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https://www.readbyqxmd.com/read/28432892/arsenic-chromium-molybdenum-and-selenium-geochemical-fractions-and-potential-mobilization-in-riverine-soil-profiles-originating-from-germany-and-egypt
#1
Sabry M Shaheen, Eilhann E Kwon, Jayanta K Biswas, Filip M G Tack, Yong Sik Ok, Jörg Rinklebe
The fractionation and potential mobilization of As, Cr, Mo, and Se in four floodplain soil profiles collected along the Nile (Egypt) and Wupper (Germany) Rivers were assessed using the BCR sequential extraction procedure. The concentrations of total and the geochemical fractions (acid soluble (F1), reducible (F2), oxidizable (F3), and residual (F4) fraction) of the elements were determined. The Wupper soils had the highest total concentrations (mg kg(-1)) of As (378) and Cr (2,797) while the Nile soils contained the highest total Mo (12) and Se (42)...
April 14, 2017: Chemosphere
https://www.readbyqxmd.com/read/28426975/the-regulation-of-the-chloroplast-proton-motive-force-plays-a-key-role-for-photosynthesis-in-fluctuating-light
#2
REVIEW
Ute Armbruster, Viviana Correa Galvis, Hans-Henning Kunz, Deserah D Strand
Plants use sunlight as their primary energy source. During photosynthesis, absorbed light energy generates reducing power by driving electron transfer reactions. These are coupled to the transfer of protons into the thylakoid lumen, generating a proton motive force (pmf) required for ATP synthesis. Sudden alterations in light availability have to be met by regulatory mechanisms to avoid the over-accumulation of reactive intermediates and maximize energy efficiency. Here, the acidification of the lumen, as an intermediate product of photosynthesis, plays an important role by regulating photosynthesis in response to excitation energy levels...
April 17, 2017: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/28423484/mir-494-3p-overexpression-promotes-megakaryocytopoiesis-in-primary-myelofibrosis-hematopoietic-stem-progenitor-cells-by-targeting-socs6
#3
Sebastiano Rontauroli, Ruggiero Norfo, Valentina Pennucci, Roberta Zini, Samantha Ruberti, Elisa Bianchi, Simona Salati, Zelia Prudente, Chiara Rossi, Vittorio Rosti, Paola Guglielmelli, Giovanni Barosi, Alessandro Vannucchi, Enrico Tagliafico, Rossella Manfredini
Primary myelofibrosis (PMF) is a chronic Philadelphia-negative myeloproliferative neoplasm characterized by hematopoietic stem cell-derived clonal myeloproliferation, involving especially the megakaryocyte lineage. To better characterize how the altered expression of microRNAs might contribute to PMF pathogenesis, we have previously performed the integrative analysis of gene and microRNA expression profiles of PMF hematopoietic stem/progenitor cells (HSPCs), which allowed us to identify miR-494-3p as the upregulated microRNA predicted to target the highest number of downregulated mRNAs...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422716/sequential-evaluation-of-calr-mutant-burden-in-patients-with-myeloproliferative-neoplasms
#4
Chiara Cavalloni, Elisa Rumi, Virginia V Ferretti, Daniela Pietra, Elisa Roncoroni, Marta Bellini, Michele Ciboddo, Ilaria C Casetti, Benedetta Landini, Elena Fugazza, Daniela Troletti, Cesare Astori, Mario Cazzola
We investigated the variation of CALR-mutant burden during follow-up in 105 CALR-mutant MPN and compared it to the variation of JAK2-mutant burden in 226 JAK2-mutant MPN.The median allele burden at last evaluation was significantly higher than at first evaluation in essential thrombocythemia (ET) (49.5% vs 45%, P < .001) but not in primary myelofibrosis (PMF) (52% vs 51%, P 0.398). Median values of slope were positive both in ET (0.071) and in PMF (0.032). In CALR-mutant ET there was a difference between natural and therapy-related slope (P 0...
April 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422503/predicting-protein-interactions-of-concentrated-globular-protein-solutions-using-colloidal-models
#5
Mahlet Asfaw Woldeyes, Cesar Calero-Rubio, Eric M Furst, Christopher J Roberts
Protein interactions of α-chymotrypsinogen A (aCgn) were quantified using light scattering from low to high protein concentrations. Static light scattering (SLS) was used to determine the excess Rayleigh ratio (R(ex)) and osmotic second virial coefficients (B22) as a function of pH and total ionic strength (TIS). Repulsive (attractive) protein-protein interactions (PPI) were observed at pH 5 (pH 7), with decreasing repulsions (attractions) upon increasing TIS. Simple colloidal potential-of-mean force models (PMF) that account for short-range non-electrostatic attractions and screened electrostatic interactions were used to fit model parameters from data for B22 vs TIS at both pH values...
