keyword
MENU ▼
Read by QxMD icon Read
search

contact inhibition

keyword
https://www.readbyqxmd.com/read/29785160/observational-study-of-the-bisphosphonate-related-osteonecrosis-of-jaws
#1
Andreea Elena Lungu, Madalina Anca Lazar, Andrada Tonea, Horatiu Rotaru, Rares Calin Roman, Mindra Eugenia Badea
Introduction: The bisphosphonate-related osteonecrosis of the jaw was first referred to in 2003. Bisphosphonates action is focused on the osteoclasts. The drastic inhibition of the osteoclastic function is harmful for the jaws which are the only bones of the human skeleton in relative contact with the external environment. The adverse effects of the bisphosphonate-related therapy include the pathology for which they are prescribed, the atypical fractures in pathological bone. Method: The aim of this research was to analyze the risk factors and the treatment methods in case of osteonecrosis of the jaws...
2018: Clujul Medical (1957)
https://www.readbyqxmd.com/read/29784856/a-cell-surface-aggregation-promoting-factor-from-lactobacillus-gasseri-contributes-towards-inhibition-of-trichomonas-vaginalis-adhesion-to-human-vaginal-ectocervical-cells
#2
Niha Phukan, Anna E S Brooks, Augusto Simoes-Barbosa
Trichomoniasis, a prevalent sexually transmitted infection, is commonly symptomatic in women. The causative agent is Trichomonas vaginalis , an extracellular protozoan parasite. The host-protective mechanisms and molecules of vaginal lactobacilli that could counteract with this pathogen are largely unknown. This study examines the inhibition promoted by Lactobacillus gasseri against the adhesion of T. vaginalis to host cells, a critical virulence aspect of this pathogen. We observed that the vaginal L. gasseri ATCC 9857 is highly inhibitory by various contact-dependent mechanisms and surface proteins are largely responsible for this inhibitory phenotype...
May 21, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29782512/regulation-of-midgut-cell-proliferation-impacts-aedes-aegypti-susceptibility-to-dengue-virus
#3
Mabel L Taracena, Vanessa Bottino-Rojas, Octavio A C Talyuli, Ana Beatriz Walter-Nuno, José Henrique M Oliveira, Yesseinia I Angleró-Rodriguez, Michael B Wells, George Dimopoulos, Pedro L Oliveira, Gabriela O Paiva-Silva
Aedes aegypti is the vector of some of the most important vector-borne diseases like dengue, chikungunya, zika and yellow fever, affecting millions of people worldwide. The cellular processes that follow a blood meal in the mosquito midgut are directly associated with pathogen transmission. We studied the homeostatic response of the midgut against oxidative stress, as well as bacterial and dengue virus (DENV) infections, focusing on the proliferative ability of the intestinal stem cells (ISC). Inhibition of the peritrophic matrix (PM) formation led to an increase in reactive oxygen species (ROS) production by the epithelial cells in response to contact with the resident microbiota, suggesting that maintenance of low levels of ROS in the intestinal lumen is key to keep ISCs division in balance...
May 21, 2018: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29780928/spontaneous-regression-of-epithelial-downgrowth-from-clear-corneal-phacoemulsification-wound
#4
Ryan M Jaber, Mark Harrod, Jeffrey M Goshe
Purpose: To report a case of spontaneous regression of optical coherence tomography (OCT) and confocal microscopy-supported epithelial downgrowth associated with clear corneal phacoemulsification wound. Observations: A 66-year-old Caucasian male presented two years after phacoemulsification in the left eye with an enlarging cornea endothelial lesion in that eye. His early post-operative course had been complicated by corneal edema and iris transillumination defects...
June 2018: American Journal of Ophthalmology Case Reports
https://www.readbyqxmd.com/read/29780167/e-cadherin-in-contact-inhibition-and-cancer
#5
REVIEW
Alisha M Mendonsa, Tae-Young Na, Barry M Gumbiner
E-cadherin is a key component of the adherens junctions that are integral in cell adhesion and maintaining epithelial phenotype of cells. Homophilic E-cadherin binding between cells is important in mediating contact inhibition of proliferation when cells reach confluence. Loss of E-cadherin expression results in loss of contact inhibition and is associated with increased cell motility and advanced stages of cancer. In this review we discuss the role of E-cadherin and its downstream signaling in regulation of contact inhibition and the development and progression of cancer...
