keyword
MENU ▼
Read by QxMD icon Read
search

Pmf

keyword
https://www.readbyqxmd.com/read/28933279/zinc-transporter-protein-tzn-1-may-also-play-a-role-in-conidiation-pathway-of-neurospora-crassa-an-insight-using-proteogenomic-approachusing-proteogenomic-approach
#1
Divya Rupa Venkata Pandala, Jogeswar Gadi, Kiranmayi Patnala
Zinc transporter (tzn-1) of Neurospora crassa plays a crucial role in conidiation pathway, as its removal results in aconidiation which was reported in our earlier studies. Present study depicts the role of tzn-1 in conidiation process, by comparing knockout (KO) mutants zinc transporter KO (Δtzn-1) and aconidiating gene KO (Δacon-3) with wild oak ridge (OR) 74 'A' strain by 'Proteo-genomic' approach. Firstly, nine commonly overexpressed protein spots from the two sets (Δtzn-1 to wild and Δacon-3 to wild) were analyzed by combining 2-Dimensional gel electrophoresis (2DE) with Matrix Associated Laser Desorption/Ionization mass spectrometry -Peptide Mass Fingerprint (MALDI-PMF)...
September 19, 2017: Protein and Peptide Letters
https://www.readbyqxmd.com/read/28923752/anthropogenic-and-geogenic-mass-input-of-trace-elements-to-moss-and-natural-surface-soil-in-norway
#2
Erik R Christensen, Eiliv Steinnes, Ola Anfin Eggen
Data sets for concentrations of up to 22 elements including Pb, Cd, Ag, As, and Hg and several rare earth elements (REEs) in moss and surface soil from all over mainland Norway are analyzed by positive matrix factorization (PMF) and principal component analysis (PCA) with centered log-ratio transformation. Moss and soil samples collected in 2010 and 2005, respectively, show both a distinct long-range atmospheric transport PMF factor including a dominant Pb loading along with smaller loadings of Mo, Cd, Sb, and As, and a geogenic factor dominated by Ce, La, and Y...
September 15, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28923340/seasonal-variation-spatial-distribution-and-source-apportionment-for-polycyclic-aromatic-hydrocarbons-pahs-at-nineteen-communities-in-xi-an-china-the-effects-of-suburban-scattered-emissions-in-winter
#3
Jingzhi Wang, Junji Cao, Zhibao Dong, Benjamin Guinot, Meiling Gao, Rujin Huang, Yongming Han, Yu Huang, Steven Sai Hang Ho, Zhenxing Shen
Seasonal variation and spatial distribution of PM2.5 bound polycyclic aromatic hydrocarbons (PAHs) were investigated at urban residential, commercial area, university, suburban region, and industry in Xi'an, during summer and winter time at 2013. Much higher levels of total PAHs were obtained in winter. Spatial distributions by kriging interpolations principle showed that relative high PAHs were detected in western Xi'an in both summer and winter, with decreasing trends in winter from the old city wall to the 2(nd)-3rd ring road except for the suburban region and industry...
September 15, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28911223/direct-sampling-and-analysis-of-atmospheric-particulate-organic-matter-by-proton-transfer-reaction-mass-spectrometry
#4
Markus Muller, Philipp Eichler, Barbara D'Anna, Wen Tan, Armin Wisthaler
We report on a new method for analyzing atmospheric submicrometer particulate organic matter which combines direct particle sampling and volatilization with on-line chemical ionization mass spectrometric analysis. Technically, the method relies on the combined use of a CHARON ("Chemical Analysis of Aerosol On-line") particle inlet and a proton-transfer-reaction time-of-flight mass spectrometer (PTR-ToF-MS). Laboratory studies on target analytes showed that the ionization conditions in the PTR-ToF-MS lead to extensive fragmentation of levoglucosan and cis-pinonic acid, while protonated oleic acid and 5-cholestane molecules remain intact...
September 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28906207/high-absolute-basophil-count-is-a-powerful-independent-predictor-of-inferior-overall-survival-in-patients-with-primary-myelofibrosis
#5
Marko Lucijanic, Ana Livun, Tajana Stoos-Veic, Vlatko Pejsa, Ozren Jaksic, David Cicic, Jelena Lucijanic, Zeljko Romic, Biserka Orehovec, Gorana Aralica, Marko Miletic, Rajko Kusec
OBJECTIVES: To investigate the clinical and prognostic significance of absolute basophil count (ABC) in patients with primary myelofibrosis (PMF). METHODS: We retrospectively investigated 58 patients with PMF treated in our institution in the period from 2006 to 2017. ABC was obtained in addition to other hematological and clinical parameters. Patients were separated into high and low ABC groups using the Receiver operating characteristic curve analysis. RESULTS: ABC was higher in PMF patients than in healthy controls (P < 0...
