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Interleukin 35

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https://www.readbyqxmd.com/read/29151411/-protective-effect-of-thalidomide-on-ali-induced-by-paraquat-poisoning-in-rats-and-its-mechanism
#1
Tao Liu, Yuan Xie, Mengtong Xu, Fenshuang Zheng
OBJECTIVE: To investigate the protective effect of thalidomide on acute lung injury (ALI) induced by paraquat (PQ) poisoning in rats and its possible mechanism. METHODS: Sixty SPF Wistar rats were randomly divided into six groups with 10 rats in each group. The rat model of PQ poisoning was reproduced by intraperitoneal injection of PQ solution 20 mg/kg (PQ model group), and the rats were treated by intraperitoneal injection of gradient thalidomide (50, 100, 200 mg/kg treatment groups) 30 minutes later continuously for 3 days...
November 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29151409/-curative-effect-of-paraquat-detoxification-recipe-combined-with-continuous-hemoperfusion-in-the-treatment-of-patients-with-app-and-clinical-value-of-presepsin
#2
Weizhan Wang, Jing Li, Baoyue Zhu, Xun Gao, Qingmian Xiao, Hongna Qi, Yanqiao Ye, Yongjian Liu, Yongyan Han, Gongying Ma, Pu Wang
OBJECTIVE: To investigate the clinical effect of paraquat (PQ) detoxification recipe combined with continuous hemoperfusion (HP) in the treatment of patients with acute paraquat poisoning (APP) and clinical significance of soluble CD14 subtype (sCD14-st, Presepsin). METHODS: A prospective randomized controlled trial was conducted. 152 patients with moderate APP admitted to Department of Emergency Medicine of Harrison International Peace Hospital Affiliated to Hebei Medical University from July 2013 to June 2017 were enrolled, and they were randomly divided into three groups...
November 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29150266/interleukin-35-and-hepatocyte-growth-factor-as-a-novel-combined-immune-gene-therapy-for-multiple-sclerosis-disease
#3
Samira Moghadam, Maryam Erfanmanesh, Abdolreza Esmaeilzadeh
An autoimmune demyelination disease of the Central Nervous System, Multiple Sclerosis, is a chronic inflammation which mostly involves young adults. Suffering people face functional loss with a severe pain. Most current MS treatments are focused on the immune response suppression. Approved drugs suppress the inflammatory process, but factually, there is no definite cure for Multiple Sclerosis. Recently developed knowledge has demonstrated that gene and cell therapy as a hopeful approach in tissue regeneration...
November 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29149541/diagnostic-accuracy-of-serum-mir-122-and-mir-199a-in-women-with-endometriosis
#4
Ahmed M Maged, Wesam S Deeb, Azza El Amir, Sherif S Zaki, Heba El Sawah, Maged Al Mohamady, Ahmed A Metwally, Maha A Katta
OBJECTIVE: To evaluate the value of serum microRNA-122 (miR-122) and miR-199a as reliable noninvasive biomarkers in the diagnosis of endometriosis. METHODS: During 2015-2016, at a teaching hospital in Egypt, a prospective cohort study was conducted on 45 women with pelvic endometriosis and 35 women who underwent laparoscopy for pelvic pain but were not diagnosed with endometriosis. Blood and peritoneal fluid (PF) samples were collected; interleukin-6 (IL-6) was detected by enzyme-linked immunosorbent assay and miR-122 and miR-199a expression was measured by quantitative real-time polymerase chain reaction...
November 17, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29141218/reciprocal-expression-of-il-35-and-il-10-defines-two-distinct-effector-treg-subsets-that-are-required-for-maintenance-of-immune-tolerance
#5
Xundong Wei, Jianhua Zhang, Qianchong Gu, Man Huang, Wei Zhang, Jie Guo, Xuyu Zhou
Regulatory T cells (Tregs) can exert their functions through multiple suppressive mechanisms; however, it is unclear how Tregs exactly employ these mechanisms. In this study, we found that interleukin-35 (IL-35)-producing Tregs were a distinct effector population from the IL-10-producing subset. We also revealed that these two subsets of effector Tregs have different transcription factor dependency. Terminal differentiation regulator Blimp1 was only critical for IL-10 production, but not for IL-35; Foxp3 was essential for IL-35 but dispensable for IL-10 production...
