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https://www.readbyqxmd.com/read/29343146/induction-of-labor-in-cases-of-late-preterm-isolated-oligohydramnios-is-it-justified
#1
Noa A Brzezinski-Sinai, Moshe Stavsky, Tal Rafaeli-Yehudai, Maayan Yitshak-Sade, Isaac Brzezinski-Sinai, Majdi Imterat, Salvatore Andrea Mastrolia, Offer Erez
OBJECTIVES: To analyze in a retrospective cohort study the outcomes of pregnancies with isolated oligohydramnios at the late preterm period (34-36.6 weeks of gestation). STUDY DESIGN: This retrospective cohort study included three groups of women: 1) Women with isolated oligohydramnios whose pregnancy was managed conservatively (n = 33 births); 2) women with isolated oligohydramnios who were managed actively (ie induction of labor) (n = 111 births); and 3) a control group including women with normal amount of amniotic fluid who had a spontaneous late preterm delivery (n = 10 445 births)...
January 17, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29339049/genotype-and-homology-analysis-of-pathogenic-and-colonization-strains-of-candida-albicans-from-hospitalized-neonates
#2
Jin-Zhen Su, Yu-Lan Yang, Rong Rong, Ben-Qing Wu
BACKGROUND: To detect the genotypes of pathogenic and colonization Candida albicans strains and to reveal whether there was a homologous relationship between these strains. METHODS: Pathogenic and colonization isolates were collected from infants in the NICU of Shenzhen People's Hospital (Shenzhen, People's Republic of China). rDNA identification, multilocus sequence typing (MLST), and multi-loci variable number tandem repeat analysis (MLVA) were used for species confirmation, strain identification, phylogenetic tree clustering, and assessment of homology among the pathogenic and colonization strains...
December 26, 2017: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/29330015/mother-to-child-transmission-of-extended-spectrum-beta-lactamase-producing-enterobacteriaceae
#3
Dana Danino, Rimma Melamed, Batya Sterer, Nurith Porat, Guy Hazan, Alex Gushanski, Eilon Shany, David Greenberg, Avraham Borer
BACKGROUND: Preterm infants are at high risk for extended spectrum beta-lactamase producing Enterobacteriaceae (ESBL-E) sepsis and neonatal intensive care unit (NICU) outbreaks. Maternal colonization with ESBL-E may be precursory to maternal-neonatal transmission. However, there is no consensus regarding surveillance of pregnant women for ESBL-E colonization. AIM: To identify pairs of mothers and offspring harbouring same-strain ESBL-E colonization and to determine whether maternal transmission may play a role in increasing ESBL-E carriage in preterm infants...
January 9, 2018: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29315356/il22-prevents-lipopolysaccharide-induced-preterm-labor-in-mice
#4
Svetlana Dambaeva, Sylvia Schneiderman, Mukesh K Jaiswal, Varkha Agrawal, Gajendra Katara, Alice Gilman-Sachs, Emmet Hirsch, Kenneth D Beaman
Preterm birth is widespread and causes 35% of all neonatal deaths. Infants who survive face potential long-term complications. A major contributing factor of preterm birth is infection. We investigated the role of Interleukin 22 (IL22) as a potential clinically relevant cytokine during gestational infection. IL22 is an effector molecule secreted by immune cells. While the expression of IL22 was reported in normal non-pregnant endometrium and early pregnancy decidua, little is known about uterine IL22 expression during mid- or late gestational stages of pregnancy...
January 5, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29314334/wheezing-and-infantile-colic-are-associated-with-neonatal-antibiotic-treatment
#5
Berthe C Oosterloo, Ruurd M van Elburg, Nicole B Rutten, Carin M Bunkers, Clarissa E Crijns, Clemens B Meijssen, Johanna H Oudshoorn, Ger T Rijkers, Cornelis K van der Ent, Arine M Vlieger
BACKGROUND: Cohort studies have suggested that early life antibiotic treatment is associated with increased risk of atopy. We determined whether antibiotic treatment already in the first week of life increases the risk for atopic and non-atopic disorders. METHODS: The INCA study is a prospective observational birth cohort study of 436 term infants, with follow-up of one year. 151 neonates received broad-spectrum antibiotics for suspected neonatal infection (AB+), versus a healthy untreated control group (N=285) (AB-)...
