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https://www.readbyqxmd.com/read/28814776/continuously-wavelength-tunable-passband-flattened-fiber-comb-filter-based-on-polarization-diversified-loop-structure
#1
Jaehoon Jung, Yong Wook Lee
Continuous wavelength tuning of optical comb filters, which is an essential functionality for flexible signal processing in reconfigurable optical systems, has been challenging in high order filter structures with two birefringent elements (BEs) or more due to cumbersomeness in finding a combination of waveplates and BEs and complexity in determining their individual azimuthal orientations. Here, we propose a continuously tunable polarization-independent passband-flattened fiber comb filter with two BEs using a polarization-diversified loop structure for the first time...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28808761/the-underappreciated-risk-of-thrombosis-and-bleeding-in-patients-with-myelofibrosis-a-review
#2
REVIEW
Devendra Kc, Lorenzo Falchi, Srdan Verstovsek
Bleeding and thrombosis are long recognized complications of myelofibrosis (MF) and contribute significantly to its morbidity and mortality. However, so far, few studies have evaluated the frequency of these events, their characteristics, and their prognostic impact. Based on these studies, thrombotic events in MF are about as common as in essential thrombocytemia (ET) but less common than in polycythemia vera (PV), while bleeding events are relatively more common in MF than in ET or PV. The emergence of the concept of prefibrotic primary MF (PMF), which is associated with a higher frequency of thrombohemorrhagic complications than ET, and the growing evidence that prefibrotic PMF may also have a different thrombotic and bleeding risk profiles than fibrotic (overt) PMF have emphasized the need for a reappraisal of the risk of thrombosis and hemorrhage in patients with MF...
August 14, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28808100/hacking-the-thylakoid-proton-motive-force-for-improved-photosynthesis-modulating-ion-flux-rates-that-control-proton-motive-force-partitioning-into-%C3%AE-%C3%AF-and-%C3%AE-ph
#3
REVIEW
Geoffry A Davis, A William Rutherford, David M Kramer
There is considerable interest in improving plant productivity by altering the dynamic responses of photosynthesis in tune with natural conditions. This is exemplified by the 'energy-dependent' form of non-photochemical quenching (qE), the formation and decay of which can be considerably slower than natural light fluctuations, limiting photochemical yield. In addition, we recently reported that rapidly fluctuating light can produce field recombination-induced photodamage (FRIP), where large spikes in electric field across the thylakoid membrane (Δψ) induce photosystem II recombination reactions that produce damaging singlet oxygen ((1)O2)...
September 26, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28805224/molecular-dynamics-based-strength-estimates-of-beta-solenoid-proteins
#4
Amanda Parker, Krishnakumar Ravikumar, Daniel Cox
The use of beta solenoid proteins as functionalizable, nanoscale, self-assembling molecular building blocks may have many applications, including templating the growth of wires or higher-dimensional structures. By understanding their mechanical strengths, we can efficiently design the proteins for specific functions. We present a study of the mechanical properties of seven beta solenoid proteins using GROMACS molecular dynamics software to produce force/torque-displacement data, implement umbrella sampling of bending/twisting trajectories, produce Potentials of Mean Force (PMFs), extract effective spring constants, and calculate rigidities for two bending and two twisting directions for each protein...
August 14, 2017: Soft Matter
https://www.readbyqxmd.com/read/28799617/long-range-transport-clusters-and-positive-matrix-factorization-source-apportionment-for-investigating-transboundary-pm2-5-in-gothenburg-sweden
#5
Peter Molnár, Lin Tang, Karin Sjöberg, Janine Wichmann
Source apportionment studies of particulate matter are common and have been performed either as source region analyses using air mass back trajectories or by source type using source apportionment techniques. By combining the two approaches, it is possible to estimate the relative importance of emitters in different regions. PM2.5 samples were collected in Gothenburg between September 2008 and September 2009. The mean daily PM2.5 level was 6.1 μg m(-3) (range 0.79-30.91 μg m(-3)). Elemental analyses were done using Energy dispersive X-ray fluorescence (EDXRF) spectroscopy...
August 11, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28796943/forensic-analysis-of-polychlorinated-dibenzo-p-dioxin-and-furan-fingerprints-to-elucidate-dechlorination-pathways
#6
Lisa A Rodenburg, Yashika Dewani, Max M Haggblom, Lee Kerkhof, Donna E Fennell
Polychlorinated dibenzo-p-dioxins and -furans (PCDD/Fs) are persistent organic pollutants whose main removal process in the environment is due to biodegradation, and particularly anaerobic reductive dechlorination. Since PCDD/F congeners that are substituted in the lateral 2, 3, 7, and 8 positions are the most toxic, removal of these chlorines is advantageous, but previous studies have only demonstrated their removal under laboratory conditions. We evaluated a concentration data set of PCDD/F congeners with four or more chlorines along with all 209 polychlorinated biphenyl (PCB) congeners in surface water, treated and untreated wastewater, landfill leachate, and biosolids (NY CARP dataset) to determine whether peri and peri/lateral dechlorination of PCDD/Fs occurs in these environments...
