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https://www.readbyqxmd.com/read/28544157/malignancies-in-korean-patients-with-immunoglobulin-g4-related-disease
#1
Sung Soo Ahn, Jason Jungsik Song, Yong-Beom Park, Sang-Won Lee
AIM: Several studies have implicated increased risk of malignancy in patients with immunoglobulin G4-related disease (IgG4-RD). Hence, we first evaluated the risk and the type of malignancy in Korean IgG4-RD patients. METHOD: Clinical and laboratory results of patients fulfilling the comprehensive diagnostic criteria for IgG4-RD were retrospectively collected between January 2006 and November 2015. One hundred and eighteen patients were included, and 35 were classified as having definite, 83 as possible/probable IgG4-RD...
May 22, 2017: International Journal of Rheumatic Diseases
https://www.readbyqxmd.com/read/28540606/diagnostic-performances-of-serum-igg4-concentration-and-igg4-igg-ratio-in-igg4-related-disease
#2
Chang-Sheng Xia, Chun-Hong Fan, Yan-Ying Liu
Patients with IgG4-related disease (IgG4-RD) often have elevated serum IgG4 levels. Here, we aimed to evaluate the diagnostic performances of elevated serum IgG4 concentration and IgG4/IgG ratio for IgG4-RD. We retrospectively analyzed 1381 patients subjected to serum IgG subclass testing to differentiate IgG4-RD from other diseases at Peking University People's Hospital from 2012 to 2016. This sample included 133 IgG4-RD patients and 1248 non-IgG4-RD patients. Serum IgG subclass concentrations were measured using Siemens reagents...
May 24, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28535184/maternal-zika-virus-disease-severity-virus-load-prior-dengue-antibodies-and-their-relationship-to-birth-outcomes
#3
U A Halai, K Nielsen-Saines, M E Moreira, P C Sequeira, J P Pereira Junior, A A Zin, J D Cherry, C R Gabaglia, S L Gaw, K Adachi, I Tsui, J H Pilotto, R M Ribeiro Nogueira, A M Bispo de Filippis, P Brasil
Background: Congenital Zika virus (ZIKV) syndrome is a newly identified condition resulting from infection during pregnancy. We analyzed outcome data from a mother-infant cohort in Rio de Janeiro in order to assess whether clinical severity of maternal ZIKV infection was associated with maternal virus load, prior dengue antibodies or abnormal pregnancy/infant outcomes. Methods: A clinical severity assessment tool was developed based on duration of fever, severity of rash, multisystem involvement and duration of symptoms during ZIKV infection...
May 23, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/28534223/immunoglobulin-m-gene-association-with-autoantibody-reactivity-and-type-1-diabetes
#4
Inês Rolim, Nádia Duarte, Gabriela Barata, João Costa, Luís Gardete-Correia, José Boavida, Rui Duarte, João Raposo, Zulmira Peerally, Manuela Catarino, Carlos Penha-Gonçalves
Several lines of evidence show that autoimmune responses evolving in type 1 diabetes (T1D) patients include the generation of multi-reactive autoantibody (AutoAb) repertoires, but their role in T1D pathogenesis remains elusive. We tested the hypothesis that variants at the immunoglobulin heavy chain (IGH) locus are genetic determinants of AutoAbs against pancreatic antigens and contribute to T1D susceptibility. With this aim, two independent study designs were used: a case-control study and a family-based cohort comprising a total of 240 T1D patients, 172 first-degree relatives (mother and/or father), and 130 unrelated healthy controls living in Portugal...
May 22, 2017: Immunogenetics
https://www.readbyqxmd.com/read/28531224/defining-the-vaccination-window-for-respiratory-syncytial-virus-rsv-using-age-seroprevalence-data-for-children-in-kilifi-kenya
#5
Joyce U Nyiro, Ivy K Kombe, Charles J Sande, James Kipkoech, Patience K Kiyuka, Clayton O Onyango, Patrick K Munywoki, Timothy M Kinyanjui, D James Nokes
BACKGROUND: Respiratory syncytial virus (RSV) is an important cause of lower respiratory tract disease in early life and a target for vaccine prevention. Data on the age-prevalence of RSV specific antibodies will inform on optimizing vaccine delivery. METHODS: Archived plasma samples were randomly selected within age strata from 960 children less than 145 months of age admitted to Kilifi County Hospital pediatric wards between 2007 and 2010. Samples were tested for antibodies to RSV using crude virus IgG ELISA...
