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https://www.readbyqxmd.com/read/28520413/temporal-characteristics-of-brown-carbon-over-the-central-indo-gangetic-plain
#1
Rangu Venkata Satish, Puthukkadan Moosakutty Shamjad, Navaneeth M Thamban, Sachchida N Tripathi, Neeraj Rastogi
Recent global models estimate that light absorption by brown carbon (BrC) in several regions of the world is ~30-70% of that due to black carbon (BC). It is, therefore, important to understand its sources and characteristics on temporal and spatial scale. In this study, we conducted semi-continuous measurements of water-soluble organic carbon (WSOC) and BrC using particle-into-liquid sampler coupled with liquid waveguide capillary cell and total carbon analyzer (PILS-LWCC-TOC) over Kanpur (26.5°N, 80.3°E, 142 m amsl) during a winter season (December 2015 to February 2016)...
May 18, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28516003/mode-of-action-of-the-2-phenylquinoline-efflux-inhibitor-pqq4r-against-escherichia-coli
#2
Diana Machado, Laura Fernandes, Sofia S Costa, Rolando Cannalire, Giuseppe Manfroni, Oriana Tabarrini, Isabel Couto, Stefano Sabatini, Miguel Viveiros
Efflux pump inhibitors are of great interest since their use as adjuvants of bacterial chemotherapy can increase the intracellular concentrations of the antibiotics and assist in the battle against the rising of antibiotic-resistant bacteria. In this work, we have described the mode of action of the 2-phenylquinoline efflux inhibitor (4-(2-(piperazin-1-yl)ethoxy)-2-(4-propoxyphenyl) quinolone - PQQ4R), against Escherichia coli, by studding its efflux inhibitory ability, its synergistic activity in combination with antibiotics, and compared its effects with the inhibitors phenyl-arginine-β-naphthylamide (PAβN) and chlorpromazine (CPZ)...
2017: PeerJ
https://www.readbyqxmd.com/read/28515738/chloroplast-atp-synthase-modulation-of-the-thylakoid-proton-motive-force-implications-for-photosystem-i-and-photosystem-ii-photoprotection
#3
Atsuko Kanazawa, Elisabeth Ostendorf, Kaori Kohzuma, Donghee Hoh, Deserah D Strand, Mio Sato-Cruz, Linda Savage, Jeffrey A Cruz, Nicholas Fisher, John E Froehlich, David M Kramer
In wild type plants, decreasing CO2 lowers the activity of the chloroplast ATP synthase, slowing proton efflux from the thylakoid lumen resulting in buildup of thylakoid proton motive force (pmf). The resulting acidification of the lumen regulates both light harvesting, via the qE mechanism, and photosynthetic electron transfer through the cytochrome b6f complex. Here, we show that the cfq mutant of Arabidopsis, harboring single point mutation in its γ-subunit of the chloroplast ATP synthase, increases the specific activity of the ATP synthase and disables its down-regulation under low CO2...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28514304/diagnostic-and-clinical-application-value-of-magnetic-resonance-imaging-mri-for-progressive-massive-fibrosis-of-coal-worker-pneumoconiosis-case-reports
#4
Lansheng Zhang, Chun Wang, Qiuyue Yan, Tao Zhang, Zhengxiang Han, Guan Jiang
RATIONALE: Using magnetic resonance imaging (MRI), we diagnosed pneumoconiosis by identifying the content and distribution of hydrogen protons in the water molecules in different tissues and lesions. PATIENT CONCERNS: 25 cases of CWP patients with progressive massive fibrosis (PMF) lesions. DIAGNOSES: Patients were correctly diagnosed, with one case each of Phase I and II pneumoconiosis and 23 cases of Phase III pneumoconiosis. INTERVENTIONS: None...
May 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28509339/comparison-of-jak2-v617f-positive-essential-thrombocythaemia-and-early-primary-myelofibrosis-the-impact-of-mutation-burden-and-histology
#5
Roberto Latagliata, Nicola Polverelli, Alessia Tieghi, Giuseppe Alberto Palumbo, Massimo Breccia, Elena Sabattini, Loredana Villari, Mara Riminucci, Riccardo Valli, Lucia Catani, Giuliana Alimena, Emanuela Ottaviani, Angelo Fama, Giovanni Martinelli, Margherita Perricone, Marco Spinsanti, Michele Cavo, Nicola Vianelli, Francesca Palandri
An accurate histological diagnosis may distinguish essential thrombocythaemia (ET) from early primary myelofibrosis (early-PMF), which is associated with worse outcome. Outcome of ET is also negatively affected by the presence of the JAK2(V617F) mutation. To investigate the impact of JAK2(V617F) mutation burden and histology on outcome, we collected 475 WHO-diagnosed ET (69.2%) or early-PMF JAK2(V617F) -positive patients followed in 4 Italian haematology centers. JAK2(V617F) allele burden was ≤50% in 90% and 87% of ET and early-PMF patients, respectively (P = ...
