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Celiac disease and autism

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https://www.readbyqxmd.com/read/27852289/serological-screening-for-celiac-disease-in-382-pre-schoolers-with-autism-spectrum-disorder
#1
Sara Calderoni, Elisa Santocchi, Teresa Del Bianco, Elena Brunori, Laura Caponi, Aldo Paolicchi, Francesca Fulceri, Margherita Prosperi, Antonio Narzisi, Angela Cosenza, Raffaella Tancredi, Filippo Muratori
BACKGROUND: Recent investigations suggest a possible common genetic background between Autism Spectrum Disorders (ASD) and Celiac Disease (CD). However, studies regarding this association are scarce and often limited by the small sample sizes and/or large heterogeneity among ASD groups in terms of demographic and clinical features. The present study aims to investigate the overall CD prevalence (biopsy proven-CD patients plus screening detected tTG and EMA positive cases) in a large population of pre-schoolers with ASD referred to a tertiary care University Hospital...
November 16, 2016: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/27833600/mucosal-prevalence-and-interactions-with-the-epithelium-indicate-commensalism-of-sutterella-spp
#2
Kaisa Hiippala, Veera Kainulainen, Marko Kalliomäki, Perttu Arkkila, Reetta Satokari
Sutterella species have been frequently associated with human diseases, such as autism, Down syndrome, and inflammatory bowel disease (IBD), but the impact of these bacteria on health still remains unclear. Especially the interactions of Sutterella spp. with the host are largely unknown, despite of the species being highly prevalent. In this study, we addressed the interaction of three known species of Sutterella with the intestinal epithelium and examined their adhesion properties, the effect on intestinal barrier function and the pro-inflammatory capacity in vitro...
2016: Frontiers in Microbiology
https://www.readbyqxmd.com/read/27824638/autism-spectrum-disorder-and-avoidant-restrictive-food-intake-disorder
#3
Jennifer Lucarelli, Demetra Pappas, Leah Welchons, Marilyn Augustyn
Kendra is a 4-year-old girl with autism spectrum disorder (ASD) who presents for follow-up of feeding problems to her pediatric clinician. She is an only child in a family where both parents are scientists. Feeding concerns date to infancy, when she was diagnosed with Gastroesophageal Reflux Disease (GERD) associated with persistent bottle refusal and the acceptance of few pureed foods. At 13 months, milk and peanut allergies were diagnosed. Following a feeding clinic evaluation at 24 months, she was prescribed a soy milk supplement and an H2 blocker...
November 4, 2016: Journal of Developmental and Behavioral Pediatrics: JDBP
https://www.readbyqxmd.com/read/27647538/mood-disorders-and-non-celiac-gluten-sensitivity
#4
Giovanni Casella, Roberta Pozzi, Marta Cicognetti, Francesco Bachetti, Gabriele Torti, Moris Cadei, Vincenzo Villanacci, Vittorio Baldini, Gabrio Bassotti
The association between gluten related disorders and psychiatric diseases has been firmly demonstrated. Non celiac gluten sensitivity (NCGS) is a syndrome diagnosed in patients responsive to gluten free diet after ruling out celiac disease and wheat allergy. The pathogenesis of neuro-psychiatric disorders in NCGS is unclear. An association between gluten and schizophrenia was described for the first time in 1950 by Bender et al. In the 50', Dicke noted that gluten free diet improved mood in celiac patients...
September 20, 2016: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/27621806/unexpected-improvement-in-core-autism-spectrum-disorder-symptoms-after-long-term-treatment-with-probiotics
#5
Enzo Grossi, Sara Melli, Delia Dunca, Vittorio Terruzzi
OBJECTIVES: Autism spectrum disorder is a neurodevelopmental condition that typically displays socio-communicative impairment as well as restricted stereotyped interests and activities, in which gastrointestinal disturbances are commonly reported. We report the case of a boy with Autism Spectrum Disorder (ASD) diagnosis, severe cognitive disability and celiac disease in which an unexpected improvement of autistic core symptoms was observed after four months of probiotic treatment. METHOD: The case study refers to a 12 years old boy with ASD and severe cognitive disability attending the Villa Santa Maria Institute in resident care since 2009...