January 4, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29311619/in-situ-immune-response-and-mechanisms-of-cell-damage-in-central-nervous-system-of-fatal-cases-microcephaly-by-zika-virus
#6
Raimunda S S Azevedo, Jorge R de Sousa, Marialva T F Araujo, Arnaldo J Martins Filho, Bianca N de Alcantara, Fernanda M C Araujo, Maria G L Queiroz, Ana C R Cruz, Beatriz H Baldez Vasconcelos, Jannifer O Chiang, Lívia C Martins, Livia M N Casseb, Eliana V da Silva, Valéria L Carvalho, Barbara C Baldez Vasconcelos, Sueli G Rodrigues, Consuelo S Oliveira, Juarez A S Quaresma, Pedro F C Vasconcelos
Zika virus (ZIKV) has recently caused a pandemic disease, and many cases of ZIKV infection in pregnant women resulted in abortion, stillbirth, deaths and congenital defects including microcephaly, which now has been proposed as ZIKV congenital syndrome. This study aimed to investigate the in situ immune response profile and mechanisms of neuronal cell damage in fatal Zika microcephaly cases. Brain tissue samples were collected from 15 cases, including 10 microcephalic ZIKV-positive neonates with fatal outcome and five neonatal control flavivirus-negative neonates that died due to other causes, but with preserved central nervous system (CNS) architecture...
January 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29300158/vaccination-of-sows-with-a-dendritic-cell-targeted-porcine-epidemic-diarrhea-virus-s1-protein-based-candidate-vaccine-reduced-viral-shedding-but-exacerbated-gross-pathological-lesions-in-suckling-neonatal-piglets
#7
Sakthivel Subramaniam, Danielle M Yugo, C Lynn Heffron, Adam J Rogers, Harini Sooryanarain, Tanya LeRoith, Christopher Overend, Dianjun Cao, Xiang-Jin Meng
Porcine epidemic diarrhea virus (PEDV) poses a serious threat to swine worldwide as evidenced by its recent introduction into the USA and the devastating economic impact it caused to the USA swine industry. Commercial vaccines against PEDV are available but their efficacies are inadequate. Therefore, vaccines with improved efficacy are needed to effectively control PEDV infections. We previously determined the immunogenicity of a novel dendritic cell (DC)-targeted PEDV S1 protein-based subunit vaccine in weaned piglets in which the PEDV antigen was targeted to DCs through a porcine Langerin-specific antibody...
January 4, 2018: Journal of General Virology
https://www.readbyqxmd.com/read/29298456/a-double-blind-randomized-placebo-controlled-trial-of-17-alpha-hydroxyprogesterone-caproate-in-the-management-of-preterm-premature-rupture-of-membranes
#8
Elizabeth S Langen, Anita Sit, Katie Sherwin, Deirdre J Lyell, Yair J Blumenfeld, Yasser Y El-Sayed
OBJECTIVE:  The objective of this study was to evaluate whether weekly administration of 17 α-hydroxyprogesterone caproate (17-OHPC) increases the number of women who achieve 34 weeks of gestation after preterm premature rupture of membranes (PPROM). STUDY DESIGN:  We conducted a multicenter double-blind, randomized controlled trial of 17-OHPC versus placebo among women with PPROM. Women with singleton pregnancy, clinically confirmed PPROM, and without evidence of active infection or major fetal malformation between 240/7 and 320/7 weeks of pregnancy were offered enrollment...
