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Hind limb ischemia

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https://www.readbyqxmd.com/read/28216514/diallyl-trisulfide-augments-ischemia-induced-angiogenesis-via-an-endothelial-nitric-oxide-synthase-dependent-mechanism
#1
Ryo Hayashida, Kazuhisa Kondo, Sumio Morita, Kazumasa Unno, Satoshi Shintani, Yuuki Shimizu, John W Calvert, Rei Shibata, Toyoaki Murohara
BACKGROUND: Hydrogen sulfide (H2S) exerts beneficial actions against the development of cardiovascular disease. Diallyl trisulfide (DATS) is an organic polysulfide found in garlic oil that liberates H2S under physiological conditions. This study investigated whether DATS modulates endothelial cell function, as well as revascularization processes in a mouse model of hind-limb ischemia.Methods and Results:Wild-type (WT), endothelial nitric oxide synthase-deficient (eNOS-KO) and Akt1-heterogenic deficient (Akt-Het) mice were subjected to unilateral hindlimb ischemia (HLI)...
February 17, 2017: Circulation Journal: Official Journal of the Japanese Circulation Society
https://www.readbyqxmd.com/read/28216347/systemic-application-of-carbon-monoxide-releasing-molecule-3-protects-skeletal-muscle-from-ischemia-reperfusion-injury
#2
Aurelia Bihari, Gediminas Cepinskas, Thomas L Forbes, Richard F Potter, Abdel-Rahman Lawendy
OBJECTIVE: Ischemia-reperfusion (IR) is a limb- and life-threatening complication of acute limb ischemia and musculoskeletal trauma. Carbon monoxide-releasing molecules (CORMs) have recently been shown to protect microvascular perfusion and to reduce inflammation and injury in various ischemic animal models. The purpose of this study was to examine the effects of water-soluble CORM-3 on the extent of IR-induced muscle injury. METHODS: Wistar rats were randomized into three groups: sham (no ischemia), IR + CORM-3 (10 mg/kg intraperitoneally), and IR + inactive CORM-3 (iCORM-3; 10 mg/kg intraperitoneally)...
February 16, 2017: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28210050/a-study-of-the-relationships-of-changes-in-pain-and-gait-after-tourniquet-induced-ischemia-reperfusion-in-rats
#3
Kazuki Aihara, Takeya Ono, Namiko Umei, Wakako Tsumiyama, Atsushi Tasaka, Hideki Ishikura, Yuta Sato, Tomohiro Matsumoto, Sadaaki Oki
[Purpose] The purpose of this study was to determine the relationships of changes in pain and gait after ischemia reperfusion was induced by tourniquet in rats. [Subjects and Methods] The subjects were six ten-week-old male Wistar rats. Ischemia was induced in the left lower limbs of the experimental rats at a pressure of 300 mmHg for 90 minutes. Pain behavior evaluations were measured using the von Frey test in all the rats' hind limbs. A consistently increasing plantar stimulus was applied until the rats exhibited an escape behavior...
January 2017: Journal of Physical Therapy Science
https://www.readbyqxmd.com/read/28207177/quaking-is-a-key-regulator-of-endothelial-cell-differentiation-neovascularization-and-angiogenesis
#4
Amy Cochrane, Sophia Kelaini, Marianna Tsifaki, James Bojdo, Marta Vilà-González, Daiana Drehmer, Rachel Caines, Corey Magee, Magdalini Eleftheriadou, Yanhua Hu, David Grieve, Alan W Stitt, Lingfang Zeng, Qingbo Xu, Andriana Margariti
The capability to derive endothelial cell (ECs) from induced Pluripotent Stem (iPS) cells holds huge therapeutic potential for cardiovascular disease. Objective- This study elucidates the precise role of the RNA-binding protein Quaking isoform 5 (QKI-5) during EC differentiation from both mouse and human iPS cells and dissects how RNA-binding proteins can improve differentiation efficiency towards cell therapy for important vascular diseases. iPS cells represent an attractive cellular approach for regenerative medicine today since they can be used to generate patient-specific therapeutic cells towards autologous cell therapy...
February 16, 2017: Stem Cells
https://www.readbyqxmd.com/read/28194544/exploring-the-role-of-trpv-and-cgrp-in-adenosine-preconditioning-and-remote-hind-limb-preconditioning-induced-cardioprotection-in-rats
#5
Amritpal Singh, Puneet Kaur Randhawa, Anjana Bali, Nirmal Singh, Amteshwar Singh Jaggi
The cardioprotective effects of remote hind limb preconditioning (RIPC) are well known, but mechanisms by which protection occurs still remain to be explored. Therefore, the present study was designed to investigate the role of TRPV and CGRP in adenosine and remote preconditioning-induced cardioprotection, using sumatriptan, a CGRP release inhibitor and ruthenium red, a TRPV inhibitor, in rats. For remote preconditioning, a pressure cuff was tied around the hind limb of the rat and was inflated with air up to 150 mmHg to produce ischemia in the hind limb and during reperfusion pressure was released...
