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https://www.readbyqxmd.com/read/28811812/lower-thoracic-syndrome
#1
Muhammad Nazim Farooq
The role of thoracic spine related dysfunction in producing lower extremity symptoms is not clear. This case study describes the assessment and treatment of a patient with low back pain and bilateral lower extremity (BLE) symptoms. It was found that patient education about postural awareness and passive mobilization are valuable aids to decrease BLE symptoms due to sympathetic nervous system (SNS) dysfunction and lower thoracic hypomobility. The clinicians need to consider examination and treatment of the lower thoracic area in patients with BLE symptoms...
May 2017: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/28810990/gait-and-functional-outcomes-for-young-active-males-with-traumatic-unilateral-transfemoral-limb-loss
#2
Caitlin E Mahon, Alison L Pruziner, Brad D Hendershot, Erik J Wolf, Benjamin J Darter, K Bo Foreman, Joseph B Webster
OBJECTIVE: Altered body structures that occur with the loss of a lower limb can impact mobility and quality of life. Specifically, biomechanical changes that result from wearing a prosthesis have been associated with an increased risk of falls or joint degeneration, as well as increased energy demands. While previous studies describing these outcomes are typically limited by number of outcome measures and/or small, diverse patient groups, recent military conflicts present a unique opportunity to collect outcomes from a relatively homogenous, active patient population with limb loss...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28809936/benefits-and-safety-of-gabapentinoids-in-chronic-low-back-pain-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#3
Harsha Shanthanna, Ian Gilron, Manikandan Rajarathinam, Rizq AlAmri, Sriganesh Kamath, Lehana Thabane, Philip J Devereaux, Mohit Bhandari
BACKGROUND AND OBJECTIVE: Chronic Low Back Pain (CLBP) is very common, with a lifetime prevalence between 51% and 80%. In majority, it is nonspecific in nature and multifactorial in etiology. Pregabalin (PG) and Gabapentin (GB) are gabapentinoids that have demonstrated benefit in neuropathic pain conditions. Despite no clear rationale, they are increasingly used for nonspecific CLBP. They necessitate prolonged use and are associated with adverse effects and increased cost. Recent guidelines from the National Health Service (NHS), England, expressed concerns on their off-label use, in addition to the risk of misuse...
August 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28807894/advances-in-the-diagnosis-and-management-of-neck-pain
#4
REVIEW
Steven P Cohen, W Michael Hooten
Neck pain imposes a considerable personal and socioeconomic burden-it is one of the top five chronic pain conditions in terms of prevalence and years lost to disability-yet it receives a fraction of the research funding given to low back pain. Although most acute episodes resolve spontaneously, more than a third of affected people still have low grade symptoms or recurrences more than one year later, with genetics and psychosocial factors being risk factors for persistence. Nearly half of people with chronic neck pain have mixed neuropathic-nociceptive symptoms or predominantly neuropathic symptoms...
August 14, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28807742/a-cost-utility-analysis-of-dynesys-dynamic-stabilization-versus-instrumented-fusion-for-the-treatment-of-degenerative-lumbar-spine-diseases
#5
Kan Liu, Wei Sun, Qiang Lu, Jiying Chen, Jiaguang Tang
BACKGROUND: Symptomatic chronic low back and leg pain resulting from lumbar spine degenerative disorders is highly prevalent in China, and for some patients, surgery is the final option for improvement. Several techniques for spinal non-fusion have been introduced to reduce the side-effects of fusion methods and hasten postoperative recovery. In this study, the authors have evaluated the cost-effectiveness of Dynesys posterior dynamic stabilization system (DY) compared with lumbar fusion techniques in the treatment of single-level degenerative lumbar spinal conditions...
August 11, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/28805759/-diagnosis-and-treatment-of-dorsopathy-in-patients-with-connective-tissue-dysplasia
#6
M L Chukhlovina, A A Chukhlovin
AIM: To study the pathogenesis, clinical manifestations and treatment of dorsopathy in patients with connective tissue dysplasia. MATERIAL AND METHODS: Thirty-six patients, aged from 18 to 45 years, with lumbar-sacral radiculopathies associated with connective tissue dysplasia were examined. Detailed neurological examination, X-ray visualization and MRI of lumbosacral spine section, electromyographic assessment were performed. A five-point scale of neuro-vertebrological symptoms, the Numerical Rating Scale (NRS) and the Roland-Morris Low Back Pain and Disability Questionnaire were used...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28804617/-typical-chiropractic-patients-can-they-be-described-in-terms-of-recovery-patterns
#7
Iben Axén, Charlotte Leboeuf-Yde
BACKGROUND: Chiropractors expect the typical patient to recover fully or to improve quickly with treatment if relapses occur. However, a mismatch between expectations and outcome would have a negative effect on both the chiropractors' professional self-esteem and patients' satisfaction with care. The prevalence of three types of recovery patterns among patients with non-specific low back pain (LBP) was calculated: 1: A full sustained recovery. 2: Initial recovery, but with one or several relapses followed by a period of recovery...
