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Øystein Vesterli Tveiten, Matthew L Carlson, Frederik Goplen, Erling Myrseth, Colin L W Driscoll, Rupavathana Mahesparan, Michael J Link, Morten Lund-Johansen
OBJECTIVE Patient-reported outcomes are increasingly used in studies of vestibular schwannoma (VS); however, few studies have examined self-evaluated facial nerve function and its relation to physician-reported outcomes. The primary objective of this study was to compare patient self-evaluations of facial disability with physician-evaluated facial nerve status and with self-evaluations of a healthy control group. The second objective was to provide insight into the controversial subject of the optimal initial management of small- and medium-sized VSs; consequently, the authors compared patient-reported facial nerve disability following treatment via observation (OBS), Gamma Knife surgery (GKS), or microsurgery (MS)...
December 2, 2016: Journal of Neurosurgery
Ashutosh Chauhan, Mala Mathur Sharma, Kishore Kumar
The purpose of this study was to compare early oncologic outcomes of oncoplastic breast surgery and conventional breast conservation surgery in patients of locally advanced breast cancer. A single-center, prospective, non-randomized study enrolled select cases of locally advanced breast cancer (TNM T3/T4, N0/1/2) who after neoadjuvant chemotherapy, were considered for breast conservation surgery with oncoplasty techniques. The specimen volume resected, the mean margins and mean closest margin obtained were noted...
December 2016: Indian Journal of Surgical Oncology
Marianne Sponer Muhlebach, Valeria Beckett, Elena Popowitch, Melissa B Miller, Arthur Baines, Nicole Mayer-Hamblett, Edith T Zemanick, Wynton C Hoover, Jill M VanDalfsen, Preston Campbell, Christopher H Goss
OBJECTIVE: To evaluate microbiological effectiveness, that is, culture negativity of a non-blinded eradication protocol (Rx) compared with observation (Obs) in clinically stable cystic fibrosis participants with newly positive methicillin resistant Staphylococcus aureus (MRSA) cultures. DESIGN: This non-blinded trial randomised participants ages 4-45 years with first or early (≤2 positive cultures within 3 years) MRSA-positive culture without MRSA-active antibiotics within 4 weeks 1:1 to Rx or Obs...
November 15, 2016: Thorax
Simone D'Angeli, Maria Maddalena Altamura
The olive tree is a plant of economic value for the oil of its drupe. It is a cultigen complex composed of genotypes with differences in cold-hardiness. About 90% of the oil is stored in oil bodies (OBs) in the drupe during the oleogenic phase. Phenols and lipids contribute to oil quality, but the unsaturated fatty acid (FA) fraction is emerging as the most important for quality, because of the very high content in oleic acid, the presence of ω6-linoleic acid and ω3-linolenic acid, and the very low saturated FA content...
November 12, 2016: International Journal of Molecular Sciences
Dengmiao Cheng, Xinhui Liu, Shengnan Zhao, Baoshan Cui, Junhong Bai, Zhaojun Li
Understanding antibiotic adsorption on natural colloids is crucial for prediction of the behavior, bioavailability and toxicity of antibiotics in natural waters. In the present study, the filtered water (dissolved phase, <0.7μm) was further separated into colloidal phase (1kDa-0.7μm) and soluble phase (<1kDa) by cross-flow ultrafiltration (CFUF), and the spatial-temporal variation and distribution of six antibiotics in multi-phases were investigated in Baiyangdian Lake. Results indicated that antibiotic concentrations differed significantly with sampling location and time...
November 11, 2016: Science of the Total Environment
XiaoMeng Gao, Yiping Li, Chunyan Tang, Kumud Acharya, Wei Du, Jianwei Wang, Liancong Luo, Huiyun Li, Shujun Dai, Zhongbo Yu, Jalil Abdul, Wenfei Yu, Shuangshuang Zhang, Robert Bofah-Buoh, Mercy Jepkirui, Xuchuan Lu, Baozhu Pan
Sediment resuspension plays an important role to provide nutrient release for algal growth in large shallow lakes. The settling velocity (w s ) is the key parameter for understanding the suspended sediment transport. In this paper, acoustic Doppler velocimeter (ADV) and optical backscatter sensor (OBS) instruments were used to measure in situ velocities and suspended sediment concentration (SSC) simultaneously without affecting the ambient turbulence in the bottom layer of Lake Taihu. The results showed that (1) ADV echo intensity (EI) could be transferred into SSC successfully by using a simple logarithmic relationship with a strong correlation of 0...
