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Medication adverse events

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https://www.readbyqxmd.com/read/29917325/introduction-of-the-colorectal-cancer-screening-program-results-from-a-single-centre-study
#1
Nina C A Vermeer, Renu R Bahadoer, Esther Bastiaannet, Fabian A Holman, Elma Meershoek-Klein Kranenbarg, Gerrit-Jan Liefers, Cornelis J H van de Velde, Koen C M J Peeters
AIM: In 2014, a national colorectal cancer (CRC) screening program was launched in the Netherlands. It is difficult to assess for the individual CRC patient whether the oncological benefits of surgery will outweigh the morbidity of the procedure, especially in early lesions. This study compares patient and tumour characteristics between screen-detected and non-screen-detected patients. Secondly, we present an overview of treatment options and clinical dilemmas when treating patients with early stage colorectal disease...
June 19, 2018: Colorectal Disease: the Official Journal of the Association of Coloproctology of Great Britain and Ireland
https://www.readbyqxmd.com/read/29917143/implementation-of-medication-related-indicators-of-potentially-preventable-hospitalizations-in-a-national-chronic-disease-management-program-for-older-patients-with-multimorbidity
#2
Gillian E Caughey, Jodie B Hillen, Stephanie Bacon, Nicholas Bullock, Virginia Bullock, Lisa Kalisch Ellett
Initial assessment: Older people are at increased risk of medication-related potentially preventable hospitalizations (MR-PPH) due to the presence of multiple chronic conditions (multimorbidity) and subsequent polypharmacy. Choice of solution: A pilot study was conducted, using evidence-based indicators to detect older patients in a chronic disease management program (CDMP) at risk of hospitalization due to sub-optimal medication use. Implementation: Previously validated indicators for MR-PPH were applied to patients with multimorbidity, aged 65 years or older and who were enrolled in a national community-based CDMP...
June 18, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29916586/-personalized-medicine-and-medical-malpractice
#3
Santo Davide Ferrara, Guido Viel
OBJECTIVES: The manuscript deals with personalized medicine and medical liability in Europe and Italy, addressing the importance of synergistic collaboration between clinical and medico-legal professionals in order to appropriately investigate medical errors and prevent any future adverse event. METHODS: Following a rapid epidemiological overview of mala praxis in Europe, the manuscript presents and discusses the International Guidelines developed and adopted by the International Academy of Legal Medicine (IALM), which guide the work of the medical experts under both criminal and/or civil law...
November 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29916582/-allergens-in-occupational-allergy-risk-management
#4
Mario Di Gioacchino, Luca Di Giampaolo, Alessia Gatta, Annalisa Flacco, Rocco Mangifesta, Qiao Niu, Claudia Petrarca
OBJECTIVES: The first essential aspect for the prevention of occupational allergy is related to the accurate allergen identification and characterization. At present many efforts are made to characterize the potential for a chemical to be a sensitizing agent. METHODS: 'Omics' show great promise to identify key cellular and molecular events relevant to development of an adverse outcome pathway for respiratory sensitizers. One approach that shows promise is based on the measurement of the peptide reactivity of chemicals; the potential to form stable associations with protein/peptide being a key requirement for the induction of sensitization...
November 2017: Giornale Italiano di Medicina del Lavoro Ed Ergonomia
https://www.readbyqxmd.com/read/29915666/evaluation-of-amnion-derived-mesenchymal-stem-cells-for-treatment-resistant-moderate-crohn-s-disease-study-protocol-for-a-phase-i-ii-dual-centre-open-label-uncontrolled-dose-response-trial
#5
Shinsuke Otagiri, Shunsuke Ohnishi, Arisa Miura, Hiroshi Hayashi, Izumi Kumagai, Yoichi M Ito, Takehiko Katsurada, Shiro Nakamura, Rika Okamoto, Kenichi Yamahara, Kyu Yong Cho, Toshiyuki Isoe, Norihiro Sato, Naoya Sakamoto
Introduction: The medical treatment options for patients with Crohn's disease (CD) are limited and patients resistant to those therapies are left requiring surgical operations that usually only achieve some symptomatic relief. Mesenchymal stem cells (MSC) have been shown to be effective for the treatment of CD, and we have demonstrated in animal experiments that human amnion-derived MSCs (AMSC) are a potential new therapeutic strategy. Therefore, we designed this study to investigate the safety and efficacy of AMSCs in patients with treatment-resistant CD...
