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https://www.readbyqxmd.com/read/28409013/lay-beliefs-about-hypertension-among-hiv-infected-adults-in-kenya
#1
Tecla M Temu, Ehete Bahiru, Fredrick Bukachi, Gerald S Bloomfield, Peter Muiruri, Carey Farquhar
OBJECTIVE: Hypertension affects 23% of Kenyans and is the most prevalent modifiable risk factor for cardiovascular disease. Despite this, hypertension awareness and treatment adherence is very low. We conducted a qualitative study to explore lay beliefs about hypertension among HIV-infected adults to inform the development of culture sensitive hypertension prevention and control program. METHODS: Eight focus group discussions were held for 53 HIV-infected adults at the HIV clinic in Kenya...
2017: Open Heart
https://www.readbyqxmd.com/read/28384660/association-between-hiv-infection-and-the-risk-of-heart-failure-with-reduced-ejection-fraction-and-preserved-ejection-fraction-in-the-antiretroviral-therapy-era-results-from-the-veterans-aging-cohort-study
#2
Matthew S Freiberg, Chung-Chou H Chang, Melissa Skanderson, Olga V Patterson, Scott L DuVall, Cynthia A Brandt, Kaku A So-Armah, Ramachandran S Vasan, Kris Ann Oursler, John Gottdiener, Stephen Gottlieb, David Leaf, Maria Rodriguez-Barradas, Russell P Tracy, Cynthia L Gibert, David Rimland, Roger J Bedimo, Sheldon T Brown, Matthew Bidwell Goetz, Alberta Warner, Kristina Crothers, Hilary A Tindle, Charles Alcorn, Justin M Bachmann, Amy C Justice, Adeel A Butt
Importance: With improved survival, heart failure (HF) has become a major complication for individuals with human immunodeficiency virus (HIV) infection. It is unclear if this risk extends to different types of HF in the antiretroviral therapy (ART) era. Determining whether HIV infection is associated with HF with reduced ejection fraction (HFrEF), HF with preserved ejection fraction (HFpEF), or both is critical because HF types differ with respect to underlying mechanism, treatment, and prognosis...
April 5, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28379043/hiv-and-risk-of-cardiovascular-disease-in-sub-saharan-africa-rationale-and-design-of-the-ndlovu-cohort-study
#3
Alinda Vos, Hugo Tempelman, Walter Devillé, Roos Barth, Annemarie Wensing, Mirjam Kretzschmar, Kerstin Klipstein-Grobusch, Andy Hoepelman, Kiki Tesselaar, Sue Aitken, Mashudu Madzivhandila, Cuno Uiterwaal, Francois Venter, Roel Coutinho, Diederick E Grobbee
Background The largest proportion of people living with HIV resides in sub-Saharan Africa (SSA). Evidence from developed countries suggests that HIV infection increases the relative risk of cardiovascular disease (CVD) by up to 50%. Differences in lifestyle, gender distribution, routes of HIV transmission and HIV subtype preclude generalisation of data from Western countries to the SSA situation. The Ndlovu Cohort Study aims to provide insight into the burden of cardiovascular risk factors and disease, the mechanisms driving CVD risk and the contribution of HIV infection and its treatment to the development of CVD in a rural area of SSA...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28290995/uses-of-polypills-for-cardiovascular-disease-and-evidence-to-date
#4
REVIEW
Mark D Huffman, Denis Xavier, Pablo Perel
Polypills have been approved in more than 30 countries, but worldwide experience with and availability of polypills remain limited, unlike fixed-dose combinations in other diseases such as HIV, tuberculosis, and malaria. In this Series review, we aim to propose a guide for the use of polypills in future research and clinical activities and to synthesise contemporary evidence supporting the use of polypills for prevention of atherosclerosis. Polypill uses can be categorised by population and indication, both of which influence the balance between benefits and risks...
March 11, 2017: Lancet
https://www.readbyqxmd.com/read/28285796/cardiovascular-disease-in-women-with-hiv-1-infection
#5
Massimo Volpe, Alessia Uglietti, Antonella Castagna, Cristina Mussini, Giulia Marchetti, Rita Bellagamba, Teresa Bini, Daniela Mancusi, Roberta Termini
Cardiovascular disease is a leading cause of death in women, nevertheless it is often underestimated in female patients without overt risk factors. The chronic infection by Human Immunodeficiency Virus (HIV) is clearly associated, along with the use of certain antiretroviral drugs and traditional risk factors, with an increased risk of cardiovascular diseases. The aim of this manuscript is to review the epidemiology, risk factors, pathogenesis, diagnostic approach, primary and secondary prevention strategies of cardiovascular disease in HIV-negative and HIV-positive female subjects...