November 10, 2016: Environmental Science and Pollution Research International
Roberto Pasetto, Lucia Fazzo, Amerigo Zona, Caterina Bruno, Roberta Pirastu, Alessandra Binazzi, Marisa Corfiati, Stefano Silvestri, Pietro Comba, Alessandro Marinaccio
BACKGROUND: in Italy, National Priority Contaminated Sites (NPCSs) are defined as of concern for remediation; most of them are sites with a long-lasting industrial activity. OBJECTIVE: the study aims to estimate the burden of disease from mesothelioma in NPCSs. DESIGN: mesothelioma incidence in the period 2000-2011 was estimated for the populations residing in the 39 Italian NPCSs. Data were taken from the Italian National Mesothelioma Registry (ReNaM)...
September 2016: Epidemiologia e Prevenzione
C Vayssière, A Gaudineau, L Attali, K Bettahar, S Eyraud, P Faucher, P Fournet, D Hassoun, M Hatchuel, C Jamin, B Letombe, T Linet, M Msika Razon, A Ohanessian, H Segain, S Vigoureux, N Winer, S Wylomanski, A Agostini
OBJECTIVE: Develop recommendations for the practice of induced abortion. MATERIALS AND METHODS: The Pubmed database, the Cochrane Library and the recommendations from the French and foreign Gyn-Obs societies or colleges have been consulted. RESULTS: The number of induced abortions (IA) has been stable for several decades. There are a lot of factors explaining the choice of abortion when there is an unplanned pregnancy (UPP). Early initiation and choice of contraception in connection to the woman's life are associated with lower NSP...
December 2016: Journal de Gynécologie, Obstétrique et Biologie de la Reproduction
D J Kagedan, M E Dixon, R S Raju, Q Li, M Elmi, E Shin, N Liu, A El-Sedfy, L Paszat, A Kiss, C C Earle, N Mittmann, N G Coburn
BACKGROUND: In the present study, we aimed to describe, at the population level, patterns of adjuvant treatment use after curative-intent resection for pancreatic adenocarcinoma (pcc) and to identify independent predictors of adjuvant treatment use. METHODS: In this observational cohort study, patients undergoing pcc resection in the province of Ontario (population 13 million) during 2005-2010 were identified using the provincial cancer registry and were linked to administrative databases that include all treatments received and outcomes experienced in the province...
October 2016: Current Oncology
Muhammad Afzal Javed, Stephanie Harris, Leslie G Willis, David A Theilmann, B Cameron Donly, Martin A Erlandson, Dwayne D Hegedus
Autographa californica multiple nucleopolyhedrovirus (AcMNPV) is the type species for the genus Alphabaculovirus in the family Baculoviridae. In nature, AcMNPV infection begins with ingestion of viral occlusion bodies (OBs) from which occlusion-derived viruses (ODV) are released to infect midgut cells. This study explored the early stages of Trichoplusia ni midgut infection using recombinant viruses expressing green fluorescent protein (GFP) and/or a VP39-mCherry fusion protein under the control of early and late promoters, respectively...
November 2016: Journal of Invertebrate Pathology
Mengxuan Tang, Davis C Ryman, Eric McDade, Mateusz S Jasielec, Virginia D Buckles, Nigel J Cairns, Anne M Fagan, Alison Goate, Daniel S Marcus, Chengjie Xiong, Ricardo F Allegri, Jasmeer P Chhatwal, Adrian Danek, Martin R Farlow, Nick C Fox, Bernardino Ghetti, Neill R Graff-Radford, Christopher Laske, Ralph N Martins, Colin L Masters, Richard P Mayeux, John M Ringman, Martin N Rossor, Stephen P Salloway, Peter R Schofield, John C Morris, Randall J Bateman
BACKGROUND: Autosomal dominant familial Alzheimer's disease (ADAD) is a rare disorder with non-amnestic neurological symptoms in some clinical presentations. We aimed to compile and compare data from symptomatic participants in the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS) with those reported in the literature to estimate the prevalences of non-amnestic neurological symptoms in participants with ADAD. METHODS: We prospectively collected data from the DIAN-OBS database, which recruited participants from study centres in the USA, Europe, and Australia, between Feb 29, 2008, and July 1, 2014...
December 2016: Lancet Neurology
Maite Arrizubieta, Oihane Simón, Trevor Williams, Primitivo Caballero
A co-occluded binary mixture of Helicoverpa armigera nucleopolyhedrovirus genotypes HearSP1B and HearLB6 at a 1:1 ratio (HearSP1B+HearLB6) was selected for the development of a virus-based biological insecticide, which requires an efficient large-scale production system. In vivo production systems require optimization studies in each host-virus pathosystem. In the present study, the effects of larval instar, rearing density, timing of inoculation, inoculum concentration and temperature on the production of HearSP1B+HearLB6 in its homologous host were evaluated...