May 21, 2018: Oncogene
https://www.readbyqxmd.com/read/29777765/in-vitro-and-in-vivo-evaluation-of-an-oral-sustained-release-hepatoprotective-caffeine-loaded-w-o-pickering-emulsion-formula-containing-wheat-germ-oil-and-stabilized-by-magnesium-oxide-nanoparticles
#6
Heba Elmotasem, Hala K Farag, Abeer A A Salama
The objective of this study was to innovate an effective oral sustained release hepatoprotective formula for - the water soluble drug - caffeine. Caffeine is rapidly absorbed and eliminated which dictates frequent administration to achieve adequate therapeutic effect. A w/o Pickering emulsion incorporating caffeine in the internal phase was primed. It contained wheat germ oil and was stabilized by synthesized magnesium oxide nanoparticles (MgO NPs). Components selection was based on their antioxidant, hepatoprotective and anticarcinogenic effects...
May 16, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29774031/il-10-producing-b-cells-ability-to-induce-regulatory-t-cells-is-maintained-in-rheumatoid-arthritis
#7
Julie Mielle, Rachel Audo, Michael Hahne, Laurence Macia, Bernard Combe, Jacques Morel, Claire Daien
Despite growing evidence highlighting the relevance of increasing IL-10-producing B cells (B10+ cells) in autoimmune diseases, their functions in patients are still unknown. The aim of this study was to evaluate the functions of CpG-induced B10+ cells isolated from healthy controls (HC) and rheumatoid arthritis (RA) patients, on naïve T cell differentiation. We demonstrated that CpG-induced B10+ cells from HC drove naïve T cell differentiation toward regulatory T cells (Treg cells) and IL-10-producing T cells (Tr1) through IL-10 secretion and cellular contacts...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29772474/mitochondria-rich-cells-adjustments-and-ionic-balance-in-the-neotropical-fish-prochilodus-lineatus-exposed-to-titanium-dioxide-nanoparticles
#8
Talita L L Carmo, Vinícius C Azevedo, Priscila R Siqueira, Tiago D Galvão, Fabrício A Santos, Cláudia B R Martinez, Carlos R Appoloni, Marisa N Fernandes
Manufactured titanium dioxide nanoparticles (TiO2 -NP) have been intensely applied in numerous industrial products and may be a risk for aquatic systems as they are not completely removed from domestic and industrial wastes after water treatment. This study evaluated the osmo- and ionic balance, Na+ /K+ -ATPase, H+ -ATPase and carbonic anhydrase activities and the mitochondria-rich cells (MRC) in the gills and kidney of the Neotropical fish Prochilodus lineatus after 2 (acute) and 14 (subchronic) days of exposure to nominal 0, 1, 5, 10 and 50 mg L-1 TiO2 -NP...
May 9, 2018: Aquatic Toxicology
https://www.readbyqxmd.com/read/29771750/injectable-nonsteroidal-anti-inflammatory-drugs-in-sport
#9
Matthew J Matava
OBJECTIVE: The primary objective of this article is to review the basic science of nonsteroidal anti-inflammatory drugs (NSAIDs), their clinical effects, indications, potential complications, and ethical issues associated with the use of injectable NSAIDs in the treatment of athletes. These objectives are presented taking into consideration the contemporaneous issues associated with the treatment of amateur and professional athletes. DATA SOURCES: A nonformal review of the published medical literature and lay media focusing on the use of injectable NSAIDs in athletes was used for this article...
May 10, 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29767244/propranolol-induces-hemangioma-endothelial-cell-apoptosis-via-a-p53%C3%A2-bax-mediated-pathway
#10
Tian-Hua Yao, Parekejiang Pataer, Krishna Prasad Regmi, Xi-Wen Gu, Quan-Yan Li, Jing-Ting Du, Su-Meng Ge, Jun-Bo Tu
The use of propranolol for the treatment of infantile hemangioma (IH) has been widely investigated in recent years. However, the underlying therapeutic mechanism of propranolol for the treatment of IH remains poorly understood. The aim of the present study was to investigate the expression of proteins regulated by cellular tumor antigen p53 (p53) in associated apoptosis pathways in IH endothelial cells (HemECs) treated with propranolol. Furthermore, the present study aimed to investigate the exact apoptotic pathway underlying the therapeutic effect of propranolol against IH...