2016: SAGE open medical case reports
https://www.readbyqxmd.com/read/27498299/gluten-intolerance-and-neurodevelopmental-disorders-is-nitric-oxide-the-common-biomarker-linking-these-conditions
#6
Keith Fluegge
Cruchet et al. attempt to tease out the myths and facts surrounding the growing popularity of certain dietary approaches in the management of neurodevelopmental disorders, like attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorders (ASDs). The authors identify a particular exclusionary-type approach that seeks to eliminate dietary gluten. Although the relationship between celiac disease (CD) and ADHD/ASD is not well established, a repeated clinical feature noted in CD is the elevated levels of nitric oxide in serum and urine...
2016: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/27356007/truths-myths-and-needs-of-special-diets-attention-deficit-hyperactivity-disorder-autism-non-celiac-gluten-sensitivity-and-vegetarianism
#7
Sylvia Cruchet, Yalda Lucero, Verónica Cornejo
Different dietary approaches have been attempted for the treatment of attention-deficit/hyperactivity disorder and autism, but only three of them have been subjected to clinical trials: education in healthy nutritional habits, supplementation and elimination diets. On the other hand, for multiple reasons, the number of people who adopt vegetarian and gluten-free diets (GFD) increases daily. More recently, a new entity, non-celiac gluten sensitivity (NCGS), with a still evolving definition and clinical spectrum, has been described...
2016: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/27304256/opioid-peptides-and-gastrointestinal-symptoms-in-autism-spectrum-disorders
#8
Cristiane P Lázaro, Milena P Pondé, Luiz E A Rodrigues
Autism spectrum disorders (ASDs) are characterized by deficits in the individual's ability to socialize, communicate, and use the imagination, in addition to stereotyped behaviors. These disorders have a heterogenous phenotype, both in relation to symptoms and regarding severity. Organic problems related to the gastrointestinal tract are often associated with ASD, including dysbiosis, inflammatory bowel disease, exocrine pancreatic insufficiency, celiac disease, indigestion, malabsorption, food intolerance, and food allergies, leading to vitamin deficiencies and malnutrition...
July 2016: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/27050467/neurological-disorders-and-celiac-disease
#9
Giovanni Casella, Bianca M Bordo, Renzo Schalling, Vincenzo Villanacci, Marianna Salemme, Camillo DI Bella, Vittorio Baldini, Gabrio Bassotti
Celiac Disease (CD) determins Neurologic Manifestations in 10% of all CD patients. We describe the most common clinical manifestations as Cerebellar Ataxia, Gluten Encephalopathy, Multiple Sclerosis, Peripheral Neuropathies, SensoriNeural Hearing Loss, Epilepsy, Headache, Depression, Cognitive Deficiencies and other less decribed clinical conditions. Our aim is to perform, as more as possible, a review about the most recent update on the topics in international literature. It is important to consider clinical neurological manifestations in Celiac patients and to research these conditions also in the follow- up because they may start also 1 year after the start of Gluten Free Diet (GFD) as Peripheral Neuropathy...
April 6, 2016: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/26619901/neurological-disorders-and-celiac-disease
#10
Giovanni Casella, Bianca M Bordo, Renzo Schalling, Vincenzo Villanacci, Marianna Salemme, Camillo Di Bella, Vittorio Baldini, Gabrio Bassotti
Celiac disease (CD) determines neurologic manifestations in 10% of all CD patients. We describe the most common clinical manifestations as cerebellar ataxia, gluten encephalopathy, multiple sclerosis, peripheral neuropathies, sensorineural hearing loss, epilepsy, headache, depression, cognitive deficiencies and other less described clinical conditions. Our aim is to perform, as more as possible, a review about the most recent update on the topics in international literature. It is important to consider clinical neurological manifestations in celiac patients and to research these conditions also in the follow-up because they may start also one year after the start of gluten free diet (GFD) as peripheral neuropathy...
