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https://www.readbyqxmd.com/read/28225555/pain-from-genes-and-proteins-to-cells-in-the-living-organism
#1
Charlie H T Kwok, Tuan Trang
No abstract text is available yet for this article.
February 22, 2017: Journal of Neuroscience Research
https://www.readbyqxmd.com/read/28224679/the-repeatability-of-tests-of-eustachian-tube-function-in-healthy-ears
#2
Matthew E Smith, Charlie C Zou, Charlotte Baker, Andrew J C Blythe, Peter J A Hutchinson, James R Tysome
OBJECTIVES/HYPOTHESIS: Many objective tests of eustachian tube (ET) function have been devised for clinical and research use but they have not been directly compared or characterized. As a first step to identifying tests to incorporate into an outcome set for ET dysfunction, we assessed repeatability of a panel of eight of these tests in healthy ears. STUDY DESIGN: Comparison of eight tests of ET function. METHODS: The following tests were investigated in combination with Valsalva, Toynbee, swallow, or sniff maneuvers: 1) patient-reported ET opening, 2) observed tympanic membrane movement, 3) continuous impedance, 4) canal manometry, 5) sonotubometry, 6) nine-step test, 7) tubomanometry, and 8) tympanometry at rest...
February 22, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28224486/human-herpes-virus-6-encephalitis-causing-severe-anterograde-amnesia-associated-with-rituximab-azathioprine-and-prednisolone-combination-therapy-for-dermatomyositis
#3
Thomas Baumer, Charlie Fry, Sebastian Luppe, Harsha Gunawardena, Kasia Sieradzan
Human herpes virus-6 (HHV-6) reactivation is a well-recognised complication following haematological stem cell transplantation, but it is novel in the context of combination immunomodulatory therapy for autoimmune disease. We report a case of severe anterograde amnesia caused by HHV-6 encephalitis in a young female patient on rituximab, azathioprine and prednisolone for dermatomyositis (DM). The use of targeted biologic treatments for systemic autoimmune connective tissue diseases (CTDs) is increasing, particularly when refractory to conventional management...
February 21, 2017: Journal of Neurovirology
https://www.readbyqxmd.com/read/28223274/long-term-responders-on-olaparib-maintenance-in-high-grade-serous-ovarian-cancer-clinical-and-molecular-characterization
#4
Stephanie Lheureux, Zhongwu Lai, Brian A Dougherty, Sarah Runswick, Darren Hodgson, Kirsten M Timms, Jerry S Lanchbury, Stanley B Kaye, Charlie Gourley, David D L Bowtell, Elise C Kohn, Clare L Scott, Ursula A Matulonis, Tony Panzarella, Katherine Karakasis, Julia V Burnier, Blake Gilks, Mark J O'Connor, Jane D Robertson, Jonathan Ledermann, J Carl Barrett, Tony W Ho, Amit M Oza
PURPOSE: Maintenance therapy with olaparib has improved progression-free survival in women with high-grade serous ovarian cancer (HGSOC), particularly those harboring BRCA1/2 mutations. The objective of this study was to characterize long-term (LT) versus short-term (ST) responders to olaparib. EXPERIMENTAL DESIGN: A comparative molecular analysis of Study 19 (NCT00753545), a randomized Phase II trial assessing olaparib maintenance after response to platinum-based chemotherapy in HGSOC, was conducted...
February 21, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28223154/idiopathic-and-systemic-sclerosis-associated-pulmonary-arterial-hypertension-a-comparison-of-demographic-haemodynamic-and-magnetic-resonance-imaging-characteristics-and-outcomes
#5
Sheila Ramjug, Nehal Hussain, Judith Hurdman, Catherine Billings, Athanasios Charampopoulos, Charlie A Elliot, David G Kiely, Ian Sabroe, Smitha Rajaram, Andrew J Swift, Robin Condliffe
BACKGROUND: Previous studies have identified survival in systemic sclerosis (SSc)-associated pulmonary arterial hypertension (SSc-PAH) to be worse than in idiopathic pulmonary arterial hypertension (IPAH). We investigated differences between these conditions by comparing demographic, haemodynamic and radiological characteristics and outcomes in a large cohort of incident patients. METHODS: 651 patients diagnosed with IPAH or SSc-associated pre-capillary pulmonary hypertension were included...