September 14, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/28905626/dna-assisted-dispersion-of-carbon-nanotubes-and-comparison-with-other-dispersing-agents
#6
Debabrata Pramanik, Prabal K K Maiti
Separation and sorting of pristine carbon nanotubes (CNTs) from bundle geometry is a very challenging task due to non-soluble and non-dispersive nature of CNTs in aqueous medium. Recently many studies have been performed to address this problem using various organic and inorganic solutions, surfactant molecules and biomolecules as dispersing agents. Recent experimental studies have reported the DNA to be highly efficient in dispersion of CNTs from bundle geometry. But there is no microscopic study and also quantitative estimation of the dispersion efficiency of the DNA...
September 14, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28903085/multiscale-molecular-dynamics-simulations-of-lipid-interactions-with-p-glycoprotein-in-a-complex-membrane
#7
Laura Domicevica, Heidi Koldsø, Philip C Biggin
P-glycoprotein (P-gp) can transport a wide range of very different hydrophobic organic molecules across the membrane. Its ability to extrude molecules from the cell creates delivery problems for drugs that target proteins in the central nervous system (CNS) and also causes drug-resistance in many forms of cancer. Whether a drug will be susceptible to export by P-gp is difficult to predict and currently this is usually assessed with empirical and/or animal models. Thus, there is a need to better understand how P-gp works at the molecular level in order to fulfil the 3Rs: Refinement, reduction and replacement of animals in research...
September 2, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28879468/source-contributions-to-total-concentrations-and-carcinogenic-potencies-of-polychlorinated-dibenzo-p-dioxins-and-polychlorinated-dibenzofurans-pcdd-fs-in-ambient-air-a-case-study-in-suzhou-city-china
#8
Zhiqiang Xuan, Chenglu Bi, Jiafu Li, Jihua Nie, Zhihai Chen
The potential source categories and source contributions of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) in ambient air from Suzhou City, China, were performed by principal component analysis-multiple linear regression (PCA-MLR) and positive matrix factorization (PMF). The carcinogenic potencies of PCDD/Fs were quantitatively apportioned based on the positive matrix factorization-toxic equivalent concentration (PMF-TEQ) method. The results of the present study were summarized as follows...
September 6, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28878221/combining-positive-matrix-factorization-and-radiocarbon-measurements-for-source-apportionment-of-pm2-5-from-a-national-background-site-in-north-china
#9
Xiaoping Wang, Zheng Zong, Chongguo Tian, Yingjun Chen, Chunling Luo, Jun Li, Gan Zhang, Yongming Luo
To explore the utility of combining positive matrix factorization (PMF) with radiocarbon ((14)C) measurements for source apportionment, we applied PM2.5 data collected for 14 months at a national background station in North China to PMF models. The solutions were compared to (14)C results of four seasonally averaged samples and three outlier samples. Comparing the most readily interpretable PMF solutions and (14)C results revealed that PMF modeling was well able to capture the source patterns of PM2.5 with two and three irrelevant source classifications for the seasonal and outlier samples...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28855298/spinal-bdnf-induced-phrenic-motor-facilitation-requires-pkc%C3%AE-activity
#10
Ibis M Agosto-Marlin, Gordon S Mitchell
Spinal brain derived neurotrophic factor (BDNF) is necessary and sufficient to elicit certain forms of long-lasting phrenic motor facilitation (pMF). BDNF elicits pMF by binding to its high affinity receptor tropomyosin receptor kinase B (TrkB), potentially activating multiple downstream signaling cascades. Canonical BDNF/TrkB signaling includes three pathways: 1) the Ras/RAF/MEK/ERK MAP Kinase pathway; 2) the phosphatidylinositol 3-kinase/Akt pathway; and 3) the PLCγ/PKC pathway. Here, we demonstrate that spinal BDNF-induced pMF requires PLCγ/PKCθ in normal rats, but not MEK/ERK or PI3K/Akt signaling...
