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https://www.readbyqxmd.com/read/29126951/circulating-micrornas-as-novel-biomarkers-for-heart-failure
#1
Feng Chen, Jiefu Yang, Yingying Li, Hua Wang
BACKGROUND: The diagnosis of heart failure (HF) remains difficult. A wide variety of studies have indicated that microRNAs play important roles in the pathophysiology of HF. HYPOTHESIS: Circulating miRNAs may be the potential biomarkers for HF. METHODS: In this study, a genome-wide plasma miRNA expression analysis was performed in thirteen HF patients and three controls. Microarray was used for the initial screen, followed by validation with quantitative real-time PCR (qRT-PCR) assays in an independent cohort of thirty-three HF patients and twenty controls...
November 7, 2017: Hellenic Journal of Cardiology: HJC, Hellēnikē Kardiologikē Epitheōrēsē
https://www.readbyqxmd.com/read/29117535/rescuing-infusion-of-mirna-1-prevents-cardiac-remodeling-in-a-heart-selective-mirna-deficient-mouse
#2
Shuilian Luo, Yuhang Chen, Rui He, Yujun Shi, Li Su
OBJECTIVE: The decreased expression of muscle-specific microRNA-1 (miR-1) has been found in many cardiovascular diseases and is considered to contribute to heart failure (HF). Here we investigated the role of miR-1 in myocardium protection by infusion of miR-1 in a cardiac global miRNA-deficient mouse. METHODS: We generated a cardiac-selective miRNA-deficient mouse by crossing Dicer(flox/flox) mice with mice expressing tamoxifen-inducible Cre recombinase under the control of a mouse αMHC promoter...
November 5, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29116107/micrornas-regulating-superoxide-dismutase-2-are-new-circulating-biomarkers-of-heart-failure
#3
Emilie Dubois-Deruy, Marie Cuvelliez, Jan Fiedler, Henri Charrier, Paul Mulder, Eleonore Hebbar, Angelika Pfanne, Olivia Beseme, Maggy Chwastyniak, Philippe Amouyel, Vincent Richard, Christophe Bauters, Thomas Thum, Florence Pinet
Although several risk factors such as infarct size have been identified, the progression of heart failure (HF) remains difficult to predict in clinical practice. Using an experimental rat model of post-myocardial infarction (MI), we previously identified 45 proteins differentially modulated during HF by proteomic analysis. This study sought to identify microRNAs (miRNAs) able to regulate these proteins and to test their relevance as biomarkers for HF. In silico bioinformatical analysis selected 13 miRNAs related to the 45 proteins previously identified...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29101298/loss-of-microrna-22-prevents-high-fat-diet-induced-dyslipidemia-and-increases-energy-expenditure-without-affecting-cardiac-hypertrophy
#4
Gabriela Placoná Diniz, Zhan-Peng Huang, Jianming Liu, Jinghai Chen, Jian Ding, Renata Inzinna Fonseca, Maria Luiza Barreto-Chaves, Jose Donato, Xiaoyun Hu, Da-Zhi Wang
Obesity is associated with development of diverse diseases, including cardiovascular diseases and dyslipidemia. MiRNA-22 (miR-22) is a critical regulator of cardiac function and targets genes involved in metabolic processes. Previously we generated miR-22 null mice and we showed that loss of miR-22 blunted cardiac hypertrophy induced by mechanohormornal stress. In this study, we examined the role of miR-22 in the cardiac and metabolic alterations promoted by high fat (HF) diet. We found that loss of miR-22 attenuated the gain of fat mass and prevented dyslipidemia induced by HF diet, although the body weight gain, or glucose intolerance and insulin resistance did not seem to be affected...
November 3, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/29027324/circulating-microrna-132-levels-improve-risk-prediction-for-heart-failure-hospitalization-in-patients-with-chronic-heart-failure
#5
Serge Masson, Sandor Batkai, Julia Beermann, Christian Bär, Angelika Pfanne, Sabrina Thum, Michela Magnoli, Giovanna Balconi, Gian Luigi Nicolosi, Luigi Tavazzi, Roberto Latini, Thomas Thum
AIMS: Non-coding microRNAs (miRNAs) are critically involved in cardiovascular pathophysiology. Since they are measurable in most body fluids, they have been proposed as circulating biomarkers. We examined the prognostic value of a specific candidate miRNA in a large cohort of patients with chronic heart failure (HF) enrolled in a multicentre clinical trial. METHODS AND RESULTS: Plasma levels of miR-132 were measured using miRNA-specific PCR-based technologies at randomization in 953 patients with chronic, symptomatic HF from the GISSI-Heart Failure trial...
