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https://www.readbyqxmd.com/read/28344100/facilitated-pro-nociceptive-pain-mechanisms-in-radiating-back-pain-compared-with-localized-back-pain
#1
Henrik Bjarke Vaegter, Thorvaldur Skuli Palsson, Thomas Graven-Nielsen
Facilitated pain mechanisms and impaired pain inhibition are often found in chronic pain patients. This study compared clinical pain profiles, pain sensitivity, as well as pro-nociceptive and anti-nociceptive mechanisms in patients with localized low back pain (n=18), localized neck pain (n=17), low back and radiating leg pain (n=18), or neck and radiating arm pain (n=17). It was hypothesized that patients with radiating pain had facilitated pain mechanisms and impaired pain inhibition compared with localized pain patients...
March 23, 2017: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/28343048/protective-effect-of-cddo-ea-against-high-glucose-induced-oxidative-injury-via-the-nrf2-ho-1-pathway
#2
Cun-Xin Zhang, Ting Wang, Jin-Feng Ma, Yang Liu, Zheng-Gang Zhou, De-Chun Wang
BACKGROUND CONTEXT: Intervertebral disc degeneration (IDD) is the main cause of low back pain, and nucleus pulposus (NP) cell apoptosis is an important risk factor of IDD. However, the molecular mechanism of this disease remains unknown. PURPOSE: To assess the potential protective effect of CDDO-ethyl amide (EA) against high-glucose-induced oxidative stress injury in NP cells and to investigate the mechanism of antioxidative effects and apoptotic inhibition. STUDY DESIGN/SETTING: To find new molecule to inhibit intervertebral disc degeneration...
March 22, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28340111/assessment-of-patient-reported-outcome-instruments-to-assess-chronic-low-back-pain
#3
Abhilasha Ramasamy, Mona L Martin, Steven I Blum, Hiltrud Liedgens, Charles Argoff, Rainer Freynhagen, Mark Wallace, Kelly P McCarrier, Donald M Bushnell, Noël V Hatley, Donald L Patrick
Objective. : To identify patient-reported outcome (PRO) instruments that assess chronic low back pain (cLBP) symptoms (specifically pain qualities) and/or impacts for potential use in cLBP clinical trials to demonstrate treatment benefit and support labeling claims. Design. : Literature review of existing PRO measures. Methods. : Publications detailing existing PRO measures for cLBP were identified, reviewed, and summarized. As recommended by the US Food & Drug Administration (FDA) PRO development guidance, standard measurement characteristics were reviewed, including development history, psychometric properties (validity and reliability), ability to detect change, and interpretation of observed changes...
March 6, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28340086/real-world-massage-therapy-produces-meaningful-effectiveness-signal-for-primary-care-patients-with-chronic-low-back-pain-results-of-a-repeated-measures-cohort-study
#4
William G Elder, Niki Munk, Margaret M Love, Geza G Bruckner, Kathryn E Stewart, Kevin Pearce
Objective.:  While efficacy of massage and other nonpharmacological treatments for chronic low back pain is established, stakeholders have called for pragmatic studies of effectiveness in "real-world" primary health care. The Kentucky Pain Research and Outcomes Study evaluated massage impact on pain, disability, and health-related quality of life for primary care patients with chronic low back pain. We report effectiveness and feasibility results, and make comparisons with established minimal clinically important differences...
March 14, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28339442/clinical-outcome-of-full-endoscopic-interlaminar-discectomy-for-single-level-lumbar-disc-herniation-a-minimum-of-5-year-follow-up
#5
Zhiming Tu, Ya Wei Li, Bing Wang, Guohua Lu, Lei Li, Lei Kuang, Yuliang Dai
BACKGROUND: Full-endoscopic interlaminar discectomy (FEID) is widely applied for the treatment of lumbar disc herniation (LDH) and satisfactory short-term outcomes have been achieved. However, the long-term evaluation for this technique is still lacking, especially the comparison between FEID and microendoscopic discectomy (MED). OBJECTIVE: To evaluate the clinical outcome of FEID technique in comparison with MED for single-level LDH with a minimum of 5-year follow-up...
