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Maria Sofra, Anna Antenucci, Michele Gallucci, Chiara Mandoj, Rocco Papalia, Claudia Claroni, Ilaria Monteferrante, Giulia Torregiani, Valeria Gianaroli, Isabella Sperduti, Luigi Tomao, Ester Forastiere
BACKGROUND: Laparoscopic prostatectomy (LRP) may activate clotting system influencing the risk of perioperative thrombosis in patients with prostate cancer. Moreover, different anaesthetic techniques can also modify coagulant factors. Thus, the aim of this study was to investigate the effects on pro- and anti-coagulant and fibrinolytic factors of two established types of anaesthesia in patients with prostate cancer undergoing elective LRP. METHODS: 102 patients with primary prostate cancer, who underwent conventional LRP or robot-assisted laparoscopic prostatectomy (RALP), were studied and divided into 2 groups to receive total intravenous anesthesia with target-controlled infusion (TIVA-TCI) or balanced inhalation anaesthesia (BAL) prior to surgery...
2014: Journal of Experimental & Clinical Cancer Research: CR
Masahiro Naito, Osamu Taguchi, Tetsu Kobayashi, Takehiro Takagi, Corina N D'Alessandro-Gabazza, Yuki Matsushima, Daniel Boveda-Ruiz, Paloma Gil-Bernabe, Takahiro Matsumoto, Ayshwarya-Lakshmi Chelakkot-Govindalayathil, Masaaki Toda, Atsushi Yasukawa, Osamu Hataji, John Morser, Yoshiyuki Takei, Esteban C Gabazza
Acute lung injury (ALI) is a devastating disease with an overall mortality rate of 30 to 40%. The coagulation/fibrinolysis system is implicated in the pathogenesis of ALI. Thrombin-activatable fibronolysis inhibitor (TAFI) is an important component of the fibrinolysis system. Recent studies have shown that the active form of TAFI can also regulate inflammatory responses by its ability to inhibit complement C3a, C5a, and osteopontin. We hypothesized that TAFI might have a protective role in ALI. To demonstrate this hypothesis, the development of ALI was compared between wild-type (WT) and TAFI-deficient mice...
October 2013: American Journal of Respiratory Cell and Molecular Biology
Whasun Lim, Hee Seung Kim, Wooyoung Jeong, Suzie E Ahn, Jinyoung Kim, Yong Beom Kim, Min A Kim, Mi-Kyung Kim, Hyun Hoon Chung, Yong Sang Song, Fuller W Bazer, Jae Yong Han, Gwonhwa Song
Serine protease inhibitors (SERPINs) appear to be ubiquitously expressed in a variety of species and play important roles in pivotal physiological processes such as angiogenesis, immune responses, blood coagulation and fibronolysis. Of these, squamous cell carcinoma antigen 1 (SCCA1), also known as a SERPINB3, was first identified in squamous cell carcinoma tissue from the cervix of women. However, there is little known about the SERPINB3 expression in human epithelial ovarian cancer (EOC). Therefore, in the present study, we investigated the functional role of SERPINB3 gene in human EOC using chickens, the most relevant animal model...
2012: PloS One
Claire Bardel, Vincent Danjean, Pierre Morange, Emmanuelle Génin, Pierre Darlu
With the increasing availability of genetic data, several SNPs in a candidate gene can be combined into haplotypes to test for association with a quantitative trait. When the number of SNPs increases, the number of haplotypes can become very large and there is a need to group them together. The use of the phylogenetic relationships between haplotypes provides a natural and efficient way of grouping. Moreover, it allows us to identify disease or quantitative trait-related loci. In this article, we describe ALTree-q, a phylogeny-based approach to test for association between quantitative traits and haplotypes and to identify putative quantitative trait nucleotides (QTN)...
December 2009: Genetic Epidemiology
Young-Jun Park, Gang Liu, Yuko Tsuruta, Emmanuel Lorne, Edward Abraham
The urokinase receptor (uPAR) plays an important role in regulation of fibronolysis, cell migration, and adhesion. In this study, we examined whether uPAR plays a role in modulating efferocytosis of neutrophils. Macrophages from uPAR(-/-) mice demonstrated enhanced ability to engulf viable wild-type (WT) neutrophils in vitro and in vivo in the lungs. The increased phagocytic activity of uPAR(-/-) macrophages was abrogated by incubation with soluble uPAR (suPAR), arginine-glycine-aspartic acid (RGD)-containing peptides, or anti-integrin antibodies...
July 23, 2009: Blood
George Mitsiakos, Evaggelia Giougi, Georgia Papaioannou, Paraskevi Karagianni, Emmanouil Papadakis, Nikolaos Nikolaidis
BACKGROUND: Clinical and experimental researches have linked smoking to disturbances of coagulation and fibrinolysis. Several potential mechanisms are incriminated involving inflammation, fibrinogen synthesis and clotting factors. Based on the fact that the majority of tobacco components cross the placental barrier, the objective of our current study is to investigate the influence of smoking during pregnancy on neonatal haemostasis. STUDY DESIGN: The study was based on a comparative evaluation of coagulation and fibronolysis between healthy full term infants of women who smoked during pregnancy and a control group...
2009: Thrombosis Research
No abstract text is available yet for this article.
