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https://www.readbyqxmd.com/read/29221458/a-cohort-examination-to-establish-reporting-of-the-remit-and-function-of-trial-steering-committees-in-randomised-controlled-trials
#1
Elizabeth J Conroy, Barbara Arch, Nicola L Harman, J Athene Lane, Steff C Lewis, John Norrie, Matthew R Sydes, Carrol Gamble
BACKGROUND: The DAMOCLES project established a widely used Data Monitoring Committee (DMC) Charter for randomised controlled trials (RCTs). Typically, within the UK, the DMC is advisory and recommends to another executive body; the Trial Steering Committee (TSC). Despite the executive role of the TSC, the CONSORT Statement does not explicitly require reporting of TSC activity, although is included as an example of good reporting. A lack of guidance on TSC reporting can impact transparency of trial oversight, ultimately leading to a misunderstanding regarding role and, subsequently, further variation in practice...
December 8, 2017: Trials
https://www.readbyqxmd.com/read/29214665/cephalic-muscle-development-in-the-australian-lungfish-neoceratodus-forsteri
#2
Janine M Ziermann, Alice M Clement, Rolf Ericsson, Lennart Olsson
Lungfishes are the extant sister group of tetrapods. As such, they are important for the study of evolutionary processes involved in the water to land transition of vertebrates. The evolution of a true neck, that is, the complete separation of the pectoral girdle from the cranium, is one of the most intriguing morphological transitions known among vertebrates. Other salient changes involve new adaptations for terrestrial feeding, which involves both the cranium and its associated musculature. Historically, the cranium has been extensively investigated, but the development of the cranial muscles much less so...
December 7, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/29213322/deletion-of-the-hfsb-gene-increases-ethanol-production-in-thermoanaerobacterium-saccharolyticum-and-several-other-thermophilic-anaerobic-bacteria
#3
Ayşenur Eminoğlu, Sean Jean-Loup Murphy, Marybeth Maloney, Anthony Lanahan, Richard J Giannone, Robert L Hettich, Shital A Tripathi, Ali Osman Beldüz, Lee R Lynd, Daniel G Olson
Background: With the discovery of interspecies hydrogen transfer in the late 1960s (Bryant et al. in Arch Microbiol 59:20-31, 1967), it was shown that reducing the partial pressure of hydrogen could cause mixed acid fermenting organisms to produce acetate at the expense of ethanol. Hydrogen and ethanol are both more reduced than glucose. Thus there is a tradeoff between production of these compounds imposed by electron balancing requirements; however, the mechanism is not fully known...
2017: Biotechnology for Biofuels
https://www.readbyqxmd.com/read/29195211/supporting-those-who-work-and-learn-a-phenomenological-research-study
#4
Claire Thurgate
AIM: With a shift in the United Kingdom's National Health Service to organisational learning and the local introduction of the Assistant Practitioner role to support the nursing workforce there was a broad need to understand the lived experiences of those who work and learn. METHOD: Hermeneutic phenomenology was the chosen methodology. A purposive sample of eight trainee assistant practitioners, four matrons, seven mentors and the practice development nurse participated in conversational interviews at intermittent points in the journey...
November 15, 2017: Nurse Education Today
https://www.readbyqxmd.com/read/29191608/a-fully-digital-approach-to-replicate-functional-and-aesthetic-parameters-in-implant-supported-full-arch-rehabilitation
#5
Carlo Monaco, Nicola Ragazzini, Lorenzo Scheda, Edoardo Evangelisti
PURPOSE: The aim of this technical procedure was to use a fully digital technique (FDT) for full-arch implant support rehabilitation. The FDT was used to transfer the provisional restoration parameters to definitive restorations using intraoral scanners. METHODS: Three sets of digital impressions were obtained. Through the first set, standard tessellation language 1 (STL1), provisional restorations screwed to implants and the surrounding gingival tissue was captured...
