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https://www.readbyqxmd.com/read/28532986/improving-value-by-reducing-unnecessary-telemetry-and-urinary-catheter-utilization-in-hospitalized-patients
#1
Charlie M Wray, John Fahrenbach, Nikhil Bassi, Poushali Bhattacharjee, Matthew Modes, Michael D Howell, Vineet M Arora
No abstract text is available yet for this article.
May 19, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/28531308/challenges-of-research-recruitment-in-a-university-setting-in-england
#2
Claudia Vadeboncoeur, Charlie Foster, Nick Townsend
The recruitment is an integral part of most research projects in medical sciences involving human participants. In health promotion research, there is increasing work on the impact of environments. Settings represent environments such as schools where social, physical and psychological development unfolds. In this study, we investigated weight gain in students within a university setting. Barriers to access and recruitment of university students within a specific setting, in the context of health research are discussed...
May 20, 2017: Health Promotion International
https://www.readbyqxmd.com/read/28529804/unilateral-discomfort-increases-the-use-of-contralateral-side-during-sit-to-stand-transfer
#3
Simisola O Oludare, Charlie C Ma, Alexander S Aruin
Individuals with unilateral impairment perform symmetrical movements asymmetrically. Restoring symmetry of movements is an important goal of rehabilitation. The aim of the study was to evaluate the effect of using discomfort-inducing devices on movement symmetry. Fifteen healthy individuals performed the sit-to-stand (STS) maneuver using devices inducing unilateral discomfort under the left sole and left thigh or right sole and right thigh and without them. 3D body kinematics, ground reaction forces, electrical activity of muscles, and the level of perceived discomfort were recorded...
2017: Rehabilitation Research and Practice
https://www.readbyqxmd.com/read/28529565/prodelphinidins-isolated-from-chinese-bayberry-leaves-induces-apoptosis-via-the-p53-dependent-signaling-pathways-in-ovcar-3-human-ovarian-cancer-cells
#4
Yu Fu, Xingqian Ye, Malcolm Lee, Gary Rankin, Yi Charlie Chen
Chinese bayberry leaves are rich in prodelphinidins. Since the isolation and purification of prodelphinidins is difficult, the association between the degree of prodelphinidin polymerization and their anti-carcinogenic activity remains ambiguous. The cytotoxic and apoptotic activities of prodelphinidin Chinese bayberry leaf extracts (PCBLs), oligomeric proanthocyanidins (OPAs) and polymeric proanthocyanidins (PPAs), isolated by normal-phase preparative high-performance liquid chromatography were investigated in OVCAR-3 human ovarian cancer cells...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28527344/harnessing-plant-metabolic-diversity
#5
REVIEW
Charlie Owen, Nicola J Patron, Ancheng Huang, Anne Osbourn
Advances in DNA sequencing and synthesis technologies in the twenty-first century are now making it possible to build large-scale pipelines for engineering plant natural product pathways into heterologous production species using synthetic biology approaches. The ability to decode the chemical potential of plants by sequencing their transcriptomes and/or genomes and to then use this information as an instruction manual to make drugs and other high-value chemicals is opening up new routes to harness the vast chemical diversity of the Plant Kingdom...
