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Plaque composition

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https://www.readbyqxmd.com/read/29161371/long-term-remineralizing-effect-of-mi-paste-plus-on-regression-of-early-caries-after-orthodontic-fixed-appliance-treatment-a-12-month-follow-up-randomized-controlled-trial
#1
Moniek W Beerens, Jacob M Ten Cate, Mark J Buijs, Monique H van der Veen
Background: Casein-phosphopeptide-amorphous-calcium-fluoride-phosphate (CPP-ACFP) can remineralize subsurface lesions. It is the active ingredient of MI-Paste-Plus® (MPP). The long-term remineralization efficacy is unknown. Objective: To evaluate the long-term effect of MPP versus a placebo paste on remineralization of enamel after fixed orthodontic treatment over a 12-month period. Design: This trial was designed as a prospective, double-blinded, placebo-controlled RCT...
November 17, 2017: European Journal of Orthodontics
https://www.readbyqxmd.com/read/29160346/effect-of-tio2-nanoparticles-incorporation-on-antibacterial-properties-and-shear-bond-strength-of-dental-composite-used-in-orthodontics
#2
Ahmad Sodagar, Mohamad Sadegh Ahmad Akhoundi, Abbas Bahador, Yasamin Farajzadeh Jalali, Zahra Behzadi, Farideh Elhaminejad, Amir Hossein Mirhashemi
INTRODUCTION: Plaque accumulation and bond failure are drawbacks of orthodontic treatment, which requires composite for bonding of brackets. As the antimicrobial properties of TiO2 nanoparticles (NPs) have been proven, the aim of this study was to evaluate the antimicrobial and mechanical properties of composite resins modified by the addition of TiO2 NPs. METHODS: Orthodontics composite containing 0%, 1%, 5% and 10% NPs were prepared. 180 composite disks were prepared for elution test, disk agar diffusion test and biofilm inhibition test to collect the counts of microorganisms on three days, measure the inhibition diameter and quantify the viable counts of colonies consequently...
September 2017: Dental Press Journal of Orthodontics
https://www.readbyqxmd.com/read/29156421/impaired-mitochondrial-respiration-in-human-carotid-plaque-atherosclerosis-a-potential-role-for-pink1-in-vascular-smooth-muscle-cell-energetics
#3
Craig K Docherty, Andy Carswell, Elaine Friel, John R Mercer
BACKGROUND AND AIMS: DNA damage and mitochondrial dysfunction are thought to play an essential role in ageing and the energetic decline of vascular smooth muscle cells (VSMCs) essential for maintaining plaque integrity. We aimed to better understand VSMCs and identify potentially useful compensatory pathways that could extend their lifespan. Moreover, we wanted to assess if defects in mitochondrial respiration exist in human atherosclerotic plaques and to identify the appropriate markers that may reflect a switch in VSMC energy metabolism...
November 13, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29155022/vmg-ii-transport-medium-stabilises-oral-microbiome-samples-for-next-generation-sequencing
#4
Christina J Adler, Abbe White, Michelle Bockmann, Gina V Browne, Grant Townsend, Toby Hughes
Next-Generation Sequencing is providing insights into the critical role of the oral microbiome in dental diseases. Application of this method can require the collection of dental plaque from large cohorts in field-type conditions, which necessitates a transport medium to preserve the microbiome composition. We evaluated the use of two transport media, VMG II and RNAprotect® Bacteria Reagent (Qiagen), for room temperature storage of dental plaque. VMG II has not previously been assessed for suitability to store microbiome samples intended for deep sequencing...
November 15, 2017: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29137053/prognostic-value-of-high-resolution-magnetic-resonance-imaging-in-evaluating-carotid-atherosclerotic-plaque-in-patients-with-ischemic-stroke
#5
Jin-Er Shu, Ming-Liang Ying, Xiao-Rong Chen, Jian-Jun Hua, Jie-Ting Fu, Xiu-Mei Xia, Yong-Hao Pan, Yang Jiang
BACKGROUND: Ischemic stroke (IS) is a devastating occurrence affecting millions worldwide. This study aimed to evaluate the prognostic value of high-resolution magnetic resonance imaging (HRMRI) in assessing carotid atherosclerotic plaque in IS patients. METHODS: Between January 2013 and March 2015, 338 IS patients were recruited for the investigative purposes of the study. All participants of the study underwent an HRMRI inspection procedure after being admitted into the hospital...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29135482/long-term-darapladib-use-does-not-affect-coronary-plaque-composition-assessed-using-multimodality-intravascular-imaging-modalities-a-randomized-controlled-study
#6
Woong Gil Choi, Megha Prasad, Ryan Lennon, Rajiv Gulati, Abhiram Prasad, Lilach O Lerman, Amir Lerman
BACKGROUND: Lipoprotein-associated phospholipase A2 (Lp-PLA2) may play a role in plaque progression and vulnerability. We aimed to define plaque characteristics on multimodality intravascular imaging in patients with coronary endothelial dysfunction in response to long-term inhibition of Lp-PLA2 by darapladib. PATIENTS AND METHODS: This is a double-blinded, randomized study screening 70 patients, and enrolling 54 patients with suspected ischemia, without obstructive disease on angiography and with coronary endothelial dysfunction by invasive assessment...