2018: BMJ Open Gastroenterology
https://www.readbyqxmd.com/read/29915211/prognostic-value-of-culprit-artery-double-stranded-dna-in-st-segment-elevated-myocardial-infarction
#6
Xiqiang Wang, Dandan Yang, Jing Liu, Xiude Fan, Aiqun Ma, Ping Liu
The double-stranded DNA (dsDNA) which is scaffold of neutrophil extracellular traps (NETs) has been reported to be associated with the occurrence of major adverse cardiovascular events (MACEs) in patients with coronary atherosclerosis. However, the relationship between the dsDNA and the occurrence of MACEs in patients with ST-segment elevated myocardial infarction (STEMI) remains unclear. In this study, 142 consecutive STEMI patients were admitted to medical institutions. Blood from the infarct-related coronary artery (ICA) and peripheral artery (PA) were obtained during percutaneous coronary intervention...
June 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29914924/intravenous-cefazolin-plus-oral-probenecid-versus-oral-cephalexin-for-the-treatment-of-skin-and-soft-tissue-infections-a-double-blind-non-inferiority-randomised-controlled-trial
#7
Dawn Dalen, Amy Fry, Samuel G Campbell, Jeffrey Eppler, Peter J Zed
OBJECTIVE: The purpose of our study was to determine if cephalexin 500 mg orally four times daily was non-inferior to cefazolin 2 g intravenously daily plus probenecid 1 g orally daily in the management of patients with uncomplicated mild-moderate skin and soft tissue infection (SSTI) presenting to the ED. METHODS: This was a prospective, multicentre, double dummy-blind, randomised controlled non-inferiority trial conducted at two tertiary care teaching hospitals in Canada...
June 18, 2018: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29913894/evaluation-of-a-novel-chemokine-receptor-2-ccr2-antagonist-in-painful-diabetic-polyneuropathy
#8
Jarkko Kalliomäki, Bror Jonzon, Karin Huizar, Michael O'Malley, Anita Andersson, David M Simpson
Background and aims Preclinical data suggest that the chemokine receptor 2 (CCR2) is involved in the pathophysiology of neuropathic pain through modulation of neuronal excitability, synaptic transmission and activation of spinal cord microglia. CCR2-antagonists have shown to be effective in preclinical models of neuropathic pain. The aim of this study was to evaluate the analgesic efficacy, safety and tolerability of a novel CCR2-antagonist, AZD2423, in patients with painful diabetic neuropathy (PDN). Methods This was a double-blind, randomized, parallel-group, multi-center study in patients with symmetric distal sensory polyneuropathy due to type 1 or 2 diabetes and duration of neuropathic pain between 3 months and 5 years...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913883/evaluation-of-the-analgesic-efficacy-of-azd1940-a-novel-cannabinoid-agonist-on-post-operative-pain-after-lower-third-molar-surgical-removal
#9
Jarkko Kalliomäki, Märta Segerdahl, Lynn Webster, Annika Reimfelt, Karin Huizar, Peter Annas, Rolf Karlsten, Hans Quiding
Aim To evaluate the analgesic efficacy of AZD1940, a novel peripherally acting cannabinoid CB1/CB2 receptor agonist, in patients undergoing third molar surgical removal. Methods This was a randomized, double-blind, placebo-controlled study in patients scheduled for surgical removal of an impacted lower third molar. Patients received a single oral dose of 800 μg AZD1940, 500 mg naproxen or placebo 1.5 h before surgery. The dose of 800 μg AZD1940 was selected based on earlier data from a single dose study in man, in which it was identified as the highest well tolerated dose...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29913632/promising-effects-of-donepezil-when-added-to-patients-treated-with-gabapentin-for-neuropathic-pain
#10
A Basnet, S Butler, P Hartvig Honoré, M Butler, T E Gordh, K Kristensen, O J Bjerrum
Aims The clinical relevance of adding the acetylcholinesterase inhibitor donepezil to existing gabapentin treatment in patients with post-traumatic neuropathic pain was explored in this open-label study. The two drugs have previously shown synergism following co-administration in nerve-injured rats [1,2]. Methods The study comprised two consecutive periods of minimum six weeks: (1) titration of gabapentin until highest tolerable dose or maximum 24GG mg daily; and (2) addition of donepezil 5 mg once daily to the fixed gabapentin dose...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29912733/a-paradigm-shift-toward-terminally-sterilized-devices
#11
Aakash Agarwal, Adam MacMillan, Vijay Goel, Anand K Agarwal, Chris Karas
Given the complexity of the sterilization process, and the risk involved in absence of strict adherence to the protocol described by the medical device manufacturers, terminally sterilized devices are emerging and being promoted in the field of medical practices. The characteristics associated with conventional reprocessing are demanding logistics, costs of delay, operations and adverse events, and unacceptable liability. Demanding logistics were a result of decoupled staff between the operating room and sterilize processing department, understaffed and high-volume processing with an additional burden due to inventory management and inefficient training...