April 19, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28421043/outlining-core-pathways-of-amyloid-toxicity-in-bacteria-with-the-repa-wh1-prionoid
#6
Laura Molina-García, María Moreno-Del Álamo, Pedro Botias, Zaira Martín-Moldes, María Fernández, Alicia Sánchez-Gorostiaga, Aída Alonso-Del Valle, Juan Nogales, Jesús García-Cantalejo, Rafael Giraldo
The synthetic bacterial prionoid RepA-WH1 causes a vertically transmissible amyloid proteinopathy in Escherichia coli that inhibits growth and eventually kills the cells. Recent in vitro studies show that RepA-WH1 builds pores through model lipid membranes, suggesting a possible mechanism for bacterial cell death. By comparing acutely (A31V) and mildly (ΔN37) cytotoxic mutant variants of the protein, we report here that RepA-WH1(A31V) expression decreases the intracellular osmotic pressure and compromise bacterial viability under either aerobic or anaerobic conditions...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28419183/comparison-of-the-mutational-profiles-of-primary-myelofibrosis-polycythemia-vera-and-essential-thrombocytosis
#7
Jinming Song, Mohammad Hussaini, Hailing Zhang, Haipeng Shao, Dahui Qin, Xiaohui Zhang, Zhenjun Ma, Syeda Mahrukh Hussnain Naqvi, Ling Zhang, Lynn C Moscinski
Objectives: To compare the mutational profiles of patients with primary myelofibrosis (PMF), polycythemia vera (PV), and essential thrombocytosis (ET). Methods: Next-generation sequencing results of 75 cases of PMF, 33 cases of PV, and 27 cases of ET were compared. Results: Mutation rates of ASXL1 and SRSF2 were significantly higher in PMF than in PV or ET. ASXL1 mutations appeared to be more frequently associated with risk of transformation to acute myeloid leukemia than JAK2 or TET2 mutations...
April 15, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28417976/revealing-inhibition-difference-between-pfi-2-enantiomers-against-setd7-by-molecular-dynamics-simulations-binding-free-energy-calculations-and-unbinding-pathway-analysis
#8
Yuzhen Niu, Danfeng Shi, Lanlan Li, Jingyun Guo, Huanxiang Liu, Xiaojun Yao
SETD7 is associated with multiple diseases related signaling pathways. (R)-PFI-2 is the first SETD7 inhibitor with nanomolar inhibitory potency. The activity of (R)-PFI-2 is about 500 times over that of (S)-PFI-2. Understanding the mechanism behind this difference will be helpful to discovery and design of more potent SETD7 inhibitors. A computational study combining molecular dynamics simulation, binding free energy calculations, and residue interaction network (RIN) was performed on the (S)-PFI-2/SETD7 and (R)-PFI-2/SETD7 complexes to explore the molecular mechanism behind the different inhibition activity...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28414753/sustained-low-peritoneal-effluent-ccl18-levels-are-associated-with-preservation-of-peritoneal-membrane-function-in-peritoneal-dialysis
#9
Marta Ossorio, María Auxiliadora Bajo, Gloria Del Peso, Virginia Martínez, María Fernández, María José Castro, Aranzazu Rodríguez-Sanz, Rosario Madero, Teresa Bellón, Rafael Selgas
Peritoneal membrane failure (PMF) and, ultimately, encapsulating peritoneal sclerosis (EPS) are the most serious peritoneal dialysis (PD) complications. Combining clinical and peritoneal transport data with the measurement of molecular biomarkers, such as the chemokine CCL18, would improve the complex diagnosis and management of PMF. We measured CCL18 levels in 43 patients' effluent and serum at baseline and after 1, 2, and 3 years of PD treatment by retrospective longitudinal study, and evaluated their association with PMF/EPS development and peritoneal risk factors...
