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https://www.readbyqxmd.com/read/27921246/investigation-of-selenium-pretreatment-in-the-attenuation-of-lung-injury-in-rats-induced-by-fine-particulate-matters
#1
Jie Liu, Yingying Yang, Xuejiao Zeng, Liang Bo, Shuo Jiang, Xihao Du, Yuquan Xie, Rongfang Jiang, Jinzhuo Zhao, Weimin Song
Selenium (Se) is vital for health because of its antioxidative and anti-inflammation functions. The aim of this study was to determine if dietary selenium could inhibit the rat lung injury induced by ambient fine particulate matter (PM2.5). Sprague-Dawley rats were randomly allocated in seven groups (n = 8). The rats in PM2.5 exposure group were intratracheally instilled with 40 mg/kg of body weight (b.w.) of PM2.5 suspension. The rats in Se prevention groups were pretreated with 17.5, 35, or 70 μg/kg b...
December 5, 2016: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/27917205/impact-of-weight-loss-on-oxidative-stress-and-inflammatory-cytokines-in-obese-type-2-diabetic-patients
#2
Shehab M Abd El-Kader, Mohammed H Saiem Al-Dahr
BACKGROUND: Type 2 diabetes mellitus is associated with abnormal markers of inflammatory cytokines and oxidative stress markers. Although, these abnormalities could be modulated with weight reduction; there is limitation in clinical studies that have addressed the beneficial effects of weight reduction in modulating biomarkers of inflammatory cytokines and oxidative stress for obesity associated with type 2 diabetes mellitus. OBJECTIVE: This study was designed to detect the effects of weight loss on the inflammatory cytokines, oxidative stress markers in obese type 2 diabetic patients...
September 2016: African Health Sciences
https://www.readbyqxmd.com/read/27916626/impact-of-sequencing-targeted-therapies-with-high-dose-interleukin-2-immunotherapy-an-analysis-of-outcome-and-survival-of-patients-with-metastatic-renal-cell-carcinoma-from-an-on-going-observational-il-2-clinical-trial-proclaim-sm
#3
Joseph I Clark, Michael K K Wong, Howard L Kaufman, Gregory A Daniels, Michael A Morse, David F McDermott, Sanjiv S Agarwala, Lionel D Lewis, John H Stewart, Ulka Vaishampayan, Brendan Curti, René Gonzalez, Jose Lutzky, Venkatesh Rudraptna, Lee D Cranmer, Joanne M Jeter, Ralph J Hauke, Gerald Miletello, Mohammed M Milhem, Asim Amin, John M Richart, Mayer Fishman, Sigrun Hallmeyer, Sapna P Patel, Peter Van Veldhuizen, Neeraj Agarwal, Bret Taback, Jonathan S Treisman, Marc S Ernstoff, Jessica C Perritt, Hong Hua, Tharak B Rao, Janice P Dutcher, Sandra Aung
BACKGROUND: This analysis describes the outcome for patients who received targeted therapy (TT) prior to or following high-dose interleukin-2 (HD IL-2). PATIENTS AND METHODS: Patients with renal cell carcinoma (n = 352) receiving HD IL-2 were enrolled in Proleukin(R) Observational Study to Evaluate the Treatment Patterns and Clinical Response in Malignancy (PROCLAIM(SM)) beginning in 2011. Statistical analyses were performed using datasets as of September 24, 2015...
October 29, 2016: Clinical Genitourinary Cancer
https://www.readbyqxmd.com/read/27916086/-recombinant-adenovirus-type-5-does-not-aggravate-asthma-symptoms-in-a-mouse-model-of-ovalbumin-induced-asthma
#4
Zhengling Zhang, Yiling Zhang, Jing Han, Ping Lu, Lin Xu
Objective To explore the effect of recombinant adenovirus type 5 (rAd5) on a mouse model of ovalbumin (OVA)-induced asthma. Methods Sixty female C57BL/6 mice (6-8 weeks old and 18-20 g) were randomly divided into 4 groups: healthy control group, rAd5 control group, OVA asthma control group and OVA asthma group with rAd5 immunization. 15 mice in each group. The mice in the OVA asthma control group and the OVA asthma group with rAd5 immunization were sensitized by intraperitoneal injection of 50 μg OVA emulsified in 2 mg of aluminum potassium sulfate on day 0, 7 and 14; subsequently, the mice in the two groups were exposed to OVA aerosol challenge for 3 consecutive days (on day 42, 43 and 44)...
