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https://www.readbyqxmd.com/read/28733440/dose-transition-pathways-the-missing-link-between-complex-dose-finding-designs-and-simple-decision-making
#1
Christina Yap, Lucinda J Billingham, Ying Kuen Cheung, Charlie Craddock, John O'Quigley
The ever increasing pace of development of novel therapies mandates efficient methodologies for assessment of their tolerability and activity. Evidence increasingly support the merits of model-based dose-finding designs in identifying the recommended Phase II dose compared to conventional rule-based designs such as the 3+3 but despite this, their use remains limited. Here, we propose a useful tool, Dose Transition Pathways (DTP), which helps overcome several commonly-faced practical and methodological challenges in the implementation of model-based designs...
July 21, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28732548/genome-wide-mapping-of-transcriptional-enhancer-candidates-using-dna-and-chromatin-features-in-maize
#2
Rurika Oka, Johan Zicola, Blaise Weber, Sarah N Anderson, Charlie Hodgman, Jonathan I Gent, Jan-Jaap Wesselink, Nathan M Springer, Huub C J Hoefsloot, Franziska Turck, Maike Stam
BACKGROUND: While most cells in multicellular organisms carry the same genetic information, in each cell type only a subset of genes is being transcribed. Such differentiation in gene expression depends, for a large part, on the activation and repression of regulatory sequences, including transcriptional enhancers. Transcriptional enhancers can be located tens of kilobases from their target genes, but display characteristic chromatin and DNA features, allowing their identification by genome-wide profiling...
July 21, 2017: Genome Biology
https://www.readbyqxmd.com/read/28727879/the-united-kingdom-sets-limits-on-experimental-treatments-the-case-of-charlie-gard
#3
Robert D Truog
No abstract text is available yet for this article.
July 20, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28724712/world-health-organisation-to-develop-global-action-plan-to-promote-physical-activity-time-for-action
#4
EDITORIAL
Charlie Foster, Trevor Shilton, Lucy Westerman, Justin Varney, Fiona Bull
No abstract text is available yet for this article.
July 19, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28724550/diet-and-exercise-in-pregnancy
#5
EDITORIAL
Marian Knight, Charlie Foster
No abstract text is available yet for this article.
July 19, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28724515/charlie-gard-case-an-ethicist-in-the-courtroom
#6
Daniel Sokol
No abstract text is available yet for this article.
July 19, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28723636/redox-dependent-modulation-of-metformin-contributes-to-enhanced-sensitivity-of-esophageal-squamous-cell-carcinoma-to-cisplatin
#7
Pin Dong Li, Zhao Liu, Tian Tian Cheng, Wen Guang Luo, Jing Yao, Jing Chen, Zhen Wei Zou, Li Li Chen, Charlie Ma, Xiao Fang Dai
Glutathione is the major intracellular anti-oxidant against reactive oxygen species and serves as a detoxification essential. The anti-diabetic drug metformin has been showed to exert anti-tumor activity via modulation of redox homeostasis. In this study, we provided evidence that metformin inhibits proliferation and induces apoptosis of esophageal squamous cancer cells. Importantly, we found that metformin acts as pro-oxidant via depletion of intracellular glutathione. Co-treatment with metformin reversed the elevated intracellular glutathione induced by cisplatin and therefore enhanced the sensitivity to cisplatin in vitro and in vivo...
July 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28719491/greater-effect-of-east-vs-west-travel-on-jet-lag-sleep-and-team-sport-performance
#8
Peter M Fowler, Wade Knez, Stephen Crowcroft, Amy E Mendham, Joanna Miller, Charlie Sargent, Shona Halson, Rob Duffield
PURPOSE: Determine the recovery timeline of sleep, subjective jet-lag and fatigue, and team-sport physical performance following east and west long-haul travel. METHODS: Ten, physically-trained males underwent testing at 09:00 (AM) and 17:00 (PM) local time on four consecutive days two weeks prior to outbound travel (BASE), and the first four days following 21 h of outbound (WEST) and return (EAST) air travel across eight time-zones between Australia and Qatar. Data collection included performance (countermovement jump [CMJ], 20-m sprint and Yo-Yo Intermittent Recovery level 1 [YYIR1] test) and perceptual (jet-lag, motivation, perceived exertion and physical feeling) measures...
