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urine hemosiderin

Adolfo Flores, George R Buchanan
Little is known about the frequency and significance of clinically unapparent or occult hemorrhage in ITP. Therefore, we prospectively explored the sites and frequency of occult bleeding in children with severe ITP at diagnosis or upon symptomatic relapse in a prospective, single-institution cohort study of patients ≤ 18 years of age and a platelet count ≤ 10,000/mm(3) . Data collected included bleeding severity assessment, urinalysis, fecal occult blood testing, and non-contrast brain MRI. Stool and urine samples were tested within 7 days of diagnosis or symptomatic relapse...
March 2016: American Journal of Hematology
Dima Hamideh, Vimal Raj, Thomas Harrington, Hua Li, Emilio Margolles, Folasade Amole, Monica Garcia-Buitrago, Phillip Ruiz, Gaston Zilleruelo, Ofelia Alvarez
BACKGROUND: Although hyperfiltration and albuminuria are common pathological conditions, kidney injury (KI) biomarkers have been seldom studied in individuals with sickle cell anemia (SCA). METHODS: We undertook a cross-sectional assessment of urine KI biomarkers in children and adults with SCA with and without albuminuria and a normal estimated glomerular filtration rate (eGFR). Albumin, KI molecule 1 (KIM-1), N-acetyl-ß-D-glucosaminidase (NAG), endothelin-1 and transforming growth factor-β1 (TGF-β1) were measured...
October 2014: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
S Hussain, A Qureshi, J Kazi
Renal involvement in paroxysmal nocturnal hemoglobinuria (PNH) is not usually apparent but in cases with clinical involvement varies from reversible acute dysfunction to chronic irreversible damage. Early diagnosis and treatment is crucial to prevent disease progression and irreversible chronic kidney disease (CKD). The ultimate outcome of CKD in many patients is the need for renal replacement therapy, which necessitates ever-growing dialysis and transplantation programs, thereby imposing a significant economic burden on the healthcare system...
2013: Nephron. Clinical Practice
S Bhatia, M S Tullu, P Vaideeswar, K R Lahiri
Idiopathic pulmonary hemosiderosis (IPH) is a rare disorder (triad of iron-deficiency anemia, hemoptysis, and alveolar infiltrates). A 3-year-old male presented with mild fever, breathlessness, dry cough, and bluish nail discoloration for 8 days. He had required five blood transfusions in the past 1 year (last transfusion was given 4 months ago). He had a respiratory rate of 58/min with respiratory distress, cyanosis, and grade III clubbing. Respiratory system examination was normal. Several previous reports of hemoglobin were as low as 3...
January 2011: Journal of Postgraduate Medicine
Ka Qi, Xue-Guang Zhang, Shu-Wen Liu, Zhong Yin, Xiang-Mei Chen, Di Wu
The authors report a 57-year-old male patient who presented with diarrhea, darkened urine, jaundice and increased blood urea nitrogen and creatinine. Initially, his symptoms, which included hemolytic anemia, acute renal failure and low platelet count, seemed to be caused by renal injuries associated with thrombotic microangiopathy, hemolytic-uremic syndrome in particular. However, a renal biopsy indicated acute tubular necrosis and hemosiderin deposition. A CD55 and CD59 assay, Ham test and sugar-water hemolysis test confirmed the diagnosis of paroxysmal nocturnal hemoglobinuria...
January 2011: American Journal of the Medical Sciences
H E Harrison, H Bunting, N K Ordway, W S Albrink
Severe and persistent impairment of kidney function has been produced in dogs by intravascular hemolysis due to arsine, or by the intravenous injection of solutions of dog hemoglobin and methemoglobin. The kidneys of these animals have been examined by the usual histological methods and also by means of the ferrocyanide histochemical method to determine the pathogenesis of the renal injury. These observations indicate that obstruction to flow of urine through the renal tubules is an important factor in the early reduction of kidney function...
