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M Khetta, Y Benhamou, C Tharasse, M Le Besnerais, S Miranda, N Cailleux-Talbot, N Girszyn, S Ngo, G Sauvêtre, H Lévesque, G Armengol
PURPOSE: More than one million patients received an oral anticoagulant treatment in France. This medication is the first aetiology of iatrogenic events. Recently, direct oral anticoagulant (DOA) provided efficacy and safety in the treatment of atrial fibrillation and venous thromboembolic events. Given the growing increase in the prescription of these molecules, with many advantages but also disadvantages, it seemed interesting to assess in routine hospital medical practice, the proportion of patients for which the initiation of AOD could be safe...
December 2015: La Revue de Médecine Interne
Xiaobei Zheng, Juan Li, Zhengwang Chen, Yimei Liu, Keli Chen
BACKGROUND: Dried Whitmania pigra is used for the treatment of cardiovascular and cerebrovascular diseases in traditional Chinese medicine and hot water and alcohol extracts also have anticogulant activity. However, a lower molecular weight and more stable anticogulant is needed. OBJECTIVE: The objective of the following study is to purify and characterize of an anticoagulant oligopeptide from Hirudo (Whitmania pigra Whitman). MATERIALS AND METHODS: Gel filtration on Sephadex G-50, ion exchange on diethylaminoethyl-cellulose, and semi-prepared high-performance liquid chromatography were used to purify Hirudo...
July 2015: Pharmacognosy Magazine
Shannon Cope, Andreas Clemens, Florence Hammès, Herbert Noack, Jeroen P Jansen
OBJECTIVES: To critically appraise published network meta-analyses (NMAs) evaluating the efficacy or safety of the new oral anticogulants (NOACs) dabigatran, rivaroxaban, and apixaban for the prevention of stroke in patients with nonvalvular atrial fibrillation (AF). METHODS: A systematic literature review was performed to identify the relevant NMAs using MEDLINE, EMBASE, Cochrane Library, Database of Abstracts of Reviews of Effects, and Health Technology Assessment...
March 2015: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
Fernando Veiga Fernández, María del Rocío Malfeito Jiménez, Sonia María Barros Cerviño, María del Mar Magariños Losada
Anticoagulation in elderly people with non-valvular atrial afibrillation (AF) is a challenge, due to the thromboembolic, as well as the haemorrhagic risks. The correct use of anticoagulants in these patients has shown a higher net clinical benefit when comparing it with a younger population. Non-vitamin K antagonist oral anticoagulants (NOACs) have been compared to oral vitamin K antagonists in several studies that included a sufficient number of elderly people. Favourable results for non-vitamin K antagonist oral anticoagulants were obtained in these studies, making them the preferred treatment for this group of patients...
May 2015: Revista Española de Geriatría y Gerontología
Li Dong, Yingkang Shi, Bo Fu, Xiao Teng, Jin Chen, Bengui Zhang
OBJECTIVE: To investigate the safety and efficacy of low intensity anticogulation therapy for chinese population underwent heart valve replacemnt. METHODS: From January 1999 to October 2010, the literatures concering anticoagulation therapy for chinese population with heart valve replacement were researched in following databases: CBM, CNKI, VIP, Pubmed as well as cochrane library. Screening and quality evaluation was conducted according to the inclusion and exclusion criteria...
September 16, 2014: Zhonghua Yi Xue za Zhi [Chinese medical journal]
Ilknur Mutlu, Mehmet Firat Mutlu, Aydan Biri, Berk Bulut, Mehmet Erdem, Ahmet Erdem
This study investigates the effects of anticoagulant therapy on pregnancy outcomes in 204 patients with thrombophilia and previous poor obstetric outcomes. Patients with poor obstetric history (pre-eclampsia, intrauterine growth retardation, fetal death, placental abruption, recurrent pregnancy loss) and having hereditary thrombophilia were included in this study. Poor obstetric outcomes were observed more frequently in patients who had not taken anticogulant therapy compared with treated group. Live birth rate, gestational age at birth and Apgar scores were significantly higher in the treated group when compared with the untreated group...
April 2015: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
Osman Oguz, Berrin Bercik Inal, Turker Emre, Oguzhan Ozcan, Esma Altunoglu, Gokce Oguz, Cigdem Topkaya, Guvenc Guvenen
BACKGROUND: Advanced oxidation protein product (AOPP) was first described as an oxidative protein marker in chronic uremic patients and measured with a semi-automatic end-point method. Subsequently, the kinetic method was introduced for AOPP assay. We aimed to compare these two methods by adapting them to a chemistry analyzer and to investigate the correlation between AOPP and fibrinogen, the key molecule responsible for human plasma AOPP reactivity, microalbumin, and HbA1c in patients with type II diabetes mellitus (DM II)...