June 15, 2018: Clinical Spine Surgery
https://www.readbyqxmd.com/read/29912668/student-response-to-reports-of-unprofessional-behavior-assessing-risk-of-subsequent-professional-problems-in-medical-school
#12
Michael A Ainsworth, Karen M Szauter
BACKGROUND: An early concern note (ECN) program is used by some medical schools to identify, counsel, and intervene when students exhibit unprofessional behavior. Student maturity, insight, propensity for reflection, and receptiveness to feedback have been suggested as predictors of future behavior. OBJECTIVE: We hypothesized that (a) classifying students with a first ECN based on their response to the report would identify students at risk of repeat ECNs better than the action that prompted it and (b) receipt of multiple ECNs would identify students at risk of adverse academic events...
December 2018: Medical Education Online
https://www.readbyqxmd.com/read/29912469/effects-of-patient-safety-auditing-in-hospital-care-results-of-a-mixed-method-evaluation-part-1
#13
Mirelle Hanskamp-Sebregts, Marieke Zegers, Gert P Westert, Wilma Boeijen, Steven Teerenstra, Petra J van Gurp, Hub Wollersheim
Objective: To evaluate the effectiveness of internal auditing in hospital care focussed on improving patient safety. Design, Setting and Participants: A before-and-after mixed-method evaluation study was carried out in eight departments of a university medical center in the Netherlands. Intervention(s): Internal auditing and feedback focussed on improving patient safety. Main Outcome Measure(s): The effect of internal auditing was assessed 15 months after the audit, using linear mixed models, on the patient, professional, team and departmental levels...
June 15, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29912467/trans-disciplinary-advanced-allied-health-practitioners-for-acute-hospital-inpatients-a-feasibility-study
#14
Dina Watterson, Kerrie Walter, Lisa O'Brien, Desiree Terrill, Kathleen Philip, Indi Swan, Lisa Somerville
Objective: To explore cost-efficiency, safety and acceptability of trans-disciplinary advanced allied health (AH) practitioners for acute adult general medicine inpatients. Design: Quasi-experimental feasibility study. Setting: Three acute general medical units in an Australian urban hospital. Participants: Two hundred and fifty-six acute hospital inpatients. Main Outcome Measures: Cost-efficiency measures included AH service utilization and length of stay (LOS)...
June 15, 2018: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/29912272/evaluating-statistical-approaches-to-leverage-large-clinical-datasets-for-uncovering-therapeutic-and-adverse-medication-effects
#15
Leena Choi, Robert J Carroll, Cole Beck, Jonathan D Mosley, Dan M Roden, Joshua C Denny, Sara L Van Driest
Motivation: Phenome-wide association studies (PheWAS) have been used to discover many genotype-phenotype relationships and have the potential to identify therapeutic and adverse drug outcomes using longitudinal data within electronic health records (EHRs). However, the statistical methods for PheWAS applied to longitudinal EHR medication data have not been established. Results: In this study, we developed methods to address two challenges faced with reuse of EHR for this purpose: confounding by indication, and low exposure and event rates...
