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https://www.readbyqxmd.com/read/28441794/reciprocal-interactions-of-leukemic-cells-with-bone-marrow-stromal-cells-promote-enrichment-of-leukemic-stell-cell-compartments-in-response-to-curcumin-and-daunorubicin
#1
Saeed Mohammadi, Mohsen Nikbakht, Seyed Mehdi Sajjadi, Fariba Rad, Bahram Chahardouli, Javid Sabour Takanlu, Shahrbano Rostami, Kamran Alimoghaddam, Ardeshir Ghavamzadeh, Seyed H Ghaffari
A predominant challenge in developing curative leukemia therapy is interactions of leukemic cells with the bone marrow stromal microenvironment. We aimed to investigate the role of stromal cells, such as bone marrow mesenchymal stromal cells (BMSCs) and osteoblasts (OBs), in curcumin (CUR) and daunorubicin (DNR) induced apoptosis of acute myeloid leukemia (AML) cells. We used KG1 and U937 as leukemia cell line models and treated them with CUR and DNR. The cells were then co-cultured with BMSCs or a combination of BMSCs and OBs as feeders...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28424279/phosphorylation-induces-structural-changes-in-the-autographa-californica-nucleopolyhedrovirus-p10-protein
#2
Farheen Raza, Joanna F McGouran, Benedikt M Kessler, Robert D Possee, Linda A King
Baculoviruses encode a variety of auxiliary proteins that are not essential for viral replication but provide them with a selective advantage in nature. P10 is a 10 kDa auxiliary protein produced in the very-late phase of gene transcription by Autographa californica multiple nucleopolyhedrovirus (AcMNPV). The P10 protein forms cytoskeletal-like structures in the host cell that associate with microtubules varying from filamentous forms in the cytoplasm to aggregated peri-nuclear tubules that form a cage-like structure around the nucleus...
April 19, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28407060/role-of-osteoblast-gi-signaling-in-age-related-bone-loss-in-female-mice
#3
Susan M Millard, Liping Wang, Lalita Wattanachanya, Dylan O'Carroll, Aaron J Fields, Joyce Pang, Galateia Kazakia, Jeffrey C Lotz, Robert A Nissenson
Age-related bone loss is an important risk factor for fractures in the elderly, resulting from an imbalance in bone remodeling mainly due to decreased bone formation. We have previously demonstrated that endogenous G protein coupled receptor (GPCR)-driven Gi signaling in osteoblasts (Obs) restrains bone formation in mice during growth. Here, we launched a longitudinal study to test the hypothesis that Gi signaling in Obs restrains bone formation in aging mice, thereby promoting bone loss. Our approach was to block Gi signaling in maturing Obs by the induced expression of the catalytic subunit of pertussis toxin (PTX) after the achievement of peak bone mass...
April 12, 2017: Endocrinology
https://www.readbyqxmd.com/read/28384101/novel-therapeutic-approaches-of-natural-oil-from-black-seeds-and-its-underlying-mechanisms-against-kidney-dysfunctions-in-haloperidol-induced-male-rats
#4
Jacob K Akintunde, Opeyemi K Abubakar
BACKGROUND: Antipsychotic drugs could be nephrotoxic in schizophrenia patients. METHODS: The present study investigated the protective effect of oil from black seed on kidney dysfunctions using several biological approaches in adult rats. The animals were divided into six groups (n=10): normal control rats; haloperidol (HAL)-induced rats: induced rats were pre-, co- and post-treated with black seed oil (BSO), respectively, and the last group was treated with the oil only...
April 6, 2017: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/28382973/acidic-ph-environment-induces-autophagy-in-osteoblasts
#5
Zhichao Zhang, Qingguo Lai, Yanan Li, Chao Xu, Xiaopeng Tang, Jiangbo Ci, Shaolong Sun, Bingbing Xu, Yan Li
Osteoblasts (OBs) play an important role in bone fracture healing, yet the extreme adverse microenvironment in fracture sites has a negative impact on the survival of OBs. Therefore, it is important to study how OBs behave in the complex fracture microenvironment. Studies have shown that autophagy plays a pivotal role in maintaining cellular homeostasis and defending the cell against adverse microenvironments. In this study we found the induction of autophagy in OBs at femoral bone fracture sites, which may be a result of ischemia, oxidative stress and hypoxia within the local area...
