Mahesh Mundalil Vasu, Linda Koshy, Sanjay Ganapathi, Panniyammakal Jeemon, Madhusoodanan Urulangodi, Srinivas Gopala, Philip Greeva, Ayyappan Anitha, Salim Reethu, Prasad Divya, Shajahan Shamla, Kumar Sumitha, Madhuma Madhavan, C Purushothaman Vineeth, Rajamoni Kochumoni, Sivadasanpillai Harikrishnan
MicroRNAs (miRNAs), a class of non-coding RNAs, are utilized as biomarkers for a wide range of disorders. Circulating miRNAs are proposed as potential markers in the clinical identification of heart failure (HF). However, identifying miRNA biomarkers in HF requires identification of robust endogenous control miRNAs for normalization in differential expression analysis. Hence, this study aimed to identify circulating miRNAs that can be utilized as endogenous controls in HF. We evaluated the expression of eight miRNAs, which were previously reported as endogenous controls in different pathological conditions...
January 27, 2024: International Journal of Biological Macromolecules