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REVIEW
Gregory Condos, Kathleen E Kearney, William L Lombardi, Lorenzo Azzalini
Surgical bypass grafts are commonly used retrograde conduits to facilitate chronic total occlusion (CTO) percutaneous coronary intervention (PCI). While extensive experience exists using saphenous vein grafts as retrograde conduits in CTO PCI, information on the utilization of arterial grafts is more limited. In particular, the gastroepiploic artery (GEA) is a very uncommonly used arterial graft in contemporary bypass surgery and its role for retrograde CTO recanalization has received little study. We describe a case of right coronary artery CTO that was recanalized using the retrograde approach via a GEA graft to the posterior descending artery and highlight the specific challenges of this approach...
May 17, 2023: Cardiovascular Revascularization Medicine: Including Molecular Interventions
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JOURNAL ARTICLE
Kathryn L Taylor, Marguerite A Webster, Joanna G Philips, Julia M Whealan, Tania Lobo, Kimberly M Davis, Chavalia J Breece, Jennifer R Wheeley, Jack E Childs, Ariel Q Le, Randi M Williams, Irina G Veytsman, Chul Kim
As part of the NCI's Cancer Center Cessation (C3i) initiative, we initiated, expanded, and maintained an evidence-based tobacco treatment program at the Georgetown Lombardi Comprehensive Cancer Center. We present a quality improvement (QI) assessment of the implementation process and patient-level outcomes. At two hematology/oncology outpatient clinical sites, five oncology-based teams (clinical administrators, clinical staff, pharmacy, information technology, and tobacco treatment staff) developed implementation strategies for opt-out patient assessment and enrollment, centralized tobacco treatment, audit, feedback, and staff training...
March 28, 2023: Current Oncology
#23
JOURNAL ARTICLE
Barbara A Danek, Kathleen E Kearney, Christine J Chung, Zachary Steinberg, William L Lombardi, James M McCabe, Lorenzo Azzalini
Access to the arterial circulation and full anticoagulation carries a risk of serious bleeding during and after percutaneous coronary intervention. Important sources of bleeding include the arterial access site and coronary artery perforation. Prompt and effective management of hemorrhagic complications is an essential interventional skill. Protamine sulfate is well-known as a heparin reversal agent. Despite this, there is heterogeneity in the use of protamine during interventional procedures. While protamine is generally well-tolerated, it is associated with a risk of hypersensitivity reaction, including anaphylaxis, among others...
May 12, 2023: Catheterization and Cardiovascular Interventions
#24
JOURNAL ARTICLE
Anne I Roche, Samuel T Savitz, Sydney S Kelpin, Jocelyn Lebow, Nathaniel Lombardi, Olivia E Bogucki, Aaron A Kurtzhals, Maureen S Drews, Sarah T Trane, Jay-Sheree Allen, Mark D Williams, Craig N Sawchuk
PURPOSE: Many individuals with behavioral health challenges receive services in primary care, and integrated behavioral health (IBH) programs can help increase access to evidence-based interventions. IBH programs can benefit substantially from integrating standardized tracking databases that allow for the implementation of measurement-based care to evaluate patient-, clinician-, and practice-level outcomes. We describe the development and integration of Mayo Clinic's pediatric and adult primary care psychotherapy tracking database...
February 2023: Annals of Family Medicine
#25
JOURNAL ARTICLE
Adam C Salisbury, J Aaron Grantham, W Morris Brown, William L Ballard, Keith B Allen, Ajay J Kirtane, Michael Argenziano, Robert W Yeh, Kamal Khabbaz, John Lasala, Puja Kachroo, Dimitri Karmpaliotis, Jeffrey Moses, William L Lombardi, Karen Nugent, Ziad Ali, Kensey L Gosch, John A Spertus, David E Kandzari
BACKGROUND: Percutaneous coronary intervention (PCI) is increasingly used to revascularize patients ineligible for CABG, but few studies describe these patients and their outcomes. OBJECTIVES: This study sought to describe characteristics, utility of risk prediction, and outcomes of patients with left main or multivessel coronary artery disease ineligible for coronary bypass grafting (CABG). METHODS: Patients with complex coronary artery disease ineligible for CABG were enrolled in a prospective registry of medical therapy + PCI...
