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https://www.readbyqxmd.com/read/28333140/metabolic-and-molecular-insights-into-an-essential-role-of-nicotinamide-phosphoribosyltransferase
#1
Li Q Zhang, Leon Van Haandel, Min Xiong, Peixin Huang, Daniel P Heruth, Charlie Bi, Roger Gaedigk, Xun Jiang, Ding-You Li, Gerald Wyckoff, Dmitry N Grigoryev, Li Gao, Linheng Li, Min Wu, J Steven Leeder, Shui Qing Ye
Nicotinamide phosphoribosyltransferase (NAMPT) is a pleiotropic protein implicated in the pathogenesis of acute respiratory distress syndrome, aging, cancer, coronary heart diseases, diabetes, nonalcoholic fatty liver disease, obesity, rheumatoid arthritis, and sepsis. However, the underlying molecular mechanisms of NAMPT in these physiological and pathological processes are not fully understood. Here, we provide experimental evidence that a Nampt gene homozygous knockout (Nampt(-/-)) resulted in lethality at an early stage of mouse embryonic development and death within 5-10 days in adult mice accompanied by a 25...
March 23, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28330189/defense-response-enhancement-in-strawberry-via-elicitors
#2
Gihan M H Hussein, Tahany M A Abdel-Rahman, A H Alwan
In this study, cell-suspension culture of strawberry (Fragaria × ananassa), cultivars Camarosa, and Sweet Charlie has been established. Embryogenic callus was induced by incubating the in vitro juvenile leaf explants on medium, containing 2-mg/l picloram at dark. Suspension culture was initiated from 4-week-old embryogenic calli in the liquid MS medium with 1-mg/l 2,4-D and 2-mg/l picloram. Suspension culture was maintained by sub-culturing each 3 weeks into a fresh medium. At week 9 after third sub-cultures, torpedo and cotyledonary embryo stages were observed...
December 2016: 3 Biotech
https://www.readbyqxmd.com/read/28329715/psychological-distress-and-prejudice-following-terror-attacks-in-france
#3
Robin Goodwin, Krzysztof Kaniasty, Shaojing Sun, Menachem Ben-Ezra
Terrorist attacks have the capacity to threaten our beliefs about the world, cause distress across populations and promote discrimination towards particular groups. We examined the impact of two different types of attacks in the same city and same year on psychological distress and probable posttraumatic stress symptoms, and the moderating effects of religion or media use on distress/posttraumatic symptoms and inter-group relations. Two panel surveys four weeks after the January 2015 Charlie Hebdo attack (N = 1981) and the November 2015 Bataclan concert hall/restaurant attacks (N = 1878), measured intrinsic religiosity, social and traditional media use, psychological distress (K6), probable posttraumatic stress symptoms (proposed ICD-11), symbolic racism and willingness to interact with Muslims by non-Muslims...
March 16, 2017: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/28328237/magnetic-resonance-imaging-in-the-prognostic-evaluation-of-patients-with-pulmonary-arterial-hypertension
#4
Andrew J Swift, Dave Capener, Chris Johns, Neil Hamilton, Alex Rothman, Charlie Elliot, Robin Condliffe, Athanasios Charalampopoulos, Smitha Rajaram, Allan Lawrie, Michael J Campbell, Jim M Wild, David G Kiely
RATIONALE: Prognostication is important when counselling patients and defining treatment strategies in pulmonary arterial hypertension (PAH). OBJECTIVE: To determine the value of MRI metrics for prediction of mortality in PAH. METHODS: Consecutive patients with PAH undergoing MRI were identified from the ASPIRE-Pulmonary-Hypertension-Registry. MEASUREMENTS AND MAIN RESULTS: During the follow-up period of 42 (range 17-142) months 576 patients were studied and 221 (38%) died...
