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https://www.readbyqxmd.com/read/29929201/sonidegib-a-novel-inhibitor-of-suicidal-erythrocyte-death
#1
Abdulla Al Mamun Bhuyan, Itishri Sahu, Hang Cao, Florian Lang
BACKGROUND/AIMS: The Hedgehog pathway disrupting drug sonidegib is used in the treatment of basal cell carcinoma. Side effects of sonidegib include anemia, which could result either from impaired erythropoiesis or from loss of erythrocytes e.g. due to suicidal erythrocyte death or eryptosis, which is characterized by cell membrane scrambling with phosphatidylserine translocation to the cell surface and by cell shrinkage. Eryptosis is stimulated by cell stress, including energy depletion, hyperosmotic shock, oxidative stress and excessive increase of cytosolic Ca2+ activity ([Ca2+]i)...
June 19, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29929196/cpg-odn-a-tlr9-agonist-aggravates-myocardial-ischemia-reperfusion-injury-by-activation-of-tlr9-p38-mapk-signaling
#2
Liang Xie, Songqing He, Na Kong, Ying Zhu, Yi Tang, Jianhua Li, Zhengbing Liu, Jing Liu, Jianbin Gong
BACKGROUND/AIMS: Toll-like receptors (TLRs) have been implicated in myocardial ischemia/ reperfusion (I/R) injury. We examined the effect of CpG-oligodeoxynucleotide (ODN) on myocardial I/R injury. METHODS: Male Sprague-Dawley rats were treated with either CpG-ODN or control ODN 1 h prior to myocardial ischemia (30 min) followed by reperfusion. Rats treated with phosphate-buffered saline (PBS) served as I/R controls (n = 8/group). Infarct size was determined by 2,3,5-triphenyltetrazolium chloride and Evans blue straining...
June 19, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29929193/induction-of-pro-inflammatory-response-via-activated-macrophage-mediated-nf-%C3%AE%C2%BAb-and-stat3-pathways-in-gastric-cancer-cells
#3
Yujuan Zhou, Longzheng Xia, Qiang Liu, Heran Wang, Jingguan Lin, Linda Oyang, Xiaoyan Chen, Xia Luo, Shiming Tan, Yutong Tian, Min Su, Ying Wang, Pan Chen, Yang Wu, Hui Wang, Qianjin Liao
BACKGROUND/AIMS: Chronic inflammation plays an important role in the initiation and progression of gastric cancer (GC). However, the role and relationship of activated macrophages with gastric mucous epithelium cells in initiating and maintaining the inflammatory process during gastric carcinogenesis remains unclear. METHODS: The tumour associated macrophages (TAMs) density of gastric cancer was characterized by immunohistochemistry, and the relationship between macrophages and gastric epithelium cells was analysed using an in vitro culture system that imitates the inflammatory microenvironment...
June 19, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29929175/kyphoplasty-with-purified-silicone-vk100-elastoplasty-to-treat-spinal-lytic-lesions-in-cancer-patients-a-retrospective-evaluation-of-41-cases
#4
Stefano Telera, Alfredo Pompili, Francesco Crispo, Maddalena Giovannetti, Andrea Pace, Veronica Villani, Alessandra Fabi, Isabella Sperduti, Laura Raus
OBJECTIVES: Balloon Kyphoplasty (BKP) for vertebral compression fractures (VCFs) in cancer patients is more challenging than for osteoporotic ones. Cord compressions are frequent and the incidence of complications ten-fold greater. Polymethylmetacrylate (PMMA) is the gold standard material for BKP but has disadvantages: exothermic reaction, short working time, rapid solidification, absence of osteoconduction. VK100 is a mixture of Dimethyl Methylvinyl siloxane and Barium Sulphate. It is elastic, adhesive to bone, leaves 30 min before solidification without exothermic reaction, and shows a stiffness close to the intact vertebrae...
June 15, 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29929137/mechanism-of-the-effect-of-ph-and-biochar-on-the-phytotoxicity-of-the-weak-acid-herbicides-imazethapyr-and-2-4-d-in-soil-to-rice-oryza-sativa-and-estimation-by-chemical-methods
#5
Kailin Liu, Ying He, Shiji Xu, Lifeng Hu, Kun Luo, Xiangying Liu, Min Liu, Xiaomao Zhou, Lianyang Bai
The existing form of an ionizable organic compound can simultaneously affect its soil adsorption and plant bioactivity. In this experiment, the adsorption and bioactivity of two weak acid herbicides (WAHs), imazethapyr and 2,4-D, were studied to explore the predominant mechanism by which the soil pH and the addition of biochar can influence the phytotoxicity of WAHs in soil. Then, the WAH concentration extracted by hollow fiber-based liquid-phase microextraction (CHF-LPME ), the in situ pore water concentration (CIPW ) and the added concentration (CAC ) were employed to estimate the phytotoxicity...