April 18, 2018: Bioinformatics
https://www.readbyqxmd.com/read/29912044/cardiac-immune-related-adverse-events-in-immune-checkpoint-inhibition-therapy
#16
Aaron D Brumbaugh, Roshni Narurkar, Kaushal Parikh, Michael Fanucchi, William H Frishman
Immune checkpoint inhibitors present clinicians with both an exciting step forward in cancer treatment and the unknown possibilities of an unshackled immune system. The latter phenomena, known as immune-related adverse events (irAEs), are of particular interest because they may affect any organ system with autoimmune-like pathologies, such as hepatitis and colitis. Within the cardiovascular system, irAEs associated with immune checkpoint blockade exist as a broad clinical spectrum, with autoimmune myocarditis being the best-characterized entity at this time...
June 14, 2018: Cardiology in Review
https://www.readbyqxmd.com/read/29911601/oral-oxycodone-for-pain-after-caesarean-section-a-randomized-comparison-with-nurse-administered-iv-morphine-in-a-pragmatic-study
#17
Boel Niklasson, Catarina Arnelo, Susanne Georgsson Öhman, Märta Segerdahl, Agneta Blanck
Background and aims The present randomized open label parallel group study was conducted to evaluate if an oral oxycodone (OXY) regimen can be at least equally effective and as safe for postoperative analgesia after caesarean section (CS) as a standard of care program using nurse-administered intravenous morphine (IVM), followed by oral codeine. Methods Eighty women (40 + 40) were scheduled for elective CS under spinal anaesthesia. All patients received postoperative multimodal analgesic therapy, including ibuprofen and paracetamol...
December 29, 2017: Scandinavian Journal of Pain
https://www.readbyqxmd.com/read/29911480/safety-and-feasibility-of-intravascular-lithotripsy-for-treatment-of-below-the-knee-arterial-stenoses
#18
Marianne Brodmann, Andrew Holden, Thomas Zeller
PURPOSE: To evaluate the safety and feasibility of treating calcified infrapopliteal stenoses using an intravascular lithotripsy (IVL) system. METHODS: The Disrupt BTK study was a prospective, nonrandomized, multicenter, feasibility, and safety trial that enrolled 20 patients (mean age 79.0±9.6 years; 14 men) at 3 participating sites ( ClinicalTrials.gov identifier NCT02911623). Fifteen patients had Rutherford category 5 ischemia, and all patients had moderate to severe below-the-knee arterial calcification...
June 1, 2018: Journal of Endovascular Therapy
https://www.readbyqxmd.com/read/29911393/renal-and-cardiac-implications-of-sodium-glucose-cotransporter-2-sglt2-inhibitors-the-state-of-the-science
#19
Joseph E Cruz, Tania Ahuja, Mary Barna Bridgeman
OBJECTIVE: To review the role of the sodium-glucose cotransporter-2 (SGLT2) inhibitors in the management of type 2 diabetes (T2DM), including the effects on renal and cardiovascular (CV) outcomes. DATA SOURCES: A literature search of MEDLINE databases (1964 through May 2018) was conducted utilizing key words sodium-glucose co-transporter-2 inhibitors, SGLT2 inhibitors, and diabetes; additional limits for drug names were added. STUDY SELECTION AND DATA EXTRACTION: Available English-language data from reviews, abstracts, presentations, and clinical trials of use of SGLT2 therapy specifically detailing outcomes on CV and renal disease in humans were reviewed...
June 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29909790/effect-of-discontinuation-v-maintenance-of-antipsychotic-medication-on-relapse-rates-in-patients-with-remitted-stable-first-episode-psychosis-a-meta-analysis
#20
Taro Kishi, Toshikazu Ikuta, Yuki Matsui, Ken Inada, Yuki Matsuda, Kazuo Mishima, Nakao Iwata
BACKGROUND: Discontinuation of antipsychotics predisposes patients with remitted/stable first-episode psychosis (FEP) to a higher risk of relapse, but it remains unclear how long discontinuation increases the relapse rate in these patients compared with maintenance. METHODS: This meta-analysis of randomized controlled trials (RCTs) compared relapse rates in FEP patients between antipsychotic treatment discontinuation and maintenance groups at 1, 2, 3, 6, 9, 12 (primary), and 18-24 months...
June 18, 2018: Psychological Medicine
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