keyword
https://read.qxmd.com/read/38522954/the-association-between-monocyte-to-high-density-lipoprotein-cholesterol-ratio-and-chronic-kidney-disease-in-a-chinese-adult-population-a-cross-sectional-study
#1
JOURNAL ARTICLE
Lingling Xu, Dongling Li, Zongwei Song, Jin Liu, Yang Zhou, Junwei Yang, Ping Wen
BACKGROUND: Monocyte to high-density lipoprotein cholesterol ratio (MHR) was confirmed as a novel inflammatory marker and strongly associated with the risk of several diseases. This study aimed to investigate the relationship between MHR and chronic kidney disease (CKD) in a Chinese adult population. METHODS: In this cross-sectional study, 232,775 community-dwelling adults in Binhai who completed health checkups in 2021 were enrolled. Participants were categorized based on the MHR quartiles...
December 2024: Renal Failure
https://read.qxmd.com/read/38522953/recent-advances-in-the-application-of-mendelian-randomization-to-chronic-kidney-disease
#2
REVIEW
Chaofan Wen, Lanlan Chen, Dan Jia, Ziqi Liu, Yidan Lin, Guan Liu, Shuo Zhang, Baoshan Gao
OBJECTIVE: Chronic kidney disease (CKD) is a condition influenced by both genetic and environmental factors and has been a focus of extensive research. Utilizing Mendelian randomization, researchers have begun to untangle the complex causal relationships underlying CKD. This review delves into the advances and challenges in the application of MR in the field of nephrology, shifting from a mere summary of its principles and limitations to a more nuanced exploration of its contributions to our understanding of CKD...
December 2024: Renal Failure
https://read.qxmd.com/read/38511219/parental-obesity-predisposes-offspring-to-kidney-dysfunction-and-increased-susceptibility-to-ischemia-reperfusion-injury-in-a-sex-dependent-manner
#3
JOURNAL ARTICLE
Jussara M do Carmo, John E Hall, Xuemei Dai, Nikaela Aitken, Kylie Larson, Emilio M Luna-Suarez, Zhen Wang, Ana C M Omoto, Alan Mouton, Xuan Li, Luzia N S Furukawa, Viktoria Woronik, Alexandre A da Silva
Although obesity is recognized as a risk factor for cardiorenal and metabolic diseases, the impact of parental obesity on the susceptibility of their offspring to renal injury at adulthood is unknown. We examined the impact of parental obesity on offspring kidney function, morphology, and markers of kidney damage after acute kidney injury (AKI). Offspring from normal (N) diet-fed C57BL/6J parents were fed either N (NN) or a high fat (H) diet (NH) from weaning until adulthood. Offspring from obese H diet-fed parents were fed N (HN) or H diet (HH) after weaning...
March 21, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38505538/autophagy-pyroptosis-and-ferroptosis-are-rising-stars-in-the-pathogenesis-of-diabetic-nephropathy
#4
REVIEW
Xiudan Li, Lifeng Gao, Xuyang Li, Jingdong Xia, Yurong Pan, Chunying Bai
Diabetic nephropathy (DN) is one of the most common microvascular complications in diabetes and can potentially develop into end-stage renal disease. Its pathogenesis is complex and not fully understood. Podocytes, glomerular endothelial cells (GECs), glomerular mesangial cells (GMCs) and renal tubular epithelial cells (TECs) play important roles in the normal function of glomerulus and renal tubules, and their injury is involved in the progression of DN. Although our understanding of the mechanisms leading to DN has substantially improved, we still need to find more effective therapeutic targets...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38483544/pharmacokinetics-of-polymyxin-b-in-different-populations-a-systematic-review
#5
REVIEW
Xing Wang, Wenqiang Xiong, Maolian Zhong, Yan Liu, Yuqing Xiong, Xiaoyi Yi, Xiaosong Wang, Hong Zhang
BACKGROUND AND OBJECTIVES: Despite being clinically utilized for the treatment of infections, the limited therapeutic range of polymyxin B (PMB), along with considerable interpatient variability in its pharmacokinetics and frequent occurrence of acute kidney injury, has significantly hindered its widespread utilization. Recent research on the population pharmacokinetics of PMB has provided valuable insights. This study aims to review relevant literature to establish a theoretical foundation for individualized clinical management...
