fonteneau, Christian Diana, Cindy Le Bret, Claude Dominique, Maryse Fayolle, Nicolas Foray
PURPOSE: After radiation therapy (RT), various radiation-induced toxicities can develop in about one-fourth of patients. An international interest in using morbidity and mortality rates to monitor the quality of care and integrate morbidity and mortality review (MMR) meetings into organizations' governance processes has arisen. We report the first results of patients included in our MMR procedure that included biological assays for individual intrinsic radiosensitivity (IIRS). METHODS AND MATERIALS: Twenty-three patients were prospectively included in the MMR database...
November 1, 2016: International Journal of Radiation Oncology, Biology, Physics
Anna Boladeras, Evelyn Martinez, Ferran Ferrer, Cristina Gutierrez, Salvador Villa, Joan Pera, Ferran Guedea
AIMS AND BACKGROUND: To present survival and toxicity outcomes in patients with clinically localized, non-metastatic prostate cancer (PCa) treated with external beam radiotherapy (EBRT) combined with androgen deprivation therapy (ADT). MATERIALS AND METHODS: Retrospective study of 849 PCa patients (pts) treated from 1996 to 2005. Until August 2000, all patients (281) were treated with conventional dose EBRT (<76 Gy); subsequent pts received ≥76 Gy (565 pts)...
May 2016: Reports of Practical Oncology and Radiotherapy
Yu Zhang, Ping-Wu Zhao, Gang Feng, Gang Xie, An-Qun Wang, Yong-Hong Yang, Dong Wang, Xiao-Bo Du
The aims of this study were to simultaneously evaluate the expression of Y-box binding protein-1 (YB-1) in non-neoplastic rectal tissue and rectal cancer tissue, and to collect clinical follow-up data for individual patients. Additionally, we aimed to investigate the developmental functions and prognostic value of YB-1 in rectal cancer. We performed immunohistochemical studies to examine YB-1 expression in tissue samples from 80 patients with rectal cancer, 30 patients with rectal tubular adenoma, and 30 patients with rectitis...
2015: PloS One
Neşe Kiremit-Korkut, Cağatay Korkut, Hatice Bilge
BACKGROUND: Radiation rectitis is a major problem associated with high-doseirradiation used for pelvic malignancies. OBJECTIVE: The aim of this study was to investigate the possible protectiveeffect of mesalamine against irradiation-induced oxidative tissue damage in an experimental model. METHODS: THREE GROUPS OF FEMALE SPRAGUE DAWLEY RATS WERE ASSIGNED TO RECEIVE TREATMENT AS FOLLOWS: mesalamine enema (60 mg/mL) BID + irradiation (IR) was given to the mesalamine + IR group, and isotonic saline enema BID + irradiation to the control group...
September 2004: Current Therapeutic Research, Clinical and Experimental
Hajime Ushigome, Tetsushi Hayakawa, Mamoru Morimoto, Hidehiko Kitagami, Moritsugu Tanaka
We report a very rare case of rectal arteriovenous fistula following sigmoidectomy and discuss this case in the context of the existing literature. In April 2011, the patient, a man in his 60s, underwent laparoscopic sigmoidectomy with lymph node dissection for sigmoid colon cancer. Beginning in February 2012, he experienced frequent diarrhea. Abdominal contrast-enhanced CT revealed local thickening of the rectal wall and rectal arteriovenous fistula near the anastomosis site. Rectitis from the rectal arteriovenous fistula was diagnosed...
January 2014: Asian Journal of Endoscopic Surgery
Airton Mota Moreira, Carlos Frederico Sparapan Marques, Alberto Azoubel Antunes, Caio Sergio Rizkallah Nahas, Sérgio Carlos Nahas, Miguel Angel de Gregorio Ariza, Francisco Cesar Carnevale
Prostatic artery embolization (PAE) is an alternative treatment for benign prostatic hyperplasia. Complications are primarily related to non-target embolization. We report a case of ischemic rectitis in a 76-year-old man with significant lower urinary tract symptoms due to benign prostatic hyperplasia, probably related to nontarget embolization. Magnetic resonance imaging revealed an 85.5-g prostate and urodynamic studies confirmed Inferior vesical obstruction. PAE was performed bilaterally. During the first 3 days of follow-up, a small amount of blood mixed in the stool was observed...