June 18, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29929131/high-potential-accumulation-and-tolerance-in-the-submerged-hydrophyte-hydrilla-verticillata-l-f-royle-for-nickel-contaminated-water
#6
Yang Song, Ling-Lei Zhang, Jia Li, Xiao-Jia He, Min Chen, Yun Deng
Water contamination by nickel (Ni) has become an increasing concern in recent decades. Hydrilla verticillata (L.f.) Royle has been recognized as a promising accumulator of several potentially toxic elements (PTEs) in phytoremediation, but its Ni-accumulation characteristics and its mechanisms of tolerance to Ni remain largely unknown. This research investigated the biochemical responses of leaves and stems of H. verticillata to various concentrations of Ni (5, 10, 15, 20, and 40 μM) over periods of 7, 14, or 21 days...
June 18, 2018: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29929124/electrochemical-oxidation-of-4-chlorophenol-for-wastewater-treatment-using-highly-active-uv-treated-tio-2-nanotubes
#7
Min Tian, Sapanbir S Thind, Jesse S Dondapati, Xinyong Li, Aicheng Chen
In the present work, we report on a facile UV treatment approach for enhancing the electrocatalytic activity of TiO2 nanotubes. The TiO2 nanotubes were prepared using an anodization oxidation method by applying a voltage of 40 V for 8 h in a DMSO + 2% HF solution, and further treated under UV light irradiation. Compared with Pt and untreated TiO2 nanotubes, the UV treated electrode exhibited a superior electrocatalytic activity toward the oxidation of 4-chlorophenol (4-ClPh). The effects of current density and temperature on the electrochemical oxidation of the 4-ClPh were also systematically investigated...
June 7, 2018: Chemosphere
https://www.readbyqxmd.com/read/29929114/one-pot-synthesis-and-biodistribution-of-fluorine-18-labeled-serum-albumin-for-vascular-imaging
#8
Falguni Basuli, Xiang Zhang, Mark R Williams, Jurgen Seidel, Michael V Green, Peter L Choyke, Rolf E Swenson, Elaine M Jagoda
INTRODUCTION: Equilibrium single-photon radionuclide imaging methods for assessing cardiac function and the integrity of the vascular system have long been in use for both clinical and research purposes. However, positron-emitting blood pool agents that could provide PET equivalents to these (and other) clinical procedures have not yet been adopted despite technical imaging advantages offered by PET. Our goal was to develop a PET blood pool tracer that not only meets necessary in vivo biological requirements but can be produced with an uncomplicated and rapid synthesis method which would facilitate clinical translation...
May 30, 2018: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/29929106/acetyl-assisted-autohydrolysis-of-sugarcane-bagasse-for-the-production-of-xylo-oligosaccharides-without-additional-chemicals
#9
Weiwei Zhang, Yanzhi You, Fuhou Lei, Pengfei Li, Jianxin Jiang
The aim of this work was to study acetyl-assisted autohydrolysis of sugarcane bagasse for the production of xylo-oligosaccharides without additional chemicals. A xylo-oligosaccharide yield of 50.35% was obtained in 10 min through sugarcane bagasse autohydrolysis at 200 °C; this yield was 49.64% after acetyl-assisted autohydrolysis of a 65:35 mixture of sugarcane bagasse/white birch at 160 °C for 100 min. The yield of xylo-oligosaccharides was close to that obtained at 180 °C/40 min and 200 °C/10 min through the autohydrolysis of sugarcane bagasse...
June 14, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29929080/28-noroleanane-derived-spirocyclic-triterpenoids-and-iridoid-glucosides-from-the-roots-of-phlomoides-umbrosa-turcz-kamelin-makhm-with-their-cytotoxic-effects
#10
Duc Dat Le, Duc Hung Nguyen, Bing Tian Zhao, Jeong Ah Kim, Seok Kyu Kim, Byung Sun Min, Jae Sue Choi, Mi Hee Woo
Four undescribed 23,24-O-isopropylidene-19(18 → 17)-abeo-28-noroleanane-derived spirocyclic triterpenoids and an undescribed 28-noroleanane-derived spirocyclic triterpenoid, together with five known 28-noroleanane-derived spirocyclic triterpenoids, were isolated and identified. In addition, three undescribed iridoid glucosides and four known ones were also identified. All the isolates were identified using spectroscopic techniques, and the absolute configurations of 28-noroleanane-derived spirocyclic triterpenoids were determined by CD method for the first time...