May 16, 2017: Hematological Oncology
https://www.readbyqxmd.com/read/28481328/leptin-receptor-expressing-bone-marrow-stromal-cells-are-myofibroblasts-in-primary-myelofibrosis
#6
Matthew Decker, Leticia Martinez-Morentin, Guannan Wang, Yeojin Lee, Qingxue Liu, Juliana Leslie, Lei Ding
Bone marrow fibrosis is a critical component of primary myelofibrosis (PMF). However, the origin of the myofibroblasts that drive fibrosis is unknown. Using genetic fate mapping we found that bone marrow leptin receptor (Lepr)-expressing mesenchymal stromal lineage cells expanded extensively and were the fibrogenic cells in PMF. These stromal cells downregulated the expression of key haematopoietic-stem-cell-supporting factors and upregulated genes associated with fibrosis and osteogenesis, indicating fibrogenic conversion...
May 8, 2017: Nature Cell Biology
https://www.readbyqxmd.com/read/28468090/-clinical-significance-of-jak2%C3%A3-calr-and-mpl-gene-mutations-in-1-648-philadelphia-chromosome-negative-myeloproliferative-neoplasms-patients-from-a-single-center
#7
M Y Li, H Y Chao, A N Sun, H Y Qiu, Z M Jin, X W Tang, Y Han, C C Fu, S N Chen, D P Wu
Objective: To explore the prevalences of JAK2, CALR and MPL gene mutations and the mutation types in patients with Philadelphia chromosome negative myeloproliferative neoplasms (MPNs) , and to compare their clinical characteristics of different mutation types with each other and mutation negative group. Methods: The mutations of JAK2 V617F, JAK2 gene at exon 12, CALR gene at exon 9 and MPL gene at exon 10 in 1 648 Ph negative MPNs patients were detected by direct sequencing. Results: ① The JAK2V617F mutation was found in 471 (92...
April 14, 2017: Zhonghua Xue Ye Xue za Zhi, Zhonghua Xueyexue Zazhi
https://www.readbyqxmd.com/read/28455568/chemical-characteristics-and-source-apportionment-of-pm2-5-using-pca-apcs-unmix-and-pmf-at-an-urban-site-of-delhi-india
#8
Srishti Jain, Sudhir Kumar Sharma, Nikki Choudhary, Renu Masiwal, Mohit Saxena, Ashima Sharma, Tuhin Kumar Mandal, Anshu Gupta, Naresh Chandra Gupta, Chhemendra Sharma
The present study investigated the comprehensive chemical composition [organic carbon (OC), elemental carbon (EC), water-soluble inorganic ionic components (WSICs), and major & trace elements] of particulate matter (PM2.5) and scrutinized their emission sources for urban region of Delhi. The 135 PM2.5 samples were collected from January 2013 to December 2014 and analyzed for chemical constituents for source apportionment study. The average concentration of PM2.5 was recorded as 121.9 ± 93.2 μg m(-3) (range 25...
April 28, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28453938/simulated-force-quench-dynamics-shows-gb1-protein-is-not-a-two-state-folder
#9
Ronen Berkovich, Jagannath Mondal, Inga Paster, B J Berne
Single molecule force spectroscopy is a useful technique for investigating mechanically induced protein unfolding and refolding under reduced forces by monitoring the end-to-end distance of the protein. The data is often interpreted via a "two-state" model based on the assumption that the end-to-end distance alone is a good reaction coordinate and the thermodynamic behavior is then ascribed to the free energy as a function of this one reaction coordinate. In this paper, we determined the free energy surface (PMF) of GB1 protein from atomistic simulations in explicit solvent under different applied forces as a function of two collective variables (the end-to-end-distance, and the fraction of native contacts ρ)...
May 11, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28432892/arsenic-chromium-molybdenum-and-selenium-geochemical-fractions-and-potential-mobilization-in-riverine-soil-profiles-originating-from-germany-and-egypt
#10
Sabry M Shaheen, Eilhann E Kwon, Jayanta K Biswas, Filip M G Tack, Yong Sik Ok, Jörg Rinklebe
The fractionation and potential mobilization of As, Cr, Mo, and Se in four floodplain soil profiles collected along the Nile (Egypt) and Wupper (Germany) Rivers were assessed using the BCR sequential extraction procedure. The concentrations of total and the geochemical fractions (acid soluble (F1), reducible (F2), oxidizable (F3), and residual (F4) fraction) of the elements were determined. The Wupper soils had the highest total concentrations (mg kg(-1)) of As (378) and Cr (2,797) while the Nile soils contained the highest total Mo (12) and Se (42)...
