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https://www.readbyqxmd.com/read/28635877/-a-neuropathic-component-of-lumboischialgia-mechanisms-of-development-and-treatment-approaches
#1
M V Churyukanov, G E Shevtsova, O I Zagorulko
Low back pain (LBP) is accompanied by the development of pain syndrome that spreads into the leg in 25-57% of patients. This is an important factor predicting the risk of transition of pain from acute to chronic and is an indirect indicator of disease severity. It is often impossible to specify the primary mechanism facilitated pain irradiation in lumboischialgia because many structures can cause analogous symptoms. Mechanisms of development of LBP are represented by nociceptive, neuropathic and psychogenic components...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28634583/circular-rnas-biogenesis-function-and-role-in-human-diseases
#2
REVIEW
John Greene, Anne-Marie Baird, Lauren Brady, Marvin Lim, Steven G Gray, Raymond McDermott, Stephen P Finn
Circular RNAs (circRNAs) are currently classed as non-coding RNA (ncRNA) that, unlike linear RNAs, form covalently closed continuous loops and act as gene regulators in mammals. They were originally thought to represent errors in splicing and considered to be of low abundance, however, there is now an increased appreciation of their important function in gene regulation. circRNAs are differentially generated by backsplicing of exons or from lariat introns. Unlike linear RNA, the 3' and 5' ends normally present in an RNA molecule have been joined together by covalent bonds leading to circularization...
2017: Frontiers in Molecular Biosciences
https://www.readbyqxmd.com/read/28632559/counting-the-cost-of-failed-spinal-fusion-for-relief-of-low-back-pain-does-primary-fusion-with-bone-morphogenetic-protein-make-economic-sense-from-a-primary-payer-perspective
#3
Adam P Lloyd
STUDY DESIGN: A retrospective cohort study. OBJECTIVES: To investigate the unknown direct costs of failed instrumented lumbar fusion using iliac crest bone graft (ICBG) and subsequent reoperation utilizing recombinant human bone morphogenetic protein-2 (rhBMP-2) from a primary payer perspective. SUMMARY OF BACKGROUND DATA: Recent evidence has demonstrated increased rates of instrumented lumbar fusion and utilization of rhBMP-2 to treat a range of conditions causing lower back pain...
July 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28632555/changes-in-cytokines-sensory-tests-and-self-reported-pain-levels-after-manual-treatment-of-low-back-pain
#4
Brian F Degenhardt, Jane C Johnson, Christian Fossum, Chad T Andicochea, Melissa K Stuart
STUDY DESIGN: Unbalanced 3-factor design with repeated measures on 1 factor. OBJECTIVE: To determine the effect of manual treatment (MT) on cytokine and pain sensations in those with and without low back pain (LBP). SUMMARY OF BACKGROUND DATA: Evidence suggests that MT reduces LBP but by unknown mechanisms. Certain cytokines have been elevated in patients with LBP and may be affected by MT. METHODS: Participants aged 20-60 years with chronic LBP or without LBP were recruited and randomly assigned to MT, sham ultrasound treatment, or no treatment groups...
July 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28632548/are-modic-changes-able-to-help-us-in-our-clinical-practice-a-study-of-the-modic-changes-in-young-adults-during-working-age
#5
José V Martínez-Quiñones, José Aso-Escario, Laura González-García, Fabián Consolini, Ricardo Arregui-Calvo
STUDY DESIGN: Modic changes [vertebral endplate spinal changes (VESC)] have been related to degenerative disk disease, and in past decades it was thought that their presence justified the surgical treatment, in particular spinal fusion. OBJECTIVE: The aim of the present study is to investigate its prevalence and features in a population of young workers suffering from low back pain, and explore the eventual relationship with the treatment applied in each case. BACKGROUND DATA: We conducted a retrospectively review of 450 magnetic resonance images from our hospital, in patients with low back pain or sciatica and age below 40...
July 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28631465/an-interfacial-investigation-on-printable-carbon-based-mesoscopic-perovskite-solar-cells-with-niox-c-back-electrode
#6
Fatemeh Behrouznejad, Cheng-Min Tsai, Sudhakar Narra, Eric W-G Diau, Nima Taghavinia
Solar cells with high-efficiency, low-cost and high-stability are the target for the new generation of solar cells. A fully printable perovskite (CH3NH3PbI3) solar cell (PSC) with device architecture FTO/TiO2/Al2O3/NiOx/C is fabricated in the current research as a low-cost and relatively stable structure and is investigated to determine how different fabrication factors such as the thickness of the insulating spacer layer (Al2O3) or treatments such as heat and UV-O3 treatments can affect the interfacial properties of this multi-layer mesoporous structure...
June 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28631003/yoga-physical-therapy-or-education-for-chronic-low-back-pain-a-randomized-noninferiority-trial
#7
Robert B Saper, Chelsey Lemaster, Anthony Delitto, Karen J Sherman, Patricia M Herman, Ekaterina Sadikova, Joel Stevans, Julia E Keosaian, Christian J Cerrada, Alexandra L Femia, Eric J Roseen, Paula Gardiner, Katherine Gergen Barnett, Carol Faulkner, Janice Weinberg
Background: Yoga is effective for mild to moderate chronic low back pain (cLBP), but its comparative effectiveness with physical therapy (PT) is unknown. Moreover, little is known about yoga's effectiveness in underserved patients with more severe functional disability and pain. Objective: To determine whether yoga is noninferior to PT for cLBP. Design: 12-week, single-blind, 3-group randomized noninferiority trial and subsequent 40-week maintenance phase...