March 14, 2024: European Journal of Clinical Pharmacology
https://read.qxmd.com/read/38480496/obesity-is-associated-with-improved-early-survival-but-increased-late-mortality-in-surgical-patients-with-sepsis-a-propensity-matched-analysis
#6
JOURNAL ARTICLE
Anahita Jalilvand, Megan Ireland, Courtney Collins, Whitney Kellett, Scott Strassel, Robert Tamer, Wendy Wahl, Jon Wisler
INTRODUCTION: While obesity is a risk factor for post-operative complications, its impact following sepsis is unclear. The primary objective of this study was to evaluate the association between obesity and mortality following admission to the surgical ICU (SICU) with sepsis. METHODS: We conducted a single center retrospective review of SICU patients grouped into obese (n = 766, BMI ≥30 kg/m2) and non-obese (n = 574, BMI 18-29.9 kg/m2) cohorts. Applying 1:1 propensity matching for age, sex, comorbidities, SOFA, and transfer status, demographic data, comorbidities, and sepsis presentation were compared between groups...
March 14, 2024: Journal of Trauma and Acute Care Surgery
https://read.qxmd.com/read/38474819/microrna-expression-profile-in-obesity-induced-kidney-disease-driven-by-high-fat-diet-in-mice
#7
JOURNAL ARTICLE
Àuria Eritja, Maite Caus, Thalia Belmonte, David de Gonzalo-Calvo, Alicia García-Carrasco, Ana Martinez, Montserrat Martínez, Milica Bozic
Obesity is one of the main causes of chronic kidney disease; however, the precise molecular mechanisms leading to the onset of kidney injury and dysfunction in obesity-associated nephropathy remain unclear. The present study aimed to unveil the kidney microRNA (miRNA) expression profile in a model of obesity-induced kidney disease in C57BL/6J mice using next-generation sequencing (NGS) analysis. High-fat diet (HFD)-induced obesity led to notable structural alterations in tubular and glomerular regions of the kidney, increased renal expression of proinflammatory and profibrotic genes, as well as an elevated renal expression of genes involved in cellular lipid metabolism...
February 28, 2024: Nutrients
https://read.qxmd.com/read/38469667/gut-microbiota-in-the-association-between-obesity-and-kidney-function-decline-a-metagenomics-based-study-in-a-rat-model
#8
JOURNAL ARTICLE
Akehu Alemasi, Lijiang Gu, Yilun Zhou
OBJECTIVES: Obesity can induce dysbiosis in the gut microbiota and is considered a separate risk factor for kidney function decline. Nonetheless, the precise function of intestinal microorganisms in facilitating the connection between obesity and kidney function decline remains uncertain. Hence, the objective of this study was to investigate the alterations in the gut microbiota composition that take place during obesity and their correlations with renal function utilizing a rat model...
December 2024: Renal Failure
https://read.qxmd.com/read/38460576/red-ginseng-ameliorates-lipotoxicity-induced-renal-fibrosis-in-hyperuricemia-mice
#9
JOURNAL ARTICLE
Ying-Ling Zhang, Si-Min Chen, Yi-Jie Song, Ariful Islam, Pei-Li Rao, Meng-Jie Zhu, Wen-Yi Gu, Yu Xu, Hong-Xi Xu
ETHNOPHARMACOLOGICAL RELEVANCE: Chronic kidney disease can be caused by numerous diseases including obesity and hyperuricemia (HUA). Obesity may exacerbate the renal injury caused by HUA. Red ginseng, a steamed products of Panax ginseng Meyer root, is known for its remarkable efficacy in improving metabolic syndrome, such as maintaining lipid metabolic balance. However, the role of red ginseng on hyperuricemia-induced renal injury in obese cases remains unclear. AIM OF THE STUDY: This study aimed to investigate the action of red ginseng extract (RGE) on lipotoxicity-induced renal injury in HUA mice...
