keyword
MENU ▼
Read by QxMD icon Read
search

Utilization segmentation

keyword
https://www.readbyqxmd.com/read/29149195/age-of-heart-disease-presentation-and-dysmorphic-nuclei-in-patients-with-lmna-mutations
#1
Jason Q Core, Mehrsa Mehrabi, Zachery R Robinson, Alexander R Ochs, Linda A McCarthy, Michael V Zaragoza, Anna Grosberg
Nuclear shape defects are a distinguishing characteristic in laminopathies, cancers, and other pathologies. Correlating these defects to the symptoms, mechanisms, and progression of disease requires unbiased, quantitative, and high-throughput means of quantifying nuclear morphology. To accomplish this, we developed a method of automatically segmenting fluorescently stained nuclei in 2D microscopy images and then classifying them as normal or dysmorphic based on three geometric features of the nucleus using a package of Matlab codes...
2017: PloS One
https://www.readbyqxmd.com/read/29145797/14-3-3%C3%AF-protein-expression-in-canine-renal-cell-carcinomas
#2
Alejandro Suárez-Bonnet, Ana Lara-García, Alexander L Stoll, Sofia Carvalho, Simon L Priestnall
14-3-3σ is a protein expressed in many epithelial tissues associated with essential cell functions, including cell-cycle control, apoptosis, and cytoskeletal integrity. There is a paucity of knowledge of the tumorigenesis of canine renal cell carcinomas (RCCs), and the histological origin of this tumor has not been established. This study analyzed the expression of 14-3-3σ, Ki-67, cytokeratins, and vimentin in 40 canine RCCs. Aberrant expression of 14-3-3σ was demonstrated in 15 (38%) cases and was associated with a significantly shorter survival time ( P < ...
January 1, 2017: Veterinary Pathology
https://www.readbyqxmd.com/read/29141589/reconstructing-cancer-karyotypes-from-short-read-data-the-half-empty-and-half-full-glass
#3
Rami Eitan, Ron Shamir
BACKGROUND: During cancer progression genomes undergo point mutations as well as larger segmental changes. The latter include, among others, segmental deletions duplications, translocations and inversions.The result is a highly complex, patient-specific cancer karyotype. Using high-throughput technologies of deep sequencing and microarrays it is possible to interrogate a cancer genome and produce chromosomal copy number profiles and a list of breakpoints ("jumps") relative to the normal genome...
November 15, 2017: BMC Bioinformatics
https://www.readbyqxmd.com/read/29141008/smartphone-based-quantitative-measurements-on-holographic-sensors
#4
Gita Khalili Moghaddam, Christopher Robin Lowe
The research reported herein integrates a generic holographic sensor platform and a smartphone-based colour quantification algorithm in order to standardise and improve the determination of the concentration of analytes of interest. The utility of this approach has been exemplified by analysing the replay colour of the captured image of a holographic pH sensor in near real-time. Personalised image encryption followed by a wavelet-based image compression method were applied to secure the image transfer across a bandwidth-limited network to the cloud...
2017: PloS One
https://www.readbyqxmd.com/read/29139034/vessel-centerline-reconstruction-from-non-isocentric-and-non-orthogonal-paired-monoplane-angiographic-images
#5
Mie Kunio, Caroline C O'Brien, Augusto C Lopes, Lynn Bailey, Pedro A Lemos, Guillermo J Tearney, Elazer R Edelman
PURPOSE: Three-dimensional reconstruction of a vessel centerline from paired planar coronary angiographic images is critical to reconstruct the complex three-dimensional structure of the coronary artery lumen and the relative positioning of implanted devices. In this study, a new vessel centerline reconstruction method that can utilize non-isocentric and non-orthogonal pairs of angiographic images was developed and tested. METHODS: Our new method was developed in in vitro phantom models of bifurcated coronary artery with and without stent, and then tested in in vivo swine models (twelve coronary arteries)...