February 13, 2023: JACC. Cardiovascular Interventions
#26
JOURNAL ARTICLE
Dan D Nguyen, Kensey L Gosch, Rayan El-Zein, Paul S Chan, William L Lombardi, Dimitri Karmpaliotis, John A Spertus, R Michael Wyman, William J Nicholson, Jeffrey W Moses, J Aaron Grantham, Adam C Salisbury
Background Although chronic total occlusions (CTOs) are common in older adults, they are less likely to be offered CTO percutaneous coronary intervention for angina relief than younger adults. The health status impact of CTO percutaneous coronary intervention in adults aged ≥75 years has not been studied. We sought to compare technical success rates and angina-related health status outcomes at 12 months between adults aged ≥75 and <75 years in the OPEN-CTO (Outcomes, Patient Health Status, and Efficiency in Chronic Total Occlusion) registry...
January 31, 2023: Journal of the American Heart Association
#27
JOURNAL ARTICLE
William M Dawson, Kathryn L Shelley, Jordan M Fletcher, D Arne Scott, Lucia Lombardi, Guto G Rhys, Tania J LaGambina, Ulrike Obst, Antony J Burton, Jessica A Cross, George Davies, Freddie J O Martin, Francis J Wiseman, R Leo Brady, David Tew, Christopher W Wood, Derek N Woolfson
Differential sensing attempts to mimic the mammalian senses of smell and taste to identify analytes and complex mixtures. In place of hundreds of complex, membrane-bound G-protein coupled receptors, differential sensors employ arrays of small molecules. Here we show that arrays of computationally designed de novo peptides provide alternative synthetic receptors for differential sensing. We use self-assembling α-helical barrels (αHBs) with central channels that can be altered predictably to vary their sizes, shapes and chemistries...
January 24, 2023: Nature Communications
#28
JOURNAL ARTICLE
Lorenzo Azzalini, Taishi Hirai, Adam Salisbury, Kensey Gosch, James Sapontis, William J Nicholson, Dimitri Karmpaliotis, Jeffrey W Moses, Kathleen E Kearney, William L Lombardi, James Aaron Grantham
BACKGROUND: Risk stratification before chronic total occlusion (CTO) percutaneous coronary intervention (PCI) is important to inform procedural planning as well as patients and their families. We sought to externally validate the PROGRESS-CTO complication risk scores in the OPEN-CTO registry. METHODS: OPEN-CTO is a prospective registry of 1000 consecutive CTO PCIs performed at 12 experienced US centers using the hybrid algorithm. Endpoints of interest were in-hospital all-cause mortality, need for pericardiocentesis, acute myocardial infarction (MI), and major adverse cardiovascular events (MACE) (a composite of all-cause mortality, stroke, periprocedural MI, urgent repeat revascularization, and tamponade requiring pericardiocentesis)...
January 22, 2023: Catheterization and Cardiovascular Interventions
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JOURNAL ARTICLE
Lorenzo Azzalini, Nicolas Boudou, Alexandre Avran, Jesse Kane, William L Lombardi, Kathleen E Kearney, Mauro Carlino
BACKGROUND: There is scarce data on the outcomes of the Carlino technique for chronic total occlusion (CTO) percutaneous coronary intervention (PCI). We aimed to investigate the indications and outcomes of the Carlino technique as performed in the context of the retrograde approach. METHODS: We pooled CTO PCI cases where a retrograde Carlino technique was performed from high-volume operators at four centers. The Carlino technique was characterized according to its indication (achieving plaque/cap modification, clarifying microcatheter location within the vessel, resolving distal cap ambiguity) and was considered successful when it led to the desired outcome...
January 22, 2023: Catheterization and Cardiovascular Interventions
#30
JOURNAL ARTICLE
Bahadir Simsek, Peter Tajti, Mauro Carlino, Soledad Ojeda, Manuel Pan, Stephane Rinfret, Evangelia Vemmou, Spyridon Kostantinis, Ilias Nikolakopoulos, Judit Karacsonyi, Athanasios Rempakos, Joseph A Dens, Pierfrancesco Agostoni, Khaldoon Alaswad, Michael Megaly, Alexandre Avran, James W Choi, Farouc A Jaffer, Darshan Doshi, Dimitri Karmpaliotis, Jaikirshan J Khatri, Paul Knaapen, Alessio La Manna, James C Spratt, Masaki Tanabe, Simon Walsh, Olga C Mastrodemos, Salman Allana, Bavana V Rangan, Omer Goktekin, Sevket Gorgulu, Paul Poommipanit, Kathleen E Kearney, William L Lombardi, J Aaron Grantham, Kambis Mashayekhi, Emmanouil S Brilakis, Lorenzo Azzalini
BACKGROUND: Coronary artery perforation is one of the most feared and common complications of chronic total occlusion (CTO) percutaneous coronary intervention (PCI). METHODS: To assess the usefulness of the recently developed PROGRESS-CTO (NCT02061436) perforation risk score in independent cohorts. Individual patient-level data pooled analysis of three registries was performed. RESULTS: Of the 4566 patients who underwent CTO PCI at 25 centers, 196 (4...