2017: PloS One
https://www.readbyqxmd.com/read/28528009/identification-of-novel-haemophilus-parasuis-serovar-5-vaccine-candidates-using-an-immunoproteomic-approach
#6
Gang Li, Fang Xie, Jianjun Li, Jiao Liu, Dapeng Li, Yanhe Zhang, Paul R Langford, Yanwen Li, Siguo Liu, Chunlai Wang
Haemophilus parasuis is the aetiological agent of Glässer's disease, which is responsible for cases of fibrinous polyserositis, polyarthritis and meningitis. No vaccine is known that provides cross-protection against all serovars. The identification of novel immunoprotective antigens would undoubtedly contribute to the development of efficient subunit vaccines. In the present study, an immunoproteomic approach was used to analyze secreted proteins of H. parasuis and six proteins with high immunogenicity were identified...
May 17, 2017: Journal of Proteomics
https://www.readbyqxmd.com/read/28527268/-seroprevalence-and-risk-factors-of-cysticercosis-in-two-rural-communities-in-anzo%C3%A3-tegui-state-venezuela
#7
Manuel Toquero, Antonio Morocoima, Elizabeth Ferrer
INTRODUCTION: Cysticercosis is caused by Taenia solium cysticerci, which are located mainly in the central nervous system causing neurocysticercosis. In Venezuela, few epidemiological studies on this disease have been conducted. OBJECTIVE: To determine the seroprevalence and risk factors for cysticercosis in two rural communities in Anzoátegui state. MATERIAL AND METHODS: We conducted a survey to collect data on possible risk factors and signs and symptoms of the disease, and we took 182 samples in two communities, Boquerón and Punto Lindo...
April 1, 2017: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/28526790/post-epizootic-persistence-of-asymptomatic-mycoplasma-conjunctivae-infection-in-iberian-ibex
#8
Xavier Fernández-Aguilar, Oscar Cabezón, José Enrique Granados, Joachim Frey, Emmanuel Serrano, Roser Velarde, Francisco Javier Cano-Manuel, Gregorio Mentaberre, Arián Ráez-Bravo, Paulino Fandos, Jorge Ramón López-Olvera
The susceptibility of Iberian ibex (Capra pyrenaica) to Mycoplasma conjunctivae ocular infection and the changes in their interaction over time were studied in terms of clinical outcome, molecular detection and IgG immune response in a captive population that underwent a severe infectious keratoconjunctivitis (IKC) outbreak. Mycoplasma conjunctivae was detected for the first time in the Iberian ibexes coinciding with the IKC outbreak. Its prevalence had a decreasing trend in 2013 that was consistent with the clinical resolution (August 35...
May 19, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28521810/estimation-of-the-burden-of-varicella-in-europe-before-the-introduction-of-universal-childhood-immunization
#9
Margarita Riera-Montes, Kaatje Bollaerts, Ulrich Heininger, Niel Hens, Giovanni Gabutti, Angel Gil, Bayad Nozad, Grazina Mirinaviciute, Elmira Flem, Audrey Souverain, Thomas Verstraeten, Susanne Hartwig
BACKGROUND: Varicella is generally considered a mild disease. Disease burden is not well known and country-level estimation is challenging. As varicella disease is not notifiable, notification criteria and rates vary between countries. In general, existing surveillance systems do not capture cases that do not seek medical care, and most are affected by underreporting and underascertainment. We aimed to estimate the overall varicella disease burden in Europe to provide critical information to support decision-making regarding varicella vaccination...
May 18, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28515093/circulating-soluble-p-selectin-must-dimerize-to-promote-inflammation-and-coagulation-in-mice
#10
Sumith R Panicker, Padmaja Mehta-D'souza, Nan Zhang, Arkadiusz G Klopocki, Bojing Shao, Rodger P McEver
Leukocyte adhesion to P-selectin on activated platelets and endothelial cells induces shedding of the P-selectin ectodomain into the circulation. Plasma soluble P-selectin (sP-selectin) is elevated 3-4-fold in patients with cardiovascular disease. Circulating sP-selectin is thought to trigger signaling in leukocytes that directly contributes to inflammation and thrombosis. However, sP-selectin likely circulates as a monomer, and in vitro studies suggest that sP-selectin must dimerize to induce signaling in leukocytes...