February 14, 2017: Cardiovascular Drugs and Therapy
https://www.readbyqxmd.com/read/28188848/electroacupuncture-preconditioning-and-postconditioning-inhibit-apoptosis-and-neuroinflammation-induced-by-spinal-cord-ischemia-reperfusion-injury-through-enhancing-autophagy-in-rats
#6
Bo Fang, Meiman Qin, Yun Li, Xiaoqian Li, Wenfei Tan, Ying Zhang, Hong Ma
Electroacupuncture (EA) has beneficial effects on spinal cord ischemia reperfusion (I/R) injury, but the underlying mechanisms are not fully understood. This study aimed to investigate the role of autophagy in the protection of EA preconditioning and postconditioning against spinal cord I/R injury. For this, spinal cord I/R injury was induced by 14min occlusion of the aortic arch, and rats were treated with EA for 20min before or after the surgery. The expression of autophagy components, light chain 3 and Beclin 1, was assessed by Western blot...
February 7, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28167285/nanoparticular-delivery-system-for-a-secretoneurin-derivative-induces-angiogenesis-in-a-hind-limb-ischemia-model
#7
Karin Albrecht-Schgoer, Jan Barthelmes, Wilfried Schgoer, Markus Theurl, Isabelle Nardin, Daniela Lener, Clemens Gutmann, Sarah Dünnhaupt, Andreas Bernkop-Schnürch, Rudolf Kirchmair
Common therapeutic strategies for peripheral arterial disease often fail to re-establish sufficient blood flow within legs and feet of patients for avoiding critical limb ischemia, what is characterized by a substantial risk for amputation. The neuropeptide secretoneurin induces angiogenesis in models of limb and myocardial ischemia and might be a promising tool in the treatment of patients without the option of revascularization therapy for severe ischemia. Within this manuscript, the biologically active part of secretoneurin was identified, modified by induction of a cysteine residue to gain higher stability against enzymatic degradation and further packed into S-protected thiolated chitosan nanoparticles, which enable intra-muscular application of secretoneurin...
February 3, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28163177/venous-shunt-versus-venous-ligation-for-vascular-damage-control-the-immuno-histochemical-evidence
#8
Adenauer Marinho de Oliveira Góes Junior, Simone de Campos Vieira Abib, Maria Teresa de Seixas Alves, Paulo Sérgio Venerando da Silva Ferreira, Mariseth Carvalho de Andrade
OBJECTIVES: To evaluate the expression of immuno-histochemical markers of tissue ischemia (iNOS, eNOS and HSP70) in a vascular damage control experimental model in order to determine if a venous temporary vascular shunt insertion leads to a better limb perfusion when compared to the ligature of the injured vein. METHODS: Experimental study in male Sus Scrofa weighting 40 Kg. Animals were distributed into 5 groups: group 1 animals were submitted to right external iliac artery (EIA) shunting and right external iliac vein (EIV) ligation; group 2 animals were submitted to right EIA shunting and right EIV shunting; group 3 animals were submitted to right EIV ligation; group 4 animals were submitted to right EIV shunting; group 5 animals were not submitted to vascular shunting nor venous ligation...
February 2, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28128066/beneficial-effects-of-sildenafil-on-tissue-perfusion-and-inflammation-in-a-murine-model-of-limb-ischemia-and-atherosclerosis
#9
Aggeliki Valatsou, Alexandros Briasoulis, Georgia Vogiatzi, Alsistis Pantopoulou, Evangelos Oikonomou, Antigoni Miliou, Despina Perrea, Dimitris Tousoulis
BACKGROUND: Sildenafil, a phosphodiesterase type 5 (PDE5) inhibitor, has endothelium protective and angiogenic effects. OBJECTIVES: To test if sildenafil improves tissue perfusion and neovascularization and downregulates pro-inflammatory molecules following limb ischemia. METHODS: 30 ApoE-/- male mice, bred with cholesterol rich diet for 4 weeks, were anesthetized and underwent unilateral hind-limb ischemia with ligation of the left femoral artery...
January 26, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28109110/-effects-of-polyethylene-oxide-on-blood-perfusion-in-the-hind-limbs-of-rats-with-chronic-hindlimb-ischemia
#10
De-Zhong Zheng, Tao Zhou, Dao-Gang Zha
OBJECTIVE: To evaluate the effects of polyethylene oxide (PEO) on blood perfusion in hind limb skeletal muscles in a rat model of chronic hind limb ischemia. METHDOS: Twelve rat models of chronic hind limb ischemia established by unilateral femoral artery ligation were randomized into PEO and control groups (n=6) and treated with intravenous infusion of PEO and saline through the internal jugular vein every other day for 2 weeks. Contrast-enhanced ultrasonography was performed after the treatments to evaluate the blood flow in the skeletal muscles at different time points and blood flow reserve in the ischemic hind limbs on day 28...
