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https://www.readbyqxmd.com/read/28237549/il-37-increased-in-patients-with-acute-coronary-syndrome-and-associated-with-a-worse-clinical-outcome-after-st-segment-elevation-acute-myocardial-infarction
#1
Kun Liu, Qiang Tang, Xinyuan Zhu, Xinchun Yang
BACKGROUND: IL-37 emerges as a natural suppressor of inflammatory responses. The potential role of IL-37 in the pathology of atherosclerosis is unclear. The purpose of this study was to assess IL-37 profile in acute coronary syndrome (ACS) and the prognostic role of this cytokine in patients with ST-segment elevation acute myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PPCI). METHODS: In a case-control study, we prospectively enrolled 216 patients undergoing the first coronary angiography, which consisted of 5 groups: normal (n=57), stable angina (SAP, n=36), unstable angina (UAP, n=42), non-STEMI (n=36), STEMI (n=45)...
February 22, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28212919/thrombus-composition-in-sudden-cardiac-death-from-acute-myocardial-infarction
#2
Johanne Silvain, Jean-Philippe Collet, Paul Guedeney, Olivier Varenne, Chandrasekaran Nagaswami, Carole Maupain, Jean-Philippe Empana, Chantal Boulanger, Muriel Tafflet, Stephane Manzo-Silberman, Mathieu Kerneis, Delphine Brugier, Nicolas Vignolles, John W Weisel, Xavier Jouven, Gilles Montalescot, Christian Spaulding
BACKGROUND AND AIM: It was hypothesized that the pattern of coronary occlusion (thrombus composition) might contribute to the onset of ventricular arrhythmia and sudden cardiac death (SCD) in myocardial infarction (MI). METHODS: The TIDE (Thrombus and Inflammation in sudden DEath) study included patients with angiographically-proven acute coronary occlusion as the cause of a ST elevation MI (STEMI) complicated by Sudden Cardiac Death (SCD group) or not (STEMI group)...
February 14, 2017: Resuscitation
https://www.readbyqxmd.com/read/28155873/alteration-of-multiple-leukocyte-gene-expression-networks-is-linked-with-magnetic-resonance-markers-of-prognosis-after-acute-st-elevation-myocardial-infarction
#3
A Teren, H Kirsten, F Beutner, M Scholz, L M Holdt, D Teupser, M Gutberlet, J Thiery, G Schuler, I Eitel
Prognostic relevant pathways of leukocyte involvement in human myocardial ischemic-reperfusion injury are largely unknown. We enrolled 136 patients with ST-elevation myocardial infarction (STEMI) after primary angioplasty within 12 h after onset of symptoms. Following reperfusion, whole blood was collected within a median time interval of 20 h (interquartile range: 15-25 h) for genome-wide gene expression analysis. Subsequent CMR scans were performed using a standard protocol to determine infarct size (IS), area at risk (AAR), myocardial salvage index (MSI) and the extent of late microvascular obstruction (lateMO)...
February 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28144260/the-rs2228145-polymorphism-in-the-interleukin-6-receptor-and-its-association-with-long-term-prognosis-after-myocardial-infarction-in-a-pilot-study
#4
Anna Szpakowicz, Witold Pepinski, Ewa Waszkiewicz, Małgorzata Skawronska, Anna Niemcunowicz-Janica, Wlodzimierz J Musial, Karol A Kaminski
INTRODUCTION: Interleukin-6 (IL-6) is a cytokine with a complex function that is described as both pro- and anti-inflammatory. One factor that influences its function is the rs2228145 A/C single nucleotide polymorphism (SNP) of the IL-6 receptor (IL6R) gene. C allele carriers have a decreased inflammatory response and decreased prevalence of ischemic heart disease. The aim of the study was to investigate the association of the rs2228145 SNP of the IL6R gene with long-term total mortality in patients with ST-elevation myocardial infarction (STEMI) treated invasively...
February 1, 2017: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/28110894/endothelial-function-after-st-elevation-myocardial-infarction-in-patients-with-high-levels-of-high-sensitivity-crp-and-lp-pla2-a-substudy-of-the-response-randomized-trial
#5
Jasveen J Kandhai-Ragunath, Bjorn de Wagenaar, Cees Doelman, Jan van Es, Harald T Jørstad, Ron J G Peters, Carine J M Doggen, Clemens von Birgelen
BACKGROUND: The combination of high levels of high-sensitive C-reactive protein (hs-CRP) and lipoprotein-associated phospholipase-A2 (Lp-PLA2) was recently shown to correlate with increased cardiovascular risk. Endothelial dysfunction is also known to be a risk factor for cardiovascular events. AIM: To test among patients with previous ST-elevation myocardial infarction (STEMI) the hypothesis that high levels of both hs-CRP and Lp-PLA2 may be associated with impaired endothelium-dependent vasodilatation...