August 30, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28837409/use-of-a-gc-ms-organic-aerosol-monitor-for-in-field-detection-of-fine-particulate-organic-compounds-in-source-apportionment
#11
Paul M Cropper, Delbert J Eatough, Devon K Overson, Jaron C Hansen, Fern Caka, Robert A Cary
A study was conducted on the Brigham Young University campus during January and February 2015 to identify winter-time sources of fine particulate material in Utah Valley, Utah. Fine particulate mass and components and related gas phase species were all measured on an hourly average basis. Light scattering was also measured during the study. Included in the sampling was the first-time source apportionment application of a new monitoring instrument for the measurement of fine particulate organic marker compounds on an hourly average basis...
August 24, 2017: Journal of the Air & Waste Management Association
https://www.readbyqxmd.com/read/28833510/a-new-method-to-quantify-the-health-risks-from-sources-of-perfluoroalkyl-substances-combined-with-pmf-and-risk-assessment-models
#12
Jiao Xu, Guo-Liang Shia, Chang-Sheng Guo, Hai-Ting Wang, Ying-Ze Tian, Yan-Qi Huangfu, Yuan Zhang, Yin-Chang Feng, Jian Xu
A hybrid model based on Positive Matrix Factorization (PMF) and Health Risk Assessment Model for assessing risks associated with sources of perfluoroalkyl substances (PFASs) in water was for the first time established, and applied at Dianchi Lake to test its applicability. The new method contains two stages: (1) The sources to PFASs were apportioned by PMF model and (2) the contribution of health risks from each source was calculated by the new hybrid model. Two factors were extracted by PMF, with Factor 1 identified as aqueous fire-fighting foams (AFFFs) source, and Factor 2 as fluoropolymer (FP) manufacturing and processing & perfluorooctanoic acid production source...
August 18, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/28814776/continuously-wavelength-tunable-passband-flattened-fiber-comb-filter-based-on-polarization-diversified-loop-structure
#13
Jaehoon Jung, Yong Wook Lee
Continuous wavelength tuning of optical comb filters, which is an essential functionality for flexible signal processing in reconfigurable optical systems, has been challenging in high order filter structures with two birefringent elements (BEs) or more due to cumbersomeness in finding a combination of waveplates and BEs and complexity in determining their individual azimuthal orientations. Here, we propose a continuously tunable polarization-independent passband-flattened fiber comb filter with two BEs using a polarization-diversified loop structure for the first time...
August 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28808761/the-underappreciated-risk-of-thrombosis-and-bleeding-in-patients-with-myelofibrosis-a-review
#14
REVIEW
Devendra Kc, Lorenzo Falchi, Srdan Verstovsek
Bleeding and thrombosis are long recognized complications of myelofibrosis (MF) and contribute significantly to its morbidity and mortality. However, so far, few studies have evaluated the frequency of these events, their characteristics, and their prognostic impact. Based on these studies, thrombotic events in MF are about as common as in essential thrombocytemia (ET) but less common than in polycythemia vera (PV), while bleeding events are relatively more common in MF than in ET or PV. The emergence of the concept of prefibrotic primary MF (PMF), which is associated with a higher frequency of thrombohemorrhagic complications than ET, and the growing evidence that prefibrotic PMF may also have a different thrombotic and bleeding risk profiles than fibrotic (overt) PMF have emphasized the need for a reappraisal of the risk of thrombosis and hemorrhage in patients with MF...
August 14, 2017: Annals of Hematology
https://www.readbyqxmd.com/read/28808100/hacking-the-thylakoid-proton-motive-force-for-improved-photosynthesis-modulating-ion-flux-rates-that-control-proton-motive-force-partitioning-into-%C3%AE-%C3%AF-and-%C3%AE-ph
#15
REVIEW
Geoffry A Davis, A William Rutherford, David M Kramer
There is considerable interest in improving plant productivity by altering the dynamic responses of photosynthesis in tune with natural conditions. This is exemplified by the 'energy-dependent' form of non-photochemical quenching (qE), the formation and decay of which can be considerably slower than natural light fluctuations, limiting photochemical yield. In addition, we recently reported that rapidly fluctuating light can produce field recombination-induced photodamage (FRIP), where large spikes in electric field across the thylakoid membrane (Δψ) induce photosystem II recombination reactions that produce damaging singlet oxygen ((1)O2)...
