keyword
MENU ▼
Read by QxMD icon Read
search

Pmf

keyword
https://www.readbyqxmd.com/read/27919530/sources-of-formaldehyde-and-their-contributions-to-photochemical-o3-formation-at-an-urban-site-in-the-pearl-river-delta-southern-china
#1
Z H Ling, J Zhao, S J Fan, X M Wang
Two models (the Positive Matrix Factorization (PMF) model and a photochemical box model with Master Chemical Mechanism (PBM-MCM)) were applied to analyze the formaldehyde (HCHO) data collected in July 2006 at an urban site (GPEMC) in the Pearl River Delta (PRD), southern China. Three major HCHO sources (secondary formation, vehicular exhaust, and solvent usage) were identified and they were found to contribute in average 53%, 31% and 16% respectively to the total HCHO loading at GPEMC. Alkenes was the most important group contributing to the secondary formation of HCHO, followed by aromatics and alkanes...
December 2, 2016: Chemosphere
https://www.readbyqxmd.com/read/27918045/modeling-ion-permeation-through-a-bacterial-voltage-gated-calcium-channel-cavab-using-molecular-dynamics-simulations
#2
Jamal Adiban, Yousef Jamali, Hashem Rafii-Tabar
Activation of voltage-gated calcium channels by action potentials leads to the influx of Ca(2+) ions. In this study, the ion permeation characteristics in bacterial voltage-gated calcium (CaVAb) channels were investigated using molecular dynamics simulations. Furthermore, the potential of mean force (PMF) calculations was evaluated to determine the free energy profile for the permeation of cations (Ca(2+) and Na(+)) and anions (Cl(-)) in the CaVAb channel. The results showed that both Ca(2+) and Na(+) cations experienced a deep energy well, while the Cl(-) anion experienced a relatively high energy barrier at the center of the selectivity filter (site 2)...
December 5, 2016: Molecular BioSystems
https://www.readbyqxmd.com/read/27913526/update-from-the-latest-who-classification-of-mpns-a-user-s-manual
#3
Francesco Passamonti, Margherita Maffioli
The 2016 multiparameter World Health Organization (WHO) classification for Philadelphia-negative myeloproliferative neoplasms (MPNs) integrates clinical features, morphology, and genetic data to diagnose polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). The main novelties are: (1) the reduction of the hemoglobin (Hb) level threshold to diagnose PV, now established at 16.5 g/dL for men and 16 g/dL for women (based on the identification of MPN patients with PV-consistent bone marrow [BM] features and a Hb level lower than that established in the 2008 WHO classification for PV); (2) the recognition of prefibrotic/early PMF, distinguishable from ET on the basis of BM morphology, an entity having a higher tendency to develop overt myelofibrosis or acute leukemia, and characterized by inferior survival; (3) the central role of BM morphology in the diagnosis of ET, prefibrotic/early PMF, PMF, and PV with borderline Hb values; megakaryocyte number and morphology (typical in ET, atypical in both PMF forms) accompanied by a new distinction of reticulin fibrosis grade in PMF (grade 1 in prefibrotic/early PMF and grade 2-3 in PMF) constitute diagnostic criteria; and (4) the inclusion of all mutually exclusive MPN driver mutations (JAK2, CALR, and MPL) as major diagnostic criteria in ET and PMF; 10% to 15% of these patients are triple negative, and in these cases the search for an additional clonal marker (eg, mutations in ASXL1, EZH2, TET2, IDH1/IDH2, SRSF2, and SF3B1) is warranted...
December 2, 2016: Hematology—the Education Program of the American Society of Hematology
https://www.readbyqxmd.com/read/27907857/membrane-effects-of-dihydropyrimidine-analogues-with-larvicidal-activity
#4
Mariela E Sánchez-Borzone, Maria E Mariani, Virginia Miguel, Raquel M Gleiser, Bharti Odhav, Katharigatta N Venugopala, Daniel A García
Two recently synthesized dihydropyrimidines (DHPMs) analogues have demonstrated larvicide and repellent activity against Anopheles arabiensis. DHPMs high lipophilicity suggests that these compounds may interact directly with the membrane and modify their biophysical properties. The purpose of the present study was to characterize the interaction of both compounds with artificial membranes. Changes on the properties of DPPC films were studied using Langmuir monolayers. The presence of DHPMs in the subphase modified the interfacial characteristics of DPPC compression isotherms, causing the expansion of the monolayer, inducing the disappearance of DPPC phase transition and increasing the molecular packing of the film...
