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https://www.readbyqxmd.com/read/28628467/juvenile-and-adult-onset-systemic-lupus-erythematosus-a-comparative-study-in-a-large-cohort-from-the-spanish-society-of-rheumatology-lupus-registry-relesser
#1
Vicenç Torrente-Segarra, Tarek Carlos Salman Monte, Iñigo Rúa-Figueroa, Fernando Sánchez-Alonso, Francisco Javier López-Longo, María Galindo-Izquierdo, Jaime Calvo-Alén, Alejandro Olivé-Marqués, Jesús Ibañez-Ruán, Loreto Horcada, Ana Sánchez-Atrio, Carlos Montilla, Rafael Benito Melero González, Elvira Díez-Álvarez, Victor Martinez-Taboada, José Luis Andreu, Olaia Fernández-Berrizbeitia, José Ángel Hernández-Beriain, Marian Gantes, Blanca Hernández-Cruz, Ángela Pecondón-Español, Carlos Marras, Gema Bonilla, José M Pego-Reigosa
OBJECTIVES: We aimed to describe juvenile-onset systemic lupus erythematosus (jSLE) features and to establish its differences compared to adult-onset SLE (aSLE) from a large national database. METHODS: Data from patients (≥4 ACR criteria) included in Spanish Society of Rheumatology Lupus Registry (RELESSER) were analysed. Sociodemographic, clinical, serological, activity, treatment, cumulative damage, comorbidities and severity data were collected. Patients with disease onset <18 years were described and compared to those with disease onset ≥18 years...
June 12, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28627154/-mortality-study-in-a-cohort-of-workers-employed-in-the-hot-working-processing-of-plastics-and-rubber
#2
Alberto Gerosa, Corrado Scarnato, Bruno Marchesini, Evi Ietri, Venere Leda Mara Pavone
OBJECTIVES: to study mortality rates among workers in companies manufacturing thermoplastic and rubber articles (excluding tyres). DESIGN: cohort study. SETTING AND PARTICIPANTS: the cohort includes 4,543 workers employed up to 2000 in 131 companies in the Province of Bologna (Emilia-Romagna Region, Northern Italy) exposed to emissions from hot processing of plastics (3,937) and rubber (606). MAIN OUTCOME MEASURES: general- and cause-specific Standardized Mortality Rates (SMR), with 95% confidence intervals; entire reference population resides in the Emilia-Romagna Region...
January 2017: Epidemiologia e Prevenzione
https://www.readbyqxmd.com/read/28618093/influence-of-gender-bmi-and-body-shape-on-theoretical-injection-outcome-at-the-ventrogluteal-and-dorsogluteal-sites
#3
Theresa A Larkin, Elfriede Ashcroft, Blake A Hickey, Asmahan Elgellaie
AIMS AND OBJECTIVES: This study aimed to determine the influences of gender, BMI and observed body shape (OBS) on subcutaneous fat and muscle thicknesses, and theoretical injection outcome, at the ventrogluteal and dorsogluteal intramuscular injection sites. BACKGROUND: Debate continues as to whether the dorsogluteal or ventrogluteal injection site is more reliable for a successful intramuscular injection outcome. Subcutaneous fat and muscle thicknesses at the injection site are direct determinants of intramuscular injection outcome...
June 15, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28611598/early-paradoxical-increase-of-dopamine-a-neurochemical-study-of-olfactory-bulb-in-asymptomatic-and-symptomatic-mptp-treated-monkeys
#4
Christian Pifl, Harald Reither, Natalia Lopez-Gonzalez Del Rey, Carmen Cavada, Jose A Obeso, Javier Blesa
Parkinson's disease (PD) is a neurodegenerative disease with both motor and non-motor manifestations. Hyposmia is one of the early non-motor symptoms, which can precede motor symptoms by several years. The relationship between hyposmia and PD remains elusive. Olfactory bulb (OB) pathology shows an increased number of olfactory dopaminergic cells, protein aggregates and dysfunction of neurotransmitter systems. In this study we examined tissue levels of dopamine (DA) and serotonin (5-hydroxytryptamine, 5-HT) and their metabolites, of noradrenaline (NA) and of the amino acid neurotransmitters aspartate, glutamate, taurine and γ-aminobutyric acid in OBs of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treated Macaca fascicularis in different stages, including monkeys who were always asymptomatic, monkeys who recovered from mild parkinsonian signs, and monkeys with stable moderate or severe parkinsonism...