January 2, 2017: Cardiovascular Revascularization Medicine: Including Molecular Interventions
https://www.readbyqxmd.com/read/28105343/increased-complements-and-high-sensitivity-c-reactive-protein-predict-heart-failure-in-acute-myocardial-infarction
#6
Danni Liu, Xin Qi, Qi Li, Wenjun Jia, Liping Wei, Anan Huang, Keqiang Liu, Zongjin Li
The aim of the present study was to investigate whether the serum levels of complements and high-sensitivity C-reactive protein (hs-CRP) in patients with acute myocardial infarction (AMI) are associated with the severity of myocardial injury. Consecutive patients (n=110) with AMI and 33 healthy individuals, who served as control subjects, were enrolled from May 2013 to February 2015. These patients were divided into two groups, those with ST segment elevation MI (STEMI) and those with non-ST segment elevation MI (NSTEMI)...
December 2016: Biomedical Reports
https://www.readbyqxmd.com/read/28105138/clinical-and-angiographic-correlation-of-high-sensitivity-c-reactive-protein-with-acute-st-elevation-myocardial-infarction
#7
Syed Tanveer, Shaheena Banu, Nasimudeen Rehumathbeevi Jabir, Mohd Shahnawaz Khan, Ghulam Md Ashraf, Nanjappa Cholenahally Manjunath, Shams Tabrez
Vascular inflammation and associated ongoing inflammatory responses are considered as the critical culprits in the pathogenesis of acute atherothrombotic events such as acute coronary syndrome (ACS) and myocardial infarction (MI). ST segment elevation myocardial infarction (STEMI) is considered as one of the prominent clinical forms of ACS. Moreover, C-reactive protein (CRP) is an important acute phase prsotein, which may be estimated using high-sensitivity methods (hs-CRP), and its elevated level in body fluids reflects chronic inflammatory status...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28094123/myocardial-and-serum-galectin-3-expression-dynamics-marks-post-myocardial-infarction-cardiac-remodelling
#8
Umesh C Sharma, Wassim Mosleh, Milind R Chaudhari, Rujuta Katkar, Brian Weil, Chris Evelo, Thomas R Cimato, Saraswati Pokharel, W Matthijs Blankesteijn, Gen Suzuki
BACKGROUND: Acute myocardial infarction (MI) causes significant changes in cardiac morphology and function. Galectin-3 is a novel and potentially therapeutically important mediator of cardiac remodelling. Myocardial and serum galectin-3 expression dynamics in response to the early cardiovascular outcomes after acute MI are not fully elucidated. METHODS: We first performed a comprehensive longitudinal microarray analyses in mice after acute MI. We then measured the serum levels of galectin-3 in a translational porcine model of coronary microembolism-induced post-ischaemic cardiac remodelling...
December 19, 2016: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28089413/relation-of-st-segment-elevation-myocardial-infarction-to-daily-ambient-temperature-and-air-pollutant-levels-in-a-japanese-nationwide-percutaneous-coronary-intervention-registry
#9
Kyohei Yamaji, Shun Kohsaka, Takeshi Morimoto, Kenshi Fujii, Tetsuya Amano, Shiro Uemura, Takashi Akasaka, Kazushige Kadota, Masato Nakamura, Takeshi Kimura
Effects of daily fluctuation of ambient temperature and concentrations of air pollutants on acute cardiovascular events have not been well studied. From January 2011 to December 2012, a total of 56,863 consecutive ST-segment elevation myocardial infarction (STEMI) patients who underwent primary percutaneous coronary intervention were registered from 929 institutes with median interinstitutional distance of 2.6 km. We constructed generalized linear mixed models in which the presence or absence of patients with STEMI per day per institute was included as a binomial response variable, with daily meteorologic and environmental data obtained from their respective observatories nearest to the institutes (median distance of 9...
March 15, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28065445/colin-trial-value-of-colchicine-in-the-treatment-of-patients-with-acute-myocardial-infarction-and-inflammatory-response
#10
Mariama Akodad, Benoît Lattuca, Nicolas Nagot, Vera Georgescu, Mathilde Buisson, Jean-Paul Cristol, Florence Leclercq, Jean-Christophe Macia, Richard Gervasoni, Thien-Tri Cung, Stéphane Cade, Frédéric Cransac, Jessica Labour, Anne-Marie Dupuy, François Roubille
BACKGROUND: Inflammation is involved during acute myocardial infarction, and could be an interesting target to prevent ischaemia-reperfusion injuries. Colchicine, known for its pleiotropic anti-inflammatory effects, could decrease systemic inflammation in this context. AIMS: To evaluate the impact of colchicine on inflammation in patients admitted for ST-segment elevation myocardial infarction (STEMI). METHODS: All patients admitted for STEMI with one of the main coronary arteries occluded, and successfully treated with percutaneous coronary intervention, were included consecutively...