2017: Chiropractic & Manual Therapies
https://www.readbyqxmd.com/read/28802371/how-can-we-improve-medical-adherence-to-intranasal-corticosteroids-in-children
#8
Emre Ocak, Deniz Kocaoz, Baran Acar
OBJECTIVE: To evaluate the factors which may be related to nonadherence to intranasal corticosteroids (ICS) in the treatment of allergic rhinitis (AR) in children. METHODS: A prospective study was conducted on children with AR diagnosis in a tertiary referral hospital. All participants were provided with mometasone furoate nasal sprays for 30 days after the diagnosis. Caregivers were called back when the therapy was over and completed a questionnaire about the factors that may influence the adherence to the treatment...
September 2017: International Journal of Pediatric Otorhinolaryngology
https://www.readbyqxmd.com/read/28800306/acute-effects-of-kinesio-taping-on-pain-disability-and-back-extensor-muscle-endurance-in-patients-with-low-back-pain-caused-by-magnetic-resonance-imaging-confirmed-lumbar-disc-degeneration
#9
Nai-Jen Chang, Willy Chou, Pei-Chi Hsiao, Wen-Dien Chang, Yi-Ming Lo
BACKGROUND: Individuals with disc degeneration experience associated pain and disability. Considering its safety and affordability, Kinesio tape (KT) may be a viable treatment. However, most KT studies have demonstrated its effects in healthy adults and patients with nonspecific low back pain. The efficacy of KT in patients with disc degeneration is yet to be investigated. OBJECTIVES: To examine the acute effects of KT on patients with lumbar disc degeneration confirmed through magnetic resonance imaging...
August 4, 2017: Journal of Back and Musculoskeletal Rehabilitation
https://www.readbyqxmd.com/read/28791786/emergency-department-provider-perspectives-on-benzodiazepine-opioid-co-prescribing-a-qualitative-study
#10
Howard S Kim, Danielle M McCarthy, Jason A Hoppe, D Mark Courtney, Bruce L Lambert
OBJECTIVE: Benzodiazepines and opioids are prescribed simultaneously (i.e. "co-prescribed") in many clinical settings, despite guidelines advising against this practice and mounting evidence that concomitant use of both medications increases overdose risk. This study sought to characterize the contexts in which benzodiazepine-opioid co-prescribing occurs and providers' reasons for co-prescribing. METHODS: We conducted focus groups with ED providers (resident and attending physicians, advanced practice providers, and pharmacists) from three hospitals using semi-structured interviews to elicit perspectives on benzodiazepine-opioid co-prescribing...
August 9, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28783868/single-index-methods-for-evaluation-of-marker-guided-treatment-rules-based-on-multivariate-marker-panels
#11
Veronika Skrivankova, Patrick J Heagerty
Clinical practice may be enhanced by use of person-level information that could guide treatment choice and lead to better outcomes for both treated individuals and for the population. The scientific challenge is to identify and validate those factors that can reliably be used to target treatment, and to accurately quantify the expected treatment benefit as a function of candidate markers. Our proposal is to explicitly focus on smooth non-parametric evaluation of a canonical single index score that estimates the expected treatment benefit associated with patient characteristics...
August 7, 2017: Biometrics
https://www.readbyqxmd.com/read/28782309/study-of-seminal-fluid-parameters-and-fertility-of-male-sickle-cell-disease-patients-and-potential-impact-of-hydroxyurea-treatment
#12
Lulup Kumar Sahoo, Bipin Kishore Kullu, Siris Patel, Nayan Kumar Patel, Pragyan Rout, Prasanta Purohit, Satyabrata Meher
INTRODUCTION: Male Sickle cell disease (SCD) patients often have moderate to severe hypogonadism resulting in abnormal seminal fluid parameters due to testicular dysfunction. Hydroxyurea (HU), the only drug found to be effective in preventing morbidity and mortality in sickle cell disease patients has been found to further aggravate the testicular dysfunction. MATERIAL AND METHODS: This was a prospective study done at a tertiary care hospital over 26 months between September 2011 to October 2013...
June 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/28777064/is-fusion-necessary-for-thoracolumbar-burst-fracture-treated-with-spinal-fixation-a-systematic-review-and-meta-analysis
#13
Juliete M Diniz, Ricardo V Botelho
OBJECTIVE Thoracolumbar fractures account for 90% of spinal fractures, with the burst subtype corresponding to 20% of this total. Controversy regarding the best treatment for this condition remains. The traditional surgical approach, when indicated, involves spinal fixation and arthrodesis. Newer studies have brought the need for fusion associated with internal fixation into question. Not performing arthrodesis could reduce surgical time and intraoperative bleeding without affecting clinical and radiological outcomes...