November 10, 2017: Coronary Artery Disease
https://www.readbyqxmd.com/read/29132853/assessing-clinical-response-and-defining-minimal-disease-activity-in-plaque-psoriasis-with-the-physician-global-assessment-and-body-surface-area-pga%C3%A2-%C3%A3-%C3%A2-bsa-composite-tool-an-analysis-of-apremilast-phase-3-esteem-data
#7
Alice B Gottlieb, Joseph F Merola, Rongdean Chen, Eugenia Levi, Kristina Callis Duffin
No abstract text is available yet for this article.
December 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/29129602/standardized-fraction-of-xylocarpus-moluccensis-fruits-improve-vascular-relaxation-and-plaque-stability-in-dyslipidemic-models-of-atherosclerosis
#8
Jitendra S Kanshana, Sanjay C Rebello, Priya Pathak, Babu Nageswararao Kanuri, Hobby Aggarwal, Vasundhara Srivastava, Vivek Khanna, Vishal Singh, Kumaravelu Jagavelu, Manoj K Barthwal, Madhu Dikshit
ETHNOPHARMACOLOGICAL RELEVANCE: Xylocarpus moluccensis (Lamk.) M. Roem of family Meliaceae has triterpenoids rich fruits. Triterpenoids have been known to possess cardioprotection and anti-atherosclerotic activities (Han and Bakovic, 2015; Wu et al., 2009). Standardized fraction of these fruits exhibited anti-dyslipidemic (Srivastava et al., 2015), anti-inflammatory (Ravangpai et al., 2011) and CNS depressant activity (Sarker et al., 2007). However, there is no report in the literature on its cardiovascular effects...
November 10, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29129081/identification-of-mature-atherosclerotic-plaque-proteome-signatures-using-data-independent-acquisition-mass-spectrometry
#9
Nicole Hansmeier, Josef Buttigieg, Pankaj Kumar, Shaneen Pelle, Kyoo Yoon Choi, David Kopriva, Tzu-Chiao Chao
Atherosclerosis is a chronic inflammatory disease with complex pathobiology and one of the most common causes of cardiovascular events. The process is characterized by complex vascular remodeling processes that require the actions of numerous proteins. The composition of atherosclerotic plaque is increasingly recognized as a major factor governing the occurrence of cardiovascular or neurological symptoms. In order to gain deeper insights in the composition of atherosclerotic plaques, we created quantitative proteome profiles of advanced plaque tissues of six male patients undergoing carotid endarterectomy for stroke prevention...
November 11, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29114222/ginsenoside-rb1-enhances-atherosclerotic-plaque-stability-by-improving-autophagy-and-lipid-metabolism-in-macrophage-foam-cells
#10
Lei Qiao, Xue Zhang, Minghao Liu, Xiaoling Liu, Mei Dong, Jing Cheng, Xinyu Zhang, Chungang Zhai, Yu Song, Huixia Lu, Wenqiang Chen
Atherosclerosis (AS) is a lipid-driven disease in which macrophage foam cells play a critical role by increasing vascular lipid accumulation and contributing to plaque instability. Ginsenoside Rb1 (Rb1), the most abundant active component of ginseng, has been found potently to promote lipid metabolism and attenuate lipid accumulation. However, the underlying mechanisms remain unclear. In this study, the effects of Rb1 on lipid accumulation and plaque stability were investigated both in vitro and in vivo by using primary peritoneal macrophages isolated from C57BL/6 mice and an AS model in ApoE(-/-) mice...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29109747/effect-of-finishing-polishing-techniques-and-time-on-surface-roughness-of-esthetic-restorative-materials
#11
Prashanthi Sampath Madhyastha, Shreya Hegde, N Srikant, Ravindra Kotian, Srividhya Sriraman Iyer
Background: Surface roughness associated with improper finishing/polishing of restorations can result in plaque accumulation, gingival irritation, surface staining, and poor esthetic of restored teeth. The study aimed to evaluate the efficiency of various finishing and polishing systems and time using various procedures on surface roughness of some esthetic restorative materials. Materials and Methods: In this in vitro study, samples of two composite materials, compomer and glass ionomer cement (GIC) materials, were fabricated...
