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https://www.readbyqxmd.com/read/29752597/the-higher-prevalence-of-developmental-defects-of-enamel-in-the-dioxin-affected-region-than-non-dioxin-affected-region-result-from-a-cross-sectional-study-in-vietnam
#1
Vo Truong Nhu Ngoc, Le Thi Huong, Bui Van Nhon, Ngo Thi Minh Tan, Pham Van Thuc, Vo Thi Thu Hien, Truong Manh Dung, Ngo Van Toan, Le Quynh Anh, Le Hoang Son, Thien Chu-Dinh, Dinh-Toi Chu
Developmental defects of enamel (DDE) are induced and regulated by several factors including genetics and the environment. There is evidence showing that dioxin in polluted areas has a strong effect on the health and development of teeth. However, there has been no study on DDE in the dioxin-affected regions in Vietnam. To identify the effect of dioxin on the prevalence of DDE in studied areas in Vietnam, a cross-sectional study was conducted in 2200 adults in the A Luoi district in the Thua Thien Hue province (the dioxin-affected region) and in the Kim Bang district in the Ha Nam province (dioxin-unaffected region) in 2015...
May 11, 2018: Odontology
https://www.readbyqxmd.com/read/29738624/saccharomyces-cerevisiae-mus81-mms4-and-rad52-can-cooperate-in-the-resolution-of-recombination-intermediates
#2
Huong Thi Thu Phung, Hoa Luong Hieu Nguyen, Sang Thanh Vo, Dung Hoang Nguyen, Minh Van Le
Mus81 is a well conserved DNA structure-specific endonuclease which belongs to the XPF/Rad1 family of proteins that are involved in DNA nucleotide excision repair. Mus81 forms a heterodimer with a non-catalytic subunit, Mms4 in Saccharomyces cerevisiae (Eme1/EME1 in Schizosaccharomyces pombe and mammals). Recent evidence shows that Mus81 functions redundantly with Sgs1, a member of the ubiquitous RecQ family of DNA helicases, to process toxic recombinant intermediates. In budding yeast, homologous recombination is regulated by the Rad52 epistasis group of proteins, including Rad52, which stimulates the main steps of DNA sequence-homology searching...
May 8, 2018: Yeast
https://www.readbyqxmd.com/read/29683344/a-new-sterol-from-the-vietnamese-marine-sponge-xestospongia-testudinaria-and-its-biological-activities
#3
Hien Minh Nguyen, Takuya Ito, Nwet Nwet Win, Hung Quoc Vo, Hoai Thi Nguyen, Hiroyuki Morita
A new sterol, langcosterol A (1), together with two known sterols 2 and 3, were isolated from the marine sponge Xestospongia testudinaria collected in Vietnam. Their chemical structures were elucidated on the basis of extensive spectroscopic analyses and comparisons with published data. The new compound 1 and the known compound 3 exhibited moderate cytotoxic activities against three human cancer cell lines (A549, lung cancer; MCF7, breast cancer; HeLa, cervical cancer) and a human normal cell line (WI-38 fibroblast), with IC50 values ranging from 29...
April 23, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29510687/bacterial-risk-factors-for-treatment-failure-and-relapse-among-patients-with-isoniazid-resistant-tuberculosis
#4
Phan Vuong Khac Thai, Dang Thi Minh Ha, Nguyen Thi Hanh, Jeremy Day, Sarah Dunstan, Nguyen Thi Quynh Nhu, Vo Sy Kiet, Nguyen Huu Lan, Nguyen Huy Dung, Nguyen Thi Ngoc Lan, Nguyen Thuong Thuong, Nguyen Ngoc Lan, Phạm Thị Thúy Liễu, Nguyễn Thị Hồng, Đào Công Điệp, Nguyễn Thị Kim Thanh, Nguyễn Văn Hội, Nguyễn Văn Nghĩa, Trương Ngọc Đại, Hoàng Quang Minh, Nguyễn Văn Thơm, Jeremy Farrar, Maxine Caws
BACKGROUND: Drug resistant tuberculosis (TB) is increasing in prevalence worldwide. Treatment failure and relapse is known to be high for patients with isoniazid resistant TB treated with standard first line regimens. However, risk factors for unfavourable outcomes and the optimal treatment regimen for isoniazid resistant TB are unknown. This cohort study was conducted when Vietnam used the eight month first line treatment regimen and examined risk factors for failure/relapse among patients with isoniazid resistant TB...
