keyword
https://read.qxmd.com/read/36958992/systematic-comparisons-between-lyme-disease-and-post-treatment-lyme-disease-syndrome-in-the-u-s-with-administrative-claims-data
#21
JOURNAL ARTICLE
Ming Kei Chung, Mariaelena Caboni, Philip Strandwitz, Anthony D'Onofrio, Kim Lewis, Chirag J Patel
BACKGROUND: Post-treatment Lyme disease syndrome (PTLDS) is used to describe Lyme disease patients who have the infection cleared by antibiotic but then experienced persisting symptoms of pain, fatigue, or cognitive impairment. Currently, little is known about the cause or epidemiology of PTLDS. METHODS: We conducted a data-driven study with a large nationwide administrative dataset, which consists of more than 98 billion billing and 1.4 billion prescription records between 2008 and 2016, to identify unique aspects of PTLDS that could have diagnostic and etiologic values...
April 2023: EBioMedicine
https://read.qxmd.com/read/36951167/hospitalized-patients-with-positive-antiphospholipid-antibodies-who-have-low-complement-levels-are-at-increased-risk-for-death-a-retrospective-cohort-study
#22
JOURNAL ARTICLE
Edward Itelman, Maxim Perelman, Natali Bivar, Daniella Kent, Adva Vaisman, Gad Segal, Liat Negru, Amir Dagan
PURPOSE: To investigate whether low complement levels can predict worse outcomes in patients hospitalized with positive anti-phospholipid antibodies. METHODS: This was a retrospective cohort study. We obtained demographics, laboratory, and prognostic data of all consecutive patients hospitalized between 2007 and 2021, for whatever reason, with at least one positively abnormal anti-phospholipid antibody, who were also tested for complement levels (C3 or C4). We then compared the rates of long-term mortality, 1-year mortality, deep vein thrombosis, and pulmonary emboli between groups of low complement and normal complement levels...
March 23, 2023: Lupus
https://read.qxmd.com/read/36923755/autoimmune-polyglandular-syndrome-type-2-and-recurrent-depression
#23
Mohamed Elsayed, Eman Negm, Maximilian Gahr, Carlos Schönfeldt-Lecuona
UNLABELLED: Autoimmune polyglandular syndrome type 2 (APS-2) features autoimmune Addison's disease, autoimmune thyroid disease, and/or type 1 diabetes mellitus. Addison's disease is occasionally associated with depressive symptoms, therefore patients with APS-2 might present primarily in a psychiatric clinic. Such atypical primary presentation can possibly lead to delayed and/or inadequate diagnosis and management. CASE PRESENTATION: A 57-year-old female patient was referred to our psychiatric clinic from an internal medicine hospital presenting severe depressive symptoms...
March 2023: Annals of Medicine and Surgery
https://read.qxmd.com/read/36873640/case-report-virus-induced-hemophagocytic-lymphohistiocytosis-in-a-patient-with-apeced
#24
Oksana Boyarchuk, Olha Dyvonyak, Tetyana Hariyan, Alla Volokha
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED), also known as autoimmune polyglandular syndrome type 1 (APS-1) is a rare autosomal recessive inborn error of immunity (IEI), which is accompanied by immune dysregulation. Hypoparathyroidism, adrenocortical failure and candidiasis are its typical manifestations. Here we report about recurrent COVID-19 in a 3-year-old boy with APECED, who developed retinopathy with macular atrophy and autoimmune hepatitis after the first episode of SARS-CoV-2 infection...
2023: Frontiers in Pediatrics
https://read.qxmd.com/read/36740405/-clinical-characteristics-of-37-antiphospholipid-syndrome-patients-complicated-by-autoimmune-hemolytic-anemia
#25
JOURNAL ARTICLE
J T Zhang, W T Qi, Y Z Zhou, C Huang, J L Zhao, M T Li, X F Zeng
Objective: We sought to investigate the clinical characteristics and risk factors of antiphospholipid syndrome (APS) complicated by autoimmune hemolytic anemia (AIHA). Methods: Retrospective anaysis.Three hundred fifteen consecutive patients with APS were enrolled at the Department of Rheumatology of Peking Union Medical College Hospital between May 2017 to May 2021, and their clinical manifestations[including initial symptoms, time interval between APS onset and diagnosis, systemic lupus erythematosus(SLE), thrombotic events, obstetric morbidity, and extra-criteria manifestations] and laboratory test results[including blood routine, antiphospholipid antibodies(aPLs), blood lipid profile, homocysteine, anti-nuclear antibody profile, immunoglobulin levels, and complement levels] were collected...