May 14, 2018: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29765356/soluble-and-cell-cell-mediated-drivers-of-proteasome-inhibitor-resistance-in-multiple-myeloma
#11
REVIEW
Mariah L Farrell, Michaela R Reagan
It is becoming clear that myeloma cell-induced disruption of the highly organized bone marrow components (both cellular and extracellular) results in destruction of the marrow and support for multiple myeloma (MM) cell proliferation, survival, migration, and drug resistance. Since the first phase I clinical trial on bortezomib was published 15 years ago, proteasome inhibitors (PIs) have become increasingly common for treatment of MM and are currently an essential part of any anti-myeloma combination therapy...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29764728/adaptation-to-phosphate-scarcity-tips-from-arabidopsis-roots
#12
REVIEW
Dolores Gutiérrez-Alanís, Jonathan Odilón Ojeda-Rivera, Lenin Yong-Villalobos, Luis Cárdenas-Torres, Luis Herrera-Estrella
Phosphorus (P) availability is a limiting factor for plant growth and development. Root tip contact with low Pi media triggers diverse changes in the root architecture of Arabidopsis thaliana. The most conspicuous among these modifications is the inhibition of root growth, which is triggered by a shift from an indeterminate to a determinate root growth program. This phenomenon takes place in the root tip and involves a reduction in cell elongation, a decrease in cell proliferation, and the induction of premature cell differentiation, resulting in meristem exhaustion...
May 12, 2018: Trends in Plant Science
https://www.readbyqxmd.com/read/29758540/integrated-antibacterial-and-antifouling-surfaces-via-cross-linking-chitosan-g-eugenol-zwitterionic-copolymer-on-electrospun-membranes
#13
Zhenguang Li, Wenhong Hu, Yunhui Zhao, Lixia Ren, Xiaoyan Yuan
Integrated antibacterial and antifouling surfaces in favor of avoiding implant-related infections are necessarily required for biomaterials when they contact with the body fluid. In this work, an antibacterial and antifouling membrane was developed via cross-linking chitosan-g-eugenol and the zwitterionic copolymer poly(sulfobetaine methylacrylate-co-2-aminoethyl methacrylate) on the electrospun polycarbonate urethane substrate using genipin as a cross-linker. Antibacterial assays demonstrated that the prepared membranes had efficient antibacterial activity with 92...
April 27, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29758107/locking-the-non-template-dna-to-control-transcription
#14
Yuri Nedialkov, Dmitri Svetlov, Georgiy A Belogurov, Irina Artsimovitch
Universally conserved NusG/Spt5 factors reduce RNA polymerase pausing and arrest. In a widely accepted model, these proteins bridge the RNA polymerase clamp and lobe domains across the DNA channel, inhibiting the clamp opening to promote pause-free RNA synthesis. However, recent structures of paused transcription elongation complexes show that the clamp does not open and suggest alternative mechanisms of antipausing. Among these mechanisms, direct contacts of NusG/Spt5 proteins with the nontemplate DNA in the transcription bubble have been proposed to prevent unproductive DNA conformations and thus inhibit arrest...
May 14, 2018: Molecular Microbiology
https://www.readbyqxmd.com/read/29757670/regulatory-t-cell-dynamics-with-abatacept-treatment-in-rheumatoid-arthritis
#15
Kane Langdon, Nagaraja Haleagrahara
The progressive damage in rheumatoid arthritis (RA) has been linked to an increase in inflammatory Th1/Th17 cells and a decrease in number or function of immunomodulatory regulatory T cells (Tregs). Many therapies that are effective in RA are shown to affect Th1/Th17 cells and/or Tregs. One such therapy, abatacept, utilizes a physiologic immunomodulatory molecule called cytotoxic lymphocyte antigen-4 (CTLA-4) which causes contact-dependent inhibition of inflammatory T-cell activation. Recent advances in CTLA-4 research has uncovered the method by which this occurs physiologically but the actions of the CTLA-4Ig fusion protein are still not fully understood...
