Sindhu Pandurangi, Reena Mourya, Shreya Nalluri, Lin Fei, Shun Dong, Sanjiv Harpavat, Stephen L Guthery, Jean P Molleston, Philip Rosenthal, Ronald J Sokol, Kasper S Wang, Vicky Ng, Estella M Alonso, Evelyn K Hsu, Saul J Karpen, Kathleen M Loomes, John C Magee, Benjamin L Shneider, Simon P Horslen, Jeffrey H Teckman, Jorge A Bezerra
BACKGROUND AIMS: High levels of serum matrix metalloproteinase-7 (MMP-7) have been linked to biliary atresia (BA), with wide variation in concentration cutoffs. We investigated accuracy of serum MMP-7 as a diagnostic biomarker in a large North American cohort. APPROACH RESULTS: MMP-7 was measured in serum samples of 399 cholestatic infants in the Prospective Database of Infants with Cholestasis study of the Childhood Liver Disease Research Network, 201 infants with BA and 198 with non-BA cholestasis (age median: 64 and 59 days, p=0...
March 6, 2024: Hepatology: Official Journal of the American Association for the Study of Liver Diseases