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Stemi response

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https://www.readbyqxmd.com/read/29743973/apoptosis-and-mobilization-of-lymphocytes-to-cardiac-tissue-is-associated-with-myocardial-infarction-in-a-reperfused-porcine-model-and-infarct-size-in-post-pci-patients
#1
Maria J Forteza, Isabel Trapero, Arantxa Hervas, Elena de Dios, Amparo Ruiz-Sauri, Gema Minana, Clara Bonanad, Cristina Gómez, Ricardo Oltra, Cesar Rios-Navarro, Daniel F J Ketelhuth, Julio Nunez, Francisco J Chorro, Vicente Bodi
ST-segment elevation myocardial infarction (STEMI) is the most severe outcome of coronary artery disease. Despite rapid reperfusion of the artery, acute irrigation of the cardiac tissue is associated with increased inflammation. While innate immune response in STEMI is well described, an in-depth characterization of adaptive immune cell dynamics and their potential role remains elusive. We performed a translational study using a controlled porcine reperfusion model of STEMI and the analysis of lymphocyte subsets in 116 STEMI patients undergoing percutaneous coronary intervention (PCI)...
2018: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/29739432/emergency-management-of-patients-with-st-segment-elevation-myocardial-infarction-in-eastern-austria-a-descriptive-quality-control-study
#2
Helmut Trimmel, Thomas Bayer, Wolfgang Schreiber, Wolfgang G Voelckel, Lukas Fiedler
BACKGROUND: Myocardial infarction is a time-critical condition and its outcome is determined by appropriate emergency care. Thus we assessed the efficacy of a supra-regional ST-segment elevation myocardial infarction (STEMI) network in Easternern Austria. METHODS: The Eastern Austrian STEMI network serves a population of approx. 766.000 inhabitants within a region of 4186 km2 . Established in 2007, it now comprises 20 pre-hospital emergency medical service (EMS) units (10 of these physician-staffed), 4 hospitals and 3 cardiac intervention centres...
May 9, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29620476/association-of-pre-admission-statin-therapy-and-the-inflammatory-response-in-st-elevation-myocardial-infarction-patients
#3
Zach Rozenbaum, Dor Ravid, Gilad Margolis, Shafik Khoury, Natalia Kaufman, Gad Keren, Assi Milwidsky, Yacov Shacham
PURPOSE: To demonstrate the possible association of statin therapy with C reactive protein (CRP) serial measurements in ST elevation myocardial infarction (STEMI) patients. MATERIALS AND METHODS: STEMI patients between 2008 and 2016 with available CRP data from admission were divided into two groups according to pre-admission statin therapy. A second CRP measurement was noted following primary coronary intervention (within 24 hours from admission). The difference between the two measurements was designated ΔCRP...
April 5, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29589674/reperfusion-in-stemi-patients-still-a-role-for-cardioprotection
#4
Filippo Ottani, Ugo Limbruno, Roberto Latini, Leonardo Misuraca, Marcello Galvani
Ischemic heart disease remains a leading cause of death worldwide, responsible for an estimated 17.5 million deaths in 2012. Mortality from St-elevation myocardial infarction STEMI have decreased over the last 3 decades. However, despite the success of reperfusion therapy by primary percutaneous coronary intervention (PPCI) or thrombolysis, STEMI is still of significant concern. A recent patient-level meta-analysis emphasized the pivotal importance of infarct size within 1 month after PPCI as a determinant of all-cause mortality and hospitalization for heart failure at 1 year...