February 18, 2017: Chest
https://www.readbyqxmd.com/read/28220852/transfer-of-monolayer-tmd-ws2-and-raman-study-of-substrate-effects
#6
Jerome T Mlack, Paul Masih Das, Gopinath Danda, Yung-Chien Chou, Carl H Naylor, Zhong Lin, Néstor Perea López, Tianyi Zhang, Mauricio Terrones, A T Charlie Johnson, Marija Drndić
A facile transfer process for transition metal dichalcogenide WS2 flakes is reported and the effect of the underlying substrate on the flake properties is investigated using Raman spectroscopy. The flakes are transferred from their growth substrate using polymethyl methacrylate (PMMA) and a wet etch to allow the user to transfer the flakes to a final substrate using a microscope and micromanipulator combined with semi-transparent Kapton tape. The substrates used range from insulators such as industry standard high-k dielectric HfO2 and "green polymer" parylene-C, to conducting chemical vapor deposition (CVD) grown graphene...
February 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28219943/physical-activity-and-pregnancy-time-for-guidance-in-the-uk
#7
EDITORIAL
Hamish Reid, Ralph Smith, Catherine Calderwood, Charlie Foster
No abstract text is available yet for this article.
February 20, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28219714/relationship-between-physical-activity-and-hip-pain-in-persons-with-and-without-cam-or-pincer-morphology-a-population-based-case-control-study
#8
Jacek A Kopec, Jolanda Cibere, Linda C Li, Charlie Zhang, Morgan Barber, Hong Qian, Hubert Wong, Gavin Steininger, Helen Prlic, Jacqueline Simatovic, Charles Ratzlaff, Eric C Sayre, Joanna Ye, Bruce B Forster, John M Esdaile
OBJECTIVES: The purpose of the study was to determine if physical activity (PA) is a risk factor for persistent or recurrent hip pain in young and middle-aged persons with and without radiographic findings of cam or pincer morphology (CPM). METHODS: A population sample of persons aged 20-49 with (cases) and without (controls) hip pain in Metro Vancouver, Canada, was selected through random digit dialing. Self-reported PA was expressed as average energy expenditure (MET-hours) per year, over lifetime...
February 17, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28219685/development-of-a-chronic-disease-management-program-for-stroke-survivors-using-intervention-mapping-the-stroke-coach
#9
Brodie M Sakakibara, Scott A Lear, Susan I Barr, Oscar Benavente, Charlie H Goldsmith, Noah D Silverberg, Jennifer Yao, Janice J Eng
OBJECTIVE: To describe the systematic development of the Stroke Coach, a theory- and evidence-based intervention to improve control of lifestyle behaviour risk factors in stroke patients. DESIGN: Intervention development. SETTING: Community. PARTICIPANTS: Individuals who have had a stroke. INTERVENTION: We used Intervention Mapping to guide the development of the Stroke Coach. Intervention Mapping is a systematic process used for intervention development and comprised of steps that progress from the integration of theory and evidence to the organization of realistic strategies to facilitate the development of a practical intervention supported by empirical evidence...
February 17, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28209272/midterm-clinical-and-radiographic-results-of-mobile-bearing-revision-total-knee-arthroplasty
#10
Raymond H Kim, J Ryan Martin, Douglas A Dennis, Charlie C Yang, Jason M Jennings, Gwo-Chin Lee
BACKGROUND: Constrained implants are frequently required in revision total knee arthroplasty (TKA) and are associated with an increase in aseptic component loosening and damage or wear to the constraining mechanisms, compared with primary TKA. The purpose of the following study was to evaluate the midterm clinical and radiographic results including the incidence of bearing complications in a group of patients undergoing revision TKA using mobile-bearing revision TKA implants. METHODS: We retrospectively reviewed 316 consecutive mobile-bearing revision TKAs performed at 2 centers between 2006 and 2010...
