Serim Pul, İbrahim Gökçe, Ece Demirci Bodur, Serçin Güven, Neslihan Çiçek, Mehtap Sak, Özde Nisa Türkkan, Deniz Filinte, Cemile Pehlivanoğlu, Betül Sözeri, Harika Alpay
BACKGROUND: Antiphospholipid syndrome (APS), particularly the catastrophic antiphospholipid syndrome (CAPS), is one of the rare causes of thrombotic microangiopathy (TMA). CAPS is the most severe form of APS, especially when accompanied by complement dysregulation, causes progressive microvascular thrombosis and failure in multiple organs. In this report, a case of CAPS with TMA accompanied by a genetic defect in the complement system is presented. CASE: A 13-year-old girl was admitted to the hospital with oliguric acute kidney injury, nephrotic range proteinuria, Coombs positive hemolysis, refractory thrombocytopenia, a low serum complement C3 level and anti-nuclear antibody (ANA) positivity...
2023: Turkish Journal of Pediatrics