June 20, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28630974/guideline-in-low-back-pain-nonpharmacologic-treatments-are-recommended
#8
Simon Somerville
No abstract text is available yet for this article.
June 20, 2017: Annals of Internal Medicine
https://www.readbyqxmd.com/read/28629805/association-of-hip-radiograph-findings-with-pain-and-function-in-patients-presenting-with-low-back-pain
#9
Heidi Prather, Abby Cheng, Karen Steger May, Vaibhav Maheshwari, Linda VanDillen
BACKGROUND: Relationships between low back pain (LBP) and the hip in patient cohorts have been described primarily in patients with moderate to severe hip osteoarthritis (OA). Less is known about the links of LBP with hip radiographic findings of hip deformity and minimal OA. OBJECTIVE: The objectives were to 1) describe the incidence of radiographic hip deformity or hip OA, 2) describe and compare spine and hip related pain and function in the subset of patients who were found to have radiographic hip deformity or hip OA, and (3) compare patients with evidence of radiographic hip deformity or hip OA to patients without hip radiographic findings...
June 16, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28625997/quantifying-vibrio-cholerae-enterotoxicity-in-a-zebrafish-infection-model
#10
Kristie C Mitchell, Paul Breen, Sarah Britton, Melody N Neely, Jeffrey H Withey
Vibrio cholerae is the etiological agent of cholera, an acute intestinal infection in humans characterized by voluminous watery diarrhea. Cholera is spread through ingestion of contaminated food or water, primarily in developing countries that lack the proper infrastructure for proper water and sewage treatment. Vibrio cholerae is an aquatic bacterium that inhabits coastal and estuarine areas, and is known to have several environmental reservoirs, including fish. Our laboratory has recently described the use of the zebrafish as a new animal model for the study of V...
June 16, 2017: Applied and Environmental Microbiology
https://www.readbyqxmd.com/read/28624722/age-related-differences-in-the-response-of-the-l5-s1-intervertebral-disc-to-spinal-traction
#11
Ulrike H Mitchell, Paul F Beattie, Jennifer Bowden, Robert Larson, Hanuan Wang
BACKGROUND: Lumbar traction is a common treatment for low back pain; however its mechanisms of action are poorly understood. It has been hypothesized that a key effect of lumbar traction is its capacity to influence fluid movement within the intervertebral disc (IVD). OBJECTIVES: To determine differences in the apparent diffusion coefficient (ADC) obtained with lumbar diffusion-weighted imaging (DWI) of the L5-S1 IVD before, and during, the application of lumbar traction...
June 9, 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/28619301/the-effects-of-gua-sha-on-symptoms-and-inflammatory-biomarkers-associated-with-chronic-low-back-pain-a-randomized-active-controlled-crossover-pilot-study-in-elderly
#12
John W M Yuen, William W N Tsang, Sonny H M Tse, Wings T Y Loo, Suk-Tak Chan, Diana L Y Wong, Hilary H Y Chung, Jacky K K Tam, Thomas K S Choi, Vico C L Chiang
OBJECTIVE: To address the challenges for trialing with elderly and the lacking of valid sham/placebo control, a randomized crossover pilot study is designed and its feasibility on elderly subjects is evaluated. DESIGN: A pilot randomized crossover study was conducted with hydrocollator-based hot pack therapy as active control. Pain intensity, physical disability, depression, general health status, and salivary biomarkers were assessed as outcome measures. RESULTS: Despite there was no significant difference observed between any outcome measures attained by the two interventions, several important differences were noted during the one-week follow-up period...
June 2017: Complementary Therapies in Medicine
https://www.readbyqxmd.com/read/28617390/-pathopsychological-aspects-of-low-back-pain
#13
A I Krupatkin, A A Kuleshov, T V Sokolova, A O Gospod
Low back pain is one of the most common causes of disability in the world. Discogenic process is the leading component of the disease. A significant part of these pain syndromes become chronic that leads to disability and social maladjustment. Chronic low back pain is hard to treat due to the several types of pathogenesis. The paper analyzes the etiology, mechanisms of development, clinical features, specific characteristics, pathomorphology of the formation of psychogenic component of pain. A role of comorbid psychogenic states involved in the chronization of low back pain is considered...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
https://www.readbyqxmd.com/read/28615337/accumulation-of-methylglyoxal-increases-the-advanced-glycation-end-products-levels-in-drg-and-contributes-to-lumbar-disc-herniation-induced-persistent-pain
#14
Cui-Cui Liu, Xin-Sheng Zhang, Yu-Ting Ruan, Zhu-Xi Huang, Su-Bo Zhang, Meng Liu, Hai-Jie Luo, Shao-Ling Wu, Chao Ma
Lumbar disc herniation (LDH) with discogenic low back pain and sciatica is a common and complicated musculoskeletal disorder. The underlying mechanisms are poorly understood and there are no effective therapies for LDH-induced pain. In the present study, we found that the patients who suffered from LDH-induced pain had elevated plasma methylglyoxal (MG) levels. In rats, implantation of autologous nucleus pulposus (NP) to the left lumbar 5 spinal nerve root, which mimicked LDH, induced mechanical allodynia and increased MG level in plasma and dorsal root ganglion (DRG) and enhanced the excitability of small DRG neurons (< 30μm in diameter)...