May 17, 2017: Blood
https://www.readbyqxmd.com/read/28511156/the-role-of-the-persistent-enterovirus-infection-in-development-of-acute-stroke
#11
Natalia G Andriushkova, Nataliia S Turchyna, Vadym A Poniatowski, Ludmyla V Dolinchuk, Valentyna V Melnyk, Volodymyr P Shyrobokov, Nataliia V Zakharchenko
INTRODUCTION: The role of enteroviruses in development of dilated cardiomyopathy, myocardial infarction, myocarditis, pericarditis is known. THE AIM: To examine the role of chronic enterovirus infections in development of acute stroke. MATERIAL AND METHODS: Blood samples from 72 patients with acute stroke (study group) and 35 patients without vascular disease (control group) were investigated by reverse transcription polymerase chain reaction for the presence of enterovirus RNA, by using virological method to detect enteroviruses, by ELISA for the levels of IgM and IgG antibodies to enteroviruses...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28507984/immunoprevalence-to-six-waterborne-pathogens-in-beachgoers-at-boquer%C3%A3-n-beach-puerto-rico-application-of-a-microsphere-based-salivary-antibody-multiplex-immunoassay
#12
Swinburne A J Augustine, Kaneatra J Simmons, Tarsha N Eason, Clarissa L Curioso, Shannon M Griffin, Timothy J Wade, Alfred Dufour, G Shay Fout, Ann C Grimm, Kevin H Oshima, Elizabeth A Sams, Mary Jean See, Larry J Wymer
Waterborne infectious diseases are a major public health concern worldwide. Few methods have been established that are capable of measuring human exposure to multiple waterborne pathogens simultaneously using non-invasive samples such as saliva. Most current methods measure exposure to only one pathogen at a time, require large volumes of individual samples collected using invasive procedures, and are very labor intensive. In this article, we applied a multiplex bead-based immunoassay capable of measuring IgG antibody responses to six waterborne pathogens simultaneously in human saliva to estimate immunoprevalence in beachgoers at Boquerón Beach, Puerto Rico...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28506241/socio-demographic-determinants-of-toxoplasma-gondii-seroprevalence-in-migrant-workers-of-peninsular-malaysia
#13
Norhidayu Sahimin, Yvonne A L Lim, Farnaza Ariffin, Jerzy M Behnke, Maria-Gloria Basáñez, Martin Walker, John W Lewis, Rahmah Noordin, Khairul Anuar Abdullah, Siti Nursheena Mohd Zain
BACKGROUND: The number of migrants working in Malaysia has increased sharply since the 1970's and there is concern that infectious diseases endemic in other (e.g. neighbouring) countries may be inadvertently imported. Compulsory medical screening prior to entering the workforce does not include parasitic infections such as toxoplasmosis. Therefore, this study aimed to evaluate the seroprevalence of T. gondii infection among migrant workers in Peninsular Malaysia by means of serosurveys conducted on a voluntary basis among low-skilled and semi-skilled workers from five working sectors, namely, manufacturing, food service, agriculture and plantation, construction and domestic work...
May 15, 2017: Parasites & Vectors
https://www.readbyqxmd.com/read/28503278/conjugate-and-23-valent-pneumococcal-polysaccharide-booster-vaccination-in-asplenic-patients-with-thalassemia-major-a-randomized-clinical-trial-study
#14
Mohammad Sadegh Rezai, Javad Ghaffari, Mohammadreza Mahdavi, Amir Bahari, Shahram Ala
BACKGROUND: Pneumococcal vaccine provides protection against invasive pneumococcal disease in population at risk. This study was conducted to compare the antibody response to 13-valent pneumococcal conjugate vaccine and 23-valent pneumococcal polysaccharide vaccine in patients with thalassemia major. METHODS: A randomized cross-over clinical trial was performed on 50 asplenic patients with thalassemia major who referred to thalassemia center at Bouali Sina Hospital, Sari, Iran from 2013 to 2014...
2017: Caspian Journal of Internal Medicine
https://www.readbyqxmd.com/read/28483414/safety-and-immunogenicity-of-a-parenteral-p2-vp8-p-8-subunit-rotavirus-vaccine-in-toddlers-and-infants-in-south-africa-a-randomised-double-blind-placebo-controlled-trial
#15
Michelle J Groome, Anthonet Koen, Alan Fix, Nicola Page, Lisa Jose, Shabir A Madhi, Monica McNeal, Len Dally, Iksung Cho, Maureen Power, Jorge Flores, Stanley Cryz
BACKGROUND: Efficacy of live oral rotavirus vaccines is reduced in low-income compared with high-income settings. Parenteral non-replicating rotavirus vaccines might offer benefits over oral vaccines. We assessed the safety and immunogenicity of the P2-VP8-P[8] subunit rotavirus vaccine at different doses in South African toddlers and infants. METHODS: This double-blind, randomised, placebo-controlled, dose-escalation trial was done at a single research unit based at a hospital in South Africa in healthy HIV-uninfected toddlers (aged 2 to <3 years) and term infants (aged 6 to <8 weeks, without previous rotavirus vaccination)...
May 5, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/28479902/low-sero-prevalence-of-hepatitis-delta-antibodies-in-hiv-hepatitis-b-co-infected-patients-attending-an-urban-hiv-clinic-in-uganda
#16
Elizabeth Katwesigye, Emmanuel Seremba, Fred Semitala, Ponsiano Ocama
BACKGROUND: Co-infection with hepatitis B (HBV) and hepatitis D (HDV) is common among human immunodeficiency virus (HIV) infected individuals in developing countries and it aggressively accelerates progression of liver disease to cirrhosis and other complications. There is scarcity of data on HDV in sub-Saharan Africa .We investigated the sero-prevalence and factors associated with HDV antibody among HIV/HBV co-infected patients attending a large urban HIV clinic in Uganda. METHODS: We screened 189 HIV/HBV co-infected individuals for anti-HDV immunoglobulin G (IgG) and performed logistic regression to determine the associated factors...