January 3, 2018: American Journal of Perinatology
https://www.readbyqxmd.com/read/29290292/mathematical-modeling-of-porcine-epidemic-diarrhea-virus-dynamics-within-a-farrow-to-finish-swine-farm-to-investigate-the-effects-of-control-measures
#9
Kiyokazu Murai, Sachiko Moriguchi, Yoko Hayama, Sota Kobayashi, Ayako Miyazaki, Toshiyuki Tsutsui, Takehisa Yamamoto
Porcine epidemic diarrhea (PED) is a highly contagious enteric disease in swine that can cause devastating economic damage to pig producers. Japan was severely affected by PED epidemics from 2013 through 2015, with over 1000 farms were affected during this period. Although many studies have unraveled pathological and molecular characteristics of PED virus (PEDV), the mechanism for within-farm spread is largely unknown. Here, we constructed a deterministic compartmental model to quantitatively describe the infection dynamics in a farm setting and to investigate effective control measures...
January 1, 2018: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/29281927/neonatal-screening-for-congenital-cmv-infection-stresses-the-importance-of-maternal-nonprimary-infection-even-in-an-area-where-prenatal-serology-testing-is-common
#10
Vassiliki Papaevangelou, Zoi Christoni, Christianna Vliora, Christine Kottaridi, Aikaterini Fotiou, Ariadne Malamitsi-Puchner, Andreas Mentis, Petros Karakitsos, Angeliki Syggelou
AIM AND METHODS: Dried blood spots from 2149 newborns were examined to diagnose congenital cytomegalovirus (cCMV). RESULTS: Prenatal CMV-IgG antibodies had been measured during prenatal care in 1287 (60.3%) of mothers and 980 (76.1%) of them were found seropositive. cCMV incidence was 0.47%. All newborns were asymptomatic; 9/10 were born post nonprimary maternal infection; two developed sensorineural hearing loss. CONCLUSIONS: In a country where prenatal CMV testing is common and therefore a false sense of control might prevail, nonprimary maternal infection should not be overlooked...
December 27, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29278644/endothelial-cells-of-extremely-premature-infants-display-impaired-immune-response-after-proinflammatory-stimulation
#11
Lukas Wisgrill, Martina Muck, Isabelle Wessely, Angelika Berger, Andreas Spittler, Elisabeth Förster-Waldl, Kambis Sadeghi
BACKGROUND: Endothelial cells (ECs) exert immunological functions such as production of proinflammatory cytokines/chemokines as well as facilitation of extravasation of immune cells into infected tissue. Limited data are available on the functionality of ECs from extremely preterm neonates during infection. Accordingly, the aim of our study was to investigate the immune response of premature ECs after proinflammatory stimulation. METHODS: Cell adhesion receptors expression and function, NFkB-signaling and chemokine production were analyzed in umbilical cord ECs from extremely preterm and term neonates after proinflammatory stimulation...
August 21, 2017: Pediatric Research
https://www.readbyqxmd.com/read/29274431/trajectory-of-inflammatory-and-microglial-activation-markers-in-the-postnatal-rabbit-brain-following-intrauterine-endotoxin-exposure
#12
Zhi Zhang, Amar Jyoti, Bindu Balakrishnan, Monica Williams, Sarabdeep Singh, Diane C Chugani, Sujatha Kannan
BACKGROUND: Maternal infection is a risk factor for periventricular leukomalacia and cerebral palsy (CP) in neonates. We have previously demonstrated hypomyelination and motor deficits in newborn rabbits, as seen in patients with cerebral palsy, following maternal intrauterine endotoxin administration. This was associated with increased microglial activation, primarily involving the periventricular region (PVR). In this study we hypothesized that maternal intrauterine inflammation leads to a pro-inflammatory environment in the PVR that is associated with microglial activation in the first 2 postnatal weeks...
