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https://www.readbyqxmd.com/read/29454300/gold-copper-bimetallic-nanoparticles-supported-on-nano-p-zeolite-modified-carbon-paste-electrode-as-an-efficient-electrocatalyst-and-sensitive-sensor-for-determination-of-hydrazine
#1
Fatemeh Amiripour, Seyed Naser Azizi, Shahram Ghasemi
In this report, a facile, efficient and low cost electrochemical sensor based on bimetallic Au-Cu nanoparticles supported on P nanozeolite modified carbon paste electrode (Au-Cu/NPZ/CPE) was constructed and its efficiency for determination of hydrazine in trace level was studied. For this purpose, agro waste material, stem sweep ash (SSA) was employed as the starting material (silica source) for the synthesis of nano P zeolite (NPZ). After characterization of the synthesized NPZ by analytical instruments (scanning electronic microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD) and Fourier transform infrared (FT-IR) spectroscopy), construction of Au-Cu/NPZ/CPE was performed by three steps procedure involving preparation of nano P zeolite modified carbon paste electrode (NPZ/CPE), introducing Cu +2 ions into nano zeolite structure by ion exchange and electrochemical reduction of Cu +2 ions upon applying constant potential...
February 5, 2018: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29454281/probing-the-%C3%AE-pocket-of-the-active-site-of-human-liver-glycogen-phosphorylase-with-3-c-%C3%AE-d-glucopyranosyl-5-4-substituted-phenyl-1-2-4-triazole-inhibitors
#2
Efthimios Kyriakis, Theodora G A Solovou, Sándor Kun, Katalin Czifrák, Béla Szőcs, László Juhász, Éva Bokor, George A Stravodimos, Anastassia L Kantsadi, Demetra S M Chatzileontiadou, Vassiliki T Skamnaki, László Somsák, Demetres D Leonidas
Human liver glycogen phosphorylase (hlGP), a key enzyme in glycogen metabolism, is a valid pharmaceutical target for the development of new anti-hyperglycaemic agents for type 2 diabetes. Inhibitor discovery studies have focused on the active site and in particular on glucopyranose based compounds with a β-1 substituent long enough to exploit interactions with a cavity adjacent to the active site, termed the β-pocket. Recently, C-β-d-glucopyranosyl imidazoles and 1, 2, 4-triazoles proved to be the best known glucose derived inhibitors of hlGP...
February 12, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29454247/tolerance-and-growth-kinetics-of-bacteria-isolated-from-gold-and-gemstone-mining-sites-in-response-to-heavy-metal-concentrations
#3
Oluwatosin Gbemisola Oladipo, Obinna Tobechukwu Ezeokoli, Mark Steve Maboeta, Jacobus Johannes Bezuidenhout, Louwrens R Tiedt, Anine Jordaan, Cornelius Carlos Bezuidenhout
Response and growth kinetics of microbes in contaminated medium are useful indices for the screening and selection of tolerant species for eco-friendly bio-augmentative remediation of polluted environments. In this study, the heavy metal (HM) tolerance, bioaccumulation and growth kinetics of seven bacterial strains isolated from mining sites to 10 HMs (Cd, Hg, Ni, Al, Cr, Pb, Cu, Fe, Mn and Zn) at varied concentrations (25-600 mgL -1 ) were investigated. The isolates were phylogenetically (16S rRNA gene) related to Lysinibacillus macroides, Achromobacter spanius, Bacillus kochii, B...
February 14, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29454167/polydopamine-coated-nanocomposites-of-angelica-gigas-nakai-extract-and-their-therapeutic-potential-for-triple-negative-breast-cancer-cells
#4
Suyeong Nam, Song Yi Lee, Jung-Jin Kim, Wie-Soo Kang, In-Soo Yoon, Hyun-Jong Cho
Polydopamine (PD)-coated nanocomposites (NCs) based on the ethanol extract of Angelica gigas Nakai (AGN EtOH ext) were fabricated and evaluated for breast cancer therapy. AGN NCs were prepared using a modified emulsification-solvent evaporation method and were further incubated in dopamine solution (at pH 8.6) to be covered with the PD layer. PD-AGN NCs with a 213-nm mean diameter, narrow size distribution, and negative zeta potential values were fabricated in this study. Less negative (close to zero) zeta potential value of PD-AGN NCs than that of AGN NCs implied the existence of the PD layer in the outer surface of NCs...