September 2017: Dental Research Journal
https://www.readbyqxmd.com/read/29103477/atherosclerotic-plaque-features-and-distribution-in-bilateral-carotid-arteries-of-asymptomatic-elderly-population-a-3d-multicontrast-mr-vessel-wall-imaging-study
#12
Ying Cai, Le He, Chun Yuan, Huijun Chen, Qiang Zhang, Rui Li, Cheng Li, Xihai Zhao
PURPOSE: This study sought to investigate the characteristics of morphology, compositions and distribution of carotid atherosclerotic plaques in asymptomatic elderly population using three dimensional (3D) multicontrast magnetic resonance vessel wall imaging. MATERIALS AND METHODS: 146 asymptomatic elderly subjects (≥60years) were recruited and underwent 3D multicontrast MR vessel wall imaging for bilateral carotid arteries on a 3.0T MR scanner. The presence of carotid atherosclerotic plaque was determined and the stenosis was measured...
November 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/29097437/associations-of-endogenous-estradiol-and-testosterone-levels-with-plaque-composition-and-risk-of-stroke-in-subjects-with-carotid-atherosclerosis
#13
Marija Glisic, Blerim Mujaj, Oscar L Rueda-Ochoa, Eralda Asllanaj, Joop S Laven, Maryam Kavousi, M Kamran Ikram, Meike W Vernooij, M Arfan Ikram, Oscar H Franco, Daniel Bos, Taulant Muka
Rationale: Sex steroids may play a role in plaque composition and in stroke incidence. Objective: To study the associations of endogenous estradiol and testosterone with carotid plaque composition in elderly men and postmenopausal women with carotid atherosclerosis, as well as with risk of stroke in this population. Methods and Results: Data of 1023 postmenopausal women and 1124 men (≥45 years) with carotid atherosclerosis, from prospective population-based Rotterdam Study, were available. At baseline, total estradiol (TE) and total testosterone (TT) were measured...
November 2, 2017: Circulation Research
https://www.readbyqxmd.com/read/29089763/a-review-of-molecular-imaging-of-atherosclerosis-and-the-potential-application-of-dendrimer-in-imaging-of-plaque
#14
REVIEW
Gulinigaer Anwaier, Cong Chen, Yini Cao, Rong Qi
Despite the fact that technological advancements have been made in diagnosis and treatment, cardiovascular diseases (CVDs) remain the leading cause of mortality and morbidity worldwide. Early detection of atherosclerosis (AS), especially vulnerable plaques, plays a crucial role in the prevention of acute coronary syndrome (ACS). Targeting the critical cytokines and molecules that are upregulated during the biological process of AS by in vivo molecular imaging has been widely used in plaque imaging. With their three-dimensional architecture, composition, and abundant terminal functional groups, dendrimers provide a platform for multitargeting and multimodal imaging...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29081913/effect-of-maltitol-containing-chewing-gum-use-on-the-composition-of-dental-plaque-microbiota-in-subjects-with-active-dental-caries
#15
Erica M Prosdocimi, James O Kistler, Rebecca Moazzez, Clementine Thabuis, Caroline Perreau, William G Wade
Background: Sugar alcohols such as xylitol are incorporated in a number of oral hygiene products for their anti-cariogenic properties while chewing gum is known to be beneficial to oral hygiene. Objective: The aim of this study was to determine the composition of the dental plaque microbiota in patients with active caries before and after using a chewing gum supplemented with maltitol. Design : Forty subjects with active caries were randomly allocated to chew maltitol gum or gum base for two weeks. A healthy control group used gum base for two weeks...
