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https://www.readbyqxmd.com/read/29330300/real-time-imaging-of-yeast-cells-reveals-several-distinct-mechanisms-of-curing-of-the-ure3-prion
#1
Xiaohong Zhao, Jenna Lanz, Danielle Steinberg, Tyler Pease, Joseph M Ahearn, Evgeny E Bezsonov, Elena Staguhn, Evan Eisenberg, Daniel C Masison, Lois E Greene
The [URE3] yeast prion is the self-propagating amyloid form of the Ure2 protein. [URE3] is cured by overexpression of several yeast proteins, including Ydj1, Btn2, Cur1, Hsp42, and human DnaJB6. To better understand [URE3] curing, we used real-time imaging with a yeast strain expressing a GFP-labeled full-length Ure2 construct to monitor the curing of [URE3] over time. [URE3] yeast cells exhibited numerous fluorescent foci, and expression of the GFP-labeled Ure2 affected neither mitotic stability of [URE3] nor the rate of [URE3] curing by the curing proteins...
January 12, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29325835/synthetic-mesh-vs-allograft-extensor-mechanism-reconstruction-in-total-knee-arthroplasty-a-systematic-review-of-the-literature-and-meta-analysis
#2
REVIEW
David Shau, Ryan Patton, Suhag Patel, Laura Ward, George Guild
BACKGROUND: Extensor mechanism disruption after total knee arthroplasty (TKA) is a devastating complication. Reconstruction with allograft and synthetic mesh has been described. However, these reports have typically been small case series, and controversy exists with regard to which reconstruction technique is optimal. METHODS: The authors performed a systematic review using PUBMED, MEDLINE, EMBASE, BIOSIS, Clinicaltrials.gov, and Cochrane Database of Systematic Reviews identifying 14 articles meeting inclusion criteria and producing 204 knees for comparison...
January 8, 2018: Knee
https://www.readbyqxmd.com/read/29316477/challenges-of-diagnosing-fetal-alcohol-spectrum-disorders-in-foster-and-adopted-children
#3
Ludmila N Bakhireva, Laura Garrison, Shikhar Shrestha, Janet Sharkis, Rajesh Miranda, Karen Rogers
Fetal Alcohol Spectrum Disorders (FASD) might be 10-15 times more prevalent among foster/adopted children compared to the general population; however, many of these children remain undiagnosed or misdiagnosed. The lack of confirmed prenatal alcohol exposure (PAE) may be a key barrier to diagnosis. Our sample included 681 patients evaluated for FASD, according to the University of Washington 4-Digit Diagnostic Code, at a pediatric specialty clinic. Guardianship status and other patient characteristics were evaluated by multinomial logistic regression as potential predictors of being classified into one of the following FASD groups: 1) full or partial Fetal Alcohol Syndrome (FAS/pFAS; n = 97); 2) Static Encephalopathy/Alcohol-Exposed (SE/AE) or Neurobehavioral Disorder/Alcohol-Exposed (ND/AE) (n = 135); and 3) some features of FASD (equivalent to pFAS, SE/AE or ND/AE phenotypes) but unknown PAE (n = 449)...
August 24, 2017: Alcohol
https://www.readbyqxmd.com/read/29311202/coarse-graining-for-fast-dynamics-of-order-parameters-in-the-phase-field-model
#4
D Jou, P K Galenko
In standard descriptions, the master equation can be obtained by coarse-graining with the application of the hypothesis of full local thermalization that is equivalent to the local thermodynamic equilibrium. By contrast, fast transformations proceed in the absence of local equilibrium and the master equation must be obtained with the absence of thermalization. In the present work, a non-Markovian master equation leading, in specific cases of relaxation to local thermodynamic equilibrium, to hyperbolic evolution equations for a binary alloy, is derived for a system with two order parameters...
February 28, 2018: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
https://www.readbyqxmd.com/read/29289366/comparison-of-endoaortic-and-transthoracic-aortic-clamping-in-less-invasive-mitral-valve-surgery
#5
Cristina Barbero, Ralph Krakor, Mohamed Bentala, Filip Casselman, Pascal Candolfi, Jacques Goldstein, Mauro Rinaldi
BACKGROUND: Less-invasive mitral valve surgery has become a widespread procedure in recent years, although mode of perfusion and aortic clamping are still debated questions. The aim of this study was to compare the results between transthoracic aortic clamping (TTC) and endoaortic clamping (EAC) in a multicenter, retrospective study. METHODS: Data from 3 centers experienced in both TTC and EAC were retrospectively analyzed. Five hundred consecutive patients undergoing less-invasive mitral valve surgery received either TTC (n = 250) or EAC (n = 250)...