February 11, 2018: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29454028/fabricating-3d-printed-orally-disintegrating-printlets-using-selective-laser-sintering
#5
Fabrizio Fina, Christine M Madla, Alvaro Goyanes, Jiaxin Zhang, Simon Gaisford, Abdul W Basit
Selective laser sintering (SLS) is a three-dimensional printing (3DP) technology employed to manufacture plastic, metallic or ceramic objects. The aim of this study was to demonstrate the feasibility of SLS to fabricating novel solid dosage forms with accelerated drug release properties, and with a view to create orally disintegrating formulations. Two polymers (hydroxypropyl methylcellulose (HPMC E5) and vinylpyrrolidone-vinyl acetate copolymer (Kollidon ® VA 64)) were separately mixed with 5% paracetamol (used as a model drug) and 3% Candurin ® gold sheen colorant; the powder mixes were subjected to SLS printing resulting in the manufacture of printlets (3DP tablets)...
February 14, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29454022/five-new-schinortriterpenoids-from-schisandra-propinqua-var-propinqua
#6
Wen-Ping Ding, Kun Hu, Miao Liu, Xing-Ren Li, Rong Chen, Xiao-Nian Li, Xue Du, Pema-Tenzin Puno, Han-Dong Sun
Five new schinortriterpenoids, propinqtrilactones A and B (1 and 2) with rare lancischiartane scaffold, and propindilactones V-X (3-5), were isolated from the stems and leaves of Schisandra propinqua var. propinqua. Their structures were elucidated on the basis of comprehensive spectroscopic and mass spectrometric analysis. The absolute configurations of 1-5 were determined by CD methods, X-ray diffraction analysis and theoretical calculations. 4 was tested for its cytotoxic activities against five human tumor cell lines...
February 14, 2018: Fitoterapia
https://www.readbyqxmd.com/read/29453904/synthesis-self-assembly-and-photoresponsive-liquid-crystals-based-on-azobenzene-derivatives
#7
Hongyan Wang, Yi Han, Wei Yuan, Mengjiao Wu, Yulan Chen
A new class of rod-coil-rod molecules with an azobenzene core were synthesized. They were found to form robust organogels in several kinds of organic solvents. Scanning electron microscopy (SEM), transmission electron microscopy (TEM), atomic force microscopy (AFM), FT-IR spectroscopy, UV-vis absorption spectroscopy, 1H NMR, and X-ray diffraction (XRD) revealed that in these organogels, the molecules self-assembled into nanofiber network with an H-type aggregation mode under the joint effect of Pi-Pi stacking, intermolecular hydrogen bonding, and van der Waals forces...
February 17, 2018: Chemistry, An Asian Journal
https://www.readbyqxmd.com/read/29453852/a-sulfonozanamivir-analogue-has-potent-anti-influenza-virus-activity
#8
Ádám Hadházi, Linghui Li, Benjamin Bailly, Andrea Maggioni, Gael Martin, Larissa Dirr, Jeffrey Dyason, Robin Thomson, George Gao, Anikó Borbás, Thomas Ve, Mauro Pascolutti, Mark von Itzstein
Influenza virus infection continues to cause significant, often severe, respiratory illness worldwide. A validated target for development of anti-influenza agents is the viral surface protein sialidase. In the current study, we have discovered a highly potent inhibitor of influenza virus sialidase, based on a novel sialosyl sulfonate template. The synthesised 3-guanidino sialosyl α-sulfonate, a sulfonozanamivir analogue, inhibits virus replication in vitro at a nanomolar level, comparable to that of anti-influenza drug zanamivir...
February 17, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29453846/fabrication-of-miniature-elastomer-lenses-with-programmable-liquid-mold-for-smartphone-microscopy-curing-polydimethylsiloxane-with-in-situ-curvature-control
#9
Bhuvaneshwari Karunakaran, Joseph Tharion, Arvind Ramrao Dhawangale, Debjani Paul, Soumyo Mukherji
Miniature lenses can transform commercial imaging systems, e.g., smartphones and webcams, into powerful, low-cost, handheld microscopes. To date, the reproducible fabrication of polymer lenses is still a challenge as they require controlled dispensing of viscous liquid. This paper reports a reproducible lens fabrication technique using liquid mold with programmable curvature and off-the-shelf materials. The lens curvature is controlled during fabrication by tuning the curvature of an interface of two immiscible liquids [polydimethylsiloxane (PDMS) and glycerol]...
February 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29453714/backbone-1-h-13-c-and-15-n-assignments-of-the-extracellular-region-of-human-fc%C3%AE-receptor-iiib
#10
Rina Yogo, Saeko Yanaka, Koichi Kato
Fcγ receptor (FcγR) promotes various immune responses through interactions with the Fc portion of immunoglobulin G (IgG). FcγRIIIb is a glycosylphosphatidylinositol-linked protein expressed on neutrophils and triggers degranulation and opsonic phagocytosis. The extracellular region of FcγR is composed of two Ig-fold domains and can be cleaved as a soluble form (sFcγRIIIb), which is also reactive with complement receptor type 3. Although structure and Fc interaction of sFcγRIIIb have been characterized by X-ray crystallography, little has been known about its structure in solution...