August 4, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28776480/italian-adaptation-of-the-functional-outcome-questionnaire-aphasia-initial-psychometric-evaluation
#14
Simona Spaccavento, Elisabetta Cafforio, Fara Cellamare, Antonia Colucci, Angela Di Palma, Rosanna Falcone, Angela Craca, Anna Loverre, Roberto Nardulli, Robert L Glueckauf
PURPOSE: To evaluate the psychometric properties of the Italian version of Functional Outcome Questionnaire - Aphasia. METHODS: Two hundred and five persons with stroke-related aphasia and right hemiparesis who received ongoing assistance from a family caregiver were assessed using the Functional Outcome Questionnaire - Aphasia, Aachener Aphasie Test, Token Test, Raven's Coloured Progressive Matrices, Functional Independence Measure (FIM), Functional Assessment Measure (FAM), and Quality of Life Questionnaire for Aphasics (QLQA)...
August 4, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28770974/back-schools-for-chronic-non-specific-low-back-pain
#15
REVIEW
Patrícia Parreira, Martijn W Heymans, Maurits W van Tulder, Rosmin Esmail, Bart W Koes, Nolwenn Poquet, Chung-Wei Christine Lin, Christopher G Maher
BACKGROUND: Many people with low back pain (LBP) become frequent users of healthcare services in their attempt to find treatments that minimise the severity of their symptoms. Back School consists of a therapeutic programme given to groups of people that includes both education and exercise. However, the content of Back School has changed over time and appears to vary widely today. This review is an update of a Cochrane review of randomised controlled trials (RCTs) evaluating the effectiveness of Back School...
August 3, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28768775/the-surgical-treatment-of-non-specific-low-back-pain
#16
N V Todd
The National Institute for Health and Care Excellence has issued guidelines that state fusion for non-specific low back pain should only be performed as part of a randomised controlled trial, and that lumbar disc replacement should not be performed. Thus, spinal fusion and disc replacement will no longer be routine forms of treatment for patients with low back pain. This annotation considers the evidence upon which these guidelines are based. Cite this article: Bone Joint J 2017;99-B:1003-1005.
August 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/28768310/low-density-lipoprotein-cholesterol-treatment-in-the-proprotein-convertase-subtilisin-kexin-type-9-inhibitor-era-getting-back-on-target
#17
Marc S Sabatine, Robert P Giugliano
No abstract text is available yet for this article.
August 2, 2017: JAMA Cardiology
https://www.readbyqxmd.com/read/28767620/effects-of-training-and-overtraining-on-intervertebral-disc-proteoglycans
#18
Renato H S Ueta, Victor A F Tarini, Carlos E Franciozi, Marcel J S Tamaoki, Valquíria P Medeiros, Helena B Nader, Flávio Faloppa
STUDY DESIGN: Animal experimental study OBJECTIVE.: Evaluate the effect of physical activity and overtraining condition on glycosaminoglycan concentration on the intervertebral disc (IVD) using a rat running model. SUMMARY OF BACKGROUND DATA: Some guidelines recommend the implementation of a physical exercise program as treatment for low back pain, however cyclic loading impact on the health of the intervertebral disc and whether there is a dose-response relationship is still incompletely understood...
August 1, 2017: Spine
https://www.readbyqxmd.com/read/28767525/comparison-of-lower-limb-and-back-exercises-for-runners-with-chronic-low-back-pain
#19
Congcong Cai, Yifan Yang, Pui W Kong
INTRODUCTION: This single-blind randomized trial was conducted to compare the treatment effect of lower limb (LL) exercises versus conventional lumbar extensor (LE) and lumbar stabilization (LS) exercises in recreational runners with chronic low back pain (cLBP), since there is currently no specific protocol for managing runners with cLBP. METHODS: 84 recreational runners with cLBP were allocated to three exercise groups (LL, LE, LS) for an 8-week intervention. Outcome measures included self-rated pain and running capability, lower limb strength, back muscles function, and running gait...
July 31, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28765938/rapamycin-inhibits-spermatogenesis-by-changing-the-autophagy-status-through-suppressing-mechanistic-target-of-rapamycin-p70s6-kinase-in-male-rats
#20
Shangjing Liu, Longxian Huang, Yanqing Geng, Junlin He, Xuemei Chen, Hao Xu, Rong Li, Yingxiong Wang, Yubin Ding, Xueqing Liu
Rapamycin (sirolimus) is an antiproliferative drug that has been widely used in the clinic as an immunosuppressant and a potential anticancer agent. Certain reports have indicated that rapamycin may induce male infertility through impairing sperm quality. The present study investigated the mechanism of male infertility caused by rapamycin and examined whether withdrawal of rapamycin could recover the number of sperm in rats. Male Sprague‑Dawley rats (n=100) were divided randomly into 5 groups: 3 rapamycin‑treated groups (2, 4 and 6 mg/kg) and 2 control groups [Blank and dimethyl sulfoxide (DMSO)]...
July 31, 2017: Molecular Medicine Reports
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