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Jessica Schweitzer, Jennifer Vermeesch, Theresa Zaleski, Megan Iacco, Kent Krach, Jessica Ghaferi, Jenny Cotton
No abstract text is available yet for this article.
September 2016: JAAD Case Reports
Seung-Hee Loh, Yu-Jin Oh, Bark-Lynn Lew, Woo-Young Sim
No abstract text is available yet for this article.
October 2016: Annals of Dermatology
Keisuke Goto
BACKGROUND: This study was designed to evaluate the immunoexpression of DOG1, a specific marker expressed in gastrointestinal stromal tumors, in normal skin tissues and cutaneous epithelial tumors. METHODS: DOG1 immunostaining extent, intensity and pattern were evaluated in 69 cutaneous apocrine/eccrine tumors, 11 sebaceous tumors, 46 follicular tumors, 52 keratinocytic tumors and perilesional normal tissues. RESULTS: In normal tissues, DOG1 was expressed strongly in the intercellular canaliculi of eccrine glands, moderately in the myoepithelial cells of mammary and anogenital mammary-like glands, and weakly or not at all in the periphery of sebaceous lobules and the lower layer of epidermis and follicular infundibulum...
November 2016: Journal of Cutaneous Pathology
Nicola di Meo, Giuseppe Stinco, Alessandro Gatti, Mattia Fadel, Silvia Vichi, Giusto Trevisan
Dear Editor, Apocrine hidradenoma is a rare benign adnexal tumor related to the more common poroma, as they both originate from sweat glands. Hidradenoma usually has an eccrine differentiation, but an apocrine differentiation is possible. Due to its rarity and non-specific clinical appearance it is difficult to differentiate it from other malignant cutaneous lesions. In this challenging task, dermatoscopy could be particularly helpful to better describe, recognize, and differentiate these lesions. Unfortunately, the literature offers only few dermatoscopic descriptions of this rare cutaneous neoplasm...
June 2016: Acta Dermatovenerologica Croatica: ADC
Mami Fukasawa-Momose, Munenari Itoh, Keigo Ito, Yoshimasa Nobeyama, Hidemi Nakagawa
No abstract text is available yet for this article.
December 1, 2016: European Journal of Dermatology: EJD
A Udvardi, B Mayer, B Volc-Platzer, A Rütten
Primary cutaneous cribriform apocrine carcinoma is a distinctive but little known variant of cutaneous apocrine carcinoma with indolent biological behaviour. It should not be mistaken for a cutaneous metastasis of a visceral carcinoma, an adenoid cystic basal cell carcinoma or a primary cutaneous adenoid cystic carcinoma.
September 2016: Der Hautarzt; Zeitschrift Für Dermatologie, Venerologie, und Verwandte Gebiete
Marta Kogut, Ferdinand Toberer, Alexander H Enk, Jessica C Hassel
BACKGROUND: Diagnostic differentiation between Bowen disease a variant of squamous cell carcinoma in situ (SCCIS) and basal cell carcinoma (BCC) can be difficult on the basis of hematoxylin and eosin (routine) staining in small or fragmented biopsy samples. Ber-EP4 staining is diagnostically reliable for differentiation between BCC and cutaneous squamous cell carcinoma [Dasgeb et al. Biomark Cancer, 5: 7, (2013); Tellechea et al. Am J Dermatopathol, 15: 452 (1993)]. The objective of this study was to determine the usefulness of Ber-EP4 staining for differentiation of SCCIS from BCC...
April 2016: Journal of Cutaneous Pathology
Carina M Woodruff, Abbas M Charlie, Kieron S Leslie
Hidradenitis suppurativa is a chronic inflammatory disease of apocrine gland-bearing skin. Although immunologic derangements, genetic predisposition, obesity, and smoking are likely important factors, the pathogenesis of the disease and the effect of available treatments on disease course have not been fully elucidated. In the absence of proper treatment, chronic inflammation results in diffuse scarring and a wide array of complications, including the development of cutaneous squamous cell carcinoma. This severe and chronic disease can have detrimental effects on self-esteem and quality of life...