November 27, 2017: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/29182488/the-influence-of-prosthesis-design-on-the-outcomes-of-tooth-implants-immediately-placed-and-loaded-by-means-of-one-piece-titanium-restoration
#6
Paolo Toti, Simone Marconcini, Enrica Giammarinaro, Giorgio Pedretti, Antonio Barone, Ugo Covani
Our purpose was to evaluate the occurrence of complications, and the degree of bone loss in a cohort of patients treated with fixed prostheses supported by immediately loaded dental implants. The primary aim was to compare partial versus full-arch Fixed Dental Prostheses. We then tested the effect of sinus lifting. In the present retrospective cohort study, the patients had their implants restored with Fixed Dental Prostheses supported by dental implants positioned in the posterior maxilla and mandible. When necessary, the maxillary sinuses were grafted with particulate autogenous bone...
November 28, 2017: Journal of Oral Implantology
https://www.readbyqxmd.com/read/29175714/the-effect-of-additional-activation-of-the-plantar-intrinsic-foot-muscles-on-foot-dynamics-during-gait
#7
Kazunori Okamura, Shusaku Kanai, Masaki Hasegawa, Akira Otsuka, Sadaaki Oki
BACKGROUND: The plantar intrinsic foot muscles (PIFMs) contribute to support the medial longitudinal arch. But the functional role of the PIFMs during dynamic activities is not clear. The purpose of this study was to examine the change in the foot dynamics during gait accompanied with the change in the PIFMs activity to determine the functional role of the PIFMs during gait. METHODS: Twenty healthy male subjects were randomly assigned to the electrical stimulation group (ESG) or control group (CG)...
August 18, 2017: Foot
https://www.readbyqxmd.com/read/29174374/tracheobronchial-stenting-for-airway-malacia
#8
REVIEW
Colin Wallis, Clare A McLaren
Tracheobronchomalacia is a rare but clinically troublesome condition in paediatrics. The softening of the major airways - which can include some or all of the tracheobronchial tree can lead to symptoms ranging from the minor (harsh barking cough, recurrent chest infections) to severe respiratory difficulties including prolonged ventilator support and 'near death attacks'. The causes are broadly divided into intrinsic softening of the airway wall which is considered a primary defect (e.g. syndromes; post tracheo-oesophageal fistula repair; extreme prematurity) or secondary malacia due to external compression from vascular structures or cardiac components...
October 13, 2017: Paediatric Respiratory Reviews
https://www.readbyqxmd.com/read/29155537/case-study-management-of-a-loose-upper-denture-opposed-by-a-shortened-dental-arch
#9
Laurie Powell
For many years, it has been considered necessary to restore posterior support with a bilateral free-end saddle when a full upper denture is opposed by a shortened dental arch. It was thought that this would provide occlusal stability and prevent anterior bite collapse and temporomandibular dysfunction. As free-end saddle partial dentures are often poorly tolerated by patients, this case study tests whether a retentive full-upper denture occluding with a shortened dental arch offers enough to fulfil a patient’s needs...
December 2016: Dental Update
https://www.readbyqxmd.com/read/29145527/evaluation-of-operating-time-and-patient-perception-using-conventional-impression-taking-and-intraoral-scanning-for-crown-manufacture-a-split-mouth-randomized-clinical-study
#10
Yasser Haddadi, Golnosh Bahrami, Flemming Isidor
PURPOSE: To compare operating time and patient perception of conventional impression (CI) taking and intraoral scanning (IOS) for manufacture of a tooth-supported crown. MATERIALS AND METHODS: A total of 19 patients needing indirect full-coverage restorations fitting the requirements for a split-mouth design were recruited. Each patient received two lithium disilicate crowns, one manufactured from CI taking and one from IOS. Both teeth were prepared following the manufacturers' recommendations...