March 2017: Pain Physician
https://www.readbyqxmd.com/read/28339334/a-movement-system-impairment-approach-to-evaluation-and-treatment-of-a-person-with-lumbar-radiculopathy-a-case-report
#6
Eileen Miller, Shirley A Sahrmann, Dale Avers
BACKGROUND AND PURPOSE: There are several systems of classification and treatment of patients with low back pain (LBP) based on assessment of the effect of lumbar postures and movements on symptoms. The efficacy of one of these systems, The Movement System Impairment (MSI) method, has not yet been demonstrated in the literature. The purpose of this case report is to describe the approach of the MSI method for an individual with lumbar radiculopathy. CASE DESCRIPTION: A 79-year-old woman with a history of chronic LBP was referred to PT with a physician's diagnosis of sciatica...
March 2017: Physiotherapy Theory and Practice
https://www.readbyqxmd.com/read/28336484/lumbar-mri-findings-in-patients-with-and-without-waddell-signs
#7
J S Cox, S Blizzard, H Carlson, J Hiratza, J U Yoo
BACKGROUND CONTEXT: Waddell Signs (WS), introduced as a method to establish patients with substantial psychosocial components to their low back pain, carry a negative association despite no literature evaluating whether physical disease is associated with them. PURPOSE: To compare lumbar MRI findings between the patients with and without Waddell's Signs. STUDY DESIGN: Retrospective cohort study based on prospectively collected data PATIENT SAMPLE: Thirty patients aged 35-55 with an ODI score >50 randomly selected such that there was an even distribution of patients based on number of WS OUTCOME MEASURES: ODI and SF-12 scores, number of WS, presence and severity of spinal pathology METHODS: MRIs were reviewed by three spine specialists blinded to clinical exam findings, number of WS, and patient identity...
March 20, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28336436/induction-of-dopamine-d1-and-d5-receptors-in-r28%C3%A2-cells-by-light-exposures
#8
Yan Ke, Wentao Li, Zhiqun Tan, Zhikuan Yang
Dopamine is known to play an important role in the pathophysiological process of myopia development relevant to the ambient lighting, but it is still poorly understood about how lighting regulates dopamine and its interaction with dopamine receptors to mediate the pathogenic signal transduction leading to alterations of ocular globe and the pathogenesis of myopia. Many studies have highlighted changes of ocular dopamine amount in response to different lighting conditions, but little attention has been paid to the dopamine receptors during these processes...
March 20, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28334783/amitriptyline-for-musculoskeletal-complaints-a-systematic-review
#9
Jacoline J van den Driest, Sita M A Bierma-Zeinstra, Patrick J E Bindels, Dieuwke Schiphof
Background.: The role of amitriptyline in musculoskeletal pain is not as clearly defined as in classical neuropathic pain conditions. Objective.: To assess the efficacy and effectiveness of amitriptyline in the treatment of pain in musculoskeletal complaints. Methods.: An extensive search (including Medline, Embase and Web of Science) was made up to April 2016 for randomised controlled trials on amitriptyline in musculoskeletal complaints compared to placebo, usual care, or other analgesic use...
January 30, 2017: Family Practice
https://www.readbyqxmd.com/read/28334018/development-of-an-evidence-evaluation-and-synthesis-system-for-drug-drug-interactions-and-its-application-to-a-systematic-review-of-hiv-and-malaria-co-infection
#10
Kay Seden, Sara Gibbons, Catia Marzolini, Jonathan M Schapiro, David M Burger, David J Back, Saye H Khoo
BACKGROUND: In all settings, there are challenges associated with safely treating patients with multimorbidity and polypharmacy. The need to characterise, understand and limit harms resulting from medication use is therefore increasingly important. Drug-drug interactions (DDIs) are prevalent in patients taking antiretrovirals (ARVs) and if unmanaged, may pose considerable risk to treatment outcome. One of the biggest challenges in preventing DDIs is the substantial gap between theory and clinical practice...