December 20, 2017: Neurobiology of Disease
https://www.readbyqxmd.com/read/29274345/risk-factors-for-imipenem-resistant-pseudomonas-aeruginosa-in-neonatal-intensive-care-units-in-south-china
#13
Yunbei Rao, Zhuxiao Ren, Junjuan Zhong, Xiuming Zhong, Bei Cao, Dongmei Chen, Xinnian Pan, Yanping Jia, Pingming Gao, Bingyan Yang, Qiao Zhong, Jie Yang
This multi-centre retrospective study was designed to investigate the risk factors for infection with imipenem-resistant Pseudomonas aeruginosa (IRPA) in Neonatal Intensive Care Units (NICU) in south China. All patients with confirmed P. aeruginosa infection from 8 NICU in south China were divided into two groups: imipenem-susceptible P. aeruginosa (ISPA) and IRPA. Chi-square test and logistic regression model were performed for statistical analyses. A total of 188 medical records were reviewed. In multivariate logistic analysis, imipenem treatment within two weeks of isolation of PA was the only independent risk factor (OR=6...
December 20, 2017: Journal of Hospital Infection
https://www.readbyqxmd.com/read/29251369/association-of-polymorphism-in-the-vegfa-gene-3-utr-936t-c-with-susceptibility-to-biliary-atresia-in-a-southern-chinese-han-population
#14
Fei Liu, Jixiao Zeng, Deli Zhu, Ruizhong Zhang, Xiaogang Xu, Mengmeng Wang, Yan Zhang, Huimin Xia, Zhichun Feng
BACKGROUND: Biliary atresia (BA) is a neonatal disease characterized by chronic inflammation of the bile ducts and progressive aggravation of jaundice, but with a poor prognosis and high mortality. The etiology of BA is still uncertain which may be related to gene defect, virus infection, immune disorder, gene polymorphism. As a proinflammatory cytokine, VEGFA gene polymorphism (rs3025039) has been shown to be related to the pathogenesis of BA in Taiwanese population. METHODS: We investigated the association between VEGFA gene polymorphism (rs3025039) and BA susceptibility using the largest case-control cohort, totaling with 506 BA patients and 1473 healthy controls in a Southern Chinese Han population...
December 18, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29249216/pathogen-distribution-and-antimicrobial-resistance-among-pediatric-healthcare-associated-infections-reported-to-the-national-healthcare-safety-network-2011-2014
#15
Jason G Lake, Lindsey M Weiner, Aaron M Milstone, Lisa Saiman, Shelley S Magill, Isaac See
OBJECTIVE To describe pathogen distribution and antimicrobial resistance patterns for healthcare-associated infections (HAIs) reported to the National Healthcare Safety Network (NHSN) from pediatric locations during 2011-2014. METHODS Device-associated infection data were analyzed for central line-associated bloodstream infection (CLABSI), catheter-associated urinary tract infections (CAUTI), ventilator-associated pneumonia (VAP), and surgical site infection (SSI). Pooled mean percentage resistance was calculated for a variety of pathogen-antimicrobial resistance pattern combinations and was stratified by location for device-associated infections (neonatal intensive care units [NICUs], pediatric intensive care units [PICUs], pediatric oncology and pediatric wards) and by surgery type for SSIs...
December 18, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29243512/the-relationship-between-hospital-construction-and-high-risk-infant-auditory-function-at-nicu-discharge-a-retrospective-descriptive-cohort-study
#16
Valerie Willis
PURPOSE: To describe the difference in auditory function at neonatal intensive care unit (NICU) discharge between high-risk infant cases exposed to hospital construction during NICU stay and those not exposed. BACKGROUND: Noise produced by routine NICU caregiving exceeds recommended intensity. As California hospitals undergo construction to meet seismic safety regulations, vulnerable neonates are potentially exposed to even higher levels of noise. Ramifications are unknown...