April 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28362787/dynamics-of-an-optically-bound-structure-made-of-particles-of-unequal-sizes
#6
Vítězslav Karásek, Martin Šiler, Oto Brzobohatý, Pavel Zemánek
This theoretical study based on the coupled dipoles model focuses on the dynamics of two optically bound dielectric spheres of unequal sizes confined in counter-propagating incoherent Bessel beams. We analyzed the relative motion of the particles with respect to each other and defined conditions where they form a stable optically bound structure (OBS). We also investigated the motion of the center of mass of the OBS and found that its direction depends on the particle separation in the structure. Besides the optical interaction between objects, we also considered a hydrodynamic coupling in order to obtain more precise results for moving an OBS...
April 1, 2017: Optics Letters
https://www.readbyqxmd.com/read/28359918/the-effects-of-desipramine-fluoxetine-or-tianeptine-on-changes-in-bulbar-bdnf-levels-induced-by-chronic-social-instability-stress-and-inflammation
#7
Marta M Nowacka-Chmielewska, Daniela Kasprowska, Monika Paul-Samojedny, Anna M Bielecka-Wajdman, Jarosław J Barski, Andrzej Małecki, Ewa Obuchowicz
BACKGROUND: Stress is a major predisposing factor in the development of psychiatric disorders and potential source of augmented inflammatory processes in the brain. Increasing body of evidence shows an important role of alterations in the olfactory bulbs (OBs) function in stress-related disorders. The aim of the present study was to investigate the impact of antidepressants on the alterations of brain-derived neurotrophic factor (BDNF) induced by lipopolysaccharide (LPS) in female rats subjected to chronic social instability stress (CSIS)...
January 17, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28339626/a-ward-based-time-study-of-paper-and-electronic-documentation-for-recording-vital-sign-observations
#8
David Wong, Timothy Bonnici, Julia Knight, Stephen Gerry, James Turton, Peter Watkinson
Objective: To investigate time differences in recording observations and an early warning score using traditional paper charts and a novel e-Obs system in clinical practice. Methods: Researchers observed the process of recording observations and early warning scores across 3 wards in 2 university teaching hospitals immediately before and after introduction of the e-Obs system. The process of recording observations included both measurement and documentation of vital signs...
February 11, 2017: Journal of the American Medical Informatics Association: JAMIA
https://www.readbyqxmd.com/read/28334492/opportunistic-salpingectomy-for-prevention-of-ovarian-cancer
#9
Ranjit Manchanda
Opportunistic Bilateral Salpingectomy (OBS) has been proposed and is now increasingly being undertaken as a strategy to prevent ovarian cancer (OC). Darelius et al present a systematic literature review for impact of salpingectomy on OC-risk, surgical outcomes and endocrine function. The authors highlight and reconfirm the limited and low-quality of available evidence on level of OC-risk reduction and ovarian function (Darelius,BJOG;2017). Two large retrospective studies reporting a 35%-42% OC-risk reduction following salpingectomy, suffer from indication and detection bias...
March 23, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28325258/quality-of-reporting-in-oncology-studies-a-systematic-analysis-of-literature-reviews-and-prospects
#10
REVIEW
Romain Rivoirard, Aurélie Bourmaud, Mathieu Oriol, Fabien Tinquaut, Benoîte Méry, Julien Langrand-Escure, Alexis Vallard, Pierre Fournel, Nicolas Magné, Franck Chauvin
The present review gives an overview of systematic reviews published in peer reviewed Journals analysing quality of reporting in oncology studies. PUBMED and Cochrane library were searched to identify systematic reviews assessing quality of reporting for randomized controlled trials (RCTs) and observational studies (OBS). Recommendations and primary endpoints used to assess the quality of reporting were described. Intrinsic quality of reporting was analyzed using an Overall Quality Score for literature Reviews (OQSR)...
