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https://www.readbyqxmd.com/read/28740925/characterization-of-efficacy-and-toxicity-after-high-dose-pelvic-reirradiation-with-palliative-intent-for-genitourinary-second-malignant-neoplasms-or-local-recurrences-after-full-dose-radiation-therapy-in-the-pelvis-a-high-volume-cancer-center-experience
#1
Sophia C Kamran, Lauren C Harshman, Mandar S Bhagwat, Vinayak Muralidhar, Paul L Nguyen, Neil E Martin, Stephanie La Follette, Sarah Faso, Akila N Viswanathan, Jason A Efstathiou, Clair J Beard
PURPOSE: The use of large-field external beam reirradiation (re-RT) after pelvic radiation therapy (RT) for genitourinary (GU) cancers has not been reported. We report the results of such treatment in patients with either symptomatic GU second malignant neoplasms or locally recurrent pelvic tumors after initial RT for whom surgery or further systemic therapy was not an option. METHODS AND MATERIALS: The records of 28 consecutive patients with advanced, bulky GU malignancies treated with high-dose, large-field re-RT with palliative intent between 2008 and 2014 were retrospectively reviewed...
April 2017: Advances in Radiation Oncology
https://www.readbyqxmd.com/read/28733638/quantum-thermalization-and-the-expansion-of-atomic-clouds
#2
Louk Rademaker, Jan Zaanen
The ultimate consequence of quantum many-body physics is that even the air we breathe is governed by strictly unitary time evolution. The reason that we perceive it nonetheless as a completely classical high temperature gas is due to the incapacity of our measurement machines to keep track of the dense many-body entanglement of the gas molecules. The question thus arises whether there are instances where the quantum time evolution of a macroscopic system is qualitatively different from the equivalent classical system? Here we study this question through the expansion of noninteracting atomic clouds...
July 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28733155/implementation-of-a-health-information-exchange-into-community-pharmacy-workflow
#3
Kenneth C Hohmeier, Christina A Spivey, Samantha Boldin, Tara B Moore, Marie Chisholm-Burns
OBJECTIVES: To explore the feasibility and report preliminary outcomes of the integration of a health information exchange (HIE) into community pharmacy workflow clinical service delivery. SETTING: Independent pharmacy in eastern Tennessee. PRACTICE DESCRIPTION: The pharmacy offers medication reconciliation services via HIE access, as well as other clinical pharmacy services. The average number of prescriptions filled weekly is 1900, and staffing included 3...
July 18, 2017: Journal of the American Pharmacists Association: JAPhA
https://www.readbyqxmd.com/read/28732740/exposure-survey-of-trends-in-occupational-practice-expo-s-t-o-p-2015-a-national-survey-of-sharps-injuries-and-mucocutaneous-blood-exposures-among-health-care-workers-in-us-hospitals
#4
T Grimmond, L Good
BACKGROUND: National blood exposure (BE) surveys are valuable to health care facilities striving to reduce percutaneous sharps injuries (SIs) or mucocutaneous (MC) exposures among their health care workers (HCWs). In the Exposure Survey of Trends in Occupational Practice (EXPO-S.T.O.P.) 2015 we surveyed hospital BE incidence among members of the Association of Occupational Health Professionals in Healthcare. METHODS: A 23-item electronic survey requested 2015 data on total SI and MC; SI in nurses, doctors, and surgery; staffed beds; teaching status; full time equivalent staff (FTE), nurse FTE, average daily census (ADC), and adjusted patient days (APD)...
July 18, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28731590/handheld-fetal-doppler-device-for-assessing-heart-rate-in-neonatal-resuscitation
#5
Rinshu Shimabukuro, Kozo Takase, Sachiko Ohde, Isao Kusakawa
BACKGROUND: The use of neonatal 3-lead electrocardiograms (Neo-ECG) is suggested as a method for the assessment of heart rate (HR) in neonatal resuscitation, but primary childbirth facilities (i.e., maternity clinics or maternity homes) are not sufficiently equipped for this. The objective of this study was to confirm the potential of using a handheld fetal Doppler device (FDD), widely used to assess HR in labor room resuscitation, and to compare its equivalency to Neo-ECG. METHODS: In low-risk full-term infants, HR was measured 5 times/minute in minutes 1-5 postpartum using the FDD and Neo-ECG, and their equivalence was compared...