2017: PloS One
https://www.readbyqxmd.com/read/28330796/chronic-low-back-pain-after-lumbosacral-fracture-due-to-sagittal-and-frontal-vertebral-imbalance
#11
L Boyoud-Garnier, M Boudissa, S Ruatti, G Kerschbaumer, P Grobost, J Tonetti
PROBLEM AND HYPOTHESIS: Over time, some patients with unilateral or bilateral lumbosacral injuries experience chronic low back pain. We studied the sagittal and frontal balance in a population with these injuries to determine whether mismatch in the pelvic and lumbar angles are associated with chronic low back pain. PATIENTS AND METHODS: Patients with posterior pelvic ring fractures (Tile C1, C2, C3 and A3.3) that had healed were included. Foreign patients and those with an associated spinal or acetabular fracture or nonunion were excluded...
March 19, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28328552/il-1%C3%AE-levels-are-associated-with-chronic-multisite-pain-in-people-living-with-hiv
#12
Jessica S Merlin, Andrew O Westfall, Sonya L Heath, Burel R Goodin, Jesse C Stewart, Robert E Sorge, Jarred Younger
BACKGROUND: The pathophysiology of chronic pain experienced by people living with HIV (PLWH) in the current antiretroviral treatment era is poorly understood. We sought to investigate the relationship between inflammation and chronic pain in PLWH. We hypothesized that, among PLWH who have undetectable HIV viral loads, those with Chronic Multisite Pain (CMP) would have higher levels of circulating pain-related inflammatory markers than those without chronic pain. SETTING: This study was conducted at the University of Alabama at Birmingham's Center for AIDS Research Network of Integrated Clinical System (CNICS) site...
March 20, 2017: Journal of Acquired Immune Deficiency Syndromes: JAIDS
https://www.readbyqxmd.com/read/28327997/lumbar-fusion-for-degenerative-disease-a-systematic-review-and-meta-analysis
#13
Daniel Yavin, Steven Casha, Samuel Wiebe, Thomas E Feasby, Callie Clark, Albert Isaacs, Jayna Holroyd-Leduc, R John Hurlbert, Hude Quan, Andrew Nataraj, Garnette R Sutherland, Nathalie Jette
BACKGROUND: Due to uncertain evidence, lumbar fusion for degenerative indications is associated with the greatest measured practice variation of any surgical procedure. OBJECTIVE: To summarize the current evidence on the comparative safety and efficacy of lumbar fusion, decompression-alone, or nonoperative care for degenerative indications. METHODS: A systematic review was conducted using PubMed, MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials (up to June 30, 2016)...
March 17, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28327190/primary-pain-generator-identification-by-ct-spect-in-a-patient-with-low-back-pain-a-case-report
#14
Gabriel Tender, Adriana Constantinescu, Andrew Conger, Anthony DiGiorgio
BACKGROUND: Chronic low back pain is one of the most common conditions encountered in the middle-age population. Identifying the primary pain generator is notoriously difficult. The computed tomography-single-photon emission computed tomography (CT-SPECT) is emerging as a new diagnostic modality for this purpose. CASE PRESENTATION: This 68-year-old Caucasian male presented with intractable low back pain refractory to maximal conservative treatment, including medication and extensive physical therapy...
March 21, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28327115/clinically-acceptable-agreement-between-the-vimove-wireless-motion-sensor-system-and-the-vicon-motion-capture-system-when-measuring-lumbar-region-inclination-motion-in-the-sagittal-and-coronal-planes
#15
Hanne Leirbekk Mjøsund, Eleanor Boyle, Per Kjaer, Rune Mygind Mieritz, Tue Skallgård, Peter Kent
BACKGROUND: Wireless, wearable, inertial motion sensor technology introduces new possibilities for monitoring spinal motion and pain in people during their daily activities of work, rest and play. There are many types of these wireless devices currently available but the precision in measurement and the magnitude of measurement error from such devices is often unknown. This study investigated the concurrent validity of one inertial motion sensor system (ViMove) for its ability to measure lumbar inclination motion, compared with the Vicon motion capture system...