December 27, 2017: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29283244/bacterial-adhesion-is-effected-by-the-thickness-and-stiffness-of-poly-ethylene-glycol-hydrogels
#6
Kristopher W Kolewe, Jiaxin Zhu, Natalie R Mako, Stephen S Nonnenmann, Jessica D Schiffman
Despite lacking visual, auditory, and olfactory perception, bacteria sense and attach to surfaces. Many factors including, the chemistry, topography, and mechanical properties of a surface, are known to alter bacterial attachment, and in this study, using a library of nine protein-resistant poly(ethylene glycol) (PEG) hydrogels immobilized on glass slides, we demonstrate that the thickness or amount of polymer concentration also matters. Hydrated atomic force microscopy and rheological measurements corroborated that thin (15 µm), medium (40 µm), and thick (150 µm) PEG hydrogels possessed Young's moduli in three distinct regimes, soft (20 kPa), intermediate (300 kPa), and stiff (1000 kPa)...
December 28, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29279292/metrix-matrix-a-cloud-based-system-for%C3%A2-tracking-non-relative-value-unit-value-added-work-metrics
#7
Mark D Kovacs, Douglas H Sheafor, Paul G Thacker, Andrew D Hardie, Philip Costello
PURPOSE: In the era of value-based medicine, it will become increasingly important for radiologists to provide metrics that demonstrate their value beyond clinical productivity. In this article the authors describe their institution's development of an easy-to-use system for tracking value-added but non-relative value unit (RVU)-based activities. METHODS: Metrix Matrix is an efficient cloud-based system for tracking value-added work. A password-protected home page contains links to web-based forms created using Google Forms, with collected data populating Google Sheets spreadsheets...
December 23, 2017: Journal of the American College of Radiology: JACR
https://www.readbyqxmd.com/read/29273897/impact-of-flash-glucose-monitoring-on-hypoglycaemia-in-adults-with-type-1-diabetes-managed-with-multiple-daily-injection-therapy-a-pre-specified-subgroup-analysis-of-the-impact-randomised-controlled-trial
#8
Per Oskarsson, Ramiro Antuna, Petronella Geelhoed-Duijvestijn, Jens Krӧger, Raimund Weitgasser, Jan Bolinder
AIMS/HYPOTHESIS: Evidence for the effectiveness of interstitial glucose monitoring in individuals with type 1 diabetes using multiple daily injection (MDI) therapy is limited. In this pre-specified subgroup analysis of the Novel Glucose-Sensing Technology and Hypoglycemia in Type 1 Diabetes: a Multicentre, Non-masked, Randomised Controlled Trial' (IMPACT), we assessed the impact of flash glucose technology on hypoglycaemia compared with capillary glucose monitoring. METHODS: This multicentre, prospective, non-masked, RCT enrolled adults from 23 European diabetes centres...
December 23, 2017: Diabetologia
https://www.readbyqxmd.com/read/29258521/long-term-trends-in-supply-and-sustainability-of-the-health-workforce-in-remote-aboriginal-communities-in-the-northern-territory-of-australia
#9
Yuejen Zhao, Deborah J Russell, Steven Guthridge, Mark Ramjan, Michael P Jones, John S Humphreys, Timothy A Carey, John Wakerman
BACKGROUND: International evidence suggests that a key to improving health and attaining more equitable health outcomes for disadvantaged populations is a health system with a strong primary care sector. Longstanding problems with health workforce supply and turnover in remote Aboriginal communities in the Northern Territory (NT), Australia, jeopardise primary care delivery and the effort to overcome the substantial gaps in health outcomes for this population. This research describes temporal changes in workforce supply in government-operated clinics in remote NT communities through a period in which there has been a substantial increase in health funding...