May 14, 2018: International Reviews of Immunology
https://www.readbyqxmd.com/read/29754900/burst-firing-in-bee-gustatory-neurons-prevents-adaptation
#16
Ashwin Miriyala, Sébastien Kessler, F Claire Rind, Geraldine A Wright
Animals detect changes in the environment using modality-specific, peripheral sensory neurons. The insect gustatory system encodes tastant identity and concentration through the independent firing of gustatory receptor neurons (GRNs) that spike rapidly at stimulus onset and quickly adapt. Here, we show the first evidence that concentrated sugar evokes a temporally structured burst pattern of spiking involving two GRNs within the gustatory sensilla of bumblebees. Bursts of spikes resulted when a sucrose-activated GRN was inhibited by another GRN at a frequency of ∼22 Hz during the first 1 s of stimulation...
May 1, 2018: Current Biology: CB
https://www.readbyqxmd.com/read/29753744/pgc1a-is-required-for-the-induction-of-contact-inhibition-by-suppressing-ros
#17
Seungyeon Yang, Sunsook Hwang, Jiho Jang, Minjoong Kim, Jihye Gwak, Seung Min Jeong
Contact inhibition (CI) is an important tumor-suppressive mechanism that arrests cell cycle when cells reach high density. Indeed, CI is aberrantly absent in cancer cells and the dysregulation of this can contribute to tumorigenesis. Previously, it has been shown that reactive oxygen species (ROS) levels are repressed at high cell density, which is required for CI, but no molecular mechanism of this ROS regulation has been reported. Here, we show that PGC1α regulates cell density-dependent CI. PGC1α is markedly induced in response to high cell density and suppresses ROS production...
May 10, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29752352/functional-analysis-of-hsh155-sf3b1-interactions-with-the-u2-snrna-branch-site-duplex
#18
Tucker Joe Carrocci, Joshua Clark Paulson, Aaron Andrew Hoskins
SF3b1 is an essential component of the U2 snRNP implicated in branch site (BS) recognition and found to be frequently mutated in several human cancers. While recent structures of yeast and human SF3b1 have revealed its molecular architecture, the importance of specific RNA:protein contacts and conformational changes remain largely uncharacterized. Here, we performed mutational analysis of yeast SF3b1, guided by recent structures of the spliceosome. We find that conserved amino acids contacting the U2 snRNA backbone of the U2/BS duplex are nonessential, and that yeast can tolerate truncation of the HEAT repeats containing these amino acids...
May 11, 2018: RNA
https://www.readbyqxmd.com/read/29752124/fabrication-of-hyaluronidase-responsive-biocompatible-multilayers-on-bmp2-loaded-titanium-nanotube-for-the-bacterial-infection-prevention
#19
Linawati Sutrisno, Yan Hu, Xinkun Shen, Menghuan Li, Zhong Luo, Liangliang Dai, Sixiang Wang, Julia Li Zhong, Kaiyong Cai
Infection associated with orthopedic implants is the chief cause of implant failure. An important consideration to prevent the infection at implants is to inhibit the biofilm formation for the initial 6 h. Therefore, we fabricated hyaluronidase-sensitive multilayers of chitosan (Chi)/sodium hyaluronate-lauric acid (SL) onto the surface of bone morphogenetic protein 2 (BMP2) loaded titanium nanotube (TNT) via spin-assisted layer-by-layer technique. The results of both Fourier transform infrared spectroscopy (FTIR) and nuclear magnetic resonance (1 H NMR) confirmed the successful synthesis of SL...
August 1, 2018: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/29749406/improvement-of-the-activity-of-the-anti-hiv-1-integrase-aptamer-t30175-by-introducing-a-modified-thymidine-into-the-loops
#20
Antonella Virgilio, Teresa Amato, Luigi Petraccone, Francesca Esposito, Nicole Grandi, Enzo Tramontano, Raquel Romero, Shozeb Haider, Isabel Gomez-Monterrey, Ettore Novellino, Luciano Mayol, Veronica Esposito, Aldo Galeone
In this paper, we report our investigations on analogues of the anti-human immunodeficiency virus type 1 (HIV-1) integrase (IN) aptamer T30175 in which the individual thymidines forming the loops were replaced by 5-hydroxymethyl-2'-deoxyuridine residues (H). Circular dichroism, nuclear magnetic resonance and gel electrophoresis investigations clearly indicated that all the modified aptamers preserve the ability to form the original 5'-5' end-stacked head-to-head dimeric G-quadruplex structure, in which each G-quadruplex adopts a parallel arrangement and is characterized by three G-tetrads, three propeller loops and one bulge-loop...
May 10, 2018: Scientific Reports
keyword
keyword
90164
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"