February 1, 2023: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://read.qxmd.com/read/36642429/the-role-of-complement-in-autoimmune-disease-associated-thrombotic-microangiopathy-and-the-potential-for-therapeutics
#26
REVIEW
Anuja Java, Alfred H J Kim
The complement system is a tightly regulated, cascading protein network representing a key component linking the innate and humoral immune systems. However, if misdirected or dysregulated, it can be similarly damaging to host-tissue. The role of complement dysregulation on vascular endothelial cells has been well established in atypical hemolytic uremic syndrome (aHUS), a thrombotic microangiopathy (TMA) characterized by microangiopathic hemolytic anemia, thrombocytopenia, and target organ injury. Yet, a great deal of complexity exists around the role of complement in TMA associated with other diseases...
June 2023: Journal of Rheumatology
https://read.qxmd.com/read/36633606/-thrombotic-microangiopathy
#27
REVIEW
Tilman Schmidt, Tobias B Huber
In the emergency room, patients with anemia and thrombocytopenia are common. Although these findings can often be explained by the medical situation, thrombotic microangiopathy is an important differential diagnosis. In this case, occlusion of the smallest vessels consequently leads to functional impairment of the affected organs. Patients generally present with symptoms of organ dysfunction, e.g., in the kidney or brain. Characteristically, Coombs-negative fragmentation of erythrocytes with hemolysis occurs in the area of the occluded vessels...
February 2023: Medizinische Klinik, Intensivmedizin und Notfallmedizin
https://read.qxmd.com/read/36415706/unique-hepatic-manifestations-of-covid-19-induced-immune-dysregulation-in-children
#28
Julia Kleinhenz, Ellen Wagner, Sarah Y Afzal, Homa Shaarbaf, Jorge Luis De Avila, Ruba Azzam
The two cases we present are the first to demonstrate novel manifestations of COVID-19 related interaction between the liver and the immune system in pediatric patients. Written informed consent was obtained from the parent/guardian to publish this report in accordance with the journal's patient consent policy.
November 2022: Clinical Case Reports
https://read.qxmd.com/read/36294407/neurovascular-manifestations-of-iron-deficient-anemia-narrative-review-and-practical-reflections-through-a-teaching-case
#29
Marialuisa Zedde, Giacomo Portaro, Laura Ferri, Francesco Cavallieri, Manuela Napoli, Claudio Moratti, Fabrizio Piazza, Franco Valzania, Rosario Pascarella
Anemia is one of the most frequent diseases worldwide, affecting one-third of the general population. Anemia in general and in particular, iron-deficient anemia (IDA), has been associated to a higher risk of thrombotic manifestations, including ischemic stroke and cerebral venous thrombosis (CVT), as well as systemic extra-cerebral arterial and venous thrombosis. Despite these data, anemia is seldom considered as an etiological factor of stroke. An individual case encompassing all known neurovascular and systemic arterial and venous thrombotic manifestations related to IDA is presented with the focus on clinical reasoning issues in the diagnostic pathways, starting from the neuroradiological signs...
October 15, 2022: Journal of Clinical Medicine
https://read.qxmd.com/read/36206383/immunosuppression-use-in-primary-antiphospholipid-antibody-positive-patients-descriptive-analysis-of-the-antiphospholipid-syndrome-alliance-for-clinical-trials-and-international-networking-aps-action-clinical-database-and-repository-registry
#30
JOURNAL ARTICLE
Zeynep B Erton, Rebecca K Leaf, Danieli de Andrade, Ann E Clarke, Maria G Tektonidou, Vittorio Pengo, Savino Sciascia, Amaia Ugarte, H Michael Belmont, Maria Gerosa, Paul R Fortin, Chary Lopez-Pedrera, Tatsuya Atsumi, Zhouli Zhang, Hannah Cohen, Guilherme Ramires de Jesús, David W Branch, Denis Wahl, Laura Andreoli, Esther Rodriguez-Almaraz, Michelle Petri, Giuseppe Barilaro, Yu Zuo, Bahar Artim-Esen, Rohan Willis, Rosana Quintana, Margarete Bg Vendramini, Megan W Barber, Maria L Bertolaccini, Robert Roubey, Doruk Erkan
BACKGROUND/PURPOSE: APS ACTION Registry was created to study the outcomes of patients with persistently positive antiphospholipid antibodies (aPL) with or without other systemic autoimmune disease (SAIDx). Given that immunosuppression (IS) is used for certain aPL manifestations, for example, thrombocytopenia (TP), our primary objective was to describe the indications for IS in aPL-positive patients without other SAIDx. Secondly, we report the type of IS used in patients with selected microvascular or non-thrombotic aPL manifestations...
