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Heavy metal poison

Evangelos Zoidis, Isidoros Seremelis, Nikolaos Kontopoulos, Georgios P Danezis
Unlike other essential trace elements that interact with proteins in the form of cofactors, selenium (Se) becomes co-translationally incorporated into the polypeptide chain as part of 21st naturally occurring amino acid, selenocysteine (Sec), encoded by the UGA codon. Any protein that includes Sec in its polypeptide chain is defined as selenoprotein. Members of the selenoproteins family exert various functions and their synthesis depends on specific cofactors and on dietary Se. The Se intake in productive animals such as chickens affect nutrient utilization, production performances, antioxidative status and responses of the immune system...
May 14, 2018: Antioxidants (Basel, Switzerland)
Janka Vašková, Klára Krempaská, Daniel Žatko, Pavol Mudroň, Gabriela Glinská, Ladislav Vaško
Chronic exposure to lead causes disruption to energy production mechanisms and tissue damage, in particular through its binding to thiol groups and competition for zinc binding sites. We investigated the possibility of preventing the consequences of chronic lead poisoning by administration of three different doses of humic acids (HAs) into feed with the aim of establishing an effective HA dose. During the 10-week experiment, a sub-lethal dose of lead acetate was given to rats during the first 5 weeks, with continuous administration of HA over 10 weeks...
May 10, 2018: Biological Trace Element Research
Monika Kofroňová, Petra Mašková, Helena Lipavská
This review provides insights into As toxicity in plants with focus on photosynthesis and sugar metabolism as important arsenic targets and simultaneously defence tools against accompanying oxidative stress. Heavy metal contamination is a great problem all over the world. Arsenic, a metalloid occurring naturally in the Earth's crust, also massively spreads out in the environment by human activities. Its accumulation in crops poses a severe health risk to humans and animals. Besides the restriction of human-caused contamination, there are two basic ways how to cope with the problem: first, to limit arsenic accumulation in harvestable parts of the crops; second, to make use of some arsenic hyperaccumulating plants for phytoremediation of contaminated soils and waters...
May 7, 2018: Planta
Shuang-Shuang Chen, Jing Jiang, Xiao-Jiao Han, Yun-Xing Zhang, Ren-Ying Zhuo
Sedum alfredii Hance, a cadmium (Cd)/zinc (Zn)/lead (Pb) co-hyperaccumulating species, is a promising phytoremediation candidate because it accumulates substantial amounts of heavy metal ions without showing any obvious signs of poisoning. The heat shock transcription factor (Hsf) family plays crucial roles in plant growth, development, and stress responses. Although the roles of some Hsfs in abiotic stress have been well studied in model plants, the Hsf family has not been systematically investigated in heavy metal hyperaccumulators...
April 17, 2018: International Journal of Molecular Sciences
Cyrus S H Ho, Roger C M Ho, Amy M L Quek
Heavy metal poisoning is a rare but important cause of encephalopathy. Manganese (Mn) toxicity is especially rare in the modern world, and clinicians’ lack of recognition of its neuropsychiatric manifestations can lead to misdiagnosis and mismanagement. We describe the case of a man who presented with recurrent episodes of confusion, psychosis, dystonic limb movement and cognitive impairment and was initially diagnosed with anti-voltage-gated potassium channel (VGKC) complex limbic encephalitis in view of previous positive autoantibodies...
April 18, 2018: International Journal of Environmental Research and Public Health
Chaffy Sachdeva, Kshema Thakur, Aditi Sharma, Krishan Kumar Sharma
The documentation of lead toxicity (plumbism) dates back to the times when man learnt its various applications. This versatile heavy metal is non-degradable and its ability to get accumulated in the body that goes undiagnosed, makes it a serious environmental health hazard. Lead is now known to affect almost every organ/tissue of the human body. With irreversible effects on neurobiological development of young children and foetus, its toxicity has lasting implications on the human life. Outlining the symptoms, diagnosis and treatment therapy for lead poisoning, the present review elaborates the pathophysiological effects of lead on various organs...
April 2018: Indian Journal of Clinical Biochemistry: IJCB
Gianni Gallello, Elisabetta Cilli, Fulvio Bartoli, Massimo Andretta, Lucio Calcagnile, Agustin Pastor, Miguel de la Guardia, Patrizia Serventi, Alberto Marino, Stefano Benazzi, Giorgio Gruppioni
Giovanni Pico della Mirandola and Angelo Poliziano were two of the most important humanists of the Italian Renaissance. They died suddenly in 1494 and their deaths have been for centuries a subject of debate. The exhumation of their remains offered the opportunity to study the cause of their death through a multidisciplinary research project. Anthropological analyses, together with documentary evidences, radiocarbon dating and ancient DNA analysis supported the identification of the remains attributed to Pico...