March 7, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38445367/fto-attenuates-tnf-%C3%AE-induced-damage-of-proximal-tubular-epithelial-cells-in-acute-pancreatitis-induced-acute-kidney-injury-via-targeting-aqp3-in-an-n6-methyladenosine-dependent-manner
#10
JOURNAL ARTICLE
Xinghui Li, Qi Liang, Lu Liu, Shujun Chen, Yong Li, Yu Pu
BACKGROUND: Acute kidney injury (AKI) is a frequent complication of severe acute pancreatitis (SAP). Previous investigations have revealed the involvement of FTO alpha-ketoglutarate-dependent dioxygenase (FTO) and aquaporin 3 (AQP3) in AKI. Therefore, the aim of this study is to explore the association of FTO and AQP3 on proximal tubular epithelial cell damage in SAP-induced AKI. METHODS: An in-vitro AKI model was established in human proximal tubular epithelial cells (PTECs) HK-2 via tumor necrosis factor-α (TNF-α) induction (20 ng/mL), after which FTO and AQP3 expression was manipulated and quantified by quantitative real-time PCR and Western blotting...
December 2024: Renal Failure
https://read.qxmd.com/read/38427925/obesity-related-glomerulopathy-recent-advances-in-inflammatory-mechanisms-and-related-treatments
#11
JOURNAL ARTICLE
Yucan Guan, Xianping Wei, Jicui Li, Yuexin Zhu, Ping Luo, Manyu Luo
Obesity-related glomerulopathy (ORG), which is an obesity-triggered kidney damage, has become a significant threat to human health. Several studies have recently highlighted the critical role of inflammation in ORG development. Additionally, excess adipose tissue and adipocytes in patients with obesity produce various inflammatory factors that cause systemic low-grade inflammation with consequent damage to vascular endothelial cells, exacerbating glomerular injury. Therefore, we conducted a comprehensive review of ORG and addressed the critical role of obesity-induced chronic inflammation in ORG pathogenesis and progression, which leads to tubular damage and proteinuria, ultimately impairing renal function...
March 1, 2024: Journal of Leukocyte Biology
https://read.qxmd.com/read/38420674/podocytes-from-hypertensive-and-obese-mice-acquire-an-inflammatory-senescent-and-aged-phenotype
#12
JOURNAL ARTICLE
Sierra R McKinzie, Natalya Kaverina, Robert Allen Schweickart, Christopher Chaney, Diana G Eng, Beatriz Maria Veloso Pereira, Bryan Kestenbaum, Jeffrey W Pippin, Oliver Wessely, Stuart J Shankland
Patients with hypertension or obesity can develop glomerular dysfunction characterized by injury and depletion of podocytes. To better understand the molecular processes involved, young mice were treated with either deoxycorticosterone acetate (DOCA) or fed a high-fat diet (HFD) to induce hypertension or obesity, respectively. The transcriptional changes associated with these phenotypes were measured by unbiased bulk mRNA-sequencing of isolated podocytes from experimental models and their respective controls...
February 29, 2024: American Journal of Physiology. Renal Physiology
https://read.qxmd.com/read/38414866/the-expression-of-mir-377-3p-in-patients-with-dkd-and-the-regulatory-mechanism-of-mir-377-3p-on-the-inflammatory-response-of-hk-2-cells-through-tgf-%C3%AE
#13
JOURNAL ARTICLE
Chenhao Xing, Yamin Lu, Guangxia Liu, Fang Chen, Zhan Hou, Yiwen Zhang
OBJECTIVE: The purpose of the study was to investigate the expression levels and correlation of inflammatory factors such as miR-377-3p and TGF-β in patients with diabetic kidney disease (DKD), and to investigate the regulatory mechanism of transfection of miR-377-3p on the inflammatory response of HK-2 cell induced by high glucose. METHODS: According to UACR, patients were divided into normal albuminuria group (Con, n = 29), microalbuminuria group (Micro, n = 31) and macroalbuminuria group (Macro, n = 30), analyzed the correlation and influencing factors between DKD and inflammatory factor...