December 2022: Lupus
https://read.qxmd.com/read/36189083/uncommon-cause-of-internal-mammary-artery-pseudoaneurysm
#31
Rohan M Prasad, Jason Z Liu, Christopher Garces, Ayushma Duwadi, James Choi, Farah Anwar, Adesuwa Olomu
Background: Internal mammary artery pseudoaneurysms most commonly develop from thoracic penetrating trauma or procedures. However, other important etiologies should not be overlooked. Case Report: A 27-year-old female presented with antiphospholipid antibody syndrome, thrombotic microangiopathy, end-stage renal disease on hemodialysis, and epilepsy. On admission, the patient had pulseless electrical activity and hypertensive emergency. After the patient was successfully resuscitated, she developed status epilepticus...
2022: Ochsner Journal
https://read.qxmd.com/read/36175215/hematological-manifestations-of-antiphospholipid-syndrome-going-beyond-thrombosis
#32
REVIEW
Georges El Hasbani, Antoine N Saliba, Imad Uthman, Ali T Taher
Thrombotic complications are a hallmark of antiphospholipid syndrome (APS). These vascular - arterial, venous, and/or small vessel - complications are well described and known to hematologists and healthcare providers caring for patients with this disease. In this review, we shed light on other hematological manifestations of the disease, including bleeding, thrombocytopenia, autoimmune hemolytic anemia, and thrombotic microangiopathy syndromes. While these manifestations are not bona fide clinical criteria for the diagnosis of APS, they frequently interact and contribute to the complexity of clinical management of APS...
March 2023: Blood Reviews
https://read.qxmd.com/read/36164122/tcl-084-subcutaneous-panniculitis-like-t-cell-lymphoma-with-co-existing-lupus-panniculitis-a-case-report
#33
JOURNAL ARTICLE
Roski Alexis Arrabaca
INTRODUCTION: Subcutaneous panniculitis-like T-cell lymphoma (SPTL) is an extraordinary form of peripheral T-cell lymphoma, accounting for much less than 1% of all non-Hodgkin lymphoma. It usually happens amongst women with a median age of onset of 36 years. It can arise with autoimmune disease ~20%. SPTL may also coexist with different autoimmune diseases (e.g., lupus erythematosus [LE]) despite normal workup. CASE: A 44-year-old woman presented with a small, 2×2 cm mass on her right inner thigh that was erythematous, non-movable, and tender...
October 2022: Clinical Lymphoma, Myeloma & Leukemia
https://read.qxmd.com/read/36140482/new-approach-to-addison-disease-oral-manifestations-due-to-endocrine-dysfunction-and-comorbidity-burden
#34
REVIEW
Narcis Mihăiţă Bugălă, Mara Carsote, Loredana Elena Stoica, Dana Maria Albulescu, Mihaela Jana Ţuculină, Smaranda Adelina Preda, Ancuta-Ramona Boicea, Dragoș Ovidiu Alexandru
This review highlights oral anomalies with major clinical impact in Addison disease (AD), including dental health and dermatologic features, through a dual perspective: pigmentation issues and AD comorbidities with oral manifestations. Affecting 92% of AD patients, cutaneomucosal hyperpigmentation is synchronous with or precedes general manifestations by up to a decade, underlying melanocytic infiltration of the basal epidermal layer; melanophages in the superficial dermis; and, rarely, acanthosis, perivascular lymphocytic infiltrate, and hyperkeratosis...
August 28, 2022: Diagnostics
https://read.qxmd.com/read/35971316/autoimmune-hemolytic-anemia-as-an-initial-presentation-in-children-with-systemic-lupus-erythematosus-two-case-reports
#35
JOURNAL ARTICLE
Yan Lu, Xian-Mei Huang
We report the cases of two children who presented with autoimmune hemolytic anemia (AIHA) as an initial presentation of systemic lupus erythematosus (SLE). Both patients had a positive Coombs test, anemia, and an increased number of spherocytes in their blood smear. The patient in Case 1 presented with fever, urticarial erythema, facial paresis, AIHA, and leucopenia. Immunological screening revealed low complement protein levels and positive anti-nuclear antibody, anti-double-stranded DNA, and antiphospholipid antibody results...
