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https://www.readbyqxmd.com/read/28711569/the-influence-of-land-use-on-source-apportionment-and-risk-assessment-of-polycyclic-aromatic-hydrocarbons-in-road-deposited-sediment
#1
Jin Zhang, Junwei Wu, Pei Hua, Zhonghua Zhao, Lei Wu, Gongduan Fan, Yun Bai, Thomas Kaeseberg, Peter Krebs
The pollution load of urban runoff is boosted due to the washing away of road-deposited sediment (RDS). Therefore, a source-oriented mitigation strategy is essential to integrated stormwater management. This study showcases the influence of land use dependent source apportionment and risk assessment of polycyclic aromatic hydrocarbons (PAHs) in RDS. Samples were collected from areas of different land uses, including commercial city centre, highway, residential rural and campus areas. According to the positive matrix factorisation (PMF) receptor model, different primary sources were identified at different land use areas...
July 13, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28710830/prognostic-significance-of-a-comprehensive-histologic-evaluation-of-reticulin-fibrosis-collagen-deposition-and-osteosclerosis-in-primary-myelofibrosis-patients
#2
Umberto Gianelli, Stefano Fiori, Daniele Cattaneo, Anna Bossi, Ivan Cortinovis, Arturo Bonometti, Giulia Ercoli, Cristina Bucelli, Nicola Orofino, Gaetano Bulfamante, Alessandra Iurlo
AIMS: to evaluate whether a comprehensive histological evaluation of reticulin fibrosis, collagen deposition and osteosclerosis in bone marrow trephine biopsies (BMBs) of primary myelofibrosis (PMF) patients may have prognostic implications. METHODS: reticulin fibrosis, collagen deposition and osteosclerosis were graded from 0 to 3 in a series of 122 base-line BMBs. Then, we assigned to each case a comprehensive score (RCO score, ranging from 0 to 9) that allowed us to distinguish two groups of patients, with low-grade (RCO score 0-4) and high-grade (RCO score 5-9) stromal changes...
July 15, 2017: Histopathology
https://www.readbyqxmd.com/read/28701157/dacin-one-metalloproteinase-from-deinagkistrodon-acutus-venom-inhibiting-contraction-of-mouse-ileum-muscle
#3
Bin Zhou, Gang Liu, Qiyi He, Bo Li, Xiaodong Yu
BACKGROUND: Mice were bitten by five-pace vipers (Deinagkistrodon acutus), and then envenomed. It was well-known that the snake venom mainly disturbed the blood homeostasis of the envenomed victims. Ocassionally, we found that the venom of D. acutus could inhibit the contraction tension of mouse ileum, so in this study we aimed to identify the active component inhibiting the contraction tension of mouse ileum in the snake venom. RESULTS: The active component inhibiting the contraction tension of mouse ileum, designated as Dacin, was isolated from D...
July 12, 2017: BMC Biochemistry
https://www.readbyqxmd.com/read/28700486/progression-of-primary-myelofibrosis-to-polycythemia-vera-a-case-report
#4
Yan Guo, Wenwei Xu, Lin Dong, Ning Huang, Kehong Bi
RATIONALE: This case report describes the progression of primary myelofibrosis (PMF) to polycythemia vera (PV), and discuss its potential mechanisms. PATIENT CONCERNS: The patient was admitted because of abdominal discomfort and enlarged spleen for 19 months. DIAGNOSIS: A case of PMF progressed to PV was retrospectively analyzed. There were 19 months between the diagnosis of PMF and PV. The JAK2 V617F mutation was positive before and after the diagnosis of PV; however, new chromosomal abnormalities were detected during the progression...
July 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28697595/the-effect-of-a-receding-saline-lake-the-salton-sea-on-airborne-particulate-matter-composition
#5
Alexander L Frie, Justin H Dingle, Samantha C Ying, Roya Bahreini
The composition of ambient particulate matter (PM) and its sources were investigated at the Salton Sea, a shrinking saline lake in California, U.S.A. To investigate the influence of playa exposure on PM composition, PM samples were collected during two seasons and at two sites around the Salton Sea. To characterize source composition, soil samples were collected from local playa and desert surfaces. PM and soil samples were analyzed for 15 elements using mass spectrometry and X-ray diffraction. The contribution of sources to PM mass and composition was investigated using Al-referenced enrichment factors (EFs) and source factors resolved from positive matrix factorization (PMF)...