November 24, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/27898895/effects-of-subacute-ruminal-acidosis-and-low-feed-intake-on-short-chain-fatty-acid-transporters-and-flux-pathways-in-holstein-steers
#5
A H Laarman, R-L A Pederzolli, K M Wood, G B Penner, B W McBride
The objective of this study was to investigate the role of protein-mediated transport pathways for short-chain fatty acid flux across the ruminal epithelium, using subacute ruminal acidosis (SARA) and feed restriction as models. Twenty-one Holstein steers (216.8 ± 31.4 kg BW) were individually housed and fed a total mixed ration (TMR) with a 50:50 forage:concentrate ad libitum for 5 d. After the 5 d diet adjustment period, calves were assigned 1 of 3 treatments: control (CTRL) calves were fed the TMR ad libitum on d 1, subacute ruminal acidosis calves were given 25% of their ad libitum DMI on d 1 and then given a barley grain challenge at 30% of ad libitum DMI on d2 (ACID) calves were given 25% of their ad libitum DMI on d 1 and then given a barley grain challenge at 30% of ad libitum DMI on d 2, and feed restriction (FR) calves were given 25% of their ad libitum DMI for 5 d...
September 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/27897264/the-association-between-smoking-and-epiretinal-membrane
#6
Sheng-Zhan Wang, Qi-Hu Tong, Hui-Yun Wang, Qin-Kang Lu, Yu-Feng Xu
We conducted a meta-analysis of analytic and observational studies to evaluate the association between smoking and epiretinal membrane (ERM). The pertinent studies were identified via a literature search using three databases (MEDLINE, Cochrane Library, Embase) and the reference lists of retrieved studies. Cohort, case-control and cross-sectional studies meeting the predefined criteria were included. We extracted the odds ratios (OR) and 95% confidence intervals (CI) from each study. Overall risk estimates were pooled using random-effects models...
November 29, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27896228/the-european-innovation-partnership-on-active-and-healthy-ageing-synergies-protocol-for-a-prospective-observational-study-to-measure-the-impact-of-a-community-based-program-on-prevention-and-mitigation-of-frailty-icp-pmf-in-community-dwelling-older-adults
#7
G Liotta, F Orfila, M Vollenbroek-Hutten, R Roller-Winsberger, M Illario, D Musian, S Alvino, R O'Caoimh, A Cano, W Molloy, G Iaccarino, M C Marazzi, M C Inzerilli, O Madaro, C Paul, P Csonka, A C Vince, E Menditto, M Maggio, P Scarcella, F Gilardi, F Lucaroni, P Abete, V Girardi, R Barra, L Palombi
Aim of this paper is to describe the protocol of the study "Impact of a Community-based Program on Prevention and Mitigation of Frailty in community-dwelling older adults" developed in the framework of the European Innovation Partnership on Active and Healthy Ageing. This proposal has been developed by the Partnership Action groups on frailty, fall prevention and polypharmacy in older. The proposal wants to assess the impact of community-based programs aimed to counteract three main outcomes related to frailty: hospitalization, institutionalization and death...
November 2016: Translational Medicine @ UniSa
https://www.readbyqxmd.com/read/27892678/characterization-and-prognosis-significance-of-jak2-v617f-mpl-and-calr-mutations-in-philadelphia-negative-myeloproliferative-neoplasms
#8
Roongrudee Singdong, Teerapong Siriboonpiputtana, Takol Chareonsirisuthigul, Adcharee Kongruang, Nittaya Limsuwanachot, Tanasan Sirirat, Suporn Chuncharunee, Budsaba Rerkamnuaychoke
Background: The discovery of somatic acquired mutations of JAK2 (V617F) in Philadelphia-negative myeloproliferative neoplasms (Ph-negative MPNs) including polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) has not only improved rational disease classification and prognostication but also brings new understanding insight into the pathogenesis of diseases. Dosage effects of the JAK2 (V617F) allelic burden in Ph-negative MPNs may partially influence clinical presentation, disease progression, and treatment outcome...
January 10, 2016: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/27870387/primary-myelofibrosis-2017-update-on-diagnosis-risk-stratification-and-management
#9
Ayalew Tefferi
: Disease overview: Primary myelofibrosis (PMF) is a myeloproliferative neoplasm (MPN) characterized by stem cell-derived clonal myeloproliferation that is often but not always accompanied by JAK2, CALR or MPL mutation, abnormal cytokine expression, bone marrow fibrosis, anemia, splenomegaly, extramedullary hematopoiesis (EMH), constitutional symptoms, cachexia, leukemic progression and shortened survival. DIAGNOSIS: Diagnosis is based on bone marrow morphology...
December 2016: American Journal of Hematology
https://www.readbyqxmd.com/read/27869840/tunable-mode-rotator-for-space-division-multiplexing-based-on-a-few-mode-polarization-maintaining-fiber
#10
Xiaobin Hong, Xinglin Zeng, Yan Li, Qi Mo, Yongjie Tian, Wei Li, Zhijian Liu, Jian Wu
In this paper, a fiber-based tunable mode rotator is proposed and demonstrated by using the few mode-polarization maintaining fiber (FM-PMF). The mode birefringence in the FM-PMF causes phase difference between two orthogonal degenerate modes. With rotating the FM-PMF segment and getting a variation of aligning angle between the injected LP<sub>11</sub> (LP<sub>21</sub>) mode axis and FM-PMF axis, another intended LP<sub>11</sub> (LP<sub>21</sub>) mode with a certain orientation can be controllably generated at the FM-PMF output...