April 14, 2017: Chemosphere
https://www.readbyqxmd.com/read/28426975/the-regulation-of-the-chloroplast-proton-motive-force-plays-a-key-role-for-photosynthesis-in-fluctuating-light
#11
REVIEW
Ute Armbruster, Viviana Correa Galvis, Hans-Henning Kunz, Deserah D Strand
Plants use sunlight as their primary energy source. During photosynthesis, absorbed light energy generates reducing power by driving electron transfer reactions. These are coupled to the transfer of protons into the thylakoid lumen, generating a proton motive force (pmf) required for ATP synthesis. Sudden alterations in light availability have to be met by regulatory mechanisms to avoid the over-accumulation of reactive intermediates and maximize energy efficiency. Here, the acidification of the lumen, as an intermediate product of photosynthesis, plays an important role by regulating photosynthesis in response to excitation energy levels...
April 17, 2017: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/28423484/mir-494-3p-overexpression-promotes-megakaryocytopoiesis-in-primary-myelofibrosis-hematopoietic-stem-progenitor-cells-by-targeting-socs6
#12
Sebastiano Rontauroli, Ruggiero Norfo, Valentina Pennucci, Roberta Zini, Samantha Ruberti, Elisa Bianchi, Simona Salati, Zelia Prudente, Chiara Rossi, Vittorio Rosti, Paola Guglielmelli, Giovanni Barosi, Alessandro Vannucchi, Enrico Tagliafico, Rossella Manfredini
Primary myelofibrosis (PMF) is a chronic Philadelphia-negative myeloproliferative neoplasm characterized by hematopoietic stem cell-derived clonal myeloproliferation, involving especially the megakaryocyte lineage. To better characterize how the altered expression of microRNAs might contribute to PMF pathogenesis, we have previously performed the integrative analysis of gene and microRNA expression profiles of PMF hematopoietic stem/progenitor cells (HSPCs), which allowed us to identify miR-494-3p as the upregulated microRNA predicted to target the highest number of downregulated mRNAs...
March 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422716/sequential-evaluation-of-calr-mutant-burden-in-patients-with-myeloproliferative-neoplasms
#13
Chiara Cavalloni, Elisa Rumi, Virginia V Ferretti, Daniela Pietra, Elisa Roncoroni, Marta Bellini, Michele Ciboddo, Ilaria C Casetti, Benedetta Landini, Elena Fugazza, Daniela Troletti, Cesare Astori, Mario Cazzola
We investigated the variation of CALR-mutant burden during follow-up in 105 CALR-mutant MPN and compared it to the variation of JAK2-mutant burden in 226 JAK2-mutant MPN.The median allele burden at last evaluation was significantly higher than at first evaluation in essential thrombocythemia (ET) (49.5% vs 45%, P < .001) but not in primary myelofibrosis (PMF) (52% vs 51%, P 0.398). Median values of slope were positive both in ET (0.071) and in PMF (0.032). In CALR-mutant ET there was a difference between natural and therapy-related slope (P 0...
May 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28422503/predicting-protein-interactions-of-concentrated-globular-protein-solutions-using-colloidal-models
#14
Mahlet A Woldeyes, Cesar Calero-Rubio, Eric M Furst, Christopher J Roberts
Protein interactions of α-chymotrypsinogen A (aCgn) were quantified using light scattering from low to high protein concentrations. Static light scattering (SLS) was used to determine the excess Rayleigh ratio (R(ex)) and osmotic second virial coefficients (B22) as a function of pH and total ionic strength (TIS). Repulsive (attractive) protein-protein interactions (PPI) were observed at pH 5 (pH 7), with decreasing repulsions (attractions) upon increasing TIS. Simple colloidal potential of mean force models (PMF) that account for short-range nonelectrostatic attractions and screened electrostatic interactions were used to fit model parameters from data for B22 vs TIS at both pH values...