December 2016: Xi Bao Yu Fen Zi Mian Yi Xue za Zhi, Chinese Journal of Cellular and Molecular Immunology
https://www.readbyqxmd.com/read/27916033/-the-early-changes-of-respiratory-system-resistance-and-%C3%AE-%C3%AE-t-lymphocytes-infiltrated-in-graft-after-lung-transplantation-of-mouse
#5
Q R Chen, L F Wang, Y M Zhang, J N Xu, H Li, Y Z Ding
Objectives: To generate an orthotopic left lung transplantation model in mice, and to observe the early changes of respiratory system resistance and γδT lymphocytes infiltrated in grafts. Methods: The research time was from March 2014 to May 2015. The male C57BL/6 mice (n=35) and BALB/c mice (syngenic group, n=10) were randomly divided into five groups. Control group (n=5): wild C57BL/6 mice; syngenic transplant group (n=10): C57BL/6→C57BL/6; allogenic transplant group(allogenic group, n=10): BALB/c→C57BL/6; each transplant group was randomly divided into 3-day and 7-day subgroups (n=5)...
December 1, 2016: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/27913992/c-type-natriuretic-peptide-prevents-kidney-injury-and-attenuates-oxidative-and-inflammatory-responses-in-hemorrhagic-shock
#6
Gan Chen, Xiang Song, Yujing Yin, Sha Xia, Qingjun Liu, Guoxing You, Lian Zhao, Hong Zhou
Oxidative stress induced by hemorrhagic shock (HS) initiates a systemic inflammatory response, which leads to subsequent kidney injury. This study assessed the efficacy of c-type natriuretic peptide (CNP) in attenuating kidney injury in a rat model of hemorrhagic shock and resuscitation (HS/R). Sodium pentobarbital-anesthetized adult male Wistar rats underwent HS induced by the withdrawal of blood to a mean arterial pressure of 30-35 mmHg for 50 min. Then, the animals received CNP (25 μg/kg) or vehicle (saline) intravenously, followed byresuscitation with 1...
December 2, 2016: Amino Acids
https://www.readbyqxmd.com/read/27909869/effect-of-oral-%C3%AF-3-polyunsaturated-fatty-acids-as-a-complement-management-to-control-fistula-output-and-inflammation-in-patients-with-digestive-fistula
#7
José Luis Martínez-Ordaz, Ilka Boscó-Gárate, Arturo Cérbulo-Vázquez, Lourdes Arriaga-Pizano, Isabel Wong-Baeza, Patricio Sánchez-Fernandez, Constantino López-Macías, Armando Isibasi, Eduardo Ferat-Osorio
BACKGROUND: The presence of digestive fistula involves chronic inflammation and fibrosis. It has been reported that ω3-polyunsaturated fatty acids stimulate the resolution of inflammation. AIM: Determine if the administration of oral ω3 reduces fistula output and the time required for fistula closure. METHODS: Forty-nine patients with postoperative fistula were randomly divided in two groups: 26 received conventional treatment and 23 received the conventional treatment supplemented with ω3 (540 mg eicosapentaenoic acid and 360 mg docosahexaenoic acid) for 35 days...