November 20, 2016: Applied Optics
https://www.readbyqxmd.com/read/27866854/source-apportionment-of-fine-and-coarse-particles-at-a-roadside-and-urban-background-site-in-london-during-the-2012-summer-clearflo-campaign
#11
Leigh R Crilley, Franco Lucarelli, William J Bloss, Roy M Harrison, David C Beddows, Giulia Calzolai, Silvia Nava, Gianluigi Valli, Vera Bernardoni, Roberta Vecchi
London, like many major cities, has a noted air pollution problem, and a better understanding of the sources of airborne particles in the different size fractions will facilitate the implementation and effectiveness of control strategies to reduce air pollution. Thus, the trace elemental composition of the fine and coarse fraction were analysed at hourly time resolution at urban background (North Kensington, NK) and roadside (Marylebone Road, MR) sites within central London. Unlike previous work, the current study focuses on measurements during the summer providing a snapshot of contributing sources, utilising the high time resolution to improve source identification...
January 2017: Environmental Pollution
https://www.readbyqxmd.com/read/27833629/development-of-marker-free-insect-resistant-indica-rice-by-agrobacterium-tumefaciens-mediated-co-transformation
#12
Fei Ling, Fei Zhou, Hao Chen, Yongjun Lin
Agrobacterium-mediated co-transformation is an efficient strategy to generate marker-free transgenic plants. In this study, the vectors pMF-2A(∗) containing a synthetic cry2A(∗) gene driven by maize ubiquitin promoter and pCAMBIA1301 harboring hygromycin phosphotransferase gene (hpt) were introduced into Minghui86 (Oryza sativa L. ssp. indica), an elite indica restorer line. Two independent transformants containing both the cry2A(∗) gene and hpt gene were regenerated. Several homozygous marker-free transgenic progenies were derived from family 2AH2, and three of them were selected for further insect bioassay in the laboratory and field...
2016: Frontiers in Plant Science
https://www.readbyqxmd.com/read/27827836/3d-buried-utility-location-using-a-marching-cross-section-algorithm-for-multi-sensor-data-fusion
#13
Qingxu Dou, Lijun Wei, Derek R Magee, Phil R Atkins, David N Chapman, Giulio Curioni, Kevin F Goddard, Farzad Hayati, Hugo Jenks, Nicole Metje, Jennifer Muggleton, Steve R Pennock, Emiliano Rustighi, Steven G Swingler, Christopher D F Rogers, Anthony G Cohn
We address the problem of accurately locating buried utility segments by fusing data from multiple sensors using a novel Marching-Cross-Section (MCS) algorithm. Five types of sensors are used in this work: Ground Penetrating Radar (GPR), Passive Magnetic Fields (PMF), Magnetic Gradiometer (MG), Low Frequency Electromagnetic Fields (LFEM) and Vibro-Acoustics (VA). As part of the MCS algorithm, a novel formulation of the extended Kalman Filter (EKF) is proposed for marching existing utility tracks from a scan cross-section (scs) to the next one; novel rules for initializing utilities based on hypothesized detections on the first scs and for associating predicted utility tracks with hypothesized detections in the following scss are introduced...
November 2, 2016: Sensors
https://www.readbyqxmd.com/read/27823860/contributions-and-source-identification-of-biogenic-and-anthropogenic-hydrocarbons-to-secondary-organic-aerosols-at-mt-tai-in-2014
#14
Yanhong Zhu, Lingxiao Yang, Kimitaka Kawamura, Jianmin Chen, Kaori Ono, Xinfeng Wang, Likun Xue, Wenxing Wang
Ambient fine particulate matter (PM2.5) and volatile organic compounds (VOCs) collected at Mt. Tai in summer 2014 were analysed and the data were used to identify the contribution of biogenic and anthropogenic hydrocarbons to secondary organic aerosols (SOA) and their sources and potential source areas in high mountain regions. Compared with those in 2006, the 2014 anthropogenic SOA tracers in PM2.5 aerosols and VOC species related to vehicular emissions exhibited higher concentrations, whereas the levels of biogenic SOA tracers were lower, possibly due to decreased biomass burning...