October 12, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/29020916/integrated-analysis-of-coding-genes-and-non-coding-rnas-during-hair-follicle-cycle-of-cashmere-goat-capra-hircus
#6
Shanhe Wang, Wei Ge, Zhixin Luo, Yang Guo, Beilei Jiao, Lei Qu, Zhiying Zhang, Xin Wang
BACKGROUND: Cashmere growth is a seasonal and cyclic phenomenon under the control of photoperiod and multiple stimulatory and inhibitory signals. Beyond relevant coding genes, microRNA (miRNA) and long non coding RNA (lncRNA) play an indispensable role in hair follicle (HF) development and skin homeostasis. Furthermore, the influence of lncRNA upon miRNA function is also rapidly emerging. However, little is known about miRNAs, lncRNAs and their functions as well as their interactions on cashmere development and cycling...
October 11, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28949058/prognostic-value-of-circulating-micrornas-on-heart-failure-related-morbidity-and-mortality-in-two-large-diverse-cohorts-of-general-heart-failure-patients
#7
Antoni Bayes-Genis, David E Lanfear, Maurice W J de Ronde, Josep Lupón, Joost J Leenders, Zhen Liu, Nicolaas P A Zuithoff, Marinus J C Eijkemans, Elisabet Zamora, Marta De Antonio, Aeilko H Zwinderman, Sara-Joan Pinto-Sietsma, Yigal M Pinto
AIMS: Small studies suggested circulating microRNAs (miRNAs) as biomarkers for heart failure (HF). However, standardized approaches and quality assessment for measuring circulating miRNAs are not uniformly established, and most studies have been small, so that results are inconsistent. We used a standardized data handling protocol, optimized for circulating miRNA qPCRs to remove noise and used it to assess which circulating miRNAs robustly add prognostic information in patients with HF...
September 26, 2017: European Journal of Heart Failure
https://www.readbyqxmd.com/read/28811555/identification-of-novel-micrornas-in-the-sheep-heart-and-their-regulation-in-heart-failure
#8
Lee Lee Wong, Miriam T Rademaker, Eng Leng Saw, Kar Sheng Lew, Leigh J Ellmers, Christopher J Charles, Arthur Mark Richards, Peipei Wang
Study of microRNA (miRNAs) using sheep models is limited due to lack of miRNA information. We therefore investigated oar-miRNAs and their regulation in an ovine model of heart failure (HF). Left ventricular (LV) tissue was collected from normal (Cont), HF (LV pacing @ ~220bpm for 13-days) and HF-recovery sheep (HF-R, 26-days after pacing cessation). MiRNA expression was profiled using next-generation sequencing (NGS) and miRNA array, and validated by stem-loop qPCR. Detected sequences were mapped against the ovine genome (Oar v4...
August 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28770611/clinical-significance-of-mirna-autophagy-transcript-expression-in-patients-with-hepatocellular-carcinoma
#9
Marwa Matboli, Ayman E Shafei, Hanan H Shehata, Nesreen Nabil, Nourhan Hossam, Ahmed Em Azazy, Ahmed Hf El-Tawdi, Omar Abdel-Rahman
AIM: This study integrates autophagy transcripts miRNAs expression based on bioinformatic analysis followed by clinical validation. METHODOLOGY: Cellular jun proto-oncogene mRNA, LAMP2 mRNA, miR-16 and miR-146a level were investigated in the serum and tissue of patients with hepatocellular carcinoma (HCC), chronic hepatitis C and healthy volunteers by quantitative real-time PCR. The prognostic power of this serum RNA panel was explored. RESULTS: The expression of serum cellular jun proto-oncogene mRNA, LAMP2 mRNA, miR-16 and miR-146a were positive in 85...
August 3, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28765595/integration-of-mirna-and-mrna-expression-profiles-reveals-microrna-regulated-networks-during-muscle-wasting-in-cardiac-cachexia
#10
Leonardo N Moraes, Geysson J Fernandez, Ivan J Vechetti-Júnior, Paula P Freire, Rodrigo W A Souza, Rolando A R Villacis, Silvia R Rogatto, Patricia P Reis, Maeli Dal-Pai-Silva, Robson F Carvalho
Cardiac cachexia (CC) is a common complication of heart failure (HF) associated with muscle wasting and poor patient prognosis. Although different mechanisms have been proposed to explain muscle wasting during CC, its pathogenesis is still not understood. Here, we described an integrative analysis between miRNA and mRNA expression profiles of muscle wasting during CC. Global gene expression profiling identified 1,281 genes and 19 miRNAs differentially expressed in muscle wasting during CC. Several of these deregulated genes are known or putative targets of the altered miRNAs, including miR-29a-3p, miR-29b-3p, miR-210-5p, miR-214, and miR-489...