February 27, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28060868/non-communicable-disease-preventive-screening-by-hiv-care-model
#6
Corinne M Rhodes, Yuchiao Chang, Susan Regan, Virginia A Triant
IMPORTANCE: The Human Immunodeficiency Virus (HIV) epidemic has evolved, with an increasing non-communicable disease (NCD) burden emerging and need for long-term management, yet there are limited data to help delineate the optimal care model to screen for NCDs for this patient population. OBJECTIVE: The primary aim was to compare rates of NCD preventive screening in persons living with HIV/AIDS (PLWHA) by type of HIV care model, focusing on metabolic/cardiovascular disease (CVD) and cancer screening...
2017: PloS One
https://www.readbyqxmd.com/read/28052152/types-of-myocardial-infarction-among-human-immunodeficiency-virus-infected-individuals-in-the-united-states
#7
Heidi M Crane, Pathmaja Paramsothy, Daniel R Drozd, Robin M Nance, J A Chris Delaney, Susan R Heckbert, Matthew J Budoff, Greer A Burkholder, James H Willig, Michael J Mugavero, William C Mathews, Paul K Crane, Richard D Moore, Joseph J Eron, Sonia Napravnik, Peter W Hunt, Elvin Geng, Priscilla Hsue, Carla Rodriguez, Inga Peter, Greg S Barnes, Justin McReynolds, William B Lober, Kristina Crothers, Matthew J Feinstein, Carl Grunfeld, Michael S Saag, Mari M Kitahata
Importance: The Second Universal Definition of Myocardial Infarction (MI) divides MIs into different types. Type 1 MIs result spontaneously from instability of atherosclerotic plaque, whereas type 2 MIs occur in the setting of a mismatch between oxygen demand and supply, as with severe hypotension. Type 2 MIs are uncommon in the general population, but their frequency in human immunodeficiency virus (HIV)-infected individuals is unknown. Objectives: To characterize MIs, including type; identify causes of type 2 MIs; and compare demographic and clinical characteristics among HIV-infected individuals with type 1 vs type 2 MIs...
March 1, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28051979/barriers-and-health-beliefs-related-to-weight-management-among-veterans-with-human-immunodeficiency-virus
#8
Shannon Munro, Emily Dinatale, Sarah Hartley, Monica St Jacques, Kris Ann Oursler
INTRODUCTION: The success of antiretroviral therapy has led to dramatic changes in causes of morbidity and mortality among U.S. Veterans with human immunodeficiency virus (HIV). Among the 25,000 Veterans treated for HIV, 70% are over age 50 and the rate of obesity has doubled in this population. Veterans with HIV have a 50% increased risk of myocardial infarction yet have limited presence in prevention-related programs designed to lower cardiovascular disease risk. METHODS: This mixed methods study (focus groups, Schwarzer and Renner physical activity, and nutrition self-efficacy questionnaires) was used to explore factors related to health behavior and identify barriers that overweight Veterans with HIV face in enrolling in the MOVE weight management program...
January 2017: Military Medicine
https://www.readbyqxmd.com/read/27955664/the-burden-of-hypertension-diabetes-mellitus-and-cardiovascular-risk-factors-among-adult-malawians-in-hiv-care-consequences-for-integrated-services
#9
Oscar H Divala, Alemayehu Amberbir, Zahra Ismail, Teferi Beyene, Daniela Garone, Colin Pfaff, Victor Singano, Harriet Akello, Martias Joshua, Moffat J Nyirenda, Alfred Matengeni, Josh Berman, Jane Mallewa, Gift S Chinomba, Noel Kayange, Theresa J Allain, Adrienne K Chan, Sumeet K Sodhi, Joep J van Oosterhout
BACKGROUND: Hypertension and diabetes prevalence is high in Africans. Data from HIV infected populations are limited, especially from Malawi. Integrating care for chronic non-communicable co-morbidities in well-established HIV services may provide benefit for patients by preventing multiple hospital visits but will increase the burden of care for busy HIV clinics. METHODS: Cross-sectional study of adults (≥18 years) at an urban and a rural HIV clinic in Zomba district, Malawi, during 2014...