June 14, 2017: Journal of Neurophysiology
https://www.readbyqxmd.com/read/28614539/effects-of-ozone-on-the-pain-and-disability-in-patients-with-failed-back-surgery-syndrome
#15
Danilo Costa Barbosa, Jairo Silva Dos Ângelos, Gleica Maria Josino de Macena, Francisco Nêuton de Oliveira Magalhães, Erich Talamoni Fonoff
Introduction: Low back pain is one of the painful disorders of higher prevalence. It has several etiologies and surgery may be indicated in the presence of neurological deficits or compression syndromes. However, in up to 40% of cases, patients develop worsening of pain and failed back surgery syndrome (FBSS), which is an important cause of chronic pain with high morbidity and disability. In the last two decades, ozone has been shown to be a new therapeutic option for FBSS due to its analgesic and anti-inflammatory properties...
April 2017: Revista da Associação Médica Brasileira
https://www.readbyqxmd.com/read/28614434/post-stroke-psychosis-how-long-should-we-treat
#16
Maria do Céu Ferreira, Célia Machado, Beatriz Santos, Álvaro Machado
Objective: To describe a rare case of a patient who developed psychotic symptoms after a right stroke that disappeared with antipsychotic treatment, but appears to need low-dose maintenance antipsychotic therapy. Case description: A 65-year-old man presented at the psychiatric emergency service with a history of persistent delusional jealousy, visual illusions and agitation with onset about 1 month after a right posterior cerebral artery ischemic stroke. These symptoms only disappeared with therapeutic dosages of an antipsychotic drug (3 mg/day of risperidone)...
June 12, 2017: Trends in Psychiatry and Psychotherapy
https://www.readbyqxmd.com/read/28614188/placebo-effects-of-a-sham-opioid-solution-a-randomized-controlled-study-in-patients-with-chronic-low-back-pain
#17
Regine Klinger, Ralph Kothe, Julia Schmitz, Sandra Kamping, Herta Flor
This study tested the experimental placebo effect in a group of chronic pain patients. Forty-eight patients suffering from chronic back pain participated in a randomized clinical trial that tested the efficacy of a sham opioid solution (NaCl) compared to an alleged neutral, completely inactive solution (NaCl). We shaped the placebo effect by two interventions: suggestion/instruction and conditioning. The patients were either told that the "solution reduces pain/improves physical capacity" or the "solution is neutral, a placebo"...
June 9, 2017: Pain
https://www.readbyqxmd.com/read/28611931/spontaneous-rupture-of-renal-metastasis-from-hepatocellular-carcinoma
#18
Osamu Kinoshita, Yusuke Ichijo, Masayuki Yoneda, Atsushi Ikai, Tetsuro Yamashita
We report a rare life-threatening case of spontaneous rupture of renal metastasis from hepatocellular carcinoma (HCC) that was managed by emergent transcatheter arterial embolization (TAE). A 76-year-old woman diagnosed with HCC presented with acute back pain in her right side and was transferred to our hospital. Initial enhanced computed tomography revealed retroperitoneal hemorrhage from the right kidney, which was retrospectively diagnosed as a spontaneous rupture of the metastatic renal tumor from the primary HCC...
2017: Case Reports in Surgery
https://www.readbyqxmd.com/read/28609520/nsaids-for-chronic-low-back-pain
#19
Wendy T M Enthoven, Pepijn D Roelofs, Bart W Koes
Clinical Question: Are nonsteroidal anti-inflammatory drugs (NSAIDs) associated with greater pain relief than placebo, other drugs, and nondrug treatments for patients with chronic low back pain? Bottom Line: Compared with placebo, NSAIDs are associated with a small but significant improvement in pain and disability in patients with chronic low back pain, although this difference became nonsignificant when studies with high risk for bias were excluded. The associated benefits were smaller than the minimal clinically important difference...
June 13, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28606017/histoplasmosis-mimicking-metastatic-spinal-tumour
#20
Bing Liu, Liyan Qu, Jian Zhu, Zhengming Yang, Shigui Yan
Histoplasmosis is an infection caused by a fungus called Histoplasma. Diagnosis of histoplasmosis is based on the culture of biological samples and detection of fungus in tissues. Histoplasmosis can mimic malignant lesions. We report a 65-year-old, immunocompetent, male patient with back pain. We describe the main clinical and radiological characteristics in our patient who had vertebral histoplasmosis that mimicked cancer. A computed tomography scan showed lytic lesions of the right side of T4, T5, and T6 vertebral bodies...
January 1, 2017: Journal of International Medical Research
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