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https://www.readbyqxmd.com/read/29145406/the-axis-il-10-claudin-10-is-implicated-in-the-modulation-of-aggressiveness-of-melanoma-cells-by-b-1-lymphocytes
#1
Elizabeth Cristina Perez, Patricia Xander, Maria Fernanda Lucatelli Laurindo, Ronni Rômulo Novaes E Brito, Bruno Camolese Vivanco, Renato Arruda Mortara, Mario Mariano, José Daniel Lopes, Alexandre Castro Keller
B-1 lymphocytes are known to increase the metastatic potential of B16F10 melanoma cells via the extracellular signal-regulated kinase (ERK) pathway. Since IL-10 is associated with B-1 cells performance, we hypothesized that IL-10 could be implicated in the progression of melanoma. In the present work, we found that the C57BL/6 mice, inoculated with B16F10 cells that were co-cultivated with B-1 lymphocytes from IL-10 knockout mice, developed fewer metastatic nodules than the ones which were injected with the melanoma cells that were cultivated in the presence of wild-type B-1 cells...
2017: PloS One
https://www.readbyqxmd.com/read/29134529/transcriptional-changes-measured-in-rice-roots-after-exposure-to-arsenite-contaminated-sediments
#2
Alexandra Brinke, Georg Reifferscheid, Roland Klein, Ute Feiler, Sebastian Buchinger
Transcriptional analyses are discussed to provide a deeper understanding of the molecular mechanisms underlying toxic effects. Thus, they can complement classic ecotoxicological test methods and potentially allow the identification of biomarkers associated to the exposure of chemical stressors and or adverse biological effects. This feasibility study intended to identify a set of potential gene expression biomarkers for arsenite-exposure in rice roots that could complement the informative value of an existing sediment-contact test with rice...
November 13, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29132974/topical-electrophilic-nitro-fatty-acids-potentiate-cutaneous-inflammation
#3
Alicia R Mathers, Cara D Carey, Meaghan E Killeen, Sonia R Salvatore, Laura K Ferris, Bruce A Freeman, Francisco J Schopfer, Louis D Falo
Endogenous electrophilic fatty acids mediate anti-inflammatory responses by modulating metabolic and inflammatory signal transduction and gene expression. Nitro-fatty acids and other electrophilic fatty acids may thus be useful for the prevention and treatment of immune-mediated diseases, including inflammatory skin disorders. In this regard, subcutaneous (SC) injections of nitro oleic acid (OA-NO2), an exemplary nitro-fatty acid, inhibit skin inflammation in a model of allergic contact dermatitis (ACD). Given the nitration of unsaturated fatty acids during metabolic and inflammatory processes and the growing use of fatty acids in topical formulations, we sought to further study the effect of nitro-fatty acids on cutaneous inflammation...
November 10, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29130485/sophocarpine-attenuates-wear-particle-induced-implant-loosening-by-inhibiting-osteoclastogenesis-and-bone-resorption-via-suppression-of-the-nf-%C3%AE%C2%BAb-signaling-pathway-in-a-rat-model
#4
Chen-He Zhou, Zhong-Li Shi, Jia-Hong Meng, Bin Hu, Chen-Chen Zhao, Yu-Te Yang, Wei Yu, Ze-Xin Chen, Boon Chin Heng, Virginia-Jeni Akila Parkman, Shuai Jiang, Han-Xiao Zhu, Hao-Bo Wu, Wei-Liang Shen, Shi-Gui Yan
BACKGROUND AND PURPOSE: Aseptic prosthesis loosening, caused by wear particles, is one of the most common causes of arthroplasty failure. Extensive and over-activated osteoclast formation and physiological functioning are regarded as the mechanism of prosthesis loosening. Therapeutic modalities based on inhibiting osteoclast formation and bone resorption have been confirmed to be an effective way of preventing aseptic prosthesis loosening. In this study, we have investigated the effects of sophocarpine (SPC, derived from Sophora flavescens) on preventing implant loosening and further explored the underlying mechanisms...
November 11, 2017: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29127261/shortroot-mediated-increase-in-stomatal-density-has-no-impact-on-photosynthetic-efficiency
#5
Mara L Schuler, Olga V Sedelnikova, Berkley J Walker, Peter Westhoff, Jane A Langdale
The co-ordinated positioning of veins, mesophyll cells and stomata across a leaf is crucial for efficient gas exchange and transpiration, and therefore for overall function. In monocot leaves, stomatal cell files are positioned at the flanks of underlying longitudinal leaf veins, rather than directly above or below. This pattern suggests either that stomatal formation is inhibited in epidermal cells directly in contact with the vein, or that specification is induced in cells files beyond the vein. The SHORTROOT pathway specifies distinct cell-types around the vasculature in sub-epidermal layers of both root and shoots, with cell-type identity determined by distance from the vein...