2017: Frontiers in Neuroanatomy
https://www.readbyqxmd.com/read/28610389/a-new-indian-record-and-morphological-variation-for-eulimnadia-khoratensis-rogers-et-al-2016-crustacea-branchiopoda-spinicaudata
#5
Sameer M Padhye, Mihir R Kulkarni
Eulimnadia Packard, 1874 is the most species rich and widely distributed genus within the Limnadiidae (Reed et al. 2015). Species identification relies primarily on egg morphology as adult morphological characters show high variability, sometimes within the same populations and hence of little use (Rabet, 2010; Rogers et al. 2012). Seven species are currently known from the Indian subcontinent (sensu Rogers & Padhye 2015) and SE Asia (Rogers et al. 2016). Of these, four species, viz. E. compressa (Baird, 1860), E...
May 15, 2017: Zootaxa
https://www.readbyqxmd.com/read/28596505/progressive-modulation-of-the-human-olfactory-bulb-transcriptome-during-alzheimer%C3%A2-s-disease-evolution-novel-insights-into-the-olfactory-signaling-across-proteinopathies
#6
Mercedes Lachen-Montes, María Victoria Zelaya, Víctor Segura, Joaquín Fernández-Irigoyen, Enrique Santamaría
Alzheimer´s disease (AD) is characterized by progressive dementia, initially presenting olfactory dysfunction. Despite the olfactory bulb (OB) is the first central structure of the olfactory pathway, we lack a complete molecular characterization of the transcriptional events that occurs in this olfactory area during AD progression. To address this gap in knowledge, we have assessed the genome-wide expression in postmortem OBs from subjects with varying degree of AD pathology. A stage-dependent deregulation of specific pathways was observed, revealing transmembrane transport, and neuroinflammation as part of the functional modules that are disrupted across AD grading...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28596462/-pure-amnesia
#7
Koichi Tagawa, Haruki Tokida
Pure amnesia (amnesic syndrome) is an organic brain syndrome characterized by impairment in episodic memory, with either an anterograde or sometimes retrograde loss of memories. Although episodic memory is impaired, semantic memory, immediate memory, and procedural memory are preserved. The Papez circuit is a network of nerve fibers and nerve centers that starts and ends in the hippocampus travelling by way of the fornix, mammillary bodies, anterior thalamic nuclei, cingulate gyrus, and parahippocampal gyrus...
June 2017: Brain and Nerve, Shinkei Kenkyū No Shinpo
https://www.readbyqxmd.com/read/28589860/gaussiancpg-a-gaussian-model-for-detection-of-cpg-island-in-human-genome-sequences
#8
Ning Yu, Xuan Guo, Alexander Zelikovsky, Yi Pan
BACKGROUND: As crucial markers in identifying biological elements and processes in mammalian genomes, CpG islands (CGI) play important roles in DNA methylation, gene regulation, epigenetic inheritance, gene mutation, chromosome inactivation and nuclesome retention. The generally accepted criteria of CGI rely on: (a) %G+C content is ≥ 50%, (b) the ratio of the observed CpG content and the expected CpG content is ≥ 0.6, and (c) the general length of CGI is greater than 200 nucleotides...
May 24, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28588750/image-quality-and-diagnostic-performance-of-free-breathing-diffusion-weighted-imaging-for-hepatocellular-carcinoma
#9
Yukihisa Takayama, Akihiro Nishie, Yoshiki Asayama, Kousei Ishigami, Daisuke Kakihara, Yasuhiro Ushijima, Nobuhiro Fujita, Ken Shirabe, Atsushi Takemura, Hiroshi Honda
AIM: To retrospectively evaluate the diagnostic performance of free-breathing diffusion-weighted imaging (FB-DWI) with modified imaging parameter settings for detecting hepatocellular carcinomas (HCCs). METHODS: Fifty-one patients at risk for HCC were scanned with both FB-DWI and respiratory-triggered DWI with the navigator echo respiratory-triggering technique (RT-DWI). Qualitatively, the sharpness of the liver contour, the image noise and the chemical shift artifacts on each DWI with b-values of 1000 s/mm(2) were independently evaluated by three radiologists using 4-point scoring...
May 18, 2017: World Journal of Hepatology
https://www.readbyqxmd.com/read/28570047/scaling-proteome-wide-reactions-of-activity-based-probes
#10
Song Li, Pamela A Diego-Limpin, Bekim Bajrami, Santosh Keshipeddy, Ying-Wai Lam, Bin Deng, Vahid Farrokhi, Adam J McShane, Reza Nemati, Amy R Howell, Xudong Yao
Unified analysis of complex reactions of an activity-based probe with proteins in a proteome remains an unsolved challenge. We propose a power expression, rate = k(obs)[Probe](α), for scaling the progress of proteome-wide reactions and use the scaling factor (0 ≤ α ≤ 1) as an apparent, partial order with respect to the probe to measure the "enzyme-likeness" for a protein in reaction acceleration. Thus, α reports the intrinsic reactivity of the protein with the probe. When α = 0, the involved protein expedites the reaction to the maximal degree; when α = 1, the protein reacts with the probe via an unaccelerated, bimolecular reaction...
