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https://www.readbyqxmd.com/read/29791567/immunohistological-study-of-the-effect-of-vascular-endothelial-growth-factor-on-the-angiogenesis-of-mature-root-canals-in-rat-molars
#1
Cleber Keiti Nabeshima, José Edgar Valdivia, Hector Caballero-Flores, Victor Elias Arana-Chavez, Manoel Eduardo de Lima Machado
Tissue bioengineering has been applied to Endodontics to seek a more biological treatment. The presence of blood vessels is crucial for cell nutrition during tissue formation. Objective This study analysed the application of vascular endothelial growth factor (VEGF) in the angiogenesis of mature root canals. Material and methods Upper first molars of twelve 13-week old Wistar male rats were used. The root pulp of the mesiobuccal canal was removed and the root canal instrumented with K-files up to size #25. Periapical bleeding was induced into the root canal by introducing a #15 K-file beyond the apex...
2018: Journal of Applied Oral Science: Revista FOB
https://www.readbyqxmd.com/read/29777616/regenerative-endodontics-a-review
#2
REVIEW
S G Kim, M Malek, A Sigurdsson, L M Lin, B Kahler
The European Society of Endodontology and the American Association for Endodontists have released position statements and clinical considerations for regenerative endodontics. There is increasing literature on this field since the initial reports of Iwaya et al. (2001) and Banchs & Trope (2004). Endogenous stem cells from an induced periapical bleeding and scaffolds using blood clot, platelet rich plasma or platelet rich fibrin have been utilized in regenerative endodontics. This approach has been described as a 'paradigm shift" and considered the first treatment option for immature teeth with pulp necrosis...
May 19, 2018: International Endodontic Journal
https://www.readbyqxmd.com/read/29770705/gingival-mesenchymal-stem-cells-outperform-haploidentical-dental-pulp-derived-mesenchymal-stem-cells-in-proliferation-rate-migration-ability-and-angiogenic-potential
#3
Ioannis Angelopoulos, Claudia Brizuela, Maroun Khoury
High donor variation makes comparison studies between different dental sources dubious. Dental tissues offer a rare opportunity for comparing the biological characteristics of haploidentical mesenchymal stem cells (MSCs) isolated from the same donor. The objective was to identify the optimal dental source of MSCs through a biological and functional comparison of haploidentical MSCs from gingival (GMSCs) and dental pulp stem cells (DPSCs) focusing mainly on their angiogenic potential. The comparison study included (1) surface markers expression, (2) mesodermal differentiation capacity (chondrogenic, adipogenic, and osteogenic), (3) proliferation, (4) migration potential, (5) ability to form colony units, and (6) angiogenic potential in vitro and in vivo...
January 1, 2018: Cell Transplantation
https://www.readbyqxmd.com/read/29770323/dental-mesenchymal-stem-cell-based-translational-regenerative-dentistry-from-artificial-to-biological-replacement
#4
REVIEW
Mona K Marei, Rania M El Backly
Dentistry is a continuously changing field that has witnessed much advancement in the past century. Prosthodontics is that branch of dentistry that deals with replacing missing teeth using either fixed or removable appliances in an attempt to simulate natural tooth function. Although such "replacement therapies" appear to be easy and economic they fall short of ever coming close to their natural counterparts. Complications that arise often lead to failures and frequent repairs of such devices which seldom allow true physiological function of dental and oral-maxillofacial tissues...
2018: Frontiers in Bioengineering and Biotechnology
https://www.readbyqxmd.com/read/29765407/effects-of-transplanted-heparin-poloxamer-hydrogel-combining-dental-pulp-stem-cells-and-bfgf-on-spinal-cord-injury-repair
#5
Lihua Luo, Abdullkhaleg Ali Albashari, Xiaoyan Wang, Ling Jin, Yanni Zhang, Lina Zheng, Jianjian Xia, Helin Xu, Yingzheng Zhao, Jian Xiao, Yan He, Qingsong Ye
Spinal cord injury (SCI) is one of serious traumatic diseases of the central nervous system and has no effective treatment because of its complicated pathophysiology. Tissue engineering strategy which contains scaffolds, cells, and growth factors can provide a promising treatment for SCI. Hydrogel that has 3D network structure and biomimetic microenvironment can support cellular growth and embed biological macromolecules for sustaining release. Dental pulp stem cells (DPSCs), derived from cranial neural crest, possess mesenchymal stem cell (MSC) characteristics and have an ability to provide neuroprotective and neurotrophic properties for SCI treatment...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29758290/proteome-response-of-dental-pulp-cells-to-exogenous-fgf8
#6
Rozaliya Tsikandelova, Petko Mladenov, Sébastien Planchon, Silvia Kalenderova, Maria Dragneva, Zornitsa Mihaylova, Pavel Stanimirov, Vanyo Mitev, Jenny Renaut, Nikolay Ishkitiev
FGF8 specifies early tooth development by directing the migration of the early tooth founder cells to the site of tooth emergence. To date the effect of the FGF8 in adult dental pulp has not been studied. We have assessed the regenerative potential of FGF8 by evaluating changes in the proteome landscape of dental pulp following short- and long-term exposure to recombinant FGF8 protein. In addition, we carried out qRT PCR analysis to determine extracellular/adhesion gene marker expression and assessed cell proliferation and mineralization in response to FGF8 treatment...