July 17, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28718880/-i-just-don-t-want-to-connect-my-life-with-this-occupation-working-class-young-men-manual-labour-and-social-mobility-in-contemporary-russia
#9
Charlie Walker
A key strand in the Western literature on working-class masculinities focuses on whether young men are capable of the feminized performances apparently required of them in new service economies. However, the wider literature on processes of neoliberalization - emphasizing the 'hollowing out' of labour markets, the cultural devaluation of lower-skilled forms of employment, and the pathologization of working-class lives - would suggest that it is as much a classed as a gendered transformation that is demanded of young men leaving school with few qualifications...
July 18, 2017: British Journal of Sociology
https://www.readbyqxmd.com/read/28715361/trauma-systems-around-the-world-a-systematic-overview
#10
Suzan Dijkink, Charlie Nederpelt, Pieta Krijnen, George C Velmahos, Inger B Schipper
BACKGROUND: Implementation of trauma care systems has resulted in improved patient outcomes, but international differences obviously remain. Improvement of care can only be established if we recognize and clarify these differences. The aim of the current review is to provide an overview of the recent literature on the state of trauma systems globally. METHODS: The literature review over the period 2000-2016 was conducted following the PRISMA guidelines. Pre-hospital care, acute hospital care and quality assurance were classified using the WHO Trauma System Maturity Index in four levels from I (least mature) to IV (most mature)...
July 15, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28710741/eating-disorders-in-musicians-a-survey-investigating-self-reported-eating-disorders-of-musicians
#11
Marianna Evangelia Kapsetaki, Charlie Easmon
PURPOSE: This study aimed to estimate the prevalence of eating disorders (EDs) in musicians, and to evaluate their relation to perfectionism, stress, anxiety and depression. METHODS: It examined: (1) the prevalence of EDs using the Eating Disorder Examination Questionnaire (EDE-Q), body mass index (BMI) and self-reports, (2) psychological risk factors using the Depression Anxiety Stress Scale (DASS-21) and perfectionism inventory and (3) demographic details, information about musical and career development, lifestyle, eating habits and health...
July 14, 2017: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/28704796/prison-mental-health-in-reach-teams-serious-mental-illness-and-the-care-programme-approach-in-england
#12
Charlie Brooker, Russell Webster
The delivery of prison mental health services in England is examined over the last 12 years. Resources for services have grown significantly during this period and improved organisational models for the delivery of services are now in place. During this period however the challenges of working in the prison environment have increased. The paper argues that a history of sexual abuse or violence are common amongst prisoners and the Care Programme Approach (CPA) provides the vehicle to assess these histories through the use of routine enquiry...
July 5, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/28702908/water-quality-and-health-in-northern-canada-stored-drinking-water-and-acute-gastrointestinal-illness-in-labrador-inuit
#13
Carlee J Wright, Jan M Sargeant, Victoria L Edge, James D Ford, Khosrow Farahbakhsh, Inez Shiwak, Charlie Flowers, Sherilee L Harper
One of the highest self-reported incidence rates of acute gastrointestinal illness (AGI) in the global peer-reviewed literature occurs in Inuit communities in the Canadian Arctic. This high incidence of illness could be due, in part, to the consumption of contaminated water, as many northern communities face challenges related to the quality of municipal drinking water. Furthermore, many Inuit store drinking water in containers in the home, which could increase the risk of contamination between source and point-of-use (i...
July 12, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28697864/porous-coated-metaphyseal-sleeves-for-severe-femoral-and-tibial-bone-loss-in-revision-tka
#14
Tyler S Watters, John R Martin, Daniel L Levy, Charlie C Yang, Raymond H Kim, Douglas A Dennis
BACKGROUND: Metaphyseal bone loss is commonly encountered in revision total knee arthroplasty (TKA). Anderson Orthopaedic Research Institute types 2 and 3 defects generally require some form of metaphyseal fixation or augmentation. This study evaluates the midterm results of stepped, porous-coated metaphyseal sleeves in revision TKA in the setting of severe bone loss. METHODS: Patients who underwent revision TKA using metaphyseal sleeves from March 2006 to May 2014 at our institution were identified from a prospective research database...