December 1, 2016: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/27906187/systemic-application-of-3-methyladenine-markedly-inhibited-atherosclerotic-lesion-in-apoe-mice-by-modulating-autophagy-foam-cell-formation-and-immune-negative-molecules
#8
Shen Dai, Bo Wang, Wen Li, Liyang Wang, Xingguo Song, Chun Guo, Yulan Li, Fengming Liu, Faliang Zhu, Qun Wang, Xiaoyan Wang, Yongyu Shi, Jianing Wang, Wei Zhao, Lining Zhang
A growing body of evidence demonstrates that autophagy, an evolutionarily conserved intracellular degradation process, is involved in the pathogenesis of atherosclerosis and has become a potential therapeutic target. Here we tested the effect of two inhibitors of phosphatidylinositol 3-kinase, 3-methyladenine (3-MA) and 2-(4-morpholinyl)-8-phenyl-chromone (LY294002), commonly used as inhibitors of autophagy, in atherosclerosis in apolipoprotein E(-/-) mice. Systemic application of 3-MA but not LY294002 markedly reduced the size of atherosclerotic plaque and increased the stability of lesions in high-fat diet-fed mice as compared with controls...
December 1, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/27903591/platelet-rich-plasma-powder-a-new-preparation-method-for-the-standardization-of-growth-factor-concentrations
#9
Matthias Kieb, Frank Sander, Cornelia Prinz, Stefanie Adam, Anett Mau-Möller, Rainer Bader, Kirsten Peters, Thomas Tischer
BACKGROUND: Platelet-rich plasma (PRP) is widely used in sports medicine. Available PRP preparations differ in white blood cell, platelet, and growth factor concentrations, making standardized research and clinical application challenging. PURPOSE: To characterize a newly standardized procedure for pooled PRP that provides defined growth factor concentrations. STUDY DESIGN: Controlled laboratory study. METHODS: A standardized growth factor preparation (lyophilized PRP powder) was prepared using 12 pooled platelet concentrates (PCs) derived from different donors via apheresis...
November 30, 2016: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/27890374/clinical-significance-of-dynamic-detection-for-serum-levels-of-mcp-1-tnf-%C3%AE-and-il-8-in-patients-with-acute-pancreatitis
#10
Yuan-Zheng Yang, Ying Xiang, Mian Chen, Li-Na Xian, Xiao-Yan Deng
OBJECTIVE: To observe dynamic changes of levels of monocyte chemotactic protein-1 (MCP-1), tumor necrosis factor-α (TNF-α) and interleukin-8 (IL-8) in patients with acute pancreatitis and to investigate its evaluation value on the severity of acute pancreatitis. METHODS: A total of 109 patients with acute pancreatitis admitted were divided into mild acute pancreatitis group (MAP group, 42 cases), moderately severe acute pancreatitis (MSAP group, 35 cases) and severe acute pancreatitis (SAP group, 32 cases)...
November 2016: Asian Pacific Journal of Tropical Medicine
https://www.readbyqxmd.com/read/27885532/whey-protein-supplementation-enhances-body-fat-and-weight-loss-in-women-long-after-bariatric-surgery-a-randomized-controlled-trial
#11
Daniela Lopes Gomes, Milene Moehlecke, Fernanda Bassan Lopes da Silva, Eliane Said Dutra, Beatriz D'Agord Schaan, Kenia Mara Baiocchi de Carvalho
BACKGROUND: The ideal nutritional approach for weight regain after bariatric surgery remains unclear. OBJECTIVE: The objective of this study is to assess the effect of whey protein supplementation on weight loss and body composition of women who regained weight 24 or more months after bariatric surgery. METHODS: This is a 16-week open-label, parallel-group, randomized controlled trial of women who regained at least 5 % of their lowest postoperative weight after a Roux-en-Y gastric bypass (RYGB)...
November 24, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27882147/molecular-profiling-of-a-simple-rat-model-of-open-tibial-fractures-with-hematoma-and-periosteum-disruption
#12
Jose Rafael Villafan-Bernal, Lorenzo Franco-De La Torre, Ana Soledad Sandoval-Rodriguez, Juan Armendariz-Borunda, Juan Luis Alcala-Zermeno, Jose Alfonso Cruz-Ramos, Gabriela Lopez-Armas, Blanca Estela Ramirez-Bastidas, Gracia Viviana González-Enríquez, Emerson Armando Collazo-Guzman, Raigam Jafet Martinez-Portilla, Sergio Sánchez-Enríquez
Bone fractures are a worldwide public health concern. Therefore, improving understanding of the bone healing process at a molecular level, which could lead to the discovery of potential therapeutic targets, is important. In the present study, a model of open tibial fractures with hematoma disruption, periosteal rupture and internal fixation in 6-month-old male Wistar rats was established, in order to identify expression patterns of key genes and their protein products throughout the bone healing process. A tibial shaft fracture was produced using the three-point bending technique, the hematoma was drained through a 4-mm incision on the medial aspect of the tibia and the fracture stabilized by inserting a needle into the medullary canal...
