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Su-Lun Hwang, Miao-Ching Chi, Su-Er Guo, Yu-Ching Lin, Chiang-Ting Chou, Chieh-Mo Lin
The aim of this study is to investigate the seasonal variations and source apportionment on atmospheric fine particulate matter (PM2.5) mass and associated trace element concentrations at a coastal area, in Chiayi County of southwestern Taiwan. Particle measurements were conducted in 2015. Twenty-three trace elements in PM2.5 were analyzed using inductively coupled plasma mass spectrometry (ICP-MS). Multiple approaches of the enrichment factor (EF) analysis and positive matrix fraction (PMF) model were used to identify potential sources of PM2...
January 16, 2018: Environmental Science and Pollution Research International
Xueping Luo, Zefeng Xu, Bing Li, Tiejun Qin, Peihong Zhang, Hongli Zhang, Liwei Fang, Lijuan Pan, Naibo Hu, Shiqiang Qu, Yue Zhang, Gang Huang, Robert Peter Gale, Zhijian Xiao
Low-dose thalidomide and prednisone alone or combined are effective therapies in some persons with primary myelofibrosis (PMF) and anemia with or with RBC transfusion dependence. Danazol is also effective in some persons with PMF and anemia. Responses to these drugs are typically incomplete and not sustained. It is unclear whether adding danazol to thalidomide and prednisone would improve efficacy. We retrospectively compared the outcomes of 88 subjects with PMF and anemia receiving thalidomide and prednisone without (n = 46) or with danazol (n = 42)...
January 15, 2018: Blood Cancer Journal
Xiuduan Chen, Xinwei Lu
As soil-extractable elements potentially pose ecological and health risks, identifying their contamination characteristics and sources is crucial. Therefore, to understand topsoil trace elements in the urban ring zone from the Second Ring Road to the Third Ring of Xi'an city in China, we determined the concentrations of Zn, Co, V, As, Cu, Mn, Ba, Ni and Pb, and analyzed the sources of the contamination. The results showed that the individual pollution indices of Pb, Co, Cu, Zn, Ba, Ni, Mn, As, and V were 1...
January 11, 2018: Ecotoxicology and Environmental Safety
Md Aynul Bari, Warren B Kindzierski
An investigation of ambient levels and sources of volatile organic compounds (VOCs) and associated public health risks was carried out at two northern Alberta oil sands communities (Fort McKay and Fort McMurray located < 25 km and >30 km from oil sands development, respectively) for the period January 2010-March 2015. Levels of total detected VOCs were comparatively similar at both communities (Fort McKay: geometric mean = 22.8 μg/m3, interquartile range, IQR = 13.8-41 μg/m3); (Fort McMurray: geometric mean = 23...
January 11, 2018: Environmental Pollution
Denis G Knyazev, Roland Kuttner, Mirjam Zimmermann, Ekaterina Sobakinskaya, Peter Pohl
This review focusses on the energetics of protein translocation via the Sec translocation machinery. First we complement structural data about SecYEG's conformational rearrangements by insight obtained from functional assays. These include measurements of SecYEG permeability that allow assessment of channel gating by ligand binding and membrane voltage. Second we will discuss the power stroke and Brownian ratcheting models of substrate translocation and the role that the two models assign to the putative driving forces: (i) ATP (SecA) and GTP (ribosome) hydrolysis, (ii) interaction with accessory proteins, (iii) membrane partitioning and folding, (iv) proton motive force (PMF), and (v) entropic contributions...
January 12, 2018: Journal of Membrane Biology
Junqing Zhao, Lei Li, Luming Zhao, Dingyuan Tang, Deyuan Shen
We report on a type of 2 μm h-shaped pulse generation in a thulium-holmium-doped fiber laser and experimentally investigate its cavity birefringence and pump power dependences. An asymmetric nonlinear optical loop mirror is employed as an artificial saturable absorber, which incorporates ∼52.7  m dispersion-shifted fiber and ∼3.8  m ultra-high numerical aperture fiber to enhance the nonlinearity. The h-shaped pulse shows both a polarization state (PS) and pump power related evolutions, even when randomly weak birefringence fibers are employed...
January 15, 2018: Optics Letters
Jamal Adiban, Yousef Jamali, Hashem Rafii-Tabar
CaV channels are transmembrane proteins that mediate and regulate ions fluxes across cell membranes, and they are activated in response to action potentials to allow Ca2+ influx. Since ion channels are composed of charge or polar groups, an external alternating electric field may affect the ion-selective membrane transport and the performance of the channel. In this paper, we have investigated the effect of an external GHz electric field on the dynamics of calcium ions in the selectivity filter of the CaV Ab channel...
