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Transitional urology

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https://www.readbyqxmd.com/read/28269753/lncrna-neat1-is-a-prognosis-biomarker-and-regulates-cancer-progression-via-epithelial-mesenchymal-transition-in-clear-cell-renal-cell-carcinoma
#1
Li Ning, Zhiguo Li, Dianjun Wei, Haiyan Chen, Chao Yang
BACKGROUND: The long non-coding RNAs (lncRNAs) are emerging as important regulators in cancer progression. Clear cell renal cell carcinoma (ccRCC) is one of the most common urological cancers with poor prognosis. In this study, we examined the functional role of the lncRNA, nuclear enriched abundant transcript 1 (NEAT1) in ccRCC progression. METHODS: We performed quantitative real time PCR and western blotting assays to measure mRNA and protein expression levels, respectively...
February 27, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28265329/the-transition-process-of-spina-bifida-patients-to-adult-centred-care-an-assessment-of-the-canadian-urology-landscape
#2
REVIEW
Amy Wajchendler, Peter Anderson, Martin A Koyle
INTRODUCTION: Due to medical advances over the past three decades, the vast majority of children with spina bifida (SB) now survive into adulthood. As a result, there is a need to implement a well-defined urological transition process for these patients from the pediatric to adult environment. The objective of this study was to identify and analyze the current medical practices employed and the attitudes regarding transition by Canadian pediatric urologists caring for the SB population...
January 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/28258630/everolimus-suppresses-invasion-and-migration-of-renal-cell-carcinoma-by-inhibiting-fak-activity-and-reversing-epithelial-to-mesenchymal-transition-in-vitro-and-in-vivo
#3
Sheng-Wen Wu, Pei-Ni Chen, Chin-Yin Lin, Yih-Shou Hsieh, Horng-Rong Chang
Renal cell carcinoma (RCC) is the most common type of kidney cancer in adults and the major cause of mortality in urological cancer. Most patients with RCC are asymptomatic until the disease is advanced and unresectable. In this situation, systemic therapy with immunotherapy or molecularly targeted therapy agents play an important role in therapeutic strategy. Everolimus (EVE), an m-TOR inhibitor, has the potential to inhibit tumor progression at multiple levels and is indicated for the treatment of advanced RCC in patients whose disease has metastasis...
March 4, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/28251485/endoscopic-treatment-of-upper-tract-urothelial-carcinoma
#4
REVIEW
Daniel P Verges, Costas D Lallas, Scott G Hubosky, Demetrius H Bagley
PURPOSE OF REVIEW: This study aims to make the reader be aware of recent trends regarding the endoscopic management of upper tract urothelial carcinoma (UTUC) via review of the urologic literature over the past 5 years. Given the rare incidence of this disease, and the lack of level 1 evidence, systematic reviews and meta-analyses were also evaluated. Studies of importance are also considered and outlined in the annotated reference section. RECENT FINDINGS: The PubMed database was queried using the following medical subject headings (MeSH terms): "carcinoma, transitional cell," "ureter," "ureteral neoplasms," "kidney pelvis," "endoscopy," "laser therapy," "ureteroscopy," "urologic surgical procedures," and "ureteroscopes...
April 2017: Current Urology Reports
https://www.readbyqxmd.com/read/28216943/non-transitional-cell-carcinoma-of-the-upper-urinary-tract-a-case-series-among-305-cases-at-a-tertiary-urology-institute
#5
Mohamed Mohamed Elawdy, Diaa-Eldin Taha, Yasser Osman, Mohamed Abd El-Hamid, Mohsen El-Mekresh
Non-transitional cell carcinomas (non-TCC) of the upper urinary tract as squamous cell carcinoma (SCC), adenocarcinoma, and small cell carcinoma (SmCC) are rare with few case reports in the literature. We retrospectively reviewed our patients who surgically treated for upper tract urothelial carcinoma from 1983 to 2013 for non-TCC pathological cancer characteristics and survival. Among 305 patients, only 5 (1.6%) cases were found: One case of SmCC, another had adenocarcinoma, and 3 SCC cases. None of them had intravesical recurrence and the cancer-specific survival for non-TCC cohort is markedly decreased (log-rank = 0...