July 21, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/28731555/who-does-nutrition-prevention-work-in-queensland-an-investigation-of-structural-and-political-workforce-reforms
#6
Helen Anna Vidgen, Meg Adam, Danielle Gallegos
AIM: This study aimed (i) to determine the change in the number of government-funded nutrition positions following structural and political reforms and (ii) to describe the remaining workforce available to do nutrition prevention work, including student placements, in Queensland. METHODS: Positions funded by the Queensland government were counted using departmental human resource data and compared with data collected 4 years earlier. Positions not funded by the government were identified using formal professional networks and governance group lists...
February 2017: Nutrition & Dietetics: the Journal of the Dietitians Association of Australia
https://www.readbyqxmd.com/read/28727544/abbreviated-biparametric-prostate-mr-imaging-in-men-with-elevated-prostate-specific-antigen
#7
Christiane K Kuhl, Robin Bruhn, Nils Krämer, Sven Nebelung, Axel Heidenreich, Simone Schrading
Purpose To determine the diagnostic accuracy for clinically significant prostate cancer achieved with abbreviated biparametric prostate magnetic resonance (MR) imaging in comparison with full multiparametric contrast material-enhanced prostate MR imaging in men with elevated prostate-specific antigen (PSA) and negative transrectal ultrasonography (US)-guided biopsy findings; to determine the significant cancer detection rate of biparametric versus full multiparametric contrast-enhanced MR imaging and between-reader agreement for interpretation of biparametric MR imaging...
July 20, 2017: Radiology
https://www.readbyqxmd.com/read/28722685/neural-control-of-finger-movement-via-intracortical-brain-machine-interface
#8
Zachary T Irwin, Karen E Schroeder, Philip P Vu, Autumn J Bullard, Derek M Tat, Chrono S Nu, Alex Vaskov, Samuel R Nason, David E Thompson, Nicole Bentley, Parag G Patil, Cynthia A Chestek
OBJECTIVE: Intracortical brain-machine interfaces (BMIs) are a promising source of prosthesis control signals for individuals with severe motor disabilities. Previous BMI studies have primarily focused on predicting and controlling whole-arm movements; precise control of hand kinematics, however, has not been fully demonstrated. Here, we investigate the continuous decoding of precise finger movements in rhesus macaques. APPROACH: In order to elicit precise and repeatable finger movements, we have developed a novel behavioral task paradigm which requires the subject to acquire virtual fingertip position targets...
July 19, 2017: Journal of Neural Engineering
https://www.readbyqxmd.com/read/28709926/an-efficient-algorithm-for-generating-the-internal-branches-of-a-kingman-coalescent
#9
M Reppell, S Zöllner
Coalescent simulations are a widely used approach for simulating sample genealogies, but can become computationally burdensome in large samples. Methods exist to analytically calculate a sample's expected frequency spectrum without simulating full genealogies. However, statistics that rely on the distribution of the length of internal coalescent branches, such as the probability that two mutations of equal size arose on the same genealogical branch, have previously required full coalescent simulations to estimate...
July 11, 2017: Theoretical Population Biology
https://www.readbyqxmd.com/read/28709096/extensive-green-roof-co2-exchange-and-its-seasonal-variation-quantified-by-eddy-covariance-measurements
#10
Jannik Heusinger, Stephan Weber
The CO2 surface-atmosphere exchange of an unirrigated, extensive green roof in Berlin, Germany was measured by means of the eddy covariance method over a full annual cycle. The present analysis focusses on the cumulative green roof net ecosystem exchange of CO2 (NEE), on its seasonal variation and on green roof physiological characteristics by applying a canopy (A-gs) model. The green roof was a carbon sink with an annual cumulative NEE of -313gCO2m(-2)year(-)(1), equivalent to -85gCm(-2)year(-)(1). Three established CO2 flux gap-filling methods were applied to estimate NEE and to study the performance during different meteorological situations...
