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hemolysis in aps

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https://www.readbyqxmd.com/read/27578899/bentall-surgery-in-a-patient-with-cold-agglutinin-and-antiphospholipid-antibody-double-trouble
#1
Monish S Raut, Gulshan Rohra, Ganesh Shivnani, Arun Maheshwari, Sumir Dubey, Rajpal Singh Bhathiwal, Deevakar Sharma
Cold agglutinin disease is an uncommon disease with potential to cause hemolysis and thrombosis during hypothermic cardiac surgery. Antiphospholipid syndrome is also rare disease with hypercoagulation tendacy. Perioperative management of both these diseases is challenging. We present successful perioperative management of high risk Bentall surgery in patient with both these dreadful diseases.
June 2016: Journal of Extra-corporeal Technology
https://www.readbyqxmd.com/read/27116985/-variation-of-long-chain-3-hydroxyacyl-coa-dehydrogenase-dna-methylated-modification-and-correlation-with-gene-mrna-expression-of-early-onset-preeclampsia-hellp-syndrome-and-antiphospholipid-syndrome-in-trophoblast-cells-of-placenta
#2
R Meng, Z Yang, H L Wang, Y W Han, Y L Wang, H Yu
OBJECTIVE: By detecting the DNA methylation and gene expression of long-chain 3-hydroxyacyl CoA dehydrogenase(LCHAD)in trophoblast cells, analyze the correlation of DNA methylation and gene expression in early-onset preeclampsia(EPE), hemolysis, elevated liver enzymes, and low platelets(HELLP)syndrome and antiphospholipid syndrome(APS), to investigate the molecular basis of long-chain fatty acid oxidation changes in different preeclampsia and pathological pregnancy. METHODS: Primary human cytotrophoblast cells and HTR8/Svneo cells were treated with serum from patients with EPE(14 cases), HELLP(12 cases), APS(14 cases), and normal pregnant women(NP, 14 cases)...
April 25, 2016: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/27023104/catastrophic-antiphospholipid-syndrome-in-pregnancy-a-diagnosis-that-should-not-be-missed
#3
Jennifer G Hoayek, Hind N Moussa, Hina A Rehman, Susan Hosseini Nasab, Sean C Blackwell, Baha M Sibai
Catastrophic antiphospholipid syndrome (CAPS) is an accelerated form of the antiphospholipid antibody syndrome resulting in multi-organ ischemia and failure. It is a rare and life-threatening condition that can be easily mistaken with hemolysis elevated liver enzymes low platelets syndrome, thrombotic thrombocytopenic purpura, and hemolytic uremic syndrome. In order to make a diagnosis, it is required to have multi-organ thrombosis over 1 week affecting at least three organs or systems, and to have positive antiphospholipid antibody on two occasions (6 weeks apart), and histopathologic confirmation of small vessel occlusion...
December 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27022879/ald-mediated-heparin-grafting-on-nitinol-for-self-expanded-carotid-stents
#4
Fei Wang, Yan Zhang, Xiumian Chen, Bing Leng, Xin Guo, Tao Zhang
Carotid-artery atherosclerosis is a common cause of ischemic stroke. Carotid-artery stenting (CAS) is one of the most effective treatments. However, In-stent restenosis (ISR) and re-endothelialization delay are two major issues of intravascular stent which affect clinical safety and reduce effects. In this study, atomic layer deposition (ALD) technology was applied to deposit a layer (10nm) of Al2O3 on Nitinol surface as an intermediate functional layer. The alumina covered surface was then modified with a coupling agent 3-aminopropyltriethoxysilane (APS) and heparin sequentially in order to improve the hemocompatibility of Nitinol stents...
July 1, 2016: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/26861770/synthesis-characterization-and-in-vitro-evaluation-of-exquisite-targeting-spions-peg-her-in-her2-human-breast-cancer-cells
#5
Javad Hamzehalipour Almaki, Rozita Nasiri, Ani Idris, Fadzilah Adibah Abdul Majid, Mojtaba Salouti, Tet Soon Wong, Shadab Dabagh, Mohsen Marvibaigi, Neda Amini
A stable, biocompatible and exquisite SPIONs-PEG-HER targeting complex was developed. Initially synthesized superparamagnetic iron oxide nanoparticles (SPIONs) were silanized using 3-aminopropyltrimethoxysilane (APS) as the coupling agent in order to allow the covalent bonding of polyethylene glycol (PEG) to the SPIONs to improve the biocompatibility of the SPIONs. SPIONs-PEG were then conjugated with herceptin (HER) to permit the SPIONs-PEG-HER to target the specific receptors expressed over the surface of the HER2+ metastatic breast cancer cells...
