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https://www.readbyqxmd.com/read/28098862/rhein-suppresses-matrix-metalloproteinase-production-by-regulating-the-rac1-ros-mapk-ap-1-pathway-in-human-ovarian-carcinoma-cells
#1
Guomei Zhou, Fenghui Peng, Yanping Zhong, Yanhua Chen, Min Tang, Danrong Li
Matrix metalloproteinases (MMPs) are a family of calcium-dependent zinc-containing endopeptidases, which play an integral role in migration and invasion of ovarian cancer. Rac1 proteins might mostly influence cell migration and invasion by generating endogenous reactive oxygen species. Therefore, inhibiting MMPs and regulating the Rac1/ROS/MAPK/AP-1 pathway may be a new therapeutic strategy for ovarian cancer. In this study, we found that rhein could suppress the invasion and migration of SKOV3-PM4 cells with characteristics of directional highly lymphatic metastasis...
January 17, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28098837/casein-glycomacropeptide-hydrolysates-exert-cytoprotective-effect-against-cellular-oxidative-stress-by-up-regulating-ho-1-expression-in-hepg2-cells
#2
Tiange Li, Bin Chen, Min Du, Jiajia Song, Xue Cheng, Xu Wang, Xueying Mao
Oxidative stress is considered as an important mediator in the progression of metabolic disorders. The objective of this study was to investigate the potential hepatoprotective effects and mechanisms of bovine casein glycomacropeptide hydrolysates (GHP) on hydrogen peroxide (H₂O₂)-induced oxidative damage in HepG2 cells. Results showed that GHP significantly blocked H₂O₂-induced intracellular reactive oxygen species (ROS) generation and cell viability reduction in a dose-dependent manner. Further, GHP concentration-dependently induced heme oxygenase-1 (HO-1) expression and increased nuclear factor-erythroid 2-related factor 2 (Nrf2) nuclear translocation...
January 15, 2017: Nutrients
https://www.readbyqxmd.com/read/28098836/association-of-school-environment-and-after-school-physical-activity-with-health-related-physical-fitness-among-junior-high-school-students-in-taiwan
#3
Kai-Yang Lo, Min-Chen Wu, Shu-Chin Tung, City C Hsieh, Hsueh-Hua Yao, Chien-Chang Ho
The relationship between students' school environment and exercise habits is complex, and is affected by numerous factors. However, the few studies that have been conducted on this relationship have reported inconsistent results, especially regarding Taiwanese students. We conducted this cross-sectional study to investigate the association of school environment and after-school physical activity with health-related physical fitness in Taiwanese adolescents. Data were drawn from a national survey conducted by the Ministry of Education in Taiwan in 2008 of health-related physical fitness measurements among junior high school students (649,442 total) in grades seven to nine...
January 15, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28098803/optimization-of-the-production-of-1-phenylethanol-using-enzymes-from-flowers-of-tea-camellia-sinensis-plants
#4
Fang Dong, Ying Zhou, Lanting Zeng, Naoharu Watanabe, Xinguo Su, Ziyin Yang
1-Phenylethanol (1PE) can be used as a fragrance in food flavoring and cosmetic industries and as an intermediate in the pharmaceutical industry. 1PE can be synthesized from acetophenone, and the cost of 1PE is higher than the cost of acetophenone. Therefore, it is important to establish an effective and low-cost approach for producing 1PE. Our previous studies found that tea (Camellia sinensis) flowers, which are an abundant and waste resource, contained enzymes that could transform acetophenone to 1PE. In the present study, we extracted crude enzymes from tea flowers and optimized the production conditions of 1PE using response surface methodology...
January 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28098791/development-of-high-throughput-method-for-measurement-of-vascular-nitric-oxide-generation-in-microplate-reader
#5
Soad S Abd El-Hay, Christa L Colyer
BACKGROUND: Despite the importance of nitric oxide (NO) in vascular physiology and pathology, a high-throughput method for the quantification of its vascular generation is lacking. OBJECTIVE: By using the fluorescent probe 4-amino-5-methylamino-2',7'-difluorofluorescein (DAF-FM), we have optimized a simple method for the determination of the generation of endothelial nitric oxide in a microplate format. METHODS: A nitric oxide donor was used (3-morpholinosydnonimine hydrochloride, SIN-1)...
