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Iron AND febrile seizures

Surbhi Gupta, Anju Aggarwal, M Ma A Faridi, Gargi Rai, Shukla Das, Mrinalini Kotru
OBJECTIVE: To compare levels of IL-6 in children with febrile seizures and febrile controls. METHODS: Study conducted in a tertiary-care hospital in Northern India from November 2013 to April 2015, enrolling 160 children (80 each with febrile seizures and febrile controls), aged6 months - 60 months. Serum IL-6 estimated by ELISA method. Iron study done as per standard technique. All the cases of febrile seizure were followed up at 1 week, 3 months and 6 months for recurrence of seizures...
February 9, 2018: Indian Pediatrics
Byung Ok Kwak, Kyungmin Kim, Soo-Nyung Kim, Ran Lee
PURPOSE: The association between iron deficiency anemia (IDA) and febrile seizures (FS) during childhood is inconclusive due to inconsistent results reported in different studies. We performed a systematic review and meta-analysis to determine an association between IDA and FS in children. METHODS: We searched PubMed, EMBASE, and Cochrane Library databases for studies published up to August 2015 using the following key words: ["iron deficiency" OR "iron status"] AND ["febrile seizure" OR "febrile convulsion"] AND ["pediatric" OR "infant" OR "child"]...
November 2017: Seizure: the Journal of the British Epilepsy Association
Khawaja Tahir Aziz, Naheem Ahmed, Abdul Ghaffar Nagi
BACKGROUND: Febrile fits is common problem in children. Among other risk factors, iron deficiency anaemia is considered as aggravating factor for febrile fits. Iron deficiency anaemia is preventable and treatable disease. The objective of the study was to find out iron deficiency anaemia as risk factor for febrile fits. METHODS: It was a case control study. Thirty cases of febrile fits were recorded. Control group of 30 cases was taken at the same time with same variables but without febrile fits...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
Stéphane Auvin, Lauren Walker, William Gallentine, Sergiusz Jozwiak, Mario Tombini, Graeme J Sills
Among clinical studies, randomized studies as well as well-designed observational studies are providing the highest quality data. In addition, these studies represent a good opportunity to examine biomarkers of ictogenesis and epileptogenesis. To date, no validated molecular or cellular biomarker exists for any aspect of epilepsy. We provide an overview of the inflammatory biomarkers under investigation in prospective clinical studies in epilepsy: proinflammatory cytokines in prolonged febrile seizure; High Mobility Group Box 1 (HMGB1) as a prognosis biomarker in epilepsy and the interaction between inflammation and metabolism, in particular, iron metabolism, in epilepsy...
July 2017: Epilepsia
Ali O Köksal, Osman Özdemir, Bahar Büyükkaragöz, Merve Karaömerlioglu, Ayse D Bulus
INTRODUCTION: We conducted this study to determine the role of iron deficiency (ID) as a risk factor for simple febrile seizure (SFS) in 6- to 60-month-old children. MATERIALS AND METHODS: In this case-control study 100 children aged 6 to 60 months with febrile seizure (FS) (study group) and 100 febrile children without seizures (control group) admitted to Pediatric Departments of Kecioren Training and Research Hospital in between June 2014 and March 2015 were evaluated...
October 2016: Journal of Pediatric Hematology/oncology
Mohammad Reza Sharif, Davood Kheirkhah, Mahla Madani, Hamed Haddad Kashani
INTRODUCTION: Febrile seizure is among the most common convulsion disorders in children, which strikes 2% to 5% of children between 3 to 60 months of age. Some studies have reported that iron deficiency could be a risk factor for febrile seizure. The present study was conducted to compare the rate of iron deficiency anemia in febrile children with and without seizure. MATERIALS AND METHODS: This case-control study evaluated 200 children aged 6-60 month in two 100 person groups (febrile seizure and febrile without convulsion) in Kashan...
June 25, 2015: Global Journal of Health Science
Valia Papageorgiou, Euthymia Vargiami, Eleutherios Kontopoulos, Panagiotis Kardaras, Marina Economou, Miranta Athanassiou-Mataxa, Fenella Kirkham, Dimitrios I Zafeiriou
OBJECTIVE: The relationship between iron status and febrile seizures has been examined in various settings, mainly in the Developing World, with conflicting results. The aim of this study was to investigate any association between iron deficiency and febrile seizures (FS) in European children aged 6-60 months. DESIGN: Prospective, case-control study. SETTING: Greek population in Thessaloniki. PATIENTS: 50 patients with febrile seizures (cases) and 50 controls (children presenting with fever, without seizures)...
