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https://www.readbyqxmd.com/read/28429846/protected-engagement-time-on-older-adult-mental-health-wards-a-thematic-analysis-of-the-views-of-patients-carers-and-staff
#1
Emily Dodd, Richard Cheston, Charlie Procter, Sarah Heneker, Richard Gray, Chris Fox, Fiona Nolan
During protected engagement time (PET), ward routines are adjusted so that staff can spend time together with patients without interruption. The aim of PET is to increase staff and patient interaction on wards, and ultimately patient well-being. Although PET has been implemented on inpatient wards within the UK, including older adult wards, there is no systematic evidence as to how PET is carried out or how it is experienced by staff, patients, and families. Semistructured interviews were conducted with 28 participants (8 patients, 10 family members, and 10 ward staff) from three different wards with PET, and transcriptions were analysed using thematic analysis...
April 21, 2017: International Journal of Mental Health Nursing
https://www.readbyqxmd.com/read/28429782/electrochemical-generation-of-sulfur-vacancies-in-the-basal-plane-of-mos2-for-hydrogen-evolution
#2
Charlie Tsai, Hong Li, Sangwook Park, Joonsuk Park, Hyun Soo Han, Jens K Nørskov, Xiaolin Zheng, Frank Abild-Pedersen
Recently, sulfur (S)-vacancies created on the basal plane of 2H-molybdenum disulfide (MoS2) using argon plasma exposure exhibited higher intrinsic activity for the electrochemical hydrogen evolution reaction than the edge sites and metallic 1T-phase of MoS2 catalysts. However, a more industrially viable alternative to the argon plasma desulfurization process is needed. In this work, we introduce a scalable route towards generating S-vacancies on the MoS2 basal plane using electrochemical desulfurization. Even though sulfur atoms on the basal plane are known to be stable and inert, we find that they can be electrochemically reduced under accessible applied potentials...
April 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28428263/different-requirements-of-functional-telomeres-in-neural-stem-cells-and-terminally-differentiated-neurons
#3
Anastasia Lobanova, Robert She, Simon Pieraut, Charlie Clapp, Anton Maximov, Eros Lazzerini Denchi
Telomeres have been studied extensively in peripheral tissues, but their relevance in the nervous system remains poorly understood. Here, we examine the roles of telomeres at distinct stages of murine brain development by using lineage-specific genetic ablation of TRF2, an essential component of the shelterin complex that protects chromosome ends from the DNA damage response machinery. We found that functional telomeres are required for embryonic and adult neurogenesis, but their uncapping has surprisingly no detectable consequences on terminally differentiated neurons...
April 20, 2017: Genes & Development
https://www.readbyqxmd.com/read/28428185/investments-in-cancer-research-awarded-to-uk-institutions-and-the-global-burden-of-cancer-2000-2013-a-systematic-analysis
#4
Mahiben Maruthappu, Michael G Head, Charlie D Zhou, Barnabas J Gilbert, Majd A El-Harasis, Rosalind Raine, Joseph R Fitchett, Rifat Atun
OBJECTIVES: To systematically categorise cancer research investment awarded to United Kingdom (UK) institutions in the period 2000-2013 and to estimate research investment relative to disease burden as measured by mortality, disability-adjusted life years (DALYs) and years lived with disability (YLDs). DESIGN: Systematic analysis of all open-access data. SETTING AND PARTICIPANTS: Public and philanthropic funding to all UK cancer research institutions, 2000-2013...
April 20, 2017: BMJ Open
https://www.readbyqxmd.com/read/28424015/susceptibility-weighted-imaging-in-acute-cerebral-ischemia-review-of-emerging-technical-concepts-and-clinical-applications
#5
Charlie Chia-Tsong Hsu, Gigi Nga Chi Kwan, Sachintha Hapugoda, Michelle Craigie, Trevor William Watkins, E Mark Haacke
Susceptibility weighted imaging (SWI) is an essential magnetic resonance imaging sequence in the assessment of acute ischemic stroke. In this article, we discuss the physics principals and clinical application of conventional SWI and multi-echo SWI sequences. We review the research evidence and practical approach of SWI in acute ischemic stroke by focusing on the detection and characterization of thromboembolism in the cerebral circulation. In addition, we discuss the role of SWI in the assessment of neuroparenchyma by depiction of asymmetric hypointense cortical veins in the ischemic territory (surrogate tissue perfusion), detection of existing microbleeds before stroke treatment and monitoring for hemorrhagic transformation post-treatment...