June 2016: Minerva Gastroenterologica e Dietologica
https://www.readbyqxmd.com/read/26605537/gluten-sensitivity
#11
Carlo Catassi
Non-celiac gluten sensitivity (NCGS) is a syndrome characterized by intestinal and extraintestinal symptoms related to the ingestion of gluten-containing food in subjects who are not affected by either celiac disease (CD) or wheat allergy (WA). The prevalence of NCGS is not clearly defined yet. Indirect evidence suggests that NCGS is slightly more common than CD, the latter affecting around 1% of the general population. NCGS has been mostly described in adults, particularly in females in the age group of 30-50 years; however, pediatric case series have also been reported...
2015: Annals of Nutrition & Metabolism
https://www.readbyqxmd.com/read/26434032/the-gluten-free-frenzy-fad-or-fitting
#12
Linda Johanson
Although the gluten-free diet has been recognized as therapeutic for individuals suffering from celiac disease, it has been promoted recently for other indications, such as autism, chronic fatigue syn- drome, and irritable bowel syndrome, or simply as a healthy dietary choice for anyone. The basics of the gluten-free diet are explored, with evidence-based indications and nursing implications when patients choose gluten-free.
July 2015: Medsurg Nursing: Official Journal of the Academy of Medical-Surgical Nurses
https://www.readbyqxmd.com/read/26203574/-non-celiac-gluten-sensitivity-another-condition-that-responds-to-gluten
#13
REVIEW
Elizabeth Navarro, Magdalena Araya
Remission of gastrointestinal and general symptoms after gluten withdrawal has been described in some non-celiac individuals for nearly 30 years. Only recently, efforts have been made to define this entity, now referred to as "non-celiac gluten sensitivity". It includes patients that clinically respond to gluten free diet without exhibiting allergic or autoimmune features to explain such response. Wheat allergy, celiac disease, irritable bowel syndrome and symptoms induced by high FODMAPs (Fermentable, Oligo-, Di-, Mono-saccharides And Polyols) consumption are the main differential diagnoses...
May 2015: Revista Médica de Chile
https://www.readbyqxmd.com/read/26190965/brain-fog-inflammation-and-obesity-key-aspects-of-neuropsychiatric-disorders-improved-by-luteolin
#14
REVIEW
Theoharis C Theoharides, Julia M Stewart, Erifili Hatziagelaki, Gerasimos Kolaitis
Brain "fog" is a constellation of symptoms that include reduced cognition, inability to concentrate and multitask, as well as loss of short and long term memory. Brain "fog" characterizes patients with autism spectrum disorders (ASDs), celiac disease, chronic fatigue syndrome, fibromyalgia, mastocytosis, and postural tachycardia syndrome (POTS), as well as "minimal cognitive impairment," an early clinical presentation of Alzheimer's disease (AD), and other neuropsychiatric disorders. Brain "fog" may be due to inflammatory molecules, including adipocytokines and histamine released from mast cells (MCs) further stimulating microglia activation, and causing focal brain inflammation...
2015: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/26184290/gluten-psychosis-confirmation-of-a-new-clinical-entity
#15
Elena Lionetti, Salvatore Leonardi, Chiara Franzonello, Margherita Mancardi, Martino Ruggieri, Carlo Catassi
Non-celiac gluten sensitivity (NCGS) is a syndrome diagnosed in patients with symptoms that respond to removal of gluten from the diet, after celiac disease and wheat allergy have been excluded. NCGS has been related to neuro-psychiatric disorders, such as autism, schizophrenia and depression. A singular report of NCGS presenting with hallucinations has been described in an adult patient. We report a pediatric case of a psychotic disorder clearly related to NCGS and investigate the causes by a review of literature...
July 8, 2015: Nutrients
https://www.readbyqxmd.com/read/24693281/gluten-sensitivity-presenting-as-a-neuropsychiatric-disorder
#16
REVIEW
Stephen J Genuis, Rebecca A Lobo
There has been increasing recognition in the medical community and the general public of the widespread prevalence of gluten sensitivity. Celiac disease (CD) was initially believed to be the sole source of this phenomenon. Signs and symptoms indicative of nonceliac gluten sensitivity (NCGS), in which classical serum and intestinal findings of CD may be absent, have been frequently reported of late. Clinical manifestations in patients with NCGS are characteristically triggered by gluten and are ameliorated or resolved within days to weeks of commencing a gluten-free diet...
