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https://www.readbyqxmd.com/read/29169220/fermented-soymilk-alleviates-lipid-accumulation-by-inhibition-of-srebp-1-and-activation-of-nrf-2-in-the-hepatocellular-steatosis-model
#1
Sang Bong Ahn, Wen Hao Wu, Jong Hun Lee, Dae Won Jun, Jihyun Kim, Riji Kim, Tae-Bok Lee, Jin Hyun Jun
Ingredients of soy and fermented soy products have been widely utilized as food supplements for health-enhancing properties. The aim was to evaluate the effects of fermented soymilk (FSM) and soymilk (SM) on the free fatty acid-induced lipogenesis in the hepatocellular steatosis model. HepG2 cells were incubated with palmitic acid (PA) for 24 h to induce lipogenesis and accumulation of intracellular lipid contents. The PA treated cells were co-incubated with FSM, SM, genistein, and estrogen, respectively. Lipid accumulations in the PA-treated HpG2 cells were significantly decreased by co-incubation with FSM...
November 25, 2017: Journal of Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29169181/inflammatory-cytokine-il-8-cxcl8-promotes-tumour-escape-from-hepatocyte-induced-dormancy
#2
Ahmad S Khazali, Amanda M Clark, Alan Wells
BACKGROUND: Breast cancers can recur after a long latency period following 'successful' primary treatments. Chronic inflammation significantly correlates with reduced diseased-free survival in breast cancer patients and could be a point of intervention to prevent recurrence. Liver is among the main sites of breast cancer recurrence. Thus, we hypothesise that inflammatory signals from hepatic stellate cells, the major inflammatory regulators in the sinusoid, could stimulate dormant cancer cells to emerge...
November 23, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/29169180/mitochondria-targeted-antioxidant-mito-tempo-protects-against-aldosterone-induced-renal-injury-in-vivo
#3
Wei Ding, Tingyan Liu, Xiao Bi, Zhiling Zhang
BACKGROUND/AIMS: Growing evidence suggests mitochondrial dysfunction (MtD) and the Nlrp3 inflammasome play critical roles in chronic kidney disease (CKD) progression. We previously reported that Aldosterone (Aldo)-induced renal injury in vitro is directly caused by mitochondrial reactive oxygen species (mtROS)-mediated activation of the Nlrp3 inflammasome. Here we aimed to determine whether a mitochondria-targeted antioxidant (Mito-Tempo) could prevent Aldo-induced kidney damage in vivo...
November 23, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29169155/rho-kinase-regulates-aortic-vascular-smooth-muscle-cell-stiffness-via-actin-srf-myocardin-in-hypertension
#4
Ning Zhou, Jia-Jye Lee, Shaunrick Stoll, Ben Ma, Kevin D Costa, Hongyu Qiu
BACKGROUND/AIMS: Our previous studies demonstrated that intrinsic aortic smooth muscle cell (VSMC) stiffening plays a pivotal role in aortic stiffening in aging and hypertension. However, the underlying molecular mechanisms remain largely unknown. We here hypothesized that Rho kinase (ROCK) acts as a novel mediator that regulates intrinsic VSMC mechanical properties through the serum response factor (SRF) /myocardin pathway and consequently regulates aortic stiffness and blood pressure in hypertension...
November 23, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29169152/knockdown-of-caveolin-1-sensitizes-human-basal-like-triple-negative-breast-cancer-cells-to-radiation
#5
Man Zou, Yanhui Li, Shu Xia, Qian Chu, Xiaoguang Xiao, Hong Qiu, Yu Chen, Zu'an Zheng, Fei Liu, Liang Zhuang, Shiying Yu
BACKGROUND/AIMS: Triple-negative breast cancer (TNBC) is a high-risk breast cancer phenotype without specific targeted therapy options and is significantly associated with increased local recurrence in patients treated with radiotherapy. CAVEOLIN-1 (CAV-1)-mediated epidermal growth factor receptor (EGFR) nuclear translocation following irradiation promotes DNA repair and thus induces radiation resistance. In this study, we aimed to determine whether knockdown of CAV-1 enhances the radiosensitivity of basal-like TNBC cell lines and to explore the possible mechanisms...