May 11, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28421043/outlining-core-pathways-of-amyloid-toxicity-in-bacteria-with-the-repa-wh1-prionoid
#15
Laura Molina-García, María Moreno-Del Álamo, Pedro Botias, Zaira Martín-Moldes, María Fernández, Alicia Sánchez-Gorostiaga, Aída Alonso-Del Valle, Juan Nogales, Jesús García-Cantalejo, Rafael Giraldo
The synthetic bacterial prionoid RepA-WH1 causes a vertically transmissible amyloid proteinopathy in Escherichia coli that inhibits growth and eventually kills the cells. Recent in vitro studies show that RepA-WH1 builds pores through model lipid membranes, suggesting a possible mechanism for bacterial cell death. By comparing acutely (A31V) and mildly (ΔN37) cytotoxic mutant variants of the protein, we report here that RepA-WH1(A31V) expression decreases the intracellular osmotic pressure and compromise bacterial viability under either aerobic or anaerobic conditions...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28419183/comparison-of-the-mutational-profiles-of-primary-myelofibrosis-polycythemia-vera-and-essential-thrombocytosis
#16
Jinming Song, Mohammad Hussaini, Hailing Zhang, Haipeng Shao, Dahui Qin, Xiaohui Zhang, Zhenjun Ma, Syeda Mahrukh Hussnain Naqvi, Ling Zhang, Lynn C Moscinski
Objectives: To compare the mutational profiles of patients with primary myelofibrosis (PMF), polycythemia vera (PV), and essential thrombocytosis (ET). Methods: Next-generation sequencing results of 75 cases of PMF, 33 cases of PV, and 27 cases of ET were compared. Results: Mutation rates of ASXL1 and SRSF2 were significantly higher in PMF than in PV or ET. ASXL1 mutations appeared to be more frequently associated with risk of transformation to acute myeloid leukemia than JAK2 or TET2 mutations...
April 15, 2017: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/28417976/revealing-inhibition-difference-between-pfi-2-enantiomers-against-setd7-by-molecular-dynamics-simulations-binding-free-energy-calculations-and-unbinding-pathway-analysis
#17
Yuzhen Niu, Danfeng Shi, Lanlan Li, Jingyun Guo, Huanxiang Liu, Xiaojun Yao
SETD7 is associated with multiple diseases related signaling pathways. (R)-PFI-2 is the first SETD7 inhibitor with nanomolar inhibitory potency. The activity of (R)-PFI-2 is about 500 times over that of (S)-PFI-2. Understanding the mechanism behind this difference will be helpful to discovery and design of more potent SETD7 inhibitors. A computational study combining molecular dynamics simulation, binding free energy calculations, and residue interaction network (RIN) was performed on the (S)-PFI-2/SETD7 and (R)-PFI-2/SETD7 complexes to explore the molecular mechanism behind the different inhibition activity...
April 18, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28414753/sustained-low-peritoneal-effluent-ccl18-levels-are-associated-with-preservation-of-peritoneal-membrane-function-in-peritoneal-dialysis
#18
Marta Ossorio, María Auxiliadora Bajo, Gloria Del Peso, Virginia Martínez, María Fernández, María José Castro, Aranzazu Rodríguez-Sanz, Rosario Madero, Teresa Bellón, Rafael Selgas
Peritoneal membrane failure (PMF) and, ultimately, encapsulating peritoneal sclerosis (EPS) are the most serious peritoneal dialysis (PD) complications. Combining clinical and peritoneal transport data with the measurement of molecular biomarkers, such as the chemokine CCL18, would improve the complex diagnosis and management of PMF. We measured CCL18 levels in 43 patients' effluent and serum at baseline and after 1, 2, and 3 years of PD treatment by retrospective longitudinal study, and evaluated their association with PMF/EPS development and peritoneal risk factors...
2017: PloS One
https://www.readbyqxmd.com/read/28412487/occurrence-homologue-patterns-and-source-apportionment-of-short-%C3%A2-and-medium-chain-chlorinated-paraffins-in-suburban-soils-of-shanghai-china
#19
Xue-Tong Wang, Si-Yue Xu, Xi-Kui Wang, Bao-Ping Hu, Hao-Hao Jia
In order to systematically investigate the spatial distribution, homologue profiles, and sources of short- and medium-chain chlorinated paraffins (SCCPs and MCCPs) in suburban soils in Shanghai, SCCPs and MCCPs in soils were analyzed using gas chromatography coupled with low resolution mass spectrometry in electron capture negative ion (ECNI) mode (GC-ECNI-MS). The CP concentrations in soils were between not detected (ND) - 697 ng g(-1) with a median value of 3.52 ng g(-1) for SCCPs, and ND - 666 ng g(-1) with a median value of 15...
April 9, 2017: Chemosphere
https://www.readbyqxmd.com/read/28412402/flavonoid-composition-of-orange-peel-extract-ameliorates-alcohol-induced-tight-junction-dysfunction-in-caco-2-monolayer
#20
Xiu-Min Chen, David D Kitts
Dry citrus peels, also known as "chenpi", have been traditionally used to treat and relieve intestinal inflammation. Recently we have reported that orange peel extracts (OPE) which contain relatively greater polymethoxylated flavone (PMF) content exhibit superior antioxidant and anti-inflammatory activities in vitro. Moreover, these bioactivities were notably greater than an equivalent flavonoid mixture (FM). The present study compares the effects of different OPE sources with distinct PMF composition on tight junction (TJ) dysfunction induced by ethanol...
April 12, 2017: Food and Chemical Toxicology
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