January 13, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28098788/evaluation-of-potential-average-daily-doses-adds-of-pm2-5-for-homemakers-conducting-pan-frying-inside-ordinary-homes-under-four-ventilation-conditions
#6
Seonyeop Lee, Sol Yu, Sungroul Kim
Several studies reported that commercial barbecue restaurants likely contribute to the indoor emission of particulate matters with a diameter of 2.5 micrometers or less (PM2.5) while pan-frying meat. However, there is inadequate knowledge of exposure level to indoor PM2.5 in homes and the contribution of a typical indoor pan-frying event. We measured the indoor PM2.5 concentration and, using Monte-Carlo simulation, estimated potential average daily dose (ADD) of PM2.5 for homemakers pan-frying a piece of pork inside ordinary homes...
January 13, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28098777/new-irradiation-method-with-indocyanine-green-loaded-nanospheres-for-inactivating-periodontal-pathogens
#7
Yasuyuki Sasaki, Jun-Ichiro Hayashi, Takeki Fujimura, Yuki Iwamura, Genta Yamamoto, Eisaku Nishida, Tasuku Ohno, Kosuke Okada, Hiromitsu Yamamoto, Takeshi Kikuchi, Akio Mitani, Mitsuo Fukuda
Antimicrobial photodynamic therapy (aPDT) has been proposed as an adjunctive strategy for periodontitis treatments. However, use of aPDT for periodontal treatment is complicated by the difficulty in accessing morphologically complex lesions such as furcation involvement, which the irradiation beam (which is targeted parallel to the tooth axis into the periodontal pocket) cannot access directly. The aim of this study was to validate a modified aPDT method that photosensitizes indocyanine green-loaded nanospheres through the gingivae from outside the pocket using a diode laser...
January 13, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28098742/does-transection-of-the-c2-nerve-roots-during-c1-lateral-mass-screw-placement-for-atlantoaxial-fixation-result-in-a-superior-outcome-a-systematic-review-of-the-literature-and-meta-analysis
#8
Jetan H Badhiwala, Farshad Nassiri, Christopher D Witiw, Alireza Mansouri, Saleh A Almenawer, Michael G Fehlings
STUDY DESIGN: Systematic review and meta-analysis. OBJECTIVE: To evaluate the clinical and functional outcomes of transection of the C2 roots during C1 lateral mass screw placement for atlantoaxial fixation. SUMMARY OF BACKGROUND DATA: Transection of the C2 nerve roots has been recommended during atlantoaxial fixation to facilitate C1 lateral mass screw placement and possibly reduce post-operative occipital neuralgia, although this practice remains controversial...
January 16, 2017: Spine
https://www.readbyqxmd.com/read/28098740/adult-scoliosis-deformity-surgery-comparison-of-outcomes-between-1-vs-2-attending-surgeons
#9
Jaime A Gomez, Virginie Lafage, Daniel M Scuibba, Shay Bess, Gregory M Mundis, Barthelemy Liabaud, Regina Hanstein, Christopher Shaffrey, Michael Kelly, Christopher Ames, Justin S Smith, Peter G Passias, Thomas Errico, Frank Schwab
STUDY DESIGN: Retrospective review of prospectively collected data. OBJECTIVE: Assess outcomes of adult spinal deformity (ASD) surgery performed by 1 vs. 2 attending surgeons. SUMMARY OF BACKGROUND DATA: ASD centers have developed 2-attending teams in order to improve efficiency; their effects on complications and outcomes have not been reported. METHODS: ASD patients with ≥5 levels fused and > 2-year follow-up were included...
January 16, 2017: Spine
https://www.readbyqxmd.com/read/28098734/multimodal-fundus-imaging-of-outer-retinal-tubulations-in-choroidal-osteoma-patients
#10
Yi Xuan, Yongjin Zhang, Min Wang, Jinli Guo, Lei Li, Wei Liu, Xiaofeng Ye
PURPOSE: To evaluate the morphological findings of outer retinal tubulations (ORTs) shown on multimodal imaging modalities in patients with choroidal osteoma. METHODS: Nineteen eyes of 17 patients with choroidal osteoma underwent full clinical and imaging assessments. Color fundus photography, spectral-domain optical coherence tomography (OCT), and en face OCT were used to identify and detect the characteristics of ORT structures, including the shape, configuration, location, and distribution in the fundus...