2017: Journal of Oral Microbiology
https://www.readbyqxmd.com/read/29076745/cost-effectiveness-of-magnetic-resonance-carotid-plaque-imaging-for-primary-stroke-prevention-in-canada
#16
Lechtman E, Balki I, Thomas K, Chen K, Moody Ar, Tyrrell Pn
OBJECTIVE: Magnetic resonance of the carotid arteries provides important insight into plaque composition and vulnerability in addition to the traditional measure of stenosis. The purpose of this study was to evaluate the cost-effectiveness of MR imaging as a first-line modality to assess carotid disease and guide management for high-risk patients with <50% stenosis. METHODS: Using TreeAge Pro, a cost-effectiveness simulation was conducted comparing two strategies: (a) standard of care first-line carotid duplex ultrasound (DUS) with regular follow-up, vs (b) first-line MR assessment of stenosis and intraplaque haemorrhage (MRIPH) in which patients with IPH received annual DUS surveillance and immediate carotid endarterectomy in case of plaque progression...
November 21, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29064537/in-stent-restenosis-prone-coronary-plaque-composition-a-retrospective-virtual-histology-intravascular-ultrasound-study
#17
Duck-Jun Seo, Yong-Kyun Kim, Young-Hoon Seo, In-Geol Song, Ki-Hong Kim, Taek-Geun Kwon, Hyun-Woong Park, Jang-Ho Bae
BACKGROUND: The mechanism of in-stent restenosis (ISR) is multifactorial, which includes biological, mechanical and technical factors. This study hypothesized that increased inflammatory reaction, which is known to be an important atherosclerotic process, at a culprit lesion may lead to higher restenosis rates. METHODS: The study population consisted of 241 patients who had undergone percutaneous coronary intervention with virtual histology-intravascular ultrasound (VH-IVUS) and a 9-month follow-up coronary angiography...
October 24, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/29061380/influence-of-cervical-margin-relocation-cmr-on-periodontal-health-12-month-results-of-a-controlled-trial
#18
Marco Ferrari, Serhat Koken, Simone Grandini, Edoardo Ferrari Cagidiaco, Tim Joda, Nicola Discepoli
OBJECTIVES: The concept of Cervical Margin Relocation (CMR) consists on placing a base layer of direct resin composite to elevate supra-gingivally the proximal indirect bonded restorations. The aims of this clinical study were to evaluate 1. Bleeding on Probing (BoP) on posterior indirect restorations with one interproximal margin relocated cervically, and 2. possible correlation between depth of the interproximal margins and BoP. METHODS: CMR (Group 1) and shoulder preparations (Group 2) were performed in 35 posterior teeth and evaluated after 12 months (T12)...
October 20, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/29060525/arfi-variance-of-acceleration-voa-for-noninvasive-characterization-of-human-carotid-plaques-in-vivo
#19
Gabriela Torres, Tomasz J Czernuszewicz, Jonathon W Homeister, Mark A Farber, Caterina M Gallippi
Rather than degree of stenosis, assessing plaque structure and composition is relevant to discerning risk for plaque rupture with downstream ischemic event. The structure and composition of carotid plaque has been assessed noninvasively using Acoustic Radiation Force Impulse (ARFI) ultrasound imaging. In particular, ARFI-derived peak displacement (PD) estimations have been demonstrated for discriminating soft (lipid rich necrotic core (LRNC) or intraplaque hemorrhage (IPH)) from stiff (collagen (COL) or calcium (CAL)) plaque features; however, PD did not differentiate LRNC from IPH or COL from CAL...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29055637/impact-of-pre-diabetes-on-coronary-plaque-composition-and-clinical-outcome%C3%A2-in-patients-with-acute-coronary%C3%A2-syndromes-an-analysis-from-the-prospect-study
#20
Serdar Farhan, Björn Redfors, Akiko Maehara, Thomas McAndrew, Ori Ben-Yehuda, Bernard De Bruyne, Roxana Mehran, Gennaro Giustino, Ajay J Kirtane, Patrick W Serruys, Gary S Mintz, Gregg W Stone
OBJECTIVES: The aim of this study was to investigate the impact of pre-diabetes (pre-DM) on coronary plaque characteristics and ischemic outcomes in patients with acute coronary syndromes (ACS). BACKGROUND: Pre-DM (i.e., the early stages of glucometabolic disturbance) is common among patients with ACS, but the extent to which pre-DM influences coronary plaque characteristics and the risk for adverse ischemic events is unclear. METHODS: In the PROSPECT (Providing Regional Observations to Study Predictors of Events in Coronary Tree) study, patients with ACS underwent quantitative coronary angiography, grayscale intravascular ultrasound, and radiofrequency intravascular ultrasound after successful percutaneous coronary intervention...
October 14, 2017: JACC. Cardiovascular Imaging
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