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Renal injury obesity

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https://www.readbyqxmd.com/read/29432202/plasma-midregional-proadrenomedullin-mr-proadm-concentrations-and-their-biological-determinants-in-a-reference-population
#1
Magdalena Krintus, Marek Kozinski, Federica Braga, Jacek Kubica, Grazyna Sypniewska, Mauro Panteghini
BACKGROUND: Midregional proadrenomedullin (MR-proADM) is emerging as a prognostic biomarker for detecting the failure of multiple organs. Establishment of scientifically robust reference intervals facilitates interpretation of laboratory test results. The objectives of this study were (i) to establish reliable reference intervals for plasma MR-proADM using a commercially available automated fluoroimmunoassay in apparently healthy individuals, and (ii) to identify biological determinants of MR-proADM concentrations...
February 13, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29428203/outcomes-of-obese-and-morbidly-obese-patients-undergoing-percutaneous-coronary-intervention
#2
Elizabeth D Paratz, Luke E Wilkinson, Andrew I MacIsaac
BACKGROUND: The risks of percutaneous coronary intervention (PCI) in obese and particularly morbidly obese patients remain uncertain. METHODS: 1082 consecutive patients were categorised as non-obese (NO, body mass index (BMI) <30kg/m2, n=688), obese (O, BMI 30-40kg/m2, n=354) or morbidly obese (MO, BMI ≥40kg/m2, n=40). Demographic and procedural information was collated. Monte Carlo simulations modelled radiation dosimetric data. RESULTS: Obese and morbidly obese patients were younger (p=0...
September 18, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29415663/the-impact-of-disease-severity-on-paradoxical-association-between-body-mass-index-and-mortality-in-patients-with-acute-kidney-injury-undergoing-continuous-renal-replacement-therapy
#3
Hyoungnae Kim, Hyunwook Kim, Misol Lee, Min-Uk Cha, Ki Heon Nam, Seong Yeong An, Su-Young Jung, Jong Hyun Jhee, Seohyun Park, Hae-Ryong Yun, Youn Kyung Kee, Hyung Jung Oh, Jung Tak Park, Tae Ik Chang, Tae-Hyun Yoo, Shin-Wook Kang, Seung Hyeok Han
BACKGROUND: Association between high body mass index (BMI) and survival benefit is confounded by comorbid conditions such as nutritional status and inflammation. Patients with acute kidney injury (AKI), particularly those receiving continuous renal replacement therapy (CRRT), are highly catabolic and more susceptible to loss of energy. Herein, we evaluated whether disease severity can modify the relationship between BMI and mortality. METHODS: We conducted an observational study in 1144 patients who had undergone CRRT owing to various causes of AKI between 2010 and 2014...
February 7, 2018: BMC Nephrology
https://www.readbyqxmd.com/read/29408400/bariatric-surgery-prior-to-elective-posterior-lumbar-fusion-is-associated-with-reduced-medical-complications-and-infection
#4
Deeptee Jain, Sigurd Berven, John Carter, Alan L Zhang, Vedat Deviren
BACKGROUND CONTEXT: Severely obese patients with operative spinal pathology present a challenge to the spine surgeon, given the increased complication risk. PURPOSE: Determine the impact of bariatric surgery on perioperative complications of posterior lumbar fusion. STUDY DESIGN: Retrospective cohort study. PATIENT SAMPLE: Patients undergoing posterior lumbar fusion surgery in the State Inpatient Databases (SID) of New York, Florida, North Carolina, Nebraska, Utah, and California...
February 2, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29389945/intermittent-hypoxia-causes-histological-kidney-damage-and-increases-growth-factor-expression-in-a-mouse-model-of-obstructive-sleep-apnea
#5
Bisher Abuyassin, Mohammad Badran, Najib T Ayas, Ismail Laher
Epidemiological studies demonstrate an association between obstructive sleep apnea (OSA) and accelerated loss of kidney function. It is unclear whether the decline in function is due to OSA per se or to other confounding factors such as obesity. In addition, the structural kidney abnormalities associated with OSA are unclear. The objective of this study was to determine whether intermittent hypoxia (IH), a key pathological feature of OSA, induces renal histopathological damage using a mouse model. Ten 8-week old wild-type male CB57BL/6 mice were randomly assigned to receive either IH or intermittent air (IA) for 60 days...