December 12, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27860212/alcohol-and-dietary-factors-associate-with-gut-integrity-and-inflammation-in-hiv-infected-adults
#10
A R Webel, A Sattar, N T Funderburg, B Kinley, C T Longenecker, D Labbato, Sm Khurshid Alam, G A McComsey
OBJECTIVES: HIV-infected adults have heightened monocyte activation and inflammation, at least partially as a consequence of altered gut integrity. The role of dietary factors in microbial translocation and inflammation and their downstream effect on markers of cardiovascular disease (CVD) have not been explored. Our purpose was to describe the longitudinal dietary patterns of HIV-infected adults, and to examine the relationship between dietary intake, gut integrity, inflammation and subclinical markers of CVD in HIV-infected adults...
November 9, 2016: HIV Medicine
https://www.readbyqxmd.com/read/27623022/tetrahydroisoquinolines-in-therapeutics-a-patent-review-2010-2015
#11
REVIEW
Inder Pal Singh, Purvi Shah
1,2,3,4-Tetrahydroisoquinoline (THIQ) is one of the 'privileged scaffolds', commonly found in nature. Initially, this class of compounds was known for its neurotoxicity. Later on, 1-methyl-1,2,3,4-tetrahydroisoquinoline was proved as an endogeneous Parkinsonism-preventing agent in mammals. The fused THIQs have been studied for their role as anticancer antibiotics. The US FDA approval of the trabectedin for the treatment of soft tissue sarcomas, is a milestone in the anticancer drug discovery. Areas covered: This review covers the patents on various therapeutic activities of the THIQ derivatives in the years between 2010 and 2015...
January 2017: Expert Opinion on Therapeutic Patents
https://www.readbyqxmd.com/read/27438424/hiv-and-hepatitis-c-virus-coinfection-who-is-this-patient-today
#12
Vicente Sperb Antonello, Ivan Carlos Ferreira Antonello, Rosana Ferrazza Zaltron, Cristiane Valle Tovo
BACKGROUND: - The increase in the survival following the introduction of highly active antiretroviral therapy (HAART) has seen the emergence of hepatitis C virus (HCV) infection, renal and cardiovascular diseases as important morbidity and mortality causes together with HIV. OBJECTIVE: - The present study aimed to investigate the differences between HIV/hepatitis C virus coinfected and HIV-monoinfected regarding demographic and clinical aspects from a HIV/AIDS clinic in Porto Alegre, Brazil...
July 2016: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/27390962/a-plausible-causal-link-between-antiretroviral-therapy-and-increased-blood-pressure-in-a-sub-saharan-african-setting-a-propensity-score-matched-analysis
#13
Chidozie U Nduka, Saverio Stranges, Gerald S Bloomfield, Peter K Kimani, Godwin Achinge, Abraham O Malu, Olalekan A Uthman
BACKGROUND: The transition from association to causation could represent a fundamental step for taking preventive action against hypertension and its complications, especially among HIV-infected persons on antiretroviral therapy in sub-Saharan African countries. METHODS: 406 consecutive HIV-infected adults attending a tertiary HIV clinic in semi-urban Nigeria were prospectively recruited between August and November 2014. These participants were stratified by antiretroviral treatment status...
October 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27355105/outcomes-of-patients-in-long-term-opioid-maintenance-treatment
#14
Bettina Zippel-Schultz, Michael Specka, Konrad Cimander, Thomas Eschenhagen, Jörg Gölz, Markus Maryschok, Manfred Nowak, Thomas Poehlke, Heino Stöver, Thomas M Helms, Norbert Scherbaum
BACKGROUND: Despite the importance of duration of opioid maintenance treatment (OMT), only few studies have reported outcomes of long-term OMT. OBJECTIVES: To describe outcomes of long-term (> 5 years) OMT patients with respect to substance use, physical and mental health, and socioeconomic characteristics. METHODS: Patients (n = 160) were recruited from 15 OMT offices in different regions of Germany. Data were collected using a structured interview at baseline, and clinical recordings, including urine drug screenings, during 12 monhts follow-up...
