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https://www.readbyqxmd.com/read/28218607/tet2-asxl1-idh1-and-idh2-single-nucleotide-polymorphisms-in-turkish-patients-with-chronic-myeloproliferative-neoplasms
#1
Nur Soyer, Burçin Tezcanlı Kaymaz, Melda Cömert Özkan, Çağdaş Aktan, Ali Şahin Küçükaslan, Fahri Şahin, Buket Kosova, Güray Saydam
We aimed to determine the genotype distribution, allele frequency and prognostic impact of IDH1/2(Isocitrate dehydrogenase), TET2(Ten-Eleven-Translocation2) and ASXL1(Additional Sex Combs-Like 1) single nucleotide polymorphisms (SNPs) in MPNs. TET2(rs763480), ASXL1(rs2208131) and IDH1(rs11554137) variant homozygous genotype frequencies were 1.5%, 9.2% and 2.3%, respectively. No IDH2 SNP was identified. IDH1 and TET2 frequencies were 5% in ET and 1.7% in ET, 5% in PMF, respectively. ASXL1 frequencies were 8...
February 20, 2017: Turkish Journal of Haematology: Official Journal of Turkish Society of Haematology
https://www.readbyqxmd.com/read/28211698/demethylation-of-polymethoxyflavones-by-human-gut-bacterium-blautia-sp-mrg-pmf1
#2
Supawadee Burapan, Mihyang Kim, Jaehong Han
Polymethoxyflavones (PMFs) were biotransformed to various demethylated metabolites in the human intestine by the PMF-metabolizing bacterium, Blautia sp. MRG-PMF1. Because the newly formed metabolites can have different biological activities, the pathways and regioselectivity of PMF bioconversion were investigated. Using an anaerobic in vitro study, 12 PMFs, 5,7-dimethoxyflavone (5,7-DMF), 5-hydroxy-7-methoxyflavone (5-OH-7-MF), 3,5,7-trimethoxyflavone (3,5,7-TMF), 5-hydroxy-3,7-dimethoxyflavone (5-OH-3,7-DMF), 5,7,4'-trimethoxyflavone (5,7,4'-TMF), 5-hydroxy-7,4'-dimethoxyflavone (5-OH-7,4'-DMF), 3,5,7,4'-tetramethoxyflavone (3,5,7,4'-TMF), 5-hydroxy-3,7,4'-trimethoxyflavone (5-OH-3,7,4'-TMF), 5,7,3',4'-tetramethoxyflavone (5,7,3',4'-TMF), 3,5,7,3',4'-pentamethoxyflavone (3,5,7,3',4'-PMF), 5-hydroxy-3,7,3',4'-tetramethoxyflavone (5-OH-3,7,3',4'-TMF), and 5,3'-dihydroxy-3,7,4'-trimethoxyflavone (5,3'-diOH-3,7,4'-TMF), were converted to chrysin, apigenin, galangin, kaempferol, luteolin, and quercetin after complete demethylation...
February 17, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28211153/the-prognostic-relevance-of-serum-lactate-dehydrogenase-and-mild-bone-marrow-reticulin-fibrosis-in-essential-thrombocythemia
#3
Mythri Mudireddy, Daniela Barraco, Curtis A Hanson, Animesh Pardanani, Naseema Gangat, Ayalew Tefferi
The 2016 World Health Organization (WHO) diagnostic criteria for myeloproliferative neoplasms (MPN) underscore the prognostically-relevant distinction between essential thrombocythemia (ET) and prefibrotic primary myelofibrosis (pre-PMF). In addition, leukocytosis has been identified as an important prognostic marker in otherwise WHO-defined ET. However, controversy remains regarding the objectivity of morphologic criteria in distinguishing ET from pre-PMF and the precise prognostic cutoff values for leukocytosis...
February 17, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28202226/air-pollution-pm2-5-composition-source-factors-and-respiratory-symptoms-in-asthmatic-and-nonasthmatic-children-in-santiago-chile
#4
Laura Prieto-Parra, Karla Yohannessen, Cecilia Brea, Daniella Vidal, Carlos A Ubilla, Pablo Ruiz-Rudolph
The objective of this study was to determine the association of respiratory symptoms and medication use and exposure to various air pollutants, PM2.5 components, and source factors in a panel of asthmatic and nonasthmatic children in Santiago, Chile. To this end, 174 children (90 asthmatics and 84 nonasthmatics) were followed throughout the winter months of 2010 and 2011. During the study period, children filled out daily diaries to record respiratory symptoms and medication use. Air pollution data were obtained from government central site measurements and a PM2...