2017: PloS One
https://www.readbyqxmd.com/read/28412487/occurrence-homologue-patterns-and-source-apportionment-of-short-%C3%A2-and-medium-chain-chlorinated-paraffins-in-suburban-soils-of-shanghai-china
#10
Xue-Tong Wang, Si-Yue Xu, Xi-Kui Wang, Bao-Ping Hu, Hao-Hao Jia
In order to systematically investigate the spatial distribution, homologue profiles, and sources of short- and medium-chain chlorinated paraffins (SCCPs and MCCPs) in suburban soils in Shanghai, SCCPs and MCCPs in soils were analyzed using gas chromatography coupled with low resolution mass spectrometry in electron capture negative ion (ECNI) mode (GC-ECNI-MS). The CP concentrations in soils were between not detected (ND) - 697 ng g(-1) with a median value of 3.52 ng g(-1) for SCCPs, and ND - 666 ng g(-1) with a median value of 15...
April 9, 2017: Chemosphere
https://www.readbyqxmd.com/read/28412402/flavonoid-composition-of-orange-peel-extract-ameliorates-alcohol-induced-tight-junction-dysfunction-in-caco-2-monolayer
#11
Xiu-Min Chen, David D Kitts
Dry citrus peels, also known as "chenpi", have been traditionally used to treat and relieve intestinal inflammation. Recently we have reported that orange peel extracts (OPE) which contain relatively greater polymethoxylated flavone (PMF) content exhibit superior antioxidant and anti-inflammatory activities in vitro. Moreover, these bioactivities were notably greater than an equivalent flavonoid mixture (FM). The present study compares the effects of different OPE sources with distinct PMF composition on tight junction (TJ) dysfunction induced by ethanol...
April 12, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28411566/ambient-fine-particulate-matter-pm2-5-in-canadian-oil-sands-communities-levels-sources-and-potential-human-health-risk
#12
Md Aynul Bari, Warren B Kindzierski
An investigation of levels and potential sources affecting ambient fine particulate matter (PM2.5) and associated risk to public health was undertaken at two Canadian oil sands communities (Fort McKay and Fort McMurray) using a 4-year dataset (2010-2013). Geometric mean concentrations of PM2.5 at Fort McKay and Fort McMurray are not considered high and were 5.47μg/m(3) (interquartile range, IQR=3.02-8.55μg/m(3)) and 4.96μg/m(3) (IQR=3.20-7.04μg/m(3)), respectively. Carcinogenic risks of trace elements were below acceptable (1×10(-6)) and/or within tolerable risk (1×10(-4)), and non-carcinogenic risks were below a safe level of concern (hazard index=1)...
April 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28411309/calreticulin-mutations-in-bulgarian-mpn-patients
#13
Ivan Pavlov, Evgueniy Hadjiev, Tzvetan Alaikov, Sylva Spassova, Angel Stoimenov, Elissaveta Naumova, Velizar Shivarov, Milena Ivanova
Somatic mutations in JAK2, MPL and CALR are recurrently identified in most of the cases with Philadelphia chromosome negative myeloproliferative neoplasms (MPNs). We applied four molecular genetic methods for identification of CALR exon 9 mutations, including high resolution melt (HRM) analysis, Sanger sequencing, semiconductor target genes sequencing and whole exome sequencing. A total of 78 patients with myeloid malignancies were included in the study. We identified 14 CALR exon 9 mutated cases out of 78 studied patients with myeloid malignancies...
April 14, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28409936/visualizing-strain-induced-pseudomagnetic-fields-in-graphene-through-an-hbn-magnifying-glass
#14
Yuhang Jiang, Jinhai Mao, Junxi Duan, Xinyuan Lai, Kenji Watanabe, Takashi Taniguchi, Eva Y Andrei
Graphene's remarkable properties are inherent to its two-dimensional honeycomb lattice structure. Its low dimensionality, which makes it possible to rearrange the atoms by applying an external force, offers the intriguing prospect of mechanically controlling the electronic properties. In the presence of strain, graphene develops a pseudomagnetic field (PMF) that reconstructs the band structure into pseudo Landau levels (PLLs). However, a feasible route to realizing, characterizing and controlling PMFs is still lacking...
April 24, 2017: Nano Letters
https://www.readbyqxmd.com/read/28409218/transmembrane-helices-containing-a-charged-arginine-are-thermodynamically-stable
#15
Martin B Ulmschneider, Jakob P Ulmschneider, J Alfredo Freites, Gunnar von Heijne, Douglas J Tobias, Stephen H White
Hydrophobic amino acids are abundant in transmembrane (TM) helices of membrane proteins. Charged residues are sparse, apparently due to the unfavorable energetic cost of partitioning charges into nonpolar phases. Nevertheless, conserved arginine residues within TM helices regulate vital functions, such as ion channel voltage gating and integrin receptor inactivation. The energetic cost of arginine in various positions along hydrophobic helices has been controversial. Potential of mean force (PMF) calculations from atomistic molecular dynamics simulations predict very large energetic penalties, while in vitro experiments with Sec61 translocons indicate much smaller penalties, even for arginine in the center of hydrophobic TM helices...
