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Mineral metabolism

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https://www.readbyqxmd.com/read/28087977/fibroblast-growth-factor-23-fgf23-in-untreated-nephrotic-syndrome
#1
Ashok Kumar Yadav, Raja Ramachandran, Abhinav Aggarwal, Vinod Kumar, Krishan Lal Gupta, Vivekanand Jha
AIM: Despite its importance in bone and cardiovascular disease in subjects with kidney disease, there is no data on fibroblast growth factor 23 (FGF23) perturbations in nephrotic syndrome. We evaluated FGF23 and markers of mineral bone metabolism in subjects with untreated NS. METHODS: In this cross-sectional study, we measured circulating levels of FGF23, 25-hydroxy vitamin D [25(OH)D], 1,25 di-hydroxy vitamin D [1,25(OH)2 D], serum albumin, serum calcium, phosphorus, creatinine and intact parathyroid hormone (iPTH) in 101 patients with adults onset NS and 40 healthy controls...
January 14, 2017: Nephrology
https://www.readbyqxmd.com/read/28087005/and-the-fat-lady-sings-about-phosphate-and-calcium
#2
Carsten A Wagner, Pedro H Imenez Silva, Isabel Rubio-Aliaga
Adipose tissue has been long recognized as secreting various endocrine factors. Emerging evidence demonstrates that adipokines play a role in modulating systemic mineral homeostasis through endocrine loops involving interleukin-6, leptin, and now also adiponectin, which all interact with FGF23 and vitamin D and thereby change the renal control of calcium and phosphate metabolism. Understanding these regulatory loops may shed light on a complex interorgan crosstalk controlling mineral homeostasis and its dysregulation in diseases associated with obesity...
February 2017: Kidney International
https://www.readbyqxmd.com/read/28081469/anti-osteoporotic-effects-of-an-antidepressant-tianeptine-on-ovariectomized-rats
#3
Osama A Alkhamees, Abdulaziz S Al-Roujayee, Hatem M Abuohashish, Mohammed M Ahmed
In the current investigation, the potential alleviating effects of tianeptine against bone loss induced in ovariectomized (OVX) rats was determined. Two weeks following a bilateral ovariectomy operation, tianeptine treatment (12.5 and 25mg/kg/twice/d) was initiated and continued for twenty-eight consecutive days. Changes in serum and urinary bone turnover biomarkers and osteoclastogenesis-inducing factors were estimated. The femoral bone mineral content was estimated using inductively-coupled-plasma mass spectrometry...
January 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28081333/bone-mineral-density-and-growth-in-children-with-coeliac-disease-on-a-gluten-free-diet
#4
Ceyda Tuna Kırsaçlıoğlu, Zarife Kuloğlu, Aydan Tanca, Nuriye Özlem Küçük, Zehra Aycan, Gönül Öcal, Arzu Ensari, Ayhan Gazi Kalaycı, Nurten Girgin
BACKGROUND/AIM: To evaluate changes in growth and bone metabolism during consumption of a gluten-free diet (GFD) in children with coeliac disease (CD). MATERIALS AND METHODS: Thirty-seven children with CD (mean age of 8.8 ± 4.6 years, 21 girls) were enrolled. Anthropometric measurements, bone mineral density (BMD) in lumbar 2-4 vertebrae, and serum alkaline phosphatase, calcium, and phosphorus levels at diagnosis and at follow-up were recorded. RESULTS: The mean follow-up period was 3...
