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https://www.readbyqxmd.com/read/29133632/uveal-effusion-syndrome-in-104-eyes-response-to-corticosteroids-the-2017-axel-c-hansen-lecture
#1
Carol L Shields, Kelsey Roelofs, Maura Di Nicola, Kareem Sioufi, Arman Mashayekhi, Jerry A Shields
PURPOSE: The purpose of the study was to investigate the corticosteroids for uveal effusion syndrome (UES). METHODS: Retrospective series of 104 eyes with UES treated with oral corticosteroids (OCS), periocular corticosteroids (PCS), topical corticosteroids (TCS), or observation (OBS). Main outcome measure was UES resolution. RESULTS: Of 104 eyes, treatment included OCS (n = 27), PCS (n = 12), TCS (n = 11), and OBS (n = 54). A comparison of the four groups (OCS vs...
November 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29124044/index-based-dietary-patterns-and-the-risk-of-prostate-cancer
#2
REVIEW
Ji Hyun Kim, Jeongseon Kim
Prostate cancer is the second leading cause for cancer incidence in male. Although this high incidence is due to prostate specific antigen screening, other risk-factors, such as diet, might also be involved. The results of previous studies on the association between prostate cancer risk and individual dietary components have been conflicting. Thus, evaluation by dietary pattern analysis rather than individual dietary factors is suggested. The purpose of this study was to review the association of prostate cancer with a priori dietary indices, which are less studied and reviewed to date compared to a posteriori indices...
October 2017: Clinical Nutrition Research
https://www.readbyqxmd.com/read/29115171/sika-pilose-antler-type-i-collagen-promotes-bmsc-differentiation-via-the-erk1-2-and-p38-mapk-signal-pathways
#3
Yanshuang Wang, Su Luo, Dafang Zhang, Xiaobo Qu, Yinfeng Tan
CONTEXT: Sika pilose antler type I collagen (SPC-I) have been reported to promote bone marrow mesenchymal stem cell (BMSC) proliferation and differentiation. However, the underlying mechanism is still unclear. OBJECTIVE: This study investigates the molecular mechanisms of SPC-I on the BMSC proliferation and differentiation of osteoblast (OB) in vitro. MATERIAL AND METHODS: The primary rat BMSC was cultured and exposed to SPC-I at different concentrations (2...
December 2017: Pharmaceutical Biology
https://www.readbyqxmd.com/read/29109676/oxytocin-removes-estrous-female-vs-male-preference-of-virgin-male-rats-mediation-of-the-supraoptic-nucleus-via-olfactory-bulbs
#4
Xiao-Yu Liu, Dan Cui, Dongyang Li, Runsheng Jiao, Xiaoran Wang, Shuwei Jia, Dan Hou, Tong Li, Haitao Liu, Ping Wang, Yu-Feng Wang
Social functions of oxytocin (OT) have been explored extensively; however, relationship between the effect of intranasally applied OT (nasal OT) on the social preference (SP) and intracerebral actions of endogenous OT remains unclear. To resolve this question, we first observed effects of nasal OT on the SP of virgin young adult male rats toward unfamiliar virgin estrous female (EF) vs. virgin male rats. The results showed that the test male rats exhibited significantly more times and longer duration accessing the female than the male, which were acutely eliminated by nasal OT...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/29107124/genetic-inhibition-of-ppar%C3%AE-s112-phosphorylation-reduces-bone-formation-and-stimulates-marrow-adipogenesis
#5
Chunxi Ge, Guisheng Zhao, BinBin Li, Yan Li, William P Cawthorn, Ormond A MacDougald, Renny T Franceschi
A common feature of many skeletal diseases is the accumulation of marrow fat. A reciprocal relationship exists between osteogenesis and adipogenesis in bone marrow that is mediated by the relative activity of PPARγ and RUNX2 transcription factors. The ERK/MAPK pathway is an important inducer of MSC differentiation to osteoblasts and an inhibitor of adipogenesis that functions by phosphorylating RUNX2 and PPARγ. To begin to assess the importance of this regulation in vivo, we examined the consequences of blocking one arm of this pathway, PPARγ S112 phosphorylation, by evaluating the bone phenotype of PPARγ S112A mutant mice...