March 6, 2018: BMC Infectious Diseases
https://www.readbyqxmd.com/read/29495337/protective-effects-of-bacteriophages-against-aeromonas-hydrophila-species-causing-motile-aeromonas-septicemia-mas-in-striped-catfish
#5
Tuan Son Le, Thi Hien Nguyen, Hong Phuong Vo, Van Cuong Doan, Hong Loc Nguyen, Minh Trung Tran, Trong Tuan Tran, Paul C Southgate, D İpek Kurtböke
To determine the effectivity of bacteriophages in controlling the mass mortality of striped catfish ( Pangasianodon hypophthalmus ) due to infections caused by Aeromonas spp. in Vietnamese fish farms, bacteriophages against pathogenic Aeromonas hydrophila were isolated. A. hydrophila -phage 2 and A. hydrophila -phage 5 were successfully isolated from water samples from the Saigon River of Ho Chi Minh City, Vietnam. These phages, belonging to the Myoviridae family, were found to have broad activity spectra, even against the tested multiple-antibiotic-resistant Aeromonas isolates...
February 25, 2018: Antibiotics
https://www.readbyqxmd.com/read/29494554/molecular-epidemiology-of-helicobacter-pylori-infection-in-a-minor-ethnic-group-of-vietnam-a-multiethnic-population-based-study
#6
Tran Thanh Binh, Vo Phuoc Tuan, Ho Dang Quy Dung, Pham Huu Tung, Tran Dinh Tri, Ngo Phuong Minh Thuan, Le Quang Tam, Bui Chi Nam, Do Anh Giang, Phan Quoc Hoan, Tomohisa Uchida, Tran Thi Huyen Trang, Vu Van Khien, Yoshio Yamaoka
The Helicobacter pylori -induced burden of gastric cancer varies based on geographical regions and ethnic grouping. Vietnam is a multiethnic country with the highest incidence of gastric cancer in Southeast Asia, but previous studies focused only on the Kinh ethnic group. A population-based cross-sectional study was conducted using 494 volunteers (18-78 years old), from 13 ethnic groups in Daklak and Lao Cai provinces, Vietnam. H. pylori status was determined by multiple tests (rapid urease test, culture, histology, and serology)...
March 1, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29468899/markhacanasin-c-cycloartane-triterpenoid-from-the-leaves-of-markhamia-stipulata-var-canaense-v-s-dang
#7
Trong Nghia Ngo, Cong Thin Vo, Nguyen Kim Tuyen Pham, Nhat Minh Phan, Trong Dat Bui, Quoc Luan Ngo, Van Son Dang, Cong Luan Tran, Dinh Tri Mai, Tan Phat Nguyen
One new cycloartane triterpenoid, named markhacanasin C (1), together with three known triterpenoids, oleanolic acid (2), ursolic acid (3) and 6β,19α-dihydroxyursolic acid (4) were isolated by various chromatographic methods from the most cytotoxic fraction of the ethyl acetate extract of Markhamia stipulata var. canaense V.S. Dang leaves. Among them, 4 was reported for the first time from the genus Markhamia, while 2 and 3 were found for the first time from this species. Their structures were elucidated by IR, UV, HR-ESI-MS and NMR experiments...
February 22, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29402189/simplified-footprint-free-cas9-crispr-editing-of-cardiac-associated-genes-in-human-pluripotent-stem-cells
#8
Alexander Kondrashov, Minh Duc Hoang, James G W Smith, Jamie R Bhagwan, Gary Duncan, Diogo Mosqueira, Maria Barbadillo Munoz, Nguyen T N Vo, Chris Denning
Modeling disease with human pluripotent stem cells (hPSCs) is hindered because the impact on cell phenotype from genetic variability between individuals can be greater than from the pathogenic mutation. While "footprint-free" Cas9/CRISPR editing solves this issue, existing approaches are inefficient or lengthy. In this study, a simplified PiggyBac strategy shortened hPSC editing by 2 weeks and required one round of clonal expansion and genotyping rather than two, with similar efficiencies to the longer conventional process...