November 14, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/29138527/longitudinal-analysis-of-mouse-sdoct-volumes
#6
Bhavna J Antony, Aaron Carass, Andrew Lang, Byung-Jin Kim, Donald J Zack, Jerry L Prince
Spectral-domain optical coherence tomography (SDOCT), in addition to its routine clinical use in the diagnosis of ocular diseases, has begun to find increasing use in animal studies. Animal models are frequently used to study disease mechanisms as well as to test drug efficacy. In particular, SDOCT provides the ability to study animals longitudinally and non-invasively over long periods of time. However, the lack of anatomical landmarks makes the longitudinal scan acquisition prone to inconsistencies in orientation...
February 11, 2017: Proceedings of SPIE
https://www.readbyqxmd.com/read/29138254/estimating-realized-heritability-in-panmictic-populations
#7
Milan Lstibůrek, Václav Bittner, Gary R Hodge, Jan Picek, Trudy F C Mackay
Narrow sense heritability (h(2) ) is a key concept in quantitative genetics, as it expresses the proportion of the observed phenotypic variation that is transmissible from parents to offspring. h(2) determines the resemblance among relatives and the rate of response to artificial and natural selection. Classical methods for estimating h(2) use random samples of individuals with known relatedness, as well as response to artificial selection, when it is called realized heritability. Here, we present a method for estimating realized h(2) based on a simple assessment of a random-mating population with no artificial manipulation of the population structure, and derive standard errors of the estimates...
November 14, 2017: Genetics
https://www.readbyqxmd.com/read/29137225/circular-rna-expression-profile-and-potential-function-of-hsa_circrna_101238-in-human-thoracic-aortic-dissection
#8
Meisheng Zou, Chixiong Huang, Xinzhong Li, Xiang He, Yanmei Chen, Wangjun Liao, Yulin Liao, Jie Sun, Ze Liu, Lintao Zhong, Jianping Bin
Objective: To assess the circular RNAs (circRNAs) expression profile and explore the potential functions in human thoracic aortic dissection (TAD). Methods: The differentially expressed circRNAs profiles of the aortic segments between human type A TAD patients (n=3) and age-matched normal donors (NA; n=3) were analyzed using the Arraystar human circRNAs microarray. Quantitative real-time PCR was used to validate the expression pattern of circRNAs, parental genes, and hsa-miR-320a; Western blotting confirmed MMP9 expression with additional samples...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29134725/reproducibility-of-brain-mri-segmentation-algorithms-empirical-comparison-of-local-map-pstaple-freesurfer-and-fsl-first
#9
Clemente Velasco-Annis, Alireza Akhondi-Asl, Aymeric Stamm, Simon K Warfield
BACKGROUND AND PURPOSE: Segmentation of human brain structures is crucial for the volumetric quantification of brain disease. Advances in algorithmic approaches have led to automated techniques that save time compared to interactive methods. Recently, the utility and accuracy of template library fusion algorithms, such as Local MAP PSTAPLE (PSTAPLE), have been demonstrated but there is little guidance regarding its reproducibility compared to single template-based algorithms such as FreeSurfer and FSL-FIRST...
November 14, 2017: Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging
https://www.readbyqxmd.com/read/29133337/identification-of-myocardial-infarction-type-from-electronic-hospital-data-in-england-and-australia-a-comparative-data-linkage-study
#10
Lee Nedkoff, Derrick Lopez, Michael Goldacre, Frank Sanfilippo, Michael Hobbs, F Lucy Wright
OBJECTIVE: To determine the utility of International Classification of Diseases (ICD) codes in investigating trends in ST-segment elevation myocardial infarction (STEMI) and non-ST-segment elevation myocardial infarction (NSTEMI) using person-linked electronic hospitalisation data in England and Western Australia (WA). METHODS: All hospital admissions with myocardial infarction (MI) as the principal diagnosis were identified from 2000 to 2013 from both jurisdictions...