March 28, 2018: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/29568338/daily-land-use-regression-estimated-woodsmoke-and-traffic-pollution-concentrations-and-the-triggering-of-st-elevation-myocardial-infarction-a-case-crossover-study
#5
David Q Rich, Mark J Utell, Daniel P Croft, Sally W Thurston, Kelly Thevenet-Morrison, Kristin A Evans, Frederick S Ling, Yilin Tian, Philip K Hopke
Prior work has reported acute associations between ST-elevation myocardial infarction (STEMI) and short-term increases in airborne particulate matter. Subsequently, the association between STEMI and hourly measures of Delta-C (marker of woodsmoke) and black carbon (marker of traffic pollution) measured at a central site in Rochester, NY, were examined, but no association was found. Therefore, land use regression estimates of Delta-C and black carbon concentrations at each patient's residence were developed for 246 STEMI patients treated at the University of Rochester Medical Center during the winters of 2008-2012...
2018: Air Quality, Atmosphere, & Health
https://www.readbyqxmd.com/read/29548521/the-utility-of-the-triage-electrocardiogram-for-the-detection-of-st-segment-elevation-myocardial-infarction
#6
Samantha Noll, Heidi Alvey, Namita Jayaprakash, Aniruddha Paranjpe, Joseph Miller, Michele L Moyer, Richard Nowak
INTRODUCTION: Current AHA/ACC guidelines on the management of ST-elevation myocardial infarction (STEMI) suggest that an ECG is indicated within 10minutes of arrival for patients arriving to the Emergency Department (ED) with symptoms concerning for STEMI. In response, there has been a creep towards performing ECGs more frequently in triage. The objectives of this study were to quantify the number of triage ECGs performed at our institution, assess the proportion of ECGs performed within current hospital guidelines, and evaluate the rate of STEMI detection in triage ECGs...
February 3, 2018: American Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29541845/serial-assessment-of-endothelial-function-1-6-and-12-months-after-st-elevation-myocardial-infarction
#7
Jasveen J Kandhai-Ragunath, Carine J M Doggen, Liefke C van der Heijden, Marlies M Kok, Paolo Zocca, Bjorn de Wagenaar, Cees Doelman, Harald T Jørstad, Ron J G Peters, Clemens von Birgelen
Knowledge about the changes in endothelial function after ST-elevation myocardial infarction (STEMI) is of substantial interest, but serial data are scarce. The aim of the present study was to noninvasively evaluate whether endothelial function, as assessed shortly after primary percutaneous coronary intervention (PPCI) for STEMI, may improve until 12-month follow-up. This prospective observational cohort study was performed in patients in the RESPONSE randomized trial who participated in a substudy and underwent noninvasive assessment of endothelial function at 1 (baseline), 6, and 12-month follow-up after treatment of a STEMI by PPCI...
March 14, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29455776/confronting-system-barriers-for-st-elevation-mi-in-low-and-middle-income-countries-with-a-focus-on-india
#8
Sameer Mehta, Christopher Granger, Cindy Lee Grines, Alice Jacobs, Timothy D Henry, Ivan Rokos, Alexandra Lansky, Andreas Baumbach, Roberto Botelho, Alexandra Ferre, Isaac Yepes, Roopa Salwan, Jamshed Dalal, Jitendra Makkar, Neeraj Bhalla, Sundeep Mishra, Vinod Vijan, Shirish Hiremath
Our previous research found seven specific factors that cause system delays in ST-elevation Myocardial infarction management in developing countries. These delays, in conjunction with a lack of organized STEMI systems of care, result in inefficient processes to treat AMI in developing countries. In our present opinion paper, we have specifically explored the three most pertinent causes that afflict the seven specific factors responsible for system delays. In doing so, we incorporated a unique strategy of global STEMI expertise...