March 22, 2017: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/28320080/interlaboratory-trial-for-the-measurement-of-total-cobalt-in-equine-urine-and-plasma-by-icp-ms
#5
Marie-Agnes Popot, Emmie N M Ho, Natali Stojiljkovic, Florian Bagilet, Pierre Remy, Pascal Maciejewski, Benoit Loup, George H M Chan, Sabine Hargrave, Rick M Arthur, Charlie Russo, James White, Pamela Hincks, Clive Pearce, George Ganio, Paul Zahra, David Batty, Mark Jarrett, Lydia Brooks, Lise-Anne Prescott, Ludovic Bailly-Chouriberry, Yves Bonnaire, Terence S M Wan
Cobalt is an essential mineral micronutrient and is regularly present in equine nutritional and feed supplements. Therefore, cobalt is naturally present at low concentrations in biological samples. The administration of cobalt chloride is considered to be blood doping and is thus prohibited. In order to control the misuse of cobalt, it was mandatory to establish an international threshold for cobalt in plasma and/or in urine. To achieve this goal an international collaboration, consisting of an interlaboratory comparison, between 5 laboratories for the urine study and 8 laboratories for the plasma study has been undertaken...
March 20, 2017: Drug Testing and Analysis
https://www.readbyqxmd.com/read/28315351/-3-h-bmt-046091-a-potent-and-selective-radioligand-to-determine-aak1-distribution-and-target-engagement
#6
Justin V Louis, Yifeng Lu, Rick Pieschl, Yung Tian, Yang Hong, Kumaran Dandapani, Sreenivasulu Naidu, Reeba K Vikramadithyan, Carolyn Dzierba, Sarat Kumar Sarvasiddhi, Susheel J Nara, Joanne Bronson, John E Macor, Charlie Albright, Walter Kostich, Yu-Wen Li
Adaptor-associated kinase 1 (AAK1), a member of the Ark1/Prk1 family of serine/threonine kinases, plays a role in modulating clatherin coated endocytosis of specific surface receptors. We have demonstrated that AAK1 inhibitors are efficacious in rodent models of neuropathic pain (Kostich et al., 2016). Here we have characterized the binding properties and distribution pattern of the tritiated AAK1 radioligand, [(3)H]BMT-046091, in rodents and cynomolgus monkeys, and used the radioligand to measure the brain target occupancy following systemic administration of AAK1 inhibitors...
March 14, 2017: Neuropharmacology
https://www.readbyqxmd.com/read/28306652/tests-of-eustachian-tube-function-the-effect-of-testing-technique-on-tube-opening-in-healthy-ears
#7
Matthew E Smith, Andrew J C Blythe, Charlotte Baker, Charlie C Zou, Peter J A Hutchinson, James R Tysome
OBJECTIVE: There is no agreement on the best clinical test for Eustachian tube (ET) dysfunction. Numerous tests have been developed to detect ET opening, and all require a patient to perform a Valsalva, Toynbee or sniff maneuver, or to swallow on demand. We aimed to characterize existing tests of ET function in healthy ears, and identify the optimal method and patient maneuver for each test. Our own normative data is presented alongside published comparisons. STUDY DESIGN: Diagnostic test cohort study...
March 16, 2017: Otology & Neurotology
https://www.readbyqxmd.com/read/28301362/analysis-of-surfing-injuries-presenting-in-the-acute-trauma-setting
#8
Kevin T Jubbal, Charlie Chen, Todd Costantini, Fernando Herrera, Marek Dobke, Ahmed Suliman
BACKGROUND AND PURPOSE: Surfing is a rapidly growing major worldwide sport; however, little is understood regarding severe injuries and resulting hospital admissions. This study explores surfing-related injuries in the major surfing hub of San Diego presenting in the acute trauma setting. The purpose of this study is to address the void of information regarding severe surfing injuries in the trauma setting, including injury patterns, associated hospitalization course, and risk factors...
March 16, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28300161/foxo-transcription-factors-protect-against-the-diet-induced-fatty-liver-disease
#9
Xiaoyan Pan, Yang Zhang, Hyeong-Geug Kim, Suthat Liangpunsakul, X Charlie Dong
Forkhead O transcription factors (FOXOs) have been implicated in glucose and lipid homeostasis; however, the role of FOXOs in the development of nonalcoholic fatty liver disease (NAFLD) is not well understood. In this study, we designed experiments to examine the effects of two different diets-very high fat diet (HFD) and moderately high fat plus cholesterol diet (HFC)-on wildtype (WT) and liver-specific Foxo1/3/4 triple knockout mice (LTKO). Both diets induced severe hepatic steatosis in the LTKO mice as compared to WT controls...