2014: Gastroenterology Research and Practice
https://www.readbyqxmd.com/read/24339339/gut-permeability-in-autism-spectrum-disorders
#17
Neil Dalton, Susie Chandler, Charles Turner, Tony Charman, Andrew Pickles, Tom Loucas, Emily Simonoff, Peter Sullivan, Gillian Baird
OBJECTIVE: To test whether gut permeability is increased in autism spectrum disorders (ASD) by evaluating gut permeability in a population-derived cohort of children with ASD compared with age- and intelligence quotient-matched controls without ASD but with special educational needs (SEN). PATIENTS AND METHODS: One hundred thirty-three children aged 10-14 years, 103 with ASD and 30 with SEN, were given an oral test dose of mannitol and lactulose and urine collected for 6 hr...
June 2014: Autism Research: Official Journal of the International Society for Autism Research
https://www.readbyqxmd.com/read/24077239/non-celiac-gluten-sensitivity-the-new-frontier-of-gluten-related-disorders
#18
REVIEW
Carlo Catassi, Julio C Bai, Bruno Bonaz, Gerd Bouma, Antonio Calabrò, Antonio Carroccio, Gemma Castillejo, Carolina Ciacci, Fernanda Cristofori, Jernej Dolinsek, Ruggiero Francavilla, Luca Elli, Peter Green, Wolfgang Holtmeier, Peter Koehler, Sibylle Koletzko, Christof Meinhold, David Sanders, Michael Schumann, Detlef Schuppan, Reiner Ullrich, Andreas Vécsei, Umberto Volta, Victor Zevallos, Anna Sapone, Alessio Fasano
Non Celiac Gluten sensitivity (NCGS) was originally described in the 1980s and recently a "re-discovered" disorder characterized by intestinal and extra-intestinal symptoms related to the ingestion of gluten-containing food, in subjects that are not affected with either celiac disease (CD) or wheat allergy (WA). Although NCGS frequency is still unclear, epidemiological data have been generated that can help establishing the magnitude of the problem. Clinical studies further defined the identity of NCGS and its implications in human disease...
October 2013: Nutrients
https://www.readbyqxmd.com/read/24045522/-investigation-on-a-group-of-autistic-children-risk-factors-and-medical-social-considerations
#19
G M Troili, R Businaro, F Massoni, L Ricci, L Petrone, P Ricci, S Ricci
AIMS: The aim of this work is to study the association between autism in a group of autistic children and risk factors for specific familiar diseases and developmental disease in the early years of life, through a medical social investigation. MATERIALS AND METHODS: For this study, we have submitted an anamnestic questionnaire to 29 autistic children and their families in a South Italy region (Basilicata), collecting data about children and their parents. RESULTS: The results show that many children have a family history of autoimmune diseases (psoriasis, rheumatoid arthritis, celiac disease, Takayasu's arteritis), allergies and food intolerances, suggesting a putative involvement of the immune system in autism etiopathogenesis...
2013: La Clinica Terapeutica
https://www.readbyqxmd.com/read/23991491/-chronic-disease-and-health-condition-prevention-in-childhood-emphases-from-the-13th-symposium-of-preventive-pediatrics
#20
Maja Batinica, Josip Grgurić, Filip Jadrijević-Cvrlje
Chronic diseases in childhood have become an important priority, especially in developed countries, because of higher prevalence, relatively and absolutely. Besides that, inappropriate procedures a chronically ill child can result in child's growth and development disorder. According to literature data, 15-20% of children have chronic disease with the impact on their physical, mental and emotional status. Disease prevention strategies are described at the primary, secondary and tertiary level: how to avoid occurrence of disease, how to diagnose and treat existent disease in early stages, before it causes significant morbidity, and finally how to reduce negative impact of existent disease by restoring function and reducing disease-related complications - how to improve quality of life of children with chronic diseases...
July 2013: Lijec̆nic̆ki Vjesnik
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