February 16, 2018: Biomolecular NMR Assignments
https://www.readbyqxmd.com/read/29453685/transcatheter-closure-of-arterial-duct-in-infants-6-kg-amplatzer-duct-occluder-type-i-vs-amplatzer-duct-occluder-ii-additional-sizes
#11
Giuseppe Santoro, Mario Giordano, Gianpiero Gaio, Maria Teresa Palladino, Giovanbattista Capozzi, Carola Iacono, Maria Giovanna Russo
Transcatheter closure of arterial duct (AD) remains challenging in low-weight patients and using Amplatzer Duct Occluder devices is still considered off-label in infants < 6 kg. This study aimed to report a large, single-center experience of percutaneous AD closure in infants < 6 kg as well as to compare the most frequently used devices, Amplatzer Duct Occluder type I (ADO I) and Amplatzer Duct Occluder type II Additional Sizes devices (ADO II-AS) (St. Jude Medical Corp, St. Paul, MN, USA). From March 2000 to March 2017, among the 762 patients submitted to percutaneous closure of AD at our Institution, 33 were infants < 6 kg (age 4...
February 17, 2018: Pediatric Cardiology
https://www.readbyqxmd.com/read/29453592/patient-specific-registration-of-3d-ct-angiography-cta-with-x-ray-fluoroscopy-for-image-fusion-during-transcatheter-aortic-valve-implantation-tavi-increases-performance-of-the-procedure
#12
I Vernikouskaya, W Rottbauer, J Seeger, B Gonska, V Rasche, Jochen Wöhrle
OBJECTIVES: The aim of this study was to adapt patient-specifically a co-registration procedure for image fusion (IF) of a pre-interventional CT dataset with real-time X-ray (XR) fluoroscopy during transfemoral transcatheter aortic valve implantation (TAVI), enabling improved performance of the procedure. BACKGROUND: The ability to use 3D models of the respective anatomies to complement the anatomic information obtained by XR fluoroscopy and provide a greater degree of real-time anatomical guidance holds great potential for complex cardiac interventions, especially for TAVI procedures with cerebral protection...
February 16, 2018: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/29453586/three-dimensional-orientation-and-location-dependent-varying-rules-of-radiographic-angles-of-the-acetabular-cup
#13
Jing-Xin Zhao, Xiu-Yun Su, Zhe Zhao, Ruo-Xiu Xiao, Li-Cheng Zhang, Pei-Fu Tang
AIM: The aim of this study is to demonstrate the varying rules of radiographic angles following varying three-dimensional (3D) orientations and locations of cup using an accurate mathematical model. METHODS: A cone model is established to address the quantitative relationship between the opening circle of cup and its ellipse projection on radiograph. The varying rules of two-dimensional (2D) radiographic anteversion (RA) and inclination (RI) angles can be analyzed...
February 17, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29453462/gq-11-a-new-ppar-agonist-improves-obesity-induced-metabolic-alterations-in-ldlr-mice
#14
Jacqueline C Silva, Edson M de Oliveira, Walter M Turato, Gustavo H G Trossini, Vinícius G Maltarollo, Marina G R Pitta, Ivan R Pitta, Beatriz de Las Heras, Lisardo Boscá, Martina Rudnicki, Dulcineia S P Abdalla
BACKGROUND: Obesity and insulin resistance/diabetes are important risk factors for cardiovascular diseases and demand safe and efficacious therapeutics. OBJECTIVE: To assess the effects of a new thiazolidine compound-GQ-11-on obesity and insulin resistance induced by a diabetogenic diet in LDL receptor-deficient (LDLr -/- ) mice. METHODS: Molecular docking simulations of GQ-11, PPARα and PPARγ structures were performed. Male C57BL/6J LDLr -/- mice fed a diabetogenic diet for 24 weeks were treated with vehicle, GQ-11 or pioglitazone or (20 mg/kg/day) for 28 days by oral gavage...
January 30, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29453391/diffusion-mechanism-in-the-sodium-ion-battery-material-sodium-cobaltate
#15
T J Willis, D G Porter, D J Voneshen, S Uthayakumar, F Demmel, M J Gutmann, M Roger, K Refson, J P Goff
High performance batteries based on the movement of Li ions in Li x CoO 2 have made possible a revolution in mobile electronic technology, from laptops to mobile phones. However, the scarcity of Li and the demand for energy storage for renewables has led to intense interest in Na-ion batteries, including structurally-related Na x CoO 2 . Here we have determined the diffusion mechanism for Na 0.8 CoO 2 using diffuse x-ray scattering, quasi-elastic neutron scattering and ab-initio molecular dynamics simulations, and we find that the sodium ordering provides diffusion pathways and governs the diffusion rate...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29453358/georeferenced-soil-provenancing-with-digital-signatures
#16
M Tighe, N Forster, C Guppy, D Savage, P Grave, I M Young
The provenance or origin of a soil sample is of interest in soil forensics, archaeology, and biosecurity. In all of these fields, highly specialized and often expensive analysis is usually combined with expert interpretation to estimate sample origin. In this proof of concept study we apply rapid and non-destructive spectral analysis to the question of direct soil provenancing. This approach is based on one of the underlying tenets of soil science - that soil pedogenesis is spatially unique, and thus digital spectral signatures of soil can be related directly, rather than via individual soil properties, to a georeferenced location...
