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https://www.readbyqxmd.com/read/28107745/femtomolar-detection-of-cardiac-troponin-i-using-a-novel-label-free-and-reagent-free-dendrimer-enhanced-impedimetric-immunosensor
#1
Rashida Akter, Bongjin Jeong, Yong-Mi Lee, Jong-Soon Choi, Md Aminur Rahman
A novel highly sensitive dendrimer coupled impedimetric immunosensor was developed for the label-free and reagent-free detection of cardiac troponin I (TnI) in serum samples. The immunosensor probe was fabricated by covalently attaching carboxylic acid-functionalized third generation (G3) poly (amidoamine) (PAMAM) dendrimer (Den) on the 3, 3', 5, 5'-tetramethyl benzidine (TMB) modified 6-mercaptohexanoic acid (MHA) self-assembled monolayer (SAM) on a gold (Au) electrode. Monoclonal anti-TnI antibody was then covalently immobilized on the Den and TMB attached MHA SAM modified surface...
January 12, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28107736/crystal-structures-binding-interactions-and-adme-evaluation-of-brain-penetrant-n-substituted-indazole-5-carboxamides-as-subnanomolar-selective-monoamine-oxidase-b-and-dual-mao-a-b-inhibitors
#2
Nikolay T Tzvetkov, Hans-Georg Stammler, Beate Neumann, Silvia Hristova, Liudmil Antonov, Marcus Gastreich
The pharmacological and physicochemical analysis of structurally optimized N-alkyl-substituted indazole-5-carboxamides, developed as potential drug and radioligand candidates for the treatment and diagnosis of Parkinson's disease (PD) and other neurological disorders, is reported. Recent efforts have been focused on the development of subnanomolar potent, selective MAO-B (N1-alkyl-substituted compounds 12a-14a and 15) and dual active MAO-A/B (N2-methylated compounds 12b-14b) inhibitors with nanomolar potency towards MAO-B and moderately active against MAO-A enzyme, respectively...
January 11, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28107711/the-influence-of-dissolved-si-on-ni-precipitate-formation-at-the-kaolinite-water-interface-kinetics-drs-and-exafs-analysis
#3
Xiaoli Tan, Ge Liu, Huiyang Mei, Ming Fang, Xuemei Ren, Changlun Chen
Unraveling the formation process of Ni precipitates at molecular scale is important for understanding the fate and mobility of Ni species in the real environment. Dissolved Si presents in the natural environment ubiquitously, which can alter Ni sorption as well as incorporation into neoformed precipitates. Batch experiments show that the dissolved Si leads to a rapid increase in the Ni sorption rate and interferes with the formation of Ni precipitates. The results of diffuse reflectance spectroscopy (DRS) and extended X-ray absorption fine structure (EXAFS) spectroscopy analyses suggest that the nucleation of a (Ni,Al) phyllosilicate phase involves a kaolinite-like local structure...
January 16, 2017: Chemosphere
https://www.readbyqxmd.com/read/28107705/incorporation-of-antimicrobial-peptides-in-nanostructured-lipid-membrane-mimetic-bilayer-cubosomes
#4
Thomas G Meikle, Alexandru Zabara, Lynne J Waddington, Frances Separovic, Calum J Drummond, Charlotte E Conn
The inverse bicontinuous lipidic cubic phase offers a simple and robust membrane mimetic with the ability to encapsulate peptides, potentially increasing bioavailability, while also offering a platform from which functionalized, targeted nanoparticles can be developed. Herein we have investigated the use of a number of cubic phase nanoparticle systems with encapsulated antimicrobial peptides gramicidin A', melittin, and alamethicin. The optimal peptide loading ranges, over which cubic symmetry was retained, were determined using small angle X-ray scattering...
January 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28107618/carbon-hollow-microspheres-with-a-designable-mesoporous-shell-for-high-performance-electromagnetic-wave-absorption
#5
Hailong Xu, Xiaowei Yin, Meng Zhu, Meikang Han, Zexin Hou, Xinliang Li, Litong Zhang, Laifei Cheng
In this work, mesoporous carbon hollow microspheres (PCHMs) with designable mesoporous shell and interior void are constructed by a facile in situ stöber templating approach and a pyrolysis-etching process. The PCHMs are characterized by scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectra, Raman, nitrogen adsorption and desorption system. A uniform mesoporous shell (pore size 4.7 nm) with a thickness of 55 nm and a cavity size of 345 nm is realized. The composite of paraffin mixed with 20 wt...