January 3, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28006953/lymphocyte-communication-in-myocardial-ischemia-reperfusion-injury
#11
Stephen E Boag, Emanuele Andreano, Ioakim Spyridopoulos
SIGNIFICANCE: Myocardial ischaemia/reperfusion (I/R) is an important complication of reperfusion therapy for myocardial infarction. It is a complex process involving metabolic and immunological factors. To date no effective treatment has been identified. Recent Advances: Previous research has focused on the role of innate immune cells in I/R injury. In recent years increasing evidence has accumulated for an important role for adaptive immune cells, particularly T lymphocytes. Data from ST elevation myocardial infarction (STEMI) patients has identified prognostic significance for lymphocyte counts, particularly post-reperfusion lymphopenia...
December 23, 2016: Antioxidants & Redox Signaling
https://www.readbyqxmd.com/read/28004756/alteration-of-platelet-gpvi-signaling-in-st-elevation-myocardial-infarction-patients-demonstrated-by-a-combination-of-proteomic-biochemical-and-functional-approaches
#12
Paula Vélez, Raymundo Ocaranza-Sánchez, Diego López-Otero, Lilian Grigorian-Shamagian, Isaac Rosa, Esteban Guitián, José María García-Acuña, José Ramón González-Juanatey, Ángel García
The platelet-specific collagen receptor glycoprotein VI (GPVI) is critical for the formation of arterial thrombosis in vivo. We analyzed GPVI-activated platelets from ST-elevation myocardial infarction (STEMI) patients and matched stable coronary artery disease (SCAD) controls in order to provide novel clues on the degree of involvement of GPVI signaling in the acute event. Firstly, platelets were isolated from systemic venous blood and activated with the GPVI specific agonist CRP (collagen-related peptide)...
December 22, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27968766/indications-for-fibrinolysis-in-patients-with-st-segment-elevation-myocardial-infarction-from-guidelines-to-practice
#13
C Boivineau, L Orion, J Dimet, E Boiffard
BACKGROUND: European guidelines on managing ST segment elevation myocardial infarction (STEMI) during the first 12hours recommend fibrinolysis when the time elapsing between the first medical contact and balloon time (FMCBT) is more than 120minutes. AIM: To assess the real-life clinical efficacy of guidelines on fibrinolysis in managing STEMI and identify obstacles to their everyday implementation. METHODS: An observational study based on a permanent registry of reperfusion strategies and timing among patients treated in a French general hospital for STEMI with chest pain lasting for less than two hours...
November 2016: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/27921405/thrombolytic-therapy-up-regulates-inflammatory-mediators-compared-to-percutaneous-coronary-intervention-pci
#14
Alireza Garjani, Bahram Sohrabi, Ali Akbar Movassaghpour, Sina Andalib, Mehriar Shokri, Bahar Taherkhanchi, Bahador Bagheri
The important role of reperfusion therapies in the treatment of acute myocardial infarction is well documented. However, reperfusion therapies can initiate inflammatory response and may damage the myocardium. The purpose of current study was to compare the effects of percutaneous coronary intervention and thrombolytic therapy on inflammatory markers in the setting of ST elevation myocardial infarction (STEMI). Eighty three patients with STEMI were enrolled in this study. 40 patients underwent percutaneous coronary intervention (PCI), and 43 patients received streptokinase (1...
August 2016: Iranian Journal of Allergy, Asthma, and Immunology
https://www.readbyqxmd.com/read/27866132/a-tool-for-predicting-the-outcome-of-reperfusion-in-st-elevation-myocardial-infarction-using-age-thrombotic-burden-and-index-of-microcirculatory-resistance-ati-score
#15
Giovanni Luigi De Maria, Gregor Fahrni, Mohammad Alkhalil, Florim Cuculi, Sam Dawkins, Mathias Wolfrum, Robin P Choudhury, John C Forfar, Bernard D Prendergast, Tuncay Yetgin, Robert Jan van Geuns, Matteo Tebaldi, Keith M Channon, Rajesh K Kharbanda, Peter M Rothwell, Marco Valgimigli, Adrian P Banning
AIMS: Restoration of effective myocardial reperfusion by primary percutaneous coronary intervention (PPCI) in patients with ST-elevation myocardial infarction is difficult to predict. A method to assess the likelihood of a suboptimal response to conventional pharmacomechanical therapies could be beneficial. We aimed to derive and validate a scoring system that can be used acutely at the time of coronary reopening to predict the likelihood of downstream microvascular impairment in patients with STEMI...