January 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28095625/potentiation-of-biological-effects-of-mesenchymal-stem-cells-in-ischemic-conditions-by-melatonin-via-upregulation-of-cellular-prion-protein-expression
#11
Jun Hee Lee, Yong-Seok Han, Sang Hun Lee
Mesenchymal stem cells (MSCs) are promising candidates for stem cell-based therapy in ischemic diseases. However, ischemic injury induces pathophysiological conditions, such as oxidative stress and inflammation, which diminish therapeutic efficacy of MSC-based therapy by reducing survival and functionality of transplanted MSCs. To overcome this problem, we explored the effects of melatonin on the proliferation, resistance to oxidative stress, and immunomodulatory properties of MSCs. Treatment with melatonin enhanced MSC proliferation and self-renewal via upregulation of cellular prion protein (PrP(C) ) expression...
January 17, 2017: Journal of Pineal Research
https://www.readbyqxmd.com/read/28053524/dynamic-imaging-of-allogeneic-adipose-derived-regenerative-cells-transplanted-in-ischemic-hind-limb-of-apolipoprotein-e-mouse-model
#12
Yi Zheng, Jinbao Qin, Xin Wang, Zhiyou Peng, Peiyong Hou, Xinwu Lu
BACKGROUND: Transplantation of allogeneic adipose-derived regenerative cells (ADRCs) is a promising treatment modality for severe ischemic diseases. However, minimal information is available on the in vivo effects, fate, and migration of ADRCs, as well as the mechanisms of their therapeutic angiogenesis. MATERIALS AND METHODS: In this study, green fluorescent protein-expressing ADRCs (GFP-ADRCs) were obtained, labeled with acetylated 3-aminopropyltrimethoxysilane (APTS)-coated iron oxide nanoparticles (APTS NPs), and injected into an old apolipoprotein E knockout (ApoE-KO) mouse model with hind limb ischemia...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/28042553/remote-ischemic-preconditioning-enhances-the-expression-of-genes-encoding-antioxidant-enzymes-and-endoplasmic-reticulum-stress-related-proteins-in-rat-skeletal-muscle
#13
Ui Jun Park, Hyoung Tae Kim, Won Hyun Cho, Jae Hyoung Park, Hye Ra Jung, Min Young Kim
PURPOSE: Ischemic preconditioning (IPC), including remote IPC (rIPC) and direct IPC (dIPC), is a promising method to decrease ischemia-reperfusion (IR) injury. This study tested the effect of both rIPC and dIPC on the genes for antioxidant enzymes and endoplasmic reticulum (ER) stress-related proteins. MATERIALS AND METHODS: Twenty rats were randomly divided into the control and study groups. In the control group (n=10), the right hind limb was sham-operated. The left hind limb (IscR) of the control group underwent IR injury without IPC...
December 2016: Vascular Specialist International
https://www.readbyqxmd.com/read/28024849/diminished-force-production-and-mitochondrial-respiratory-deficits-are-strain-dependent-myopathies-of-subacute-limb-ischemia
#14
Cameron A Schmidt, Terence E Ryan, Chien-Te Lin, Melissa M R Inigo, Tom D Green, Jeffrey J Brault, Espen E Spangenburg, Joseph M McClung
OBJECTIVE: Reduced skeletal muscle mitochondrial function might be a contributing mechanism to the myopathy and activity based limitations that typically plague patients with peripheral arterial disease (PAD). We hypothesized that mitochondrial dysfunction, myofiber atrophy, and muscle contractile deficits are inherently determined by the genetic background of regenerating ischemic mouse skeletal muscle, similar to how patient genetics affect the distribution of disease severity with clinical PAD...
December 23, 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/28017783/anti-apoptotic-and-angiogenic-effects-of-intelectin-1-in-rat-cerebral-ischemia
#15
Naibing Gu, Yaru Dong, Ye Tian, Zhengli Di, Zhiqin Liu, Mingze Chang, Xiaotao Jia, Yihua Qian, Weiping Zhang
Ischemic stroke is an acute life-threatening disease, which causes neurological dysfunction. The formation of new blood vessels around the infarct is vital to the restoration of perfusion and healing of brain tissue. Studies have shown that intelectin-1 (omentin) promotes endothelial cell function and angiogenesis in response to ischemia and inhibits apoptosis in rats with unilateral hind limb surgery. In the present study, we investigated the neuroprotective role of intelectin-1 following focal cerebral ischemia...
