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Teng Hwee Tan, Yu Yang Soon, Timothy Cheo, Francis Ho, Lea Choung Wong, Jeremy Tey, Ivan W K Tham
PURPOSE: To determine if the addition of induction chemotherapy (IC) to concurrent chemoradiation (CCRT) in locally advanced nasopharyngeal carcinoma (LA-NPC) can improve survival. METHODS: We performed a meta-analysis of both randomized controlled trials (RCTs) and observational studies (OBS) to compare the effects of addition of IC to CCRT versus (vs) CCRT alone on overall survival (OS), progression free survival (PFS), distant metastasis-free survival (DMFS) and adverse events (AE) in LA-NPC...
March 16, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
Mujgan Inozu, Yasemin Kahya, Orcun Yorulmaz
Neuroticism and religiosity are distal vulnerability factors for OCD phenomenon. The present study aimed to examine the roles of obsessive beliefs (OBs), thought-control strategies, and guilt in the relationship between these vulnerability factors and obsessive-compulsive symptoms (OCSs), specifically scrupulosity symptoms in a Muslim sample via SEM. The sample consisted of 273 university students who filled out a set of questionnaires. The results indicated that neuroticism and the degree of religiosity predict OBs that are positively associated with guilt and self-punishment both of which predict scrupulosity and other OCSs...
March 17, 2018: Journal of Religion and Health
Yujiro Matsuishi, Haruhiko Hoshino, Nobutake Shimojo, Yuki Enomoto, Takahiro Kido, Tetsuya Hoshino, Masahiko Sumitani, Yoshiaki Inoue
BACKGROUND: Pediatric patients, especially in the preverbal stage, cannot self-report intensity of pain therefore several validated observational tools, including the Face, Legs, Activity, Cry, Consolability (FLACC) Behavioral Scale, have been used as a benchmark to evaluate pediatric pain. Unfortunately, this scale is currently unavailable in Japanese, precluding its widespread use in Japanese hospitals. OBJECTIVES: To translate and verify the validity and reliability of the Japanese version of the FLACC Behavioral Scale...
2018: PloS One
Łukasz Szeleszczuk, Dariusz Maciej Pisklak, Monika Zielińska-Pisklak
The aim of this study was to determine whether the periodic density functional theory (DFT) calculations can be used for accurate prediction of the influence of the increased pressure on crystal structure and stability of molecular solids. To achieve this goal a series of geometry optimization and thermodynamic parameters calculations were performed for γ-glycine and δ-glycine structures at different pressure values using CASTEP program. In order to perform most accurate geometry optimization various exchange-correlation functionals defined within generalized gradient approximation (GGA): PBE, PW91, RPBE, WC, PBESOL as well as defined within local density approximation (LDA), i...
March 12, 2018: Journal of Computational Chemistry
D Crivelli, M D Sabogal Rueda, M Balconi
The present work aimed at exploring functional correlates of motor and linguistic representations of everyday actions, with a specific interest in potential sensorimotor activation effects induced by the use of related action sentences. While it is indeed known that observing simple motor acts (e.g., precision grasping) and listening to the sound of specific actions (e.g., walking) activate sensorimotor structures, less is known when we move to more complex behaviors and more abstract linguistic representations (e...
March 12, 2018: Brain Structure & Function
Martin Filipits, Urania Dafni, Michael Gnant, Varvara Polydoropoulou, Margaret Hills, Astrid Kiermaier, Evandro De Azambuja, Denis P Larsimont, Federico Rojo, Giuseppe Viale, Masakazu Toi, Nadia Harbeck, Kathleen I Pritchard, Richard D Gelber, Phuong Dinh, Dimitrios Zardavas, Brian Leyland-Jones, Martine Piccart-Gebhart, Mitch Dowsett
PURPOSE: To assess the prognostic and predictive value of selected biomarkers involved in cell cycle regulation or proliferation in HER2-positive early breast cancer patients. METHODS: Protein expression of TOP2A, Ki67, cyclin D1 and p27 was immunohistochemically determined in tissue microarrays of surgical specimens from 862 patients randomized to trastuzumab (1 or 2 year; N=561) and observation (N=301) arms of the HERA trial. The primary analysis endpoint was disease-free survival (DFS)...
March 12, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
Shenglin Weng, Yiping Li, Jin Wei, Wei Du, Xiaomeng Gao, Wencai Wang, Jianwei Wang, Kumud Acharya, Liancong Luo
The identification of coherent structures is very important in investigating the sediment transport mechanism and controlling the eutrophication in shallow lakes. This study analyzed the turbulence characteristics and the sensitivity of quadrant analysis to threshold level. Simultaneous in situ measurements of velocities and suspended sediment concentration (SSC) were conducted in Lake Taihu with acoustic Doppler velocimeter (ADV) and optical backscatter sensor (OBS) instruments. The results show that the increase in hole size makes the difference between dominant and non-dominant events more distinct...