May 11, 2018: Journal of Proteomics
https://www.readbyqxmd.com/read/29729540/deep-eutectic-solvent-pretreatment-enabling-full-utilization-of-switchgrass
#7
Zhu Chen, Wesley D Reznicek, Caixia Wan
In this study, an acidified, aqueous DES comprising choline chloride: glycerol (ChCl:Gly) was used to fractionate switchgrass into three major streams under a relatively mild condition: cellulose-rich pulp, lignin, and xylose-rich liquor. The pulp showed good digestibility with about 89% glucose yield. The solvent can be recycled successfully and reused for at least four more pretreatment cycles while maintaining its pretreatment capability. The solvent recycling also improved the lignin recovery from the pretreatment liquor...
April 18, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29703618/biological-analysis-of-simvastatin-releasing-chitosan-scaffold-as-a-cell-free-system-for-pulp-dentin-regeneration
#8
Diana G Soares, Giovanna Anovazzi, Ester Alves F Bordini, Uxua O Zuta, Maria Luísa A Silva Leite, Fernanda G Basso, Josimeri Hebling, Carlos A de Souza Costa
INTRODUCTION: The improvement of biomaterials capable of driving the regeneration of the pulp-dentin complex mediated by resident cells is the goal of regenerative dentistry. In the present investigation, a chitosan scaffold (CHSC) that released bioactive concentrations of simvastatin (SIM) was tested, aimed at the development of a cell-free tissue engineering system. METHODS: First, we performed a dose-response assay to select the bioactive dose of SIM capable of inducing an odontoblastic phenotype in dental pulp cells (DPCs); after which we evaluated the synergistic effect of this dosage with the CHSC/DPC construct...
April 24, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29680723/mineral-trioxide-aggregate-with-mussel-inspired-surface-nanolayers-for-stimulating-odontogenic-differentiation-of-dental-pulp-cells
#9
Ming-Gene Tu, Chia-Che Ho, Tuan-Ti Hsu, Tsui-Hsien Huang, Min-Jhen Lin, Ming-You Shie
INTRODUCTION: This research was intended to evaluate the feasibility of mineral trioxide aggregate (MTA) powder coated with polydopamine (PDA) in dental and bone tissue regeneration by investigating the hydration, physicochemical properties, and biological performance of hydrated cements. METHODS: The MTA powder was well suspended in a dopamine solution buffered at a pH of 8.5 using tris(hydroxymethyl)aminomethane buffer and vigorously stirred for 12 hours at room temperature...
April 18, 2018: Journal of Endodontics
https://www.readbyqxmd.com/read/29679633/influence-of-naringenin-on-the-biofilm-formation-of-streptococcus-mutans
#10
Jiaxi Yue, Hongye Yang, Siying Liu, Fangfang Song, Jingmei Guo, Cui Huang
OBJECTIVES: To evaluate the effect of naringenin on the biofilm formation of Streptococcus mutans (S. mutans), and to investigate its mechanisms of action and biological toxicity. METHODS: Minimum inhibitory concentrations, growth curves, and biofilm inhibition rates of naringenin were determined to assess its antimicrobial effect on S. mutans. The morphology of S. mutans and the structure of biofilm were observed by FESEM and CLSM. Bacterial aggregation, bacterial surface hydrophobicity, and real-time PCR for gtfB, gtfC, comD, comE, and luxS mRNA expression were assessed to preliminarily investigate the mechanisms of action...