June 5, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28567321/neuropsychiatric-manifestations-in-a-patient-with-panhypopituitarism
#11
Oluwole Jegede, Ajouka Jeyakumar, Thyarapan Balakumar, Alyssa Raghu, Katherine I Chang, Katarina Soewono, Mario Gustave, Ayodeji Jolayemi
We present a case of an incidental diagnosis of panhypopituitarism in a 68-year-old African American man admitted to our psychiatric inpatient unit with symptoms suggestive of schizophrenia. The case was unusual as a first-episode psychosis given the patient's age. In the course of his admission, the patient's clinical condition deteriorated culminating in a sudden altered mental status which prompted a transfer to the medical floors and further investigations. A head CT scan and a pituitary MRI revealed a near total resection of the pituitary while laboratory investigations revealed hyponatremia and a grossly low hormone profile...
2017: Case Reports in Psychiatry
https://www.readbyqxmd.com/read/28550792/social-stress-contagion-in-rats-behavioural-autonomic-and-neuroendocrine-correlates
#12
Luca Carnevali, Nicola Montano, Rosario Statello, Gino Coudé, Federica Vacondio, Silvia Rivara, Pier Francesco Ferrari, Andrea Sgoifo
The negative emotional consequences associated with life stress exposure in an individual can affect the emotional state of social partners. In this study, we describe an experimental rat model of social stress contagion and its effects on social behaviour and cardiac autonomic and neuroendocrine functions. Adult male Wistar rats were pair-housed and one animal (designated as "demonstrator" (DEM)) was submitted to either social defeat stress (STR) by an aggressive male Wild-type rat in a separate room or just exposed to an unfamiliar empty cage (control condition, CTR), once a day for 4 consecutive days...
May 20, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28543873/effect-of-surgery-vs-observation-skeletal-5-year-outcomes-in-a-randomized-trial-of-patients-with-primary-hpt-the-siph-study
#13
Karolina Lundstam, Ansgar Heck, Kristin Godang, Charlotte Mollerup, Marek Baranowski, Ylva Pernow, Turid Aas, Ola Hessman, Thord Rosén, Jörgen Nordenström, Svante Jansson, Mikael Hellström, Jens Bollerslev
Mild primary hyperparathyroidism (PHPT) is known to affect the skeleton, even though patients usually are asymptomatic. Treatment strategies have been widely discussed. However, long-term randomized studies comparing parathyroidectomy to observation are lacking. The objective was to study the effect of parathyroidectomy (PTX) compared to observation (OBS) on bone mineral density (BMD) in g/cm(2) and T-scores, and on biochemical markers of bone turnover (P1NP and CTX-1), in a prospective randomized controlled study of patients with mild PHPT after 5 years of follow-up...
May 25, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28541639/opportunistic-bilateral-salpingectomy-during-benign-gynecological-surgery-for-ovarian-cancer-prevention-a-survey-of-gynecologic-oncology-committee-of-japan-society-of-obstetrics-and-gynecology
#14
Mikio Mikami, Satoru Nagase, Wataru Yamagami, Kimio Ushijma, Hironori Tashiro, Hidetaka Katabuchi
OBJECTIVE: Recent evidence has supported the concept that epithelial ovarian cancer (EOC) arises from the cells of the fallopian tube or endometrium. This study investigated current practice in Japan with respect to performing opportunistic bilateral salpingectomy (OBS) during gynecological surgery for benign disease for Ovarian Cancer Prevention. METHODS: We mailed a questionnaire to 767 hospitals and clinics, comprising 628 accredited training institutions of the Japan Society of Obstetrics and Gynecology (JSOG), Japan Society of Gynecologic Oncology (JSGO), or Japan Society of Gynecologic and Obstetric Endoscopy and Minimally Invasive Therapy (JSGOE) and 139 private institutions with at least one JSGOE-certified licensed gynecologic laparoscopist...