March 28, 2018: Journal of Forensic and Legal Medicine
Ozlem Kar Kurt, Dilek Ergun, Nursen Basaran
BACKGROUND: Work-related asthma (WRA) constitutes a significant proportion of all asthma cases and continues to be reported from different industries. The aim of the study was to identify the occupations that can be related to WRA and diagnostic steps used in suspected WRA patients. METHODS: We retrospectively reviewed the clinical records of WRA suspected patients who were referred to Ankara Occupational and Environmental Diseases Hospital, Turkey from January 2015 to January 2017...
April 2018: Respiratory Medicine
Can Li, Ze-Min Ni, Lin-Xiang Ye, Jian-Wei Chen, Qi Wang, Yi-Kai Zhou
BACKGROUND: Lead is a heavy metal that can affect the human hematological system. However, reports are limited on the dose-response relationship between blood lead levels (BLLs) and hematological parameters in children. This study aimed to explore the dose-response relationship between BLLs and hematological measurements among children in China. METHODS: A cross-sectional design was used. A total of 743 children aged 5-8 years were recruited from two counties in central China...
March 27, 2018: Environmental Research
Razzagh Mahmoudi, Bahareh Rahimi, Parviz Hassanzadeh, Peyman Ghajarbeygi, Babak Pakbin
Background: The topic of food safety has become a major public health issue worldwide. Over recent decades, the growing concern for food safety has brought about greater research regarding the risks associated with the consumption of produce that has been contaminated by pesticides, heavy metals and/or toxins. Objective: The study was conducted to determine the concentration of Pb in the muscle of buffalos slaughtered in the northwest regions of Iran (Ardabil, Urmia and Tabriz cities)...
January 2018: Electronic Physician
Zichao Wang, Libo Yang, Jianrong Wu, Hongtao Zhang, Li Zhu, Xiaobei Zhan
Xanthan gum is commonly used as thickener in food industry, while the usage of xanthan gum as dietary fiber is restricted for its low additive volume. Herein, the potential use of a low-viscosity and high-transparency xanthan gum as dietary fiber was evaluated in vitro . This new xanthan shows better transparency and faster dissolution rate than most commercial products, and its viscosity increases along with the treatment of freeze-thaw cycles at -20 °C. Moreover, this new xanthan can absorb heavy metals (Pb, Cd, Cu) and retard starch digestion by glucoamylase...
March 22, 2018: Preparative Biochemistry & Biotechnology
Pramod Kushwah, Abhishek Yadav, S J S Flora
Chelation therapy is the mainstream treatment for heavy metal poisoning. Apart from this, therapy using antioxidant/herbal extracts are the other strategies now commonly being tried for the treatment. We have previously reported individual beneficial efficacy of nanoparticle mediated administration of an antioxidant like 'curcumin' and an arsenic chelator 'monoisoamyl 2,3-dimercaptosuccinic acid (MiADMSA)' for the treatment of arsenic toxicity compared to bulk drugs. The present paper investigates our hypothesis that a combination drug delivery therapy employing two nanosystems, a chelator and a strong antioxidant, may produce more pronounced therapeutic effects compared to individual effects in the treatment of arsenic toxicity...
March 13, 2018: Chemico-biological Interactions
L Xueting, M U Rehman, H Zhang, X Tian, X Wu, Shixue, K Mehmood, D Zhou
The valuable role of selenium in mitigation of oxidative stress and heavy metal toxicity is well-known. Thus, the aim of the current study on broiler chickens was to examine whether nano elemental selenium (Nano-Se) supplementation can reduce the effects of chromium VI (K2Cr2O7) toxicity. For this purpose, a total of 150, one-day-old broiler chickens were allotted to five groups with three replicates: control group (standard diet), poisoned group (K2Cr2O7 via drinking water), protection group (K2Cr2O7 + Nano- Se), cure group (K2Cr2O7 for initial 2 weeks and then Nano-Se), and prevention group (opposite to the cure group)...