January 2017: Environmental Pollution
https://www.readbyqxmd.com/read/27816676/modeling-the-light-induced-electric-potential-difference-%C3%AE-%C3%AE-the-ph-difference-%C3%AE-ph-and-the-proton-motive-force-across-the-thylakoid-membrane-in-c3-leaves
#15
Hui Lyu, Dušan Lazár
A model was constructed which includes electron transport (linear and cyclic and Mehler type reaction) coupled to proton translocation, counter ion movement, ATP synthesis, and Calvin-Benson cycle. The focus is on modeling of the light-induced total electric potential difference (ΔΨ) which in this model originates from the bulk phase electric potential difference (ΔΨb), the localized electric potential difference (ΔΨc), as well as the surface electric potential difference (ΔΨs). The measured dual wavelength transmittance signal (ΔA515-560nm, electrochromic shift) was used as a proxy for experimental ΔΨ...
November 2, 2016: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/27813233/novel-translocation-intermediate-allows-re-evaluation-of-roles-of-atp-proton-motive-force-and-secg-at-the-late-stage-of-preprotein-translocation
#16
Ken-Ichi Nishiyama, Hajime Tokuda
Presecretory proteins such as pOmpA are translocated across the inner membrane of Escherichia coli by Sec translocase powered by ATP and proton motive force (PMF). Translocation activity has been determined by protease protection assaying in vitro. We identified a new translocation intermediate at a late stage, which was protected by proteinase K (PK), but became PK sensitive upon urea extraction. At a late stage of pOmpA translocation driven by PMF in the presence of a nonhydrolyzable ATP analogue, the PK-protected materials arose, but were pulled back upon urea extraction, indicating that completion of translocation requires ATP hydrolysis...
November 4, 2016: Genes to Cells: Devoted to Molecular & Cellular Mechanisms
https://www.readbyqxmd.com/read/27809690/potential-of-mean-force-and-molecular-dynamics-study-on-the-transient-interactions-between-%C3%AE-and-%C3%AE-synuclein-that-drive-inhibition-of-%C3%AE-synuclein-aggregation
#17
Airy Sanjeev, Ravi Kumar Sahu, Venkata Satish Kumar Mattaparthi
Self-association of α-synuclein (αS) into pathogenic oligomeric species and subsequent formation of highly ordered amyloid fibrils is linked to the Parkinson's disease. So most of the recent studies are now focused on the development of potential therapeutic strategies against this debilitating disease. β-synuclein (βS), a presynaptic protein that co-localizes with αS has been recently reported to act as an inhibitor of αS self-assembly. But the specificity of molecular interaction, nature and location between αS/βS is not known despite the potential importance of βS as an inhibitor of αS...
November 21, 2016: Journal of Biomolecular Structure & Dynamics
https://www.readbyqxmd.com/read/27807980/convergence-and-sampling-in-determining-free-energy-landscapes-for-membrane-protein-association
#18
Jan Domanski, George Hedger, Robert B Best, Phillip James Stansfeld, Mark S P Sansom
Potential of mean force (PMF) calculations are used to characterize the free energy landscape of protein-lipid and protein-protein association within membranes. Coarse-grained simulations allow binding free energies to be determined with reasonable statistical error. This accuracy relies on defining a good collective variable describing the binding and unbinding transition, and upon criteria for assessing the convergence of the simulation toward representative equilibrium sampling. As examples, we calculate protein-lipid binding PMFs for ANT/cardiolipin and Kir2...
November 3, 2016: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/27807676/pm2-5-pollution-from-household-solid-fuel-burning-practices-in-central-india-2-application-of-receptor-models-for-source-apportionment
#19
Jeevan Lal Matawle, Shamsh Pervez, Manas Kanti Deb, Anjali Shrivastava, Suresh Tiwari
USEPA's UNMIX, positive matrix factorization (PMF) and effective variance-chemical mass balance (EV-CMB) receptor models were applied to chemically speciated profiles of 125 indoor PM2.5 measurements, sampled longitudinally during 2012-2013 in low-income group households of Central India which uses solid fuels for cooking practices. Three step source apportionment studies were carried out to generate more confident source characterization. Firstly, UNMIX6.0 extracted initial number of source factors, which were used to execute PMF5...
November 2, 2016: Environmental Geochemistry and Health
https://www.readbyqxmd.com/read/27806776/-radical-antegrade-modular-pancreatosplenectomy-procedure-in-pancreatic-body-tail-adenocarcinoma
#20
F Cao, Tdz Oba, Pmf Saiura, F Li
Radical antegrade modular pancreatosplenectomy(RAMPS) has been applied more and more in clinical practice to improve the R0 resection rate in pancreatic body/tail adenocarcinoma.Comparing with traditional procedure, the resection plane in RAMPS is deeper with en-bloc resection of renal fascia, anterior renal fat capsule and even left adrenal gland and regional lymph nodes including No.7, 8, 9, 10, 11p, 11d, partial 14p/d, partial 16a2 and 18.Despite that RAMPS is in favor of improving R0 resection rate, there are many problems about this procedure unsolved and effect on patient survival is still awaited...
November 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
keyword
keyword
90286
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"