October 26, 2017: Bone
https://www.readbyqxmd.com/read/29065456/the-operophtera-brumata-nucleopolyhedrovirus-opbunpv-represents-an-early-divergent-lineage-within-genus-alphabaculovirus
#6
Robert L Harrison, Daniel L Rowley, Joseph D Mowery, Gary R Bauchan, John P Burand
Operophtera brumata nucleopolyhedrovirus (OpbuNPV) infects the larvae of the winter moth, Operophtera brumata. As part of an effort to explore the pesticidal potential of OpbuNPV, an isolate of this virus from Massachusetts (USA)-OpbuNPV-MA-was characterized by electron microscopy of OpbuNPV occlusion bodies (OBs) and by sequencing of the viral genome. The OBs of OpbuNPV-MA consisted of irregular polyhedra and contained virions consisting of a single rod-shaped nucleocapsid within each envelope. Presumptive cypovirus OBs were also detected in sections of the OB preparation...
October 21, 2017: Viruses
https://www.readbyqxmd.com/read/29058257/kinetics-and-pathways-of-bezafibrate-degradation-in-uv-chlorine-process
#7
Xue-Ting Shi, Yong-Ze Liu, Yu-Qing Tang, Li Feng, Li-Qiu Zhang
UV/chlorine, as a novel disinfection method, has attracted great interest due to its effective removal for pathogenic microorganism and degradation of trace organic contaminants existed in water environment. This paper investigated the degradation kinetics and pathways of Bezafibrate (BZF), a typical antilipemic drug, during UV/chlorine process. The results showed that 92.3% of BZF was degraded after 20 min in UV/chlorine process. This indicated HO• and reactive chlorine species (RCSs) formed in UV/chlorine played the dominant role in degrading BZF...
October 20, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29050232/progressive-modulation-of-the-human-olfactory-bulb-transcriptome-during-alzheimer%C3%A2-s-disease-evolution-novel-insights-into-the-olfactory-signaling-across-proteinopathies
#8
Mercedes Lachen-Montes, María Victoria Zelaya, Víctor Segura, Joaquín Fernández-Irigoyen, Enrique Santamaría
Alzheimer´s disease (AD) is characterized by progressive dementia, initially presenting olfactory dysfunction. Despite the olfactory bulb (OB) is the first central structure of the olfactory pathway, we lack a complete molecular characterization of the transcriptional events that occurs in this olfactory area during AD progression. To address this gap in knowledge, we have assessed the genome-wide expression in postmortem OBs from subjects with varying degree of AD pathology. A stage-dependent deregulation of specific pathways was observed, revealing transmembrane transport, and neuroinflammation as part of the functional modules that are disrupted across AD grading...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29039656/highly-symmetric-ab2-framework-related-to-tridymite-in-the-disordered-nitridosilicate-la24sr14-7x-si36n72-o1-xfx-14-x-0-489
#9
Lukas Neudert, Dajana Durach, Felix Fahrnbauer, Gavin B M Vaughan, Wolfgang Schnick, Oliver Oeckler
La24Sr14-7x[Si36N72](O1-xFx)14 with x = 0.489 was obtained as a microcrystalline product by metathesis at 1500 °C in a radio-frequency furnace starting from Si(NH)2, La(NH2)3, SrH2, LaF3, and CeF3. The structure of the new nitridosilicate oxide fluoride was determined by combining transmission electron microscopy (TEM) and single-crystal X-ray diffraction using a microfocused synchrotron beam. The structure model with pronounced disorder [P63/mmc, Z = 1, a = 16.2065(3), c = 9.4165(1) Å, R1(obs) = 0.0436] was confirmed by electron diffraction and aberration-corrected Z-contrast scanning TEM...
November 6, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/29037921/tlr-expression-profile-of-human-alveolar-bone-proper-derived-stem-progenitor-cells-and-osteoblasts
#10
Karim M Fawzy El-Sayed, Josephine Boeckler, Christof E Dörfer
Alveolar bone proper-derived mesenchymal stem/progenitor cells (AB-MSCs) and alveolar osteoblasts (OBs) are pivotal cells with positive attributes in regenerative medicine. During regenerative approaches, AB-MSCs may interact with their surrounding environment via their expressed toll-like-receptors (TLRs). This study aimed to depict for the first time the TLRs expression profile of AB-MSCs and OBs. Cells were isolated from human alveolar bone proper, and STRO-1-immunomagnetically sorted to segregate AB-MSCs and OBs...