March 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28299535/the-self-in-movement-being-identified-and-identifying-oneself-in-the-process-of-migration-and-asylum-seeking
#10
Meike Watzlawik, Ignacio Brescó de Luna
How migration influences the processes of identity development has been under longstanding scrutiny in the social sciences. Usually, stage models have been suggested, and different strategies for acculturation (e.g., integration, assimilation, separation, and marginalization) have been considered as ways to make sense of the psychological transformations of migrants as a group. On an individual level, however, identity development is a more complex endeavor: Identity does not just develop by itself, but is constructed as an ongoing process...
March 15, 2017: Integrative Psychological & Behavioral Science
https://www.readbyqxmd.com/read/28295552/high-resolution-dynamic-oxygen-17-mr-imaging-of-mouse-brain-with-golden-ratio-based-radial-sampling-and-k-space-weighted-image-reconstruction
#11
Yuchi Liu, Yifan Zhang, Chunying Wu, Junqing Zhu, Charlie Wang, Nicholas Tomko, Mikhail D Linetsky, Robert G Salomon, Ciro Ramos-Estebanez, Yanming Wang, Xin Yu
PURPOSE: The current study aimed to develop a three-dimensional (3D) dynamic oxygen-17 ((17) O) MR imaging method with high temporal and spatial resolution to delineate the kinetics of (17) O water uptake and washout in the brains of mice with glioblastoma (GBM). METHODS: A 3D imaging method with a stack-of-stars golden-ratio-based radial sampling scheme was employed to acquire (17) O signal in vivo. A k-space-weighted image reconstruction method was used to improve the temporal resolution while preserving spatial resolution...
March 13, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28289261/growth-rate-transmission-mode-and-virulence-in-human-pathogens
#12
Helen C Leggett, Charlie K Cornwallis, Angus Buckling, Stuart A West
The harm that pathogens cause to hosts during infection, termed virulence, varies across species from negligible to a high likelihood of rapid death. Classic theory for the evolution of virulence is based on a trade-off between pathogen growth, transmission and host survival, which predicts that higher within-host growth causes increased transmission and higher virulence. However, using data from 61 human pathogens, we found the opposite correlation to the expected positive correlation between pathogen growth rate and virulence...
May 5, 2017: Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
https://www.readbyqxmd.com/read/28284439/when-age-progressed-images-are-unreliable-the-roles-of-external-features-and-age-range
#13
William Blake Erickson, James Michael Lampinen, Charlie D Frowd, Gregory Mahoney
When children go missing for many years, investigators commission age-progressed images from forensic artists to depict an updated appearance. These images have anecdotal success, and systematic research has found they lead to accurate recognition rates comparable to outdated photos. The present study examines the reliability of age progressions of the same individuals created by different artists. Eight artists first generated age progressions of eight targets across three age ranges. Eighty-five participants then evaluated the similarity of these images against other images depicting the same targets progressed at the same age ranges, viewing either whole faces or faces with external features concealed...
March 2017: Science & Justice: Journal of the Forensic Science Society
https://www.readbyqxmd.com/read/28282243/differences-in-right-ventricular-functional-changes-during-treatment-between-systemic-sclerosis-associated-pulmonary-arterial-hypertension-and-idiopathic-pulmonary-arterial-hypertension
#14
Rahul G Argula, Abhijit Karwa, Abigail Lauer, David Gregg, Richard M Silver, Carol Feghali-Bostwick, Lynn M Schnapp, Kim Egbert, Bruce W Usher, Viswanathan Ramakrishnan, Paul M Hassoun, Charlie Strange
RATIONALE: Patients with scleroderma associated pulmonary arterial hypertension (SSc-PAH) continue to have an unacceptably high mortality despite the progress achieved with pulmonary arterial vasodilator therapies. OBJECTIVES: We sought to determine whether SSc-PAH is a clinically distinct pulmonary vascular disease phenotype when compared to IPAH, based on the progression of echocardiographic right ventricular (RV) dysfunction. METHODS: Retrospective analysis of echocardiographic data in 13 SSc-PAH and 11 IPAH patients was used to delineate the progression of RV dysfunction during single or combination pulmonary arterial vasodilator therapy...
March 10, 2017: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/28267239/the-transcriptome-of-the-avian-malaria-parasite-plasmodium-ashfordi-displays-host-specific-gene-expression
#15
Elin Videvall, Charlie K Cornwallis, Dag Ahrén, Vaidas Palinauskas, Gediminas Valkiūnas, Olof Hellgren
Malaria parasites (Plasmodium spp.) include some of the world's most widespread and virulent pathogens. Our knowledge of the molecular mechanisms these parasites use to invade and exploit hosts other than mice and primates is, however, extremely limited. It is therefore imperative to characterize transcriptome-wide gene expression from non-model malaria parasites and how this varies across host individuals. Here, we used high-throughput Illumina RNA-sequencing on blood from wild-caught Eurasian siskins experimentally infected with a clonal strain of the avian malaria parasite Plasmodium ashfordi (lineage GRW2)...