January 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28107616/superhydrophilic-antireflective-periodic-mesoporous-organosilica-coating-on-flexible-polyimide-substrate-with-strong-abrasion-resistance
#6
Jing Wang, Cong Zhang, Chunming Yang, Ce Zhang, Mengchao Wang, Jing Zhang, Yao Xu
Superhydrophilic antireflective periodic mesoporous organosilica (PMO) coating was prepared on flexible polyimide substrate via solvent-evaporation-induced self-assembly (SEISA) method, in which tetraethoxysilane (TEOS) and a special bridged silsesquioxane were used as reactants. The bridged silsesquioxane, EG-BSQ, was synthesized through the stoichiometric reaction between 3-glycidoxyporpyltrimethoxysilane (GPTMS) and ethylene diamine (EDA) at 60 (○)C with no catalyst. Under the influence of surfactant, TEOS and EG-BSQ co-condensed and enclosed the ordered mesporous in the coating...
January 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28107510/effect-of-the-crystal-environment-on-side-chain-conformational-dynamics-in-cyanovirin-n-investigated-through-crystal-and-solution-molecular-dynamics-simulations
#7
Logan S Ahlstrom, Ivan I Vorontsov, Jun Shi, Osamu Miyashita
Side chains in protein crystal structures are essential for understanding biochemical processes such as catalysis and molecular recognition. However, crystal packing could influence side-chain conformation and dynamics, thus complicating functional interpretations of available experimental structures. Here we investigate the effect of crystal packing on side-chain conformational dynamics with crystal and solution molecular dynamics simulations using Cyanovirin-N as a model system. Side-chain ensembles for solvent-exposed residues obtained from simulation largely reflect the conformations observed in the X-ray structure...
2017: PloS One
https://www.readbyqxmd.com/read/28107468/micro-x-ray-computed-tomography-mass-loss-assessment-of-different-uhmwpe-a-hip-joint-simulator-study-on-standard-vs-cross-linked-polyethylene
#8
Saverio Affatato, Filippo Zanini, Simone Carmignato
More than 60.000 hip arthroplasty are performed every year in Italy. Although Ultra-High-Molecular-Weight-Polyethylene remains the most used material as acetabular cup, wear of this material induces over time in vivo a foreign-body response and consequently osteolysis, pain, and the need of implant revision. Furthermore, oxidative wear of the polyethylene provoke several and severe failures. To solve these problems, highly cross-linked polyethylene and Vitamin-E-stabilized polyethylene were introduced in the last years...
2017: PloS One
https://www.readbyqxmd.com/read/28107348/predicting-length-of-stay-among-patients-discharged-from-the-emergency-department-using-an-accelerated-failure-time-model
#9
Chung-Hsien Chaou, Hsiu-Hsi Chen, Shu-Hui Chang, Petrus Tang, Shin-Liang Pan, Amy Ming-Fang Yen, Te-Fa Chiu
BACKGROUND: Emergency department (ED) crowding continues to be an important health care issue in modern countries. Among the many crucial quality indicators for monitoring the throughput process, a patient's length of stay (LOS) is considered the most important one since it is both the cause and the result of ED crowding. The aim of this study is to identify and quantify the influence of different patient-related or diagnostic activities-related factors on the ED LOS of discharged patients...
2017: PloS One
https://www.readbyqxmd.com/read/28107038/prevalence-of-and-factors-associated-with-sarcopenia-in-korean-cancer-survivors-based-on-data-obtained-by-the-korea-national-health-and-nutrition-examination-survey-knhanes-2008-2011
#10
Eun Young Kim, Kirang Kim, Young Saing Kim, Hee Kyung Ahn, Yu Mi Jeong, Jeong Ho Kim, Won-Jun Choi
Using a representative dataset from the Korea National Health and Nutrition Examination Survey (KNHANES) from 2008 to 2011, we analyzed anthropometric and dual-energy X-ray absorptiometry (DXA)-determined body composition findings for 493 cancer survivors (mean age a61.1 ± 12.6 years; 35.7% male). A much higher proportion of men (30.1%) than women (0.6%) met the criteria of sarcopenia. Subjects with a history of lung cancer, genitourinary cancer, or gastric cancer were prone to develop sarcopenia (31.6%, 26...