2014: Clinical Laboratory
R Dissmann, L J Cromme, A Salzwedel, U Taborski, J Kunath, F Gäbler, K Heyne, H Völler
UNLABELLED: A recently developed multiparameter computer-aided expert system (TheMa) for guiding anticoagulation with phenprocoumon (PPC) was validated by a prospective investigation in 22 patients. The PPC-INR-response curve resulting from physician guided dosage was compared to INR values calculated by "twin calculation" from TheMa recommended dosage. Additionally, TheMa was used to predict the optimal time to perform surgery or invasive procedures after interruption of anticogulation therapy...
2014: Hämostaseologie
Lena Kesy, Przemysław Kopczyński, Aleksandra Baszczuk, Zygmunt Kopczyński
Platelet rich plasma is being increasingly used in the modem medicine as a material, stimulating regeneration and accelerating tissue healing. Platelet rich plasma is an autologous platelet concentrate, which is obtained from the peripheral blood of the patient. The method of extraction is based on the isolation of platelets during centrifugation of the whole blood, drew on anticoagulant. With the difference in density between the various cellular components of blood, such as red blood cells, buffy coat and platelet poor plasma, the separation into individual fractions is possible...
April 2014: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
A J Wagstaff, T F Overvad, G Y H Lip, D A Lane
BACKGROUND: Atrial fibrillation (AF) increases the risk of stroke, but this risk is not homogenous. Many risk factors contribute to stroke risk however, the evidence for female sex as a risk factor is less well-established. AIM: To perform a systematic review and meta-analysis of the available evidence to establish if female sex is a risk factor for stroke/thromboembolism among patients with AF. METHODS: A systematic literature search was conducted using Medline...
December 2014: QJM: Monthly Journal of the Association of Physicians
Wen-Juan Shi, Hong Wan, Jian Zhou, Li Wei, Zheng-Mao Yang, Zhao-Xun Wang
OBJECTIVE: To study the expression of TCR BV CDR3 family in fulminant hepatitis B (FHB) patients. METHODS: Totally 28 patients with fulminant hepatitis B (FHB) (FHB group), who were treated in our hospital from Oct. 2010. to Mar. 2012, and 20 healthy controls( HC group) were included in the study. PBMCs were isolated from anticogulated blood, and RT-PCR was used to detect the levels of TCR BV CDR3 family in the 2 groups. RESULTS: The levels of DeltaCt1, DeltaCt12 and DeltaCt20 in FHB group were higher than those in HC group (P < 0...
August 2013: Chinese Journal of Experimental and Clinical Virology
Domenico Di Raimondo, Antonino Tuttolomondo, Carmelo Buttà, Benedetto Lucifora, Giuseppe Licata, Antonio Pinto
Among the different subtypes of ischaemic strokes, almost 20 % are of cardiac origin. Different are the causes of cardioembolic stroke, but the most common is the atrial fibrillation, a supraventricular arrhythmia. Appropriate use of antiplatelet drugs and anticoagulants after transient ischaemic attack (TIA) or ischaemic stroke depends on whether the underlying cause is cardioembolic or of presumed arterial origin. Adequate antiplatelet therapy is recommended for secondary prevention after cerebral ischaemia of presumed arterial origin, whether for patients with TIA and ischaemic stroke of cardiac origin, mainly due to atrial fibrillation...
November 2013: Current Vascular Pharmacology
Vanessa Roldán, Francisco Marín, Juan G Martínez, Ana García-Herola, Francisco Sogorb, Gregory Y H Lip
Interleukin-6 levels, but not prothrombin fragment 1 + 2, correlates with a point-based score for stroke risk in atrial fibrillation, even after oral anticogulation.
April 1, 2005: American Journal of Cardiology
No abstract text is available yet for this article.
March 1965: Medicinski Arhiv
No abstract text is available yet for this article.
June 1962: La Semaine des Hôpitaux: Thérapeutique
No abstract text is available yet for this article.
November 1, 1958: Revue Médicale de Liège
No abstract text is available yet for this article.
February 1957: A Medicina Contemporânea
No abstract text is available yet for this article.
April 17, 1953: Casopís Lékar̆ů C̆eských
N Magy, M P Algros, E Racadot, H Gil, B Kantelip, J L Dupond
INTRODUCTION: Livedoid vasculopathy is characterized by early, focal painful purpuric lesions of the lower skin extremities without histologic finding of small vessel vasculitis. EXEGESIS: A 38-year-old man was seen in our unit for painful purpuric lesions of both feet localized on toes and external sides. Skin biopsy showed dermic vessel thrombosis and endothelial cell proliferation. Lupus anticogulant antibody was positive in association with a heterozygous factor V (Leiden) gene mutation (G1691A)...
June 2002: La Revue de Médecine Interne
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