March 15, 2018: Stem Cells and Development
https://www.readbyqxmd.com/read/29363330/chemical-constituents-of-geum-urbanum-l-roots
#9
Quang Ton That, Truong Van Nguyen Thien, Huu Phuc Dang, Ngoc Le Hoan, Loan Kieu Thi Vo, Minh Huu Duc Nguyen, Nhan Truong Ngu, Thien S Nguyen, Poul Erik Hansen
A new dehydrodigallic acid derivative (1), along with 19 known compounds, including 6 phenolic derivatives, 2 steroids and 11 triterpenoids were isolated from the ethanol extract of the root of Geum urbanum. Herein, there is the first report of steroid and triterpene in Geum urbanum. The purified metabolites were characterised by NMR spectroscopic and mass spectrometric analyses. The identification of the known compounds (2-20) was based on the comparison of their NMR spectroscopic features with previously published data...
January 24, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29358416/retrospective-analysis-assessing-the-spatial-and-temporal-distribution-of-paediatric-acute-respiratory-tract-infections-in-ho-chi-minh-city-vietnam
#10
Nhan Thi Ho, Corinne Thompson, Le Nguyen Thanh Nhan, Hoang Minh Tu Van, Nguyen Thanh Dung, Phuc Tran My, Vo Minh Quang, Ngo Ngoc Quang Minh, Tran Anh Tuan, Nguyen Thanh Hung, Ha Manh Tuan, Nguyen Van Vinh Chau, Marcel Wolbers, Guy E Thwaites, Marc Choisy, Stephen Baker
BACKGROUND: Acute respiratory tract infections (ARIs) are the leading cause of morbidity and mortality in young children in low/middle-income countries. Using routine hospital data, we aimed to examine the spatial distribution, temporal trends and climatic risk factors of paediatric ARIs in Vietnam. METHODS: Data from hospitalised paediatric (<16 years) patients with ARIs residing in Ho Chi Minh City (HCMC) between 2005 and 2010 were retrieved from the two main Children's Hospitals and the Hospital for Tropical Diseases in HCMC...
January 21, 2018: BMJ Open
https://www.readbyqxmd.com/read/29306468/mid-term-outcomes-of-chronic-total-occlusion-percutaneous-coronary-intervention-with-subadventitial-vs-intraplaque-crossing-a-systematic-review-and-meta-analysis
#11
Aris Karatasakis, Barbara A Danek, Judit Karacsonyi, Lorenzo Azzalini, Mauro Carlino, Stéphane Rinfret, Minh Vo, Bavana V Rangan, M N Burke, Subhash Banerjee, Emmanouil S Brilakis
BACKGROUND: Some reports have demonstrated increased risk with subadventitial chronic total occlusion (CTO) crossing, whereas others suggest equipoise between subadventitial and intraplaque crossing techniques. We sought to clarify the effect of subadventitial lesion crossing on mid-term outcomes of CTO percutaneous coronary intervention (PCI). METHODS: We conducted a systematic review and meta-analysis of studies reporting post-discharge outcomes after CTO PCI performed via subadventitial vs...
February 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29283057/advanced-strategies-in-the-diagnosis-and-treatment-of-patients-with-coronary-artery-disease-and-heart-failure-when-heart-failure-causes-ischemia-and-angiotensin-converting-enzyme-inhibitor-and-betablockers-helps-in-diuresis
#12
Thach Nguyen, Nguyen Van Lanh, Vo Minh Viet, Lam Hoang Phuc, Trung N Pham, Khanh Duong, Luke Ashwin Lawrence, Vien T Truong, Gianluca Rigatelli
In the diagnosis and management of patients with coronary artery disease (CAD) and chronic left ventricular (LV) dysfunction or heart failure (HF), there are many uncertainties because of the non-specificity of the symptoms and signs of HF. Usually, severe CAD causes LV dysfunction. However, not rarely, LV dysfunction is the cause or aggravation of ischemia to many subsets of patients with or without CAD. In this article, the care of patients with CAD with LV dysfunction, along with the challenges of diagnosing asymptomatic HF and the criteria for monitoring success are presented...
