Adenocystic carcinoma

PURPOSE: To review 22 patients with globus pharyngis among a group of 39 patients who presented with burning mouth syndrome and to highlight the clinical presentation and treatment outcome of these oropharyngeal symptoms, often ignored by practicing oral surgeons. PATIENTS AND METHODS: We carried out a retrospective review of 39 patients with burning mouth syndrome seen at oral surgery units of three specialist hospitals in Enugu, Nigeria between 2001 and 2010. The focus was on the 22 of these patients with burning mouth syndrome and globus pharyngis (the persistent sensation of having phlegm, a pill or some other sort of obstruction in the throat when there is none)...

Cis-platinum (II) diammine dichloride (CDDP) is a platinum-based anticancer agent, and is often used for chemotherapy for malignant tumors, albeit CDDP has serious side-effects, including xerostomia (dry mouth). Since patients with xerostomia have reduced quality of life, it is urgent and important to identify nontoxic and natural agents capable of reducing the adverse effect of chemotherapy on salivary gland function. Therefore, we commenced an institutional collaborative project in which candidates of herbal extracts were selected from more than 400 bioactive herbal products for their potential therapeutic effects not only on xerostomia, but also on oral diseases...

The class of salivary gland tumours is very heterogenous, both in a histopathological and clinical sense. Since they are uncommon lesions, their clinical management is still problematic. Molecular mechanisms underlying the development of these cancer types may be fundamental for the diagnosis, treatment and prognosis of this disease. In this study, the gene expression of nuclear factor-kappa B (NKkB1/p65), c-Jun N-terminal kinase (JNK1) and growth arrest and DNA damage (GADD45A), which all play an important role in inflammatory and cell survival mechanisms, was assessed in benign and malignant neoplasms of the salivary gland...

BACKGROUND: Adenoid cystic carcinoma of the respiratory tract is a rare form of malignant neoplasm that arises from salivary glands. A surgical resection with or without radiotherapy is commonly recommended. For inoperable patients, radiotherapy and endobronchial treatment, which include laser and stent insertion, are important therapeutic modalities. AIM: To summarize our experience in adenocystic carcinoma of the respiratory tract. METHODS: Seven patients with adenoid cystic carcinoma were diagnosed and treated in the Pulmonary Institute at Rabin Medical Center, a tertiary care hospital in central Israel in 2000-2006...

Several breakthrough discoveries have led to substantial improvements in the quality of pulmonary medicine, as well as to new medications, techniques, and toots. This issue of "Harefuah" is dedicated to the current knowledge in pulmonary research and medicine, novel discoveries in the field, and challenges for the future. One paper adds informative data about COPD while another provides a review that summarizes the development of asthma therapy and the potential clinical use of omalizumab for the treatment of severe, allergic asthma...

BACKGROUND: The main problem of the management of suspected pleomorphic adenoma of the lacrimal gland is the safety of the preoperative diagnosis without biopsy. The current clinical standard (en bloc resection if suspected) has been questioned in this regard in recent publications. In this context we have analysed all consecutive lesions of the lacrimal gland region in our department for 5 years and evaluated pre-and intraoperative clinical and histological findings in regard to the safety of the preoperative diagnosis pleomorphic adenoma...

Cancer complicates approximately 0.1% of all pregnancies. Primary tracheal carcinoma is one of very rarely seen tumors and the rate of its being seen makes up approximately % 0.2 of all tumors of respiratory tract. The patient, 28 years old, who has 28-weeks-pregnant, was diagnosed with primary tracheal adenocystic carcinoma. Patient was made operation as thoracotomy and tracheal tumor was removed at the 28(th) week of pregnancy. Patient was delivered with sectio abdominale at the 39(th) week of pregnancy. Primary tracheal adenocystic carcinoma is very rarely seen tumors and it is the first tracheal ACC with pregnancy case in literature to have been detected and surgically treated during pregnancy...

BACKGROUND: Reconstruction of large tracheal defects has been largely unsuccessful. The purpose of this study was to review the authors' experience with microsurgical reconstruction of these defects. METHODS: Seven cases of microsurgical tracheal reconstruction were performed between May 2002 and April 2008. All but 1 patient had recurrent thyroid cancer; the other patient had primary adenocystic carcinoma of the trachea. The radial forearm free flap was used for lining in all cases...

INTRODUCTION: Adenoid cystic carcinoma (ACC) of the larynx is a rare malignancy characterized by an indolent course and late pulmonary metastases. Metastases from the larynx to the spleen are an unusual event. In the present report, we discuss a patient with adenoid cystic carcinoma of the larynx metastatic to the spleen. A review of the literature did not yield any other such incidents. We review the clinical presentation and course of adenoid cystic carcinoma, as well as the role of splenectomy for metastases...

A 50-year-old man, with a history of right lower lobectomy for pulmonary adenocystic carcinoma, presented with chronic flank pain due to a large mass in the right kidney. He also had bilateral pulmonary nodules and cardiac masses, indicating metastatic disease. Simultaneous metastatic involvement of the kidney and the heart from a rare pulmonary tumor made this case unique in the prevailing medical data.