July 12, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28688466/leukemic-transformation-in-myeloproliferative-neoplasms-a-literature-review-on-risk-characteristics-and-outcome
#6
REVIEW
Meera Yogarajah, Ayalew Tefferi
Myeloproliferative neoplasms (MPNs) operationally include essential thrombocythemia, polycythemia vera, primary myelofibrosis (PMF), and prefibrotic PMF. All 4 MPN variants might progress into blast-phase disease (MPN-BP). For essential thrombocythemia, reported risk factors for leukemic transformation include advanced age, extreme thrombocytosis, anemia, leukocytosis, and sequence variants/mutations involving TP53 and EZH2 (for expansion of gene symbols, see www.genenames.org); for polycythemia vera, advanced age, leukocytosis, abnormal karyotype, mutations involving SRSF2 and IDH2, and treatment with pipobroman, chlorambucil, or P32; and for PMF, increased blast percentage, thrombocytopenia, abnormal karyotype, triple-negative driver mutational status, and sequence variants/mutations involving SRSF2, RUNX1, CEBPA, and SH2B3...
July 2017: Mayo Clinic Proceedings
https://www.readbyqxmd.com/read/28682546/-application-of-muscle-pedicled-platysma-myocutaneous-flap-in-the-reconstruction-of-buccal-mucosa-defects
#7
Huang Long, Jian Xinchun, Chen Xinqun, Su Tong, Jiang Canhua
OBJECTIVE: This study aimed to explore the main features and advantages of the muscle pedicled platysma myocutaneous flap (PMF), the degree of improvement of flap harvest. To evaluate the application value of the flap in the reconstruction of buccal mucosa carcinoma defects. METHODS: Twenty-three patients received PMF with MacFee incision to reconstruct buccal mucosa defects that were caused by the resection of precancer lesions and benign and malignant tumors from August 2012 to April 2015...
April 1, 2017: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28680069/magnetic-field-sensor-based-on-a-combination-of-a-microfiber-coupler-covered-with-magnetic-fluid-and-a-sagnac-loop
#8
Fangfang Wei, Arun Kumar Mallik, Dejun Liu, Qiang Wu, Gang-Ding Peng, Gerald Farrell, Yuliya Semenova
This paper proposes a novel magnetic field sensor based on a microfiber coupler (MFC) combined with a magnetic fluid (MF) in a Sagnac loop formed from a polarization maintaining fiber (PMF). Thanks to the small (~2.6 μm) waist diameter of the MFC, the resulting interference is strongly influenced by the presence of the MF and this leads to the desirable high sensitivity of the structure to the applied magnetic field. The maximum magnetic field sensitivities of -100 pm/mT and -488 pm/mT have been experimentally demonstrated with the PMF lengths of 75 cm and 20 cm respectively in the range of magnetic field strengths from 0 to 200 mT...
July 5, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28675035/pairwise-hydrophobicity-at-low-temperature-appearance-of-a-stable-second-solvent-separated-minimum-with-possible-implication-in-cold-denaturation
#9
Sridip Parui, Biman Jana
The hydrophobic effect appears to be a key driving force for many chemical and biological processes, such as protein folding, protein-protein interactions, membrane bilayer self-assembly, and so forth. In this study, we calculated the potential of mean force (PMF) using umbrella sampling technique between different model hydrophobes (methane-methane, cyclobutane-cyclobutane, and between two rodlike hydrophobes) at lower than ambient temperatures (300, 260, and 240 K). We find the appearance of a second solvent-separated minimum at ∼1...