August 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28693530/analysis-of-circulating-micrornas-in-patients-with-repaired-tetralogy-of-fallot-with-and-without-heart-failure
#11
Masood Abu-Halima, Eckart Meese, Andreas Keller, Hashim Abdul-Khaliq, Tanja Rädle-Hurst
BACKGROUND: MicroRNAs (miRNAs) are a class of regulatory RNAs that regulate gene expression post-transcriptionally. Little, however, is known on the expression profile of circulating miRNAs in Tetralogy of Fallot (TOF) patients late after surgical repair. In this study, we aimed to identify the specific patterns of circulating miRNAs in blood of patients with repaired, non-syndromic TOF and to assess whether these specific miRNAs may be useful to differentiate patients with and without heart failure...
July 10, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28466998/cardiac-remodelling-and-preeclampsia-an-overview-of-overlapping-circulating-mirnas
#12
Zenab Mohseni, Marc E A Spaanderman, Jolien Oben, Martina Calore, Elianne Derksen, Salwan Al-Nasiry, Leon de Windt, Chahinda Ghossein-Doha
OBJECTIVES: Preeclampsia (PE) is strongly associated with heart failure (HF) later in life. During preeclamptic pregnancy the left ventricle (LV) remodels in a concentric way. This aberrant remodelling often persists after delivery. The concentric remodelling during PE can induce molecular signatures that may explain the associated increased risk of HF. This signature may be evaluated in terms of microRNAs (miRNAs). This review evaluates existing literature on miRNA expression data in concentric remodelling on the one hand and PE on the other to generate a list of overlapping miRNA expression patterns in both...
May 3, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28437675/whole-blood-sequencing-reveals-circulating-microrna-associations-with-high-risk-traits-in-non-st-segment-elevation-acute-coronary-syndrome
#13
Alice Wang, Lydia Coulter Kwee, Elizabeth Grass, Megan L Neely, Simon G Gregory, Keith A A Fox, Paul W Armstrong, Harvey D White, E Magnus Ohman, Matthew T Roe, Svati H Shah, Mark Y Chan
BACKGROUND AND AIMS: Although circulating microRNA (miRNAs) have emerged as biomarkers predicting mortality in acute coronary syndrome (ACS), more data are needed to understand these mechanisms. Mapping miRNAs to high-risk traits may identify miRNAs involved in pathways conferring risk for poor outcome in ACS. We aim to investigate the relationship between circulating miRNAs and high-risk traits in non-ST-segment elevation acute coronary syndrome (NSTE-ACS). METHODS: Whole-genome miRNA sequencing was performed on RNA extracted from whole blood of 199 patients with NSTE-ACS...
March 30, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28319523/plasma-levels-of-microrna-155-are-upregulated-with-long-term-left-ventricular-assist-device-support
#14
Teresa Wang, Emily C O'Brien, Joseph G Rogers, Daniel L Jacoby, Michael E Chen, Jeffrey M Testani, Dawn E Bowles, Carmelo A Milano, G Michael Felker, Chetan B Patel, Pramod N Bonde, Tariq Ahmad
Left ventricular assist device (LVAD) therapy unloads the failing heart but exposes the human body to unique pathophysiologic demands such as continuous blood flow and complete univentricular support, which are associated with increased risk of adverse clinical outcomes. MicroRNAs (miRNAs) are 22-23 nucleotide RNAs involved in regulation of multiple biologic processes including the pathogenesis of heart failure (HF). Thus, measurement of miRNAs may have potential in both diagnostics as circulating biomarkers and in therapeutics for targeted interventions...
September 2017: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://www.readbyqxmd.com/read/28292573/-use-of-micrornas-in-heart-failure-management
#15
Luis Alejandro Arias Sosa
Heart failure (HF) is a high impact disease that affects all human populations, demanding the development of new strategies and methods to manage this pathology. That's why microRNAs, small noncoding RNAs that regulate gene expression, appear as an important option in the diagnosis, prognosis and treatment of this disease. MiRNAs seems to have a future on HF handling, because can be isolated from body fluids such as blood, and changes in its levels can be associated with the presence, stage and specific disease features, which makes them an interesting option as biomarkers...