March 10, 2018: Environmental Science and Pollution Research International
Bahram Javidi, Adam Markman, Siddharth Rawat
We investigate the use of compact, lensless, single random phase encoding (SRPE) and double random phase encoding (DRPE) systems for automatic cell identification when multiple cells, either of the same or mixed classes, are in the field of view. A microscope glass slide containing the sample is inputted into the single or double random phase encoding system, which is then illuminated by a coherent or partially coherent light source generating a unique opto-biological signature (OBS) that is captured by an image sensor...
March 1, 2018: Applied Optics
Tobias Gross, Marc Furrer, Petra Schorno, Patrick Y Wuethrich, Marc P Schneider, George N Thalmann, Fiona C Burkhard
OBJECTIVES: To compare functional and oncological outcomes of reproductive organ sparing cystectomy (ROSC) compared to standard cystectomy (SC) in females undergoing orthotopic ileal bladder substitution (OBS). PATIENTS AND METHODS: From 1995 to 2016, 121 consecutive females undergoing OBS were prospectively included in this single center non-randomized clinical follow up study including a ROSC and SC group. Urinary continence, the need for intermittent self-catheterization (ISC), lateral standing micturition cystourethrogram (MCUG), urethral pressure profiles findings, if available, and oncological outcomes were assessed and compared for ROSC or SC...
March 9, 2018: BJU International
Miranda J Sadar, Michelle G Hawkins, Ian T Taylor, Barbara A Byrne, Lisa A Tell
The objective of this study was to establish the pharmacokinetic parameters of ceftiofur crystalline free acid (CCFA) for a single intramuscular injection in green iguanas ( Iguana iguana). Six green iguanas received an injection of 5 mg/kg CCFA into the triceps muscle. Using high-performance liquid chromatography, concentrations of ceftiofur free acid equivalents in plasma samples collected at predetermined time points were evaluated up to 21 days following drug administration. Noncompartmental pharmacokinetic analysis was applied to the data...
March 2018: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
Yuqing Tang, Xueting Shi, Yongze Liu, Li Feng, Liqiu Zhang
As a potential endocrine disruptor, clofibric acid (CA) was investigated in this study for its degradation kinetics and pathways in UV/chlorine process. The results showed that CA in both UV photolysis and UV/chlorine processes could be degraded via pseudo-first-order kinetics, while it almost could not be degraded in the dark chlorination process. The observed rate constant ( k obs ) in UV photolysis was 0.0078 min-1, and increased to 0.0107 min-1 combining with 0.1 mM chlorine. The k obs increased to 0...
February 2018: Royal Society Open Science
Hanlin Yao, Zhen Yao, Shaocheng Zhang, Wenjun Zhang, Wen Zhou
Osteoporosis is a disease that significantly influences life expectancy and quality in humans. Oxidative stress may stimulate bone marrow osteoclast differentiation and inhibit osteoblast (OB) differentiation. OB proliferation and differentiation are affected by the forkhead box O (FoxO)1/β‑catenin signaling pathway. The osteogenic differentiation of mesenchymal stem cells (MSCs) may be promoted by silent information regulator type‑1 [sirtuin (SIRT)1]. However, the molecular mechanism of SIRT1 regulation of osteogenic differentiation of MSCs remains unclear, and further elucidation is needed...
March 1, 2018: Molecular Medicine Reports
Dulshara Sachini Amarasekara, Hyeongseok Yun, Sumi Kim, Nari Lee, Hyunjong Kim, Jaerang Rho
Cytokines play a pivotal role in maintaining bone homeostasis. Osteoclasts (OCs), the sole bone resorbing cells, are regulated by numerous cytokines. Macrophage colony-stimulating factor and receptor activator of NF-κB ligand play a central role in OC differentiation, which is also termed osteoclastogenesis. Osteoclastogenic cytokines, including tumor necrosis factor-α, IL-1, IL-6, IL-7, IL-8, IL-11, IL-15, IL-17, IL-23, and IL-34, promote OC differentiation, whereas anti-osteoclastogenic cytokines, including interferon (IFN)-α, IFN-β, IFN-γ, IL-3, IL-4, IL-10, IL-12, IL-27, and IL-33, downregulate OC differentiation...
February 2018: Immune Network
Kai Wang, Wenjie Li, Li Dong, Ling Zou, Changming Wang
Combination of electroencephalogram (EEG) recording and functional magnetic resonance imaging (fMRI) plays a potential role in neuroimaging due to its high spatial and temporal resolution. However, EEG is easily influenced by ballistocardiogram (BCG) artifacts and may cause false identification of the related EEG features, such as epileptic spikes. There are many related methods to remove them, however, they do not consider the time-varying features of BCG artifacts. In this paper, a novel method using clustering algorithm to catch the BCG artifacts' features and together with the constrained ICA (ccICA) is proposed to remove the BCG artifacts...