November 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27878686/role-of-anti-inflammatory-cytokines-il-35-and-il-37-in-asthma
#13
REVIEW
Daiju Hu
Asthma is a chronic airway inflammation that is characterized by intense eosinophil infiltrates, mucus hypersecretion, airway remodeling, and airway hyperresponsiveness. Interleukin (IL)-35 and IL-37 are two cytokines with anti-inflammatory effects found in immune response. Recent findings suggested that expressions of IL-35 and IL-37 are abnormal in asthma. Functional analysis further confirmed the important roles of them in the pathogenesis of asthma. The present study reviewed the updated evidence indicating the roles of IL-35 and IL-37 in asthma...
November 23, 2016: Inflammation
https://www.readbyqxmd.com/read/27878431/aqueous-immune-mediators-in-malignant-uveal-melanomas-in-comparison-to-benign-pigmented-intraocular-tumors
#14
Yoshihiko Usui, Kinya Tsubota, Tsuyoshi Agawa, Shunichiro Ueda, Kazuhiko Umazume, Yoko Okunuki, Takeshi Kezuka, Naoyuki Yamakawa, Hiroshi Goto
BACKGROUND: To examine the usefulness of measuring immune mediators in aqueous humor samples for differentiating malignant uveal melanoma from benign pigmented intraocular tumors. METHODS: Thirteen eyes of 13 patients with uveal melanoma were studied, and 13 eyes of 13 patients with benign pigmented intraocular tumors served as controls. Undiluted samples of aqueous humor were collected, and a cytometric bead array was used to determine the aqueous humor concentrations of 35 immune mediators comprising 14 interleukins (IL), interferon-γ, interferon-γ-inducible protein-10, monocyte chemoattractant protein (MCP)-1, macrophage inflammatory protein (MIP)-1α, MIP-1β, regulated on activation normal T cell expressed and secreted, monokine induced by interferon-γ, basic fibroblast growth factor, Fas ligand, granzyme A, granzyme B, eotaxin, interferon-inducible T-cell alpha chemoattractant, fractalkine, granulocyte macrophage colony-stimulating factor, granulocyte colony-stimulating factor, vascular endothelial growth factor, angiogenin, tumor necrosis factor-α, lymphotoxin-α, and CD40L...
November 22, 2016: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/27867385/expanding-diversity-in-molecular-structures-and-functions-of-the-il-6-il-12-heterodimeric-cytokine-family
#15
REVIEW
Hideaki Hasegawa, Izuru Mizoguchi, Yukino Chiba, Mio Ohashi, Mingli Xu, Takayuki Yoshimoto
The interleukin (IL)-6/IL-12 family cytokines have pleiotropic functions and play critical roles in multiple immune responses. This cytokine family has very unique characteristics in that they comprise two distinct subunits forming a heterodimer and each cytokine and receptor subunit shares with each other. The members of this cytokine family are increasing; currently, there are more than six cytokines, including the tentatively named cytokines IL-Y (p28/p40), IL-12 (p35/p40), IL-23 (p19/p40), IL-27 [p28/Epstein-Barr virus-induced protein 3 (EBI3)], IL-35 (p35/EBI3), and IL-39 (p19/EBI3)...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27861424/experimental-and-clinical-evaluation-of-pre-dilution-and-post-dilution-continuous-veno-venous-hemofiltration-on-clearance-characteristics
#16
Shinya Chihara, Yoshiki Masuda, Michiaki Yamakage
We compared the clearance characteristics of low to high molecular weight substances during pre- and post-dilution continuous veno-venous hemofiltration (CVVH) in experimental and clinical conditions.Experimental circuits for pre- and post-dilution CVVH were prepared using a test solution containing creatinine (110 Da), inulin (5,000 Da), interleukin (IL)-8 (8,000 Da), IL-6 (22,000 Da), and tumor necrosis factor (TNF)-α (51,000 Da). Quantity of test solution flow and filtration flow (QF) were set to 150 ml/min and 10, 20, and 35 ml/min, respectively...