February 12, 2017: Environment International
https://www.readbyqxmd.com/read/28198853/linearly-polarized-low-noise-brillouin-random-fiber-laser
#5
Liang Zhang, Yanping Xu, Song Gao, Bhavaye Saxena, Liang Chen, Xiaoyi Bao
A linearly polarized Brillouin random fiber laser (LP-BRFL) with distributed feedback along 2 km polarization-maintaining fibers (PMFs) is demonstrated. The laser was built up using a bidirectional pumping mechanism in an all-PMF configuration, yielding a radiation with 8% power efficiency and more than 25 dB polarization extinction ratio. A high lasing efficiency is achieved due to the polarization-matched Brillouin amplification and distributed feedback along kilometer long PMFs. The relative intensity noise and the thermal-induced frequency noise of this random laser have also been measured and compared to that of a custom single-mode-fiber-based random laser and a conventional phase-locked laser...
February 15, 2017: Optics Letters
https://www.readbyqxmd.com/read/28186752/deconstructing-free-energies-in-the-law-of-matching-water-affinities
#6
Yu Shi, Thomas L Beck
The law of matching water affinities (LMWA) is explored in classical molecular dynamics simulations of several alkali halide ion pairs spanning the size range from small kosmotropes to large chaotropes. The ion-ion potentials of mean force (PMFs) are computed using three methods: the local molecular field theory (LMFT), the weighted histogram analysis method (WHAM), and integration of the average force (IAF). All three methods produce the same total PMF for a given ion pair. In addition, LMFT-based partitioning into van der Waals and local and far-field electrostatic free energies, and assessment of the enthalpic, entropic, and ion-water components, yield insights into the origins of the observed free energy profiles in water...
February 10, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28186751/the-relationship-between-solvation-thermodynamics-from-ist-and-dft-perspectives
#7
Ronald M Levy, Di Cui, Bin W Zhang, Nobuyuki Matubayasi
Inhomogeneous Solvation Theory (IST) and classical Density Functional Theory (DFT) each provide a framework for relating distribution functions of solutions to their thermodynamic properties. As reviewed in this work, both IST and DFT can be formulated in a way that use two "end point" simulations, one of the pure solvent and the other of the solution, to determine the solute chemical potential and other thermodynamic properties of the solution and of subvolumes in regions local to the solute containing hydrating waters...
February 10, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28185911/transcriptome-analysis-of-monozygotic-twin-brothers-with-childhood-primary-myelofibrosis
#8
Nan Ding, Zhaojun Zhang, Wenyu Yang, Lan Ren, Yingchi Zhang, Jingliao Zhang, Zhanqi Li, Peihong Zhang, Xiaofan Zhu, Xiaojuan Chen, Xiangdong Fang
Primary myelofibrosis (PMF) is a chronic myeloproliferative disorder in human bone marrow. Over 50% of patients with myelofibrosis have mutations in JAK2, MPL, or CALR. However, these mutations are rarely detected in children, suggesting a difference in the pathogenesis of childhood PMF. In this study, we investigated the response to drug treatment of a monozygotic twin pair with typical childhood PMF. The twin exhibited different clinical outcomes despite following the same treatment regimen. The transcriptomic profiles of patient samples after drug treatment (E2 and Y2) were significantly different between the twin pair, which is consistent with the observation that the drug treatment was effective only in the younger brother, despite the twin being genetically identical...
February 6, 2017: Genomics, Proteomics & Bioinformatics
https://www.readbyqxmd.com/read/28185178/spatiotemporal-distribution-and-source-apportionment-of-low-molecular-weight-organic-acids-in-wet-precipitation-at-a-coastal-city-china
#9
Wenjiao Du, Zhenyu Hong, Yanting Chen, Junjun Deng, Jinsheng Chen, Lingling Xu, Youwei Hong, Hang Xiao
To investigate the characteristics and sources of low molecular weight (LMW) organic acids in wet precipitation at a coastal city, Xiamen, a total of 313 rainwater samples were collected at seven different functional areas from September 2012 to August 2013. Spatiotemporal characteristics of LMW organic acids as well as pH and electrical conductivity were analyzed. Meanwhile, air mass clusters in different seasons and the positive matrix factorization (PMF) source apportion model were comprehensively used to identify the sources of organic acids...
February 9, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28182421/encapsulation-of-polymethoxyflavones-in-citrus-oil-emulsion-based-delivery-systems
#10
Ying Yang, Chengying Zhao, Jingjing Chen, Guifang Tian, David Julian McClements, Hang Xiao, Jinkai Zheng
The purpose of this work was to elucidate the effects of citrus oil type on polymethoxyflavone (PMF) solubility and on the physicochemical properties of PMF-loaded emulsion-based delivery systems. Citrus oils were extracted from mandarin, orange, sweet orange, and bergamot. The major constituents were determined by GC/MS: sweet orange oil (97.4% d-limonene); mandarin oil (72.4% d-limonene); orange oil (67.2% d-limonene); and bergamot oil (34.6% linalyl acetate and 25.3% d-limonene). PMF-loaded emulsions were fabricated using 10% oil phase (containing 0...