January 2018: Indian Heart Journal
https://www.readbyqxmd.com/read/29398672/low-dose-erythropoietin-in-patients-with-st-segment-elevation-myocardial-infarction-epo-ami-ii-a-randomized-controlled-clinical-trial
#9
Tetsuo Minamino, Shuichiro Higo, Ryo Araki, Shungo Hikoso, Daisaku Nakatani, Hiroshi Suzuki, Takahisa Yamada, Masaaki Okutsu, Kouji Yamamoto, Yasushi Fujio, Yoshio Ishida, Takuya Ozawa, Kiminori Kato, Ken Toba, Yoshifusa Aizawa, Issei Komuro
BACKGROUND: Erythropoietin (EPO) has antiapoptotic and tissue-protective effects, but previous clinical studies using high-dose EPO have not shown cardioprotective effects, probably because of platelet activation and a lack of knowledge regarding the optimal dose. In contrast, a small pilot study using low-dose EPO has shown improvement in left ventricular function without adverse cardiovascular events.Methods and Results:We performed a multicenter (25 hospitals), prospective, randomized, double-blind, placebo-controlled, dose-finding study to clarify the efficacy and safety of low-dose EPO in patients with ST-segment elevation myocardial infarction (STEMI) under the Evaluation System of Investigational Medical Care of the Ministry of Health, Labor and Welfare of Japan...
March 23, 2018: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/29384954/the-dose-response-association-between-estimated-glomerular-filtration-rate-and-prognosis-of-patients-with-st-segment-elevation-myocardial-infarction-from-rural-areas-of-china-s-liaoning-province
#10
MULTICENTER STUDY
Guangxiao Li, Guoxian Qi, Bo Zhang, Bo Zhou, Bing Ma, Daming Jiang, Qiao He, Cong Ai, Huixu Dai, Ying Li, Jingpu Shi
We aimed to investigate the dose-response associations between chronic kidney disease (CKD), and short and long-term cardiovascular outcomes, to characterize these associations by drawing dose-response curves based on a Chinese rural ST-segment elevation myocardial infarction (STEMI) population.In all, 1067 patients with STEMI were consecutively enrolled from 12 secondary hospitals of China's Liaoning province (from June 2009 to June 2010 and January 2015 to December 2015). The follow-up was regularly performed by telephone...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29318464/early-vascular-responses-to-everolimus-eluting-cobalt-chromium-stent-in-the-culprit-lesions-of-st-elevation-myocardial-infarction-results-from-a-multicenter-prospective-optical-coherence-tomography-study-mechanism-ami-2-week-follow-up-study
#11
Yoshihiro Morino, Daisuke Terashita, Hiromasa Otake, Tatsuo Kikuchi, Tetsuya Fusazaki, Nehiro Kuriyama, Takahide Suzuki, Yoshiaki Ito, Kiyoshi Hibi, Hiroyuki Tanaka, Shozo Ishihara, Toru Kataoka, Takashi Morita, Yoritaka Otsuka, Takatoshi Hayashi, Kengo Tanabe, Toshiro Shinke
The use of cobalt-chromium everolimus-eluting stents (CoCr-EES) for ST-segment elevation myocardial infarction (STEMI) reduces the incidence of stent thrombosis compared with bare metal stents, and a substantial difference is apparent in the initial 2 weeks. However, vascular behavior during this early period remains unclear. This was a prospective study (MECHANISM-AMI-2W) to investigate early vascular responses in STEMI patients immediately after CoCr-EES implantation and at 2-week follow-up using frequency domain-optical coherence tomography (FD-OCT)...
January 9, 2018: Cardiovascular Intervention and Therapeutics
https://www.readbyqxmd.com/read/29260275/analysis-of-the-cyp2c19-genotype-associated-with-bleeding-in-serbian-stemi-patients-who-have-undergone-primary-pci-and-treatment-with-clopidogrel
#12
Mirjana Novkovic, Dragan Matic, Jelena Kusic-Tisma, Nebojsa Antonijevic, Dragica Radojkovic, Ljiljana Rakicevic
PURPOSE: Bleeding is one of the possible adverse events during clopidogrel therapy. The CYP2C19 gene is the most significant genetic factor which influences response to clopidogrel treatment. We aimed to examine the contribution of the CYP2C19 gene to bleeding occurrence during clopidogrel therapy in Serbian patients with ST segment elevation myocardial infarction (STEMI) undergoing primary percutaneous coronary intervention (PCI). METHODS: This case-control study included 53 patients who experienced bleeding and 55 patients without bleeding...