January 2017: Urology Annals
https://www.readbyqxmd.com/read/28163084/research-needs-for-effective-transition-in-lifelong-care-of-congenital-genitourinary-conditions-a-workshop-sponsored-by-the-national-institute-of-diabetes-and-digestive-and-kidney-diseases
#6
REVIEW
Michael H Hsieh, Hadley M Wood, Brad E Dicianno, Nienke P Dosa, Veronica Gomez-Lobo, Tej K Mattoo, Rosalia Misseri, Jenna M Norton, Kathleen J Sawin, Peter Scal, James E Wright, Robert A Star, Tamara Bavendam
Over the last 5 decades, health-care advances have yielded quantum improvements in the life expectancy of individuals with congenital genitourinary conditions (CGCs), leading to a crisis of care. Many individuals with CGC enter adulthood unprepared to manage their condition. Pediatric CGC specialists lack training to manage adulthood-related health-care issues, whereas adult genitourinary specialists lack training within the context of CGCs. To address these challenges, the National Institutes of Diabetes and Digestive and Kidney Diseases convened individuals with CGCs and experts from a variety of fields to identify research needs to improve transitional urology care...
February 2, 2017: Urology
https://www.readbyqxmd.com/read/28093163/re-adolescent-urology-and-transitional-care
#7
Alan J Wein
No abstract text is available yet for this article.
February 2017: Journal of Urology
https://www.readbyqxmd.com/read/28004432/role-of-coagulation-factors-in-urological-malignancy-a-prospective-controlled-study-on-prostate-renal-and-bladder-cancer
#8
Aristeidis Alevizopoulos, Stavros Tyritzis, Ioannis Leotsakos, Ioanna Anastasopoulou, Christos Pournaras, Paraskevi Kotsis, Olga Katsarou, Christos Alamanis, Konstantinos Stravodimos, Constantinos Constantinides
OBJECTIVES: To study the behavior of specific coagulation factors in different types of non-metastatic urological cancers, and to identify their possible role as diagnostic and prognostic markers. METHODS: This was a prospective controlled study, which included three cancer patient groups and a control group of healthy individuals. The cancer subgroups consisted of renal (n = 44), prostate (n = 56) and bladder cancer (n = 47). We excluded patients receiving anticoagulant therapy, or with significant comorbidity...
February 2017: International Journal of Urology: Official Journal of the Japanese Urological Association
https://www.readbyqxmd.com/read/27986531/patient-function-and-the-value-of-surgical-care-for-kidney-cancer
#9
Hung-Jui Tan, Joseph D Shirk, Karim Chamie, Mark S Litwin, Jim C Hu
PURPOSE: Frailty and functional status have emerged as significant predictors of morbidity and mortality for patients undergoing cancer surgery. To articulate the impact on value (ie quality per cost), we compared perioperative outcomes and expenditures according to patient function for older adults undergoing kidney cancer surgery. MATERIALS AND METHODS: Using linked SEER (Surveillance, Epidemiology and End Results)-Medicare data, we identified 19,129 elderly patients with kidney cancer treated with nonablative surgery from 2000 to 2009...
December 13, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27979598/how-successful-is-the-transition-to-adult-urology-care-in-spina-bifida-a-single-center-7-year-experience
#10
Konrad M Szymanski, Mark P Cain, Thomas J Hardacker, Rosalia Misseri
INTRODUCTION: Rates of successful transition from adolescent to adult spina bifida (SB) care are unknown. OBJECTIVE: We aimed to assess rates and predictors of successful transition from a multidisciplinary SB clinic to a transitional urology clinic (TUC), or a pediatric or adult urologist. STUDY DESIGN: We retrospectively reviewed patients discharged from a multidisciplinary SB clinic (2006-2012), collecting demographic and clinical data...
February 2017: Journal of Pediatric Urology
https://www.readbyqxmd.com/read/27926518/higher-programmed-cell-death-1-ligand-1-pd-l1-mrna-level-in-clear-cell-renal-cell-carcinomas-is-associated-with-a-favorable-outcome-due-to-the-active-immune-responses-in-tumor-tissues
#11
Xiang-Hui Ning, Yan-Qing Gong, Shi-Ming He, Teng Li, Jiang-Yi Wang, Shuang-He Peng, Jin-Chao Chen, Jia-Yuan Liu, Nie-Nie Qi, Ying-Lu Guo, Kan Gong
Renal cell carcinoma is one of the most common urological tumors. The role of programmed cell death 1 ligand 1 (PD-L1) in renal cell carcinomas in predicting outcome of the patients is yet unclear. We analyzed the clinical and RNA-seq data of 522 kidney clear cell cancer, 259 kidney papillary cell carcinoma and 66 kidney chromophobe patients from The Cancer Genome Atlas (TCGA) database. In kidney clear cell cancer patients with high PD-L1 mRNA level and low PD-L1 mRNA level in tumors, the median overall survival periods were 45...
January 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/27800063/a-proposed-solution-to-a-urological-tightrope-walk-the-challenge-of-transition-of-spina-bifida-patients-from-pediatric-to-adult-care-in-ontario
#12
REVIEW
Martin A Koyle, Nicole Golda, Christopher Hillis, Betty Oldershaw, Margaret DeMelo, Jennifer Uyeno
No abstract text is available yet for this article.