June 18, 2018: Phytochemistry
https://www.readbyqxmd.com/read/29929069/a-novel-electron-microscopic-method-for-measurement-of-mineral-content-in-enamel-lesions
#11
C Fowler, R J M Lynch, D Shingler, D Walsh, C Carson, A Neale, R J Willson, A Brown
OBJECTIVE: To assess Scanning Electron Microscopy in Back-Scattered Emission mode (BSE-SEM) for measurement of lesion mineral content as a function of depth. Direct comparison is made with Transverse Micro-Radiography (TMR) and Surface Micro-Hardness (SMH) on carious and erosive lesions. DESIGN: Caries lesions prepared from sound bovine enamel at 37 °C and pH 4.6 in unsaturated (7d) or part-saturated (8d, 4.1 mM Ca2+ , 8 mM Pi) lactic acid /methyl cellulose gel system, followed by TMR analysis...
June 13, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29929060/perfusion-pressure-of-a-new-cannulating-fenestrated-pedicle-screw-during-cement-augmentation
#12
Zhirong Wang, Wen Zhang, Hao Xu, Aiqing Lu, Huilin Yang, Zong-Ping Luo
BACKGROUND: Cannulating fenestrated pedicle screws are effective for fixating osteoporotic vertebrae. However, a major limitation is the excessive pressure required to inject a sufficient amount of cement into the vertebral body through the narrow hole of a pedicle screw. We have recently proposed a new cannulating fenestrated pedicle screw with a large hole diameter and a matched inner pin for screw-strength maintenance. Our purpose was to determine whether the new screw can significantly reduce bone-cement perfusion pressure during cement augmentation, METHODS: Two different methods were used to examine perfusion pressure...
June 18, 2018: Clinical Biomechanics
https://www.readbyqxmd.com/read/29929056/n-acetyl-cysteine-inhibits-lipopolysaccharide-mediated-induction-of-interleukin-6-synthesis-in-mc3t3-e1-cells-through-the-nf-kb-signaling-pathway
#13
Ling Guo, Hui Zhang, Wangyang Li, Danting Zhan, Min Wang
BACKGROUND: Interleukin-6 (IL-6) is a potent stimulator of osteoclastic activity. Lipopolysaccharide (LPS) has been shown to regulate the expression of potent inflammatory factors, including TNF-α and IL-6. Currently, effective therapeutic treatments for bacteria-caused bone destruction are limited. N-acetyl cysteine (NAC) is an antioxidant small molecule that possibly modulates osteoblastic differentiation. However, whether NAC can affect the LPS-mediated reduction of IL-6 synthesis in MC3T3-E1 cells is still unknown...
June 6, 2018: Archives of Oral Biology
https://www.readbyqxmd.com/read/29929010/detection-of-fetal-subchromosomal-aberration-with-cell-free-dna-screening-led-to-diagnosis-of-parental-translocation-review-of-11344-consecutive-cases-in-a-university-hospital
#14
Ye-Qing Qian, Xiao-Qing Wang, Min Chen, Yu-Qin Luo, Kai Yan, Yan-Mei Yang, Bei Liu, Li-Ya Wang, Ying-Zhi Huang, Hong-Ge Li, Hang-Yi Pan, Fan Jin, Min-Yue Dong
BACKGROUND: Fetal chromosome aberrations and sub-chromosomal copy number variations (CNVs) are not rare. There are several ways to detect duplications and deletions; cell-free DNA screening (cfDNA screening) is nowadays an accurate and safe detection method. The objective of this study is to report the feasibility of cfDNA screening as an indicator of parental balanced chromosome translocation. RESULTS: From February 2015 to March 2016, cfDNA screening was offered to 11344 pregnant women...
June 18, 2018: European Journal of Medical Genetics
https://www.readbyqxmd.com/read/29928956/comparison-of-right-and-left-ventricular-enhancement-times-using-a-microbubble-contrast-agent-between-proximal-humeral-intraosseous-access-and-brachial-intravenous-access-during-cardiopulmonary-resuscitation-in-adults
#15
Yongchul Cho, Yeonho You, Jung Soo Park, Jin Hong Min, Insool Yoo, Wonjoon Jeong, Seung Ryu, Jinwoong Lee, Seungwhan Kim, Sung Uk Cho, Se Kwang Oh, Junwan Lee, Hong Joon Ahn
AIM: The present study aimed to compare the ventricular enhancement time between humeral intraosseous access (HIO) and brachial intravenous access (BIV) during cardiopulmonary resuscitation (CPR) in adult humans. To our knowledge, this is the first such study during CPR in adult humans. METHODS: This prospective single-centre observational cohort study assessed the medical records of patients who underwent CPR between January 2018 and March 2018. The primary endpoints were the left and right ventricular enhancement (LVE and RVE, respectively) times after administration of a microbubble contrast agent via HIO or BIV...