January 20, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28208463/frequency-regulators-for-the-nonperturbative-renormalization-group-a-general-study-and-the-model-a-as-a-benchmark
#11
Charlie Duclut, Bertrand Delamotte
We derive the necessary conditions for implementing a regulator that depends on both momentum and frequency in the nonperturbative renormalization-group flow equations of out-of-equilibrium statistical systems. We consider model A as a benchmark and compute its dynamical critical exponent z. This allows us to show that frequency regulators compatible with causality and the fluctuation-dissipation theorem can be devised. We show that when the principle of minimal sensitivity (PMS) is employed to optimize the critical exponents η, ν, and z, the use of frequency regulators becomes necessary to make the PMS a self-consistent criterion...
January 2017: Physical Review. E
https://www.readbyqxmd.com/read/28198672/integrated-metagenomic-data-analysis-demonstrates-that-a-loss-of-diversity-in-oral-microbiota-is-associated-with-periodontitis
#12
Dongmei Ai, Ruocheng Huang, Jin Wen, Chao Li, Jiangping Zhu, Li Charlie Xia
BACKGROUND: Periodontitis is an inflammatory disease affecting the tissues supporting teeth (periodontium). Integrative analysis of metagenomic samples from multiple periodontitis studies is a powerful way to examine microbiota diversity and interactions within host oral cavity. METHODS: A total of 43 subjects were recruited to participate in two previous studies profiling the microbial community of human subgingival plaque samples using shotgun metagenomic sequencing...
January 25, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28193397/socioeconomic-status-and-non-communicable-disease-behavioural-risk-factors-in-low-income-and-lower-middle-income-countries-a-systematic-review
#13
Luke Allen, Julianne Williams, Nick Townsend, Bente Mikkelsen, Nia Roberts, Charlie Foster, Kremlin Wickramasinghe
BACKGROUND: Non-communicable diseases are the leading global cause of death and disproportionately afflict those living in low-income and lower-middle-income countries (LLMICs). The association between socioeconomic status and non-communicable disease behavioural risk factors is well established in high-income countries, but it is not clear how behavioural risk factors are distributed within LLMICs. We aimed to systematically review evidence on the association between socioeconomic status and harmful use of alcohol, tobacco use, unhealthy diets, and physical inactivity within LLMICs...
March 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28190786/survival-in-portopulmonary-hypertension-outcomes-of-the-united-kingdom-national-pulmonary-arterial-hypertension-registry
#14
Sasiharan Sithamparanathan, Arun Nair, Logan Thirugnanasothy, J Gerry Coghlan, Robin Condliffe, Konstantinos Dimopoulos, Charlie A Elliot, Andrew J Fisher, Sean Gaine, J Simon R Gibbs, Michael A Gatzoulis, Clive E Handler, Luke S Howard, Martin Johnson, David G Kiely, James L Lordan, Andrew J Peacock, Joanna Pepke-Zaba, Benjamin E Schreiber, Karen K K Sheares, Stephen J Wort, Paul A Corris
BACKGROUND: Portopulmonary hypertension (PoPH) is a rare condition associated with poor survival, and the effect of modern therapies that target pulmonary arterial hypertension (PAH) on long-term outcome is unknown. This study investigated the baseline characteristics and survival in the cohort of patients diagnosed with PoPH in the United Kingdom National Pulmonary Hypertension Service. METHODS: A retrospective review was conducted of all incident treatment-naïve patients with PoPH within the United Kingdom national registry diagnosed between January 2001 and December 2010...
December 31, 2016: Journal of Heart and Lung Transplantation
https://www.readbyqxmd.com/read/28187822/editorial-commentary-on-toolbox-of-multi-item-measures-aligning-with-icf-core-sets-for-children-and-youth-with-cerebral-palsy
#15
EDITORIAL
Charlie Fairhurst
No abstract text is available yet for this article.
