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https://www.readbyqxmd.com/read/28917822/chemgenie-integration-of-chemogenomics-data-for-applications-in-chemical-biology
#1
REVIEW
Peter S Kutchukian, Charlie Chang, Sean J Fox, Erica Cook, Richard Barnard, David Tellers, Huijun Wang, Dante Pertusi, Meir Glick, Robert P Sheridan, Iain Wallace, Anne Mai Wassermann
Increasing amounts of biological data are accumulating in the pharmaceutical industry and academic institutions. However, data do not equal actionable information, and guidelines for appropriate data capture, harmonization, integration, mining, and visualization need to be established to fully harness their potential. Here, we describe ongoing efforts at Merck & Co. to structure data in the area of chemogenomics. We are integrating complementary data from both internal and external data sources into one chemogenomics database (Chemical Genetic Interaction Enterprise; CHEMGENIE)...
September 14, 2017: Drug Discovery Today
https://www.readbyqxmd.com/read/28917016/predictors-of-outpatient-resource-utilization-following-ventral-and-incisional-hernia-repair
#2
Alex Wade, Margaret A Plymale, Daniel L Davenport, Sara E Johnson, Vashisht V Madabhushi, Erica Mastoroudis, Charlie Tancula, John Scott Roth
INTRODUCTION: Little is known about the predictors of increased ambulatory costs following open ventral and incisional hernia repair (VIHR); however, postoperative complications would be expected to be associated with an increased burden on outpatient resources. The purpose of this study is to evaluate the impact of perioperative factors on outpatient resource utilization following VIHR. METHODS: With IRB approval, the surgery scheduling system was queried to identify all cases of VIHR done at our institution over 3 years...
September 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28916755/protein-o-fucosylation-in-plasmodium-falciparum-ensures-efficient-infection-of-mosquito-and-vertebrate-hosts
#3
Sash Lopaticki, Annie S P Yang, Alan John, Nichollas E Scott, James P Lingford, Matthew T O'Neill, Sara M Erickson, Nicole C McKenzie, Charlie Jennison, Lachlan W Whitehead, Donna N Douglas, Norman M Kneteman, Ethan D Goddard-Borger, Justin A Boddey
O-glycosylation of the Plasmodium sporozoite surface proteins CSP and TRAP was recently identified, but the role of this modification in the parasite life cycle and its relevance to vaccine design remain unclear. Here, we identify the Plasmodium protein O-fucosyltransferase (POFUT2) responsible for O-glycosylating CSP and TRAP. Genetic disruption of POFUT2 in Plasmodium falciparum results in ookinetes that are attenuated for colonizing the mosquito midgut, an essential step in malaria transmission. Some POFUT2-deficient parasites mature into salivary gland sporozoites although they are impaired for gliding motility, cell traversal, hepatocyte invasion, and production of exoerythrocytic forms in humanized chimeric liver mice...
September 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/28915341/-31-p-magnetic-resonance-fingerprinting-for-rapid-quantification-of-creatine-kinase-reaction-rate-in-vivo
#4
Charlie Y Wang, Yuchi Liu, Shuying Huang, Mark A Griswold, Nicole Seiberlich, Xin Yu
The purpose of this work was to develop a (31) P spectroscopic magnetic resonance fingerprinting (MRF) method for fast quantification of the chemical exchange rate between phosphocreatine (PCr) and adenosine triphosphate (ATP) via creatine kinase (CK). A (31) P MRF sequence (CK-MRF) was developed to quantify the forward rate constant of ATP synthesis via CK ( kfCK), the T1 relaxation time of PCr ( T1PCr), and the PCr-to-ATP concentration ratio ( MRPCr). The CK-MRF sequence used a balanced steady-state free precession (bSSFP)-type excitation with ramped flip angles and a unique saturation scheme sensitive to the exchange between PCr and γATP...
September 15, 2017: NMR in Biomedicine
https://www.readbyqxmd.com/read/28902889/on-specimen-killing-in-the-era-of-conservation-crisis-a-quantitative-case-for-modernizing-taxonomy-and-biodiversity-inventories
#5
Patrick O Waeber, Charlie J Gardner, Wilson R Lourenço, Lucienne Wilmé
BACKGROUND TO THE WORK: For centuries taxonomy has relied on dead animal specimens, a practice that persists today despite the emergence of innovative biodiversity assessment methods. Taxonomists and conservationists are engaged in vigorous discussions over the necessity of killing animals for specimen sampling, but quantitative data on taxonomic trends and specimen sampling over time, which could inform these debates, are lacking. METHODS: We interrogated a long-term research database documenting 2,723 land vertebrate and 419 invertebrate taxa from Madagascar, and their associated specimens conserved in the major natural history museums...