June 18, 2018: Resuscitation
https://www.readbyqxmd.com/read/29928955/effects-of-different-durations-of-sustained-inflation-during-cardiopulmonary-resuscitation-on-return-of-spontaneous-circulation-and-hemodynamic-recovery-in-severely-asphyxiated-piglets
#16
J Mustofa, P-Y Cheung, S Patel, T F Lee, M Lu, M P Pasquin, M OʼReilly, G M Schmölzer
OBJECTIVE: We previously demonstrated that sustained inflation (SI) during chest compression (CC) significantly reduces time to return of spontaneous circulation (ROSC) when compared to 3:1 compression:ventilation (C:V) ratio during neonatal resuscitation. However, the optimal length of SI during CC to improve ROSC and hemodynamic recovery in severely asphyxiated piglets is unknown. AIM: To examine if different lengths of SI will improve ROSC and hemodynamic recovery in severely asphyxiated piglets...
June 18, 2018: Resuscitation
https://www.readbyqxmd.com/read/29928917/carbon-nanotube-lipase-hybrid-nanoflowers-with-enhanced-enzyme-activity-and-enantioselectivity
#17
Kai Li, Jianhua Wang, Yaojia He, Miaad Adnan Abdulrazaq, Yunjun Yan
Various nanoflowers are synthesized as supports for different methods of enzyme immobilization; however, the activities of these immobilized enzymes are limited because of their confinement in the nanoflowers. In order to increase the performance of nanoflowers, in this study, different protein-phosphate hybrid nanostructures were successfully synthesized and further enhanced by carbon nanotubes (CNTs) under the same conditions. Only Cu3 (PO4 )2 complex nanostructures exhibited flower-like structures and showed excellent results after enhancement with CNTs in this framework...
June 18, 2018: Journal of Biotechnology
https://www.readbyqxmd.com/read/29928898/transient-high-pressure-in-pancreatic-ducts-promotes-inflammation-and-alters-tight-junctions-via-calcineurin-signaling-in-mice
#18
Li Wen, Tanveer A Javed, Dean Yimlamai, Amitava Mukherjee, Xiangwei Xiao, Sohail Z Husain
BACKGROUND AND AIMS: Pancreatitis following endoscopic retrograde cholangiopancreatography (PEP) is thought to be provoked by pancreatic ductal hypertension, via unknown mechanisms. We investigated the effects of hydrostatic pressures on the development of pancreatitis in mice. METHODS: We performed studies with Swiss Webster mice, B6129 mice (controls), and B6129 mice with disruption of the protein phosphatase 3, catalytic subunit, beta isoform gene (Cnab-/- mice)...
June 18, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29928884/lactic-acid-induces-lactate-transport-and-glycolysis-oxphos-interconversion-in-glioblastoma
#19
Ke Duan, Zhong-Jian Liu, Su-Qiong Hu, Hong-Yu Huo, Zhi-Ru Xu, Jian-Fei Ruan, Yang Sun, Li-Ping Dai, Chang-Bao Yan, Wei Xiong, Qing-Hua Cui, Hai-Jing Yu, Min Yu, Yang Qin
The Warburg effect is a dominant phenotype of most tumor cells. Recent reports have shown that the Warburg effect can be reprogrammed by the tumor microenvironment. Lactic acidosis and glucose deprivation are the common adverse microenvironments in solid tumor. The metabolic reprogramming induced by lactic acid and glucose deprivation remains to be elucidated in glioblastoma. Here, we show that, under glucose deprivation, lactic acid can preserve high ATP levels and resist cell death in U251 cells. At the same time, we find that MCT1 and MCT4 are significantly highly expressed...
June 18, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29928796/novel-cu-ii-edta-decomplexation-by-discharge-plasma-oxidation-and-coupled-cu-removal-by-alkaline-precipitation-underneath-mechanisms
#20
Tiecheng Wang, Yang Cao, Guangzhou Qu, Qiuhong Sun, Tianjiao Xia, Xuetao Guo, Hanzhong Jia, Lingyan Zhu
Strong complexation between heavy metals and organic complexing agents makes the heavy metals difficult to be removed by classical chemical precipitation. In this study, a novel decomplexation method was developed using discharge plasma oxidation, which was followed by alkaline precipitation to treat water containing heavy metal-organic complex, i.e., Cu-ethylenediaminetetraacetic acid (Cu-EDTA). The decomplexation efficiency of Cu complex reached up to nearly 100% after 60 min's oxidation by discharge plasma, which was accompanied by 82...
June 21, 2018: Environmental Science & Technology
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