March 2017: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/28187718/an-education-programme-influencing-health-professionals-to-recommend-exercise-to-their-type-2-diabetes-patients-understanding-the-processes-a-case-study-from-oxfordshire-uk
#16
Anne Matthews, Natasha Jones, Alastair Thomas, Perdy van den Berg, Charlie Foster
BACKGROUND: Increasing levels of physical activity decreases the risk of premature mortality associated with chronic diseases e.g., coronary heart disease, type 2 diabetes, stroke. Despite this, most adults in England do not meet physical activity guidelines. Physical activity advice and signposting offered to at-risk patients by primary care providers is recommended. However, exercise medicine education is sparse, leading to poor practitioner knowledge of the risk reduction evidence and strategies to implement effective patient behaviour change...
February 11, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28187238/evolutionary-associations-between-host-traits-and-parasite-load-insights-from-lake-tanganyika-cichlids
#17
Alexander Hayward, Masahito Tsuboi, Christian Owusu, Alexander Kotrschal, Séverine D Buechel, Josefina Zidar, Charlie K Cornwallis, Hanne Løvlie, Niclas Kolm
Parasite diversity and abundance (parasite load) vary greatly among host species. However, the influence of host traits on variation in parasitism remains poorly understood. Comparative studies of parasite load have largely examined measures of parasite species richness, and are predominantly based on records obtained from published data. Consequently, little is known about the relationships between host traits and other aspects of parasite load, such as parasite abundance, prevalence, and aggregation. Meanwhile, understanding of parasite species richness may be clouded by limitations associated with data collation from multiple independent sources...
February 10, 2017: Journal of Evolutionary Biology
https://www.readbyqxmd.com/read/28182696/ontogenetic-comparisons-of-standard-metabolism-in-three-species-of-crocodilians
#18
C M Gienger, Matthew L Brien, Christopher R Tracy, S Charlie Manolis, Grahame J W Webb, Roger S Seymour, Keith A Christian
Due in part to their large size, aggressive temperament, and difficulty in handling, there are few physiological studies of adult crocodilians in the literature. As a result, studies comparing individuals across an ontogenetic series and comparisons among species are also lacking. We addressed this gap in knowledge by measuring standard metabolic rates (SMR) of three species of crocodilians (Crocodylus porosus, C. johnsoni, and Alligator mississippiensis), and included individuals that ranged from 0.22 to 114 kg...
2017: PloS One
https://www.readbyqxmd.com/read/28179259/the-associations-between-participation-in-certain-sports-and-lower-mortality-are-not-explained-by-affluence-and-other-socioeconomic-factors
#19
EDITORIAL
Emmanuel Stamatakis, Paul Kelly, Sylvia Titze, Zeljko Pedisic, Adrian Bauman, Charlie Foster, Mark Hamer, Melvyn Hillsdon, Pekka Oja
No abstract text is available yet for this article.
February 8, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28170197/enhanced-cardioprotection-by-human-endometrium-mesenchymal-stem-cells-driven-by-exosomal-microrna-21
#20
Kan Wang, Zhi Jiang, Keith A Webster, Jinghai Chen, Hengxun Hu, Yu Zhou, Jing Zhao, Lihan Wang, Yingchao Wang, Zhiwei Zhong, Cheng Ni, Qingju Li, Charlie Xiang, Ling Zhang, Rongrong Wu, Wei Zhu, Hong Yu, Xinyang Hu, Jian'an Wang
Our group recently reported positive therapeutic benefit of human endometrium-derived mesenchymal stem cells (EnMSCs) delivered to infarcted rat myocardium, an effect that correlated with enhanced secretion of protective cytokines and growth factors compared with parallel cultures of human bone marrow MSCs (BMMSCs). To define more precisely the molecular mechanisms of EnMSC therapy, in the present study, we assessed in parallel the paracrine and therapeutic properties of MSCs derived from endometrium, bone marrow, and adipose tissues in a rat model of myocardial infarction (MI)...
January 2017: Stem Cells Translational Medicine
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