January 8, 2023: Catheterization and Cardiovascular Interventions
#31
Minh N Vo, Emmanouil S Brilakis, William Lombardi
Chronic total occlusions with proximal cap ambiguity remains the most challenging to recanalize and are associated with higher failure rate. We describe the "power knuckle" technique, in which the subintimal space proximal to the proximal cap is safely entered with a knuckle wire supported by a microcatheter and an inflated balloon. The "power knuckle" can facilitate entry into the extraplaque space for subsequent antegrade dissection and re-entry.
January 8, 2023: Catheterization and Cardiovascular Interventions
#32
Arun Kalyanasundaram, Ravi S Hira, William L Lombardi
A novel device based CART technique (K14 technique) has been described with 2 case examples to illustrate the same. This CART has been performed after ADR and Reverse-CART were unsuccessful.
January 8, 2023: Catheterization and Cardiovascular Interventions
#33
JOURNAL ARTICLE
Lorenzo Azzalini, Gregory Condos, Kathleen E Kearney, William L Lombardi, James M McCabe
No abstract text is available yet for this article.
January 9, 2023: JACC. Cardiovascular Interventions
#34
JOURNAL ARTICLE
Bahadir Simsek, Peter Tajti, Mauro Carlino, Soledad Ojeda, Manuel Pan, Stephane Rinfret, Evangelia Vemmou, Spyridon Kostantinis, Ilias Nikolakopoulos, Judit Karacsonyi, Joseph A Dens, Pierfrancesco Agostoni, Khaldoon Alaswad, Michael Megaly, Alexandre Avran, James W Choi, Farouc A Jaffer, Darshan Doshi, Dimitri Karmpaliotis, Jaikirshan J Khatri, Paul Knaapen, Alessio La Manna, James C Spratt, Masaki Tanabe, Simon Walsh, Olga C Mastrodemos, Salman Allana, Athanasios Rempakos, Bavana V Rangan, Omer Goktekin, Sevket Gorgulu, Paul Poommipanit, Kathleen E Kearney, William L Lombardi, J Aaron Grantham, Kambis Mashayekhi, Emmanouil S Brilakis, Lorenzo Azzalini
BACKGROUND: Chronic total occlusion (CTO) percutaneous coronary intervention (PCI) is associated with a considerable risk of complications, and risk stratification is of utmost importance. AIMS: To assess the clinical usefulness of the recently developed PROGRESS-CTO (NCT02061436) complication risk scores in an independent cohort. METHODS: Individual patient data pooled analysis of 3 registries was performed. RESULTS: Of the 4569 patients who underwent CTO PCI, 102 (2...
December 21, 2022: International Journal of Cardiology
#35
JOURNAL ARTICLE
Bahadir Simsek, Mauro Carlino, Soledad Ojeda, Manuel Pan, Stephane Rinfret, Evangelia Vemmou, Spyridon Kostantinis, Ilias Nikolakopoulos, Judit Karacsonyi, Alexandre S Quadros, Joseph A Dens, Nidal Abi Rafeh, Pierfrancesco Agostoni, Khaldoon Alaswad, Alexandre Avran, Karlyse C Belli, James W Choi, Ahmed Elguindy, Farouc A Jaffer, Darshan Doshi, Dimitri Karmpaliotis, Jaikirshan J Khatri, Dmitrii Khelimskii, Paul Knaapen, Alessio La Manna, Oleg Krestyaninov, Pablo Lamelas, Lucio Padilla, Pedro Piccaro de Oliveira, James C Spratt, Masaki Tanabe, Simon Walsh, Omer Goktekin, Sevket Gorgulu, Olga C Mastrodemos, Salman Allana, Bavana V Rangan, Kathleen E Kearney, William L Lombardi, J Aaron Grantham, Taishi Hirai, Emmanouil S Brilakis, Lorenzo Azzalini
Coronary artery perforation is one of the most common and feared complications of chronic total occlusion (CTO) percutaneous coronary intervention (PCI). We evaluated the utility of the recently presented OPEN-CLEAN (Coronary artery bypass graft, Length of occlusion, Ejection fraction, Age, calcificatioN) perforation score in an independent multicenter CTO PCI dataset. Of the 2,270 patients who underwent CTO PCI at 7 centers, 150 (6.6%) suffered coronary artery perforation. Patients with perforations were older (69 ± 10 vs 65 ± 10, p <0...