2018: PloS One
https://www.readbyqxmd.com/read/29374876/-solitary-kidney-is-it-too-little
#6
REVIEW
Roxana Cleper
Solitary functioning kidney (SFK) occurs with unilateral renal agenesis (URA) in 1/2000 live births - or after uninephrectomy for tumor, trauma, uncontrolled infections or hypertension and post-kidney donation. URA-associated states include urological, cardiac, gastrointestinal and skeletal anomalies or it might be a component of a genetic syndrome. In 10% of cases of URA another family member is affected. In any case of SFK a compensatory process is triggered consisting of glomerular hypertension with hyperfiltration which achieves 75% of two kidneys' function...
January 2018: Harefuah
https://www.readbyqxmd.com/read/29374293/effects-of-the-sglt2-inhibitor-ipragliflozin-on-various-diabetic-symptoms-and-progression-of-overt-nephropathy-in-type-2-diabetic-mice
#7
Atsuo Tahara, Toshiyuki Takasu
Diabetic nephropathy is the leading cause of end-stage renal disease and is associated with high-cardiovascular risk and significant morbidity and mortality. The recent development of sodium-glucose cotransporter (SGLT) 2 inhibitors offers a new antidiabetic therapy via enhanced glucose excretion; however, the beneficial effect of these drugs on the development of type 2 diabetic overt nephropathy is still largely unclear. We examined the therapeutic effects of the SGLT2 inhibitor ipragliflozin on various diabetic symptoms and the progression of nephropathy in uninephrectomized type 2 diabetic mice, which exhibit not only typical diabetic symptoms, such as impaired insulin secretion, glucose intolerance, hyperglycemia, and obesity, but also overt nephropathy with decline in renal function...
January 26, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
https://www.readbyqxmd.com/read/29358013/perioperative-care-of-the-obese-cardiac-surgical-patient
#8
REVIEW
M Megan Chacon, Sreekanth R Cheruku, Peter J Neuburger, Laeben Lester, Sasha K Shillcutt
Morbid obesity is associated with impairment of cardiovascular, pulmonary, gastrointestinal, and renal physiology with significant perioperative consequences and has been linked with higher morbidity and mortality after cardiac surgery. Cardiac surgery patients have a higher incidence of difficult airway and difficult laryngoscopy than general surgery patients do, and obesity is associated with difficult mask ventilation and direct laryngoscopy. Positioning injuries occur more frequently because obese patients are at greater risk of pressure injury, such as rhabdomyolysis and compartment syndrome...
December 13, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29346138/obesity-and-chronic-kidney-disease
#9
Edward Nehus
PURPOSE OF REVIEW: To review recent advances in the epidemiology, pathophysiology, clinical features, and treatment of obesity-related kidney disease. RECENT FINDINGS: Studies have confirmed that obesity is associated with increased risk of developing chronic kidney disease (CKD). This risk extends to those who are metabolically healthy, indicating that obesity per se contributes to CKD independent of the metabolic syndrome. Recent developments in the pathophysiology of obesity-related kidney disease indicate that chronic inflammation and abnormal lipid metabolism contribute to kidney cell injury...
January 17, 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29344022/role-of-body-mass-index-in-acute-kidney-injury-patients-after-cardiac-surgery
#10
Zhouping Zou, Yamin Zhuang, Lan Liu, Bo Shen, Jiarui Xu, Zhe Luo, Jie Teng, Chunsheng Wang, Xiaoqiang Ding
Background/Aims: To explore the association of body mass index (BMI) with the risk of developing acute kidney injury after cardiac surgery (CS-AKI) and for AKI requiring renal replacement therapy (AKI-RRT) after cardiac surgery. Methods: Clinical data of 8,455 patients undergoing cardiac surgery, including demographic preoperative, intraoperative, and postoperative data were collected. Patients were divided into underweight (BMI <18.5), normal weight (18.5≤ BMI <24), overweight (24≤ BMI <28), and obese (BMI ≥28) groups...