November 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/29131363/automatic-renal-lesion-segmentation-in-ultrasound-images-based-on-saliency-features-improved-lbp-and-an-edge-indicator-under-level-set-framework
#11
Luying Gui, Xiaoping Yang
PURPOSE: Segmentation of lesions in ultrasound images is widely used for preliminary diagnosis. In this paper, we develop an automatic segmentation algorithm for multiple types of lesions in ultrasound images. The proposed method is able to detect and segment lesions automatically as well as generate accurate segmentation results for lesion regions. METHODS: In the detection step, two saliency detection frameworks which adopt global image information are designed to capture the differences between normal and abnormal organs as well as these between lesions and the normal tissues around them...
November 13, 2017: Medical Physics
https://www.readbyqxmd.com/read/29129481/image-processing-strategies-based-on-saliency-segmentation-for-object-recognition-under-simulated-prosthetic-vision
#12
Heng Li, Xiaofan Su, Jing Wang, Han Kan, Tingting Han, Yajie Zeng, Xinyu Chai
BACKGROUND AND OBJECTIVE: Current retinal prostheses can only generate low-resolution visual percepts constituted of limited phosphenes which are elicited by an electrode array and with uncontrollable color and restricted grayscale. Under this visual perception, prosthetic recipients can just complete some simple visual tasks, but more complex tasks like face identification/object recognition are extremely difficult. Therefore, it is necessary to investigate and apply image processing strategies for optimizing the visual perception of the recipients...
November 9, 2017: Artificial Intelligence in Medicine
https://www.readbyqxmd.com/read/29129125/clinical-efficacy-and-safety-of-a-highly-conformal-supine-hybrid-forward-and-inverse-planned-intensity-modulated-radiation-therapy-technique-for-craniospinal-irradiation
#13
Safia K Ahmed, Jon J Kruse, Thomas B Bradley, Chris J Beltran, Nadia N Issa Laack
PURPOSE: To demonstrate the clinical efficacy and safety of a highly conformal, supine, hybrid forward and inverse planned intensity modulated radiation therapy (IMRT) technique for photon craniospinal irradiation (CSI). METHODS: Patients who received supine, hybrid IMRT CSI from 2009 to 2014 were included in this retrospective review. Clinical target volume (CTV) was defined as intracranial contents and thecal sac, including nerve roots. Dose was prescribed such that >99% of CTV received >99% of prescription and >95% of the planning target volume received >95% of prescription, with no attempt to include vertebral bodies...
November 12, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29127999/high-resolution-isotropic-three-dimensional-mr-imaging-of-the-extraforaminal-segments-of-the-cranial-nerves
#14
REVIEW
Jessica Wen, Naman S Desai, Dean Jeffery, Nafi Aygun, Ari Blitz
High-resolution isotropic 3-dimensional (D) MR imaging with and without contrast is now routinely used for imaging evaluation of cranial nerve anatomy and pathologic conditions. The anatomic details of the extraforaminal segments are well-visualized on these techniques. A wide range of pathologic entities may cause enhancement or displacement of the nerve, which is now visible to an extent not available on standard 2D imaging. This article highlights the anatomy of extraforaminal segments of the cranial nerves and uses select cases to illustrate the utility and power of these sequences, with a focus on constructive interference in steady-state...
February 2018: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/29126206/the-incidence-and-origin-of-segmental-aneuploidy-in-human-oocytes-and-preimplantation-embryos
#15
D Babariya, E Fragouli, S Alfarawati, K Spath, D Wells
STUDY QUESTION: What is the incidence, origin and clinical significance of segmental aneuploidy in human oocytes and preimplantation embryos? SUMMARY ANSWER: Segmental aneuploidy occurs at a considerable frequency in preimplantation embryos with a majority being mitotic in origin. WHAT IS KNOWN ALREADY: In recent years, accurate techniques for the detection of aneuploidy in single cells have been developed. Research using such methods has confirmed that aneuploidy is a common feature of human oocytes and preimplantation embryos...