May 17, 2017: Current Opinion in Chemical Biology
https://www.readbyqxmd.com/read/28525846/exploring-the-clonal-evolution-of-cd133-aldehyde-dehydrogenase-1-aldh1-positive-cancer-stem-like-cells-from-primary-to-recurrent-high-grade-serous-ovarian-cancer-hgsoc-a-study-of-the-ovarian-cancer-therapy-innovative-models-prolong-survival-octips-consortium
#6
Ilary Ruscito, Dan Cacsire Castillo-Tong, Ignace Vergote, Iulia Ignat, Mandy Stanske, Adriaan Vanderstichele, Ram N Ganapathi, Jacek Glajzer, Hagen Kulbe, Fabian Trillsch, Alexander Mustea, Caroline Kreuzinger, Pierluigi Benedetti Panici, Charlie Gourley, Hani Gabra, Mirjana Kessler, Jalid Sehouli, Silvia Darb-Esfahani, Elena Ioana Braicu
BACKGROUND: High-grade serous ovarian cancer (HGSOC) causes 80% of all ovarian cancer (OC) deaths. In this setting, the role of cancer stem-like cells (CSCs) is still unclear. In particular, the evolution of CSC biomarkers from primary (pOC) to recurrent (rOC) HGSOCs is unknown. Aim of this study was to investigate changes in CD133 and aldehyde dehydrogenase-1 (ALDH1) CSC biomarker expression in pOC and rOC HGSOCs. METHODS: Two-hundred and twenty-four pOC and rOC intrapatient paired tissue samples derived from 112 HGSOC patients were evaluated for CD133 and ALDH1 expression using immunohistochemistry (IHC); pOCs and rOCs were compared for CD133 and/or ALDH1 levels...
May 16, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28524458/forelimb-myology-of-carnivorous-marsupials-marsupialia-dasyuridae-implications-for-the-ancestral-body-plan-of-the-australidelphia
#7
Natalie M Warburton, Charlie-Rose Marchal
Carnivorous marsupials of the family Dasyuridae represent a more generalized anatomical condition of both craniodental and postcranial features in comparison to other groups of Australidelphian marsupials. Plesiomorphic characters include polyprotodont dentition, didactylous (rather than syndactylous) pedal morphology, the retention of clavicles and epipubic bones, and an unossified patelloid. In light of the anatomy of the postcranial skeleton, we hypothesized that the muscular anatomy of the Dasyuridae would likely display a range of plesiomorphic traits...
May 19, 2017: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/28521297/human-menstrual-blood-derived-mesenchymal-stem-cells-as-a-cellular-vehicle-for-malignant-glioma-gene-therapy
#8
Xiao-Jun Wang, Bing-Yu Xiang, Ya-Hui Ding, Lu Chen, Hai Zou, Xiao-Zhou Mou, Charlie Xiang
Despite many advances in conventional treatment strategies, there is no effective treatment modality for malignant gliomas. Gene therapy may offer a promising option for gliomas and several gene therapy approaches have shown anti-tumor efficiency in previous studies. Mesenchymal stem cell-based gene therapies, in which stem cells are genetically engineered to express therapeutic molecules, have shown tremendous potential because of their innate homing ability. In this study, human menstrual blood-derived MSCs (MenSC), a novel type of multipotential MSCs displays tropism for human malignant glioma when used as a gene delivery vehicle for therapeutics...
May 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28516308/the-charlie-sheen-effect-on-rapid-in-home-human-immunodeficiency-virus-test-sales
#9
Jon-Patrick Allem, Eric C Leas, Theodore L Caputi, Mark Dredze, Benjamin M Althouse, Seth M Noar, John W Ayers
One in eight of the 1.2 million Americans living with human immunodeficiency virus (HIV) are unaware of their positive status, and untested individuals are responsible for most new infections. As a result, testing is the most cost-effective HIV prevention strategy and must be accelerated when opportunities are presented. Web searches for HIV spiked around actor Charlie Sheen's HIV-positive disclosure. However, it is unknown whether Sheen's disclosure impacted offline behaviors like HIV testing. The goal of this study was to determine if Sheen's HIV disclosure was a record-setting HIV prevention event and determine if Web searches presage increases in testing allowing for rapid detection and reaction in the future...
May 18, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28515227/frontline-science-eosinophil-deficient-mbp-1-and-epx-double-knockout-mice-link-pulmonary-remodeling-and-airways-dysfunction-with-type-2-inflammation
#10
Sergei I Ochkur, Alfred D Doyle, Elizabeth A Jacobsen, William E LeSuer, Wen Li, Cheryl A Protheroe, Katie R Zellner, Dana Colbert, HuaHao H Shen, Charlie G Irvin, James J Lee, Nancy A Lee
Eosinophils and the release of cationic granule proteins have long been implicated in the development of the type 2-induced pathologies linked with respiratory inflammation. Paradoxically, the ablation of the two genes encoding the most abundant of these granule proteins, major basic protein-1 (MBP-1) and eosinophil peroxidase (EPX), results in a near collapse of eosinophilopoiesis. The specificity of this lineage ablation and the magnitude of the induced eosinopenia provide a unique opportunity to clarify the importance of eosinophils in acute and chronic inflammatory settings, as well as to identify potential mechanism(s) of action linked with pulmonary eosinophils in those settings...