BACKGROUND AND PURPOSE: The aim of the study was to present our results of the surgical treatment of subtemporal fossa tumours and surrounding regions using the extended subtemporal approach. MATERIAL AND METHODS: Twenty-five patients (10 women, 15 men) with subtemporal fossa tumours were included in the study. The neurological and performance status of the patients were assessed before and after surgery as well as at the conclu-sion of treatment. The approximate volume of the operated tumour, its relation to large blood vessels and cranial nerves, as well as consistency and vascularisation were assessed...

PURPOSE OF REVIEW: This article reviewed the recent developments in molecular targeted therapy in head and neck cancers. A brief summary of other pathways of interest is also enclosed. RECENT FINDINGS: The use of cetuximab in squamous cell head and neck cancer is associated with clinical benefit and, in some cases, survival. However, the use of targeted agents beyond cetuximab in this disease remains investigational. Combination therapy of molecular targeted agents with chemoradiation in the locally advanced setting of head and neck squamous cell carcinomas and nasopharyngeal cancer shows early promising results, but at the expense of increased toxicity...

BACKGROUND: Salivary glands tumors are relatively uncommon neoplasm with widely variable histopathologic and biologic characteristics. Alteration in some proto-oncogenes and tumor suppressor genes may lead to the development and progression of these tumors. AIMS: The purpose of this study was to analyze the immunohistochemical expression of P(53) and bcl-2 in some salivary gland tumors in relation to tumor size, histologic grade, and extent of invasion. SETTING AND DESIGN: The sample consisted of 22 formalin-fixed paraffin embedded blocks of benign and malignant salivary glands tumors...

4023 operations on account of primary bronchopulmonary cancer were performed in the period of 1963--2006 years. Rare malignant tumors (carcinoid, adenocystic cancer, sarcoma, large cell carcinoma etc.) were diagnosed in 379 (9,1%) cases. 275 patients of those had bronchpulmonary carcinoid; adenocystic cancer was diagnosed in 26 patients; 67 had various types of non-epithelial malignant tumors and 11 had a large cell carcinoma. All patients were operated on, morphological verification was obtained in all cases...

Activating mutations within the epidermal growth factor receptor (EGFR) identify lung adenocarcinoma patients with improved clinical responses to tyrosine kinase inhibitors gefitinib and erlotinib. By screening salivary gland carcinoma, two drug-sensitizing EGFR exon 19 delE746-A750 mutations were identified in an adenocystic and in a mucoepidermoid carcinoma of the parotid gland.

The present study was addressed to find out the expression of Bcl-2 proto-oncogene in tumor tissue derived from 24 patients with malignant oral carcinoma and oral mucosa from the same patients served as control and showed a cytoplasmic pattern of Bcl-2 immunoreactivity in basal cell layer. Fourteen of 24 (58.3%) of oral carcinoma and four adenocystic carcinoma expressed positive Bcl-2 oncogene. Well-differentiated squamous cell carcinoma showed absence of immunoreactivity. No statistically significant correlation could be demonstrated between Bcl-2 immunoreactivity and the age or sex of the patients, tumor size, and lymph node metastasis...

A variety of surgical approaches have been used in the treatment of midline cranial base tumors. These approaches usually involve complicated techniques, particularly when they are employed for tumors involving the entire clivus. This paper describes the feasibility, efficacy, and safety of the sublabial transnasal approach combined with a partial resection of the nasal floor in the treatment of midline skull base lesions. We performed this approach in three patients with midline cranial base lesions, including invasive pituitary adenoma involving the whole clivus, fibrous dysplasia, and adenocystic carcinoma...

Forty-two cases of orbital lesions in superolateral quadrant were evaluated in our study by fine needle aspiration biopsy. Cases were histologically proven wherever possible. In 92.85% cases the diseases were correctly diagnosed. Females were mainly affected. Lymphomatous tumours were diagnosed on the basis of atypical lymphoid proliferation, correlated with clinical features and findings of computed tomographic scan and managed by radiotherapy. Pseudotumours, dermoid and epithelial tumours of lacrimal gland were diagnosed accurately except in one case of malignant mixed tumour where the malignant component was aspirated...

Reported is the successful treatment of a 24-year-old male with adenocystic carcinoma involving the tracheal carina, in which the tumor extended along the right main bronchus across the orifice of the right upper lobe. The patient underwent a carinal resection plus right upper lobectomy and reconstruction of the carina, resulting in neither anastomotic complication nor recurrence of disease during 28 months of follow-up.

INTRODUCTION: Medically refractory pain related to cancer is a major indication for pain surgery. Stereotactic mesencephalic tractotomy (SMT) constitutes a widely accepted procedure in treating unilateral head and neck cancer pain. MATERIAL AND METHOD: We report a case of a MRI-based right-sided SMT for treating intractable craniofacial pain, in a 38-year-old patient, related to a previously resected adenocystic carcinoma of the parotid gland. The patient had undergone an implantation of an intrathecal morphine/clonidine pump and subsequent radiofrequency cingulotomy with only temporary improvement...