December 2017: Cardiorenal Medicine
https://www.readbyqxmd.com/read/29340699/long-term-expression-of-glomerular-genes-in-diabetic-nephropathy
#11
Dominik Chittka, Bernhard Banas, Laura Lennartz, Franz Josef Putz, Kathrin Eidenschink, Sebastian Beck, Thomas Stempfl, Christoph Moehle, Simone Reichelt-Wurm, Miriam C Banas
Background: Although diabetic nephropathy (DN) is the most common cause for end-stage renal disease in western societies, its pathogenesis still remains largely unclear. A different gene pattern of diabetic and healthy kidney cells is one of the probable explanations. Numerous signalling pathways have emerged as important pathophysiological mechanisms for diabetes-induced renal injury. Methods: Glomerular cells, as podocytes or mesangial cells, are predominantly involved in the development of diabetic renal lesions...
January 11, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29340529/association-between-syndecan-1-and-renal-function-in-adolescents-with-excess-weight-evidence-of-subclinical-kidney-disease-and-endothelial-dysfunction
#12
Z M R M Saboia, G C Meneses, A M C Martins, E F Daher, G B Silva Junior
Excess weight (overweight and obesity) is associated with kidney and cardiovascular disease. The aim of this study was to investigate the association between syndecan-1 and renal function among adolescents with excess weight. A total of 56 students from a public school at Fortaleza, CE, Brazil, were investigated. The adolescents were submitted to anthropometric evaluation, including weight, height, blood pressure and body mass index. Blood and urine samples were collected for the determination of serum lipids (total cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, triglycerides), and the endothelial injury biomarker syndecan-1...
January 11, 2018: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/29328453/aldosterone-is-involved-in-the-pathogenesis-of-obesity-related-glomerulopathy-through-activation-of-wnt-%C3%AE-catenin-signaling-in-podocytes
#13
Jia-Jia Zhu, Yi-Pu Chen, Min Yang, Bao-Li Liu, Jing Dong, Hong-Rui Dong, Hong-Liang Rui, Hong Cheng
Obesity-related glomerulopathy (ORG) is morphologically characterized by glomerulomegaly with or without observable focal segmental glomerulosclerosis under light microscope, with decreased podocyte density and number, and with increased foot‑process width observed under electron microscope. The severity of podocyte injury is correlated with the degree of proteinuria and renal dysfunction. However, the pathogenesis of ORG is not well understood. The aim of the present study was to explore the possible pathogenic role of aldosterone (ALDO) in ORG...
January 5, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29311094/pharmacokinetics-of-telavancin-at-fixed-doses-in-normal-body-weight-and-obese-classes-i-ii-and-iii-adult-subjects
#14
Kristen L Bunnell, Manjunath P Pai, Monica Sikka, Susan C Bleasdale, Eric Wenzler, Larry H Danziger, Keith A Rodvold
A recommended total body weight (TBW) dosing strategy for telavancin may not be optimal in obese patients. The primary objective of this study was to characterize and compare the pharmacokinetics (PK) of telavancin across four body size groups: normal to overweight and obesity classes I, II, and III. Healthy adult subjects (n=32) received a single, weight-stratified, fixed dose of 500 mg (n=4), 750 mg (n=8) or 1000 mg (n=20) of telavancin. Noncompartmental PK analyses revealed subjects with body mass index (BMI) ≥ 40 kg/m2 had a higher volume of distribution (16...
January 8, 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29301371/the-sodium-glucose-cotransporter-2-inhibitor-dapagliflozin-prevents-renal-and-liver-disease-in-western-diet-induced-obesity-mice
#15
Dong Wang, Yuhuan Luo, Xiaoxin Wang, David J Orlicky, Komuraiah Myakala, Pengyuan Yang, Moshe Levi
Obesity and obesity related kidney and liver disease have become more prevalent over the past few decades, especially in the western world. Sodium-glucose cotransporter 2 (SGLT2) inhibitors are a new class of antidiabetic agents with promising effects on cardiovascular and renal function. Given SGLT2 inhibitors exert both anti-diabetic and anti-obesity effects by promoting urinary excretion of glucose and subsequent caloric loss, we investigated the effect of the highly selective renal SGLT2 inhibitor dapagliflozin in mice with Western diet (WD) induced obesity...