April 2017: Neuroradiology Journal
https://www.readbyqxmd.com/read/28421941/nurses-need-support-too
#6
Rachel Webb
Like everyone, I feel for the family of Charlie Gard, the baby who the High Court ruled last week should be allowed to die.
April 19, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28421829/hydrocephalus-and-trigeminal-neuralgia-exploring-the-association-and-management-options
#7
Yuuki Charlie Barke Na, Shyam Vijay Pujara, Ahmad Abdelhai Moussa, Amy Charlotte Gerrish, Surajit Basu
We report the successful surgical management of three patients with trigeminal neuralgia and hydrocephalus. MRI revealed no neurovascular contact at the trigeminal root entry zone. Trigeminal neuralgic symptoms were controlled following alleviation of hydrocephalus. We hypothesize that trigeminal nerve traction, secondary to hydrocephalus, as the cause for their trigeminal neuralgia.
April 19, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28420201/a-transcriptomic-comparison-of-two-bambara-groundnut-landraces-under-dehydration-stress
#8
Faraz Khan, Hui Hui Chai, Ishan Ajmera, Charlie Hodgman, Sean Mayes, Chungui Lu
The ability to grow crops under low-water conditions is a significant advantage in relation to global food security. Bambara groundnut is an underutilised crop grown by subsistence farmers in Africa and is known to survive in regions of water deficit. This study focuses on the analysis of the transcriptomic changes in two bambara groundnut landraces in response to dehydration stress. A cross-species hybridisation approach based on the Soybean Affymetrix GeneChip array has been employed. The differential gene expression analysis of a water-limited treatment, however, showed that the two landraces responded with almost completely different sets of genes...
April 18, 2017: Genes
https://www.readbyqxmd.com/read/28414863/commentary-on-the-importance-of-looking-at-nonlinearity-and-developmental-effects-a-reflection-on-flom-et%C3%A2-al-2017
#9
Charlie Rioux, Sophie Parent, Jean R Séguin
By examining both linear and curvilinear associations between mental development and activity level, the study by Flom et al. (Journal of Child Psychology and Psychiatry, 2017) highlights the importance of going beyond linear associations in psychological fields of research. Results from Flom et al. (Journal of Child Psychology and Psychiatry, 2017) also raise interesting questions for future research. First, studies should look at variables that may explain the associations between activity level and mental development, such as self-regulation and attention...
May 2017: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/28409655/9-1-1-triage-of-non-traumatic-chest-pain-association-with-hospital-diagnosis
#10
Greg Scott, Jeff J Clawson, Isabel Gardett, Meghan Broadbent, Nathan Williams, Conrad Fivaz, Gigi Marshall, Tracey Barron, Christopher Olola
OBJECTIVE: Chest pain is one of the most common reasons people seek emergency care-and one of the most critical. In the United States, chest pain is the second most common reason for emergency department (ED) visits. A patient's primary complaint of "chest pain" may reflect a broad range of underlying causes; therefore, it is important that emergency medical service (EMS) agencies gain a thorough understanding of these cases, beginning with the initial management of chest pain in the 9-1-1 center...
April 14, 2017: Prehospital Emergency Care
https://www.readbyqxmd.com/read/28404954/upregulation-of-the-long-non-coding-rna-pvt1-promotes-esophageal-squamous-cell-carcinoma-progression-by-acting-as-a-molecular-sponge-of-mir-203-and-lasp1
#11
Pin-Dong Li, Jian-Li Hu, Charlie Ma, Hong Ma, Jing Yao, Li-Li Chen, Jing Chen, Tian-Tian Cheng, Kun-Yu Yang, Gang Wu, Wen-Jie Zhang, Ru-Bo Cao
Long non-coding RNAs are a group of non-coding RNAs longer than 200 nucleotides and possess diverse functions and exhibit exquisite cell-specific and developmental dynamic expression patterns. The role of the long non-coding RNA PVT1 in esophageal squamous cell carcinoma remains unsolved. Here, we showed that PVT1 expression is significantly up-regulated in ESCC tumor samples compared with their normal counterparts. Knockdown of PVT1 suppressed tumor growth in vitro and in vivo. Further studies revealed that silence of PVT1 lead to up-regulation of miR-203, and vice versa...