September 18, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/29027106/fas-and-mitochondria-mediated-signaling-pathway-involved-in-osteoblast-apoptosis-induced-by-alcl3
#11
Feibo Xu, Limin Ren, Miao Song, Bing Shao, Yanfei Han, Zheng Cao, Yanfei Li
Aluminum (Al) is known to induce apoptosis of osteoblasts (OBs). However, the mechanism is not yet established. To investigate the apoptotic mechanism of OBs induced by aluminum trichloride (AlCl3), the primary OBs from the craniums of fetal Wistar rats were exposed to 0 mg/mL (control group, CG), 0.06 mg/mL (low-dose group, LG), 0.12 mg/mL (mid-dose group, MG), and 0.24 mg/mL (high-dose group, HG) AlCl3 for 24 h, respectively. We observed that AlCl3 induced OB apoptosis with the appearance of apoptotic morphology and increase of apoptosis rate...
October 12, 2017: Biological Trace Element Research
https://www.readbyqxmd.com/read/28991994/technical-note-validation-of-an-automated-system-for-monitoring-and-restricting-water-intake-in-group-housed-beef-steers
#12
K Allwardt, C Ahlberg, A Broocks, K Bruno, A Taylor, S Place, C Richards, C Krehbiel, M Calvo-Lorenzo, U DeSilva, D VanOverbeke, R Mateescu, C Goad, M M Rolf
The Insentec Roughage Intake Control (RIC) system has been validated for the collection of water intake; however, this system has not been validated for water restriction. The objective of this validation was to evaluate the agreement between direct observations and automated intakes collected by the RIC system under both ad libitum and restricted water conditions. A total of 239 crossbred steers were used in a 3-d validation trial, which assessed intake values generated by the RIC electronic intake monitoring system for both ad libitum water intake ( = 122; BASE) and restricted water intake ( = 117; RES)...
September 2017: Journal of Animal Science
https://www.readbyqxmd.com/read/28975679/an-emergency-department-observation-unit-is-a-feasible-setting-for-multidisciplinary-geriatric-assessments-in-compliance-with-the-geriatric-emergency-department-guidelines
#13
Lauren T Southerland, Anthony J Vargas, Lalitha Nagaraj, Tanya R Gure, Jeffery M Caterino
BACKGROUND: The Geriatric Emergency Department Guidelines recommend providing multidisciplinary geriatric assessment in the Emergency Department (ED), but these assessments can be difficult to coordinate and may prolong length of stay. Patients who need longer than a typical ED stay can be placed in an ED Observation Unit (Obs Unit). We investigated the effects of offering multidisciplinary assessments for ED patients in an Obs Unit. METHODS: Evaluation by a geriatric hospital consultation team, physical therapist, case manager, and/or pharmacist was made available to all Obs Unit patients...
October 4, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28974845/challenges-in-the-routine-praxis-diagnosis-of-hydatidiform-mole-a-tertiary-health-center-experience
#14
Melisa Lelic, Zlatan Fatusic, Ermina Iljazovic, Suada Ramic, Sergije Markovic, Selma Alicelebic
INTRODUCTION: Hydatidiform moles (HM), presenting as complete (CHM) and partial (PHM) form, are rare pregnancy disorder. Diagnosis is based on clinical presentation, ultrasound imaging findings and pathological examination of products of conception. Protein p57, encoded by CKDN1C gene, is paternally imprinted and maternally expressed gene and provides quick insight in genetic basis of HM and allows distinction of CHM from all other conceptions. compare the preevacuational and pathohistological diagnosis with outcome of p57 immunostaining...
August 2017: Medical Archives
https://www.readbyqxmd.com/read/28972124/activity-patterns-elicited-by-airflow-in-the-olfactory-bulb-and-their-possible-functions
#15
Ruiqi Wu, Yue Liu, Li Wang, Bo Li, Fuqiang Xu
Olfactory sensory neurons (OSNs) can sense both odorants and airflows. In the olfactory bulb (OB), the coding of odor information has been well studied, but the coding of mechanical stimulation is rarely investigated. Unlike odor-sensing functions of OSNs, the airflow-sensing functions of OSNs are also largely unknown. Here, the activity patterns elicited by mechanical airflow in male rat OBs were mapped using fMRI and correlated with local field potential recordings. In an attempt to reveal possible functions of airflow sensing, the relationship between airflow patterns and physiological parameters was also examined...