May 17, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28508452/mental-health-cost-of-terrorism-study-of-the-charlie-hebdo-attack-in-paris
#11
Dongyoung Kim, Young-I Albert Kim
This study examines whether a terrorist attack in a developed country, which does not cause major damage to its capital stocks, affects the mental health of its residents. By exploiting variations in survey dates of the European Social Survey, we use a difference-in-differences strategy to show that the attack adversely affects subjective well-being and mental health measures of French respondents. These negative effects are stronger for immigrants and low-income individuals. The impact is less dramatic for politically extreme right-wing supporters...
May 15, 2017: Health Economics
https://www.readbyqxmd.com/read/28500416/effects-of-breaking-up-prolonged-sitting-following-low-and-high-glycaemic-index-breakfast-consumption-on-glucose-and-insulin-concentrations
#12
Daniel P Bailey, Benjamin D Maylor, Charlie J Orton, Julia K Zakrzewski-Fruer
PURPOSE: Breaking up prolonged sitting can attenuate the postprandial rise in glucose and insulin. Whether such effects are dependent of the glycaemic index (GI) of the consumed carbohydrate is unknown. This study examined the acute effects of breaking up prolonged sitting following a low GI and a high GI breakfast on postprandial glucose and insulin concentrations. PROCEDURES: Fourteen adult males aged 22.1 ± 1.2 years completed four, 4 h experimental conditions: high GI breakfast followed by uninterrupted sitting (HGI-SIT), low GI breakfast followed by uninterrupted sitting (LGI-SIT), high GI breakfast followed by 2 min activity breaks every 20 min (HGI-ACT), and low GI breakfast followed by 2 min activity breaks every 20 min (LGI-ACT)...
May 12, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28493376/evaluation-of-the-angiotensin-ii-receptor-blocker-azilsartan-medoxomil-in-african-american-patients-with-hypertension
#13
Wallace Johnson, William B White, Domenic Sica, George L Bakris, Michael A Weber, Alison Handley, Alfonso Perez, Charlie Cao, Stuart Kupfer, Elijah B Saunders
The efficacy and safety of azilsartan medoxomil (AZL-M) were evaluated in African-American patients with hypertension in a 6-week, double-blind, randomized, placebo-controlled trial, for which the primary end point was change from baseline in 24-hour mean systolic blood pressure (BP). There were 413 patients, with a mean age of 52 years, 57% women, and baseline 24-hour BP of 146/91 mm Hg. Treatment differences in 24-hour systolic BP between AZL-M 40 mg and placebo (-5.0 mm Hg; 95% confidence interval, -8...
May 11, 2017: Journal of Clinical Hypertension
https://www.readbyqxmd.com/read/28490195/the-takei-handheld-dynamometer-an-effective-clinical-outcome-measure-tool-for-hand-and-wrist-function-in-boxing
#14
Ian Gatt, Sophie Smith-Moore, Charlie Steggles, Mike Loosemore
BACKGROUND: The aim of this article was to explore retrospectively the Takei dynamometer as a valid and reliable outcome measure tool for hand and wrist pathology in the Great Britain amateur boxing squad between 2010 and 2014. METHODS: Longitudinal retrospective injury surveillance of the Great Britain boxing squad was performed from 2010 to 2014. The location, region affected, description, and duration of each injury were recorded by the team doctor and team physiotherapists...