November 20, 2016: EuroIntervention
https://www.readbyqxmd.com/read/27821850/a-comparative-metabolomics-approach-reveals-early-biomarkers-for-metabolic-response-to-acute-myocardial-infarction
#16
Sara E Ali, Mohamed A Farag, Paul Holvoet, Rasha S Hanafi, Mohamed Z Gad
Discovery of novel biomarkers is critical for early diagnosis of acute coronary syndrome (ACS). Serum metabolite profiling of ST-elevation myocardial infarction (STEMI), unstable angina (UA) and healthy controls was performed using gas chromatography mass spectrometry (GC/MS), solid-phase microextraction coupled to gas chromatography mass spectrometry (SPME-GC/MS) and nuclear magnetic resonance ((1)H-NMR). Multivariate data analysis revealed a metabolic signature that could robustly discriminate STEMI patients from both healthy controls and UA patients...
November 8, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27756477/pooled-analysis-comparing-the-efficacy-of-intracoronary-versus-intravenous-abciximab-in-smokers-versus-nonsmokers-undergoing-primary-percutaneous-coronary-revascularization-for-acute-st-elevation-myocardial-infarction
#17
Raffaele Piccolo, Gennaro Galasso, Ingo Eitel, Alberto Dominguez-Rodriguez, Allan Zeeberg Iversen, Youlan L Gu, Pedro Abreu-Gonzalez, Bart J G L de Smet, Giovanni Esposito, Stephan Windecker, Holger Thiele, Federico Piscione
Cigarette smokers with ST-segment elevation myocardial infarction (STEMI) may present different response to potent antithrombotic therapy compared to nonsmokers. We assessed the impact of smoking status and intracoronary abciximab in patients with STEMI undergoing primary percutaneous coronary intervention (PCI). We pooled data from 5 randomized trials comparing intracoronary versus intravenous abciximab bolus in patients undergoing primary PCI. The primary end point was the composite of death or reinfarction at a mean follow-up of 292 ± 138 days...
September 13, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27749762/infectious-complications-and-immune-inflammatory-response-in-cardiogenic-shock-patients-a-prospective-observational-study
#18
Jiri Parenica, Jiri Jarkovsky, Jan Malaska, Alexandre Mebazaa, Jana Gottwaldova, Katerina Helanova, Jiri Litzman, Milan Dastych, Josef Tomandl, Jindrich Spinar, Ludmila Dostalova, Petr Lokaj, Marie Tomandlova, Monika Goldergova Pavkova, Pavel Sevcik, Matthieu Legrand
INTRODUCTION: Patients with cardiogenic shock (CS) are at a high risk of developing infectious complications; however, their early detection is difficult, mainly due to a frequently occurring noninfectious inflammatory response, which accompanies an extensive myocardial infarction (MI) or a postcardiac arrest syndrome. The goal of our prospective study was to describe infectious complications in CS and the immune/inflammatory response based on a serial measurement of several blood-based inflammatory biomarkers...
February 2017: Shock
https://www.readbyqxmd.com/read/27543480/no-reflow-phenomenon-in-percutaneous-coronary-interventions-in-st-segment-elevation-myocardial-infarction
#19
REVIEW
Sanjiv Gupta, Madan Mohan Gupta
Percutaneous coronary intervention (PCI) is effective in opening the infarct related artery and restoring thrombolysis in myocardial infarction flow 3 (TIMI-flow 3) in large majority of ST-elevation myocardial infarction (STEMI). However there remain a small but significant proportion of patients, who continue to manifest diminished myocardial reperfusion despite successful opening of the obstructed epicardial artery. This phenomenon is called no-reflow. Clinically it manifests with recurrence of chest pain and dyspnea and may progress to cardiogenic shock, cardiac arrest, serious arrhythmias and acute heart failure...
July 2016: Indian Heart Journal
https://www.readbyqxmd.com/read/27543440/doppler-echocardiographic-myocardial-stunning-index-predicts-recovery-of-left-ventricular-systolic-function-after-primary-percutaneous-coronary-intervention
#20
Dawod Sharif, Wisam Matanis, Amal Sharif-Rasslan, Uri Rosenschein
BACKGROUND: Myocardial stunning is responsible for partially reversible left ventricular (LV) systolic dysfunction after successful primary percutaneous coronary intervention (PPCI) in patients with acute ST-elevation myocardial infarction (STEMI). AIM: To test the hypothesis that early coronary blood flow (CBF) to LV systolic function ratios, as an equivalent to LV stunning index (SI), predict recovery of LV systolic function after PPCI in patients with acute STEMI...
October 2016: Echocardiography
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