February 16, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28164603/study-on-the-clinical-significance-of-jak2v617f-allele-burden-in-philadelphia-chromosome-negative-myeloproliferative-neoplasm
#11
Peisong Chen, Juan Ouyang, Jianming Liang, Xuegao Yu, Bin Huang
BACKGROUND: It was discovered that the somatic mutation in JAK2 exon 14 (JAK2V617F) totally modified the understanding and diagnosis of Philadelphia-Negative myeloproliferative neoplasm (Ph-MPNs), including polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). Real-time quantitative PCR is the most widely used method for JAK2V617F detection in clinical laboratory. In this study, we aimed to evaluate the clinical significance of JAK2V617F allele burden in Ph-MPNs detected by real-time quantitative PCR...
August 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28159675/transforming-growth-factor-%C3%AE-and-interleukin-13-producing-mast-cells-are-associated-with-fibrosis-in-bone-marrow
#12
Shoko Nakayama, Taiji Yokote, Nobuya Hiraoka, Toshikazu Akioka, Uta Nishiwaki, Takuji Miyoshi, Kazuki Iwaki, Ayami Fumimoto, Yuki Masuda, Jun Hatooka, Mayumi Fujimoto, Yasuichiro Nishimura, Motomu Tsuji
Although bone marrow fibrosis is a lethal condition, its underlying mechanism is not fully understood. This study aimed to investigate the pathogenesis of fibrosis in the bone marrow through histological examination of mast cell infiltration and the expression of fibrosis-associated cytokines. We analyzed 22 bone marrows with fibrosis [eight primary myelofibrosis (PMF), five post-essential thrombocythemia (ET) myelofibrosis (MF), and nine myelodysplastic syndrome (MDS) with bone marrow fibrosis (BMF)]. Immunohistochemical and immunofluorescence staining were performed using anti-mast cell tryptase, interleukin (IL)-13, transforming growth factor-beta (TGF-β), CD34, and CD42b antibodies...
January 31, 2017: Human Pathology
https://www.readbyqxmd.com/read/28159306/source-apportionment-of-pm2-5-in-baton-rouge-louisiana-during-2009-2014
#13
Fenglin Han, Sri Harsha Kota, Yungang Wang, Hongliang Zhang
Particulate matter with aerodynamic diameter <2.5μm (PM2.5) chemical composition data from the Speciation Trends Network (STN) site located in Baton Rouge, Louisiana were analyzed using the receptor Positive Matrix Factorization (PMF) model version 5.0. The PM2.5 samples were collected every third day from January 2009 to December 2014. Seven sources were identified, including secondary sulfate, secondary nitrate, industrial emissions, traffic, crustal dust, road dust and sea salt. The contributions of these seven sources to PM2...
January 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28157219/the-role-of-the-extracellular-matrix-in-primary-myelofibrosis
#14
REVIEW
O Leiva, S K Ng, S Chitalia, A Balduini, S Matsuura, K Ravid
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm that arises from clonal proliferation of hematopoietic stem cells and leads to progressive bone marrow (BM) fibrosis. While cellular mutations involved in the development of PMF have been heavily investigated, noteworthy is the important role the extracellular matrix (ECM) plays in the progression of BM fibrosis. This review surveys ECM proteins contributors of PMF, and highlights how better understanding of the control of the ECM within the BM niche may lead to combined therapeutic options in PMF...
February 3, 2017: Blood Cancer Journal
https://www.readbyqxmd.com/read/28147291/source-apportionment-of-ambient-fine-and-coarse-particulate-matter-at-the-fort-mckay-community-site-in-the-athabasca-oil-sands-region-alberta-canada
#15
Matthew S Landis, J Patrick Pancras, Joseph R Graney, Emily M White, Eric S Edgerton, Allan Legge, Kevin E Percy
An ambient air particulate matter sampling study was conducted at the Wood Buffalo Environmental Association (WBEA) AMS-1 Fort McKay monitoring station in the Athabasca Oil Sand Region (AOSR) in Alberta, Canada from February 2010 to July 2011. Daily 24h integrated fine (PM2.5) and coarse (PM10-2.5) particulate matter was collected using a sequential dichotomous sampler. Over the duration of the study, 392 valid daily dichotomous PM2.5 and PM10-2.5 sample pairs were collected with concentrations of 6.8±12.9μgm(-3) (mean±standard deviation) and 6...