November 23, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29169106/the-transcriptomic-changes-of-huipizhi-heidou-glycine-max-a-nematode-resistant-black-soybean-during-heterodera-glycines-race-3-infection
#6
Shuang Li, Yu Chen, Xiaofeng Zhu, Yuanyuan Wang, Ki-Hong Jung, Lijie Chen, Yuanhu Xuan, Yuxi Duan
Glycine max (soybean) is an extremely important crop, representing a major source of oil and protein for human beings. Heterodera glycines (soybean cyst nematode, SCN) infection severely reduces soybean production; therefore, protecting soybean from SCN has become an issue for breeders. Black soybean has exhibited a different grade of resistance to SCN. However, the underlying mechanism of Huipizhi Heidou resistance against SCN remains elusive. The Huipizhi Heidou (ZDD2315) and race 3 of Heterodera glycines were chosen to study the mechanism of resistance via examination of transcriptomic changes...
November 14, 2017: Journal of Plant Physiology
https://www.readbyqxmd.com/read/29169084/changes-in-first-trimester-fetal-cyp1a1-and-ahrr-dna-methylation-and-mrna-expression-in-response-to-exposure-to-maternal-cigarette-smoking
#7
Svetlana Fa, Trine Vilsbøll Larsen, Katrine Bilde, Tina F Daugaard, Emil H Ernst, Karin Lykke-Hartmann, Rasmus H Olesen, Linn S Mamsen, Erik Ernst, Agnete Larsen, Anders L Nielsen
Prenatal exposure to maternal cigarette smoking increases the risk of intrauterine growth retardation, adverse pregnancy outcomes, and diseases later in life. Exposure can result in postnatal global and gene-specific DNA methylation changes, with the latter well documented for the CYP1A1 and AHRR genes involved in the detoxification of xenobiotic substances. This study assessed the impact of exposure to maternal smoking on first trimester fetal CYP1A1 and AHRR mRNA expression and DNA methylation for CpG-sites displaying maternal smoking during pregnancy-mediated methylation changes at birth...
November 16, 2017: Environmental Toxicology and Pharmacology
https://www.readbyqxmd.com/read/29169044/esculentoside-a-specifically-binds-to-ribosomal-protein-s3a-and-impairs-lps-induced-signaling-in-macrophages
#8
Ying-Hua Li, Jing Wang, Ying Liu, Lie Qiu, Jian-Zhong Li, Hong-Gang Hu, Zhen-Lin Hu, Wen Zhang, Bin Lu, Jun-Ping Zhang
Esculentoside A (EsA), a saponin isolated from Phytolacca esculenta, is reported as a potent suppressor of pro-inflammatory functions of macrophages. However, little is known about the target proteins of EsA for its anti-inflammatory activity. In the present study, to identify the intracellular target for EsA, affinity resins bearing immobilized EsA were used to capture binding proteins of EsA from RAW264.7 cell lysates. Mass spectrography and Western blot analysis of captured proteins indicated that ribosomal protein S3a preferentially bound to EsA affinity resin...
November 20, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/29168976/biological-therapies-in-psoriasis-revisited
#9
Maria-Isabela Sârbu, Simona-Roxana Georgescu, Mircea Tampa, Alexandra-Elena Sârbu, Olga Simionescu
Psoriasis is a chronic, immune mediated disorder affecting approximately 2% of the population. Even in our days, patients with psoriasis are confronted with stigmatization and social rejection. As a result, their quality of life is significantly impaired. Biological therapies have revolutionized the treatment of moderate to severe psoriasis. The aim of this paper is to look over the most important biological therapies available for the management of plaque-type psoriasis.
November 27, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/29168929/kinin-b1-receptors-as-a-therapeutic-target-for-inflammation
#10
Fatimunnisa Qadri, Michael Bader
Kinins are peptide mediators exerting their pro-inflammatory actions by the selective stimulation of two distinct G-protein coupled receptors, termed BKB1R and BKB2R. While BKB2R is constitutively expressed in a multitude of tissues, BKB1R is hardly expressed at baseline but highly inducible by inflammatory mediators. In particular, BKB1R was shown to be involved in the pathogenesis of numerous inflammatory diseases. Areas covered: This review intends to evaluate the therapeutic potential of substances interacting with the BKB1R...