December 19, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/29244224/osteochondral-repair-using-an-acellular-dermal-matrix-pilot-in-vivo-study-in-a-rabbit-osteochondral-defect-model
#10
Ken Ye, Kathy Traianedes, Shalley A Robins, Peter F M Choong, Damian E Myers
The aim of this pilot project was to introduce a novel use of acellular dermal matrix (ADM) in combination with infrapatellar fat pad mesenchymal stromal cells (IPFP-MSCs) to effect repair in a rabbit osteochondral defect model. ADM, in a range of surgical procedures, has been shown to promote remodelling of tissue at the site of implantation. Rabbit-derived ADM (rabADM) was prepared from the skin of donor rabbits. Autologous IPFP-MSCs were obtained at the time of knee surgery. Osteochondral defects (4mm cartilage outer/2mm central bone defect) were drilled into distal femoral condyles of 12 New Zealand White rabbits...
December 15, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29235440/leveraging-multi-layer-imager-detector-design-to-improve-low-dose-performance-for-megavoltage-cone-beam-computed-tomography
#11
Yue-Houng Hu, Joerg Rottmann, Rony Fueglistaller, Marios E Myronakis, Adam Wang, Pascal Huber, Daniel Shedlock, Daniel Morf, Paul Baturin, Josh M Star-Lack, Ross I Berbeco
While megavoltage (MV) cone-beam computed tomography (CBCT) using an electronic portal imaging device (EPID) provides many advantages over kilovoltage (kV) CBCT, clinical adoption is limited by its high doses. Multi-layer imager (MLI) EPIDs increase DQE(0) while maintaining high resolution. However, even well-designed, high-performance MLIs suffer from increased electronic noise from each readout, degrading low-dose image quality. To improve low-dose performance, shift-and-bin addition (ShiBA) imaging is proposed, leveraging the unique architecture of the MLI...
December 13, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/29227416/rurality-quality-improvement-maturity-and-accreditation-readiness-a-comparison-study-of-colorado-kansas-and-nebraska-local-health-departments
#12
Abbey Gregg, Sarbinaz Bekmuratova, David Palm, Lisa VanRaemdonck, Gianfranco Pezzino, Li-Wu Chen, Peter Manetta
OBJECTIVE: To compare local health department (LHD) accreditation readiness (AR) and quality improvement (QI) maturity in 3 states, between LHDs with varying levels of rurality, and across an LHD staffing-level continuum. DESIGN: This was a cross-sectional comparative study that included an online survey administered to LHD directors in Colorado, Kansas, and Nebraska. The survey included 10 questions assessed on a 5-point Likert scale covering 3 QI domains and 13 questions covering 5 AR domains...
December 7, 2017: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/29215912/an-australian-biobank-certification-scheme-a-study-of-economic-costs-to-participating-biobanks
#13
Rod Ling, Amanda Rush, Candace Carter, Jane Carpenter, Peter H Watson, Jennifer A Byrne, Andrew Searles
Biobanks face increasing demands for research materials of consistent quality, which can be used in collaborative studies. Several countries and some international agencies have made formal efforts to standardize biobank operations and outputs. These include the establishment of best practice guidelines for collection management, and certification programs. Such guidelines and programs increase biobanks' opportunities for participation in high impact research and funding. However, they also impose economic and time costs, which may burden biobanks...
December 7, 2017: Biopreservation and Biobanking
https://www.readbyqxmd.com/read/29193286/understanding-ed-performance-after-the-implementation-of-activity-based-funding
#14
Ghasem-Sam Toloo, John Burke, Julia Crilly, Ged Williams, Bridie McCann, Gerry FitzGerald, Anthony Bell
OBJECTIVE: The aim of this study was to describe emergency department (ED) activities and staffing after the introduction of activity-based funding (ABF) to highlight the challenges of new funding arrangements and their implementation. METHODS: A retrospective study of public hospital EDs in Queensland, Australia, was undertaken for 2013-2014. The ED and hospital characteristics are described to evaluate the alignment between activity and resourcing levels and their impact on performance...
November 29, 2017: International Journal of Health Planning and Management
https://www.readbyqxmd.com/read/29192363/quantitative-and-visual-assessments-toward-potential-sub-msv-or-ultrafast-fdg-pet-using-high-sensitivity-tof-pet-in-pet-mri
#15
Spencer C Behr, Emma Bahroos, Randall A Hawkins, Lorenzo Nardo, Vahid Ravanfar, Emily V Capbarat, Youngho Seo
PURPOSE: Newer high-performance time-of-flight (TOF) positron emission tomography (PET) systems have the capability to preserve diagnostic image quality with low count density, while maintaining a high raw photon detection sensitivity that would allow for a reduction in injected dose or rapid data acquisition. To assess this, we performed quantitative and visual assessments of the PET images acquired using a highly sensitive (23.3 cps/kBq) large field of view (25-cm axial) silicon photomultiplier (SiPM)-based TOF PET (400-ps timing resolution) integrated with 3 T-MRI in comparison to PET images acquired on non-TOF PET/x-ray computed tomography (CT) systems...