2018: Frontiers in Neuroscience
Bonnie S Jones, Sara Daniel, Lindsay K Cloud
OBJECTIVES: To compare the prevalence and characteristics of facility laws governing abortion provision specifically (targeted regulation of abortion providers [TRAP] laws); office-based surgeries, procedures, sedation or anesthesia (office interventions) generally (OBS laws); and other procedures specifically. METHODS: We conducted cross-sectional legal assessments of state facility laws for office interventions in effect as of August 1, 2016. We coded characteristics for each law and compared characteristics across categories of laws...
February 22, 2018: American Journal of Public Health
Xi Wang, Cheng Chen, Nan Zhang, Jiang Li, Fei Deng, Hualin Wang, Just M Vlak, Zhihong Hu, Manli Wang
Autographa californica nucleopolyhedrovirus (AcMNPV) orf5 (ac5) is a group I alphabaculovirus-specific gene of unknown function, although the protein (AC5) was previously reported to be associated with the per os infectivity factor (PIF) complex. The purpose of this study was to study the dynamics of AC5 during AcMNPV infection and to verify whether it is indeed a component of the PIF complex. Transcription and expression analyses suggested that ac5 is a late viral gene. An ac5-deleted recombinant AcMNPV was generated by homologous recombination...
February 21, 2018: Journal of General Virology
Jian Gao, Jie Zhang, Hong Li, Lei Li, Linghong Xu, Yujie Zhang, Zhanshan Wang, Xuezhong Wang, Weiqi Zhang, Yizhen Chen, Xi Cheng, Hao Zhang, Liang Peng, Fahe Chai, Yongjie Wei
Volatile organic compounds (VOCs) can react with atmospheric radicals while being transported after being emitted, resulting in substantial losses. Using only observed VOC mixing ratios to assess VOC pollution, is therefore problematic. The observed mixing ratios and initial mixing ratios taking chemical loss into consideration were performed using data for 90 VOCs in the atmosphere in a typical urban area in Beijing in winter 2013 to gain a more accurate view of VOC pollution. The VOC sources, ambient VOC mixing ratios and compositions, variability and influencing factors, contributions to near-ground-ozone and health risks posed were assessed...
February 15, 2018: Science of the Total Environment
Tangui Barré, Marlène Perignon, Rozenn Gazan, Florent Vieux, Valérie Micard, Marie-Josèphe Amiot, Nicole Darmon
BACKGROUND: Reducing the consumption of meat and other animal-based products is widely advocated to improve the sustainability of diets in high-income countries. However, such reduction may impair nutritional adequacy, since the bioavailability of key nutrients is higher when they come from animal- vs plant-based foods. Meat reduction may also affect the balance between foods co-produced within the same animal production system. OBJECTIVE: The objective was to assess the impact of introducing nutrient bioavailability and co-production links considerations on the dietary changes needed - especially regarding meat ‒ to improve diet sustainability...
2018: PloS One
Ahmad Masri, Andrew D Althouse, Jeffrey McKibben, Floyd Thoma, Michael Mathier, Ravi Ramani, Jeffrey Teuteberg, Oscar Marroquin, Joon S Lee, Suresh R Mulukutla
BACKGROUND: Patients with heart failure (HF) are admitted either under observation (OBS) or inpatient stays; however, there is little data on whether this designation reflects the clinical status of a patient, with significant logistical and financial implications. We sought to compare the outcomes of patients with HF admitted OBS versus inpatient stay (≤2 days; INPT). METHODS AND RESULTS: From January 1, 2008 to September 30, 2015, our multisite health system saw 21 339 unique patients totaling 52 493 hospital admissions with a primary diagnosis of HF...
January 31, 2018: Journal of the American Heart Association
Sumana Posritong, Jung Min Hong, Pierre P Eleniste, Patrick W McIntyre, Jennifer L Wu, Evan R Himes, Vruti Patel, Melissa A Kacena, Angela Bruzzaniti
Bone remodeling is controlled by the actions of bone-degrading osteoclasts and bone-forming osteoblasts (OBs). Aging and loss of estrogen after menopause affects bone mass and quality. Estrogen therapy, including selective estrogen receptor modulators (SERMs), can prevent bone loss and increase bone mineral density in post-menopausal women. Although investigations of the effects of estrogen on osteoclast activity are well advanced, the mechanism of action of estrogen on OBs is still unclear. The proline-rich tyrosine kinase 2 (Pyk2) is important for bone formation and female mice lacking Pyk2 (Pyk2-KO) exhibit elevated bone mass, increased bone formation rate and reduced osteoclast activity...
February 8, 2018: Molecular and Cellular Endocrinology
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