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https://www.readbyqxmd.com/read/28533508/kinetic-interpretation-of-log-logistic-dose-time-response-curves
#1
Walter W Focke, Isbe van der Westhuizen, Ndeke Musee, Mattheüs Theodor Loots
A Hill-type time-response curve was derived using a single-step chemical kinetics approximation. The rate expression for the transformation is a differential equation that provides an interpolation formula between the logistic growth curve and second order kinetics. The solution is equivalent to the log-logistic cumulative distribution function with the time constant expressed in terms of a kinetic rate constant. This expression was extended to a full dose-time-response equation by postulating a concentration dependence for the rate constant...
May 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28521558/rising-utilization-of-inpatient-pediatric-asthma-pathways
#2
Sunitha V Kaiser, Jonathan Rodean, Arpi Bekmezian, Matt Hall, Samir S Shah, Sanjay Mahant, Kavita Parikh, Rustin Morse, Henry Puls, Michael D Cabana
INTRODUCTION: Clinical pathways are detailed care plans that operationalize evidence-based guidelines into an accessible format for health providers. Their goal is to link evidence to practice to optimize patient outcomes and delivery efficiency. It is unknown to what extent inpatient pediatric asthma pathways are being utilized nationally. OBJECTIVES: (1) Describe inpatient pediatric asthma pathway design and implementation across a large hospital network. (2) Compare characteristics of hospitals with and without pathways...
May 19, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28518065/transient-middle-cerebral-artery-occlusion-model-of-neonatal-stroke-in-p10-rats
#3
Amara Larpthaveesarp, Fernando F Gonzalez
A number of animal models have been used to study hypoxic-ischemic injury, traumatic injury, global hypoxia, or permanent ischemia in both the immature and mature brain. Stroke occurs commonly in the perinatal period in humans, and transient ischemia-reperfusion is the most common form of stroke in neonates. The reperfusion phase is a critical component of injury progression, which occurs over a period of days to weeks, and of the endogenous response to injury. This postnatal day 10 (p10) rat model of transient middle cerebral artery occlusion (tMCAO) creates a unilateral, non-hemorrhagic focal ischemia-reperfusion injury that can be utilized to study the mechanisms of focal injury and repair in the full-term-equivalent brain...
April 21, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28514641/mapping-workforce-configuration-and-operational-models-in-australian-emergency-departments-a-national-survey
#4
Glenn Gardner, Anne Gardner, Sandy Middleton, Julie Considine, Gerard Fitzgerald, Luke Christofis, Anna Doubrovsky, Margaret Adams, Jane O'Connell
Objective Hospital emergency departments (ED) in Australia and internationally have been experiencing increased demand, resulting in reduced hospital quality, impaired access and adverse health outcomes. Effective evaluation of new ED service models and their effect on outcomes is reliant on baseline measures of the staffing configuration and organisational characteristics of the EDs being studied. The aim of the present study was to comprehensively measure these variables in Australian EDs.Methods Australian hospital EDs with 24-h medical and nursing cover were identified and invited to participate in the study...
May 18, 2017: Australian Health Review: a Publication of the Australian Hospital Association
https://www.readbyqxmd.com/read/28511589/a-semi-automatic-method-for-the-extraction-of-the-portal-venous-input-function-in-quantitative-dynamic-contrast-enhanced-ct-of-the-liver
#5
Andrew B Gill, Nicholas J Hilliard, Simon T Hilliard, Martin Graves, David J Lomas, Ashley Shaw
OBJECTIVES: To aid the extraction of the portal venous input function (PVIF) from axial dynamic contrast-enhanced CT images of the liver, eliminating the need for full manual outlining of the vessel across time-points. METHODS: A cohort of 20 patients undergoing perfusion CT imaging of the liver were examined. Dynamic images of the liver were reformatted into contiguous thin slices. A region of interest (ROI) was defined within a transverse section of the portal vein on a single contrast-enhanced image...