November 30, 2022: American Journal of Cardiology
#36
REVIEW
Othman Al Musaimi, Lucia Lombardi, Daryl R Williams, Fernando Albericio
Peptides play an important role in many fields, including immunology, medical diagnostics, and drug discovery, due to their high specificity and positive safety profile. However, for their delivery as active pharmaceutical ingredients, delivery vectors, or diagnostic imaging molecules, they suffer from two serious shortcomings: their poor metabolic stability and short half-life. Major research efforts are being invested to tackle those drawbacks, where structural modifications and novel delivery tactics have been developed to boost their ability to reach their targets as fully functional species...
October 19, 2022: Pharmaceuticals
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JOURNAL ARTICLE
Nathan J Lee, Gerard Marciano, Varun Puvanesarajah, Paul J Park, William E Clifton, Kevin Kwan, Cole R Morrissette, Jaques L Williams, Michael Fields, Fthimnir M Hassan, Peter D Angevine, Christopher E Mandigo, Joseph M Lombardi, Zeeshan M Sardar, Ronald A Lehman, Lawrence G Lenke
OBJECTIVE: The purpose of this study was to determine the incidence, mechanism, and potential protective strategies for pelvic fixation failure (PFF) within 2 years after adult spinal deformity (ASD) surgery. METHODS: Data for ASD patients (age ≥ 18 years, minimum of six instrumented levels) with pelvic fixation (S2-alar-iliac [S2AI] and/or iliac screws) with a minimum 2-year follow-up were consecutively collected (2015-2019). Patients with prior pelvic fixation were excluded...
October 14, 2022: Journal of Neurosurgery. Spine
#38
JOURNAL ARTICLE
Kent Wallner, Kathleen E Kearney, Minsun Kim, Jasleen Tiwana, David Elison, Edward Y Kim, Upendra Parvathaneni, William L Lombardi, Mark L Phillips, Creighton Don
INTRODUCTION: One strategy to improve the effectiveness of intravascular brachytherapy (IVBT) is to study its failures. Previous investigations described mostly discrete, focal recurrences, typically at the proximal or distal edges of the irradiated segment after plain angioplasty or bare metal stents. We reviewed failure patterns of 30 unselected drug-eluting stent (DES) patients who had follow-up angiograms for recurrence within their IVBT-treated vessel. METHODS: Records of 53 unselected IVBT patients treated between 2016 and 2021 were reviewed...
September 13, 2022: Catheterization and Cardiovascular Interventions
#39
JOURNAL ARTICLE
Nathan J Lee, Paul J Park, Varun Puvanesarajah, William E Clifton, Kevin Kwan, Cole R Morrissette, Jaques L Williams, Michael W Fields, Eric Leung, Fthimnir M Hassan, Peter D Angevine, Christopher E Mandigo, Joseph M Lombardi, Zeeshan M Sardar, Ronald A Lehman, Lawrence G Lenke
OBJECTIVE: There is a paucity of literature on pelvic fixation failure after adult spine surgery in the early postoperative period. The purpose of this study was to determine the incidence of acute pelvic fixation failure in a large single-center study and to describe the lessons learned. METHODS: The authors performed a retrospective review of adult (≥ 18 years old) patients who underwent spinal fusion with pelvic fixation (iliac, S2-alar-iliac [S2AI] screws) at a single academic medical center between 2015 and 2020...
August 26, 2022: Journal of Neurosurgery. Spine
#40
JOURNAL ARTICLE
Othman Al Musaimi, Sophie V Morse, Lucia Lombardi, Simona Serban, Alessandra Basso, Daryl R Williams
Successful manual synthesis of the TD2.2 peptide acting as a blood-brain barrier shuttle was achieved. TD2.2 was successfully synthesised by sequential condensation of four protected peptide fragments on solid-phase settings, after several unsuccessful attempts using the stepwise approach. These fragments were chosen to minimize the number of demanding amino acids (in terms of coupling, Fmoc removal) in each fragment that are expected to hamper the overall synthetic process. Thus, the hydrophobic amino acids as well as Fmoc-Arg (Pbf)-OH were strategically spread over multiple fragments rather than having them congested in one fragment...
August 23, 2022: Journal of Peptide Science
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