January 3, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29288787/robotic-appendiceal-interposition-with-right-lower-pole-calycostomy-downward-nephropexy-and-psoas-hitch-for-the-management-of-an-iatrogenic-near-complete-ureteral-avulsion
#16
Martus Gn, Ziho Lee, David Strauss, Daniel Eun
Although iatrogenic ureteral injuries are rare, they have potentially devastating consequences for both patients and physicians, and their management remains challenging. We report a case of a 51-year-old morbidly obese (BMI=63) female who suffered an iatrogenic 15 centimeter right ureteral avulsion during hysteroscopic biopsy. Preoperative antegrade and retrograde pyelograms demonstrated no true renal pelvis and a 3 centimeter blind-ending distal ureteral stump. The patient underwent a right robotic downward nephropexy, psoas hitch, lower pole calycostomy and 11 cm appendiceal interposition...
December 27, 2017: Urology
https://www.readbyqxmd.com/read/29247554/diabetes-and-chronic-kidney-disease-an-increasingly-common-multi-morbid-disease-in-need-of-a-paradigm-shift-in-care
#17
REVIEW
P H Winocour
Diabetes is considered the commonest cause of end-stage renal disease. The increasing incidence of obesity and an ageing population, together, will lead to a greater number of people with diabetes associated with chronic kidney disease that could either be secondary to diabetic nephropathy or of different aetiology. Ageing and obesity influence approaches to the management of diabetes and accurate assessment of kidney disease. People with diabetes and chronic kidney disease consume a disproportionate component of expenditure on medical care...
December 16, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/29246788/alteration-of-connexin43-expression-in-a-rat-model-of-obesity-related-glomerulopathy
#18
Yongli Zhao, Guohua Li, Yuchuan Wang, Zhengjuan Liu
It is accepted that alteration of connexin43 (Cx43) expression in glomeruli is a common pathological response in several forms of kidney diseases. To date, however the change of the Cx43 expression in obesity-related glomerulopathy (ORG) has not been reported. In this study, the alteration of Cx43 expression in the glomeruli of rat with ORG was defined. Five-week-old rats were fed with high-fat diet for 18weeks to establish the ORG model, then the histological change of glomeruli, the foot process effacement of podocyte, the markers for podocyte injury (nephrin,podocin and WT1) and Cx43 expression in glomeruli were examined respectively...
December 12, 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29241180/high-mobility-group-box1-inhibitor-glycyrrhizic-acid-attenuates-kidney-injury-in-streptozotocin-induced-diabetic-rats
#19
Hong Zhang, Ru Zhang, Juan Chen, Min Shi, Wei Li, Xiangcheng Zhang
BACKGROUND/AIMS: High mobility group box 1 (HMGB1) is an important mediator of the inflammatory response. It has been implicated in the pathogenesis of autoimmune diseases, atherosclerosis, and obesity. However, the effects of HMGB1 on diabetic nephropathy remain unclear. Here, we investigated the potential roles and mechanisms of an HMGB1 inhibitor, glycyrrhizic acid (GA), in renal injury with the streptozotocin (STZ)-induced rat model. METHODS: The diabetic rat was generated by intraperitoneal injection of STZ and then treated with the HMGB1 inhibitor GA or saline for 8 weeks...
November 15, 2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29237999/the-relationships-among-hyperuricemia-body-mass-index-and-impaired-renal-function-in-type-2-diabetic-patients
#20
Yongmei Li, Xing Fan, Chunjun Li, Xinyue Zhi, Liyuan Peng, Hongling Han, Bei Sun
Chronic kidney disease (CKD) is a common chronic microvascular complication and the major cause of death in diabetic patients. This study was conceived to explore the possible mechanisms of how hyperuricemia and obesity contribute to renal function impairment in type 2 diabetic (T2DM) patients. A cross-sectional study in 609 participants recruited from a T2DM population in North China was conducted. The multiplicative interaction between body mass index (BMI) and uric acid (UA) level was assessed using an interaction term in a logistic regression analysis...
December 13, 2017: Endocrine Journal
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