May 16, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28487026/the-role-of-the-placenta-in-the-initiation-of-spiral-artery-remodelling-in-an-early-pregnant-chimpanzee-uterus
#6
L Vercruysse, A M Carter, R Pijnenborg
INTRODUCTION: In this study we evaluated the full extent of placental bed changes (centre to periphery) in a pregnant chimpanzee uterus, kept at the Museum for Central Africa in Tervuren, Belgium. According to placental size the specimen was equivalent to an 8 weeks pregnant human uterus. METHODS: Histological sections from central to peripheral tissue blocks of the placental bed were stained to reveal the presence of trophoblast, endothelium, vascular smooth muscle and elastic laminae...
May 2017: Placenta
https://www.readbyqxmd.com/read/28464930/comparative-costs-and-activity-from-a-sample-of-uk-clinical-trials-units
#7
Daniel Hind, Barnaby C Reeves, Sarah Bathers, Christopher Bray, Andrea Corkhill, Christopher Hayward, Lynda Harper, Vicky Napp, John Norrie, Chris Speed, Liz Tremain, Nicola Keat, Mike Bradburn
BACKGROUND: The costs of medical research are a concern. Clinical Trials Units (CTUs) need to better understand variations in the costs of their activities. METHODS: Representatives of ten CTUs and two grant-awarding bodies pooled their experiences in discussions over 1.5 years. Five of the CTUs provided estimates of, and written justification for, costs associated with CTU activities required to implement an identical protocol. The protocol described a 5.5-year, nonpharmacological randomized controlled trial (RCT) conducted at 20 centres...
May 2, 2017: Trials
https://www.readbyqxmd.com/read/28463260/investigation-of-axial-and-transverse-focal-spot-sizes-of-fresnel-zone-plates
#8
Tao Liu, Qiang Liu, Shuming Yang, Zhuangde Jiang, Tong Wang, Guofeng Zhang
An axial spot size formula is given for a standard binary Fresnel zone plate (FZP) illuminated with a linearly polarized beam. The axial spot size, characterized by the full width at half-maximum (FWHM), can be accurately expressed by the Jiang-Wilson formula, viz., d<sub>z</sub>=0.9λ<sub>0</sub>/[η-(η<sup>2</sup>-NA<sup>2</sup>)<sup>1/2</sup>], when the number of transparent annuli is no less than 3. λ<sub>0</sub> is the illumination light wavelength, η is the refractive index, and NA is the equivalent numerical aperture of a FZP...
May 1, 2017: Applied Optics
https://www.readbyqxmd.com/read/28462518/alvimopan-for-recovery-of-bowel-function-after-radical-cystectomy
#9
REVIEW
Shahnaz Sultan, Bernadette Coles, Philipp Dahm
BACKGROUND: Alvimopan is used in abdominal surgery to reduce postoperative ileus in patients undergoing small bowel resections with primary anastomosis. The role and efficacy of alvimopan in patients undergoing radical cystectomy with urinary diversion is not well understood. OBJECTIVES: To assess the effects of alvimopan in the context of enhanced recovery pathways compared to enhanced recovery pathways alone for perioperative bowel dysfunction in patients undergoing radical cystectomy...
May 2, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28454519/factors-affecting-the-accuracy-of-genomic-selection-for-growth-and-wood-quality-traits-in-an-advanced-breeding-population-of-black-spruce-picea-mariana
#10
Patrick R N Lenz, Jean Beaulieu, Shawn D Mansfield, Sébastien Clément, Mireille Desponts, Jean Bousquet
BACKGROUND: Genomic selection (GS) uses information from genomic signatures consisting of thousands of genetic markers to predict complex traits. As such, GS represents a promising approach to accelerate tree breeding, which is especially relevant for the genetic improvement of boreal conifers characterized by long breeding cycles. In the present study, we tested GS in an advanced-breeding population of the boreal black spruce (Picea mariana [Mill.] BSP) for growth and wood quality traits, and concurrently examined factors affecting GS model accuracy...