July 17, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28667628/energy-requirements-for-protein-secretion-via-the-flagellar-type-iii-secretion-system
#10
Marc Erhardt
Protein transport across the cytoplasmic membrane is coupled to energy derived from adenosine triphosphate hydrolysis or the protein motive force (pmf). A sophisticated, multi-component type III secretion system exports substrate proteins of both the bacterial flagellum and virulence-associated injectisome system of many Gram-negative pathogens. The type-III secretion system is primarily a pmf-driven protein exporter. Here, I describe methods to investigate the export of substrate proteins into the culture supernatant under conditions that manipulate the pmf...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28665988/oxidative-stress-induced-in-e-coli-by-the-human-antimicrobial-peptide-ll-37
#11
Heejun Choi, Zhilin Yang, James C Weisshaar
Antimicrobial peptides (AMPs) are thought to kill bacterial cells by permeabilizing their membranes. However, some antimicrobial peptides inhibit E. coli growth more efficiently in aerobic than in anaerobic conditions. In the attack of the human cathelicidin LL-37 on E. coli, real-time, single-cell fluorescence imaging reveals the timing of membrane permeabilization and the onset of oxidative stress. For cells growing aerobically, a CellROX Green assay indicates that LL-37 induces rapid formation of oxidative species after entry into the periplasm, but before permeabilization of the cytoplasmic membrane (CM)...
June 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28664565/relaxation-of-cellular-k-gradients-by-valinomycin-induces-diatoxanthin-accumulation-in-cyclotella-meneghiniana-cells-and-alters-fcpa-fluorescence-yield-in-vitro
#12
Rana Adeel Ahmad, Lars Dietzel
Regulation of photosynthetic light harvesting involves all major thylakoid membrane complexes. One important factor is the proton motive force (pmf) driving ATP production. Its ΔpH component regulates the high energy quenching. Potassium ions largely contribute to the formation of the electric field (ΔΨ). ΔΨ and ΔpH partially compensate each other to form pmf. Whilst in plants considerable progress has been made in analyzing the interplay of H(+) and K(+) gradients, in diatoms knowledge in this field is still scarce...
June 29, 2017: Physiologia Plantarum
https://www.readbyqxmd.com/read/28648047/high-contribution-of-nonfossil-sources-to-submicrometer-organic-aerosols-in-beijing-china
#13
Yanlin Zhang, Hong Ren, Yele Sun, Fang Cao, Yunhua Chang, Shoudong Liu, Xuhui Lee, Konstantinos Agrios, Kimitaka Kawamura, Di Liu, Lujie Ren, Wei Du, Zifa Wang, André S H Prévôt, Sönke Szidat, Pingqing Fu
Source apportionment of organic carbon (OC) and elemental carbon (EC) from PM1 (particulate matter with a diameter equal to or smaller than 1 μm) in Beijing, China was carried out using radiocarbon ((14)C) measurement. Despite a dominant fossil-fuel contribution to EC due to large emissions from traffic and coal combustion, nonfossil sources are dominant contributors of OC in Beijing throughout the year except during the winter. Primary emission was the most important contributor to fossil-fuel derived OC for all seasons...
July 7, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28647252/source-apportionment-of-perfluoroalkyl-substances-in-surface-sediments-from-lakes-in-jiangsu-province-china-comparison-of-three-receptor-models
#14
Yanjie Qi, Zhuoshi He, Shouliang Huo, Jingtian Zhang, Beidou Xi, Shibin Hu
Receptor models have been proved as useful tools to identify source categories and quantitatively calculate the contributions of extracted sources. In this study, sixty surface sediment samples were collected from fourteen lakes in Jiangsu Province, China. The total concentrations of C4-C14-perfluoroalkyl carboxylic acids and perfluorooctane sulfonic acid (∑12PFASs) in sediments ranged from 0.264 to 4.44ng/gdw (dry weight), with an average of 1.76ng/gdw. Three commonly-applied receptor models, namely principal component analysis-multiple linear regression (PCA-MLR), positive matrix factorization (PMF) and Unmix models, were employed to apportion PFAS sources in sediments...