January 20, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28107035/determination-of-the-zinc-concentration-in-human-fingernails-using-laser-induced-breakdown-spectroscopy
#11
Vlora A Riberdy, Christopher J Frederickson, Steven J Rehse
The absolute concentration of Zn in human fingernail clippings was determined ex vivo using 1064 nm laser-induced breakdown spectroscopy and confirmed by speciated isotope dilution mass spectrometry. A nail testing protocol that sampled across the nail (perpendicular to the direction of growth) was developed and validated by scanning electron microscopy energy-dispersive X-ray spectrometry. Using this protocol, a partial least squares (PLS) regression model predicted the Zn concentration in the fingernails of five people to within an average of 7 ppm...
January 1, 2017: Applied Spectroscopy
https://www.readbyqxmd.com/read/28107018/structure-wettability-and-thermal-stability-of-organic-thin-films-on-gold-generated-from-the-molecular-self-assembly-of-unsymmetrical-oligo-ethylene-glycol-spiroalkanedithiols
#12
Pawilai Chinwangso, Han Ju Lee, Andrew C Jamison, Maria D Marquez, Chul Soon Park, T Randall Lee
Organic thin-films on gold were prepared from a set of new, custom-designed bidentate alkanethiols possessing a mixture of normal alkane and methoxy-terminated tri(ethyleneglycol) chains. The new unsymmetrical spiroalkanedithiol adsorbates were of the form [CH3O(CH2CH2O)3(CH2)5]-[CH3(CH2)n+1]C[CH2SH]2 where n = 3 and 14; designated EG3C7-C7 and EG3C7-C18, respectively. Their corresponding self-assembled monolayers (SAMs) on gold were characterized and compared with monothiol SAMs derived from an analogous normal alkanethiol (C18SH) and an alkanethiol terminated with an oligo(ethylene glycol) (OEG) moiety (i...
January 20, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28106997/time-and-nanoparticle-concentration-affect-the-extractability-of-cu-from-cuo-np-amended-soil
#13
Xiaoyu Gao, Eleanor Spielman-Sun, Sónia Morais Rodrigues, Elizabeth A Casman, Gregory V Lowry
We assess the effect of CuO nanoparticle (NP) concentration and soil aging time on the extractability of Cu from a standard sandy soil (Lufa 2.1). The soil was dosed with CuO NP or Cu(NO3)2 at 10 mg Cu kg-1 soil (mg/kg) or 100 mg/kg total copper, then extracted using either 0.01M CaCl2 or 0.005M DTPA (pH 7.6) extraction fluids at selected times over 31 days. For 100 mg/kg CuO NP, the amount of DTPA-extractable Cu in soil increased from 3 wt% immediately after mixing to 38 wt% after 31 days. In contrast, the extractability of Cu(NO3)2 was highest initially, decreasing with time...
January 20, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28106988/factors-governing-the-performance-of-bauxite-for-fluoride-remediation-of-groundwater
#14
Aruna Kirani Katyayani Cherukumilli, Caroline Delaire, Susan E Amrose, Ashok J Gadgil
Globally, 200 million people drink groundwater contaminated with fluoride concentrations exceeding the World Health Organization's recommended level (WHO-MCL =1.5 mg F-/L). This study investigates the use of minimally-processed (dried/milled) bauxite ore as an inexpensive adsorbent for remediating fluoride-contaminated groundwater in resource-constrained areas. Adsorption experiments in synthetic groundwater using bauxites from Guinea, Ghana, USA, and India as single-use batch dispersive media demonstrated that doses of ~10-23 g/L could effectively remediate 10 mg F-/L...
January 20, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28106933/carbatriphyrin-3-1-1-displays-distinct-coordination-approach-of-biii-to-generate-organoborane-and-weak-c-h%C3%A2-b-interactions
#15
Alagar Srinivasan, B Adinarayana, Ajesh P Thomas, Prerna Yadav, Vanga Mukundam
The carbatriphyrin(3.1.1) is the structural isomer of biphenylcorrole and achieved by switching the bonding mode of biphenyl unit from 3,3' to 2,3' which turns the corrole into triphyrin analogue. The presence of m-arene unit in the framework restricts the overall conjugation, thus leads to non-aromatic macrocycle. The protonation experiments afford trifluoroacetate ion complex. The coordination chemistry reveals that the bottom approach of boron(III) ion forms weak C-H...B interactions, however top approach stabilizes the organoborane complex and the product distribution relies on the basicity of the proton scavengers...