May 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28486659/a-sequence-of-28%C3%A2-s-rrna-derived-small-rnas-is-enriched-in-mature-sperm-and-various-somatic-tissues-and-possibly-associates-with-inflammation
#15
Chen Chu, Lu Yu, Bin Wu, Li Ma, Lantao Gou, Miao He, Yunli Guo, Zhitong Li, Wei Gao, Shi Huijuan, Mofang Liu, Hongyan Wang, Charlie Degui Chen, Joël R Drevet, Yuchuan Zhou, Yonglian Zhang
No abstract text is available yet for this article.
May 9, 2017: Journal of Molecular Cell Biology
https://www.readbyqxmd.com/read/28478974/is-it-in-charlie-gard-s-best-interest-to-die
#16
Julian Savulescu
No abstract text is available yet for this article.
May 4, 2017: Lancet
https://www.readbyqxmd.com/read/28473611/operation-everest-ii-and-the-1978-habeler-messner-ascent-of-everest-without-bottled-o2-what-might-they-have-in-common
#17
Peter D Wagner
In 1978, Peter Habeler and Reinhold Messner climbed Everest without supplemental O2 Subsequently, Oelz and coworkers (9) assessed their cardiopulmonary function, finding no advantageous physiological attributes to explain their success, and leading West (18) to suggest that grit and determination were more important. In 1985, Charlie Houston, John Sutton and Al Cymerman hosted a scientific project assessing a simulated ascent of Everest (OE II) at the USARIEM. Included were measurements of O2 transport. In particular, mixed venous PO2 was measured at/near maximal exercise, for calculating pulmonary O2 diffusing capacity...
May 4, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28471670/sensitivity-of-photoelectron-angular-distributions-to-molecular-conformations-of-anions
#18
Cate S Anstöter, Charlie R Dean, Jan R R Verlet
An anion photoelectron imaging study probing the sensitivity of the photoelectron angular distribution (PAD) to conformational changes is presented. The PADs of a series of para-substituted phenolate anions is compared with those calculated using the Dyson orbital formalization. Good agreement was attained for the two observed direct detachment channels of all anions, except for the lowest-energy detachment channel of para-ethyl phenolate for which two conformations exist that yield very different PADs. The conformational freedom leads to an observed PAD that is the incoherent sum of the PADs from all conformers populated under experimental conditions...
May 8, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28465378/biliary-tract-and-liver-complications-in-polycystic-kidney-disease
#19
Parminder K Judge, Charlie H S Harper, Benjamin C Storey, Richard Haynes, Martin J Wilcock, Natalie Staplin, Raph Goldacre, Colin Baigent, Jane Collier, Michael Goldacre, Martin J Landray, Christopher G Winearls, William G Herrington
Polycystic liver disease is a well described manifestation of autosomal dominant polycystic kidney disease (ADPKD). Biliary tract complications are less well recognized. We report a 50-year single-center experience of 1007 patients, which raised a hypothesis that ADPKD is associated with biliary tract disease. We tested this hypothesis using all England Hospital Episode Statistics data (1998-2012), within which we identified 23,454 people with ADPKD and 6,412,754 hospital controls. Hospitalization rates for biliary tract disease, serious liver complications, and a range of other known ADPKD manifestations were adjusted for potential confounders...
May 2, 2017: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/28455191/electro-acupuncture-for-post-stroke-spasticity-a-systematic-review-and-meta-analysis
#20
REVIEW
Yiyi Cai, Claire Shuiqing Zhang, Shaonan Liu, Zehuai Wen, Anthony Lin Zhang, Xinfeng Guo, Chuanjian Lu, Charlie C Xue
OBJECTIVE: To evaluate the effects and safety of electro-acupuncture (EA) for stroke patients with spasticity. DATA SOURCES: Five English (PubMed, EMBASE, CINAHL, Cochrane Central Register of Controlled Trials and AMED) and four Chinese databases (CBM, CNKI, CQVIP and Wanfang) were searched from their inception to September 2016. DATA SELECTION: Randomized controlled trials were included if they measured spasticity with Modified Ashworth Scale in stroke patients and investigated the add-on effects of electro-acupuncture to routine pharmacotherapy and rehabilitation therapies...
April 25, 2017: Archives of Physical Medicine and Rehabilitation
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