March 7, 2017: Molecular Ecology
https://www.readbyqxmd.com/read/28259974/3-hydroxyterphenyllin-a-natural-fungal-metabolite-induces-apoptosis-and-s-phase-arrest-in-human-ovarian-carcinoma-cells
#16
Yaomin Wang, Casey Compton, Gary O Rankin, Stephen J Cutler, Yon Rojanasakul, Youying Tu, Yi Charlie Chen
In the present study, we evaluated 3-Hydroxyter-phenyllin (3-HT) as a potential anticancer agent using the human ovarian cancer cells A2780/CP70 and OVCAR-3, and normal human epithelial ovarian cells IOSE-364 as an in vitro model. 3-HT suppressed proliferation and caused cytotoxicity against A2780/CP70 and OVCAR-3 cells, while it exhibited lower cytotoxicity in IOSE-364 cells. Subsequently, we found that 3-HT induced S phase arrest and apoptosis in a dose-independent manner. Further investigation revealed that S phase arrest was related with DNA damage which mediated the ATM/p53/Chk2 pathway...
March 2, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28258175/infographic-health-benefits-of-specific-types-of-sports
#17
EDITORIAL
Pekka Oja, Paul Kelly, Zeljko Pedisic, Sylvia Titze, Adrian E Bauman, Charlie Foster, Mark Hamer, Melvyn Hillsdon, Emmanuel Stamatakis
No abstract text is available yet for this article.
March 3, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28254623/future-climate-change-scenarios-differentially-affect-three-abundant-algal-species-in-southwestern-australia
#18
Charlie M Phelps, Mary C Boyce, Megan J Huggett
Three species of macroalgae (Ecklonia radiata, Sargassum linearifolium, and Laurencia brongniartii) were subjected to future climate change conditions, tested directly for changes in their physiology and chemical ecology, and used in feeding assays with local herbivores to identify the indirect effects of climatic stressors on subsequent levels of herbivory. Each alga had distinct physical and chemical responses to the changes in environmental conditions. In high temperature conditions, S. linearifolium exhibited high levels of bleaching and low maximum quantum yield...
February 21, 2017: Marine Environmental Research
https://www.readbyqxmd.com/read/28248499/heterocyclyl-tetracyclines-1-7-trifluoromethyl-8-pyrrolidinyltetracyclines-potent-broad-spectrum-antibacterial-agents-with-enhanced-activity-against-pseudomonas-aeruginosa
#19
Yonghong Deng, Cuixiang Sun, Diana K Hunt, Corey Fyfe, Chi-Li Chen, Trudy H Grossman, Joyce A Sutcliffe, Xiao-Yi Xiao
Utilizing a total synthesis approach, the first 8-heterocyclyltetracyclines were designed, synthesized, and evaluated against panels of tetracycline- and multidrug-resistant Gram-positive and Gram-negative pathogens. Several compounds with balanced, highly potent in vitro activity against a broad range of bacterial isolates were identified through structure-activity relationships (SAR) studies. One compound demonstrated the best antibacterial activity against Pseudomonas aeruginosa both in vitro and in vivo for tetracyclines reported to date...
March 15, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28245686/analyzing-cost-effectiveness-of-ulnar-and-median-nerve-transfers-to-regain-forearm-flexion
#20
Arvin R Wali, Charlie C Park, Justin M Brown, Ross Mandeville
OBJECTIVE Peripheral nerve transfers to regain elbow flexion via the ulnar nerve (Oberlin nerve transfer) and median nerves are surgical options that benefit patients. Prior studies have assessed the comparative effectiveness of ulnar and median nerve transfers for upper trunk brachial plexus injury, yet no study has examined the cost-effectiveness of this surgery to improve quality-adjusted life years (QALYs). The authors present a cost-effectiveness model of the Oberlin nerve transfer and median nerve transfer to restore elbow flexion in the adult population with upper brachial plexus injury...
March 2017: Neurosurgical Focus
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