December 2015: Mayo Clinic Proceedings
Richard B Mertens, Mariza N de Peralta-Venturina, Bonnie L Balzer, David P Frishberg
Initial investigations reported GATA3 to be a sensitive and relatively specific marker for mammary and urothelial carcinomas. Recently, GATA3 expression has been described in several other epithelial tumors. However, there has been only limited investigation of GATA3 expression in cutaneous epithelial tumors. The objective of this study was to examine the immunohistochemical expression of GATA3 in a wide variety of cutaneous epithelial neoplasms. GATA3 expression was evaluated in 99 benign and 63 malignant cutaneous epithelial tumors...
December 2015: American Journal of Dermatopathology
Daniel H Miller, Jennifer L Peterson, Steven J Buskirk, Laura A Vallow, Randy Ta, Richard Joseph, Murli Krishna, Stephen J Ko, Katherine S Tzou
Hidradenocarcinoma is a rare aggressive form of cutaneous adnexal skin carcinoma originating from the sweat gland. Due to its low incidence, prognostic and treatment strategies are still being explored both for primary and advanced disease. This tumor most often presents as either solid or cystic appearing subcutaneous nodules, which may be associated with pruritus or ulceration. To date the mainstay of treatment for local disease has been surgical excision; however, the paucity of historical data available has shown that these tumors often behave aggressively with high rates of local recurrence, metastasis, and poor overall outcomes...
September 7, 2015: Rare Tumors
Ashok Y Kshirsagar, J V Wader, Basavaraj Nagur, Sangeeta Biradar, Jigneshkumar Savsaviya, Trishant Chotai, Aman Agarwal
INTRODUCTIONS: Sweat gland carcinoma is very rare with a reported incidence of less than 0.005% of all tumour specimens resected surgically (Tulenko and Conway, 1965) [1]. CASE REPORT: A sixty year old male patient presented to us with a solitary swelling over the left chest wall since two months. DISCUSSION: Cutaneous apocrine gland carcinoma, a subtype of sweat gland carcinoma, is a very rare malignant neoplasm arising in areas of high apocrine sweat gland density...
2015: International Journal of Surgery Case Reports
Kyung-Jin Seo, Jae-Jun Kim
Primary cutaneous apocrine gland carcinoma, which is a type of sweat gland carcinoma, is an extremely rare type of cancer. Clinical courses of this type of cancer usually progress slowly but can, occasionally, be associated with rapid progression. This case report describes a 53-year-old Korean man with primary cutaneous apocrine gland carcinoma that arose from an apocrine gland in the areola tissue. The patient visited our hospital because of a large, painful chest wall mass beneath the right nipple. The mass had been present for more than eight years but had grown rapidly over the past few months...
2015: Journal of Cardiothoracic Surgery
José C Cardoso, Eduardo Calonje
Cutaneous adnexal tumours can be a diagnostic challenge for the pathologist. This is particularly true in the case of tumours with sweat gland differentiation, due to a large number of rare entities, a multiplicity of names to designate the same neoplasms and consequent lack of consensus regarding their classification and nomenclature. In the traditional view, sweat gland tumours were divided into eccrine and apocrine. However, this has been challenged in recent years, and in fact many of these tumours may have both eccrine and apocrine variants...
November 2015: Histopathology
Yang Li, Li-li Chen, Bin Li, Xiao-ying Tian, Zhi Li
Cutaneous apocrine carcinoma (AC) is a rare adnexal neoplasm that histologically can mimic breast carcinoma metastatic to the skin or apocrine carcinoma arising in ectopic breast tissue. As extremely rare condition, neuroendocrine differentiation may be observed in AC although its etiology and pathogenesis is still unclear. We report here a case of unusual AC with neuroendocrine differentiation in right labium majus pudenda. A 43-year-old woman presented with a 6-month history of an asymptomatic pea-sized brownish nodule in right labium majus pudenda without enlargement of inguinal lymph nodes and bilateral breast nodules...