March 11, 2016: Nanotechnology
https://www.readbyqxmd.com/read/25963541/multiplug-paravalvular-leak-closure-using-amplatzer-vascular-plugs-iii-a-prospective-registry
#6
Grzegorz Smolka, Piotr Pysz, Marek Jasiński, Tomasz Roleder, Ewa Peszek-Przybyła, Andrzej Ochała, Wojciech Wojakowski
BACKGROUND: Transcatheter paravalvular leak closure (TPVLC) offers a viable alternative to reoperation but optimal technical strategy is still to be defined. We present a prospective TPVLC registry in which safety and efficacy of multi-plug, single-stage approach were assessed. METHODS: Patients with heart failure (HF) symptoms caused by PVL were qualified for TPVLC by Heart Team. Ante- or retrograde access was employed for mitral while retrograde only for aortic PVLs...
February 15, 2016: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/25879992/differentiation-between-severe-hellp-syndrome-and-thrombotic-microangiopathy-thrombotic-thrombocytopenic-purpura-and-other-imitators
#7
REVIEW
O Pourrat, R Coudroy, F Pierre
Pre-eclampsia complicated by severe HELLP (hemolysis, elevated liver enzymes and low platelet count) syndrome is a multi-organ disease, and can be difficult to differentiate from thrombotic microangiopathy (appearing as thrombotic thrombocytopenic purpura or hemolytic uremic syndrome), acute fatty liver, systemic erythematous lupus, antiphospholipid syndrome and severe sepsis. Many papers have highlighted the risks of misdiagnosis resulting in severe consequences for maternal health, and this can be fatal when thrombotic thrombocytopenic purpura is misdiagnosed as severe HELLP syndrome...
June 2015: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/25818822/prevalence-of-the-american-college-of-rheumatology-hematological-classification-criteria-and-associations-with-serological-and-clinical-variables-in-460-systemic-lupus-erythematosus-patients
#8
Thelma Skare, Renata Damin, Renata Hofius
OBJECTIVE: To study systemic lupus erythematosus in a Brazilian population using the American College of Rheumatology hematological classification criteria and report associations of the disease with serological and clinical profiles. METHODS: This is a retrospective study of 460 systemic lupus erythematosus patients followed in a single rheumatologic center during the last 10 years. Hematological manifestations considered for this study were hemolysis, leukopenia, lymphocytopenia and thrombocytopenia...
March 2015: Revista Brasileira de Hematologia e Hemoterapia
https://www.readbyqxmd.com/read/25806101/hellp-syndrome-at-17-weeks-gestation-a-rare-and-catastrophic-phenomenon
#9
Erica L Berry, Sara N Iqbal
HELLP syndrome is a collection of symptoms described as hemolysis, elevated liver enzymes and low platelets. HELLP syndrome complicates 0.01-0.6% of pregnancies and can be considered a severe variant of preeclampsia. The occurrence of HELLP syndrome diagnosed before the 20th week of gestation has been most commonly reported in association with antiphospholipid antibody syndrome (APS) or triploid chromosomal anomalies. A 41-year-old primigravida was admitted at 17 weeks and 6 days gestation with hypertension, proteinuria, hemolytic anemia and acute renal injury...
December 2014: Journal of Clinical Gynecology and Obstetrics
https://www.readbyqxmd.com/read/25740297/effects-of-serum-from-patients-with-early-onset-pre-eclampsia-hellp-syndrome-and-antiphospholipid-syndrome-on-fatty-acid-oxidation-in-trophoblast-cells
#10
Huan Yu, Zi Yang, Xiaoyan Ding, Yanling Wang, Yiwei Han
BACKGROUND AND AIMS: The role of metabolic disorders of long-chain fatty acid oxidation in the development of pre-eclampsia (PE), hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome and antiphospholipid syndrome (APS) is unclear. The aim of this study was to research the effects of three serum on fatty acid oxidation in trophoblast cells. METHODS: Primary human trophoblast cells and HTR8/SVneo cells were treated with serum from patients with early-onset severe PE (E-PE), E-PE with HELLP (PE-HELLP), APS, and normal pregnant women as controls (NC)...