April 2018: European Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29239074/barriers-to-the-use-of-emergency-medical-services-for-st-elevation-myocardial-infarction-determining-why-many-patients-opt-for-self-transport
#13
Mathew Mercuri, Katherine Connolly, Madhu K Natarajan, Michelle Welsford, J D Schwalm
RATIONALE, AIMS, AND OBJECTIVES: Access to timely ST-elevation myocardial infarction (STEMI) care is facilitated by paramedics and emergency medical services (EMS). However, a large proportion of STEMI patients do not access care through EMS. This study sought to identify patient-reported factors for their decision to use (or not use) EMS. METHODS: Semi-structured interviews were conducted with a sample of STEMI patients admitted to a large tertiary care centre between November 2011 and January 2012...
December 13, 2017: Journal of Evaluation in Clinical Practice
https://www.readbyqxmd.com/read/29237337/key-interventions-and-quality-indicators-for-quality-improvement-of-stemi-care-a-rand-delphi-survey
#14
Daan Aeyels, Peter R Sinnaeve, Marc J Claeys, Sofie Gevaert, Danny Schoors, Walter Sermeus, Massimiliano Panella, Ellen Coeckelberghs, Luk Bruyneel, Kris Vanhaecht
OBJECTIVE: Identification, selection and validation of key interventions and quality indicators for improvement of in hospital quality of care for ST-elevated myocardial infarction (STEMI) patients. METHODS AND RESULTS: A structured literature review was followed by a RAND Delphi Survey. A purposively selected multidisciplinary expert panel of cardiologists, nurse managers and quality managers selected and validated key interventions and quality indicators prior for quality improvement for STEMI...
December 13, 2017: Acta Cardiologica
https://www.readbyqxmd.com/read/29198986/australian-trends-in-procedural-characteristics-and-outcomes-in-patients-undergoing-percutaneous-coronary-intervention-for-st-elevation-myocardial-infarction
#15
Sinjini Biswas, Stephen J Duffy, Jeffrey Lefkovits, Nick Andrianopoulos, Angela Brennan, Antony Walton, William Chan, Samer Noaman, James A Shaw, Luke Dawson, Andrew Ajani, David J Clark, Melanie Freeman, Chin Hiew, Ernesto Oqueli, Christopher M Reid, Dion Stub
Over the last decade, systems of care for ST-elevation myocardial infarction (STEMI) have evolved to try to improve outcomes and timely access to percutaneous coronary intervention (PCI). There have also been advances in PCI techniques and adjunctive pharmacotherapies. In this study, we sought to determine temporal changes in practices and clinical outcomes of PCI in patients with STEMI. We prospectively collected data on 8,412 consecutive patients undergoing PCI for STEMI between 2005 and 2016 in the multicenter Melbourne Interventional Group registry...
February 1, 2018: American Journal of Cardiology
https://www.readbyqxmd.com/read/29155384/first-serial-optical-coherence-tomography-assessment-at-baseline-12-and-24-months-in-stemi-patients-treated-with-the-second-generation-absorb%C3%A2-bioresorbable-vascular-scaffold
#16
Janusz Kochman, Koltowski Łukasz, Mariusz Tomaniak, Jacek Jąkała, Klaudia Proniewska, Jacek Legutko, Tomasz Roleder, Arkadiusz Piertrasik, Adam Rdzanek, Wacław Kochman, Salvatore Brugaletta, Grzegorz Opolski, Evelyn Regar
AIMS: The aim of the study was to assess the vascular healing response after Absorb bioresorbable vascular scaffold (BVS) implantation in patients with ST segment elevation myocardial infarction (STEMI) utilizing truly serial optical coherence tomography (OCT) examination at baseline, 12- and 24-months. METHODS AND RESULTS: This is the single-centre, prospective, longitudinal study with baseline, 12- and 24-month OCT evaluation of 18 STEMI patients treated with 22 Absorb BVS implantation...