December 27, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29279375/field-and-clinically-derived-estimates-of-wolbachia-mediated-blocking-of-dengue-virus-transmission-potential-in-aedes-aegypti-mosquitoes
#13
Lauren B Carrington, Bich Chau Nguyen Tran, Nhat Thanh Hoang Le, Tai Thi Hue Luong, Truong Thanh Nguyen, Phong Thanh Nguyen, Chau Van Vinh Nguyen, Huong Thi Cam Nguyen, Trung Tuan Vu, Long Thi Vo, Dui Thi Le, Nhu Tuyet Vu, Giang Thi Nguyen, Hung Quoc Luu, Anh Duc Dang, Timothy P Hurst, Scott L O'Neill, Vi Thuy Tran, Duong Thi Hue Kien, Nguyet Minh Nguyen, Marcel Wolbers, Bridget Wills, Cameron P Simmons
The w Mel strain of Wolbachia can reduce the permissiveness of Aedes aegypti mosquitoes to disseminated arboviral infections. Here, we report that w Mel-infected Ae. aegypti (Ho Chi Minh City background), when directly blood-fed on 141 viremic dengue patients, have lower dengue virus (DENV) transmission potential and have a longer extrinsic incubation period than their wild-type counterparts. The w Mel-infected mosquitoes that are field-reared have even greater relative resistance to DENV infection when fed on patient-derived viremic blood meals...
January 9, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29275223/antimicrobial-residues-and-resistance-against-critically-important-antimicrobials-in-non-typhoidal-salmonella-from-meat-sold-at-wet-markets-and-supermarkets-in-vietnam
#14
Nguyen Thi Nhung, Nguyen Thi Bich Van, Nguyen Van Cuong, Truong Thi Quy Duong, Tran Thi Nhat, Tran Thi Thu Hang, Nguyen Thi Hong Nhi, Bach Tuan Kiet, Vo Be Hien, Pham Thi Ngoc, James Campbell, Guy Thwaites, Juan Carrique-Mas
Excessive antimicrobial usage and deficiencies in hygiene in meat production systems may result in undesirable human health hazards, such as the presence of antimicrobial drug residues and non-typhoidal Salmonella (NTS), including antimicrobial resistant (AMR) NTS. Recently, Vietnam has witnessed the emergence of integrated intensive animal production systems, coexisting with more traditional, locally-sourced wet markets. To date no systematic studies have been carried out to compare health hazards in beef, pork and chicken in different production systems...
February 2, 2018: International Journal of Food Microbiology
https://www.readbyqxmd.com/read/29175481/purification-characterization-and-biological-effect-of-lectin-from-the-marine-sponge-stylissa-flexibilis-l%C3%A3-vi-1961
#15
Le Dinh Hung, Bui Minh Ly, Vo Thi Hao, Dinh Thanh Trung, Vo Thi Dieu Trang, Phan Thi Hoai Trinh, Ngo Thi Duy Ngoc, Thai Minh Quang
SFL, a lectin from the marine sponge Stylissa flexibilis was purified by cold ethanol precipitation followed by ion exchange chromatography on DEAE Sepharose column and Sephacryl S-200 gel filtration. SFL is a dimeric glycoprotein of 32kDa subunits linked by a disulfide bridge with a molecular mass of 64kDa by SDS-PAGE and 65kDa by Sephacryl S-200 gel filtration. SFL preferentially agglutinated enzyme treated human A erythrocytes. The activity of lectin was strongly inhibited by monosaccharide d-galactose and glycoproteins asialo-porcine stomach mucin and asialo-fetuin...
February 2018: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/29173183/a-comparison-of-fucoidan-conjugated-to-paclitaxel-and-curcumin-for-the-dual-delivery-of-cancer-therapeutic-agents
#16
Nam Hoang Phan, Thao Thanh Ly, Minh Nguyet Pham, Thinh Duc Luu, Toi Van Vo, Phuong Ha-Lien Tran, Thao Truong-Dinh Tran
The aim of this study was to develop and compare polymeric micelles of fucoidan, a sulfated polysaccharide, and hydrophobic drugs such as paclitaxel and curcumin. Paclitaxel and curcumin are both known for their medicinal properties, including anticancer efficacy. However, their very low water solubility, absorption and rapid metabolism leads to reduced bioavailability. To redress these problems and enhance anti-cancer therapeutics using fucoidan, polymeric micelles were synthesized from conjugates of fucoidan and hydrophobic drugs...