August 2022: Journal of International Medical Research
https://read.qxmd.com/read/35938616/catastrophic-antiphospholipid-syndrome-with-epstein-barr-virus-associated-hemophagocytosis-a-clinicopathological-conference
#36
JOURNAL ARTICLE
Aya Nawata, Rie Shirayama, Koichi Oshida, Tetsuji Sato, Takuma Ito, Eisuke Shiba, Koichi Kusuhara, Masanori Hisaoka
Catastrophic antiphospholipid syndrome (CAPS) is a severe variant of antiphospholipid syndrome associated with multiorgan thrombosis in a short term. We present the case of a 14-year-old immunocompetent girl who developed renal, intestinal, and pulmonary infarction; thrombocytopenia; and hemolytic anemia within 1 week. She was diagnosed with thrombotic microangiopathy. Hence, plasma exchange and corticosteroid therapy were initiated, which improved thrombocytopenia. However, the patient's platelet count decreased...
October 2022: Lupus
https://read.qxmd.com/read/35836439/evans-syndrome-in-the-context-of-incomplete-systemic-lupus-erythematosus
#37
Sarah Abu Kar, Amandeep Kaur
Evans syndrome is an autoimmune disorder characterized by the simultaneous or sequential occurrence of autoimmune hemolytic anemia and idiopathic thrombocytopenic purpura (ITP) with or without neutropenia. It can occur idiopathically or secondary to autoimmune or malignant processes. We are presenting a case of ITP with concurrent chronic hemolytic anemia and positive markers for systemic lupus erythematosus with no prior diagnosis of any rheumatological disorder.
June 2022: Curēus
https://read.qxmd.com/read/35796011/comparative-analysis-of-oral-and-intravenous-iron-therapy-in-rat-models-of-inflammatory-anemia-and-iron-deficiency
#38
JOURNAL ARTICLE
Lara Valente De Souza, Alexander Hoffmann, Christine Fischer, Verena Petzer, Malte Asshoff, Igor Theurl, Piotr Tymoszuk, Markus Seifert, Natascha Brigo, Richard Hilbe, Egon Demetz, Laura Von Raffay, Sylvia Berger, Marina Barros-Pinkelnig, Guenter Weiss
Anemia is a major health issue and associated with increased morbidity. Iron deficiency anemia (IDA) is the most prevalent, followed by anemia of chronic disease (ACD). IDA and ACD often coexist, challenging diagnosis and treatment. While iron supplementation is the first-line therapy for IDA, its optimal route of administration and the efficacy of different repletion strategies in ACD are elusive. Female Lewis rats were injected with group A streptococcal peptidoglycan-polysaccharide (PG-APS) to induce inflammatory arthritis with associated ACD and/or repeatedly phlebotomized and fed with low iron diet to induce IDA, or a combination thereof (ACD/IDA)...
July 7, 2022: Haematologica
https://read.qxmd.com/read/35783307/simultaneous-onset-of-pediatric-systemic-lupus-erythematosus-in-twin-brothers-case-report
#39
JOURNAL ARTICLE
Rinat K Raupov, Evgeny N Suspitsin, Artur I Imelbaev, Mikhail M Kostik
There are hundreds of twin adult patients with systemic lupus erythematosus (SLE), but male children with SLE are rarely affected. Two monozygotic twin brothers developed SLE at the age of 11 years during 1 month. The index brother manifested with Henoch-Shonlein purpura, accompanied by ANA positivity, and later developed critical left femoral arterial stenosis with high levels of anti-dsDNA, antiphospholipid antibodies, hypocomplementemia, and Coombs-positive hemolytic anemia. At that time his twin brother had only identical autoimmune findings and developed clinical manifestation (myositis and fasciitis) a month later...
2022: Frontiers in Pediatrics
https://read.qxmd.com/read/35746569/covid-19-vaccines-and-autoimmune-hematologic-disorders
#40
REVIEW
María Eva Mingot-Castellano, Nora Butta, Mariana Canaro, María Del Carmen Gómez Del Castillo Solano, Blanca Sánchez-González, Reyes Jiménez-Bárcenas, Cristina Pascual-Izquierdo, Gonzalo Caballero-Navarro, Laura Entrena Ureña, Tomás José González-López, On Behalf Of The Gepti
Worldwide vaccination against SARS-CoV-2 has allowed the detection of hematologic autoimmune complications. Adverse events (AEs) of this nature had been previously observed in association with other vaccines. The underlying mechanisms are not totally understood, although mimicry between viral and self-antigens plays a relevant role. It is important to remark that, although the incidence of these AEs is extremely low, their evolution may lead to life-threatening scenarios if treatment is not readily initiated...
June 16, 2022: Vaccines
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