2017: PloS One
https://www.readbyqxmd.com/read/28901341/-healthcare-services-citizen-s-right-and-healthcare-systems-safeguard-considerations-rising-from-the-charlie-gard-story
#6
Giuseppe R Gristina
The story of Charlie Gard, an 11-month-old boy suffering from a rare inherited mitochondrial disease called 'infantile encephalomyopathic mitochondrial DNA depletion syndrome' and kept alive thanks to life supports, rises some issues regarding the provision of healthcare. Is there a right of an individual person to buy any healthcare benefits only because he has enough money to do so? If the answer is 'yes', in light of the distributive justice principle how do governments balance this right with the obligation to regulate health care systems ensuring that all treatments are useful and affordable for everybody? Many considerations of the best interest of patients can be found in this debate, but we cannot ignore neither the value of the scientific method as the cornerstone of the medical profession nor a commitment to support the moral integrity of clinical practice by refusing to provide treatments that do not meet a reasonable threshold of scientific justification evidence-based...
September 2017: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/28900862/the-influence-of-growth-and-maturation-on-stretch-shortening-cycle-function-in-youth
#7
REVIEW
John M Radnor, Jon L Oliver, Charlie M Waugh, Gregory D Myer, Isabel S Moore, Rhodri S Lloyd
Hopping, skipping, jumping and sprinting are common tasks in both active play and competitive sports. These movements utilise the stretch-shortening cycle (SSC), which is considered a naturally occurring muscle action for most forms of human locomotion. This muscle action results in more efficient movements and helps optimise relative force generated per motor unit recruited. Innate SSC development throughout childhood and adolescence enables children to increase power (jump higher and sprint faster) as they mature...
September 12, 2017: Sports Medicine
https://www.readbyqxmd.com/read/28899507/ziziphus-spinosa-seeds-for-insomnia-a-review-of-chemistry-and-psychopharmacology
#8
REVIEW
Johannah Linda Shergis, Xiaojia Ni, Jerome Sarris, Anthony Lin Zhang, Xinfeng Guo, Charlie C Xue, Chuanjian Lu, Helmut Hugel
BACKGROUND: In Chinese medicine, Ziziphus jujuba Mill. var. spinosa (Bunge) Hu ex H. F. Chou is widely used for the treatment of insomnia. PURPOSE/SECTIONS: This paper summarises the chemistry, psychopharmacology, and compares the pharmaceutical effects of the seeds of Ziziphus jujuba plant, Ziziphus spinosa (ZS) seeds, with benzodiazepines. Whole extracts and constituent compounds have been evaluated in preclinical and clinical studies. CONCLUSIONS: ZS secondary metabolites modulate GABAergic activity and the serotonergic system...
October 15, 2017: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/28892602/locating-advance-care-planning-facilitators-in-general-practice-increases-consumer-participation
#9
Jill Mann, Stephen D Gill, Lisa Mitchell, Margaret J Rogers, Peter Martin, Frances Quirk, Charlie Corke
BACKGROUND: Advance care planning (ACP) can positively affect end-of-life care experiences. However, uptake of ACP completion is low. The aim of this study was to investigate whether co-locating ACP facilitators in general practice increased participation METHODS: Barwon Health commenced promoting its ACP program in 2008. Trained ACP facilitators assisted consumers, which usually occurred in the program's community-based consulting rooms. From 2012 onwards, ACP facilitators were co-located with 18 general practices, where they assisted consumers at the point of care...
September 2017: Australian Family Physician
https://www.readbyqxmd.com/read/28883925/combining-creative-writing-and-narrative-analysis-to-deliver-new-insights-into-the-impact-of-pulmonary-hypertension
#10
Julia C Goddard, Iain J Armstrong, David G Kiely, Charlie A Elliot, Athanasios Charalampopoulos, Robin Condliffe, Brendan J Stone, Ian Sabroe
INTRODUCTION: Pulmonary hypertension is life limiting. Delays in diagnosis are common, and even after treatment has been initiated, pulmonary hypertension has marked effects on many aspects of social and physical function. We believed that a new approach to examining disease impact could be achieved through a combination of narrative research and creative writing. METHODS: Detailed unstructured narrative interviews with people with pulmonary hypertension were analysed thematically...