July 2017: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28639360/the-mechanism-of-coupling-between-oxido-reduction-and-proton-translocation-in-respiratory-chain-enzymes
#15
Sergio Papa, Giuseppe Capitanio, Francesco Papa
The respiratory chain of mitochondria and bacteria is made up of a set of membrane-associated enzyme complexes which catalyse sequential, stepwise transfer of reducing equivalents from substrates to oxygen and convert redox energy into a transmembrane protonmotive force (PMF) by proton translocation from a negative (N) to a positive (P) aqueous phase separated by the coupling membrane. There are three basic mechanisms by which a membrane-associated redox enzyme can generate a PMF. These are membrane anisotropic arrangement of the primary redox catalysis with: (i) vectorial electron transfer by redox metal centres from the P to the N side of the membrane; (ii) hydrogen transfer by movement of quinones across the membrane, from a reduction site at the N side to an oxidation site at the P side; (iii) a different type of mechanism based on co-operative allosteric linkage between electron transfer at the metal redox centres and transmembrane electrogenic proton translocation by apoproteins...
June 21, 2017: Biological Reviews of the Cambridge Philosophical Society
https://www.readbyqxmd.com/read/28629701/a-polymethoxyflavone-mixture-extracted-from-orange-peels-mainly-containing-nobiletin-3-3-4-5-6-7-8-heptamethoxyflavone-and-tangeretin-suppresses-melanogenesis-through-the-acidification-of-cell-organelles-including-melanosomes
#16
Norihiro Yoshizaki, Ron Hashizume, Hitoshi Masaki
BACKGROUND: Skin color is determined by melanin contents and its distribution. Melanin is synthesized in melanosomes of melanocytes, catalyzed by tyrosinase, melanogenic enzymes. Regarding the process of melanin synthesis, melanosomal pH is considered to play an important role, because it has been reported to differ between Caucasian and Black melanocytes. OBJECTIVE: Although polymethoxyflavone (PMF) has many beneficial effects, it has not been reported which PMF suppresses melanogenesis...
June 10, 2017: Journal of Dermatological Science
https://www.readbyqxmd.com/read/28622624/primary-myelofibrosis-older-age-and-high-jak2v617f-allele-burden-are-associated-with-elevated-plasma-high-sensitivity-c-reactive-protein-levels-and-a-phenotype-of-progressive-disease
#17
Giovanni Barosi, Margherita Massa, Rita Campanelli, Gabriela Fois, Paolo Catarsi, Gianluca Viarengo, Laura Villani, Valentina Poletto, Tiziana Bosoni, Umberto Magrini, Robert P Gale, Vittorio Rosti
We measured plasma levels of high-sensitivity C-reactive protein (hs-CRP) in 526 subjects with primary myelofibrosis (PMF). Thirty-eight percent had an elevated hs-CRP level (≥0.3mg/dL). Elevated hs-CRP levels were associated with a progressive disease phenotype, including anemia, high white blood cell count, low platelet count, increased splenomegaly, increased risk of blast transformation, and worse survival. Age≥52years, but no other demographic characteristics, was associated with an elevated hs-CRP level in multivariable logistic regression (odds ratio [OR], 4...
June 7, 2017: Leukemia Research
https://www.readbyqxmd.com/read/28620109/prefibrotic-early-vs-overt-pmf
#18
(no author information available yet)
No abstract text is available yet for this article.
June 15, 2017: Blood
https://www.readbyqxmd.com/read/28620103/pre-pmf-emerging-as-important-subgroup-of-mpn
#19
Heinz Gisslinger
No abstract text is available yet for this article.
June 15, 2017: Blood
https://www.readbyqxmd.com/read/28615140/imaging-features-of-myeloproliferative-neoplasms
#20
REVIEW
I G Murphy, E L Mitchell, L Raso-Barnett, A L Godfrey, E M Godfrey
Myeloproliferative neoplasms (MPNs) are a heterogeneous group of haematological disorders including polycythaemia vera (PV), essential thrombocythaemia (ET), primary myelofibrosis (PMF), and chronic myeloid leukaemia (CML). These disorders show large overlap in genetic and clinical presentations, and can have many different imaging manifestations. Unusual thromboses, embolic events throughout the systemic or pulmonary vasculature, or osseous findings can often be clues to the underlying disease. There is limited literature about the imaging features of these disorders, and this may result in under-diagnosis...
June 11, 2017: Clinical Radiology
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