September 2015: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/25268121/evaluation-of-antioxidant-activities-of-ampelopsin-and-its-protective-effect-in-lipopolysaccharide-induced-oxidative-stress-piglets
#11
Xiang Hou, Jingfei Zhang, Hussain Ahmad, Hao Zhang, Ziwei Xu, Tian Wang
The aim of this study was to investigate the antioxidant potential of ampelopsin (APS) by using various methods in vitro, as well as to determine effects of APS on LPS-induced oxidative stress in piglets. The results showed that APS exhibited excellent free radical scavenging by DPPH, ABTS, O2•-, H2O2 and ferric reducing antioxidant power. Ampelopsin also protected pig erythrocytes against AAPH-induced apoptosis and hemolysis, decreased total superoxide dismutase activity, and increased lipid peroxidation...
2014: PloS One
https://www.readbyqxmd.com/read/24382555/diagnosis-and-management-of-obstetrical-antiphospholipid-syndrome-where-do-we-stand
#12
REVIEW
Tess Marchetti, Marie Cohen, Jean-Christophe Gris, Philippe de Moerloose
Obstetrical antiphospholipid syndrome (APS) is defined by obstetrical complications and the presence of antiphospholipid antibodies (aPL). Although the incidence of APS is still poorly known, this thrombophilia is now recognized as one of the most common acquired causes of recurrent fetal loss. The diagnosis of APS during pregnancy can be challenging because of its various clinical features. Mothers with APS have an increased risk of thrombosis, thrombopenia, and specific pregnancy‑related complications such as preeclampsia, eclampsia, and hemolysis elevated liver enzyme and low‑platelet syndrome...
2013: Polskie Archiwum Medycyny Wewnętrznej
https://www.readbyqxmd.com/read/23255492/polyurethanes-containing-zwitterionic-sulfobetaines-and-their-molecular-chain-rearrangement-in-water
#13
Jun Cao, Mou Yang, Aijing Lu, Shuying Zhai, Yuanwei Chen, Xianglin Luo
Novel polyurethanes with zwitterionic sulfobetaines, termed PUR-APS, were designed and synthesized by chain-extension of biodegradable poly(ε-caprolactone) containing N,N'-bis (2-hydroxyethyl) methylamine ammonium propane sulfonate (PCL-APS) with hexamethylene diisocyanate (HDI). The bulk properties of polymers were characterized by nuclear magnetic resonance spectrum (NMR), Fourier transform infrared spectroscopy (FTIR), gel permeation chromatograph (GPC), and differential scanning calorimetry (DSC). Results showed that the polymers were successfully synthesized...
March 2013: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/22811728/a-case-of-microangiopathic-antiphospholipid-associated-syndromes-during-pregnancy-review-of-the-literature
#14
Nobuhiro Suzumori, Shintaro Obayashi, Kyoko Kumagai, Shinobu Goto, Atsuhiro Yoshida, Mayumi Sugiura-Ogasawara
Microangiopathic antiphospholipid-associated syndromes (MAPSs) are reported as encompassing several conditions mainly affecting the microvasculature of selected organs: the liver in HELLP syndrome (hemolysis, elevated liver enzymes, and low platelet); kidney, brain, and skin in TTP (thrombotic thrombocytopenic purpura). It is predominant in patients with catastrophic antiphospholipid syndrome (APS). A recent report suggests that APS is not only a thrombotic disease but also associated with microangiopathic features, and it can explain the greater prevalence of HELLP syndrome in these patients...
2012: Case Reports in Medicine
https://www.readbyqxmd.com/read/22341691/-pregnancy-and-antiphospholipid-syndrome
#15
N Costedoat-Chalumeau, G Guettrot-Imbert, V Leguern, G Leroux, D Le Thi Huong, B Wechsler, N Morel, D Vauthier-Brouzes, M Dommergues, A Cornet, O Aumaître, O Pourrat, J-C Piette, J Nizard
Antiphospholipid syndrome (APS) is associated with a risk of obstetrical complications, affecting both the mother and the fetus. Obstetrical APS is defined by a history of three consecutive spontaneous miscarriages before 10 weeks of gestation (WG), an intra-uterine fetal death after 10 WG, or a premature birth before 34 WG because of severe pre-eclampsia, eclampsia or placental adverse outcomes (intrauterine growth retardation, oligohydramnios). Pregnancy in women with a diagnosis of obstetric APS is at increased risk for placental abruption, HELLP (Hemolysis, Elevated Liver enzymes, Low Platelet count) syndrome and thrombosis that may be part of a catastrophic antiphospholipid syndrome (CAPS)...