February 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29453141/dft-td-dft-calculations-spectroscopic-characterizations-ftir-nmr-uv-vis-molecular-docking-and-enzyme-inhibition-study-of-7-benzoyloxycoumarin
#17
Mahboob Alam, Mohammad Jane Alam, Shaista Azaz, Mehtab Parveen, Soonheum Park, Shabbir Ahmad
The quantum chemical study, spectroscopic characterization and biological activity of the pharmaceutically active 7-benzoyloxycoumarin (2) molecule have been presented. Potential energy surface (PES) scanning has been performed to search for the most stable molecular geometry of the present compound. The stable geometry in the ground state, IR, UV-Vis absorption and NMR ( 13 C, 1 H) spectra of the title compound were theoretically obtained and compared with the experimental one. Various theoretical molecular parameters like molecular energy, atomic charges, dipole moment, thermodynamic parameters, donor-acceptor natural bond orbital (NBO) hyperconjugative interaction energies, frontier molecular orbitals energies, HOMO-LUMO gap, molecular electrostatic potential, chemical reactivity descriptors, molecular polarizability and non-linear optical (NLO) properties are presented...
February 8, 2018: Computational Biology and Chemistry
https://www.readbyqxmd.com/read/29453122/assessment-of-the-potential-hazard-represented-by-natural-raw-materials-containing-mineral-fibres-the-case-of-the-feldspar-from-orani-sardinia-italy
#18
Alessandro F Gualtieri, Nicola Bursi Gandolfi, Simone Pollastri, Roberta Rinaldi, Orietta Sala, Giovanni Martinelli, Tiziana Bacci, Federica Paoli, Alberto Viani, Ruggero Vigliaturo
This work describes the nature of the potentially hazardous fibrous amphibole found in the Orani's feldspar mine (Sardinia, Italy). To identify its nature, a protocol of analysis including morphometric, chemical and crystallographic characterizations was applied. Thanks to this approach, it was possible to classify the observed fibres as tremolite after comparing chemical data, SEM/TEM observations, FTIR/ Raman spectra and X-ray diffraction data with those reported for a standard sample. The unit cell parameters of the investigated tremolite phase are a = 9...
February 7, 2018: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/29453094/a-multidisciplinary-study-of-3-%C3%AE-d-glucopyranosyl-5-substituted-1-2-4-triazole-derivatives-as-glycogen-phosphorylase-inhibitors-computation-synthesis-crystallography-and-kinetics-reveal-new-potent-inhibitors
#19
Sándor Kun, Jaida Begum, Efthimios Kyriakis, Evgenia C V Stamati, Thomas A Barkas, Eszter Szennyes, Éva Bokor, Katalin E Szabó, George A Stravodimos, Ádám Sipos, Tibor Docsa, Pál Gergely, Colin Moffatt, Myrto S Patraskaki, Maria C Kokolaki, Alkistis Gkerdi, Vassiliki T Skamnaki, Demetres D Leonidas, László Somsák, Joseph M Hayes
3-(β-d-Glucopyranosyl)-5-substituted-1,2,4-triazoles have been revealed as an effective scaffold for the development of potent glycogen phosphorylase (GP) inhibitors but with the potency very sensitive to the nature of the alkyl/aryl 5-substituent (Kun et al., Eur. J. Med. Chem. 2014, 76, 567). For a training set of these ligands, quantum mechanics-polarized ligand docking (QM-PLD) demonstrated good potential to identify larger differences in potencies (predictive index PI = 0.82) and potent inhibitors with K i 's < 10 μM (AU-ROC = 0...
February 2, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29453080/improvement-of-the-radiographic-method-for-measurement-of-effective-energy-of-pulsed-x-ray-emission-from-a-pf-device-for-different-anode-s-insert-materials
#20
Seyed Milad Miremad, Babak Shirani
In this paper, effective energy of pulsed X-Ray emitted from a Mather-type plasma focus device in stored energy of 2.5 kJ with six different anode's insert materials was measured using radiographic method with attenuation filters. Since intensity and energy of X-ray beam were considerably changed with changing the insert material, the method was improved by using different filters simultaneously in all the experiments and selection of the best filter in each experiment according to the appropriate criteria...
February 9, 2018: Applied Radiation and Isotopes
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