September 2015: European Journal of Paediatric Neurology: EJPN
David King, Andrew King
No abstract text is available yet for this article.
October 2014: Archives of Disease in Childhood
Razieh Fallah, Behnaz Tirandazi, Farzad Ferdosian, Nafiseh Fadavi
OBJECTIVE: Seizures are the most common pediatric neurologic problem. Research of the association between iron deficiency and seizures has shown conflicting results. This study evaluates iron status of children with a first seizure attack (febrile seizure (FS) or first unprovoked afebrile seizure (FUS) and healthy control group. MATERIALS & METHODS: In a cross sectional case control study, iron status of 6-60 month year old admitted children with first seizure to Shahid Sadoughi Hospital from August 2011-December 2012 were evaluated and compared with healthy control children that were referred to primary health care center of Azadshar, Yazd, Iran...
2014: Iranian Journal of Child Neurology
Fateme Ghasemi, Fateme Valizadeh, Nadere Taee
OBJECTIVE: Considering the recurrence of febrile seizure and costs for families, many studies have attempted to identify its risk factors. Some recent studies have reported that anemia is more common in children with febrile convulsion, whereas others have reported that iron deficiency raises the seizure threshold. This study was done to compare iron-deficiency anemia in children with first FS with children having febrile illness alone and with healthy children. MATERIALS & METHODS: This case-control study evaluated 300 children in three groups (first FS, febrile without convulsion, and healthy) in Khoramabad Madani Hospital from September 2009 to September 2010...
2014: Iranian Journal of Child Neurology
Nadia Waheed, Muhammad Asghar Butt
BACKGROUND: Febrile seizure a common convulsion disorder in children, can lead to increased morbidity and mortality because of risk of aspiration and hypoxia during prolonged febrile seizures. There are many risk factors associated with febrile seizures and their recurrence. We conducted this study to see if there is a role of iron status in febrile seizures. METHODS: This cross-sectional study was conducted in 323 children 6 months to 5 years of age admitted in department of Paediatric DHQ Hospital Faisalabad with fever and seizures from July 2009 to April 2011...
July 2012: Journal of Ayub Medical College, Abbottabad: JAMC
Mansour Sadeghzadeh, Parisa Khoshnevis Asl, Esrafil Mahboubi
OBJECTIVE: Febrile seizure is one of the most common neurological conditions of childhood. Several theories, such as iron deficiency anemia have been proposed as the pathogenesis of this condition. The aim of this study was to find the association between iron deficiency anemia and febrile seizures in children aged 6 months to 3 years admitted in Valie Asr hospital in Zanjan. MATERIALS &METHODS: Hemoglobin (Hb), mean corpuscular volume (MCV), serum iron (SI), total iron binding capacity (TIBC) and SI/TIBC ratio were assessed in one hundred children with febrile seizures and compared to the values of one hundred healthy children presenting in a heath care center in the same period as the control group...
2012: Iranian Journal of Child Neurology
R Fallah, B Tirandazi, S Akhavan Karbasi, M Golestan
BACKGROUND: Febrile seizure (FS) is the most common childhood seizures which occur in 2-5% of children. Studies about association between iron deficiency and febrile seizure have shown contradictory results. The purpose of this study was to compare the iron status of children with first febrile seizure and healthy control group. MATERIALS AND METHODS: In an analytic case-control study , iron status of 6 to 60 months old admitted children with first FS to Shahid Sadoughi Hospital from December 2011 to August 2012 was evaluated and compared with healthy age and sex matched control children whom were referred for routine health care to primary health care center of Azadshar Yazd, Iran...
2013: Iranian Journal of Pediatric Hematology and Oncology
Sepideh Amouian, Sakineh Mohammadian, Naser Behnampour, Mohsen Tizrou
BACKGROUND AND AIM: Pathogenesis of Febrile Convulsion (FC) is unknown but some elements and genetic predispositions have been considered in the top list. This case-control study was designed to compare some trace elements in paediatrics who were admitted with FC and those in febrile ones without seizure attacks at an academic hospital in northeast of Iran. MATERIAL AND METHODS: This case-control study was done from June 2010 to July 2011 on 160 paediatrics (6-months to 5-years old) who were diagnosed with FC and on 160 age-matched febrile children as control group...