December 23, 2016: Brain Research Bulletin
https://www.readbyqxmd.com/read/28006943/cardioprotection-induced-by-remote-ischemic-preconditioning-preserves-the-mitochondrial-respiratory-function-in-acute-diabetic-myocardium
#16
I Kancirová, M Jašová, M Muráriková, Z Sumbalová, O Uličná, T Ravingerová, I Waczulíková, A Ziegelhöffer, M Ferko
A 2×2 factorial design was used to evaluate possible preservation of mitochondrial functions in two cardioprotective experimental models, remote ischemic preconditioning and streptozotocin-induced diabetes mellitus, and their interaction during ischemia/reperfusion injury (I/R) of the heart. Male Wistar rats were randomly allocated into four groups: control (C), streptozotocin-induced diabetic (DM), preconditioned (RPC) and preconditioned streptozotocin-induced diabetic (DM+RPC). RPC was conducted by 3 cycles of 5-min hind-limb ischemia and 5-min reperfusion...
December 22, 2016: Physiological Research
https://www.readbyqxmd.com/read/27998712/impacts-of-femoral-artery-and-vein-excision-versus-femoral-artery-excision-on-the-hindlimb-ischemic-model-in-cd-1-mice
#17
Miao Chen, Huimin Fan, Benjamin T Ledford, Zayd Farah, Catherine Barron, Zhongmin Liu, Jia-Qiang He
BACKGROUND AND AIM: Although femoral artery ligation-induced ischemia is commonly used in C57BL/6 or Balb/c mice, direct comparisons between femoral artery/vein (FAV) versus femoral artery (FA) excisions have not been reported. The goal of the present study is to investigate the effects of FAV versus FA excisions on hindlimb models using adult CD-1 mice. METHODS: Two groups (n=10/group) of adult, mixed gender CD-1 mice were used to generate hindlimb ischemic models by excising either the FAV or FA...
December 18, 2016: Microvascular Research
https://www.readbyqxmd.com/read/27986757/cyanate-impaired-angiogenesis-association-with-poor-coronary-collateral-growth-in-patients-with-stable-angina-and-chronic-total-occlusion
#18
Jia Teng Sun, Ke Yang, Jing Yan Mao, Wei Feng Shen, Lin Lu, Qi Hong Wu, Yan Ping Wang, Li Ping Wu, Rui Yan Zhang
BACKGROUND: Cyanate has recently gained attention for its role in the pathogenesis of vascular injury. Nonetheless, the effect of cyanate on angiogenesis remains unclear. METHODS AND RESULTS: In this study, we demonstrated that oral administration of cyanate impaired blood perfusion recovery in a mouse hind-limb ischemia model. A reduction in blood perfusion recovery at day 21 was observed in the ischemic tissue of cyanate-treated mice. Likewise, there were fewer capillaries in the ischemic hind-limb tissue of cyanate-exposed mice...
December 16, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27984781/simvastatin-augments-revascularization-and-reperfusion-in-a-murine-model-of-hind-limb-ischemia-multimodal-imaging-assessment
#19
Julian Luke Goggi, Michael Ng, Nalini Shenoy, Ramasamy Boominathan, Peter Cheng, Sakthivel Sekar, Kishore Kumar Bhakoo
INTRODUCTION: Peripheral artery disease can lead to severe disability and limb loss. Therapeutic strategies focussing on macrovascular repair have shown benefit but have not significantly reduced amputation rates in progressive PAD. Proangiogenic small molecule therapies may substantially improve vascularisation in limb ischemia. The purpose of the current study was to assess the proangiogenic effects of simvastatin in a murine model of hind limb ischemia using longitudinal multimodal imaging...
November 17, 2016: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/27941593/low-dose-sodium-nitrite-fluid-resuscitation-prevents-lethality-from-crush-syndrome-by-improving-nitric-oxide-consumption-and-preventing-myoglobin-cytotoxicity-in-kidney-in-a-rat-model
#20
Isamu Murata, Yumi Miyake, Naomi Takahashi, Ryuta Suzuki, Takayuki Fujiwara, Yuji Sato, Yutaka Inoe, Jun Kobayashi, Ikuo Kanamoto
OBJECTIVE: Crush syndrome (CS) is a serious medical condition characterized by muscle cell damage resulting from pressure. CS has a high mortality, even when patients receive fluid therapy. We examined whether administration of NaNO2-containing fluid can improve survival in a rat model of CS. DESIGN: The CS model was generated by subjecting anesthetized rats to bilateral hind limb compression with a rubber tourniquet for 5 h. Rats were then randomly divided into six groups: (i) sham; (ii) CS with no treatment; (iii) CS with normal saline treatment; (iv) CS with normal saline + 25 mEq/L bicarbonate treatment; and (v and vi) CS with normal saline + 200 or 500 μmol/kg NaNO2...
December 9, 2016: Shock
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