December 2013: Cardiovascular and Interventional Radiology
Jian-Hong Fu, Zhan Gao, Chen-Chen Ren, Yong-Gang Shi
A total of 285 patients with stage Ib2 and IIa2 cervical cancer were categorized into three groups, and received preoperative neoadjuvant chemotherapy combined with vaginal intracavitary irradiation, neoadjuvant chemotherapy alone or radiotherapy, respectively. The effective rate of 70.6 % in group 1 was much higher than 41.4% in group 2 (P=0.000) and 46.9 % in group 3 (P=0.000); The percentage of patients receiving postoperative adjuvant therapy was 44.1% in group 1, much lower than 67.8% in group 2 (P=0.001) and 64...
2013: Asian Pacific Journal of Cancer Prevention: APJCP
(no author information available yet)
The aim was to evaluate the effectiveness of various fractionation proton boost in the proton-photon radiation therapy of locally advanced prostate. The study included 272 patients with prostate cancer and high-intermediate risk of progression. 114 patients received 3-D conformal local irradiation of the prostate by proton beam 220Mev. The focal dose of 28-28,8 SoGy-eq was fed to the prostate for 8, 5 or 3 fractions for 3, 4 or 5.5 Gy-eq respectively. Given the photon component (44 Gy in 22 fractions to the whole volume of the pelvis), the dose to the prostate was 72...
2012: Voprosy Onkologii
J Egea Valenzuela, F Alberca de las Parras, F Carballo Álvarez, J Molina Martínez
No abstract text is available yet for this article.
February 2011: Revista Española de Enfermedades Digestivas
Na Wang, Quan-Lin Guan, Kai Wang, Xin Zhou, Chen Gao, Han-Teng Yang, Tian-Gen Ni
OBJECTIVE: The objectives of this review are to compare the effectiveness and safety of radiochemotherapy (RTCT) with radiotherapy (RT) alone in locally advanced cervical cancer (LACC). DATA SOURCES: We comprehensively searched the Cochrane library, Medline, EMBASE, Chinese biomedicine literature database, Chinese scientific full-text database and Chinese journal full-text database for relevant articles. The computer search was supplemented with a manual search of reference lists for all available review articles...
January 2011: Archives of Gynecology and Obstetrics
M-P Massoure, P Sockeel, M Richecoeur, A-S Lipovac, J-A Bronstein
We report a 38-year-old immunocompetent patient who presented with a neutropenic rectitis after a treatment by amoxicillin for nasopharyngitis. Neutropenic colitis is a digestive wall inflammation, preferentially localized in the ileo-caecal area and the right colon, which leads to necrosis and sepsis, and usually occurs in neutropenic patients treated by chemotherapy with an incidence of 6%. It is a serious and often lethal disease. The treatment is supportive, and surgery is limited to the occurrence of complications (perforation, bleeding)...
December 2009: La Revue de Médecine Interne
J M Pelgrom, D Vogelaers, I Colle
Five Human Immunodeficiency Virus (HIV) seropositive homosexually active men experienced hepatitis C-seroconversion in the period between September 2004 and January 2007 at a single HIV Reference Center (University Hospital Ghent, Belgium). There was no history of intravenous drug use. All had unprotected anal sex with multiple other HIV seropositive men in the recent past. All of them had clinical syphilis and/or lymphogranuloma venereum rectitis within three to six months before the hepatitis C-seroconversion was detected...
September 2008: Acta Clinica Belgica
M Untereiner, S Renard-Oldrini, H Mecellem, D Burie, Y Lassen, R Ruchaud Phy, S Joseph Phy, L Harzee Phy
Exclusive radiotherapy is one of therapeutic standard in the curative treatment of localized prostate cancer. Results are equivalent when compared with other treatment regimens (radical prostatectomy or curietherapy) in localized forms. However, the patients risks profiles to predict noxious effects are different. Between 2005 and 2006, 27 patients have been treated with intensity modulated radiation therapy and image-guided radiotherapy (IGRT), after implantation of gold markers to target prostate localization during daily radiotherapy seances...