January 29, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28143941/a-novel-molecular-assay-using-hybridisation-probes-and-melt-curve-analysis-for-calr-exon-9-mutation-detection-in-myeloproliferative-neoplasms
#16
Thomas Keaney, Louise O'Connor, Janusz Krawczyk, Moutaz A Abdelrahman, Amjad H Hayat, Margaret Murray, Michael O'Dwyer, Melanie Percy, Stehpen Langabeer, Karl Haslam, Barry Glynn, Ciara Mullen, Evelyn Keady, Sinéad Lahiff, Terry J Smith
AIMS: Somatic insertions/deletions in exon 9 of the calreticulin gene have been identified in patients with essential thrombocythemia and primary myelofibrosis. Over 55 mutations have been discovered, 80% of which consist of either type 1 52-bp deletion or type 2 5-bp insertion. Other mutations (types 3-5) in conjunction with types 1 and 2 account for >87% of identified mutations. The aim of this study was development of a rapid PCR-based assay using LightCycler Hybridisation Probes for the detection of type 1-5 CALR mutations...
January 31, 2017: Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28132156/selected-bioinformatic-tools-and-ms-maldi-tof-pmf-techniques-used-in-the-strategy-for-the-identification-of-oat-proteins-after-2-de
#17
Iwona Szerszunowicz, Dorota Nałęcz, Marta Dziuba
Computer analysis of protein maps obtained from the separation of proteins with two-dimensional polyacrylamide gel electrophoresis (2-DE), in combination with mass spectrometry (MS) analysis and selected bioinformatic tools is used in the strategy for the identification of oat proteins. In proteomic research the most often used MS technique is the combination of ion sources: matrix-assisted laser desorption/ionization (MALDI) and the analyzer of the time of flight (TOF), i.e., MALDI-TOF MS.This chapter describes the possibilities of the use of selected bioinformatic tools (UniProtKB database, ProtParam, Compute pI/MW programs) for initial identification of separated oat proteins (especially prolamin fractions) with the 2-DE technique...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28131475/concentration-ozone-formation-potential-and-source-analysis-of-volatile-organic-compounds-vocs-in-a-thermal-power-station-centralized-area-a-study-in-shuozhou-china
#18
Yulong Yan, Lin Peng, Rumei Li, Yinghui Li, Lijuan Li, Huiling Bai
Volatile organic compounds (VOCs) from two sampling sites (HB and XB) in a power station centralized area, in Shuozhou city, China, were sampled by stainless steel canisters and measured by gas chromatography-mass selective detection/flame ionization detection (GC-MSD/FID) in the spring and autumn of 2014. The concentration of VOCs was higher in the autumn (HB, 96.87 μg/m(3); XB, 58.94 μg/m(3)) than in the spring (HB, 41.49 μg/m(3); XB, 43.46 μg/m(3)), as lower wind speed in the autumn could lead to pollutant accumulation, especially at HB, which is a new urban area surrounded by residential areas and a transportation hub...
January 25, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28131453/particulate-pollution-in-urban-chongqing-of-southwest-china-historical-trends-of-variation-chemical-characteristics-and-source-apportionment
#19
Yuan Chen, Shao-Dong Xie, Bin Luo, Chong-Zhi Zhai
Chongqing, the largest megacity in southwest China, faces serious aerosol pollution but lacks information on particle characteristics and its sources. Official data released by Chongqing Environmental Protection Bureau demonstrated that urban PM10 concentrations decreased remarkably from 150μgm(-3) in 2000 to 90μgm(-3) in 2012. However, only several peer-reviewed studies paid attention to local fine particle (PM2.5) pollution. In the study, PM2.5 samples were obtained and subjected to chemical analysis in an urban site of the city during 2012 to 2013...
January 25, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28130880/pulsed-magnetic-field-enhances-therapeutic-efficiency-of-mesenchymal-stem-cells-in-chronic-neuropathic-pain-model
#20
Tufan Mert, Akif Hakan Kurt, İdiris Altun, Ahmet Celik, Furkan Baran, Ismail Gunay
Cell-based or magnetic field therapies as alternative approaches to pain management have been tested in several experimental pain models. The aim of this study therefore was to investigate the actions of the cell-based therapy (adipose tissue derived mesenchymal stem cells; ADMSC) or pulsed magnetic field (PMF) therapy and magneto-cell therapy (combination of ADMSC and PMF) in chronic constriction nerve injury model (CCI). The actions of individual ADMSC (route dependent [systemic or local], time-dependent [a day or a week after surgery]), or PMF and their combination (magneto-cell) therapies on hyperalgesia and allodynia were investigated by using thermal plantar test and a dynamic plantar aesthesiometer, respectively...
January 28, 2017: Bioelectromagnetics
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