September 18, 2016: Substance Use & Misuse
https://www.readbyqxmd.com/read/27267576/a-summary-of-the-first-hiv-microbiome-workshop-2015
#15
Brett Williams, Paria Mirmonsef, Charles A B Boucher, Frederic Bushman, Stacy Carrington-Lawrence, Ronald G Collman, Satya Dandekar, Que Dang, Angela Malaspina, Roger Paredes, Arthur Stone, Alan Landay
The role of microbiota in the pathogenesis of HIV infection has become the subject of intense research in recent years. A rapidly growing amount of data suggests that microbial dysbiosis-in the gut or the genital tract-can influence HIV transmission and/or disease progression; however a deeper understanding of the mechanisms involved is lacking. To better understand the relationship between the microbiome and HIV infection, investigators from a wide variety of disciplines including those working in basic and clinical HIV studies, cardiovascular disease, reproductive health and bioinformatics gathered at the first International workshop on Microbiome in HIV Pathogenesis, Prevention and Treatment, at NIH on 7 and 8 April 2015...
June 7, 2016: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/27158629/challenges-facing-successful-scaling-up-of-effective-screening-for-cardiovascular-disease-by-community-health-workers-in-mexico-and-south-africa-policy-implications
#16
Abrahams-Gessel S, C A Denman, Gaziano Ta, Levitt Ns, Puoane T
The integration of community health workers (CHWs) into primary and secondary prevention functions in health programs and services delivery in Mexico and South Africa has been demonstrated to be effective. Task-sharing related to adherence and treatment, from nurses to CHWs, has also been effectively demonstrated in these areas. HIV/AIDS and TB programs in South Africa have seen similar successes in task-sharing with CHWs in the areas of screening for risk and adherence to treatment. In the area of non-communicable diseases (NCDs), there is a policy commitment to integrating CHWs into primary health care programs at public health facilities in both Mexico and South Africa in the areas of reproductive health and infant health...
2016: Health Systems and Policy Research
https://www.readbyqxmd.com/read/27147266/obesity-in-the-hiv-infected-population-in-northeast-england-a-particular-issue-in-black-african-women
#17
C Ilozue, B Howe, S Shaw, K Haigh, J Hussey, D A Price, D R Chadwick
People living with HIV are surviving longer on successful antiretroviral therapy and obesity rates are increasing. We sought to determine the prevalence of being overweight or obese in a regional population of people living with HIV and to explore the demographic and clinical characteristics associated with obesity or being overweight. Data on patients attending three Northeast England clinics were collected including body mass index and demographics. The prevalence of being overweight (body mass index ≥ 25 kg/m(2)) or obese (body mass index ≥ 30 kg/m(2)) was determined and compared with regional population data...
March 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/27143663/statin-utilization-and-recommendations-among-hiv-and-hcv-infected-veterans-a-cohort-study
#18
Meredith E Clement, Lawrence P Park, Ann Marie Navar, Nwora Lance Okeke, Michael J Pencina, Pamela S Douglas, Susanna Naggie
BACKGROUND: Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections are associated with increased risk of cardiovascular disease (CVD). The potential impact of recently updated cholesterol guidelines on treatment of HIV- and HCV-infected veterans is unknown. METHODS: We performed a retrospective cohort study to assess statin use and recommendations among 13 579 HIV-infected, 169 767 HCV-infected, and 6628 HIV/HCV-coinfected male veterans aged 40-75 years...
August 1, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27090989/hypertension-among-hiv-infected-patients-in-clinical-care-1996-2013
#19
Nwora Lance Okeke, Thibaut Davy, Joseph J Eron, Sonia Napravnik
BACKGROUND: Persons infected with human immunodeficiency virus (HIV) are at higher risk for major cardiovascular disease (CVD) events than uninfected persons. Understanding the epidemiology of major traditional CVD risk determinants, particularly hypertension, in this population is needed. METHODS: The study population included HIV-infected patients participating in the UNC CFAR HIV Clinical Cohort from 1996 to 2013. Annual incidence rates of hypertension were calculated...
July 15, 2016: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/27059051/jazzin-healthy-interdisciplinary-health-outreach-events-focused-on-disease-prevention-and-health-promotion
#20
Diana Isaacs, Angela C Riley, Lalita Prasad-Reddy, Rebecca Castner, Heather Fields, Deborah Harper-Brown, Sabah Hussein, Charisse L Johnson, Traiana Mangum, Sneha Srivastava
OBJECTIVES: Health-related disparities are a significant public health concern. In conjunction with a university concert series, healthcare professionals and students provided education, clinical services, and preventive care using an interdisciplinary approach to a primarily African American cohort. The objective was to assess cardiovascular risk factors and readiness to change health-related behaviors. METHODS: Six outreach events were conducted over 3 years by an interdisciplinary team including pharmacy, medicine, nursing, nutrition, occupational therapy, public health, optometry, and health information technology...
April 2017: Journal of Racial and Ethnic Health Disparities
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