Jun Liao, Lidong Gong, Qingqiang Xu, Jingya Wang, Yuanyuan Yang, Shiming Zhang, Junwei Dong, Kerui Lin, Zichao Liang, Yuhan Sun, Yongxu Mu, Zhengju Chen, Ying Lu, Qiang Zhang, Zhiqiang Lin
Brain disorders represent a significant challenge in medical science due to the formidable blood-brain barrier (BBB), which severely limits the penetration of conventional therapeutics, hindering effective treatment strategies. This review delves into the innovative realm of biomimetic nanodelivery systems, including stem cell-derived nanoghosts, tumor cell membrane-coated nanoparticles, and erythrocyte membrane-based carriers, highlighting their potential to circumvent the BBB's restrictions. By mimicking native cell properties, these nanocarriers emerge as a promising solution for enhancing drug delivery to the brain, offering a strategic advantage in overcoming the barrier's selective permeability...
April 7, 2024: Advanced Materials