2008: Bulletin de la Société des Sciences Médicales du Grand-Duché de Luxembourg
Vincent de Parades, Pierre Bauer, Philippe Marteau, Laurent Chauveinc, Thierry Bouillet, Patrick Atienza
No abstract text is available yet for this article.
November 2007: Gastroentérologie Clinique et Biologique
Ping Bai, Rong Zhang, Xiao-Guang Li, Shao-Kang Ma, Ling-Ying Wu, Wen-Hua Zhang
OBJECTIVE: To investigate the efficiency of concurrent radiotherapy and chemotherapy for advanced cervical cancer. METHODS: Between Dec. 1999 and Dec. 2003, 158 women with cervical cancer were treated with concurrent radiotherapy and chemotherapy. The regimen was 45 Gy/25 fraction radiation to the pelvis, intracavitary after-loading 7-9 fractions, (42 +/- 7) Gy to point A and 10-30 Gy to cervical submucosa 0.5 cm for debulking; meanwhile, chemotherapy was given with cisplatin 60 mg/m2, d1-d4, and 5-Fu 2400 mg/m2, over a 96-hour period...
June 2007: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
D Peiffert, J-M Simon, F Eschwege
The accident of radiation oncology at the Public General Hospital in Epinal, Vosges, is the highest in France. It is classified level 6 on a 10 degrees scale of the ASN/SFRO (Autorité de sûreté nucléaire/Société française de radiothérapie oncologique). It is linked to errors in the process of treatment, and a mistake in the use of dynamic wedges, with an overdosage of 20%. The clinical consequences are severe, for the patients treated for a prostate cancer and exposed to this overdosage, between May 2005 and August 2006...
November 2007: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Gérard Thiéfin, Laurent Beaugerie
The gastrointestinal toxicity of conventional nonsteroidal antiinflammatory drugs (NSAIDs) is not confined to the stomach and proximal duodenum but extends also to the rest of the small bowel, colon, and rectum. Long-term NSAID therapy usually induces clinically silent enteropathy characterized by increased intestinal permeability and inflammation. Chronic occult bleeding and protein loss may result in iron-deficiency anemia and hypoalbuminemia. NSAIDs can also induce small bowel ulcers that infrequently lead to acute bleeding, perforation, or chronic scarring responsible for diaphragm-like strictures...
July 2005: Joint, Bone, Spine: Revue du Rhumatisme
F Aguiló Lucía, J F Suárez Novo, R Correa Generoso, A Ma Boladeras Inglada, A Polo Rubio, J Pera Fábregas, E Condom Mundo, C Cinos Cope, F Guedea Edo, V Navarro Pérez, N Serrallach Mila
INTRODUCTION: The prostate brachytherapy with I 125 seeds has an indication in patients with organconfined prostate cancer. Our objective is to describe the population treated in our institution with permanent I125 seeds implants, the dosimetric characteristics of the technique and the preliminary results of our group-study in terms of evolution and toxicity. MATERIAL AND METHODS: Between May 2000 and March 2003, 130 patients with permanent implants of I125 seeds were treated...
January 2005: Actas Urologicas Españolas
Cyril Laporte, Anne Larrouy, Martin Housset
For the last 10 years, along with surgery, radiotherapy has become a major issue in the curative treatment of prostate cancer. Several radiotherapy techniques can be used. In good prognosis cancers, when the prostate is small, brachytherapy is one of the therapeutic options. By implanting radioactive seeds within the prostate, this technique permits strictly limited intraprostatic irradiation. Conformal external beam (3D) radiotherapy adapts to individual morphology according to dosimetric CT scan data. This is particularly useful to deliver a high dose in the target volume while limiting the dose in surrounding organs...
December 31, 2003: La Revue du Praticien
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