January 11, 2018: Proteins
Khosro Ashrafi, Reza Fallah, Mostafa Hadei, Marayam Yarahmadi, Abbas Shahsavani
There is a compelling need for apportionment of pollutants' sources to facilitate their reduction through proper management plans. The present study was designed to determine the contribution of each possible source of total suspended particles in Ahvaz's ambient air using positive matrix factorization (PMF), chemical mass balance (CMB), and the SPECIATE database. The sampling program undertaken followed EPA's guidelines and finally resulted in 74 samples. The concentration of 33 elemental and 10 ionic species were measured during a whole year...
January 8, 2018: Archives of Environmental Contamination and Toxicology
J Evers, M Fischer, I Zderic, D Wähnert, R G Richards, B Gueorguiev, M J Raschke, S Ochman
AIMS: The aim of this study was to investigate the effect of a posterior malleolar fragment (PMF), with < 25% ankle joint surface, on pressure distribution and joint-stability. There is still little scientific evidence available to advise on the size of PMF, which is essential to provide treatment. To date, studies show inconsistent results and recommendations for surgical treatment date from 1940. MATERIALS AND METHODS: A total of 12 cadaveric ankles were assigned to two study groups...
January 2018: Bone & Joint Journal
Manee M Manee, Sultan N Alharbi, Abdulmalek T Algarni, Waleed M Alghamdi, Musaad A Altammami, Mohammad N Alkhrayef, Basel M Alnafjan
Small heat shock protein beta-1 (HSPB-1) plays an essential role in the protection of cells against environmental stress.Elucidation of its molecular, structural, and biological characteristics in a naturally wild-type model is essential. Although the sequence information of the HSPB-1 gene is available for many mammalian species, the HSPB-1 gene of Arabian camel (Arabian camel HSPB-1) has not yet been structurally characterized. We cloned and functionally characterized a full-length of Arabian camel HSPB-1 cDNA...
2017: PloS One
Juan Li, Daniel Prins, Hyun Jung Park, Jacob Grinfeld, Carlos Gonzalez-Arias, Stephen Loughran, Oliver M Dovey, Thorsten Klampfl, Cavan Bennett, Tina L Hamilton, Dean C Pask, Rachel Sneade, Matthew Williams, Juliet Aungier, Cedric Ghevaert, George S Vassiliou, David G Kent, Anthony R Green
Somatic mutations in the endoplasmic reticulum chaperone calreticulin (CALR) are detected in approximately 40% of patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF). Multiple different mutations have been reported, but all result in a +1bp frame shift and generate a novel protein C-terminus. In this study, we generated a conditional mouse knock-in model of the most common CALR mutation, a 52bp deletion. The mutant novel human C-terminal sequence is integrated into the otherwise intact mouse CALR gene and results in mutant CALR expression under the control of the endogenous mouse locus...
December 27, 2017: Blood
Madhulika Gupta, Tuhin Suvra Khan, Manish Agarwal, M Ali Haider
Interaction of Methionine (Met) with different bimetallic-segregated surfaces comprising of uniform distribution, strips and islands of Au on Pd (111) surface were examined using molecular dynamics (MD) simulations. Out of all the segregated and uniformly doped surfaces studied, the design of Pd-Au islands showed some reduction in the interaction energy (Eint= -43.7 kJ/mol) as compared to the pure Pd (111) surface (Eint= -50 kJ/mol) for a single Met molecule. However, at a higher coverage of 9 Met molecules/simulation cell, none of the Pd-Au alloy surfaces showed any improvement as compared to the Pd (111) surface...
December 27, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Yasuhiro Tsukamoto, Junichi Kiyasu, Mariko Tsuda, Motohiko Ikeda, Motoaki Shiratsuchi, Yoshihiro Ogawa, Yuji Yufu
A 73-year-old man with primary myelofibrosis (PMF) was being treated with hydroxyurea, which was changed to ruxolitinib treatment because of worsening constitutional symptoms. Although ruxolitinib rapidly induced relief, he developed a high-grade fever. A comprehensive fever work-up found no apparent cause of the fever, except for PMF. Therefore, we increased the dose of ruxolitinib and added prednisolone, which was gradually withdrawn with resolution of the fever. However, the patient subsequently developed disseminated tuberculosis and died eight months after initiation of ruxolitinib...