April 28, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28453824/professional-attitudes-toward-incident-reporting-can-we-measure-and-compare-improvements-in-patient-safety-culture
#11
Pierfrancesco Tricarico, Luigi Castriotta, Claudio Battistella, Fabrizio Bellomo, Giovanni Cattani, Lucrezia Grillone, Stefania Degan, Daniela De Corti, Silvio Brusaferro
Objective: To establish categories of professionals' attitudes toward incident reporting by analyzing the trends in incident reporting while accounting for general risk indicators. Design: The incident reporting system was evaluated over 6 years. Reporting rates, stratified by year and profession, were estimated using the non-mandatory reported events/full-time equivalent (NM-IR/FTE) rate. Other indicators were collected using the hospital's official database. Staff attitudes toward self-reporting were analyzed...
April 1, 2017: International Journal for Quality in Health Care
https://www.readbyqxmd.com/read/28450566/studies-of-a-next-generation-silicon-photomultiplier-based-time-of-flight-pet-ct-system
#12
David Fc Hsu, Ezgi Ilan, William T Peterson, Jorge Uribe, Mark Lubberink, Craig S Levin
This article presents system performance studies of the Discovery MI PET/CT system, a new time-of-flight (TOF) system based on silicon photomultipliers. System performance and clinical imaging comparisons were made between this next-generation system and other commercially available PET/CT and PET/MR systems, as well as between different reconstruction algorithms. Methods: Spatial resolution, sensitivity, NECR, scatter fraction, count rate accuracy, and image quality were characterized with the NEMA NU-2 2012 standards...
April 27, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28450560/high-contrast-pet-imaging-of-vasopressin-v1b-receptors-with-a-novel-radioligand-11-c-tasp699
#13
Kazumi Koga, Yuji Nagai, Masayuki Hanyu, Mitsukane Yoshinaga, Shigeyuki Chaki, Norikazu Ohtake, Satoshi Ozaki, Ming-Rong Zhang, Tetsuya Suhara, Makoto Higuchi
Vasopressin 1B receptors (V1BRs) are abundantly expressed in the pituitary, and in vivo positron emission tomography (PET) of V1BRs was recently enabled by our development of a specific radioligand, (11)C-TASP0434299, derivatized from pyridopyrimidin-4-one. Here, we identified a novel pyridopyrimidin-4-one analog, N-tert-butyl-2-[2-(6-(11)C-methoxypyridine-2-yl)-6-[3-(morpholin-4-yl)propoxy]-4-oxopyrido[2,3-d]pyrimidin-3(4H)-yl]acetamide ((11)C-TASP0410699, hereafter referred to as (11)C-TASP699), as a potent V1BR radioligand producing a higher image contrast for the target than (11)C-TASP0434299...
April 27, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28435753/does-hawai-i-have-enough-psychiatrists-assessing-mental-health-workforce-versus-demand-in-the-aloha-state
#14
Alexandra Aaronson, Kelley Withy
National data reports the number of adults with any diagnosable mental disorder within a given year is nearly 1 in 5. Hawai'i, along with the rest of the nation, faces a serious shortage of mental health providers. This article describes the research undertaken to create a more accurate assessment of the current mental health provider workforce in Hawai'i through developing an estimation strategy to appraise local mental health workforce needs. The results indicate the supply of psychiatrists for Hawai'i's 2010 census population was found to be 161...
March 2017: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/28435751/hawai-i-physician-workforce-assessment-2016-improvement-in-physician-numbers-but-physician-suicides-of-concern
#15
Kelley Withy, Priscilla Mapelli, John Perez, Ariel Finberg, Josh Green
Hawai'i's Physician Workforce Assessment project was launched in 2010. Over the past 5 years the State has experienced decreases and increases in physician workforce. This current article describes the status of the physician workforce, past trends and anticipated projections as well as recent insights into why people leave Hawai'i. Survey data, internet searches and direct dialing methodologies were utilized to clarify and elucidate practice location, full time equivalency of time providing patient care and specialty of non-military physicians caring for Hawai'i's population...
