Neurosychology

The problem to evaluate treatment outcome in adult PKU (phenylketonuric) patients lies in the heterogeneity of the adult PKU population. This heterogeneity is not only based on the different treatment history of every individual patient but also on the different severity of the underlying defect of the enzyme phenylalanine hydroxylase. Recent, partly double blind studies in adult PKU patients further support recommendation for lifelong treatment. However, it has become evident that dietary treatment is suboptimal and continuation to adulthood often not accepted...

One of the most difficult problems in the rehabilitation of patients with closed-head injuries is posed by executive function disturbances, that is, difficulty in making the transition from thinking to acting. This article presents the working hypotheses and a description of a rehabilitation program developed by the authors, oriented directly towards training executive functions, in contract to the existing standard program, based on physical therapy with the addition of neuropsychological exercises directed towards training particular cognitive functions...

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