2017: BMJ Open Respiratory Research
https://www.readbyqxmd.com/read/28880161/unsupervised-segmentation-of-5d-hyperpolarized-carbon-13-mri-data-using-a-fuzzy-markov-random-field-model
#11
Ferdia A Gallagher, Charlie J Daniels
Hyperpolarized MRI with ¹³C-labelled compounds is an emerging clinical technique allowing in vivo metabolic processes to be characterized non-invasively. Accurate quantification of ¹³C data, both for clinical and research purposes, typically relies on the use of region-of-interest analysis to detect and compare regions of altered metabolism. However, it is not clear how this should be determined from the five-dimensional data produced and most standard methodologies are unable to exploit the multidimensional nature of the data...
September 4, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/28878183/a-novel-combination-of-wheat-peptides-and-fucoidan-attenuates-ethanol-induced-gastric-mucosal-damage-through-anti-oxidant-anti-inflammatory-and-pro-survival-mechanisms
#12
Juntao Kan, Molly Hood, Charlie Burns, Jeff Scholten, Jennifer Chuang, Feng Tian, Xingchang Pan, Jun Du, Min Gui
Gastritis or peptic ulcer is believed to affect about half of people worldwide. Traditional medications can lead to adverse effects, therefore, alternative nutritional strategies are needed to prevent the development of gastric mucosal damage. A novel combination of two food-grade ingredients, wheat peptides and fucoidan (WPF), was prepared to treat male Sprague Dawley rats for 30 days before gastric mucosal damage was induced by oral administration of ethanol. The serum levels of biomarkers were determined by enzyme-linked immunosorbent assay...
September 6, 2017: Nutrients
https://www.readbyqxmd.com/read/28874526/identification-of-individuals-by-trait-prediction-using-whole-genome-sequencing-data
#13
Christoph Lippert, Riccardo Sabatini, M Cyrus Maher, Eun Yong Kang, Seunghak Lee, Okan Arikan, Alena Harley, Axel Bernal, Peter Garst, Victor Lavrenko, Ken Yocum, Theodore Wong, Mingfu Zhu, Wen-Yun Yang, Chris Chang, Tim Lu, Charlie W H Lee, Barry Hicks, Smriti Ramakrishnan, Haibao Tang, Chao Xie, Jason Piper, Suzanne Brewerton, Yaron Turpaz, Amalio Telenti, Rhonda K Roby, Franz J Och, J Craig Venter
Prediction of human physical traits and demographic information from genomic data challenges privacy and data deidentification in personalized medicine. To explore the current capabilities of phenotype-based genomic identification, we applied whole-genome sequencing, detailed phenotyping, and statistical modeling to predict biometric traits in a cohort of 1,061 participants of diverse ancestry. Individually, for a large fraction of the traits, their predictive accuracy beyond ancestry and demographic information is limited...
September 5, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28869405/a-telehealth-intervention-to-promote-healthy-lifestyles-after-stroke-the-stroke-coach-protocol
#14
Brodie M Sakakibara, Scott A Lear, Susan I Barr, Oscar Benavente, Charlie H Goldsmith, Noah D Silverberg, Jennifer Yao, Janice J Eng
Rationale Recurrent stroke is prevalent and associated with high mortality rates, disability, and social and economic costs. Adequate management of risk factors may reduce recurrent stroke; however, many stroke survivors have poor control of risk factors. We have developed a theoretically sound and evidence-based lifestyle modification program called the Stroke Coach, a telephone-based self-management program to improve control of risk factors. Hypothesis Individuals who participate in Stroke Coach will achieve more lifestyle improvements than individuals in an attention controlled Memory Training Program...
January 1, 2017: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/28866623/epidemiology-management-and-outcome-of-ultrashort-bowel-syndrome-in-infancy
#15
REVIEW
Akshay Batra, Simon Charlie Keys, Mark John Johnson, Robert A Wheeler, Robert Mark Beattie
Ultrashort bowel syndrome (USBS) is a group of heterogeneous disorders where the length of small bowel is less than 10 cm or 10% of expected for the age. It is caused by massive loss of the gut which in the neonatal period can be a result of vanishing gastroschisis or surgical resection following mid-gut volvulus, jejunoileal atresia and/or extensive necrotising enterocolitis. The exact prevalence of USBS is not known although there is a clear trend towards increasing numbers because of increased incidence and improved survival...