November 14, 2017: Cell Reports
https://www.readbyqxmd.com/read/29131072/il-21-is-increased-in-nasal-polyposis-and-after-stimulation-with-staphylococcus-aureus-enterotoxin-b
#6
Lien Calus, Lara Derycke, Melissa Dullaers, Thibaut Van Zele, Natalie De Ruyck, Claudina Pérez-Novo, Gabriele Holtappels, Geert De Vos, Bart N Lambrecht, Claus Bachert, Philippe Gevaert
BACKGROUND: Chronic rhinosinusitis with nasal polyposis (CRSwNP) is an inflammatory disease associated with lymphoid aggregates and local IgE production related to Staphylococcus aureus enterotoxins. T-follicular helper cells and their effector cytokine interleukin (IL)-21 play an important role in germinal center proliferation. METHODS: IL-21 was determined on the mRNA level by qPCR in nasal tissue of 3 groups of patients: control (n = 17), chronic rhinosinusitis without nasal polyposis (CRSsNP; n = 23), and CRSwNP (n = 35)...
November 9, 2017: International Archives of Allergy and Immunology
https://www.readbyqxmd.com/read/29115461/histone-deacetylase-inhibition-of-cardiac-autophagy-in-rats-on-a-high%C3%A2-fat-diet-with-low%C3%A2-dose-streptozotocin-induced-type-2-diabetes-mellitus
#7
Ting-I Lee, Kuan-Jen Bai, Yao-Chang Chen, Ting-Wei Lee, Cheng-Chih Chung, Wen-Chih Tsai, Shin-Yi Tsao, Yu-Hsun Kao
Autophagy serves a role in preserving cellular homeostasis. Diabetes mellitus (DM) impairs cardiac autophagy and is associated with an accumulation of cytotoxic proteins that may provoke apoptosis and damage cardiomyocytes. Histone deacetylase (HDAC) inhibitors attenuate cardiac fibrosis and inflammation, and improve cardiomyopathy resulting from DM. However, the effect of HDAC inhibition on autophagy in DM cardiomyopathy has not been investigated. The purpose of the present study was to evaluate whether HDAC inhibition modulates cardiac autophagy and to investigate the potential mechanisms in type 2 DM (T2DM) hearts...
October 26, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29108872/corrigendum-to-the-possible-role-of-interleukin-35-and-its-therapeutic-potential-in-pemphigus-int-immunol-42-2017-11-17
#8
Soheil Tavakolpour, Forough Kheiry, Hajar SadatMirsafaei, Meisam Akhlaghdoust
No abstract text is available yet for this article.
November 3, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29102802/psychosocial-stress-sensitizes-neuroendocrine-and-inflammatory-responses-to-escherichia-coli-challenge-in-domestic-piglets
#9
Margret Tuchscherer, Birger Puppe, Armin Tuchscherer, Ellen Kanitz
Exposure to psychosocial stress can have a profound impact on immune reactivity and health mediated by hypothalamic-pituitary-adrenal (HPA) axis activation. However, current knowledge regarding the mechanisms involved in cross-sensitization between stress and the immune system is limited. Here, we investigated the effects of a single social isolation followed by repeated oral Escherichia coli (E. coli) applications on cortisol, tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), haptoglobin and C-reactive protein (CRP) concentrations in the blood; on clinical signs of disease; and on mRNA expression of the glucocorticoid receptor (GR), mineralocorticoid receptor (MR), 11β-hydroxysteroid dehydrogenase 1 and 2 (11β-HSD1 and 11β-HSD2), TNF-α and IL-6 in the hypothalamus, prefrontal cortex (PFC) and spleen of 7-, 21- and 35-day-old piglets...
November 1, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29098839/-systematic-review-of-chuankezhi-injection-for-treating-acute-exacerbation-of-chronic-obstructive-pulmonary-disease
#10
Shi-Qi Chen, Xin-Yu Yang, Xiao-Yi Tang, Min Li, Shuo Liu, Jing Liang, Xiao-Yu Zhang, Hong-Cai Shang
To evaluate the inflammatory factors, the pulmonary function, the efficiency and the safety of Chuankezhi injection for treating acute exacerbation of chronic obstructive pulmonary disease (AECOPD). The randomized controlled trials (RCTs) on Chuankezhi injection for treating AECOPD were collected from 7 databases (PubMed, CNKI, et al) between inception to November 2016. Two reviewers independently screened literature and extracted the data according to the inclusion and exclusion criteria, and assessed methodological quality of included studies according to the criteria from Cochrane Reviewer's Handbook 5...