April 18, 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29666112/increased-erythrophagocytosis-induces-ferroptosis-in-red-pulp-macrophages-in-a-mouse-model-of-transfusion
#11
Lyla A Youssef, Abdelhadi Rebbaa, Sergey Pampou, Stuart P Weisberg, Brent R Stockwell, Eldad A Hod, Steven L Spitalnik
Macrophages play important roles in recycling iron derived from the clearance of red blood cells (RBCs). They are also a critically important component of host defense, protecting against invading pathogens. However, the effects on macrophage biology of acutely ingesting large numbers of RBCs are not completely understood. To investigate this issue, we used a mouse model of RBC transfusion and clearance, which mimics the clinical setting. In this model, transfusions of refrigerator storage-damaged (i.e., "old") RBCs led to increased erythrophagocytosis by splenic red pulp macrophages (RPMs)...
April 17, 2018: Blood
https://www.readbyqxmd.com/read/29655760/psidium-cattleianum-fruits-a-review-on-its-composition-and-bioactivity
#12
REVIEW
Elisa Dos Santos Pereira, Juliana Vinholes, Rodrigo C Franzon, Gabriel Dalmazo, Márcia Vizzotto, Leonardo Nora
Psidium cattleianum Sabine, commonly known as araçá, is a Brazilian native fruit, which is very juicy, with sweet to sub acid pulp and a spicy touch. The fruit can be eaten fresh or processed into juice, jellies and ice creams. Araçás are source of vitamin C, minerals, fatty acids, polysaccharides, volatile compounds, carotenoids and phenolic compounds, which can provide nutrients and phytochemical agents with different biological functions. Different pharmacological studies demonstrate that P. cattleianum exerts antioxidant, antidiabetic, anticarcinogenic, antimicrobial, anti-inflammatory and antiaging effects...
August 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29650947/hsa-let-7c-controls-the-committed-differentiation-of-igf-1-treated-mesenchymal-stem-cells-derived-from-dental-pulps-by-targeting-igf-1r-via-the-mapk-pathways
#13
Gen-Xia Liu, Shu Ma, Yao Li, Yan Yu, Yi-Xiang Zhou, Ya-Die Lu, Lin Jin, Zi-Lu Wang, Jin-Hua Yu
The putative tumor suppressor microRNA let-7c is extensively associated with the biological properties of cancer cells. However, the potential involvement of let-7c in the differentiation of mesenchymal stem cells has not been fully explored. In this study, we investigated the influence of hsa-let-7c (let-7c) on the proliferation and differentiation of human dental pulp-derived mesenchymal stem cells (DPMSCs) treated with insulin-like growth factor 1 (IGF-1) via flow cytometry, CCK-8 assays, alizarin red staining, real-time RT-PCR, and western blotting...
April 13, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29650250/thermo-setting-glass-ionomer-cements-promote-variable-biological-responses-of-human-dental-pulp-stem-cells
#14
Mar Collado-González, Miguel R Pecci-Lloret, Christopher J Tomás-Catalá, David García-Bernal, Ricardo E Oñate-Sánchez, Carmen Llena, Leopoldo Forner, Vinicius Rosa, Francisco J Rodríguez-Lozano
OBJECTIVE: To evaluate the in vitro cytotoxicity of Equia Forte (GC, Tokyo, Japan) and Ionostar Molar (Voco, Cuxhaven, Germany) on human dental pulp stem cells (hDPSCs). METHODS: hDPSCs isolated from third molars were exposed to several dilutions of Equia Forte and Ionostar Molar eluates (1/1, 1/2 and 1/4). These eluates were obtained by storing material samples in respective cell culture medium for 24h (n=40). hDPSCs in basal growth culture medium were the control...
April 9, 2018: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/29643528/-comparison-of-the-properties-of-cd146-positive-and-cd146-negative-subpopulations-of-stem-cells-from-human-exfoliated-deciduous-teeth
#15
X T Wang, N Q Rao, T Jz Fang, Y M Zhao, L H Ge
OBJECTIVE: Stem cells from human exfoliated teeth (SHED) were sorted by magnetically activated cell sorting (MACS) technique to obtain the CD146 positive and negative cell subpopulation. Then the biological characteristics of these subpopulations were compared to explore their specific application potential in tissue engineering. METHODS: In this study, freshly extracted deciduous teeth without any caries or dental pulp disease were obtained. SHED was isolated using enzyme digestion method and then sorted by MACS, CD146 positive cells and CD146 negative cells were obtained after cell sorting...