November 8, 2017: Human Reproduction
https://www.readbyqxmd.com/read/29125784/identifying-the-population-with-serious-illness-the-denominator-challenge
#16
Amy S Kelley, Evan Bollens-Lund
BACKGROUND: To ensure seriously ill people and their families receive high-quality primary and specialty palliative care services, rigorous methods are needed to prospectively identify this population. OBJECTIVE: To define and operationalize a definition of serious illness for the purpose of identifying patients and caregivers who need primary or specialty palliative care services. DESIGN/SETTING: Two stages of work included (1) building expert consensus around a conceptual definition of serious illness and (2) using the National Health and Aging Trends Study linked to Medicare claims data to test a range of operational definitions composed of diagnoses, utilization, and markers of care needs...
November 10, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/29124793/evidence-for-allosteric-effects-on-p53-oligomerization-induced-by-phosphorylation
#17
Petr Muller, Juliana M Chan, Oliver Simoncik, Miroslav Fojta, David P Lane, Ted Hupp, Borivoj Vojtesek
P53 is a tetrameric protein with a thermodynamically unstable DNA-binding domain flanked by intrinsically disordered regulatory domains that control its activity. The unstable and disordered segments of p53 allow high flexibility as it interacts with binding partners and permits a rapid on/off switch to control its function. The p53 tetramer can exist in multiple conformational states, any of which can be stabilized by a particular modification. Here, we apply the allostery model to p53 to ask whether evidence can be found that the "activating" C-terminal phosphorylation of p53 stabilizes a specific conformation of the protein in the absence of DNA...
November 10, 2017: Protein Science: a Publication of the Protein Society
https://www.readbyqxmd.com/read/29124079/identifying-more-reliable-parameters-for-the-detection-of-change-during-the-follow-up-of-mild-to-moderate-keratoconus-patients
#18
Ivo Guber, Colm McAlinden, François Majo, Ciara Bergin
Background: Reaching a consensus on which parameters are most reliable at detecting progressive keratoconus patients with serial topography imaging is not evident. The aim of the study was to isolate the parameters best positioned to detect keratoconus progression using the Pentacam HR® measures based on the respective limits of repeatability and range of measurement. Method: Using the Pentacam HR®, a tolerance index was calculated on anterior segment parameters in healthy and keratoconic eyes...
2017: Eye and Vision (London, England)
https://www.readbyqxmd.com/read/29121928/a-yeast-two-hybrid-system-for-the-screening-and-characterization-of-small-molecule-inhibitors-of-protein-protein-interactions-identifies-a-novel-putative-mdm2-binding-site-in-p53
#19
Jin Huei Wong, Mohammad Alfatah, Mei Fang Sin, Hong May Sim, Chandra S Verma, David P Lane, Prakash Arumugam
BACKGROUND: Protein-protein interactions (PPIs) are fundamental to the growth and survival of cells and serve as excellent targets to develop inhibitors of biological processes such as host-pathogen interactions and cancer cell proliferation. However, isolation of PPI inhibitors is extremely challenging. While several in vitro assays to screen for PPI inhibitors are available, they are often expensive, cumbersome, and require large amounts of purified protein. In contrast, limited in vivo assays are available to screen for small-molecule inhibitors of PPI...
November 9, 2017: BMC Biology
https://www.readbyqxmd.com/read/29121588/infants-sensitivity-to-vowel-harmony-and-its-role-in-segmenting-speech
#20
Toben H Mintz, Rachel L Walker, Ashlee Welday, Celeste Kidd
A critical part of infants' ability to acquire any language involves segmenting continuous speech input into discrete word forms. Certain properties of words could provide infants with reliable cues to word boundaries. Here we investigate the potential utility of vowel harmony (VH), a phonological property whereby vowels within a word systematically exhibit similarity ("harmony") for some aspect of the way they are pronounced. We present evidence that infants with no experience of VH in their native language nevertheless actively use these patterns to generate hypotheses about where words begin and end in the speech stream...
November 6, 2017: Cognition
keyword
keyword
90216
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"