March 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28402685/extending-predict-first-to-the-design-make-test-cycle-in-small-molecule-drug-discovery
#12
Scott Harrison, Brian Lahue, Zhengwei Peng, Anthony Donofrio, Charlie Chang, Meir Glick
No abstract text is available yet for this article.
April 12, 2017: Future Medicinal Chemistry
https://www.readbyqxmd.com/read/28402086/the-effect-of-increased-microporosity-on-bone-formation-within-silicate-substituted-scaffolds-in-an-ovine-posterolateral-spinal-fusion-model
#13
Melanie Jean Coathup, Gordon William Blunn, Charlie Campion, Chih-Yuan Ho, Karin Angela Hing
This study compared the bone forming capacity of the same formulation of silicate-substituted bone graft substitute materials with different microporosity in an instrumented posterolateral spinal fusion ovine model. Materials with a strut porosity of (i) 22.5% (SiCaP) or (ii) 36.0% (SiCaP(+)) were packed along either side of the spine. Bone apposition rates, % new bone formation, % bone-implant contact, and % graft resorption were quantified at 8, 12, and 24 weeks post surgery. Computed Tomography (CT) was used to grade the formation of fusion bridges between vertebrae...
May 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28401949/inverting-polar-domains-via-electrical-pulsing-in-metallic-germanium-telluride
#14
Pavan Nukala, Mingliang Ren, Rahul Agarwal, Jacob Berger, Gerui Liu, A T Charlie Johnson, Ritesh Agarwal
Germanium telluride (GeTe) is both polar and metallic, an unusual combination of properties in any material system. The large concentration of free-carriers in GeTe precludes the coupling of external electric field with internal polarization, rendering it ineffective for conventional ferroelectric applications and polarization switching. Here we investigate alternate ways of coupling the polar domains in GeTe to external electrical stimuli through optical second harmonic generation polarimetry and in situ TEM electrical testing on single-crystalline GeTe nanowires...
April 12, 2017: Nature Communications
https://www.readbyqxmd.com/read/28399988/youth-social-behaviour-and-network-therapy-y-sbnt-adaptation-of-a-family-and-social-network-intervention-for-young-people-who-misuse-alcohol-and-drugs-a-randomised-controlled-feasibility-trial
#15
Judith Watson, Paul Toner, Ed Day, Donna Back, Louca-Mai Brady, Caroline Fairhurst, Charlotte Renwick, Lorna Templeton, Shabana Akhtar, Charlie Lloyd, Jinshuo Li, Kim Cocks, Sangeeta Ambegaokar, Steve Parrott, Paul McArdle, Eilish Gilvarry, Alex Copello
BACKGROUND: Family interventions appear to be effective at treating young people's substance misuse. However, implementation of family approaches in UK services is low. This study aimed to demonstrate the feasibility of recruiting young people to an intervention based on an adaptation of adult social behaviour and network therapy. It also sought to involve young people with experience of using substance misuse services in the research process. OBJECTIVES: To demonstrate the feasibility of recruiting young people to family and social network therapy and to explore ways in which young people with experience of using substance misuse services could be involved in a study of this nature...