April 2017: Critical Reviews in Oncology/hematology
https://www.readbyqxmd.com/read/28321699/magnetic-edta-functionalized-cofe2o4-nanoparticles-edta-cofe2o4-as-a-novel-catalyst-for-peroxymonosulfate-activation-and-degradation-of-orange-g
#11
Lin Deng, Zhou Shi, Zhiyan Zou, Shiqing Zhou
EDTA functionalized CoFe2O4 nanoparticles (EDTA-CoFe2O4) synthesized using a facile one-pot solvothermal method were employed as catalysts to activate peroxymonosulfate (PMS) with Orange G (OG) as the target pollutant. Effects of operating parameters including initial solution pH, catalyst dosage, PMS dosage, and water matrix components such as Cl(-), NO3(-), CO3(2-), and humic acid were evaluated. A degradation efficiency of 93% was achieved in 15 min with 1 mM PMS and 0.2 g/L EDTA-CoFe2O4 catalyst, while only 57% of OG was degraded within 15 min in CoFe2O4/PMS system...
March 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28285313/oxidative-balance-score-and-the-risk-of-end-stage-renal-disease-and-cardiovascular-disease
#12
Titilayo O Ilori, Xiao Wang, Morong Huang, Orlando M Gutierrez, K M Venkat Narayan, Michael Goodman, William McClellan, Laura Plantinga, Akinlolu O Ojo
BACKGROUND: Oxidative balance score (OBS) is a composite measure of oxidative stress-related exposures. The aim of this study was to investigate the association between OBS, end-stage renal disease (ESRD), and cardiovascular disease (CVD). METHODS: Using data from the Chronic Renal Insufficiency Cohort, we calculated the main exposure OBS by summing up 12 apriori-defined pro- and antioxidant factors obtained from the diet history questionnaire and lifestyle assessment...
2017: American Journal of Nephrology
https://www.readbyqxmd.com/read/28279683/long-term-pulmonary-complications-in-perinatally-hiv-infected-youth
#13
William T Shearer, Denise L Jacobson, Wendy Yu, George K Siberry, Murli Purswani, Suzanne Siminski, Laurie Butler, Erin Leister, Gwendolyn Scott, Russell B Van Dyke, Ram Yogev, Mary E Paul, Ana Puga, Andrew A Colin, Meyer Kattan
BACKGROUND: Increased incidence and prevalence of asthma have been documented for perinatally HIV-infected youth 10 to 21 years of age compared with HIV-exposed uninfected (HEU) youth. OBJECTIVE: We sought to perform objective pulmonary function tests (PFTs) in HIV-infected and HEU youth with and without diagnosed asthma. METHOD: Asthma was determined in 370 participants (218 HIV-infected and 152 HEU participants) by means of chart review and self-report at 13 sites...
March 6, 2017: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/28274194/the-combined-effects-of-nanotopography-and-sr-ion-for-enhanced-osteogenic-activity-of-bone-marrow-mesenchymal-stem-cells-bmscs
#14
Dandan Hu, Kai Li, Youtao Xie, Houhua Pan, Jun Zhao, Liping Huang, Xuebin Zheng
Both surface topography and chemistry have a significant influence on the biological performance of orthopedic implant coatings. In our study, a surface modification strategy embodying bioactive trace element incorporation and nanotopography construction was employed to enhance the osteogenic activity of calcium silicate (Ca-Si) coatings. We developed strontium-loaded nanolayer on plasma sprayed Ca-Si (CS) coating via hydrothermal treatment which was denoted as Sr-NT-CS. The original CS coating and the CS coating modified with similar nanotopography (NT-CS) were studied in parallel...
March 2017: Journal of Biomaterials Applications
https://www.readbyqxmd.com/read/28265352/nutritional-quality-and-sensory-acceptability-of-complementary-food-blended-from-maize-zea-mays-roasted-pea-pisum-sativum-and-malted-barley-hordium-vulgare
#15
Obse Fikiru, Geremew Bultosa, Sirawdink Fikreyesus Forsido, Mathewos Temesgen
The aim of this study was to evaluate the effect of blending ratio of malted barley, maize, and roasted pea flour on complementary food quality and sensory acceptability. D- Optimal mixture design was used to generate 14 formulations. Each ingredient had 55-90% maize, 20-35% pea and 4-12% malted barley. Pretreatments like debranning of maize, roasting of pea and dehusking of malted barley were done. The three component-constrained mixture design was conducted using Design-Expert(®) 6 (Stat-Ease). Ash, protein, fat, fiber, moisture, and carbohydrate contents were found in between range of 1...