November 10, 2017: Plant Physiology
https://www.readbyqxmd.com/read/29125896/an-in-situ-dynamic-continuum-of-supramolecular-phosphoglycopeptides-enables-formation-of-3d-cell-spheroids
#6
Huaimin Wang, Junfeng Shi, Zhaoqianqi Feng, Rong Zhou, Shiyu Wang, Avital A Rodal, Bing Xu
Higher-order assemblies of proteins, with a structural and dynamic continuum, is a new paradigm in biology, but these insights have yet to be applied in designing biomaterials. Dynamic assemblies of supramolecular phosphoglycopeptides (sPGPs) transform a 2D cell sheet to 3D cell spheroids. A ligand-receptor interaction between a glycopeptide and a phosphopeptide produces sPGPs that form nanoparticles, which transform to nanofibrils upon partially enzymatic dephosphorylation. The assemblies form dynamically and hierarchically in situ on the cell surface, and interact with extracellular matrix molecules and effectively abolish contact inhibition of locomotion (CIL) of the cells...
November 10, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29123981/coculture-of-endothelial-progenitor-cells-and-mesenchymal-stem-cells-enhanced-their-proliferation-and-angiogenesis-through-pdgf-and-notch-signaling
#7
Tangzhao Liang, Lei Zhu, Wenling Gao, Ming Gong, Jianhua Ren, Hui Yao, Kun Wang, Dehai Shi
The beneficial effects of combined use of mesenchymal stem cells (MSCs) and endothelial progenitor cells (EPCs) on tissue repair and regeneration after injury have been demonstrated, but the underlying mechanism remains incompletely understood. This study aimed to investigate the effects of direct contact coculture of human bone marrow-derived EPCs (hEPCs)/human bone marrow-derived MSCs (hMSCs) on their proliferation and angiogenic capacities and the underlying mechanism. hEPCs and hMSCs were cocultured in a 2D mixed monolayer or a 3D transwell membrane cell-to-cell coculture system...
November 2017: FEBS Open Bio
https://www.readbyqxmd.com/read/29122814/non-endoplasmic-reticulum-based-calr-calreticulin-can-coordinate-heterocellular-calcium-signaling-and-vascular-function
#8
Lauren A Biwer, Miranda E Good, Kwangseok Hong, Rahul K Patel, Neha Agrawal, Robin Looft-Wilson, Swapnil K Sonkusare, Brant E Isakson
OBJECTIVE: In resistance arteries, endothelial cell (EC) extensions can make contact with smooth muscle cells, forming myoendothelial junction at holes in the internal elastic lamina (HIEL). At these HIEL, calcium signaling is tightly regulated. Because Calr (calreticulin) can buffer ≈50% of endoplasmic reticulum calcium and is expressed throughout IEL holes in small arteries, the only place where myoendothelial junctions form, we investigated the effect of EC-specific Calr deletion on calcium signaling and vascular function...
November 9, 2017: Arteriosclerosis, Thrombosis, and Vascular Biology
https://www.readbyqxmd.com/read/29118758/combining-v%C3%AE-9v%C3%AE-2-t-cells-with-a-lipophilic-bisphosphonate-efficiently-kills-activated-hepatic-stellate-cells
#9
Xiaoying Zhou, Yanzheng Gu, Hongying Xiao, Ning Kang, Yonghua Xie, Guangbo Zhang, Yan Shi, Xiaoyu Hu, Eric Oldfield, Xueguang Zhang, Yonghui Zhang
Activated hepatic stellate cells (aHSCs) are now established as a central driver of fibrosis in human liver injury. In the presence of chronic or repeated injury, fibrosis, cirrhosis, and hepatocellular carcinoma (HCC) can occur, so there is interest in down-regulating aHSCs activity in order to treat these diseases. Here, we report that Vγ9Vδ2 T cells are reduced in patients with liver cirrhosis, stimulating us to investigate possible interactions between Vγ9Vδ2 T cells and aHSCs. We find that Vγ9Vδ2 T cells kill aHSCs and killing is enhanced when aHSCs are pretreated with BPH-1236, a lipophilic analog of the bone resorption drug zoledronate...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29118372/human-single-chain-transbodies-that-bound-to-domain-i-of-non-structural-protein-5a-ns5a-of-hepatitis-c-virus
#10
Kittirat Glab-Ampai, Monrat Chulanetra, Aijaz Ahmad Malik, Thanate Juntadech, Jeeraphong Thanongsaksrikul, Potjanee Srimanote, Kanyarat Thueng-In, Nitat Sookrung, Pongsri Tongtawe, Wanpen Chaicumpa
A safe and broadly effective direct acting anti-hepatitis C virus (HCV) agent that can withstand the viral mutation is needed. In this study, human single chain antibody variable fragments (HuscFvs) to conserved non-structural protein-5A (NS5A) of HCV were produced by phage display technology. Recombinant NS5A was used as bait for fishing-out the protein bound-phages from the HuscFv-phage display library. NS5A-bound HuscFvs produced by five phage transfected-E. coli clones were linked molecularly to nonaarginine (R9) for making them cell penetrable (become transbodies)...