March 21, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28327082/out-of-hours-care-in-germany-high-utilization-by-adult-patients-with-minor-ailments
#16
R Leutgeb, P Engeser, S Berger, J Szecsenyi, G Laux
BACKGROUND: Family practitioners (FPs) who work in Out-Of-Hours Care (OOHC) - especially in rural areas - complain about high workload related to low urgency and potentially unnecessary patient presentations with minor ailments. The aim of this study was to describe Reasons for Encounter (RFEs) in primary OOHC taken into account the doctor's perspective in the context of high workload without knowing patients' motives for visiting an OOHC-centre. METHODS: Within this descriptive study, OOHC data from 2012 were evaluated from a German statutory health insurance company in the federal state of Baden-Wuerttemberg...
March 21, 2017: BMC Family Practice
https://www.readbyqxmd.com/read/28324797/consistency-of-a-lumbar-movement-pattern-across-functional-activities-in-people-with-low-back-pain
#17
Andrej V Marich, Ching-Ting Hwang, Gretchen B Salsich, Catherine E Lang, Linda R Van Dillen
BACKGROUND: Limitation in function is a primary reason people with low back pain seek medical treatment. Specific lumbar movement patterns, repeated throughout the day, have been proposed to contribute to the development and course of low back pain. Varying the demands of a functional activity test may provide some insight into whether people display consistent lumbar movement patterns during functional activities. Our purpose was to examine the consistency of the lumbar movement pattern during variations of a functional activity test in people with low back pain and back-healthy people...
March 7, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/28324215/surgical-treatment-of-osteoporotic-thoraco-lumbar-compressive-fractures-the-use-of-pedicle-screw-with-augmentation-pmma
#18
Massimo Girardo, P Cinnella, G Gargiulo, P Viglierchio, A Rava, S Aleotti
INTRODUCTION: The osteoporosis prevalence in population is age related. The aim of this single-center observational study was evaluate the middle- to long-term performance of cement (PMMA) augmented fenestrated pedicle screws in elderly patients with thoraco-lumbar compressive fractures by osteoporosis. MATERIALS AND METHODS: From 2011 to 2015 we treated 52 patients (20 males and 32 females) suffering from somatic osteoporotic fractures (T10-L2). The average age was 73...
March 21, 2017: European Spine Journal
https://www.readbyqxmd.com/read/28323705/etiology-of-adult-onset-stress-fracture-in-the-lumbar-spine
#19
Fumitake Tezuka, Koichi Sairyo, Toshinori Sakai, Akira Dezawa
STUDY DESIGN: This study was a case series. OBJECTIVE: The purpose of this paper was to present a case series of fresh stress fractures (spondylolysis) in the lumbar spines of adult athletes. SUMMARY OF BACKGROUND DATA: Lumbar spondylolysis is a stress fracture of the pars interarticularis, which is generally considered a disease of children or adolescence. There is only 1 case series written in English reporting on adult-onset fresh spondylolysis...
April 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28323695/superior-recess-access-of-the-lumbar-facet-joint
#20
Sibel Demir-Deviren, Sukhminder Singh, Joshua Hanelin
STUDY DESIGN: Descriptive approach to accessing the lumbar facet joint by superior recess. OBJECTIVE: This study is aimed to describe an approach to accessing the lumbar facet joint through targeting the superior recess during lumbar facet joint injections. SUMMARY OF BACKGROUND DATA: Lumbar facet joint injections are routinely performed for both the diagnosis and treatment of chronic low back pain. Previous studies either did not specify which part of the joint to target, or recommended targeting the inferior aspect of the joint to access the inferior recess...
April 2017: Clinical Spine Surgery
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