August 10, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28794573/quantitative-assessment-of-pm2-5-sources-and-their-seasonal-variation-in-krakow
#7
Lucyna Samek, Z Stegowski, L Furman, K Styszko, K Szramowiat, J Fiedor
In industry areas of Poland such as Silesia or urban sites like Krakow and some other cities, the levels of pollutants frequently breach air quality standards. Particulate matter (PM) is the most important constituent of atmospheric pollution. Beginning on 1st February 2014 until 31st January 2015, the samples of fine particulate matter PM2.5 (aerodynamic diameter of particles less than or equal to 2.5 μm) were collected at a site in the south-eastern Krakow urban background area. During this period, 194 samples were taken...
2017: Water, Air, and Soil Pollution
https://www.readbyqxmd.com/read/28793207/divalent-ion-mediated-dna-dna-interactions-a%C3%A2-comparative-study-of-triplex-and-duplex
#8
Zhong-Liang Zhang, Yuan-Yan Wu, Kun Xi, Jian-Ping Sang, Zhi-Jie Tan
Ion-mediated interaction between DNAs is essential for DNA condensation, and it is generally believed that monovalent and nonspecifically binding divalent cations cannot induce the aggregation of double-stranded (ds) DNAs. Interestingly, recent experiments found that alkaline earth metal ions such as Mg(2+) can induce the aggregation of triple-stranded (ts) DNAs, although there is still a lack of deep understanding of the surprising findings at the microscopic level. In this work, we employed all-atom dynamic simulations to directly calculate the potentials of mean force (PMFs) between tsDNAs, between dsDNAs, and between tsDNA and dsDNA in Mg(2+) solutions...
August 8, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/28791032/the-role-of-light-dark-regulation-of-the-chloroplast-atp-synthase
#9
Kaori Kohzuma, John E Froehlich, Geoffry A Davis, Joshua A Temple, Deepika Minhas, Amit Dhingra, Jeffrey A Cruz, David M Kramer
The chloroplast ATP synthase catalyzes the light-driven synthesis of ATP and is activated in the light and inactivated in the dark by redox-modulation through the thioredoxin system. It has been proposed that this down-regulation is important for preventing wasteful hydrolysis of ATP in the dark. To test this proposal, we compared the effects of extended dark exposure in Arabidopsis lines expressing the wild-type and mutant forms of ATP synthase that are redox regulated or constitutively active. In contrast to the predictions of the model, we observed that plants with wild-type redox regulation lost photosynthetic capacity rapidly in darkness, whereas those expressing redox-insensitive form were far more stable...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28777534/poly-4-vinylphenol-pvp-and-poly-melamine-co-formaldehyde-pmf-based-atomic-switching-device-and-its-application-to-logic-gate-circuits-with-low-operating-voltage
#10
Dong-Ho Kang, Woo-Young Choi, Hyunsuk Woo, Sungkyu Jang, Hyung-Youl Park, Jaewoo Shim, Jae-Woong Choi, Sungho Kim, Sanghun Jeon, Sungjoo Lee, Jin-Hong Park
In this study, we demonstrate a high-performance solid polymer electrolyte (SPE) atomic switching device with low SET/RESET voltages (0.25 and -0.5 V, respectively), high on/off-current ratio (10(5)), excellent cyclic endurance (>10(3)), and long retention time (>10(4) s), where poly-4-vinylphenol (PVP)/poly(melamine-co-formaldehyde) (PMF) is used as an SPE layer. To accomplish these excellent device performance parameters, we reduce the off-current level of the PVP/PMF atomic switching device by improving the electrical insulating property of the PVP/PMF electrolyte through adjustment of the number of cross-linked chains...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28775247/spinal-abscess-caused-by-salmonella-bacteremia-in-a-patient-with-primary-myelofibrosis
#11
Shehab Fareed, Abdulqadir J Nashwan, Sulieman Abu Jarir, Ahmed Husain, Dina Sameh Suliman, Friyal Ibrahim, Abbas Moustafa, Muhammad S Akhter, Mohamed A Yassin
BACKGROUND In Primary Myelofibrosis (PMF; a clonal disorder arising from the neoplastic transformation of early hematopoietic stem cells) patients, spinal cord compression (SCC) is a common complication or even a presentation symptom due to extramedullary hematopoiesis (EMH). However, a case of SCC caused by a spinal abscess is unusual. To the best of our knowledge, this is the first case report of this rare condition. CASE REPORT We are reporting the case of a 50-year-old male with primary myelofibrosis and long-standing splenomegaly with back pain as a presenting symptom who was found to have spinal cord compression...