March 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28385723/fabp4-cre-mediated-sirt6-deletion-impairs-adipose-tissue-function-and-metabolic-homeostasis-in-mice
#16
Xiwen Xiong, Cuicui Zhang, Yang Zhang, Rui Fan, Xinlai Qian, Xiaocheng Charlie Dong
SIRT6 is a member of sirtuin family of deacetylases involved in diverse processes including genome stability, metabolic homeostasis, and anti-inflammation. However, its function in the adipose tissue is not well understood. To examine the metabolic function of SIRT6 in the adipose tissue, we generated two mouse models that are deficient in Sirt6 using the Cre-lox approach. Two commonly used Cre lines that are driven by either the mouse Fabp4 or Adipoq gene promoter were chosen for this study. The Sirt6 knockout mice generated by the Fabp4-Cre line (Sirt6f/f:Fabp4-Cre) had a significant increase in both body weight and fat mass, and exhibited glucose intolerance and insulin resistance as compared with the control wildtype mice...
April 6, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28375892/metal-artifact-reduction-sequence-mri-abnormalities-in-asymptomatic-patients-with-a-ceramic-on-polyethylene-total-hip-replacement
#17
Jason M Jennings, J Ryan Martin, Raymond H Kim, Charlie C Yang, Todd M Miner, Douglas A Dennis
BACKGROUND: Magnetic resonance imaging (MRI) is a commonly utilized screening modality in patients with a metal-on-metal (MoM) total hip replacement. The prevalence of clinically important fluid collections may be overestimated since these collections have been reported to occur in asymptomatic patients with MoM and other bearing surfaces. The purpose of this study was to determine the frequency and types of MRI-documented adverse local tissue reactions in asymptomatic patients with a ceramic-on-polyethylene (CoP) total hip replacement...
April 5, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28375754/applying-behavioral-conditioning-to-identify-anticipatory-behaviors
#18
Bethany L Krebs, Erika Torres, Charlie Chesney, Veronica Kantoniemi Moon, Jason V Watters
The ability to predict regular events can be adaptive for nonhuman animals living in an otherwise unpredictable environment. Animals may exhibit behavioral changes preceding a predictable event; such changes reflect anticipatory behavior. Anticipatory behavior is broadly defined as a goal-directed increase in activity preceding a predictable event and can be useful for assessing well being in animals in captivity. Anticipation may look different in different animals, however, necessitating methods to generate and study anticipatory behaviors across species...
April 2017: Journal of Applied Animal Welfare Science: JAAWS
https://www.readbyqxmd.com/read/28370488/asymmetric-sequential-cu-catalyzed-1-6-1-4-conjugate-additions-of-hard-nucleophiles-to-cyclic-dienones-determination-of-absolute-configurations-and-origins-of-enantioselectivity
#19
Marc Mauduit, Charlie Blons, Marie S T Morin, Thibault E Schmid, Thomas Vives, Sophie Colombel-Rouen, Olivier Baslé, Thibault Reynaldo, Cody L Covington, Stephanie Halbert, Sean N Cuskelly, Paul V Bernhardt, Craig M Williams, Jeanne Crassous, Prasad L Polavarapu, Christophe Crévisy, Hélène Gérard
The first stereo-controlled Cu-catalyzed sequential 1,6/1,4-asymmetric conjugate addition (ACA) of C-metalated hard nucleophiles to cyclic dienones is reported. The use of DiPPAM, followed by a phosphoramidite, as the stereoinducing ligands facilitated both high ee's for the 1,6-ACA and high de's for the 1,4-ACA reaction components, thus affording enantio-enriched 1,3-dialkylated moieties. The absolute configurations were determined using vibrational circular dichroism (VCD) and optical rotatory dispersion (ORD) spectroscopy, in combination with DFT calculations and X-Ray analysis...
April 3, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28365084/perianal-synovial-sarcoma-treated-postoperatively-with-iodine-125-brachytherapy-technical-details
#20
Susan Tovey, Clare Stannard, Gerrie Maree, Robin Hiscock, Charlie Thomson, Eugenio Panieri, Paul Goldberg
PURPOSE: A 23-year-old lady had an incompletely excised perianal sarcoma. Brachytherapy as the sole treatment, rather than further surgery or external beam radiotherapy, was considered to be the best option with the least morbidity. METHODS AND MATERIALS: Although brachytherapy techniques with iridium-192 for anal and rectal carcinoma are well described using a perianal template, the size of the template was not suitable for a two-plane implant that needed to be in situ for about 4 days...
March 29, 2017: Brachytherapy
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