November 16, 2016: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/27855302/the-possible-role-of-interleukin-35-and-its-therapeutic-potential-in-pemphigus
#17
REVIEW
Soheil Tavakolpour, Forough Kheiry, Hajar Sadat Mirsafaei, Meisam Akhlaghdoust
Pemphigus is an autoimmune disease that causes blistering and is life-threatening if left untreated. Nowadays, finding a promising treatment for pemphigus remains a serious challenge. Various treatments are currently recommended to treat this disease, but they rarely lead to complete and durable remission. Regulatory cells appear to have a critical role in numerous autoimmune diseases, so it is possible that promotion of these cells may induce remission. This study presents a new approach to treating pemphigus that has not been discussed to date...
November 14, 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27836181/circadian-preferences-oxidative-stress-and-inflammatory-cytokines-in-bipolar-disorder-a-community-study
#18
Thaise Campos Mondin, Taiane de Azevedo Cardoso, Fernada Pedrotti Moreira, Carolina Wiener, Jean Pierre Oses, Luciano Dias de Mattos Souza, Karen Jansen, Pedro Vieira da Silva Magalhães, Flávio Kapczinski, Ricardo Azevedo da Silva
OBJECTIVE: To assess circadian preference among a community sample of people with bipolar disorder, major depression and without any mood disorders. Secondly, we investigated the association of circadian preference with cytokines interleukin-6 (IL-6), interleukin-10 (IL-10) and, tumor necrosis factor alpha (TNF-α) and oxidative stress assessed by thiobarbituric acid reactive substances (TBARS), uric acid and Protein Carbonyl Content (PCC). METHOD: A cross-sectional study nested in a population-based sample...
November 4, 2016: Journal of Neuroimmunology
https://www.readbyqxmd.com/read/27833443/urine-interleukin-6-interleukin-8-and-transforming-growth-factor-%C3%AE-1-in-infants-with-urinary-tract-infection-and-asymptomatic-bacteriuria
#19
Grażyna Krzemień, Agnieszka Szmigielska, Agnieszka Turczyn, Małgorzata Pańczyk-Tomaszewska
INTRODUCTION: Urinary tract infection (UTI) occurs in 1.1% of girls and 1.4% of boys during the first year of life. Asymptomatic bacteriuria (ABU) is usually detected incidentally in 0.9% of girls and 2.5% of boys at this age. The aim of the study was to assess the usefulness of measurement of pro-inflammatory urine interleukin (IL)-6 and IL-8 concentrations and anti-inflammatory transforming growth factor β1 (TGF-β1) level in infants with febrile UTI, non-febrile UTI and ABU. MATERIAL AND METHODS: A total of 35 children, mean age 6...
2016: Central-European Journal of Immunology
https://www.readbyqxmd.com/read/27824861/identification-of-biomarkers-of-impaired-sensory-profiles-among-autistic-patients
#20
Afaf El-Ansary, Wail M Hassan, Hanan Qasem, Undurti N Das
BACKGROUND: Autism is a neurodevelopmental disorder that displays significant heterogeneity. Comparison of subgroups within autism, and analyses of selected biomarkers as measure of the variation of the severity of autistic features such as cognitive dysfunction, social interaction impairment, and sensory abnormalities might help in understanding the pathophysiology of autism. METHODS AND PARTICIPANTS: In this study, two sets of biomarkers were selected. The first included 7, while the second included 6 biomarkers...
2016: PloS One
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