November 16, 2017: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/29140381/consistency-of-dental-hygiene-therapy-utilizing-various-dental-hygiene-instrumentation-and-its-effect-on-peri-implant-health-and-survival-of-dental-implants-a-retrospective-study
#11
Sarah B Hoerler, Sandra K Nietz, Victoria L Zook, Christine M Lohse, Thomas J Salinas, Alan B Carr, Daniel A Assad
PURPOSE: The purpose of this retrospective study was to provide practice-based evidence to determine if the consistency of dental hygiene therapy, despite utilizing instrumentation literature that has proven to cause alterations to implant surfaces, affects peri-implant health or survival. MATERIALS AND METHODS: The study sample comprised patients with implant-supported full-arch fixed dental prostheses who were distributed into two groups. The consistent hygiene group patients had dental hygiene therapy at a minimum biannually and were exposed to at least three dental hygiene instrument materials...
November 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29140379/seven-year-follow-up-of-full-arch-prostheses-supported-by-four-implants-a-prospective-study
#12
Karen Vaz Ayub, Eduardo Antônio Ayub, Accácio Lins do Valle, Gerson Bonfante, Thiago Pegoraro, Luiz Fernando
PURPOSE: To evaluate biologic and prosthetic outcomes of implant-supported mandibular full-arch fixed prostheses treated with the All-on-4 treatment concept after 7 years. MATERIALS AND METHODS: Patients were selected to receive full-arch fixed immediate prostheses supported by four implants up to 72 hours after surgery. The following biologic aspects were evaluated: Plaque Index (PI) and Bleeding Index (BI), implant stability by resonance frequency, and marginal bone loss (MBL) measured with the aid of periapical radiographs...
November 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29140378/perception-by-osseointegrated-dental-implants-supporting-a-fixed-prosthesis-a-prospective-study
#13
Purva V Bakshi, Srinath Thakur, Sudhindra Kulkarni
PURPOSE: Osseointegrated implants have been shown to transmit a certain sensibility termed as osseoperception. The purpose of this study was to determine the perception by implants over a period of 6 months after loading in comparison to the natural dentition. MATERIALS AND METHODS: Twenty subjects (ages 40 to 50 years) were included in this split-mouth clinical trial. The subjects were divided into two groups (n = 10) as follows: group 1-subjects with recently cemented implant-supported fixed prosthesis opposing natural teeth; group 2-subjects with recently cemented implant-supported fixed prosthesis in both arches...
November 2017: International Journal of Oral & Maxillofacial Implants
https://www.readbyqxmd.com/read/29125457/emended-description-of-the-genus-phytobacter-its-type-species-phytobacter-diazotrophicus-zhang-2008-and-description-of-phytobacter-ursingii-sp-nov
#14
Marcelo Pillonetto, Lavinia N Arend, Helisson Faoro, Helena R S D'Espindula, Jochen Blom, Theo H M Smits, Marcelo T Mira, Fabio Rezzonico
The species Phytobacter diazotrophicus and the associated genus Phytobacter were originally described by Zhanget al. [Arch Microbiol189 (2008), 431-439] on the basis of few endophytic nitrogen-fixing bacteria isolated from wild rice (Oryza rufipogon) in China. In this study, we demonstrate that a number of clinical isolates that were either described in the literature, preserved in culture collections, or obtained during a 2013 multi-state sepsis outbreak in Brazil also belong to the same genus. 16S rRNA gene sequencing, multilocus sequence analysis based on gyrB, rpoB, atpD and infB genes, as well as digital DNA-DNA hybridization support the existence of a second species within the genus Phytobacter...
November 10, 2017: International Journal of Systematic and Evolutionary Microbiology
https://www.readbyqxmd.com/read/29100060/network-analysis-reveals-a-causal-role-of-mitochondrial-gene-activity-in-atherosclerotic-lesion-formation
#15
Baiba Vilne, Josefin Skogsberg, Hassan Foroughi Asl, Husain Ahammad Talukdar, Thorsten Kessler, Johan L M Björkegren, Heribert Schunkert
BACKGROUND AND AIMS: Mitochondrial damage and augmented production of reactive oxygen species (ROS) may represent an intermediate step by which hypercholesterolemia exacerbates atherosclerotic lesion formation. METHODS: To test this hypothesis, in mice with severe but genetically reversible hypercholesterolemia (i.e. the so called Reversa mouse model), we performed time-resolved analyses of mitochondrial transcriptome in the aortic arch employing a systems-level network approach...