January 2018: Journal of Biological Regulators and Homeostatic Agents
Iara Dantas de Souza, Abraão Silveira de Andrade, Rodrigo Juliani Siqueira Dalmolin
Lead is an important heavy metal used worldwide in several applications, especially in industry. People exposed to lead can develop a wide range of symptoms associated with lead poisoning. Many effects of lead poisoning are reported in the literature, showing a compromising of whole body health, with symptoms related to cardiovascular, immune, bone, reproductive, hematological, renal, gastrointestinal, and nervous system. However, the molecular lead targets as well as the pathways affected by lead poisoning are not completely described...
May 2018: Critical Reviews in Toxicology
Hadeel Saeed Al-Maliki, Suceti Martinez, Patrick Piszczatowski, Joan W Bennett
Drosophila melanogaster is a useful model organism that offers essential insights into developmental and cellular processes shared with humans, which has been adapted for large scale analysis of medically important microbes and to test the toxicity of heavy metals, industrial solvents and other poisonous substances. We here give a brief review of the use of the Drosophila model in medical mycology, discuss the volatile organic compounds (VOCs) produced by the opportunistic human pathogen, Aspergillus fumigatus , and give a brief summary of what is known about the toxicity of some common fungal VOCs...
December 2017: Mycobiology
Sharon Iron-Segev, Janerose Nasimiyu Lusweti, Elizabeth Kamau-Mbuthia, Aliza H Stark
OBJECTIVE: Geophagia, the deliberate consumption of rocks, soil, or clay, is prevalent in developing countries, particularly sub-Saharan Africa. Health risks associated with this behavior include parasitosis, heavy metal poisoning, nutrient deficiencies, and poor birth outcomes. This pilot study was designed to reduce geophagic practices and improve nutrition among rural Kenyan women. METHODS: The researchers used snowball sampling to recruit participants (n = 135; aged 15-49 years) from low socioeconomic areas who consumed geophagic materials...
December 22, 2017: Journal of Nutrition Education and Behavior
Adrienn Grúz, János Déri, Géza Szemerédy, Korinna Szabó, Éva Kormos, András Bartha, József Lehel, Péter Budai
Concentrations of different heavy metals (As, Cd, Cr, Cu, Hg, Pb, Zn) were examined in the contour feathers of long-eared owl (Asio otus), little owl (Athene noctua), tawny owl (Strix aluco), barn owl (Tyto alba), Eurasian sparrowhawk (Accipiter nisus), rook (Corvus frugilegus), hooded crow (Corvus cornix), carrion crow (Corvus corone), common buzzard (Buteo buteo) and barn swallow (Hirundo rustica). The samples were collected from the Hortobágyi Madárpark (Bird Hospital Foundation) in Hungary. The bird species were classified into six groups based on their nourishment...
March 2018: Environmental Science and Pollution Research International
Chang Tian, Martina A Doblin, Katherine A Dafforn, Emma L Johnston, Haiyan Pei, Wenrong Hu
There is growing public concern about the global expansion of harmful algal bloom species (HABs), with dinoflagellate microalgae comprising the major portion of the harmful taxa. These motile, unicellular organisms have a lifecycle involving sexual reproduction and resting cyst formation whereby cysts can germinate from sediments and 'seed' planktonic populations. Thus, investigation of dinoflagellate cyst (dinocyst) distribution in sediments can provide significant insights into HAB dynamics and contribute to indices of habitat quality...
February 2018: Environmental Science and Pollution Research International
C J M Poole, S Basu
Background: The waste and recycling sector is a growing part of industry. Whether health surveillance is indicated and how it should be undertaken is unclear. Aims: To undertake a review of the literature to identify hazards to health, biological effects and occupational illnesses for workers in the sector. Methods: A systematic review of the published literature and two UK databases. Results: Rates of fatal, non-fatal injuries and self-reported work-related illness were found to be higher in the waste and recycling sector than in UK industry as a whole...
December 2, 2017: Occupational Medicine
Maurya Khushboo, Meesala Krishna Murthy, Maibam Sunita Devi, Sanasam Sanjeev, Kalibulla Syed Ibrahim, Nachimuthu Senthil Kumar, Vikas Kumar Roy, Guruswami Gurusubramanian
Copper is a persistent toxic and bio-accumulative heavy metal of global concern. Continuous exposure of copper compounds of different origin is the most common form of copper poisoning and in turn adversely altering testis morphology and function and affecting sperm quality. L-carnitine has a vital role in the spermatogenesis, physiology of sperm, sperm production and quality. This study was designed to examine whether the detrimental effects of long-term copper consumption on sperm quality and testis function of Wistar albino rat could be prevented by L-carnitine therapy...
January 2018: Environmental Science and Pollution Research International
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