September 30, 1947: Journal of Experimental Medicine
E B Krumbhaar, A Chanutin
1. The effects of repeated transfusions of blood on the blood-destroying and blood-forming apparatus of normal and splenectomized dogs and rabbits have been described. An anemia which developed despite continued blood transfusions in two dogs splenectomized during plethora has also been studied. 2. The decrease or absence of reticulocytes from the blood stream during plethora and their increase during "plethoric anemia" are evidently due to depression and activation of bone marrow activity. The response of the bone marrow is not immediate upon the onset of anemia, but is delayed for several days...
May 31, 1922: Journal of Experimental Medicine
P Rous
In diseases which bring about a siderosis of the kidney there are ordinarily present in the urinary sediment cells containing granules of hemosiderin, and often many free granules as well. The finding has proved useful in the diagnosis of hemochromatosis and will probably be of service in the recognition of pernicious anemia, and possibly some other diseases. But in this relation the fact should be emphasized that urinary siderosis, as one may term it, is the indication of a renal condition, not of a disease...
October 31, 1918: Journal of Experimental Medicine
Tomoaki Harada, Eisuke Kimura, Mutsuko Hirata-Koizumi, Akihiko Hirose, Eiichi Kamata, Makoto Ema
Twelve male and female rats per group were given 4-aminophenol (PAP) by gavage at 0, 20, 100, or 500 mg/kg/day. Males were dosed for a total of 49 days, beginning 14 days before mating. Females were dosed for a total of 40-60 days, from 14 days before mating to Day 3 of lactation throughout the mating and gestation periods. Four males and 2 females died at 500 mg/kg/day, and all surviving males and females showed brown urine at 100 mg/kg/day and above. Body-weight gain was lower in males and females at 500 mg/kg/day, and food consumption was decreased in males at 500 mg/kg/day and in females at 100 and 500 mg/kg/day...
2008: Drug and Chemical Toxicology
Rahul Naithani, Manoranjan Mahapatra, Pankhi Dutta, Rajat Kumar, Hara Prasad Pati, Ved Prakash Choudhry
OBJECTIVE: To assess the clinical and hematological profile of PNH in children. METHODS: Clinical and laboratory features of children with PNH diagnosed in the past six years at our centre were reviewed. Various investigations done included a complete blood count and peripheral smear examination, plasma hemoglobin, urine hemosiderin, acid ham test, sucrose lysis test, immunophenotyping of erythrocytes by sephadex column gel card and of granulocytes by flow cytometry...
June 2008: Indian Journal of Pediatrics
Hiroyuki Ohsaki, Reiji Haba, Toru Matsunaga, Muneo Nakamura, Hideyasu Kiyomoto, Eiichiro Hirakawa
OBJECTIVE: To investigate the morphologic characteristics and immunocytochemical reaction to vimentin of the reactive renal tubular cells (RRTCs) in renal glomerular disease. STUDY DESIGN: We prospectively evaluated the urine cytology of renal glomerular disease in 40 patients who underwent renal biopsy. The cytology and renal biopsy specimens were analyzed for vimentin immunostaining. RESULTS: A total of 40 urine samples from the 40 patients were cytologically analyzed, and RRTCs were found in 25 samples (25 of 40, 62...
May 2008: Acta Cytologica
Szu-Chia Chen, Chi-Chih Hung, Chung-Pang Hsu, Yi-Wen Chiu, Yi-Chang Liu, Jer-Chia Tsai, Hung-Chun Chen
Acute renal failure (ARF) is one of the renal expressions in patients with aplastic anemia (AA)-paroxysmal nocturnal hemoglobinuria (PNH) syndrome following hemolytic crisis. We report the case of an AA patient who experienced recurrent episodes of ARF, in association with evidence of PNH. A 46-year-old woman with AA was admitted because of oliguria and dark urine following a urinary tract infection (UTI) caused by Candida. PNH with ARF complication was diagnosed. Hemodialysis treatment was performed nine times and her renal function recovered...