August 4, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28774178/quantized-transport-strain-induced-perfectly-conducting-modes-and-valley-filtering-on-shape-optimized-graphene-corbino-devices
#12
Gareth W Jones, Dario Andres Bahamon, Antonio H Castro Neto, Vitor M Pereira
The extreme mechanical resilience of graphene and the peculiar coupling it hosts between lattice and electronic degrees of freedom have spawned a strong impetus toward strain-engineered graphene where, on the one hand, strain augments the richness of its phenomenology and makes possible new concepts for electronic devices, and on the other hand, new and extreme physics might take place. Here, we demonstrate that the shape of substrates supporting graphene sheets can be optimized for approachable experiments where strain-induced pseudomagnetic fields (PMF) can be tailored by pressure for directionally selective electronic transmission and pinching-off of current flow down to the quantum channel limit...
August 9, 2017: Nano Letters
https://www.readbyqxmd.com/read/28770949/treatment-of-patients-with-primary-myelofibrosis-using-dasatinib
#13
Q-L Song, B Zhang, Y Xu, R-X Xia, X-H Lu, Z-X Pei, Q-W Xu, W-Y Li, Z-D Li
OBJECTIVE: Primary myelofibrosis (PMF) is a chronic clonal myeloproliferative neoplasm. It is associated with a poor prognosis, with a median survival time of approximately five years. Thus far, there are no specific targeted drugs for PMF. In this study, we evaluated the efficacy and safety of dasatinib, a second-generation tyrosine kinase inhibitor, in six PMF patients. PATIENTS AND METHODS: From June 1, 2015 to February 29, 2016, six patients with PMF in our department were enrolled into this trial...
July 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28766534/-clinical-features-of-essential-thrombocythemia-and-primary-myelofibrosis-depending-on-the-molecular-characteristics-of-disease
#14
A L Melikyan, I N Subortseva, A B Sudarikov, A M Kovrigina, E A Gilyazitdinova, T I Kolosheinova, A O Abdullaev, S A Treglazova
The aim of the present paper was to evaluate the clinical features and risk of thrombotic events (TE) in patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF), depending on the molecular characteristics of disease. Clinical data and laboratory parameters were analyzed in 50 ET patients and 50 PMF ones who had been followed up at the Department for Standardization of Treatments, National Research Center for Hematology, Ministry of Health of the Russian Federation, from February 2015 to September 2016...
2017: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/28763655/improved-source-apportionment-of-pahs-and-pb-by-integrating-pb-stable-isotopes-and-positive-matrix-factorization-application-pahs-a-historical-record-case-study-from-the-northern-south-china-sea
#15
Minggang Cai, Yan Lin, Meng Chen, Weifeng Yang, Huihong Du, Ye Xu, Shayen Cheng, Fangjian Xu, Jiajun Hong, Mian Chen, Hongwei Ke
To obtain the historical changes of pyrogenic sources, integrated source apportionment methods, which include PAH compositions, diagnostic ratios (DRs), Pb isotopic ratios, and positive matrix factorization (PMF) model, were developed and applied in sediments of the northern South China Sea. These methods provided a gradually clear picture of energy structural change. Spatially, Σ15PAH (11.3 to 95.5ng/g) and Pb (10.2 to 74.6μg/g) generally exhibited decreasing concentration gradient offshore; while the highest levels of PAHs and Pb were observed near the southern Taiwan Strait, which may be induced by accumulation of different fluvial input...
July 27, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28745329/involvement-of-maf-spp1-axis-in-the-development-of-bone-marrow-fibrosis-in-pmf-patients
#16
S Ruberti, E Bianchi, P Guglielmelli, S Rontauroli, G Barbieri, L Tavernari, T Fanelli, R Norfo, V Pennucci, G C Fattori, C Mannarelli, N Bartalucci, B Mora, L Elli, M A Avanzini, C Rossi, S Salmoiraghi, R Zini, S Salati, Z Prudente, V Rosti, F Passamonti, A Rambaldi, S Ferrari, E Tagliafico, A M Vannucchi, R Manfredini
Primary Myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by hyperplastic megakaryopoiesis and myelofibrosis. We recently described the upregulation of MAF in PMF CD34+ hematopoietic progenitor cells (HPCs) compared to healthy donor. Here we demonstrated that MAF is also upregulated in PMF compared to Essential Thrombocytemia (ET) and Polycytemia Vera (PV) HPCs. MAF overexpression and knockdown experiments shed some light into the role of MAF in PMF pathogenesis, by demonstrating that MAF favours the megakaryocyte and monocyte/macrophage commitment of HPCs and leads to the increased expression of proinflammatory and profibrotic mediators...