November 1, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28970231/the-terminal-nerve-plays-a-prominent-role-in-gnrh-1-neuronal-migration-independent-from-proper-olfactory-and-vomeronasal-connections-to-the-olfactory-bulbs
#16
Ed Zandro M Taroc, Aparna Prasad, Jennifer M Lin, Paolo E Forni
Gonadotropin-releasing hormone-1 (GnRH-1) neurons (GnRH-1 ns) migrate from the developing olfactory pit into the hypothalamus during embryonic development. Migration of the GnRH-1 neurons is required for mammalian reproduction as these cells control release of gonadotropins from the anterior pituitary gland. Disturbances in GnRH-1 ns migration, GnRH-1 synthesis, secretion or signaling lead to varying degrees of hypogonadotropic hypogonadism (HH), which impairs pubertal onset and fertility. HH associated with congenital olfactory defects is clinically defined as Kallmann Syndrome (KS)...
October 15, 2017: Biology Open
https://www.readbyqxmd.com/read/28958552/a-two-chain-aspartic-protease-present-in-seeds-with-high-affinity-for-peanut-oil-bodies
#17
Yeming Chen, Yajing Chen, Luping Zhao, Xiangzhen Kong, Zhaoqi Yang, Yufei Hua
Peanut seeds are rich in oil, which exists as oil bodies (OBs). By extraction, peanut crude OBs are obtained and can be used as a food ingredient. In a previous study, it was found that the crude OBs contained an unknown protease, which hydrolyzed the oleosins. This would disrupt the integrity of OBs, and therefore, affect their physical and oxidative stability. In this study, the protein composition of crude OBs and some properties of the unknown protease were examined. The results showed that the protease was a two-chain (32 and 9kDa) aspartic protease, which showed high affinity for OBs...
February 15, 2018: Food Chemistry
https://www.readbyqxmd.com/read/28934787/complex-regional-pain-syndrome-type-i-a-debilitating-and-poorly-understood-syndrome-possible-role-for-pulsed-electromagnetic-fields-a-narrative-review
#18
Stefania Pagani, Francesca Veronesi, Nicolo Nicoli Aldini, Milena Fini
BACKGROUND: Complex regional pain syndrome type I (CRPS-I), also called algodystrophy, is a complex syndrome characterized by limb pain, edema, allodynia, hyperalgesia and functional impairment of bone with a similar clinical picture of osteoporosis, including an increased release of various pro-inflammatory neuropeptides and cytokines. Several treatments have been proposed for CRPS-I, but due to the poor outcome of conventional drugs and the invasiveness of some techniques, expectations are now directed towards new resources that could be more effective and less invasive...
September 2017: Pain Physician
https://www.readbyqxmd.com/read/28904203/three-conserved-regions-in-baculovirus-sulfhydryl-oxidase-p33-are-critical-for-enzymatic-activity-and-function
#19
Wenhua Kuang, Huanyu Zhang, Manli Wang, Ning-Yi Zhou, Fei Deng, Hualin Wang, Peng Gong, Zhihong Hu
Baculoviruses encode a conserved sulfhydryl oxidase P33, which is necessary for budded virus (BV) production and multi-nucleocapsid occlusion-derived virus (ODV) formation. Here, the structural and functional relationship of P33 was revealed by X-ray crystallography, site-directed mutagenesis, and functional analysis. Based on crystallographic characterization and structural analysis, a series of P33 mutants within three conserved regions, i.e. the active site, dimer interface, and the R127-E183 salt bridge, were constructed...
September 13, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28886869/immunohistochemical-study-of-arginases-1-and-2-in-the-olfactory-bulbs-of-the-korean-roe-deer-capreolus-pygargus
#20
Jeongtae Kim, Meejung Ahn, Yuna Choi, Ji-Yeon Hyeon, Taekyun Shin
Arginases are enzymes of the urea cycle that catalyze the hydrolysis of l-arginine to ornithine and urea. The enzymes are core components of the arginine-ornithine-glutamate-γ-amino butyric acid pathway of the central nervous system. In the present study, we immunohistochemically determined the localization of arginase 1 and 2 in the olfactory bulb (OB) of the roe dear (Capreolus pygargus). Reverse transcription PCR revealed that the mRNAs encoding both arginase 1 and 2 were expressed in the OB. Arginase 1 was localized to olfactory nerve axons, calcitonin gene-related peptide-positive mitral/tufted cells (excitatory neurons), and glutamate acid decarboxylase 65/67-immunopositive periglomerular cells of the main olfactory bulb...
September 5, 2017: Acta Histochemica
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