November 2007: Kaohsiung Journal of Medical Sciences
J Tan, A Smith, S Abisi, D Eastham, K G Burnand
OBJECTIVE: The aim of this study was to assess the relationship between urinary and tissue haemosiderin in chronic leg ulcers, and its value as a diagnostic test for venous ulceration. METHODS: 45 patients with chronic leg ulcers were recruited to the study (24 venous, 6 ischaemic, 6 lymphoedematous, 5 rheumatoid and 4 sickle cell). Punch biopsy of the ulcer edge was taken and early morning urine samples were collected. Positive Prussian-blue urinary haemosiderin granules were measured with a haemocytometer following Perls' staining...
September 2007: European Journal of Vascular and Endovascular Surgery
Kenichi Kato, Takanori Shibata, Kazumitsu Mukai, Kozo Kitazawa, Tetsuzo Sugisaki
A 60-year-old man, who had been diagnosed as having paroxysmal nocturnal hemoglobinuria(PNH) in 1994, was admitted to our hospital with general fatigue, and dark urine after a common-cold in January 2001. In the peripheral blood, the red blood cell count was 136 x 10(4)/microl, hemoglobin 4.0 g/dl and hematocrit 12.4%. The serum creatinine level was 9.9 mg/dl. Kidney biopsy revealed focal and segmental proliferation of mesangial cells, mesangial matrix expansion, acute tubular necrosis, interstitial fibrosis and hemosiderine deposits in the tubular epithelial cells confirmed by Berlin-blue staining...
2005: Nihon Jinzo Gakkai Shi
M C Lurá, M B Fuentes, M Cabagna, A M González, A F Nepote, M C Giugni, M Rico, M G Latorre
The aims of this work were to study the influence of secondary metabolites produced by a Penicillium citrinum strain. Mus musculus mice were fed with a diet containing those metabolites to determine both its influence on their development and the pathological and biochemical changes on experimental animals. Male and female including pregnant females, were studied. One group received commercial feed (A.B.) to which the citrinin- producing mould had been added (LF), another received A.B. contaminated with commercial citrinin (LC)...
December 2001: Revista Iberoamericana de Micología
C R McHenry, F Paras, Y C Liu, M Rodgers
OBJECTIVE: To describe a case of acute suppurative thyroiditis and focal abscess formation in a patient with a primary intrathoracic goiter. METHODS: We summarize the initial clinical manifestations, the pathologic findings, and the surgical treatment of a woman with an enlarging mediastinal mass. RESULTS: A 41-year-old woman had a fever and a sudden increase in severity of compressive symptoms after a remote urinary tract infection. Smears from an intraoperative fine-needle aspiration biopsy showed necrotic debris, polymorphonuclear leukocytes, hemosiderin-laden macrophages, and degenerated follicular epithelial cells...
January 1997: Endocrine Practice
Birsen Unal, Halil Basar, Miyace Y Karadeniz Bilgili, Murat Basar, Ertan Batislam, Haydar Hüseyin Erdal, Simay Kara
We present the case of a late-onset urinoma in a 47-year-old man with a history of right ureterolithotomy performed 6 months previously, following 2 unsuccessful attempts at extracorporeal shock wave lithotripsy. The ipsilateral kidney was nonfunctional and hydronephrotic. The urinoma did not show enhancement on contrast-enhanced CT and intravenous pyelography. Sonography revealed turbulence in the urinoma and jet flow from the ureter. Lab studies of fluid obtained by percutaneous puncture and aspiration yielded misleading findings for urine and revealed the presence of hemosiderin-laden macrophages...
June 2004: Journal of Clinical Ultrasound: JCU
No abstract text is available yet for this article.
January 6, 1964: Comptes Rendus Hebdomadaires des Séances de L'Académie des Sciences
No abstract text is available yet for this article.
January 13, 1964: Minerva Medica
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