July 11, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28705353/the-earnings-payoff-from-attending-a-selective-college
#11
Dirk Witteveen, Paul Attewell
Studies relating the selectivity of colleges to the earnings of their graduates report inconsistent findings. Some find no effects; most report statistically significant but quite small earnings benefits from attending a more selective college; and a few studies report large effects. Analyzing two recent national longitudinal studies of college graduates, with models sensitive to selection bias, we find large earnings payoffs from attending a highly selective college both four and ten years after graduation...
August 2017: Social Science Research
https://www.readbyqxmd.com/read/28701127/changes-in-pathology-test-ordering-by-early-career-general-practitioners-a-longitudinal-study
#12
MULTICENTER STUDY
Parker J Magin, Amanda Tapley, Simon Morgan, Kim Henderson, Elizabeth G Holliday, Andrew R Davey, Jean Ball, Nigel F Catzikiris, Katie J Mulquiney, Mieke L van Driel
OBJECTIVE: To assess the number of pathology tests ordered by general practice registrars during their first 18-24 months of clinical general practice. DESIGN: Longitudinal analysis of ten rounds of data collection (2010-2014) for the Registrar Clinical Encounters in Training (ReCEnT) study, an ongoing, multicentre, cohort study of general practice registrars in Australia. The principal analysis employed negative binomial regression in a generalised estimating equations framework (to account for repeated measures on registrars)...
July 17, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28701117/antibiotics-for-acute-respiratory-infections-in-general-practice-comparison-of-prescribing-rates-with-guideline-recommendations
#13
COMPARATIVE STUDY
Amanda R McCullough, Allan J Pollack, Malene Plejdrup Hansen, Paul P Glasziou, David Fm Looke, Helena C Britt, Christopher B Del Mar
OBJECTIVE: To compare the current rate of antibiotic prescribing for acute respiratory infections (ARIs) in Australian general practice with the recommendations in the most widely consulted therapeutic guidelines in Australia (Therapeutic Guidelines). DESIGN AND SETTING: Comparison of general practice activity data for April 2010 - March 2015 (derived from Bettering the Evaluation and Care of Health [BEACH] study) with estimated rates of prescribing recommended by Therapeutic Guidelines...
July 17, 2017: Medical Journal of Australia
https://www.readbyqxmd.com/read/28699942/hospital-level-factors-associated-with-pediatric-emergency-department-return-visits
#14
Zachary Pittsenbarger, Cary Thurm, Mark Neuman, Sandra Spencer, Harold Simon, Craig Gosdin, Samir Shah, Richard McClead, Anne Stack, Elizabeth Alpern
BACKGROUND: Return visits (RVs) and RVs with admission (RVAs) are commonly used emergency department quality measures. Visit- and patient-level factors, including several social determinants of health, have been associated with RV rates, but hospital-specific factors have not been studied. OBJECTIVE: To identify what hospital-level factors correspond with high RV and RVA rates. SETTING: Multicenter mixed-methods study of hospital characteristics associated with RV and RVA rates...
July 2017: Journal of Hospital Medicine: An Official Publication of the Society of Hospital Medicine
https://www.readbyqxmd.com/read/28694537/survey-of-antimicrobial-stewardship-practices-in-public-hospitals-in-new-zealand-district-health-boards
#15
Sharon J Gardiner, Jane A Pryer, Eamon J Duffy
AIMS: To determine what antimicrobial stewardship (AMS) practices exist in New Zealand public hospitals. METHODS: A quantitative survey based on recommended components of hospital AMS programmes was sent to the 20 DHBs in June 2016. RESULTS: Ten of the 20 DHBs had an AMS committee, nine had dedicated AMS pharmacist full-time equivalents (FTEs) and eight had lead clinician FTEs. Only one DHB met FTE recommendations for AMS pharmacists and two for clinicians (0...