January 20, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28106856/green-synthesis-and-characterization-of-palladium-nanoparticles-using-origanum-vulgare-l-extract-and-their-catalytic-activity
#16
Mohammed Rafi Shaik, Zuhur Jameel Qandeel Ali, Mujeeb Khan, Mufsir Kuniyil, Mohamed E Assal, Hamad Z Alkhathlan, Abdulrahman Al-Warthan, Mohammed Rafiq H Siddiqui, Merajuddin Khan, Syed Farooq Adil
The synthesis of Palladium (Pd) nanoparticles by green methods has attracted remarkable attention in recent years because of its superiority above chemical approaches, owing to its low cost and ecological compatibility. In this present work, we describe a facile and environmentally friendly synthesis of Pd nanoparticles (Pd NPs) using an aqueous extract of aerial parts of Origanum vulgare L. (OV) as a bioreductant. This plant is available in many parts of the world as well as in Saudi Arabia and is known to be a rich source of phenolic components, a feature we fruitfully utilized in the synthesis of Pd NPs, using various concentrations of plant extracts...
January 19, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28106801/o-carboxymethyl-chitosan-supported-heterogeneous-palladium-and-ni-catalysts-for-heck-reaction
#17
Dongjun Lv, Mingjie Zhang
Two polymer catalysts (Pd-OCMCS and Ni-OCMCS) with good reusability were synthesized by coordinating Pd and Ni onto O-carboxymethyl chitosan (OCMCS). The chemical structure and thermal stability of prepared catalysts were determined by Fourier transform infrared (FT-IR) spectra, Energy Dispersive Spectrometer (EDS)analysis, X-ray diffraction (XRD), and thermogravimetric analyzer (TG-DTG), and the analysis results showed that the Pd and Ni ions coordinated onto the OCMCS and formed a ligand with the -COOH group, amino groups, and -OH group on the OCMCS, and the EDS and Inductively Coupled Plasma Optical Emission Spectrometry (ICP-OES) analysis results showed that the loading amounts of Pd and Ni were approximately 8...
January 18, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28106615/metal-artifact-reduction-in-x-ray-computed-tomography-using-computer-aided-design-data-of-implants-as-prior-information
#18
Veikko Ruth, Daniel Kolditz, Christian Steiding, Willi A Kalender
OBJECTIVES: The performance of metal artifact reduction (MAR) methods in x-ray computed tomography (CT) suffers from incorrect identification of metallic implants in the artifact-affected volumetric images. The aim of this study was to investigate potential improvements of state-of-the-art MAR methods by using prior information on geometry and material of the implant. MATERIALS AND METHODS: The influence of a novel prior knowledge-based segmentation (PS) compared with threshold-based segmentation (TS) on 2 MAR methods (linear interpolation [LI] and normalized-MAR [NORMAR]) was investigated...
January 18, 2017: Investigative Radiology
https://www.readbyqxmd.com/read/28106383/synthesis-chemistry-and-electronic-structures-of-group-9-metallaboranes
#19
Rosmita Borthakur, Sourav Kar, Subrat Kumar Barik, Somnath Bhattacharya, Gargi Kundu, Babu Varghese, Sundargopal Ghosh
Dimetallaoctaborane(12) of Ru, Co, and Rh have been well-characterized by a range of spectroscopic techniques and X-ray diffraction studies. Thus, reinvestigation of the Ir-system became of interest. As a result, a slight modification in the reaction conditions enabled us to isolate the missing Ir analogue of octaborane(12), [(Cp*Ir)2B6H10], 1. Compound 1 adapts a geometry similar to that of its parent octaborane(12) and Ru, Co, and Rh analogues. In [M2B6H10+x](M = Ru, x = 2; M = Co and Rh, x = 0), there exist two M-H-B protons...
January 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28106382/lactide-as-the-playmaker-of-the-rop-game-theoretical-and-experimental-investigation-of-ring-opening-polymerization-of-lactide-initiated-by-aminonaphtholate-zinc-complexes
#20
Dawid Jędrzkiewicz, Grażyna Adamus, Michał Kwiecień, Łukasz John, Jolanta Ejfler
A family of homo- and heteroleptic zinc complexes bearing aminonaphtholate ligands was synthesized and fully characterized. Using NMR spectroscopy and DFT calculation, bis-alkoxy-bridged complexes [LZn(μ-OR)]2 were confirmed to have dimeric structures in solution, analogous to those obtained via X-ray crystallography. Surprisingly, a detailed experimental and theoretical study of the catalytic activity of [LZn(μ-OR)]2 in the ring-opening polymerization (ROP) of lactides showed that although well-defined alkoxy dimers possess a single-site structural motif, the most active initiator is obtained during in situ alcoholysis of the alkylzinc precursor...
January 20, 2017: Inorganic Chemistry
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