December 20, 2016: Turkish Journal of Medical Sciences
https://www.readbyqxmd.com/read/28079119/interleukin-32-gamma-stimulates-bone-formation-by-increasing-mir-29a-in-osteoblastic-cells-and-prevents-the-development-of-osteoporosis
#5
Eun-Jin Lee, Sang-Min Kim, Bongkun Choi, Eun-Young Kim, Yeon-Ho Chung, Eun-Ju Lee, Bin Yoo, Chang-Keun Lee, Seokchan Hong, Beom-Jun Kim, Jung-Min Koh, Soo-Hyun Kim, Yong-Gil Kim, Eun-Ju Chang
Interleukin-32 gamma (IL-32γ) is a recently discovered cytokine that is elevated in inflamed tissues and contributes to pathogenic features of bone in human inflammatory rheumatic diseases. Nevertheless, the role of IL-32γ and its direct involvement in bone metabolism is unclear. We investigated the molecular mechanism of IL-32γ in bone remodeling and the hypothetical correlation between IL-32γ and disease activity in osteoporosis patients. Transgenic (TG) mice overexpressing human IL-32γ showed reduced bone loss with advancing age, increased bone formation, and high osteogenic capacity of osteoblast compared to wild-type (WT) mice through the upregulation of miR-29a, which caused a reduction of Dickkopf-1 (DKK1) expression...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28078791/effects-of-stem-cell-transplantation-on-bone-mineral-density-and-vitamin-d-status-in-children-with-thalassemia-major
#6
Dilek Gürlek Gökçebay, Namik Ozbek, Arzu Yazal Erdem, Vildan Culha, Nese Yarali, Pamir Isik, Zekai Avci, Fatih Azik, Fatma Demirel, Bahattin Tunc
HSCT is a curative treatment in TM, but conditioning and immunosuppressive treatment may affect bone metabolism. In this retrospective study, we aimed to compare BMD, vitamin D status, and growth in children with TM who underwent HSCT to those in children with TD TM. Twenty-three children with TM who underwent HSCT (mean age 7.1 years [1.03-14.7]) and 24 children with TD thalassemia (mean age 9.8 years [1.6-14]) were recruited. Lumbar spine BMD of TD thalassemia patients was higher than those in patients who had HSCT at both baseline and second-year assessments (P=...
January 12, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28078366/genetic-screening-of-wnt4-and-wnt5b-in-two-populations-with-deviating-bone-mineral-densities
#7
Gretl Hendrickx, Eveline Boudin, Ellen Steenackers, Torben Leo Nielsen, Marianne Andersen, Kim Brixen, Wim Van Hul
A role for WNT4 and WNT5B in bone metabolism was indicated by genome-wide association studies (GWAS) and a Wnt4 knockout mouse model. The aim of this study was therefore to replicate and further investigate the causality between genetic variation in WNT4 and WNT5B and deviating bone mineral density (BMD) values. A WNT4 and WNT5B mutation screening was performed in patients with craniotubular hyperostosis using Sanger sequencing. Here, no putative causal mutations were detected. Moreover, a high and low BMD cohort was selected from the Odense Androgen Study population for re-sequencing...
January 12, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/28075122/acetylene-fuels-tce-reductive-dechlorination-by-defined-dehalococcoides-pelobacter-consortia
#8
Xinwei Mao, Ronald S Oremland, Tong Liu, Sara Gushgari, Abigail Amanda Landers, Shaun M Baesman, Lisa Alvarez-Cohen
Acetylene (C2H2) can be generated in contaminated groundwater sites as a consequence of chemical degradation of trichloroethene (TCE) by in situ minerals, and C2H2 is known to inhibit bacterial dechlorination. In this study, we show that while high C2H2 (1.3 mM) concentrations reversibly inhibit reductive dechlorination of TCE by Dehalococcoides mccartyi isolates as well as enrichment cultures containing D. mccartyi sp., low C2H2 (0.4 mM) concentrations do not inhibit growth or metabolism of D. mccartyi. Co-cultures of Pelobacter SFB93, a C2H2-fermenting bacterium, with D...
January 11, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28074251/hyponatremia-and-fractures-should-hyponatremia-be-further-studied-as-a-potential-biochemical-risk-factor-to-be-included-in-frax-algorithms
#9
REVIEW
J C Ayus, T Bellido, A L Negri
The Fracture Risk Assessment Tool (FRAX®) was developed by the WHO Collaborating Centre for metabolic bone diseases to evaluate fracture risk of patients. It is based on patient models that integrate the risk associated with clinical variables and bone mineral density (BMD) at the femoral neck. The clinical risk factors included in FRAX were chosen to include only well-established and independent variables related to skeletal fracture risk. The FRAX tool has acquired worldwide acceptance despite having several limitations...
January 10, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28070461/transcriptome-analysis-of-the-oriental-melon-cucumis-melo-l-var-makuwa-during-fruit-development
#10
Ah-Young Shin, Yong-Min Kim, Namjin Koo, Su Min Lee, Seokhyeon Nahm, Suk-Yoon Kwon
BACKGROUND: The oriental melon (Cucumis melo L. var. makuwa) is one of the most important cultivated cucurbits grown widely in Korea, Japan, and northern China. It is cultivated because its fruit has a sweet aromatic flavor and is rich in soluble sugars, organic acids, minerals, and vitamins. In order to elucidate the genetic and molecular basis of the developmental changes that determine size, color, and sugar contents of the fruit, we performed de novo transcriptome sequencing to analyze the genes expressed during fruit development...