November 21, 2017: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/29144177/eudesmane-and-aromadendrane-sesquiterpenoids-from-the-vietnamese-soft-coral-sinularia-erecta
#17
Nguyen Thi Huong, Ninh Thi Ngoc, Nguyen Van Thanh, Nguyen Hai Dang, Nguyen Xuan Cuong, Nguyen Hoai Nam, Do Cong Thung, Ho Van The, Vo Sy Tuan, Phan Van Kiem, Chau Van Minh
Using various chromatographic separations, eight sesquiterpenoids (1-8), including one new compound 3β,5α-dihydroxyeudesma-4(15),11-diene (1), were isolated from the MeOH extract of the Vietnamese soft coral Sinularia erecta. The structure elucidation was confirmed by spectroscopic experiments including 1D and 2D NMR and HR-ESI-MS. The cytotoxic activities against three human cancer cell lines (A-549, HeLa and PANC-1) of all isolated compounds were evaluated by MTT-based colorimetric assays. Compound 1 exhibited selective cytotoxicity against the A549 cell line with IC50 of 14...
November 16, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29068125/novel-use-of-cutting-balloon-to-treat-subintimal-hematomas-during-chronic-total-occlusion-interventions
#18
Minh N Vo, Emmanouil S Brilakis, J Aaron Grantham
Contemporary chronic total occlusion (CTO) percutaneous coronary interventional (PCI) techniques are increasingly dependent upon dissection and reentry techniques (DARTs) especially for long occluded lesions. DARTs can result in compressive hematomas during CTO interventions and traditional treatment with balloon angioplasty and/or coronary stenting are often suboptimal and may extend the hematoma distally. We describe the novel use of a cutting balloon to "express" these compressive hematomas and restore antegrade coronary blood flow...
January 1, 2018: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/29035846/current-perspectives-and-practices-on-chronic-total-occlusion-percutaneous-coronary-interventions
#19
Siddharth M Patel, Rohan V Menon, M Nicolas Burke, Farouc A Jaffer, Robert W Yeh, Minh Vo, Dimitri Karmpaliotis, Lorenzo Azzalini, Mauro Carlino, Kambis Mashayekhi, Alfredo R Galassi, Stephane Rinfret, Stephen G Ellis, Mitul Patel, Bavana V Rangan, Aris Karatasakis, Barbara A Danek, Judit Karacsonyi, Erica Resendes, Subhash Banerjee, Emmanouil S Brilakis
OBJECTIVES: We sought to examine contemporary perspectives and practices on chronic total occlusion (CTO) percutaneous coronary intervention (PCI). BACKGROUND: The frequency and success of CTO-PCI have been increasing in recent years. METHODS: An online questionnaire was created and distributed to cardiologists within the United States and internationally. RESULTS: A total of 1149 responses were obtained. The United States (n = 845; 73...
February 2018: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/29030961/overproduction-of-mcl-pha-with-high-3-hydroxydecanoate-content
#20
Jie Gao, Minh T Vo, Juliana A Ramsay, Bruce A Ramsay
Methods of producing medium-chain-length poly-3-hydroxyalkanoate (mcl-PHA) with high content of the dominant subunit, 3-hydroxydecanoate (HD), were examined with an emphasis on a high yield of polymer from decanoic acid. High HD content was achieved by using a β-oxidation knockout mutant of Pseudomonas putida KT2440 (designated as P. putida DBA-F1) or by inhibiting β-oxidation with addition of acrylic acid (Aa) to wild type P. putida KT2440 in carbon-limited, fed-batch fermentations. At a substrate feed ratio of decanoic acid and acetic acid to glucose (DAA:G) of 6:4 g/g, P...
February 2018: Biotechnology and Bioengineering
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