January 16, 2017: Retina
https://www.readbyqxmd.com/read/28098732/significant-reduction-of-peripapillary-choroidal-thickness-in-patients-with-unilateral-branch-retinal-vein-occlusion
#11
Hae Min Kang, Jeong Hoon Choi, Hyoung Jun Koh, Christopher Seungkyu Lee, Sung Chul Lee
PURPOSE: To evaluate changes in peripapillary choroidal thickness in patients with branch retinal vein occlusion (BRVO) over 12 months, using spectral-domain optical coherence tomography with enhanced depth imaging. METHODS: This retrospective, interventional case series included 20 treatment-naive patients with unilateral BRVO with at least 12 months follow-up. The peripapillary choroidal thickness was measured over 12 months. RESULTS: In BRVO-affected eyes, the mean peripapillary choroidal thickness was 213...
January 16, 2017: Retina
https://www.readbyqxmd.com/read/28098557/length-dependent-flagellar-growth-of-vibrio-alginolyticus-revealed-by-real-time-fluorescent-imaging
#12
Meiting Chen, Ziyi Zhao, Jin Yang, Kai Peng, Matthew A B Baker, Fan Bai, Chien-Jung Lo
Bacterial flagella are extracellular filaments that drive swimming in bacteria. During its assembly, flagellins are transported unfolded through the central channel in the flagellum to the growing tip. Here we applied in vivo fluorescent imaging to monitor in real time the Vibrio alginolyticus polar flagella growth. The flagellar growth rate is found to be highly length-dependent. Initially, the flagellum grows at a constant rate (50nm/min) when shorter than 1500nm. The growth rate decays sharply when the flagellum grows longer...
January 18, 2017: ELife
https://www.readbyqxmd.com/read/28098507/development-and-evaluation-of-a-loop-mediated-isothermal-amplification-lamp-assay-for-the-detection-of-haemonchus-contortus-in-goat-fecal-samples
#13
Xin Yang, Mingwei Qi, Zongze Zhang, Chong Gao, Chunqun Wang, Weiqiang Lei, Li Tan, Junlong Zhao, Rui Fang, Min Hu
Haemonchus contortus is one of the most significant strongylid nematodes infecting small ruminants and causes great economic losses to the livestock industry worldwide. Accurate diagnosis of H. contortus is crucial to control the infection. Traditional microscopic examinations are the most common methods for the diagnosis of H. contortus, but they are time-consuming and inaccurate. Molecular methods based on PCR are more accurate, but need expensive machines usually only used in the laboratory. Loop-mediated isothermal amplification (LAMP) is a rapid, simple, specific and sensitive method that has been widely used to detect viruses, bacteria and parasites...
January 18, 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/28098497/magnetic-resonance-arthrography-results-that-indicate-surgical-treatment-for-partial-articular-sided-supraspinatus-tendon-avulsion-a-retrospective-study-in-a-tertiary-center
#14
Seok Hahn, Young Han Lee, Yong-Min Chun, Eun Hae Park, Jin-Suck Suh
Background Specific findings on magnetic resonance arthrography (MRA) that indicate the need for surgery in patients with partial articular-sided supraspinatus tendon avulsion (PASTA) are not well understood. Purpose To determine which MRA findings are characteristic of patients who undergo surgery for PASTA. Material and Methods From July 2011 to February 2014, MRA findings for patients treated for PASTA were retrospectively reviewed. The patients were divided into two groups: conservative treatment and surgical repair...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28098448/new-insights-into-trihalomethane-and-haloacetic-acid-formation-potentials-correlation-with-the-molecular-composition-of-natural-organic-matter-in-source-water
#15
Xin Wang, Haifeng Zhang, Yahe Zhang, Quan Shi, Juan Wang, Jianwei Yu, Min Yang
Natural organic matter (NOM) represents the major source of precursors for disinfection byproducts (DBPs), such as trihalomethanes (THMs) and haloacetic acids (HAAs), formed during disinfection of drinking water, but the molecular composition and reactivity of NOM remain not well understood. In this study, electrospray ionization coupled to Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) was used to characterize the molecular composition of NOM of twenty source waters taken across China for the purpose of determining the major precursors of THMs and HAAs at molecular level...