July 2017: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/28536324/-human-mesenchymal-stromal-stem-cell-as-a-source-of-cell-therapy-and-a-pharmacological-target-for-disease-treatment
#15
Yasuo Miura
Human mesenchymal stromal/stem cells(MSCs)show a multiple biological characteristics including the immunomodulation, tissue regeneration and hematopoiesis-supportive capability. Cell therapy by the use of MSCs has been extensively explored for a variety of diseases. Several tissues/organs are clinically available for a source of MSCs, and isolated cells are culture-expanded and subsequently injected into patients systemically or locally. MSCs organize the tissue/organ environment they reside, and in bone/marrow, MSCs differentiate into osteoblasts(OBs)that contribute to bone remodeling...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28534659/healthcare-costs-among-men-with-favorable-risk-prostate-cancer-managed-with-observation-strategies-versus-immediate-treatment-in-an-integrated-healthcare-system
#16
Furaha Kariburyo, Yuexi Wang, I-Ning Elaine Cheng, Lisa Wang, David Morgenstern, Igor Asner, Lin Xie, Eric Meadows, John Danella
OBJECTIVE: This study explored short-term healthcare costs of men managed with observation strategies (OBS) vs immediate treatment (IMT) for favorable risk prostate cancer (PCa) from the Geisinger Health System, a single integrated health system in Pennsylvania, as evidence from the community setting is limited. METHODS: A retrospective cohort study was conducted using electronic health records from men aged ≥40 years diagnosed with favorable risk PCa (T1 or 2, PSA ≤15 ng/mL, Gleason ≤7 [3 + 4]) between January 2005 and October 2013...
June 8, 2017: Journal of Medical Economics
https://www.readbyqxmd.com/read/28532322/the-overt-behaviour-scale-self-report-obs-sr-for-acquired-brain-injury-exploratory-analysis-of-reliability-and-validity
#17
Glenn Kelly, Grahame K Simpson, Suzanne Brown, Peter Kremer, Lauren Gillett
The objectives were to test the properties, via a psychometric study, of the Overt Behaviour Scale-Self-Report (OBS-SR), a version of the OBS-Adult Scale developed to provide a client perspective on challenging behaviours after acquired brain injury. Study sample 1 consisted of 37 patients with primary brain tumour (PBT) and a family-member informant. Sample 2 consisted of 34 clients with other acquired brain injury (mixed brain injury, MBI) and a service-provider informant. Participants completed the OBS-SR (at two time points), and the Awareness Questionnaire (AQ) and Mayo Portland Adaptability Inventory-III (MPAI-III) once; informants completed the OBS-Adult and AQ once only...
May 23, 2017: Neuropsychological Rehabilitation
https://www.readbyqxmd.com/read/28522862/expression-profiling-of-mrnas-and-long-non-coding-rnas-in-aged-mouse-olfactory-bulb
#18
Ming Wang, Wei Liu, Jian Jiao, Jingyun Li, Chengshuo Wang, Luo Zhang
Age-related decline in olfactory function affects the quality of life in elderly people and also potentially represents an early clinical symptom of neurodegenerative disorder. Olfactory bulb (OB) plays a central role in olfactory information transmitting and signal processing. The mechanisms underlying this impairment remain unclear. In the current study, microarray was used to investigate differentially expressed protein coding genes (PCGs) and long non-coding RNAs (lncRNAs) in OBs from three groups of mice of different ages (2 months-old young adults, 6 months-old mature adults and 20 months-old aged adults), for their potential roles in olfactory impairment...
May 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28500509/observations-of-termitarium-geophagy-by-rylands-bald-faced-saki-monkeys-pithecia-rylandsi-in-madre-de-dios-peru
#19
Dara B Adams, Jennifer A Rehg, Mrinalini Watsa
Geophagy, or soil consumption, has been documented in diverse animal taxa, including many primates. Physiological functions such as mineral supplementation, detoxification of secondary compounds, and antacid properties are possible causes for this behavior. We report on observations of geophagy at arboreal termitaria by free-ranging Pithecia rylandsi at La Estación Biológica Los Amigos (EBLA) in Perú between 2008 and 2015. Characteristics of geophagy events, including saki monkey behavior at the termitaria, were recorded and geochemical analyses were conducted on consumed termitaria, nearby topsoils, and unvisited termitaria...
July 2017: Primates; Journal of Primatology
https://www.readbyqxmd.com/read/28500037/improving-baculovirus-infectivity-by-efficiently-embedding-enhancing-factors-into-occlusion-bodies
#20
Shili Yang, Lijuan Zhao, Ruipeng Ma, Wei Fang, Jia Hu, Chengfeng Lei, Xiulian Sun
The relatively low infectivity of baculoviruses to their host larvae limits their use as insecticidal agents on a larger scale. Here, a novel strategy was developed to efficiently embed foreign proteins into Autographa californica multiple nucleopolyhedrovirus (AcMNPV) occlusion bodies (OBs) to achieve stable expression of foreign proteins and improve viral infectivity. A recombinant AcMNPV bacmid was constructed by expressing the 150 amino acid (aa) N-terminal segment of the polyhedrin under the control of the p10 promoter and the remaining C-terminal 95-aa segment under the control of the polyhedrin promoter...
May 12, 2017: Applied and Environmental Microbiology
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