2024: Diabetes, Metabolic Syndrome and Obesity
https://read.qxmd.com/read/38396260/long-term-protective-effects-and-mechanisms-of-gastric-bypass-surgery-on-the-kidneys-in-hypertensive-obese-rat
#14
JOURNAL ARTICLE
Yuan Zhang, Xiangxin Kong, Ke Song, Ming He, Yin Xian, Xing Xie, Junming Cheng, Rubing Bai, Yixing Ren
OBJECTIVE: Investigate the long-term protective effects of gastric bypass surgery on the kidneys of hypertensive obese rats to better understand the role of gastric bypass surgery in preventing renal injury in humans with hypertension and obesity. METHODS: Compare 6-week-old spontaneously hypertensive rats, including 30 Roux-en-Y gastric bypass (RYGB) and 30 sham operations. Body weight and blood pressure were monitored before and up to 12 months after the operation...
February 23, 2024: Obesity Surgery
https://read.qxmd.com/read/38390733/aerobic-exercise-attenuates-high-fat-diet-induced-renal-injury-through-kidney-metabolite-modulation-in-mice
#15
JOURNAL ARTICLE
Yingzhe Xiong, Yisheng Luan, Lingfeng Yuan, Weihao Hong, Bin Wang, Hua Zhao, Bing Zhang
PURPOSE: To investigate the preventive effect of aerobic exercise on renal damage caused by obesity. METHODS: The mice in the Control (Con) and Control + Exercise (Con + Ex) groups received a standard chow diet for the 21-week duration of the study, while the High-fat diet (HFD) group and High-fat diet + Exercise (HFD + Ex) group were fed an HFD. Mice were acclimated to the laboratory for 1 week, given 12 weeks of being on their respective diets, and then the Con + Ex and HFD + Ex groups were subjected to moderate intensity aerobic treadmill running 45 min/day, 5 days/week for 8 weeks...
December 2024: Renal Failure
https://read.qxmd.com/read/38364742/bicyclol-alleviates-obesity-induced-renal-injury-by-inhibiting-jnk-and-nf-%C3%AE%C2%BAb-mediated-inflammation
#16
JOURNAL ARTICLE
Lingxi Zhang, Jiong Wang, Tingxin Xu, Yue Luo, Zhaohong Cai, Yongsheng Jiang, Tianyang Jin, Hongdan Bao, Yi Wang
Obesity is recognized as a major risk factor for chronic kidney disease (CKD), which is accompanied by increased renal lipid build-up, fibrosis, inflammation, apoptosis and pyroptosis. Bicyclol (BIC), a Chinese marketed hepatoprotective drug, has shown excellent anti-inflammatory, anti-fibrosis, anti-apoptotic, and lipid regulation effects in different animal models. In this study, we explored the role and mechanism of BIC in high-fat diet (HFD)-induced obesity-related nephropathy. Mice were fed with HFD for 24 weeks to develop obesity-related nephropathy, while mice in the BIC administration group were treated with BIC (50 mg/kg or 100 mg/kg, once every two days) at the last 12 weeks...