2017: PeerJ
https://www.readbyqxmd.com/read/28070325/comparative-study-on-proximate-functional-mineral-and-antinutrient-composition-of-fermented-defatted-and-protein-isolate-of-parkia-biglobosa-seed
#11
Bolajoko I Ogunyinka, Babatunji E Oyinloye, Foluso O Osunsanmi, Abidemi P Kappo, Andrew R Opoku
The use of plant-derived foods in the prevention, treatment, and management of metabolic diseases especially diabetes has gained prominence; this has been associated with their physicochemical properties. This study was conducted to compare the proximate, functional, mineral, and antinutrient composition of the fermented seeds, the defatted seeds, and the protein isolate from Parkia biglobosa seeds. The results showed that the fermented, defatted, and protein isolate varied in composition within the parameters studied...
January 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28070260/relationship-between-bone-density-and-biochemical-markers-of-bone-among-two-groups-taking-carbamazepine-and-sodium-valproate-for-epilepsy-in-comparison-with-healthy-individuals-in-yazd
#12
Abolghasem Rahimdel, Ali Dehghan, Mahboubeh Abolhassani Moghadam, Ali Mellat Ardekani
INTRODUCTION: Chronic antiepileptic therapy has been associated with metabolic bone diseases including osteomalacia and osteoporosis. The aim of this study was to determine frequency of changes in biochemical and bone mineral density (BMD) in adults receiving valproaic acid (VPA) & carbamazepine (CBZ). METHODS: In a cross sectional study evaluating adults (age 20-50 y) epileptic patients receiving valproic acid or carbamazepine for at least 2 years. This study was conducted from May 2014 to May 2015 in Shahid Sadoughi Hospital of Yazd University of Medical Science, Yazd, Iran...
November 2016: Electronic Physician
https://www.readbyqxmd.com/read/28069346/prevalence-and-severity-of-bone-loss-in-burned-patients
#13
Aria Partovi, Alireza Dabaghmanesh, Sharareh Roshanzamir
Often discovered late during the clinical course of burns, bone loss is widely accepted by clinicians as a de facto consequence of burn. Literature on this bone loss is limited and contradictory in details. More insight into the prevalence and magnitude of bone loss may facilitate its prevention. To this end, over a period of two years, we gathered a test group of 34 male patients with at least six-month-old thermal burns and a control group of 50 male members of similar age and geographical background as our test group...
January 6, 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28069090/effects-of-recombinant-human-growth-hormone-for-osteoporosis-systematic-review-and-meta-analysis
#14
Hayden F Atkinson, Rebecca F Moyer, Daniel Yacoub, Dexter Coughlin, Trevor B Birmingham
Our objective was to evaluate the efficacy of recombinant human growth hormone (GH) on bone mineral density (BMD) in persons age 50 and older, with normal pituitary function, with or at risk for developing osteoporosis. We systematically reviewed randomized clinical trials (RCTs), searching six databases, and conducted meta-analyses to examine GH effects on BMD of the lumbar spine and femoral neck. Data for fracture incidence, bone metabolism biomarkers, and adverse events were also extracted and analysed. Thirteen RCTs met the eligibility criteria...
January 10, 2017: Canadian Journal on Aging, la Revue Canadienne du Vieillissement
https://www.readbyqxmd.com/read/28067268/regional-adaptation-defines-sensitivity-to-future-ocean-acidification
#15
Piero Calosi, Sedercor Melatunan, Lucy M Turner, Yuri Artioli, Robert L Davidson, Jonathan J Byrne, Mark R Viant, Stephen Widdicombe, Simon D Rundle
Physiological responses to temperature are known to be a major determinant of species distributions and can dictate the sensitivity of populations to global warming. In contrast, little is known about how other major global change drivers, such as ocean acidification (OA), will shape species distributions in the future. Here, by integrating population genetics with experimental data for growth and mineralization, physiology and metabolomics, we demonstrate that the sensitivity of populations of the gastropod Littorina littorea to future OA is shaped by regional adaptation...