September 26, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28805224/molecular-dynamics-based-strength-estimates-of-beta-solenoid-proteins
#16
Amanda Parker, Krishnakumar Ravikumar, Daniel Cox
The use of beta solenoid proteins as functionalizable, nanoscale, self-assembling molecular building blocks may have many applications, including templating the growth of wires or higher-dimensional structures. By understanding their mechanical strengths, we can efficiently design the proteins for specific functions. We present a study of the mechanical properties of seven beta solenoid proteins using GROMACS molecular dynamics software to produce force/torque-displacement data, implement umbrella sampling of bending/twisting trajectories, produce Potentials of Mean Force (PMFs), extract effective spring constants, and calculate rigidities for two bending and two twisting directions for each protein...
September 20, 2017: Soft Matter
https://www.readbyqxmd.com/read/28799617/long-range-transport-clusters-and-positive-matrix-factorization-source-apportionment-for-investigating-transboundary-pm2-5-in-gothenburg-sweden
#17
Peter Molnár, Lin Tang, Karin Sjöberg, Janine Wichmann
Source apportionment studies of particulate matter are common and have been performed either as source region analyses using air mass back trajectories or by source type using source apportionment techniques. By combining the two approaches, it is possible to estimate the relative importance of emitters in different regions. PM2.5 samples were collected in Gothenburg between September 2008 and September 2009. The mean daily PM2.5 level was 6.1 μg m(-3) (range 0.79-30.91 μg m(-3)). Elemental analyses were done using Energy dispersive X-ray fluorescence (EDXRF) spectroscopy...
August 11, 2017: Environmental Science. Processes & Impacts
https://www.readbyqxmd.com/read/28796943/forensic-analysis-of-polychlorinated-dibenzo-p-dioxin-and-furan-fingerprints-to-elucidate-dechlorination-pathways
#18
Lisa A Rodenburg, Yashika Dewani, Max M Häggblom, Lee J Kerkhof, Donna E Fennell
Polychlorinated dibenzo-p-dioxins and -furans (PCDD/Fs) are persistent organic pollutants whose main removal process in the environment is due to biodegradation, and particularly anaerobic reductive dechlorination. Since PCDD/F congeners that are substituted in the lateral 2, 3, 7, and 8 positions are the most toxic, removal of these chlorines is advantageous, but previous studies have only demonstrated their removal under laboratory conditions. We evaluated a concentration data set of PCDD/F congeners with four or more chlorines along with all 209 polychlorinated biphenyl (PCB) congeners in surface water, treated and untreated wastewater, landfill leachate, and biosolids (NY CARP data set) to determine whether peri and peri/lateral dechlorination of PCDD/Fs occurs in these environments...
August 30, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28794573/quantitative-assessment-of-pm2-5-sources-and-their-seasonal-variation-in-krakow
#19
Lucyna Samek, Z Stegowski, L Furman, K Styszko, K Szramowiat, J Fiedor
In industry areas of Poland such as Silesia or urban sites like Krakow and some other cities, the levels of pollutants frequently breach air quality standards. Particulate matter (PM) is the most important constituent of atmospheric pollution. Beginning on 1st February 2014 until 31st January 2015, the samples of fine particulate matter PM2.5 (aerodynamic diameter of particles less than or equal to 2.5 μm) were collected at a site in the south-eastern Krakow urban background area. During this period, 194 samples were taken...
2017: Water, Air, and Soil Pollution
https://www.readbyqxmd.com/read/28793207/divalent-ion-mediated-dna-dna-interactions-a%C3%A2-comparative-study-of-triplex-and-duplex
#20
COMPARATIVE STUDY
Zhong-Liang Zhang, Yuan-Yan Wu, Kun Xi, Jian-Ping Sang, Zhi-Jie Tan
Ion-mediated interaction between DNAs is essential for DNA condensation, and it is generally believed that monovalent and nonspecifically binding divalent cations cannot induce the aggregation of double-stranded (ds) DNAs. Interestingly, recent experiments found that alkaline earth metal ions such as Mg(2+) can induce the aggregation of triple-stranded (ts) DNAs, although there is still a lack of deep understanding of the surprising findings at the microscopic level. In this work, we employed all-atom dynamic simulations to directly calculate the potentials of mean force (PMFs) between tsDNAs, between dsDNAs, and between tsDNA and dsDNA in Mg(2+) solutions...
August 8, 2017: Biophysical Journal
keyword
keyword
90286
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"