November 30, 2017: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29191374/-involuntary-psychiatric-care-for-inmates-in-france-only-for-dangerous-patients
#16
T Fovet, M Bertrand, M Horn, W Si Mohammed, D Dandelot, M-C Dalle, P Thomas, A Amad
The unités hospitalières spécialement aménagées (UHSA) are full-time inpatient psychiatric units for inmates in France. Their creation has been associated with several advances in access to psychiatric care for inmates in recent years. However, there is still only one means of involuntary hospitalization for prisoners in France: care by decision of a representative of the state (les soins sur décision d'un représentant de l'état [SDRE]). Interestingly, for SDRE to be recognized as legal by the French judge, the patient must be "a danger to himself or to the others"...
November 27, 2017: L'Encéphale
https://www.readbyqxmd.com/read/29190037/routine-antibiotic-prophylaxis-after-normal-vaginal-birth-for-reducing-maternal-infectious-morbidity
#17
REVIEW
Mercedes Bonet, Erika Ota, Chioma E Chibueze, Olufemi T Oladapo
BACKGROUND: Infectious morbidities contribute to considerable maternal and perinatal morbidity and mortality, including women at no apparent increased risk of infection. To reduce the incidence of infections, antibiotics are often administered to women after uncomplicated childbirth, particularly in settings where women are at higher risk of puerperal infectious morbidities. OBJECTIVES: To assess whether routine administration of prophylactic antibiotics to women after normal (uncomplicated) vaginal birth, compared with placebo or no antibiotic prophylaxis, reduces postpartum maternal infectious morbidities and improves outcomes...
November 13, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29171127/how-many-geriatricians-should-at-minimum-be-staffing-health-regions-in-australia
#18
Toby Commerford
In any particular region, determining an adequate, quantifiable geriatrician full-time equivalent required to run geriatric medicine services comprehensively - that is spanning both inpatient and outpatient settings - remains an imperfect science. Whilst workforce planning may be addressed through 'demand versus supply' simulations, 'specialist-to-patient ratios' (SPRs) may be a useful additional workforce metric. There has never been a yardstick SPR, which 'defines' a satisfactory level of geriatrician manpower in any particular Australian hospital catchment...
November 24, 2017: Australasian Journal on Ageing
https://www.readbyqxmd.com/read/29167063/intramuscular-administration-potentiates-extended-dwell-time-of-mesenchymal-stromal-cells-compared-to-other-routes
#19
Lorena R Braid, Catherine A Wood, Danielle M Wiese, Barry N Ford
BACKGROUND: Mesenchymal stromal cells (MSCs) offer great potential for diverse clinical applications. However, conventional systemic infusion of MSCs limits their therapeutic benefit, since intravenously (IV) infused cells become entrapped in the lungs where their dwell time is short. METHODS: To explore possible alternatives to IV infusion, we used in vivo optical imaging to track the bio-distribution and survival of 1 million bioluminescent MSCs administered IV, intraperitoneally (IP), subcutaneously (SC) and intramuscularly (IM) in healthy athymic mice...
November 19, 2017: Cytotherapy
https://www.readbyqxmd.com/read/29166319/cardiometabolic-impact-of-changing-sitting-standing-and-stepping-in-the-workplace
#20
Elisabeth Ah Winkler, Sebastien Chastin, Elizabeth G Eakin, Neville Owen, Anthony D LaMontagne, Marj Moodie, Paddy C Dempsey, Bronwyn A Kingwell, David W Dunstan, Genevieve N Healy
BACKGROUND: According to cross-sectional and acute experimental evidence, reducing sitting time should improve cardio-metabolic health risk biomarkers. Furthermore, the improvements obtained may depend on whether sitting is replaced with standing or ambulatory activities. Based on data from the Stand Up Victoria multi-component workplace intervention, we examined this issue using compositional data analysis - a method that can examine and compare all activity changes simultaneously. METHODS: Participants receiving the intervention (n=136 ≥0...
November 21, 2017: Medicine and Science in Sports and Exercise
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