January 1, 2017: HERD
https://www.readbyqxmd.com/read/29242091/association-between-microcephaly-zika-virus-infection-and-other-risk-factors-in-brazil-final-report-of-a-case-control-study
#17
Thalia Velho Barreto de Araújo, Ricardo Arraes de Alencar Ximenes, Demócrito de Barros Miranda-Filho, Wayner Vieira Souza, Ulisses Ramos Montarroyos, Ana Paula Lopes de Melo, Sandra Valongueiro, Maria de Fátima Pessoa Militão de Albuquerque, Cynthia Braga, Sinval Pinto Brandão Filho, Marli Tenório Cordeiro, Enrique Vazquez, Danielle di Cavalcanti Souza Cruz, Claudio Maierovitch Pessanha Henriques, Luciana Caroline Albuquerque Bezerra, Priscila Mayrelle da Silva Castanha, Rafael Dhalia, Ernesto Torres Azevedo Marques-Júnior, Celina Maria Turchi Martelli, Laura Cunha Rodrigues
BACKGROUND: A Zika virus epidemic emerged in northeast Brazil in 2015 and was followed by a striking increase in congenital microcephaly cases, triggering a declaration of an international public health emergency. This is the final report of the first case-control study evaluating the potential causes of microcephaly: congenital Zika virus infection, vaccines, and larvicides. The published preliminary report suggested a strong association between microcephaly and congenital Zika virus infection...
December 11, 2017: Lancet Infectious Diseases
https://www.readbyqxmd.com/read/29234149/effect-of-maternal-iron-deficiency-anemia-on-fetal-neural-development
#18
Sriparna Basu, Dinesh Kumar, Shampa Anupurba, Ashish Verma, Ashok Kumar
OBJECTIVE: Perinatal iron deficiency may have deleterious consequences on fetal neural development. The present study was conducted to determine the effect of maternal iron deficiency anemia (IDA) on fetal hippocampal morphogenesis and production of brain-derived neurotrophic factor (BDNF). STUDY DESIGN: Seventy term, singleton neonates born to mothers with IDA (hemoglobin <110g/L and serum ferritin <12 μg/L) formed the study group. Twenty gestational age-matched neonates born to healthy mothers without IDA (hemoglobin ≥110 g/L and serum ferritin >12 μg/L) served as controls...
December 12, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29223959/performance-and-operational-characteristics-of-point-of-care-tests-for-the-diagnosis-of-urogenital-gonococcal-infections
#19
REVIEW
Rebecca J Guy, Louise M Causer, Jeffrey D Klausner, Magnus Unemo, Igor Toskin, Anna M Azzini, Rosanna W Peeling
BACKGROUND: In 2012, there was an estimated 78 million new cases of gonorrhoea globally. Untreated infection may lead to reproductive and neonatal morbidity and facilitate HIV transmission. Diagnosis and treatment are a priority for control and prevention, yet use of point-of-care tests (POCTs) for Neisseria gonorrhoeae (NG) is limited. OBJECTIVES: To review the performance and operational characteristics of NG POCTs for diagnosis of urogenital gonorrhoea. METHODS: We compiled and synthesised findings from two separate systematic reviews which included evaluations published until August 2015...
December 2017: Sexually Transmitted Infections
https://www.readbyqxmd.com/read/29218501/evaluating-safety-reporting-in-paediatric-antibiotic-trials-2000-2016-a-systematic-review-and-meta-analysis
#20
REVIEW
Paola Pansa, Yingfen Hsia, Julia Bielicki, Irja Lutsar, A Sarah Walker, Mike Sharland, Laura Folgori
BACKGROUND: There are very few options to treat multidrug-resistant bacterial infections in children. A major barrier is the duration and complexity of regulatory trials of new antibiotics. Extrapolation of safety data from adult trials could facilitate drug development for children. OBJECTIVE: We performed a systematic review on the safety of antibiotic clinical trials (CTs) in children (0-18 years) to evaluate the overall quality of safety trials conducted in children and to determine if age-specific adverse events (AEs) could be identified for specific antibiotic classes...
December 7, 2017: Drugs
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