2015: Diagnostic Pathology
In Ho Choi, Sangchul Yun
Primary cutaneous apocrine carcinoma is a rare adnexal tumor of the skin that occurs mainly in the axilla, anogenital area while the scalp and the lower extremities, especially the thigh, are very unusual sites. However, clinical or pathologic characteristics have not been well established due to a paucity of this tumor. Herein, we report very unusual case of apocrine carcinoma present as a huge mass in the lateral thigh of 77-year-old woman, which was aggravated abruptly after an irritation by moxa treatment, with a brief review of the literature...
May 2015: Annals of Surgical Treatment and Research
Takuya Miyagawa, Takafumi Kadono, Takashi Taniguchi, Kouki Nakamura, Ryosuke Saigusa, Ayumi Yoshizaki, Tomomitsu Miyagaki, Daisuke Yamada, Yuri Masui, Shinichi Sato
Cutaneous apocrine carcinoma (CAC) is a rare malignancy. It develops predominantly in the regions where apocrine glands are distributed. Some cases of CAC have been reported in the axilla and the inguinal regions, but only a few in the scrotum. We herein report a case of CAC which widely spread over both sides of the whole scrotum with plate-like hard induration, and such a manifestation has never been reported before. CAC is known to have high rates of local recurrence or metastasis, and the efficacy of radiotherapy or chemotherapy has not been established...
August 2015: Journal of Dermatology
Keisuke Goto
BACKGROUND: The aim of this study was to evaluate the effectiveness of CD117 immunostaining for diagnosing cutaneous adnexal tumors, which has not been previously established. METHODS: CD117 immunostaining was performed on representative sections of 87 clinicopathologically confirmed cutaneous apocrine/eccrine tumors, 13 sebaceous tumors, 52 follicular tumors, 55 keratinocytic tumors, 24 metastatic tumors of the skin of known origin and 1 mammary Paget disease. Staining of 5-50% of cells was considered focally positive, and staining of 51-100% of cells was considered diffusely positive...
July 2015: Journal of Cutaneous Pathology
Lauro Lourival Lopes Filho, Ione Maria Ribeiro Soares Lopes, Lauro Rodolpho Soares Lopes, Milvia M S S Enokihara, Alexandre Osores Michalany, Nobuo Matsunaga
Paget's disease, described by Sir James Paget in 1874, is classified as mammary and extramammary. The mammary type is rare and often associated with intraductal cancer (93-100% of cases). It is more prevalent in postmenopausal women and it appears as an eczematoid, erythematous, moist or crusted lesion, with or without fine scaling, infiltration and inversion of the nipple. It must be distinguished from erosive adenomatosis of the nipple, cutaneous extension of breast carcinoma, psoriasis, atopic dermatitis, contact dermatitis, chronic eczema, lactiferous ducts ectasia, Bowen's disease, basal cell carcinoma, melanoma and intraductal papilloma...
March 2015: Anais Brasileiros de Dermatologia
Sean Huang, Mark Frydenberg, Alan Pham, Jeremy P Grummet
A 78-year-old man presented with an enlarging, tender mass in the scrotum separate to the testes. This was on the background of radical cystoprostatectomy, urethrectomy, and ileal conduit formation for high-grade urothelial carcinoma of the bladder invading submucosa 3 years prior. Examination revealed a 4 × 5 cm lesion, which was hard, fixed to the overlying skin and nodular to palpation. Ultrasound confirmed a solid mass in the scrotum extending into the perineum. Computerized tomography of the chest, abdomen, and pelvis revealed enlargement of inguinal lymph nodes but no other metastases...
January 2015: Urology Annals
Jingjing Guo, Gang Wu, Jinhua Xu, Zhenyu Ma, Zhongwen Zhou
Cutaneous apocrine carcinoma (CAC) is a rare type of malignant adnexal tumour with only scattered reports. We report a 52-year-old male patient of CAC in groin with bilateral lymph node metastasis. The patient had a left inguinal subcutaneous mass 3 cm × 2 cm in size for 4 years, and received a wide local excision of the tumour. Pathological sectioning suggested CAC. The immunohistochemical staining revealed GCDFP15 (+), 34BE12 (+), ER (+), PR (+), CK7 (+), Ki67 (5%-10%), HER2/Neu (-), P53 (-), P63 (-), and CK20 (-)...
2014: International Journal of Clinical and Experimental Pathology
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