February 1954: Wiadomości Lekarskie
J B Chek, N I Panchenko
OBJECTIVE: To detect fibrinogen degradation products (FDP) in blood as a result of induced hyperfibrinolysis. DESIGN: This in-vitro and in-vivo study compared the relationship between the plasma FDP levels, the rate of their production, the degree of fibrinolysis and the effect of protease inhibitors in primary hyperfibrinolysis conditions. SETTING: Department of Medical Biochemistry, Kharkov General and Emergency Operational and Research Institute, Ukraine in collaboration with the Department of Biochemistry, University of Nairobi, Kenya...
April 2000: East African Medical Journal
Chasen, Muller
Sudden cardiac death, myocardial infarction, unstable angina, ventricular tachyarrhythmias, fatal pulmonary thromboembolism, rupture of thoracic aorta, and ischemic and hemorrhagic cerebrovascular accidents exhibit a prominent circadian pattern with events more frequently during the morning (0600-1200 h)after awakening. Hematologic processes (e.g. increases in secretion and aggregability of platelets, changes in blood clotting, and fibronolysis), vascular processes (e.g. increase in vascular tone), and hemodynamic processes (e...
February 1998: Blood Pressure Monitoring
S Romano, M Penco, A Dagianti
No abstract text is available yet for this article.
June 1998: Cardiologia: Bollettino Della Società Italiana di Cardiologia
T H Ngo, S Verheyen, I Knockaert, P J Declerck
Plasminogen activator inhibitor-1 (PAI-1) is the primary physiological inhibitor of both tissue-type plasminogen activator (t-PA) and urokinase-type plasminogen activator (u-PA). Elevated plasma levels of PAI-1 have been associated with several important thrombotic diseases. A large number of studies have demonstrated that rats are suitable for in vivo investigations on thrombolysis and fibronolysis. In this study, we have expressed, in Escherichia coli, purified and characterized recombinant rat PAI-1 in comparison with human PAI-1...
July 1997: Journal de Pharmacie de Belgique
L Heilmann, A Kriechbaum, B Hojnacki, V Bode, H Wolf
In a pilot study, 25 patients with histories of repeated abortion were treated by passive immunotherapy with high-dosage immunoglobulin administration (Sandoglobulin). Plasma viscosity, RBC aggregation, hematocrit, PAI, D-dimer and Factor VIIIR:AG were studied in order to detect risks. By September 1, 1992, 16 women had given birth; abortion had recurred in 2 women and 7 were pregnant between the 10th and 37th GW. Five pregnancies terminated in premature/small-for-date births and one neonate had a congenital malformation syndrome...
March 1993: Zeitschrift Für Geburtshilfe und Perinatologie
C V Prowse, J G Douglas, J A Forrest, M L Forsling
Eight patients with cirrhosis were infused with lysine vasopressin (10 microgram LVP) and triglyclylysine vasopressin (750 microgram and 2000 microgram Glypressin, GVP) on separate occasions. LVP infusion resulted in an increase in factor VIII, factor VIII-related antigen and plasminogen activator (PA). The factor VIII antigen: activity ratio decreased following infusion, but factor VIII electrophoretic mobility and in vitro decay rate were unchanged. GVP infusion produced no change in factor VIII or PA. Assay of vasopressin-like antigen and antidiuretic activity showed that GVP is cleaved to LVP in vivo...
February 1980: European Journal of Clinical Investigation
G A Mitchell
No abstract text is available yet for this article.
October 1983: Seminars in Thrombosis and Hemostasis
M Conti, F Marongiu, G Mameli, A M Mamusa, A B Cambuli, E Cossu, G G Sorano, G Biondi, R Cirillo, A Balestrieri
In vivo study of blood coagulation and fibrinolysis activities in non insulin dependent diabetes mellitus. The aim of the study was to investigate in vivo blood coagulation and fibrinolysis activities in a group of diabetic patients NIDDM with and without vascular complications. For this purpose we determined two sensitive indicators in vivo of blood coagulation and fibrinolytic activities such as fibrinopeptide A and B beta 15-42 respectively. Moreover, we computed the ratio between B beta 15-42 and fibrinopeptide A in order to investigate a possible imbalance in vivo between blood coagulation and fibrinolysis...
June 1989: Recenti Progressi in Medicina
G Verron, P Exadaktylos
This article gives a survey of the physiology of blood coagulation in newborn infants, subdivided into the particularities of the plasmic coagulation system and the fibronolysis. Etiology, diagnosis and therapy of the consumption coagulopathy as well as the coagulopathy of production are dealed with.
1976: Zentralblatt Für Chirurgie
S Izaki, S M Goldstein, K Fukuyama, W L Epstein
Patterns of fibrin deposition were investigated by immunofluorescence microscopy in livers of thymus intact (TI) and athymic (AT) mice infected with Schistosoma mansoni. Thrombin and fibrinolysis inhibitor activity in tissue extracts also were measured. In TI mice fibrin was detected perivascularly by 6 weeks after infection and at 8 weeks it was found over the granulomas as they developed. Fibrin was cleared from the center of granulomas by 10 weeks. Thrombin inhibitor activity increased at 4 to 6 weeks but declined below control levels later as granulomas formed...
December 1979: Journal of Investigative Dermatology
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