November 8, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29117458/telephone-based-cbt-and-the-therapeutic-relationship-the-views-and-experiences-of-iapt-practitioners-in-a-low-intensity-service
#11
J Turner, J C Brown, D T Carpenter
INTRODUCTION: Over-the-Telephone (OTT) delivered psychological therapies as an alternative method to face-to-face (F2F) are becoming more prevalent in mental healthcare. Research suggests a range of benefits of OTT use in therapy but there are growing concerns about its consequences for the therapeutic relationship. This paper presents new knowledge regarding psychological practitioners' experience and views of OTT work and its potential effects on the therapeutic relationship in the context of the UK's Increasing Access to Psychological Therapy (IAPT) programme...
November 8, 2017: Journal of Psychiatric and Mental Health Nursing
https://www.readbyqxmd.com/read/29116818/pure-and-oxidized-copper-materials-as-potential-antimicrobial-surfaces-for-spaceflight-activities
#12
C Hahn, M Hans, C Hein, R L Mancinelli, F Mücklich, R Wirth, P Rettberg, C E Hellweg, R Moeller
Microbial biofilms can lead to persistent infections and degrade a variety of materials, and they are notorious for their persistence and resistance to eradication. During long-duration space missions, microbial biofilms present a danger to crew health and spacecraft integrity. The use of antimicrobial surfaces provides an alternative strategy for inhibiting microbial growth and biofilm formation to conventional cleaning procedures and the use of disinfectants. Antimicrobial surfaces contain organic or inorganic compounds, such as antimicrobial peptides or copper and silver, that inhibit microbial growth...
November 8, 2017: Astrobiology
https://www.readbyqxmd.com/read/29115590/overexpression-of-lamin-b1-induces-mitotic-catastrophe-in-colon-cancer-lovo-cells-and-is-associated-with-worse-clinical-outcomes
#13
Magdalena Izdebska, Maciej Gagat, Alina Grzanka
Lamins are the major components of the nuclear lamina and play important roles in many cellular processes. The role of lamins in cancer development and progression is still unclear but it is known that reduced expression of lamin B1 has been observed in colon cancer. Thus, the aim of the present study was to elucidate the influence of LMNB1 upregulation on colon cancer cell line after treatment with 5-FU. The results indicate, that overexpression of LMNB1 induced dose-dependent cell death mainly by mitotic catastrophe pathway...
November 1, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29115308/introducing-multiple-bio-functional-groups-on-the-poly-ether-sulfone-membrane-substrate-to-fabricate-an-effective-antithrombotic-bio-interface
#14
Lingren Wang, Min He, Tao Gong, Xiang Zhang, Lincai Zhang, Tao Liu, Wei Ye, Changjiang Pan, Changsheng Zhao
It has been widely recognized that functional groups on biomaterial surfaces play important roles in blood compatibility. To construct an effective antithrombotic bio-interface onto the poly(ether sulfone) (PES) membrane surface, bio-functional groups of sodium carboxylic (-COONa), sodium sulfonic (-SO3Na) and amino (-NH2) groups were introduced onto the PES membrane surface in three steps: the synthesis of PES with carboxylic (-COOH) groups (CPES) and water-soluble PES with sodium sulfonic (-SO3Na) groups and amino (-NH2) groups (SNPES); the introduction of carboxylic groups onto the PES membrane by blending CPES with PES; and the grafting of SNPES onto CPES/PES membranes via the coupling of amino groups and carboxyl groups...
November 8, 2017: Biomaterials Science
https://www.readbyqxmd.com/read/29114671/synthesis-structure-and-cytotoxicity-of-cyclic-alkyl-amino-carbene-and-acyclic-carbene-complexes-of-group-11-metals
#15
Benoît Bertrand, Alexander S Romanov, Mark Brooks, Josh Davis, Claudia Schmidt, Ingo Ott, Maria O'Connell, Manfred Bochmann
A series of complexes of cyclic (alkyl)(amino)carbene (CAAC) complexes of copper, silver and gold have been investigated for their antiproliferative properties. A second series of acyclic carbene (ACC) complexes of gold(i) were prepared by nucleophilic attack on isocyanide complexes by amines and amino esters, to give (ACC)AuCl, [(ACC)Au(PTA)](+) (PTA = triazaphosphaadamantane), as well as mixed-carbene compounds [(CAAC)Au(ACC)](+). Representative complexes were characterised by X-ray diffraction which confirmed the mononuclear linear structures without close intermolecular contacts or aurophilic interactions...