April 18, 2018: Beijing da Xue Xue Bao. Yi Xue Ban, Journal of Peking University. Health Sciences
https://www.readbyqxmd.com/read/29628652/development-of-a-dual-cure-mineral-trioxide-aggregate-based-cement-biological-physical-and-mechanical-properties
#16
Laura Siqueira Pintado, Eliana do Nascimento Torre, Maicon Dos Santos Selayaran, Rodrigo Varella de Carvalho, Cesar Henrique Zanchi, Fábio Renato Manzolli Leite, Adriana Etges
Purpose: The purpose of this study is to compare the physical, mechanical, and biocompatibility properties of a new dual-cure white mineral trioxide aggregate (D-W-MTA) and a commercial W-MTA. Materials and Methods: Diametral tensile strength (DTS), water sorption (WSp), and water solubility (WSl) tests were performed. Cytotoxicity was observed in primary culture of human pulp fibroblasts (HPFs) and mouse 3T3/NIH fibroblast lineage. Specimens of both materials were embedded in 1 mL of Dulbecco's modified essential medium for 24 h...
January 2018: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29621667/a-comprehensive-analysis-of-human-dental-pulp-cell-spheroids-in-a-three-dimensional-pellet-culture-system
#17
Siyuan Zhang, Patricia Buttler-Buecher, Bernd Denecke, Victor E Arana-Chavez, Christian Apel
OBJECTIVE: Three-dimensional (3D) cell culture methods are of high importance to studies of biological processes. This is particularly the case with spheroid cultures, which create 3D cell aggregates without the use of exogenous materials. Compared to conventional monolayer cultures, cellular spheroid cultures have been demonstrated to improve multilineage potential and extracellular matrix production. To address this issue in depth, we present a more comprehensive analysis of 3D human dental pulp cell (hDPC) spheroids...
February 15, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29605254/low-fibrillated-bacterial-cellulose-nanofibers-as-a-sustainable-additive-to-enhance-recycled-paper-quality
#18
Cristina Campano, Noemi Merayo, Carlos Negro, Ángeles Blanco
Bacterial cellulose is a biological macromolecule synthesized by bacteria of high purity and crystallinity. Bacterial cellulose nanofibers (BCNF) have been produced by soft homogenization and added to a recycled pulp to improve its quality. The benefits of BCNF on mechanical, physical and optical paper properties have been quantified and the retention mechanism of the BCNF in the paper network has been proposed. The use of BC to improve paper strength is usually limited by the decrease of tear index. The novelty of this work is that these two effects are decoupled by the addition of BCNF of low fibrillation (35...
March 29, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29571457/a-multi-methodological-approach-in-the-study-of-italian-pdo-cornetto-di-pontecorvo-red-sweet-pepper
#19
Anatoly P Sobolev, Luisa Mannina, Donatella Capitani, Gabriella Sanzò, Cinzia Ingallina, Bruno Botta, Simonetta Fornarini, Maria Elisa Crestoni, Barbara Chiavarino, Simone Carradori, Marcello Locatelli, Anna Maria Giusti, Giovanna Simonetti, Giuliana Vinci, Raffaella Preti, Chiara Toniolo, Massimo Reverberi, Marzia Scarpari, Alessia Parroni, Lorena Abete, Fausta Natella, Antonella Di Sotto
A multi-methodological approach was applied to study red sweet peppers (Capsicum annuum L.) ecotype "Cornetto di Pontecorvo" grown in a greenhouse or in open field. This approach includes morphological analysis, chemical composition determination, and biological activity evaluation of different extracts from pepper fruits. Untargeted analyses, namely NMR spectroscopy and mass spectrometry, allowed the comprehensive pepper metabolite profile of pepper pulp, peel and seeds hydroalcoholic and organic extracts to be determined, showing the presence of sugars, organic acids, amino acids and other secondary metabolites...
July 30, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29570806/preparation-of-citrus-pectin-gels-by-power-ultrasound-and-its-application-as-edible-coating-in-strawberries
#20
Ana M Muñoz-Labrador, Rodrigo Moreno, Mar Villamiel, Antonia Montilla
BACKGROUND: Pectin is heteropolysaccharide found in cell walls coming mainly from by-products as well as citrus peels, apple and sugar beet pulp and presenting biological and techno-functional properties. In this work a generalproximal and structural characterisation of industrial citrus pectins was done together with a study of impact of power ultrasound (US) on their rheological properties with the aim of using them as edible coatings for fresh strawberries. RESULTS: The results indicated that pure pectin showed a methylesterification degree greater than 50% and galacturonic acid content > 65%, indicating its consideration as additive E-440, conditions that were not achieved by pectin with sugar addition...
March 23, 2018: Journal of the Science of Food and Agriculture
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