July 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29094224/primary-metastatic-osteosarcoma-results-of-a-prospective-study-in-children-given-chemotherapy-and-interleukin-2
#11
Cristina Meazza, Graziella Cefalo, Maura Massimino, Primo Daolio, Ugo Pastorino, Paolo Scanagatta, Carlo Morosi, Marta Podda, Andrea Ferrari, Monica Terenziani, Filippo Spreafico, Michela Casanova, Antonina Parafioriti, Paola Collini, Lorenza Gandola, Stefano Bastoni, Veronica Biassoni, Elisabetta Schiavello, Stefano Chiaravalli, Nadia Puma, Luca Bergamaschi, Roberto Luksch
To improve the poor prognosis for children with metastatic osteosarcoma (OS), interleukin-2 (IL-2) was added to the standard treatment due to its capacity to activate lymphocytes and differentiate lymphocyte subsets into lymphokine-activated killer (LAK) cells that are capable of recognizing and killing various tumor cells. This study concerns a cohort of unselected patients aged < 18 years with metastatic OS, who were treated with IL-2, high-dose methotrexate, doxorubicin, cisplatin, ifosfamide, LAK reinfusion, and surgery, between 1995 and 2010...
November 1, 2017: Medical Oncology
https://www.readbyqxmd.com/read/29094018/comparison-of-nasal-cytokine-profiles-of-human-metapneumovirus-and-respiratory-syncytial-virus
#12
Jin-Sung Park, Young-Ho Kim, Eunmi Kwon, Zak Callaway, Takao Fujisawa, Chang-Keun Kim
Background: Human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) share some epidemiological and clinical characteristics; however, few studies have examined the mechanisms by which these viruses induce airway inflammation. Objective: This study was undertaken to compare cytokine profiles in hMPV and RSV patients to investigate possible differences in inflammatory pathways. Methods: Nasopharyngeal aspirate specimens were collected from 1,008 pediatric patients hospitalized for acute lower respiratory tract infection with wheezing and 20 normal healthy controls...
October 2017: Asia Pacific Allergy
https://www.readbyqxmd.com/read/29091301/il-6-promoter-polymorphism-increased-risks-of-recurrent-stroke-in-the-young-patients-with-moderate-internal-carotid-artery-stenosis
#13
Ou Minghui, Cuiping Yao, Xiaoping Ma, Xiangluan Xing, Wenting He, Huanmin Gao
Interleukin-6 (IL-6) is a pleiotropic cytokine with both pro-inflammatory and anti-inflammatory properties. Increased serum IL-6 is associated with higher risk of cerebral vascular diseases, however, the circulating levels of IL-6 vary greatly between individuals for bioenvironmental or genetic interferes by IL-6 transcription therefore this study was to investigate if IL-6 promoter polymorphisms predict the recurrence of young stroke. 94 patients with moderate internal carotid artery stenosis and 94 healthy subjects were selected...
November 1, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29074035/the-il-12-cytokine-family-in-cardiovascular-diseases
#14
T van der Heijden, I Bot, J Kuiper
Cytokines of the Interleukin (IL)-12 family, consisting of IL-12, IL-23, IL-27 and IL-35, are important regulators in (chronic) inflammatory disorders such as rheumatoid arthritis and multiple sclerosis, but also in cardiovascular diseases. Cytokines of the IL-12 family consist of two subunits and are known for their regulatory functions in the immunologic response, more specifically in the regulation and differentiation of T-helper (Th) cells such as Th1 and Th17 cells. Binding of these cytokines to its specific heterodimeric receptor results in the activation of the JAK-STAT signaling...