November 23, 2017: Expert Opinion on Therapeutic Targets
https://www.readbyqxmd.com/read/29168928/regulation-of-kv1-4-potassium-channels-by-pkc-and-ampk-kinases
#11
Martin Nybo Andersen, Lasse Skibsbye, Arnela Saljic, Martin Zahle Larsen, Hanne Borger Rasmussen, Thomas Jespersen
Over the last years extensive kinase-mediated regulation of a number of voltage-gated potassium (Kv) channels important in cardiac electrophysiology has been reported. This includes regulation of Kv1.5, Kv7.1 and Kv11.1 cell surface expression, where the kinase-mediated regulation appears to center around the ubiquitin ligase Nedd4-2. In the present study we examined whether Kv1.4, constituting the cardiac Ito,s current, is subject to similar regulation. In the epithelial Madin-Darby Canine Kidney (MDCK) cell line, which constitutes a highly reproducible model system for addressing membrane targeting, we find, by confocal microscopy, that Kv1...
November 23, 2017: Channels
https://www.readbyqxmd.com/read/29168897/early-socioeconomic-conditions-and-severe-tooth-loss-in-middle-aged-costa-ricans
#12
Romain Fantin, Cyrille Delpierre, Michelle Kelly-Irving, Cristina Barboza Solís
OBJECTIVE: A wide literature shows a strong social gradient in tooth loss according to income, education and occupation, in both developed and developing countries. It has been shown associations between tooth loss and parental education and occupation, independently of adult conditions. To explore the role of early socioeconomic circumstances on tooth loss, we used a lifecourse model. We analysed the direct and indirect links between early socioeconomic conditions and severe adult tooth loss...
November 23, 2017: Community Dentistry and Oral Epidemiology
https://www.readbyqxmd.com/read/29168893/oral-tolerance-modulates-the-skin-transcriptome-in-mice-with-induced-atopic-dermatitis
#13
Jin Ok Baek, Jong Rok Lee, Joo Young Roh, YunJae Jung
Defective gut immune reactions have been implicated in the development of atopic dermatitis (AD), whereas oral tolerance (OT), i.e., the immune unresponsiveness induced by oral antigen administration, protects mice against AD. To investigate this protective role of OT, the transcriptomic profiles of skin were obtained by RNA sequencing from mice that were epicutaneously sensitized, orally tolerized prior to epicutaneous sensitization, or neither (control). OT inhibited the upregulation of keratin- and allergic inflammation-associated genes that occurred in the epicutaneously sensitized group...
November 23, 2017: Allergy
https://www.readbyqxmd.com/read/29168882/fibroblast-growth-factor-2-regulates-activity-and-gene-expression-of-human-postmitotic-excitatory-neurons
#14
Shweta Gupta, Tanya M-Redmond, Fan Meng, Andrew Tidball, Huda Akil, Stanley Watson, Jack M Parent, Michael Uhler
Many neuropsychiatric disorders are thought to result from subtle changes in neural circuit formation. We used human embryonic stem cells (hESCs) and induced pluripotent stem cells (hiPSCs) to model mature, postmitotic excitatory neurons and examine effects of FGF2. FGF2 gene expression is known to be altered in brain regions of major depressive disorder (MDD) patients and FGF2 has anti-depressive effects in animal models of depression. We generated stable inducible neurons (siNeurons) conditionally expressing human neurogenin 2 (NEUROG2) to generate a homogenous population of post-mitotic excitatory neurons and study the functional as well as the transcriptional effects of FGF2...
November 23, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29168870/hybrid-compounds-assembled-from-copper-triazole-complexes-and-phosphomolybdic-acid-as-advanced-catalysts-for-the-oxidation-of-olefins-with-oxygen
#15
Xiaojing Song, Yan Yan, Yanning Wang, Dianwen Hu, Lina Xiao, Jiehui Yu, Wenxiang Zhang, Mingjun Jia
Two hybrid compounds, namely [Cu(3atrz)4][PMoMo(V)O40] (1) and [Cu(3atrz)6][PMo12O40]2 (2), were synthesized through hydrothermal reactions of 3-amino-1,2,4-triazole (3atrz), phosphomolybdic acid (PMA) and appropriate copper salts. Crystal structure analysis reveals that compound 1 contains one-dimensional Cu-3atrz chains. The unit of compound 2 contains a double calyx[3]arene-shaped hexamer, which is composed of six two-coordinated Cu(I) atoms and six 3atrz ligands. Both compounds 1 and 2 present a three-dimensional hybrid structure, which is built by the self-assembly of Cu-3atrz clusters and Keggin-type PMA units...