November 21, 2017: EuroIntervention
https://www.readbyqxmd.com/read/29095267/elevated-plasma-levels-of-interleukin-16-in-patients-with-acute-myocardial-infarction
#17
Christiana Schernthaner, Vera Paar, Bernhard Wernly, Rudin Pistulli, Ilonka Rohm, Christian Jung, Hans-Reiner Figulla, Attila Yilmaz, Janne Cadamuro, Elisabeth Haschke-Becher, P Christian Schulze, Uta C Hoppe, Michael Lichtenauer, Daniel Kretzschmar
Interleukin (IL)-16, a polypeptide cytokine, plays a crucial role in the inflammatory process, acting as a chemoattractant for peripheral immune cells and has been linked to various inflammatory diseases. However, its role in patients with acute myocardial infarction (AMI) is unclear.We retrospectively analyzed serum levels of IL-16 in blood of patients with (STEMI, n = 45) and without ST-segment elevation myocardial infarction (NSTEMI, n = 42) compared with controls with excluded coronary artery disease (n = 55)...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29035427/differences-in-the-korea-acute-myocardial-infarction-registry-compared-with-western-registries
#18
REVIEW
Doo Sun Sim, Myung Ho Jeong
The Korea Acute Myocardial Infarction Registry (KAMIR) is the first nationwide registry that reflects current therapeutic approaches and acute myocardial infarction (AMI) management in Korea. The results of the KAMIR demonstrated different risk factors and responses to medical and interventional treatments. The results indicated that the incidence of ST-elevation myocardial infarction (STEMI) was relatively high, and that the prevalence of dyslipidemia was relatively low with higher triglyceride and lower high-density lipoprotein cholesterol levels...
November 2017: Korean Circulation Journal
https://www.readbyqxmd.com/read/29020248/relationship-between-microvascular-obstruction-and-adverse-events-following-primary-percutaneous-coronary-intervention-for-st-segment-elevation-myocardial-infarction-an-individual-patient-data-pooled-analysis-from-seven-randomized-trials
#19
Suzanne de Waha, Manesh R Patel, Christopher B Granger, E Magnus Ohman, Akiko Maehara, Ingo Eitel, Ori Ben-Yehuda, Paul Jenkins, Holger Thiele, Gregg W Stone
Aims: Microvascular obstruction (MVO) is the underlying cause for the no-reflow phenomenon in ST-segment elevation myocardial infarction (STEMI). The association between MVO assessed by cardiac magnetic resonance imaging (CMR) and prognosis has not been convincingly demonstrated. We sought to determine the relationship between MVO assessed early after primary percutaneous coronary intervention (PCI) in STEMI and all-cause mortality, hospitalization for heart failure (HF), and reinfarction...
December 14, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28984467/the-9p21-rs-1333040-polymorphism-is-associated-with-coronary-microvascular-obstruction-in-st-segment-elevation-myocardial-infarction-treated-by-primary-angioplasty
#20
Francesco Fracassi, Giampaolo Niccoli, Vincenzo Vetrugno, Michele Cauteruccio, Antonino Buffon, Ilaria Gatto, Igor Giarretta, Paolo Tondi, Roberto Pola, Filippo Crea
BACKGROUND: Microvascular obstruction (MVO) after primary percutaneous coronary intervention (pPCI) leads to higher incidence of both early and late complications. A number of single nucleotide polymorphisms in 9p21 chromosome have been shown to affect angiogenesis in response to ischaemia. In particular, Rs1333040 with its three genotypic vriants C/C, T/C and T/T might influence the occurrence of MVO after pPCI. METHODS: We enrolled ST-elevation myocardial infarction (STEMI) patients undergoing pPCI...
October 1, 2017: European Heart Journal. Acute Cardiovascular Care
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