July 7, 2017: New Zealand Medical Journal
https://www.readbyqxmd.com/read/28688785/a-single-dose-of-the-novel-chimeric-subunit-vaccine-e2-cd154-confers-early-full-protection-against-classical-swine-fever-virus
#16
Marisela Suárez, Yusmel Sordo, Yanet Prieto, María P Rodríguez, Lídice Méndez, Elsa M Rodríguez, Alina Rodríguez-Mallon, Elianet Lorenzo, Elaine Santana, Nemecio González, Paula Naranjo, María Teresa Frías, Yamila Carpio, Mario Pablo Estrada
Classical swine fever is an economically important, highly contagious disease of swine worldwide. Subunit vaccines are a suitable alternative for the control of classical swine fever. However, such vaccines have as the main drawback the relatively long period of time required to induce a protective response, which hampers their use under outbreak conditions. In this work, a lentivirus-based gene delivery system is used to obtain a stable recombinant HEK 293 cell line for the expression of E2-CSFV antigen fused to porcine CD154 as immunostimulant molecule...
July 5, 2017: Vaccine
https://www.readbyqxmd.com/read/28687553/development-of-a-pharmacy-resident-rotation-to-expand-decentralized-clinical-pharmacy-services
#17
John D Hill, Jonathan P Williams, Julie F Barnes, Katie M Greenlee, Bcps-Aq Cardiology, Mandy C Leonard
PURPOSE: The development of a pharmacy resident rotation to expand decentralized clinical pharmacy services is described. SUMMARY: In an effort to align with the initiatives proposed within the ASHP Practice Advancement Initiative, the department of pharmacy at Cleveland Clinic, a 1,400-bed academic, tertiary acute care medical center in Cleveland, Ohio, established a goal to provide decentralized clinical pharmacy services for 100% of patient care units within the hospital...
July 15, 2017: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/28676764/bed-rest-and-hypoxic-exposure-affect-sleep-architecture-and-breathing-stability
#18
Shawnda A Morrison, Dani Mirnik, Spela Korsic, Ola Eiken, Igor B Mekjavic, Leja Dolenc-Groselj
Objective: Despite over 50 years of research on the physiological effects of sustained bed rest, data characterizing its effects on sleep macrostructure and breathing stability in humans are scarce. This study was conducted to determine the effects of continuous exposure to hypoxia and sustained best rest, both individually and combined, on nocturnal sleep and breathing stability. Methods: Eleven participants completed three randomized, counter-balanced, 21-days trials of: (1) normoxic bed rest (NBR, PIO2 = 133...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28670710/non-steroidal-anti-inflammatory-drugs-versus-corticosteroids-for-controlling-inflammation-after-uncomplicated-cataract-surgery
#19
REVIEW
Viral V Juthani, Elizabeth Clearfield, Roy S Chuck
BACKGROUND: Cataract is a leading cause of blindness worldwide. Cataract surgery is commonly performed but can result in postoperative inflammation of the eye. Inadequately controlled inflammation increases the risk of complications. Non-steroidal anti-inflammatory drugs (NSAIDs) and corticosteroids are used to prevent and reduce inflammation following cataract surgery, but these two drug classes work by different mechanisms. Corticosteroids are effective, but NSAIDs may provide an additional benefit to reduce inflammation when given in combination with corticosteroids...
July 3, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28659172/what-will-make-a-difference-assessing-the-impact-of-policy-and-non-policy-scenarios-on-estimations-of-the-future-gp-workforce
#20
Caroline O M Laurence, Jonathan Karnon
BACKGROUND: Health workforce planning is based on estimates of future needs for and supply of health care services. Given the pipeline time lag for the training of health professionals, inappropriate workforce planning or policies can lead to extended periods of over- or under-supply of health care providers. Often these policy interventions focus on one determinant of supply and do not incorporate other determinants such as changes in population health which impact the need for services...
June 28, 2017: Human Resources for Health
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