2016: PloS One
Hongyu Mi, Mingming Guan, Hongyan Shan, Qiang Fei, Yanfu Huan, Zhiquan Zhang, Guodong Feng
A label-free, highly selective, and highly sensitive fluorescent sensor to detect Hg(2+) was developed using a water-soluble conjugated polymer with carboxylate groups (poly(2,5-bis(sodium 4-oxybutyrate)-1,4-phenylethynylene-alt-1,4-phenyleneethynylene, PPE-OBS) in this work. The fluorescence of PPE-OBS would be quenched because of the effect among the unique coordination-induced aggregation and electron transfers of PPE-OBS toward Hg(2+). The linear relationship between the fluorescence intensity and concentration of Hg(2+) was observed within the range from 6 × 10(-8) to 8 × 10(-5) mol L(-1) (R(2) = 0...
2016: Analytical Sciences: the International Journal of the Japan Society for Analytical Chemistry
Frederick J Ehlert, Richard Sl Stein
We describe a method for estimating the affinities of ligands for active and inactive states of a G protein-coupled receptor (GPCR). Our protocol involves measuring agonist-induced signaling responses of a wild type GPCR and a constitutively active mutant of it under control conditions and after partial receptor inactivation or reduced receptor expression. Our subsequent analysis is based on the assumption that the activating mutation increases receptor isomerization into the active state without affecting the affinities of ligands for receptor states...
October 7, 2016: Journal of Pharmacological and Toxicological Methods
Igor Diemberger, Giulia Massaro, Maria Letizia Bacchi Reggiani, Stefano Lorenzetti, Mauro Biffi, Matteo Ziacchi, Cristian Martignani, Giuseppe Boriani
Dronedarone was found to have divergent safety profiles in randomized controlled trials (RCT) in term of cardiac death and overall mortality. We decided to evaluate all available evidence on the cardiovascular safety of this drug. A systematic search was made of the MEDLINE and the Cochrane Central Register of Controlled Trials from January 2003 through April 2016 for RCT comparing dronedarone to placebo/active control, to provide the most accurate estimate of the effects of this agent and observational cohort studies (OBS) reporting clinical outcomes in patients treated with dronedarone, according to current guidelines, to obtain a real-life comparator for the findings summarized by RTC analysis...
October 6, 2016: Current Pharmaceutical Design
Romain Rivoirard, Vianney Duplay, Mathieu Oriol, Fabien Tinquaut, Franck Chauvin, Nicolas Magne, Aurelie Bourmaud
BACKGROUND: Quality of reporting for Randomized Clinical Trials (RCTs) in oncology was analyzed in several systematic reviews, but, in this setting, there is paucity of data for the outcomes definitions and consistency of reporting for statistical tests in RCTs and Observational Studies (OBS). The objective of this review was to describe those two reporting aspects, for OBS and RCTs in oncology. METHODS: From a list of 19 medical journals, three were retained for analysis, after a random selection: British Medical Journal (BMJ), Annals of Oncology (AoO) and British Journal of Cancer (BJC)...
2016: PloS One
David Gilbert
No abstract text is available yet for this article.
September 26, 2016: Medical Humanities
Goran Baranović
Three refractive index mixing rules, Arago-Biot, Lorentz-Lorenz, and Newton, are generalized to complex refractive index and used to define infrared (IR) spectra of the corresponding ideal liquid mixtures. Using the measured optical constants n and k for acetonitrile-water mixtures (Bertie and Lan, 1997) the excess absorbances, A(E )= A(obs) - A(ideal), are calculated. Relying upon the well-established properties of the acetonitrile-water mixtures, the interpretation of the excess absorbances is established that is essentially based on the understanding of a liquid as a set of oscillators...
September 19, 2016: Applied Spectroscopy
Marie Denizet, Laurent Cotter, Pierre-Marie Lledo, Françoise Lazarini
The olfactory bulb (OB) is a highly plastic structure that can change organizational networks depending on environmental inputs in adult mammals. Particularly, in rodents, adult neurogenesis underlies plastic changes in the OB circuitry by continuously adding new interneurons to the network. We addressed the question of whether microglia, the immune cells of the brain, were involved in pruning OB neurons. Using lentiviral labeling of neurons in neonatal or adult mice and confocal analysis, we showed that microglia engulfed parts of neonatal-born and adult-born neurons in the healthy OB...
September 15, 2016: Brain, Behavior, and Immunity
Rongbing Fu, Zhen Xu, Lin Peng, Dongsu Bi
In this study, nanoscale zerovalent iron (NZVI) immobilized on biomass carbon was used for the high efficient removal of BDE 209. NZVI supported on biomass carbon minimized the aggregation of NZVI particles resulting in the increased reaction performance. The proposed removal mechanism included the adsorption of BDE 209 on the surface or interior of the biomass carbon NZVI (BC-NZVI) particles and the subsequent debromination of BDE 209 by NZVI while biomass carbon served as an electron shuttle. BC-NZVI particles and the interaction between BC-NZVI particles and BDE 209 were characterized by TEM, XRD, and XPS...
December 2016: Environmental Science and Pollution Research International
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