March 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28258305/oxidative-balance-score-and-serum-%C3%AE-glutamyltransferase-level-among-korean-adults-a-nationwide-population-based-study
#16
A-Ra Cho, Yu-Jin Kwon, Hyoung-Ji Lim, Hye Sun Lee, Sinae Kim, Jae-Yong Shim, Hye-Ree Lee, Yong-Jae Lee
PURPOSE: The oxidative balance score (OBS) comprises dietary and non-dietary lifestyle pro-oxidants and antioxidants. Elevated serum γ-glutamyltransferase (GGT) level has currently emerged as a biomarker of oxidative stress. In this study, we examined whether OBS was inversely associated with serum GGT level and whether OBS could be a useful marker to predict GGT among Korean adults. METHODS: This cross-sectional study was based on data obtained from the 2010 and 2011 Korea National Health and Nutrition Examination Survey...
March 3, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28245117/octadentate-zirconium-iv-loaded-macrocycles-with-varied-stoichiometry-assembled-from-hydroxamic-acid-monomers-using-metal-templated-synthesis
#17
William Tieu, Tulip Lifa, Andrew Katsifis, Rachel Codd
The reaction between Zr(IV) and the forward endo-hydroxamic acid monomer 4-[(5-aminopentyl)(hydroxy)amino]-4-oxobutanoic acid (for-PBH) in a 1:4 stoichiometry in the presence of diphenylphosphoryl azide and triethylamine gave the octadentate Zr(IV)-loaded tetrameric hydroxamic acid macrocycle for-[Zr(DFOT1)] ([M + H](+) calc 887.3, obs 887.2). In this metal-templated synthesis (MTS) approach, the coordination preferences of Zr(IV) directed the preorganization of four oxygen-rich bidentate for-PBH ligands about the metal ion prior to ring closure under peptide coupling conditions...
February 28, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28240358/an-advanced-tri-culture-model-to-evaluate-the-dynamic-interplay-among-osteoblasts-osteoclasts-and-endothelial-cells
#18
Stefania Pagani, Paola Torricelli, Francesca Veronesi, Francesca Salamanna, Simona Cepollaro, Milena Fini
The dynamic metabolism and the numerous roles of bone tissue necessitate a suitable in vitro model to represent them. In order to investigate the interaction among the several cell types composing bone microenvironment, we studied a tri-culture model including human osteoblasts (OBs), osteoclasts (OCs) and endothelial cells (HUVEC). While OBs are essential for bone deposition and OCs for bone resorption, the vasculature is necessary to provide growth factors, nutrients and oxygen in the mature tissue. The results of this study showed a strong mutual influence between OBs, OCs and HUVEC in term of proliferation, viability and activity (release of ALP, Coll I, OPG, RANKL, VEGF, CTSK, TGFβ and IL-6)...
February 27, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28221866/hormonal-maintenance-therapy-for-women-with-low-grade-serous-cancer-of-the-ovary-or-peritoneum
#19
David M Gershenson, Diane C Bodurka, Robert L Coleman, Karen H Lu, Anais Malpica, Charlotte C Sun
Purpose The purpose of this study was to examine outcomes associated with hormonal maintenance therapy (HMT) compared with routine observation (OBS) after primary cytoreductive surgery and platinum-based chemotherapy in women with stage II to IV low-grade serous carcinoma of the ovary or peritoneum. Patients and Methods Eligibility criteria for patients from our database were: treatment with primary surgery followed by platinum-based chemotherapy, stage II to IV disease, at least 2 years of follow-up for patients who had not experienced recurrence, and adequate clinical information...
April 1, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28210351/cross-continuum-tool-is-associated-with-reduced-utilization-and-cost-for-frequent-high-need-users
#20
Lauran Hardin, Adam Kilian, Leslie Muller, Kevin Callison, Michael Olgren
INTRODUCTION: High-need, high-cost (HNHC) patients can over-use acute care services, a pattern of behavior associated with many poor outcomes that disproportionately contributes to increased U.S. healthcare cost. Our objective was to reduce healthcare cost and improve outcomes by optimizing the system of care. We targeted HNHC patients and identified root causes of frequent healthcare utilization. We developed a cross-continuum intervention process and a succinct tool called a Complex Care Map (CCM)© that addresses fragmentation in the system and links providers to a comprehensive individualized analysis of the patient story and causes for frequent access to health services...
February 2017: Western Journal of Emergency Medicine
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