April 13, 2017: European Biophysics Journal: EBJ
https://www.readbyqxmd.com/read/28408654/radiographic-disease-progression-in-contemporary-us-coal-miners-with-progressive-massive-fibrosis
#16
A Scott Laney, David John Blackley, Cara N Halldin
INTRODUCTION: Among contemporary US coal miners, there has been an increase in the prevalence and severity of pneumoconiosis, including its advanced form progressive massive fibrosis (PMF). We examine radiographic progression in Coal Workers' Health Surveillance Program (CWHSP) participants. METHODS: CWHSP participants with a final determination of PMF during 1 January 2000-1 October 2016 with at least one prior radiograph in the system were included. We characterised demographics, participation and progression patterns...
April 13, 2017: Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/28391918/typical-atmospheric-haze-during-crop-harvest-season-in-northeastern-china-a-case-in-the-changchun-region
#17
WeiWei Chen, Daniel Q Tong, Mo Dan, ShiChun Zhang, XueLei Zhang, YuePeng Pan
This study presents the mass concentrations of PM2.5, O3, SO2 and NOx at one urban, one suburban and two rural locations in the Changchun region from September 25 to October 27 2013. Major chemical components of PM2.5 at the four sites were daily sampled and analyzed. Most of daily concentrations of SO2 (7-82μg/m(3)), O3 (27-171μg/m(3)) and NOx (14-213μg/m(3)) were below the limits of the National Ambient Air Quality Standard (NAAQS) in China. However, PM2.5 concentrations (143-168μg/m(3)) were 2-fold higher than NAAQS...
April 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28389941/fuel-of-the-bacterial-flagellar-type-iii-protein-export-apparatus
#18
Tohru Minamino, Miki Kinoshita, Keiichi Namba
The flagellar type III export apparatus utilizes ATP and proton motive force (PMF) across the cytoplasmic membrane as the energy sources and transports flagellar component proteins from the cytoplasm to the distal growing end of the growing structure to construct the bacterial flagellum beyond the cellular membranes. The flagellar type III export apparatus coordinates flagellar protein export with assembly by ordered export of substrates to parallel with their order of the assembly. The export apparatus is composed of a PMF-driven transmembrane export gate complex and a cytoplasmic ATPase complex...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28383153/silver-potentiates-aminoglycoside-toxicity-by-enhancing-their-uptake
#19
Marion Herisse, Yohann Duverger, Isabelle Martin-Verstraete, Frédéric Barras, Benjamin Ezraty
The predicted shortage in new antibiotics has prompted research for chemicals that could act as adjuvant and enhance efficacy of available antibiotics. In this study, we tested the effects of combining metals with aminoglycosides on Escherichia coli survival. The best synergising combination resulted from mixing aminoglycosides with silver. Using genetic and aminoglycoside uptake assays, we showed that silver potentiates aminoglycoside action in by-passing the PMF-dependent step, but depended upon protein translation...
April 6, 2017: Molecular Microbiology
https://www.readbyqxmd.com/read/28381690/18f-fdg-pet-ct-is-effective-in-distinguishing-myelofibrosis-due-to-bone-marrow-infiltration-of-diffuse-large-b-cell-lymphoma-from-triple-negative-primary-myelofibrosis
#20
Takuma Kumagai, Yoko Satoh, Megumi Koshiishi, Saori Ooishi, Yuki Sueki, Kei Nakajima, Toru Mitsumori, Keita Kirito
Although myelofibrosis is mainly associated with myeloproliferative neoplasms (MPN), especially primary myelofibrosis (PMF), a variety of hematological malignancies, including acute myeloid leukemia, multiple myeloma and malignant lymphoma, also cause myelofibrosis with markedly varying degrees of severity. Thus, it is extremely important to accurately diagnose the underlying diseases that cause fibrosis in bone marrow. Analyses of JAK2, MPL and calreticulin gene mutations are useful for distinguishing MPN from other diseases, since 90% of MPN patients have a mutation in one of these genes...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
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