Emil Jørsboe, Mette K Andersen, Line Skotte, Frederik F Stæger, Nils J Færgeman, Kristian Hanghøj, Cindy G Santander, Ninna K Senftleber, Lars J Diaz, Maria Overvad, Ryan K Waples, Frank Geller, Peter Bjerregaard, Mads Melbye, Christina V L Larsen, Bjarke Feenstra, Anders Koch, Marit E Jørgensen, Niels Grarup, Ida Moltke, Anders Albrechtsen, Torben Hansen
The common Arctic-specific LDLR p.G137S variant was recently shown to be associated with elevated lipid levels. Motivated by this, we aimed to investigate the effect of p.G137S on metabolic health and cardiovascular disease risk among Greenlanders to quantify its impact on the population. In a population-based Greenlandic cohort (n = 5,063), we tested for associations between the p.G137S variant and metabolic health traits as well as cardiovascular disease risk based on registry data. In addition, we explored the variant's impact on plasma NMR measured lipoprotein concentration and composition in another Greenlandic cohort (n = 1,629); 29...
October 13, 2022: HGG advances