October 21, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29075419/bimaxillary-simultaneous-immediate-loading-of-full-arch-restorations-a-case-series
#16
REVIEW
Iñaki Cercadillo-Ibarguren, Alba Sánchez-Torres, Rui Figueiredo, Eduard Valmaseda-Castellón
AIM: To describe a bimaxillary simultaneous immediate loading protocol with full-arch implant-supported fixed prostheses. MATERIAL AND METHODS: A prospective case series of 8 patients who required full-arch rehabilitation was conducted. The main inclusion criteria were patients with teeth that required extraction. At least 1 molar per arch was temporarily employed to stabilize the surgical template and the provisional prosthesis during intraoral relining. RESULTS: Two upper implants failed in 1 patient...
September 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29065668/how-arch-support-insoles-help-persons-with-flatfoot-on-uphill-and-downhill-walking
#17
Yu-Ping Huang, Kwantae Kim, Chen-Yi Song, Yat-Hon Chen, Hsien-Te Peng
The main purpose of this study was to investigate the effect of arch support insoles on uphill and downhill walking of persons with flatfoot. Sixteen healthy college students with flatfoot were recruited in this study. Their heart rate, peak oxygen uptake (VO2), and median frequency (MDF) of surface electromyogram were recorded and analyzed. Nonparametric Wilcoxon signed-rank test was used for statistical analysis. The main results were as follows: (a) peak VO2 significantly decreased with arch support insoles compared with flat insoles during uphill and downhill walking (arch support insole versus flat insole: uphill walking, 20...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29065655/the-effect-of-arch-height-and-material-hardness-of-personalized-insole-on-correction-and-tissues-of-flatfoot
#18
Shonglun Su, Zhongjun Mo, Junchao Guo, Yubo Fan
Flat foot is one of the common deformities in the youth population, seriously affecting the weight supporting and daily exercising. However, there is lacking of quantitative data relative to material selection and shape design of the personalized orthopedic insole. This study was to evaluate the biomechanical effects of material hardness and support height of personalized orthopedic insole on foot tissues, by in vivo experiment and finite element modeling. The correction of arch height increased with material hardness and support height...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29062444/laparoscopic-repair-of-large-suprapubic-hernias
#19
Hasan Ediz Sikar, Kenan Çetin, Kemal Eyvaz, Levent Kaptanoglu, Hasan Fehmi Küçük
INTRODUCTION: Suprapubic hernia is the term to describe ventral hernias located less than 4 cm above the pubic arch in the midline. Hernias with an upper margin above the arcuate line encounter technical difficulties, and the differences in repair methods forced us to define them as large suprapubic hernias. AIM: To present our experience with laparoscopic repair of large suprapubic hernias that allows adequate mesh overlap. MATERIAL AND METHODS: Nineteen patients with suprapubic incisional hernias who underwent laparoscopic repair between May 2013 and January 2015 were included in the study...
September 2017: Wideochirurgia i Inne Techniki Mało Inwazyjne, Videosurgery and Other Miniinvasive Techniques
https://www.readbyqxmd.com/read/29061637/unique-developmental-trajectories-and-genetic-regulation-of-ventricular-and-outflow-tract-progenitors-in-the-zebrafish-second-heart-field
#20
Noelle Paffett-Lugassy, Natasha Novikov, Spencer Jeffrey, Maryline Abrial, Burcu Guner-Ataman, Srinivasan Sakthivel, Caroline E Burns, C Geoffrey Burns
During mammalian embryogenesis, cardiac progenitor cells constituting the second heart field (SHF) give rise to the right ventricle and primitive outflow tract (OFT), the latter of which is particularly vulnerable to developmental malformations that underlie common congenital heart defects. In zebrafish, SHF progenitors produce half of the single ventricle's myocardium and contribute significantly to the OFT. Previous lineage tracing and mutant analyses suggested that SHF ventricular and OFT progenitors co-migrate to the arterial pole of the zebrafish heart tube soon after their specification in the nkx2...
October 23, 2017: Development
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