September 2, 2017: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/28864672/the-coproporphyrin-ferrochelatase-of-staphylococcus-aureus-mechanistic-insights-into-a-regulatory-iron-binding-site
#16
Charlie Hobbs, J D Reid, Mark Shepherd
The majority of characterised ferrochelatase enzymes catalyse the final step of classical haem synthesis, inserting ferrous iron into protoporphyrin IX. However, for the recently-discovered coproporphyrin-dependent pathway, ferrochelatase catalyses the penultimate reaction where ferrous iron is inserted into coproporphyrin III. Ferrochelatase enzymes from the bacterial phyla Firmicutes and Actinobacteria have previously been shown to insert iron into coproporphyrin, and those from Bacillus subtilis and Staphylococcus aureus are known to be inhibited by elevated iron concentrations...
September 1, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28861519/an-aptamer-based-biosensor-for-the-azole-class-of-antifungal-drugs
#17
Gregory R Wiedman, Yanan Zhao, Arkady Mustaev, Jinglei Ping, Ramya Vishnubhotla, A T Charlie Johnson, David S Perlin
This technical report describes the development of an aptamer for sensing azole antifungal drugs during therapeutic drug monitoring. Modified synthetic evolution of ligands through exponential enrichment (SELEX) was used to discover a DNA aptamer recognizing azole class antifungal drugs. This aptamer undergoes a secondary structural change upon binding to its target molecule, as shown through fluorescence anisotropy-based binding measurements. Experiments using circular dichroism spectroscopy revealed a unique G-quadruplex structure that was essential and specific for binding to the azole antifungal target...
July 2017: MSphere
https://www.readbyqxmd.com/read/28854965/adipose-stem-cells-from-chronic-pancreatitis-patients-improve-mouse-and-human-islet-survival-and-function
#18
Lili Song, Zhen Sun, Do-Sung Kim, Wenyu Gou, Charlie Strange, Huansheng Dong, Wanxing Cui, Gary Gilkeson, Katherine A Morgan, David B Adams, Hongjun Wang
BACKGROUND: Chronic pancreatitis has surgical options including total pancreatectomy to control pain. To avoid surgical diabetes, the explanted pancreas can have islets harvested and transplanted. Immediately following total pancreatectomy with islet autotransplantation (TP-IAT), many islet cells die due to isolation and transplantation stresses. The percentage of patients remaining insulin free after TP-IAT is therefore low. We determined whether cotransplantation of adipose-derived mesenchymal stem cells (ASCs) from chronic pancreatitis patients (CP-ASCs) would protect islets after transplantation...
August 30, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/28853622/military-veteran-engagement-with-mental-health-and-well-being-services-a-qualitative-study-of-the-role-of-the-peer-support-worker
#19
Bronagh Weir, Margaret Cunningham, Lucy Abraham, Charlie Allanson-Oddy
BACKGROUND: Many UK military veterans experiencing mental health and well-being difficulties do not engage with support services to get the help they need. Some mental health clinics employ Peer Support Workers (PSWs) to help veteran patients engage, however it is not known how the role influences UK veteran engagement. AIMS: To gain insight into the role of peer support in UK veteran engagement with mental health and well-being services. METHOD: A qualitative study based on 18 semi-structured interviews with veterans, PSWs and mental health clinicians at a specialist veteran mental health and well-being clinic in Scotland...
August 30, 2017: Journal of Mental Health
https://www.readbyqxmd.com/read/28842466/il-18-drives-ilc3-proliferation-and-promotes-il-22-production-via-nf-%C3%AE%C2%BAb
#20
Aaron R Victor, Ansel P Nalin, Wenjuan Dong, Susan McClory, Min Wei, Charlene Mao, Raleigh D Kladney, Youssef Youssef, Wing Keung Chan, Edward L Briercheck, Tiffany Hughes, Steven D Scoville, Jason R Pitarresi, Charlie Chen, Sarah Manz, Lai-Chu Wu, Jianying Zhang, Michael C Ostrowski, Aharon G Freud, Gustavo W Leone, Michael A Caligiuri, Jianhua Yu
Group 3 innate lymphoid cells (ILC3s) are important regulators of the immune system, maintaining homeostasis in the presence of commensal bacteria, but activating immune defenses in response to microbial pathogens. ILC3s are a robust source of IL-22, a cytokine critical for stimulating the antimicrobial response. We sought to identify cytokines that can promote proliferation and induce or maintain IL-22 production by ILC3s and determine a molecular mechanism for this process. We identified IL-18 as a cytokine that cooperates with an ILC3 survival factor, IL-15, to induce proliferation of human ILC3s, as well as induce and maintain IL-22 production...
August 25, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
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