December 27, 2017: Internal Medicine
Prithviraj Bose, Jason Gotlib, Claire N Harrison, Srdan Verstovsek
The discovery of the activating Janus kinase (JAK)2V617F mutation in 2005 in most patients with the classic Philadelphia chromosome-negative myeloproliferative neoplasms (MPN) spurred intense interest in research into these disorders, culminating in the identification of activating mutations in MPL in 2006 and indels in the gene encoding calreticulin (CALR) in 2013, thus providing additional mechanistic explanations for the universal activation of JAK-signal transducer and activator of transcription (JAK-STAT) observed in these conditions, and the success of the JAK1/2 inhibitor ruxolitinib, which first received regulatory approval in 2011...
January 2018: Clinical Lymphoma, Myeloma & Leukemia
Faiyaz K Shaikh, Prafull P Gadge, Manohar V Padul, Manvendra S Kachole
Helicoverpa armigera is an orthodox rival of many crop plants affecting agricultural economy. Plant leaves found to accumulate proteinase inhibitors, although this insect pest chooses leaves for laying eggs. Plant defense response at this juncture is not fully explored. In this context, here we are reporting proteinase inhibitor (ppLPI-1) having significant homology with the I13 family from leaves of pigeonpea (cv. BSMR 736). The isolation of ppLPI-1 was carried out from leaves of field-grown pigeonpea under an outbreak of H...
January 2018: 3 Biotech
Deepchandra Srivastava, Sophie Tomaz, Olivier Favez, Grazia Maria Lanzafame, Benjamin Golly, Jean-Luc Besombes, Laurent Y Alleman, Jean-Luc Jaffrezo, Véronique Jacob, Emilie Perraudin, Eric Villenave, Alexandre Albinet
PM10 source apportionment was performed by positive matrix factorization (PMF) using specific primary and secondary organic molecular markers on samples collected over a one year period (2013) at an urban station in Grenoble (France). The results provided a 9-factor optimum solution, including sources rarely apportioned in the literature, such as two types of primary biogenic organic aerosols (fungal spores and plant debris), as well as specific biogenic and anthropogenic secondary organic aerosols (SOA). These sources were identified thanks to the use of key organic markers, namely, polyols, odd number higher alkanes, and several SOA markers related to the oxidation of isoprene, α-pinene, toluene and polycyclic aromatic hydrocarbons (PAHs)...
December 21, 2017: Science of the Total Environment
Di Cui, Bin W Zhang, Nobuyuki Matubayasi, Ronald M Levy
Classical density functional theory (DFT) can be used to relate the thermodynamic properties of solutions to the indirect solvent mediated part of the solute-solvent potential of mean force (PMF). Standard, but powerful numerical methods can be used to estimate the solute-solvent PMF from which the indirect part can be extracted. In this work we show how knowledge of the direct and indirect parts of the solute-solvent PMF for water at the interface of a protein receptor can be used to gain insights about how to design tighter binding ligands...
December 20, 2017: Journal of Chemical Theory and Computation
Huan Wang, Xueming Tang, David Michael Eike, Ronald G Larson, Peter H Koenig
We present a scheme to calculate wormlike micelle scission free energies from a potential of mean force (PMF) derived from a Weighted Histogram Analysis Method (WHAM) applied to coarse grained dissipative particle dynamics (DPD) simulations. In contrast to previous related work, we use a specially chosen external potential based on a reaction coordinate that reversibly drives surfactants out of the nascent scission location. For the application to a model body wash formulation, we predict how addition of NaCl and small molecules such as perfume raw materials (PRMs) affect scission energies...
December 15, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
Yuanhong Yang, Hui Li, Lin Lu, Fuling Yang, Wei Jin
Gamma radiation-induced birefringence (RIB) variations in a solid core photonic crystal polarization-maintaining fiber (Pc-PMF) and a Panda PMF (Pa-PMF) are investigated. Experiments show that the birefringence of the fibers changes approximately linearly with a radiation dose over the range from 0 to 400 krad(Si), with negative slope coefficients of 8.91×10-10/krad(Si) and 4.38×10-9/krad(Si) for the Pc-PMF and Pa-PMF, respectively. Models of RIB variations for the two fibers are established, and the theoretical results agree well with the experimental ones...
December 15, 2017: Optics Letters
Hui Li, Christopher Paolucci, William F Schneider
The ability of metal-exchanged-zeolites to chemisorb small gas molecules is key to their performance as heterogeneous catalysts and gas-separating-agents. Here we propose and evaluate an ab initio potential of mean force (PMF) method for computing adsorption free energies of representative small molecules to Cu-exchanged sites in SSZ-13 zeolite. We show that Cu ions are mobilized by adsorbates and, as a result, computed free energies are significantly more negative than those obtained from a conventional harmonic oscillator model...
December 12, 2017: Journal of Chemical Theory and Computation
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