November 23, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29168861/binding-of-al-iii-to-synthetic-rna-and-metal-mediated-strand-aggregation
#16
Matteo Lari, Tarita Biver, Natalia Busto, Héctor J Lozano, José M Leal, Fernando Secco, Begoña García
Over the last few years, focused interest in aluminum has been heightened by recent studies regarding its health effects. Its possible relation with chronic diseases makes it convenient to address more in depth the reactivity of aluminum with biologically relevant molecules. The present work investigates the interaction of the aluminum ion with two synthetic RNAs, poly(rA) and poly(rU), through a detailed thermodynamic and kinetic study. The trivalent aluminum ion was kept in solution by complexation with the cacodylate anion, even at neutral pH, thus making the study with biological molecules feasible...
November 23, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29168855/high-adjuvant-activity-of-layered-double-hydroxide-nanoparticles-and-nanosheets-in-anti-tumour-vaccine-formulations
#17
Shiyu Yan, Wenyi Gu, Bing Zhang, Barbara E Rolfe, Zhi Ping Xu
Effective adjuvants in anti-tumour vaccine formulations are very important in the development of new-generation vaccines. In this study, two layered double hydroxide (LDH) nanomaterial forms, i.e. nanoparticles (NPs) and nanosheets (NSs), were synthesised and examined as adjuvants to provoke the immune responses for anti-tumour purpose. Immunogen ovalbumin (OVA) delivered by both nanomaterials induced much stronger humoral and cell-medicated immune responses, together with an immune stimulant (TLR9 ligand CpG), as evidenced by higher levels of IgG1, IgG2a and interferon-γ...
November 23, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29168852/imidazole-synthesis-by-transition-metal-free-base-mediated-deaminative-coupling-of-benzylamines-and-nitriles
#18
Uttam Kumar Das, Linda J W Shimon, David Milstein
A transition metal free, straightforward synthetic method for the preparation of substituted imidazoles is reported herein. Base promoted, deaminative coupling of benzylamines with nitriles results in the one-step synthesis of 2,4,5-trisubstituted imidazoles with liberation of ammonia. This protocol provides a practical strategy for the synthesis of valuable imidazole derivatives from readily available starting materials.
November 23, 2017: Chemical Communications: Chem Comm
https://www.readbyqxmd.com/read/29168849/highly-effective-target-converting-strategy-for-ultrasensitive-electrochemical-assay-of-hg-2
#19
Jin Lv, Shunbi Xie, Wei Cai, Jin Zhang, Dianyong Tang, Ying Tang
An electrochemical sensing system based on a highly effective mercuric ion (Hg(2+)) converting strategy and rolling circle amplification (RCA) is developed for the ultrasensitive detection of Hg(2+). The Hg(2+) converting strategy is implemented based on Hg(2+) specific recognition thymine-Hg(2+)-thymine (T-Hg(2+)-T)-induced DNA strand displacement. First, polystyrene magnetic microspheres coated by AuNPs (Au@PSC) as a magnetic separator were labeled with ssDNA D1 (thymine-rich) and S1/D2 DNA duplex (guanine-rich S1)...
November 23, 2017: Analyst
https://www.readbyqxmd.com/read/29168848/an-etching-based-fluorescent-probe-for-sensitive-detection-of-hydrogen-sulfide-in-cells
#20
Yali Dong, Ling Wang, Feng Wang, Nan Li, Yi Jin, Jinchao Zhang, Xinjian Yang
Hydrogen sulfide (H2S) is one of the most crucial gas signaling agents that mediate many physiological and pathological processes. However, rapid high-efficiency detection and imaging of H2S in living cells is very challenging. Herein we reported a simple fluorescent nanoprobe using FAM-DNA/AgNP nanocomposites for fast and sensitive H2S detection based on surface silver displacement. In contrast to the conventional principles for fluorescence turn-on analyte detection, the present work demonstrated a sensitive and selective AgNP based optosensor for the assay of H2S...
November 23, 2017: Analyst
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