October 2013: Journal of Clinical and Diagnostic Research: JCDR
M A Choudhury, M Zaman, A H Mollah, M A Hoque, L E Fatmi, M N Islam, K J Bhuiyan, M A Hossain
This hospital based cross sectional analytic study was carried out in department of Pediatrics Dhaka Medical College Hospital and Combined Military Hospital from July 2009 to June 2010 to find out the relationship of iron status with febrile seizure in children. Sixty children aged 6 months to 5 years having febrile seizure were enrolled as cases after taking proper consent by purposive sampling. Sixty age matched children with fever but no seizures were taken as control after taking proper consent. Children having a febrile seizure, developmental delay, hemorrhagic disorder, severe malnutrition or micronutrient deficiency and abnormal CSF findings were excluded from the study...
April 2013: Mymensingh Medical Journal: MMJ
Daniel H Wiseman, Alison May, Stephen Jolles, Philip Connor, Colin Powell, Matthew M Heeney, Patricia J Giardina, Robert J Klaassen, Pranesh Chakraborty, Michael T Geraghty, Nathalie Major-Cook, Caroline Kannengiesser, Isabelle Thuret, Alexis A Thompson, Laura Marques, Stephen Hughes, Denise K Bonney, Sylvia S Bottomley, Mark D Fleming, Robert F Wynn
Congenital sideroblastic anemias (CSAs) are a heterogeneous group of inherited disorders identified by pathological erythroid precursors with perinuclear mitochondrial iron deposition in bone marrow. An international collaborative group of physicians and laboratory scientists collated clinical information on cases of CSA lacking known causative mutations, identifying a clinical subgroup of CSA associated with B immunodeficiency, periodic fevers, and development delay. Twelve cases from 10 families were identified...
July 4, 2013: Blood
Hojjat Derakhshanfar, Ali Abaskhanian, Hosein Alimohammadi, Mona ModanlooKordi
AIM: Febrile convulsion (FC) is a common cause of seizure in young children, with an excellent prognosis. In addition to genetic predisposition, FCs are generally thought to be induced by elemental changes such as iron deficiency. Regarding the high prevalence of febrile seizure and iron deficiency anemia in children, the aim was to investigate the role of iron deficiency anemia in FC patients. METHODS: This case-control study was performed in 500 children with febrile seizures (case) and 500 febrile children without seizures (control), referred to Mofid hospital in Tehran during one year (Nov 2009-Nov 2010)...
August 2012: Medicinski Glasnik
Soheila Zareifar, Hamid Reza Hosseinzadeh, Nader Cohan
OBJECTIVES: The aim of this study was to determine the association between iron status and febrile seizures in children aged 6 months to 5 years. METHODS: This prospective case-control study enrolled 300 children who presented with febrile seizures (case group) and 200 children who presented with a febrile illness without seizures (control group) from March 2007 to January 2009. Hemoglobin, mean corpuscular volume and serum ferritin concentration were compared in the two groups in relation to age, sex and use of iron supplementation...
October 2012: Seizure: the Journal of the British Epilepsy Association
S Akbayram, M Cemek, A Büyükben, F Aymelek, S Karaman, F Yilmaz, M Dogan, H Caksen
Febrile seizures (FS) are the most common cause of seizures in children. The exact etiopathogenesis is unknown but involves factors like genetic predisposition and alterations in the levels of neurotransmitters and some trace elements. The study includes 48 consecutive children with FS, and 55 healthy age matched control subjects. Calcium, magnesium and potassium concentrations in the febrile study group were lower than in the control group (p<0.05). Iron and Gallium levels in the study group were lower than in the control group (p<0...
2012: Bratislavské Lekárske Listy
Farhad Heydarian, Hosein Vatankhah
OBJECTIVE: To assess the relationship between anemia and first simple febrile convulsion in patients 6 months to 5 years old. METHODS: This cross-sectional study was performed on 240 patients aged 6 months to 5 years old from 10 October 2010 to 15 December 2011 at Ghaem Hospital, Imam Reza Hospital, and Dr. Sheikh Hospital, Mashhad, Iran. Patients were divided into 2 groups: the control group who had fever without seizure, and the case group who had first simple febrile seizure...
July 2012: Neurosciences: the Official Journal of the Pan Arab Union of Neurological Sciences
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