April 2012: La Revue de Médecine Interne
https://www.readbyqxmd.com/read/22339320/abo-antibody-titers-are-not-predictive-of-hemolytic-reactions-due-to-plasma-incompatible-platelet-transfusions
#16
Matthew S Karafin, Lorraine Blagg, Aaron A R Tobian, Karen E King, Paul M Ness, William J Savage
BACKGROUND: The overall risk of hemolytic transfusion reactions (HTRs) from plasma (minor)-incompatible platelet (PLT) transfusions and the role of a critical anti-A or anti-B titer in predicting and preventing these reactions has not been clearly established. STUDY DESIGN AND METHODS: We evaluated all apheresis PLT (AP) transfusions for 3 months. Using the gel titer method, we determined the anti-A and/or the anti-B immunoglobulin (Ig)G titer for all incompatible APs...
October 2012: Transfusion
https://www.readbyqxmd.com/read/22333233/-etiology-and-clinical-characteristics-of-pregnancy-emerged-thrombocytopenia
#17
Zhe Chen, Mei-ying Liang, Jian-liu Wang
OBJECTIVE: To investigate the etiology and clinical characteristics of pregnancy-emerged thrombocytopenia. METHODS: A retrospective analysis was conducted on clinical data of 159 pregnancies with thrombocytopenia, who were admitted to Peking University People's Hospital from January 2000 to January 2010. All the patients recruited in this study had no history of blood or immune system disease before pregnancy, and thrombocytopenia was the predominate clinical manifestation during pregnancy, with platelet counts less than 100 × 10(9)/L at least twice during pregnancy...
November 2011: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/21868064/hellp-syndrome-and-its-relationship-with-antiphospholipid-syndrome-and-antiphospholipid-antibodies
#18
REVIEW
Simone Appenzeller, Fernando H C Souza, Alexandre Wagner Silva de Souza, Yehuda Shoenfeld, Jozélio Freire de Carvalho
OBJECTIVE: To perform a systematic review of the association between antiphospholipid antibodies, antiphospholipid syndrome (APS), and HELLP syndrome (Hemolysis; Elevated Liver enzymes; Low Platelet count), describing clinical features, outcome, pathophysiological findings, and treatment. METHODS: We performed a literature search in PubMed using the following MeSH entry terms: HELLP syndrome, anticardiolipin antibodies, lupus anticoagulant, antiphospholipid antibodies, and antiphospholipid syndrome...
December 2011: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/21495169/enhancing-blood-compatibility-of-biodegradable-polymers-by-introducing-sulfobetaine
#19
Jun Cao, Yuan-Wei Chen, Xin Wang, Xiang-Lin Luo
Novel biodegradable polycaprolactone containing N,N'-bis (2-hydroxyethyl) methylamine ammonium propane sulfonate (PCL-APS) was synthesized by ring-opening polymerization. The resulting polymers were characterized by nuclear magnetic resonance spectrum (NMR), Fourier transform infrared (FTIR) spectroscopy, gel permeation chromatograph (GPC), differential scanning calorimetry (DSC), and water contact angle (WCA). These measurements showed that the APS unit was introduced into polymers. The hydrolysis of PCL-APS was evaluated by soaking the polymer membranes in a pH = 3...
June 15, 2011: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/21370215/antiphospholipid-syndrome-and-pre-eclampsia
#20
Lothar Heilmann, Martin Schorsch, Thomas Hahn, Jawed Fareed
Antiphospholipid syndrome (APS) is defined as an autoimmune disorder characterized by recurrent thrombosis or obstetrical morbidity. These features are linked to the presence in blood of autoantibodies against negatively charged phospholipids or phospholipid-binding proteins. Obstetric morbidity includes recurrent abortion (early and late) and severe pre-eclampsia (P-EC)/hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome, and/or severe placental insufficiency. Criteria that define the major clinical and laboratory events were published in revised forms in the Sydney recommendations in 2006...
March 2011: Seminars in Thrombosis and Hemostasis
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