September 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27800049/comparing-transition-of-care-from-adolescence-to-adulthood-for-patients-with-congenital-urological-conditions-in-canada-and-the-u-s
#13
Rosalia Misseri
No abstract text is available yet for this article.
September 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27800048/a-proposed-solution-to-a-urological-tightrope-walk-the-challenge-of-transition-of-spina-bifida-patients-from-pediatric-to-adult-care-in-ontario
#14
REVIEW
Martin A Koyle, Nicole Golda, Christopher Hillis, Betty Oldershaw, Margaret DeMelo, Jennifer Uyeno
No abstract text is available yet for this article.
September 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27800045/advocating-for-transition-of-care-in-urology
#15
EDITORIAL
D Robert Siemens
No abstract text is available yet for this article.
September 2016: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/27749363/leading-contributors-to-success-of-transitional-urology-units
#16
Dan Wood
PURPOSE OF REVIEW: There is increasing recognition of the need for life-long care in patients who have congenital urological anomalies. This study looks at the factors surrounding transition and suggests those, which may improve the success. RECENT FINDINGS: One of the most challenging phases in this care is adolescence. There are the physical and psychological changes that all adolescents go through. Patients need medical surveillance through this time in order to ensure good care and patient safety...
January 2017: Current Opinion in Urology
https://www.readbyqxmd.com/read/27672439/zinner-s-syndrome-report-of-two-cases-and-review-of-the-literature
#17
Amine Slaoui, Souhail Regragui, Abdelouahad Lasri, Tarik Karmouni, Khalid El Khader, Abdellatif Koutani, Ahmed Ibn Attya
BACKGROUND: Congenital malformations of the seminal vesicle are uncommon, and most of them are cystic malformations. If an insult occurs between the 4th and the 13 h gestational week, the embryogenesis of the kidney, ureter, seminal vesicle, and vas deferens could be altered. Cysts of the seminal vesicle may appear with a mass effect, dysuria, epididymitis, or obstruction of the gastrointestinal and genitourinary tracts. Approximately two thirds of them are associated with ipsilateral renal agenesis, because both the ureteral buds and seminal vesicles originate from the mesonephric (Wolffian) duct...
2016: Basic and Clinical Andrology
https://www.readbyqxmd.com/read/27665407/-urologic-malignancies-in-renal-transplant-candidates-and-recipients
#18
F Kleinclauss, R Thuret, T Murez, M O Timsit
OBJECTIVE: To review epidemiology and management of urologic neoplasms in renal transplant candidates and recipients. MATERIAL AND METHODS: Relevant publications were identified through Medline (http://www.ncbi.nlm.nih.gov) and Embase (http://www.embase.com) database using the following keywords, alone or in association, "neoplasms"; "prostate cancer"; "renal carcinoma"; "renal transplantation"; "transitional carcinoma"; "waiting list". Articles were selected according to methods, language of publication and relevance...
November 2016: Progrès en Urologie
https://www.readbyqxmd.com/read/27588140/il-8-induces-the-epithelial-mesenchymal-transition-of-renal-cell-carcinoma-cells-through-the-activation-of-akt-signaling
#19
Nan Zhou, Fuding Lu, Cheng Liu, Kewei Xu, Jian Huang, Dexin Yu, Liangkuan Bi
The epithelial-mesenchymal transition (EMT) process has increasingly been examined due to its role in the progression of human tumors. Renal cell carcinoma (RCC) is one of the most common urological tumors that results in patient mortality. Previous studies have demonstrated that the EMT process is closely associated with the metastasis of RCC; however, the underlying molecular mechanism has not been determined yet. The present study revealed that interleukin (IL)-8 was highly expressed in metastatic RCC. IL-8 could induce the EMT of an RCC cell line by enhancing N-cadherin expression and decreasing E-cadherin expression...
September 2016: Oncology Letters
https://www.readbyqxmd.com/read/27576024/exposure-to-and-attitudes-regarding-transgender-education-among-urology-residents
#20
Geolani W Dy, Nathan C Osbun, Shane D Morrison, David W Grant, Paul A Merguerian
INTRODUCTION: Transgender individuals are underserved within the health care system but might increasingly seek urologic care as insurers expand coverage for medical and surgical gender transition. AIM: To evaluate urology residents' exposure to transgender patient care and their perceived importance of transgender surgical education. METHODS: Urology residents from a representative sample of U.S. training programs were asked to complete a cross-sectional survey from January through March 2016...
October 2016: Journal of Sexual Medicine
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