July 12, 2017: Leukemia: Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K
https://www.readbyqxmd.com/read/28737134/nephrotic-syndrome-in-primary-myelofibrosis-with-renal-extramedullary-hematopoiesis-and-glomerulopathy-in-the-jak-inhibitor-era
#17
Rachele Del Sordo, Rachele Brugnano, Carla Covarelli, Gioia Fiorucci, Franca Falzetti, Giorgio Barbatelli, Emidio Nunzi, Angelo Sidoni
Primary myelofibrosis (PMF) is an uncommon form of myeloproliferative neoplasm (MPN) characterized by a proliferation of predominantly megakaryocytes and granulocytes in the bone marrow that, in fully-developed disease, is associated with reactive deposition of fibrous connective tissue, extramedullary hematopoiesis (EMH), and splenomegaly. Kidney involvement is rare and clinically presents with proteinuria, nephrotic syndrome, and renal insufficiency. Renal damage can be due to EMH and glomerulopathy. Renal EMH presents three patterns: infiltration of the interstitium with possible renal failure caused by functional damage of parenchyma and vessels, infiltration of capsule and pericapsular adipose tissue, and sclerosing mass-like lesions that can cause hydronephrosis and hydroureter with obstructive uropathy and renal failure...
July 24, 2017: Clinical Nephrology
https://www.readbyqxmd.com/read/28731851/the-frequency-of-occurrence-of-fish-shaped-red-blood-cells-in-different-haematologic-disorders
#18
Christoph Robier, Carolin Körber, Franz Quehenberger, Manfred Neubauer, Albert Wölfler
BACKGROUND: Red blood cells (RBC) resembling the silhouette of a fish are rarely observed in peripheral blood (PB) smears. In this study, we determined the frequency of occurrence of fish-shaped RBC in different haematologic diseases. METHODS: We examined PB smears of patients with iron deficiency anaemia (IDA) (n=23), β-thalassaemia minor (BTM) (n=30), sickle cell disease (SCD) (n=7), autoimmune haemolytic anaemia (AIHA) (n=13), microangiopathic haemolytic anaemia (MAHA) (n=11), hereditary sphaerocytosis (HS) (n=4), hereditary elliptocytosis (HE) (n=3), vitamin B12 and folate deficiency (n=15), anaemia in liver disease (LD) (n=17), myelodysplastic syndrome (MDS) (n=15), acute myeloid leukaemia (AML) (n=29), chronic myeloid leukaemia (CML) (n=18), primary myelofibrosis (PMF) (n=12), chronic myelo-monocytic leukaemia (CMML) (n=15) and 21 healthy controls by light microscopy for the occurrence of fish-shaped erythrocytes...
July 21, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28728535/endovascular-occlusion-of-pial-arteriovenous-macrofistulae-using-pcanvas1-and-adenosine-induced-asystole-to-control-nbca-injection
#19
P Lylyk, J Chudyk, C Bleise, C Serna Candel, M Aguilar Pérez, H Henkes
Background In large-caliber pial macrofistulae (pMF), the combination of high blood flow velocity and large efferent artery diameter makes control over the endovascular vessel occlusion difficult and may result in the inadvertent venous passage of occlusive devices or embolic agents. Case descriptions Patient 1: A 27-year-old man presented with headache and ataxia. An infratentorial pMF supplied by both superior cerebellar arteries with venous ectasia was found. The first treatment attempt using balloons and coils failed since the position of either device could not be controlled because of a distal diameter of the feeding artery of 8 mm...
January 1, 2017: Interventional Neuroradiology
https://www.readbyqxmd.com/read/28711569/the-influence-of-land-use-on-source-apportionment-and-risk-assessment-of-polycyclic-aromatic-hydrocarbons-in-road-deposited-sediment
#20
Jin Zhang, Junwei Wu, Pei Hua, Zhonghua Zhao, Lei Wu, Gongduan Fan, Yun Bai, Thomas Kaeseberg, Peter Krebs
The pollution load of urban runoff is boosted due to the washing away of road-deposited sediment (RDS). Therefore, a source-oriented mitigation strategy is essential to integrated stormwater management. This study showcases the influence of land use dependent source apportionment and risk assessment of polycyclic aromatic hydrocarbons (PAHs) in RDS. Samples were collected from areas of different land uses, including commercial city centre, highway, residential rural and campus areas. According to the positive matrix factorisation (PMF) receptor model, different primary sources were identified at different land use areas...
July 13, 2017: Environmental Pollution
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