December 2016: African Health Sciences
https://www.readbyqxmd.com/read/28471236/a-study-of-clinical-histopathological-and-direct-immunofluorescence-diagnosis-in-pemphigus-group-utility-of-direct-immunofluorescence
#17
Z Hrabovska, J Jautova, V Hrabovsky
AIMS: To determine the diagnostic accordance between histopathological and direct immunofluorescence diagnosis of patients with autoimmune vesiculobullous skin diseases. BACKGROUND: The term pemphigus refers to a group of autoimmune blistering diseases mediated by auto-antibodies directed against desmoglein proteins. The differentiation between the various bullous diseases is important for treatment and prognosis. Direct immunofluorescence microscopy is still the gold standard in differentiating these diseases...
2017: Bratislavské Lekárske Listy
https://www.readbyqxmd.com/read/28463977/production-of-igg-antibodies-to-pneumococcal-polysaccharides-is-associated-with-expansion-of-icos-circulating-memory-t-follicular-helper-cells-which-is-impaired-by-hiv-infection
#18
Laila N Abudulai, Sonia Fernandez, Karli Corscadden, Sally A Burrows, Michael Hunter, M Christian Tjiam, Lea-Ann S Kirkham, Jeffrey J Post, Martyn A French
Dysfunction of T follicular-helper (TFH) cells is a possible cause of impaired germinal centre (GC) and IgG antibody responses in individuals with human immunodeficiency virus-1 (HIV-1) infection and might contribute to decreased magnitude and isotype diversification of IgG antibodies to pneumococcal polysaccharides (PcPs). We examined the production of IgG1 and IgG2 antibodies to PcPs 4, 6B, 9V and 14 by enumerating antibody secreting cells (ASCs) at day (D) 7 and determining fold-increase in serum antibody levels at D28 after vaccination with unconjugated PcPs in HIV seronegative subjects (n = 20) and in HIV patients who were receiving antiretroviral therapy (ART) (n = 28) or who were ART-naive (n = 11) and determined their association with ICOS+ and ICOS- circulating memory TFH (cmTFH) cells (CD4+CD45RA-CD27+CXCR5+PD-1+) and short lived plasmablasts (SPBs) at D7, and with PcP-specific and total IgM+ and IgG+ memory B cells at D0...
2017: PloS One
https://www.readbyqxmd.com/read/28461573/genetic-and-small-molecule-disruption-of-the-aid-rad51-axis-similarly-protects-nonobese-diabetic-mice-from-type-1-diabetes-through-expansion-of-regulatory-b-lymphocytes
#19
Jeremy J Ratiu, Jeremy J Racine, Muneer G Hasham, Qiming Wang, Jane A Branca, Harold D Chapman, Jing Zhu, Nina Donghia, Vivek Philip, William H Schott, Clive Wasserfall, Mark A Atkinson, Kevin D Mills, Caroline M Leeth, David V Serreze
B lymphocytes play a key role in type 1 diabetes (T1D) development by serving as a subset of APCs preferentially supporting the expansion of autoreactive pathogenic T cells. As a result of their pathogenic importance, B lymphocyte-targeted therapies have received considerable interest as potential T1D interventions. Unfortunately, the B lymphocyte-directed T1D interventions tested to date failed to halt β cell demise. IgG autoantibodies marking humans at future risk for T1D indicate that B lymphocytes producing them have undergone the affinity-maturation processes of class switch recombination and, possibly, somatic hypermutation...
May 1, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28461188/validation-of-antibody-based-strategies-for-diagnosis-of-pediatric-celiac-disease-without-biopsy
#20
Johannes Wolf, David Petroff, Thomas Richter, Marcus Kh Auth, Holm H Uhlig, Martin W Laass, Peter Lauenstein, Andreas Krahl, Norman Händel, Jan de Laffolie, Almuthe C Hauer, Thomas Kehler, Gunter Flemming, Frank Schmidt, Astor Rodriques, Dirk Hasenclever, Thomas Mothes
BACKGROUND AND AIMS: A diagnosis of celiac disease is made based on clinical, genetic, serologic, and duodenal morphology features. Recent pediatric guidelines, based largely on retrospective data, propose omitting biopsy analysis for patients with concentrations of immunoglobulin A against tissue transglutaminase (IgA-TTG) more than 10-fold the upper limit of normal (ULN) and if further criteria are met. A retrospective study concluded that measurements of IgA-TTG and total IgA, or IgA-TTG and IgG against deamidated gliadin (IgG-DGL) could identify patients with and without celiac disease...
April 28, 2017: Gastroenterology
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