October 23, 2017: Cytokine
https://www.readbyqxmd.com/read/29069729/interleukin-35-expression-is-associated-with-colon-cancer-progression
#15
Jian Zhang, Tao Mao, Shuyun Wang, Dongsheng Wang, Zhaojian Niu, Zhenqing Sun, Jianli Zhang
Colon cancer development is closely related to inflammation. Thus, we conducted the present investigation to study the effects of IL-35 (Interleukin 35), a newly identified anti-inflammatory factor, on colon cancer development. We first evaluated the IL-35 expression in 186 pairs of colon cancer samples and paired adjacent normal tissues by qPCR, ELISA (Enzyme-linked immunoassay) and tissue microarrays. Then the role of IL-35 on patient survival rates, colon cancer progression and their sensitivity to chemotherapy drugs were assessed...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/29068992/plasma-interleukin-27-levels-in-patients-with-coronary-artery-disease
#16
Kotaro Miura, Emi Saita, Norie Suzuki-Sugihara, Koutaro Miyata, Nobuhiro Ikemura, Reiko Ohmori, Yukinori Ikegami, Yoshimi Kishimoto, Kazuo Kondo, Yukihiko Momiyama
Interleukin (IL)-27, one of cytokines in the IL-12 family, is considered to have both pro- and anti-inflammatory properties. However, blood IL-27 levels in coronary artery disease (CAD) have not been fully elucidated yet. This cross-sectional study was done to elucidate the association between blood IL-27 levels and CAD.We investigated plasma IL-27 and high-sensitivity C-reactive protein (hsCRP) levels in 274 consecutive patients who underwent elective coronary angiography for suspected CAD. CAD was present in 177 patients [30 acute coronary syndrome (ACS) and 147 stable CAD]...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29059196/exogenous-dietary-lysozyme-improves-the-growth-performance-and-gut-microbiota-in-broiler-chickens-targeting-the-antioxidant-and-non-specific-immunity-mrna-expression
#17
Mervat A Abdel-Latif, Ali H El-Far, Ahmed R Elbestawy, Rania Ghanem, Shaker A Mousa, Hatem S Abd El-Hamid
Supplementation of exogenous enzymes in chickens has been widely practiced, yet mechanisms responsible are not fully delineated. To investigate the effects of the dietary lysozyme on the growth performance and immunity of broiler chickens, a total of 120 one-day-old Ross 308 chicks were randomly allocated into four groups, each having three replicates (30 birds/group). The chicks were fed the starter (1-21 d) and grower (22-35 d) diets supplemented with 0 (control), 70 (LYZ70), 90 (LYZ90) and 120 (LYZ120) g of lysozyme 10%® per ton of basal diet for five weeks...
2017: PloS One
https://www.readbyqxmd.com/read/29055471/consistent-efficacy-of-daclizumab-beta-across-patient-demographic-and-disease-activity-subgroups-in-patients-with-relapsing-remitting-multiple-sclerosis
#18
John W Rose, Gavin Giovannoni, Heinz Wiendl, Ralf Gold, Eva Havrdová, Ludwig Kappos, Krzysztof W Selmaj, Jun Zhao, Katherine Riester, L Claire Tsao, Steven J Greenberg
BACKGROUND: Daclizumab beta is a humanized monoclonal antibody specific for the human interleukin-2 receptor alpha chain (CD25). In two pivotal studies in relapsing multiple sclerosis (MS), patients treated with daclizumab beta exhibited lower annualized relapse rates (ARR) when compared with placebo or with intramuscular (IM) interferon beta-1a. OBJECTIVES: To determine if the efficacy of daclizumab beta demonstrated in the phase 2 SELECT study and the phase 3 DECIDE study was consistent in patient subgroups...
October 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29054137/il-35-gene-modified-mesenchymal-stem-cells-protect-the-con-a-induced-fulminant-hepatitis-through-decreasing-the-ifn-g-level
#19
Wei Wang, Hao Guo, Hongyue Li, Yongjia Yan, Chao Wu, Xiaodong Wang, Xianghui He, Na Zhao
Interleukin 35 (IL-35) is a relatively newly identified cytokine required for the regulatory and suppressive functions of regulatory T cells(Treg), playing an important role in the prevention of autoimmune diseases. In this study, we used the MSCs as the gene-delivery vehicles for IL-35 gene therapy and investigated their protective effects in Con A-induced autoimmune hepatitis. Results showed that IL-35 gene modified MSCs(IL-35-MSCs) can specifically migrate to the injured liver tissues and significantly narrow the necrosis areas and reduce the hepatocytes apoptosis...
October 20, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/29050115/-effects-of-ovalbumin-exposure-during-pregnancy-of-mice-on-the-ovalbumin-re-exposure-in-adult-progeny
#20
Z Song, H Q Li
Objective: To observe the immunoreaction of offspring mice by ovalbumin (OVA) re-exposure after their mothers exposed to OVA during pregnancy. Method: A prospective controlled study was conducted to observe mice after repeated OVA exposures at 6-8 weeks.Their mothers were exposed to OVA during different stages of pregnancy.The symptoms were recorded and scored.The levels of OVA-specific IgE in serum, interferon-γ(IFN-γ) and interleukin-4(IL-4) in supernatant of spleen primary lymphocytes in vitro were measured by ELISA...
October 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
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