June 20, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28690661/reliability-of-the-nicman-scale-an-instrument-to-assess-the-quality-of-acupuncture-administered-in-clinical-trials
#15
Caroline A Smith, Christopher J Zaslawski, Suzanne Cochrane, Xiaoshu Zhu, Zhen Zheng, Bertrand Loyeung, Peter C Meier, Sean Walsh, Charlie Changli Xue, Anthony L Zhang, Paul P Fahey, Alan Bensoussan
BACKGROUND: The aim of this study was to examine the reliability of a scale to assess the methodological quality of acupuncture administered in clinical research. METHODS: We invited 36 acupuncture researchers and postgraduate students to participate in the study. Firstly, participants rated two articles using the scale. Following this initial stage, modifications were made to scale items and the exercise was repeated. Interrater reliability was assessed for individual items using the Fleiss kappa statistic, whilst the overall scale used the intraclass correlation coefficient statistic...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28688999/assessing-the-implementation-of-a-bedside-service-handoff-on-an-academic-hospitalist-service
#16
Charlie M Wray, Vineet M Arora, Donald Hedeker, David O Meltzer
BACKGROUND: Inpatient service handoffs are a vulnerable transition during a patients' hospitalization. We hypothesized that performing the service handoff at the patients' bedside may be one mechanism to more efficiently transfer patient information between physicians, while further integrating the patient into their hospital care. METHODS: We performed a 6-month prospective study of performing a bedside handoff (BHO) at the service transition on a non-teaching hospitalist service...
July 5, 2017: Healthcare
https://www.readbyqxmd.com/read/28687648/host-specificity-of-segmented-filamentous-bacteria-sfb-flagellins-affects-their-interaction-patterns-with-mouse-ileal-mucosal-proteins
#17
Huahai Chen, Yeshi Yin, Yanling Wang, Xin Wang, Charlie Xiang
Segmented filamentous bacteria (SFB) are known modulators of the mammalian immune system. Currently, the technology for investigating SFB culture in vitro is immature, and as a result, the mechanisms of SFB colonization and immune regulation are not yet fully elucidated. In this study, we investigated the gene diversity and host specificity of SFB flagellin genes. The flic1 and flic2 genes are relatively conserved, while the flic3 and flic4 genes are more variable, especially at the central and C-terminal regions...
July 7, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28686528/the-vaginal-pressure-inducer-a-new-device-to-test-the-un-pleasurableness-and-tolerance-of-vaginal-pressure-and-the-influence-of-sexual-stimuli
#18
Reinhilde J Melles, Marieke D Dewitte, Moniek M Ter Kuile, Charlie Bonnemayer, Madelon M L Peters
To better understand the impact of sexual stimuli on genital pain, a new instrument was developed: the Vaginal Pressure Inducer (VPI). We administered gradually increasing vaginal pressure with the VPI to sexually functional women while watching a neutral, erotic or explicit sex film. Women had higher unpleasantness thresholds in a sexual context compared to a non-sexual context. Moreover, ratings of pleasurableness were higher in the sexual compared to neutral context and most so during the explicit sexual film...
July 7, 2017: Journal of Sex & Marital Therapy
https://www.readbyqxmd.com/read/28679380/a-novel-botanical-formula-prevents-diabetes-by-improving-insulin-resistance
#19
Juntao Kan, Rodney A Velliquette, Kerry Grann, Charlie R Burns, Jeff Scholten, Feng Tian, Qi Zhang, Min Gui
BACKGROUND: Type 2 diabetes mellitus (T2DM) is a major risk factor for cardiovascular disease, and the prevalence has increased significantly in recent decades to epidemic proportions in China. Individually, fenugreek (Trigonella foenum graecum) seed, mulberry (Morus alba L.) leaf and American ginseng (Panax quinquefolius) root can improve glycemia in various animal models and humans with impaired glucose metabolism and T2DM. The aim of this study was to design an optimized botanical formula containing these herbal extracts as a nutritional strategy for the prevention of insulin resistance and T2DM...
July 5, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28676496/law-ethics-and-emotion-the-charlie-gard-case
#20
Clare Dyer
No abstract text is available yet for this article.
July 4, 2017: BMJ: British Medical Journal
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