July 2017: Archivos de Cardiología de México
https://www.readbyqxmd.com/read/28228108/expression-profiling-and-bioinformatic-analyses-suggest-new-target-genes-and-pathways-for-human-hair-follicle-related-micrornas
#16
Lara M Hochfeld, Thomas Anhalt, Céline S Reinbold, Marisol Herrera-Rivero, Nadine Fricker, Markus M Nöthen, Stefanie Heilmann-Heimbach
BACKGROUND: Human hair follicle (HF) cycling is characterised by the tight orchestration and regulation of signalling cascades. Research shows that micro(mi)RNAs are potent regulators of these pathways. However, knowledge of the expression of miRNAs and their target genes and pathways in the human HF is limited. The objective of this study was to improve understanding of the role of miRNAs and their regulatory interactions in the human HF. METHODS: Expression levels of ten candidate miRNAs with reported functions in hair biology were assessed in HFs from 25 healthy male donors...
February 22, 2017: BMC Dermatology
https://www.readbyqxmd.com/read/28055298/vitamin-d-limits-inflammation-linked-microrna-expression-in-adipocytes-in-vitro-and-in-vivo-a-new-mechanism-for-the-regulation-of-inflammation-by-vitamin-d
#17
Esma Karkeni, Lauriane Bonnet, Julie Marcotorchino, Franck Tourniaire, Julien Astier, Jianping Ye, Jean-François Landrier
Inflammation of adipose tissue is believed to be a contributing factor to many chronic diseases associated with obesity. Vitamin D (VD) is now known to limit this metabolic inflammation by decreasing inflammatory marker expression and leukocyte infiltration in adipose tissue. In this study, we investigated the impact of VD on microRNA (miR) expression in inflammatory conditions in human and mouse adipocytes, using high-throughput methodology (miRNA PCR arrays). Firstly, we identified three miRs (miR-146a, miR-150, and miR-155) positively regulated by TNFα in human adipocytes...
January 5, 2017: Epigenetics: Official Journal of the DNA Methylation Society
https://www.readbyqxmd.com/read/28040802/dysregulated-long-intergenic-non-coding-rna-modules-contribute-to-heart-failure
#18
Lin Pang, Jing Hu, Guanxiong Zhang, Xiang Li, Xinxin Zhang, Fulong Yu, Yujia Lan, Jinyuan Xu, Bo Pang, Dong Han, Yun Xiao, Xia Li
Long intergenic non-coding RNAs (lincRNAs) are emerging as important regulatory molecules involved in diseases including heart failure. However, little is known about how the lincRNAs work together with protein-coding genes (PCGs) contributing to the pathogenesis of heart failure. In this study, we constructed a comprehensive transcriptome profile of lincRNAs, PCGs and miRNAs using RNA-seq and miRNA-seq data of 16 heart failure patients (HFs) and 8 non-failing individuals (NFs). Through integrating lincRNA and PCG expression profiles, we identified HF-associated lincRNA modules...
September 13, 2016: Oncotarget
https://www.readbyqxmd.com/read/28008641/effects-of-mirnas-on-myocardial-apoptosis-by-modulating-mitochondria-related-proteins
#19
REVIEW
Yanfang Zhao, Murugavel Ponnusamy, Yanhan Dong, Lei Zhang, Kun Wang, Peifeng Li
Myocardial apoptosis play a vital role in pathogenesis of cardiovascular diseases. The intrinsic pathway of apoptosis (mitochondrial apoptosis pathway) and abnormal mitochondrial fission and fusion have a detrimental effect on cells under a variety of intracellular stresses including hypoxia, oxidative stress, drug toxicity or DNA damage and contributes to the development of heart failure (HF), myocardial infarction (MI), diabetic cardiomyopathy and ischaemia/reperfusion injury (I/R). MicroRNAs (miRNAs) are endogenous short non-coding RNAs, which target 3'-untranslated region of mRNA to switch off gene expression...
April 2017: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/27914211/micrornas-in-cardiovascular-disease-clinical-application
#20
REVIEW
Christian Schulte, Mahir Karakas, Tanja Zeller
microRNAs (miRNAs) are well-known, powerful regulators of gene expression, and their potential to serve as circulating biomarkers is widely accepted. In cardiovascular disease (CVD), numerous studies have suggested miRNAs as strong circulating biomarkers with high diagnostic as well as prognostic power. In coronary artery disease (CAD) and heart failure (HF), miRNAs have been suggested as reliable biomarkers matching up to established protein-based such as cardiac troponins (cT) or natriuretic peptides. Also, in other CVD entities, miRNAs were identified as surprisingly specific biomarkers - with great potential for clinical applicability, especially in those entities that lack specific protein-based biomarkers such as atrial fibrillation (AF) and acute pulmonary embolism (APE)...
May 1, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
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