November 8, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29114051/dscam-mediated-control-of-dendritic-and-axonal-arbor-outgrowth-enforces-tiling-and-inhibits-synaptic-plasticity
#16
Aaron B Simmons, Samuel J Bloomsburg, Joshua M Sukeena, Calvin J Miller, Yohaniz Ortega-Burgos, Bart G Borghuis, Peter G Fuerst
Mature mammalian neurons have a limited ability to extend neurites and make new synaptic connections, but the mechanisms that inhibit such plasticity remain poorly understood. Here, we report that OFF-type retinal bipolar cells in mice are an exception to this rule, as they form new anatomical connections within their tiled dendritic fields well after retinal maturity. The Down syndrome cell-adhesion molecule (Dscam) confines these anatomical rearrangements within the normal tiled fields, as conditional deletion of the gene permits extension of dendrite and axon arbors beyond these borders...
November 7, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29114027/an-alphavirus-e2-membrane-proximal-domain-promotes-envelope-protein-lateral-interactions-and-virus-budding
#17
Emily A Byrd, Margaret Kielian
Alphaviruses are members of a group of small enveloped RNA viruses that includes important human pathogens such as Chikungunya virus and the equine encephalitis viruses. The virus membrane is covered by a lattice composed of 80 spikes, each a trimer of heterodimers of the E2 and E1 transmembrane proteins. During virus endocytic entry, the E1 glycoprotein mediates the low-pH-dependent fusion of the virus membrane with the endosome membrane, thus initiating virus infection. While much is known about E1 structural rearrangements during membrane fusion, it is unclear how the E1/E2 dimer dissociates, a step required for the fusion reaction...
November 7, 2017: MBio
https://www.readbyqxmd.com/read/29113739/structural-insights-into-the-interaction-of-a-monoclonal-antibody-and-nodal-peptides-by-std-nmr-spectroscopy
#18
Luisa Calvanese, Annalia Focà, Annamaria Sandomenico, Giuseppina Focà, Andrea Caporale, Nunzianna Doti, Emanuela Iaccarino, Antonio Leonardi, Gabriella D'Auria, Menotti Ruvo, Lucia Falcigno
Nodal is a growth factor expressed during early embryonic development, but reactivated in several advanced-stage cancers. Targeting of Nodal signaling, which occurs via the binding to Cripto-1 co-receptor, results in inhibition of cell aggressiveness and reduced tumor growth. The Nodal binding region to Cripto-1 was identified and targeted with a high affinity monoclonal antibody (3D1). By STD-NMR technique, we investigated the interaction of Nodal fragments with 3D1 with the aim to elucidate at atomic level the interaction surface...
October 28, 2017: Bioorganic & Medicinal Chemistry
https://www.readbyqxmd.com/read/29113502/osteogenic-and-antibacterial-properties-of-vancomycin-laden-mesoporous-bioglass-plga-composite-scaffolds-for-bone-regeneration-in-infected-bone-defects
#19
Tao Cheng, Haiyun Qu, Guoyou Zhang, Xianlong Zhang
Chronic osteomyelitis and infected bone defects are substantial challenges faced by orthopaedic surgeons. In this study, vancomycin was loaded into mesoporous bioactive glass (MBG) to form a local antibiotic delivery system and then a bone tissue-engineering scaffold combining MBG and poly-(L-lactic-co-glycolic acid) (PLGA) was prepared by freeze-drying fabrication. In vitro degradation and water contact angle analysis suggested that the MBG-incorporated PLGA scaffold exhibited controlled degradability, stabilizing the pH of the surrounding environment and improved the hydrophilicity...
November 7, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29113436/silver-calcium-and-copper-molybdate-compounds-preparation-antibacterial-activity-and-mechanisms
#20
Dajana Tanasic, Adriana Rathner, Jan Philipp Kollender, Petr Rathner, Norbert Müller, Karl Christian Zelenka, Achim Walter Hassel, Cezarina Cela Mardare
Developing novel compounds with antimicrobial properties can be an effective approach to decreasing the number of healthcare-associated infections, particularly in the context of medical devices and touch surfaces. A variety of molybdate powders (Ag2MoO4, CaMoO4, CuMoO4 and Cu3Mo2O9) were synthesized and characterized, and Escherichia coli was used as a model gram-negative bacterium to demonstrate their antimicrobial properties. Optical density measurements, bacterial colony growth, and stained gel images for protein expression clearly showed that silver- and copper molybdates inhibit bacterial growth, whereas CaMoO4 exhibited no bactericidal effect...
November 7, 2017: Biointerphases
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