January 18, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28098395/first-uhplc-ms-ms-method-coupled-with-automated-on-line-spe-for-quantification-both-of-tacrolimus-and-everolimus-in-peripheral-blood-mononuclear-cells-and-its-application-on-samples-from-co-treated-pediatric-patients
#16
Debora Pensi, Amedeo De Nicolò, Michele Pinon, Clarissa Pisciotta, Pier Luigi Calvo, Antonello Nonnato, Renato Romagnoli, Francesco Tandoi, Giovanni Di Perri, Antonio D'Avolio
Tacrolimus (TAC, FK-506) and everolimus (EVE, RAD001) are immunosuppressors used to treat pediatric patients undergoing liver transplantation. Their hematic TDM by liquid chromatography became standard practice. However, it does not always reflect concentrations at their active site. Our aim was to develop and validate a new method for the simultaneous TAC and EVE quantification into target cells: Peripheral-Blood-Mononuclear-Cells (PBMCs). PBMCs were collected using Cell-Preparation-Tubes; cells number and MCV were evaluated by an automatic cell counter...
January 18, 2017: Journal of Mass Spectrometry: JMS
https://www.readbyqxmd.com/read/28098357/partial-purification-characterization-and-thermal-inactivation-kinetics-of-peroxidase-and-polyphenol-oxidase-isolated-from-kalipatti-sapota-manilkara-zapota
#17
Vishwasrao Chandrahas, Chakraborty Snehasis, Ananthanarayan Laxmi
BACKGROUND: The extraction, purification, and characterization of peroxidase (POD) and polyphenol oxidase (PPO) were studied for Kalipatti sapota fruit. The crude enzyme extract was partially purified by ammonium sulfate precipitation followed by BioGel P100 size exclusion and Unosphere Q anion-exchange chromatography. RESULTS: Molecular weights of 20 kDa (POD) and 24 kDa (PPO) were indicated by SDS-PAGE. A single band was observed on SDS-PAGE with a fold purity of 10...
January 18, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/28098309/multi-shelled-ceria-hollow-spheres-with-a-tunable-shell-number-and-thickness-and-their-superior-catalytic-activity
#18
Yuanyuan Liao, Yuan Li, Lei Wang, Yongxia Zhao, Danyang Ma, Biqing Wang, Yongxia Wan, Shengliang Zhong
In this work, ceria multi-shelled nanospheres with a tunable shell number and thickness were prepared by a facile coordination polymer (CP) precursor method without the use of any template and surfactant. Interestingly, the number, thickness and structure of the shell can be tuned by varying the reaction time, reaction temperature, ratio of reagent and calcination temperature. The formation process of the multi-shelled hollow spheres was also investigated, which experienced a core contraction and shell separation process...
January 18, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28098295/spontaneous-decoration-of-silicon-surfaces-with-moox-nanoparticles-for-the-sunlight-assisted-hydrogen-evolution-reaction
#19
T-G Truong, C Mériadec, B Fabre, J-F Bergamini, O de Sagazan, S Ababou-Girard, G Loget
The immersion of oxide-free Si surfaces in MoS4(2-) aqueous solutions induces their spontaneous decoration with isolated MoOx nanoparticles (NPs). The process is versatile and was used on planar Si (100) as well as on antireflective Si (111) micro-pyramid (SimPy) arrays. The NP decoration does not affect the optical properties of the surface in the visible range and improves the performance of the hydrogen evolution reaction (HER) under simulated sunlight. The simplicity and the scalability of the technique make it highly promising for the fabrication of catalytically active photoelectrodes...
January 18, 2017: Nanoscale
https://www.readbyqxmd.com/read/28098291/investigation-into-the-bioavailability-of-milk-protein-derived-peptides-with-dipeptidyl-peptidase-iv-inhibitory-activity-using-caco-2-cell-monolayers
#20
Isabelle M E Lacroix, Xiu-Min Chen, David D Kitts, Eunice C Y Li-Chan
In recent years, peptides derived from a variety of dietary proteins have been reported to exhibit inhibitory activity against the dipeptidyl-peptidase IV (DPP-IV) enzyme, a target in the management of type 2 diabetes. While much attention has been given to the production and identification of peptides with DPP-IV inhibitory activity from food proteins, particularly dairy proteins, little is known on the bioavailability of these molecules. In this study, the stability and transport of five previously identified milk-derived peptides (LKPTPEGDL, LPYPY, IPIQY, IPI and WR) and a whey protein isolate (WPI) digest with DPP-IV-inhibitory activity were investigated using Caco-2 cell monolayers as a model system for human intestinal absorption...
January 18, 2017: Food & Function
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