February 15, 2024: International Immunopharmacology
https://read.qxmd.com/read/38353216/early-renal-denervation-attenuates-cardiac-dysfunction-in-heart-failure-with-preserved-ejection-fraction
#17
JOURNAL ARTICLE
Jake E Doiron, Zhen Li, Xiaoman Yu, Kyle B LaPenna, Heather Quiriarte, Timothy D Allerton, Kashyap Koul, Andrew Malek, Sanjiv J Shah, Thomas E Sharp, Traci T Goodchild, Daniel R Kapusta, David J Lefer
BACKGROUND: The renal sympathetic nervous system modulates systemic blood pressure, cardiac performance, and renal function. Pathological increases in renal sympathetic nerve activity contribute to the pathogenesis of heart failure with preserved ejection fraction (HFpEF). We investigated the effects of renal sympathetic denervation performed at early or late stages of HFpEF progression. METHODS AND RESULTS: Male ZSF1 obese rats were subjected to radiofrequency renal denervation (RF-RDN) or sham procedure at either 8 weeks or 20 weeks of age and assessed for cardiovascular function, exercise capacity, and cardiorenal fibrosis...
February 14, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38344236/relationship-between-addictions-and-obesity-physical-activity-and-vascular-aging-in-young-adults-eva-adic-study-a-research-protocol-of-a-cross-sectional-study
#18
JOURNAL ARTICLE
Sara Vicente-Gabriel, Cristina Lugones-Sánchez, Olaya Tamayo-Morales, Alberto Vicente Prieto, Susana González-Sánchez, Sandra Conde Martín, Marta Gómez-Sánchez, Emiliano Rodríguez-Sánchez, Luis García-Ortiz, Leticia Gómez-Sánchez, Manuel A Gómez-Marcos
BACKGROUND: Behavioral and substance addictions are prevalent health problems that, alongside obesity, are linked to reduced physical activity and increased sedentary time. Similarly, arterial stiffness and vascular aging are processes that begin gradually at an early age and are closely associated with morbidity and mortality from cardiovascular diseases. The main objective of this study is to analyze how addictions are related to obesity and body fat distribution, physical activity, sedentary time, arterial stiffness and vascular aging, as well as sleep quality, cognitive function and gender differences in young adults aged between 18 and 34 years...
2024: Frontiers in Public Health
https://read.qxmd.com/read/38341277/global-epidemiology-of-kidney-cancer
#19
JOURNAL ARTICLE
Luigi Cirillo, Samantha Innocenti, Francesca Becherucci
Kidney cancer (KC) is a disease with a rising worldwide incidence estimated at 400 000 new cases annually, and a worldwide mortality rate approaching 175 000 deaths per year. Current projections suggest incidence continuing to increase over the next decade, thus emphasizing the urgency of addressing this significant global health trend. Despite the overall increases in incidence and mortality, striking social disparities are evident. Low- and middle-income countries bear a disproportionate burden of the disease, with higher mortality rates and later-stage diagnoses, underscoring the critical role of socioeconomic factors in disease prevalence and outcomes...
February 10, 2024: Nephrology, Dialysis, Transplantation
https://read.qxmd.com/read/38341135/glycoprotein-acetyls-associate-with-intraglomerular-hemodynamic-dysfunction-albuminuria-central-adiposity-and-insulin-resistance-in-youth-with-type-1-diabetes
#20
JOURNAL ARTICLE
Alyssa Caldwell McGee, Trenton Reinicke, Diego Carrasco, Jesse Goodrich, Meda E Pavkov, Daniel van Raalte, Carissa Birznieks, Robert G Nelson, Kristen J Nadeau, Ye Ji Choi, Tim Vigers, Laura Pyle, Ian de Boer, Petter Bjornstad, Kalie L Tommerdahl
AIMS: Glycoprotein acetyls (GlycA) is a biomarker of systemic inflammation and cardiovascular disease, yet little is known about its role in type 1 diabetes (T1D). We examined the associations among GlycA, central adiposity, insulin resistance, and early kidney injury in youth with T1D. METHODS: Glomerular filtration rate (GFR) and renal plasma flow (RPF) by iohexol and p-aminohippurate clearance, urine albumin-to-creatinine ratio (UACR), central adiposity by DXA, and estimated insulin sensitivity were assessed in fifty youth with T1D (16±3...
February 7, 2024: Canadian Journal of Diabetes
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