March 2017: Hawai'i Journal of Medicine & Public Health: a Journal of Asia Pacific Medicine & Public Health
https://www.readbyqxmd.com/read/28422085/resonant-rectifier-ics-for-piezoelectric-energy-harvesting-using-low-voltage-drop-diode-equivalents
#16
Amad Ud Din, Seneke Chamith Chandrathna, Jong-Wook Lee
Herein, we present the design technique of a resonant rectifier for piezoelectric (PE) energy harvesting. We propose two diode equivalents to reduce the voltage drop in the rectifier operation, a minuscule-drop-diode equivalent (MDDE) and a low-drop-diode equivalent (LDDE). The diode equivalents are embedded in resonant rectifier integrated circuits (ICs), which use symmetric bias-flip to reduce the power used for charging and discharging the internal capacitance of a PE transducer. The self-startup function is supported by synchronously generating control pulses for the bias-flip from the PE transducer...
April 19, 2017: Sensors
https://www.readbyqxmd.com/read/28421820/characteristics-associated-with-physical-activity-capacity-and-performance-in-children-and-adolescents-with-an-acquired-brain-injury
#17
Emmah Baque, Lee Barber, Leanne Sakzewski, Robert Ware, Roslyn N Boyd
AIM: To examine characteristics associated with physical activity capacity and performance in children with acquired brain injury (ABI). METHODS: 58 children (32 men; age 11 years 11 months ± 2 years 6 months; Gross motor function classification system [GMFCS] equivalent I = 29, II = 29) >12 months post ABI were recruited. Physical activity capacity measures included: (i) combined score of three 30-second repetition maximum functional strength exercises; (ii) timed up and go; (iii) 6-minute walk test and (iv) high-level mobility assessment tool (HiMAT)...
April 19, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28411738/implementing-powered-stretcher-and-load-systems-was-a-cost-effective-intervention-to-reduce-the-incidence-rates-of-stretcher-related-injuries-in-a-paramedic-service
#18
Daniel P Armstrong, Richard Ferron, Cindi Taylor, Brent McLeod, Steve Fletcher, Renée S MacPhee, Steven L Fischer
Paramedic services are considering moving towards the use of powered stretcher and load systems to reduce stretcher related injuries, but cost is perceived as a barrier. This study compared injury incidence rates, days lost, and compensation costs between Niagara Emergency Medical Service (NEMS) and Hamilton Paramedic Service (HPS) pre- (four years) and post- (one year) implementation of powered stretcher and load systems in NEMS. Prior to the intervention stretcher related musculoskeletal disorder (MSD) incidence rates averaged 20...
July 2017: Applied Ergonomics
https://www.readbyqxmd.com/read/28409557/randomised-controlled-trial-of-silk-therapeutic-garments-for-the-management-of-atopic-eczema-in-children-the-clothes-trial
#19
Kim S Thomas, Lucy E Bradshaw, Tracey H Sach, Fiona Cowdell, Jonathan M Batchelor, Sandra Lawton, Eleanor F Harrison, Rachel H Haines, Amina Ahmed, Taraneh Dean, Nigel P Burrows, Ian Pollock, Hannah K Buckley, Hywel C Williams, Joanne Llewellyn, Clare Crang, Jane D Grundy, Juliet Guiness, Andrew Gribbin, Eileen V Wake, Eleanor J Mitchell, Sara J Brown, Alan A Montgomery
BACKGROUND: Atopic eczema (AE) is a chronic, itchy, inflammatory skin condition that affects the quality of life of children and their families. The role of specialist clothing in the management of AE is poorly understood. OBJECTIVES: To assess the effectiveness and cost-effectiveness of silk garments for the management of AE in children with moderate to severe disease. DESIGN: Parallel-group, observer-blind, randomised controlled trial of 6 months' duration, followed by a 2-month observational period...
April 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/28406369/comparing-some-production-functions-for-inpatient-health-services-in-selected-public-hospitals-in-spain
#20
Manel Antelo, Francisco Reyes-Santiás, Carmen Cadarso-Suárez, María Xosé Rodríguez-Álvarez
To investigate the adequacy of the widely used Cobb-Douglas and transcendental logarithmic (translog) models of the production functions of hospital inpatient services, the authors fitted these and additive models to data for the four most productive health services of 10 public hospitals in Galicia, Spain (the same four in each). Production, measured as admissions weighted in accordance with their diagnosis-related groups (DRGs), was treated as a function of physician full-time equivalents as surrogate labor factor and number of beds as surrogate capital factor...
April 13, 2017: Hospital Topics
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