Siba El Hussein, Xiaoqiong Wang, Hong Fang, Fatima Zahra Jelloul, Wei Wang, Sanam Loghavi, Francisco Vega, Roberto N Miranda, Tariq Muzzafar, John T Manning, Joseph D Khoury, W Richard Burack, Andrew G Evans, L Jeffrey Medeiros
Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) with unusual features, including some that can overlap morphologically with classic Hodgkin lymphoma (CHL), have been described. Herein, we describe 12 cases of NLPHL with fibrous bands and capsular fibrosis resembling, in part, nodular sclerosis (NS) CHL. Seven of 12 cases harbored Reed-Sternberg-like cells, further suggestive of CHL, but all cases lacked associated eosinophils and/or plasma cells in the background. In this cohort, all cases had areas of so-called pattern D (nodular T-cell rich) as a sole component in 7 (58%) cases or as a hybrid pattern along with pattern E (diffuse T-cell/histiocyte-rich) in 5 (42%) cases...
September 1, 2022: American Journal of Surgical Pathology