January 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28066993/developing-a-biomimetic-tooth-bud-model
#16
Elizabeth E Smith, Weibo Zhang, Nathan R Schiele, Ali Khademhosseini, Catherine K Kuo, Pamela C Yelick
A long-term goal is to bioengineer, fully functional, living teeth for regenerative medicine and dentistry applications. Biologically based replacement teeth would avoid insufficiencies of the currently used dental implants. Using natural tooth development as a guide, a model was fabricated using post-natal porcine dental epithelial (pDE), porcine dental mesenchymal (pDM) progenitor cells, and human umbilical vein endothelial cells (HUVEC) encapsulated within gelatin methacrylate (GelMA) hydrogels. Previous publications have shown that post-natal DE and DM cells seeded onto synthetic scaffolds exhibited mineralized tooth crowns composed of dentin and enamel...
January 8, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28065384/the-effects-of-fat-induced-obesity-on-bone-metabolism-in-rats
#17
Wei Li, Peng Xu, Cuizhe Wang, Xiaodan Ha, Yajuan Gu, Yan Wang, Jun Zhang, Jianxin Xie
OBJECTIVE: The aim of the current study was to investigate the effects of obesity, induced via a high-fat diet, on bone metabolism in rats. METHODS: Two hundred healthy Wistar male rats aged 4 weeks were fed a standard diet and a high-fat diet. At specific time points (week 0, 4, 6, 8, and 10), plasma was collected to determine the levels of glucose and lipid metabolism. Additionally, enzyme-linked immunoassays were performed to determine the plasma levels of adipocyte and bone metabolism factors...
January 3, 2017: Obesity Research & Clinical Practice
https://www.readbyqxmd.com/read/28065190/cholecalciferol-v-ergocalciferol-for-25-hydroxyvitamin-d-25-oh-d-repletion-in-chronic-kidney-disease-a-randomised-clinical-trial
#18
James B Wetmore, Cassandra Kimber, Jonathan D Mahnken, Jason R Stubbs
Patients with chronic kidney disease (CKD) demonstrate complex mineral metabolism derangements and a high prevalence of vitamin D deficiency. However, the optimal method of 25-hydroxyvitamin D (25(OH)D) repletion is unknown, and trials analysing the comparative efficacy of cholecalciferol and ergocalciferol in this population are lacking. We conducted a randomised clinical trial of cholecalciferol 1250μg (50 000 IU) weekly v. ergocalciferol 1250μg (50 000 IU) weekly for 12 weeks in forty-four non-dialysis-dependent patients with stage 3-5 CKD...
January 9, 2017: British Journal of Nutrition
https://www.readbyqxmd.com/read/28064444/phosphate-binders-and-targets-over-decades-do-we-have-it-right-now
#19
Morgan Marcuccilli, Michel Chonchol, Anna Jovanovich
In advanced renal disease, the kidney is unable to maintain phosphate balance due to decreased urinary excretion as well as the imbalance of the bone metabolic axis. It is well established that hyperphosphatemia is associated with increased cardiovascular events and mortality in patients with chronic kidney disease (CKD). However, there are no randomized controlled trials that demonstrate a clear benefit on hard outcomes in lowering serum phosphate levels to recommended targets in the CKD or dialysis population...
January 8, 2017: Seminars in Dialysis
https://www.readbyqxmd.com/read/28064096/high-glucose-induced-lif-suppresses-osteoblast-differentiation-via-regulating-stat3-socs3-signaling
#20
Changlu Liu, Dianming Jiang
High glucose (HG) is conceived to regulate bone metabolism in patients with diabetic mellitus (DM). In the present study, we examined the level of leukemia inhibitory factor (LIF), a pleiotropic cytokine in interleukin (IL)-6 family, in T2DM patients and investigated the regulation by HG on the induction of LIF/signal transducer and activator of transcription 3 (STAT3) signaling. Then we determined the regulation of HG and LIF on the osteoblast differentiation via measuring the ALP activity, matrix mineralization, and the expression of alkaline phosphatase (ALP), Runt-related transcription factor 2 (RUNX2), Osteocalcin (OCN) and osteopontin (OPN) in human osteoblast MG-63 cells...
January 5, 2017: Cytokine
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