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Inflammatory Issues related to Crohn's Disease

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https://www.readbyqxmd.com/read/28161290/safety-of-treatments-for-inflammatory-bowel-disease-clinical-practice-guidelines-of-the-italian-group-for-the-study-of-inflammatory-bowel-disease-ig-ibd
#1
Livia Biancone, Vito Annese, Sandro Ardizzone, Alessandro Armuzzi, Emma Calabrese, Flavio Caprioli, Fabiana Castiglione, Michele Comberlato, Mario Cottone, Silvio Danese, Marco Daperno, Renata D'Incà, Giuseppe Frieri, Walter Fries, Paolo Gionchetti, Anna Kohn, Giovanni Latella, Monica Milla, Ambrogio Orlando, Claudio Papi, Carmelina Petruzziello, Gabriele Riegler, Fernando Rizzello, Simone Saibeni, Maria Lia Scribano, Maurizio Vecchi, Piero Vernia, Gianmichele Meucci
Inflammatory bowel diseases are chronic conditions of unknown etiology, showing a growing incidence and prevalence in several countries, including Italy. Although the etiology of Crohn's disease and ulcerative colitis is unknown, due to the current knowledge regarding their pathogenesis, effective treatment strategies have been developed. Several guidelines are available regarding the efficacy and safety of available drug treatments for inflammatory bowel diseases. Nevertheless, national guidelines provide additional information adapted to local feasibility, costs and legal issues related to the use of the same drugs...
January 17, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28099821/medication-non-adherence-in-adult-patients-affected-by-inflammatory-bowel-disease-a-critical-review-and-update-of-the-determining-factors-consequences-and-possible-interventions
#2
Marco Vincenzo Lenti, Christian P Selinger
Achieving adherence to medications can be a serious challenge for patients affected by inflammatory bowel disease (IBD). Medical treatment is fundamental for inducing and maintaining remission, preventing flares and reducing the risk of colorectal cancer. Non-adherence may affect patients' quality of life resulting in unfavourable treatment outcomes, more hospitalizations and higher healthcare-related costs. Recognising and improving adherence is therefore a primary aim for the treatment of IBD. Areas covered: We critically discuss the current knowledge on medication non-adherence in adult patients affected by IBD, also mentioning a few issues concerning the paediatric and adolescent populations...
March 2017: Expert Review of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/28092152/issues-in-nutrition-dietary-considerations-in-select-chronic-conditions
#3
Margaret E Thompson, Mary Barth Noel
Chronic diseases that affect the gastrointestinal tract also tend to affect nutrition. The incidence of chronic liver disease is increasing. As the prevalence of obesity rises, so do the incidences of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. Patients with chronic liver disease usually have some degree of malnutrition. In the absence of encephalopathy, patients with chronic liver disease should consume more protein than that in the average diet. There is some controversy about whether diet plays a role in the development of inflammatory bowel disease...
January 2017: FP Essentials
https://www.readbyqxmd.com/read/27899522/care-of-inflammatory-bowel-disease-patients-in-remission
#4
REVIEW
Charumathi Raghu Subramanian, George Triadafilopoulos
Inflammatory bowel disease (IBD) comprises two distinct conditions: ulcerative colitis and Crohn's disease, both of which are chronic, relapsing disorders carrying significant morbidity, mortality and healthcare costs. With growing attention to coordinated healthcare for patients with chronic systemic diseases, this review focuses on the care of IBD patients in remission, their concerns, quality of life, follow-up, the role of primary care physicians and the IBD-specific aspects of long-term care. We did an extensive PubMed search for articles pertaining to IBD patients in remission and, along with the authors' experience, formulated a comprehensive review...
November 2016: Gastroenterology Report
https://www.readbyqxmd.com/read/27889728/pediatric-inflammatory-bowel-disease
#5
Akshay Kapoor, Vidyut Bhatia, Anupam Sibal
Background: The incidence of inflammatory bowel disease is increasing in the pediatric population worldwide. NEED AND PURPOSE OF REVIEW: There is paucity of high quality scientific data regarding pediatric inflammatory bowel disease. Most of the guidelines are offshoots of work done in adults, which have been adapted over time to diagnose and treat pediatric patients. This is in part related to the small numbers in pediatric inflammatory bowel disease and less extensive collaboration for multicentric trials both nationally and internationally...
November 15, 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/27698900/anti-inflammatory-and-antitumor-activity-of-a-triple-therapy-for-a-colitis-related-colorectal-cancer
#6
Gabriela Figueroa-González, Verónica García-Castillo, Jossimar Coronel-Hernández, Eduardo López-Urrutia, Sonia León-Cabrera, Luis E Arias-Romero, L I Terrazas, Miriam Rodríguez-Sosa, Alma Delia Campos-Parra, Eduardo Zúñiga-Calzada, Cesar Lopez-Camarillo, Fermín Morales-González, Nadia J Jacobo-Herrera, Carlos Pérez-Plasencia
Colorectal cancer (CRC) is an important health issue worldwide, accounting for the third place of cancer incidence. Chronic inflammation, as seen in Crohn's disease and ulcerative colitis, is the most important risk factor for developing CRC, as it favours neoplastic transformation by enhancing epithelial cell turnover in the colonic mucosa. Treatments for CRC need to be improved; currently they are not specific and have several secondary effects in patients. The main objective of this work was to evaluate a new therapeutic strategy against a colitis-related colorectal cancer in vivo and in vitro by targeting mTOR-signaling and lactate dehydrogenase A...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27602237/infertility-in-men-with-inflammatory-bowel-disease
#7
REVIEW
Takeshi Shin, Hiroshi Okada
Inflammatory bowel disease (IBD) predominantly affects young adults. Fertility-related issues are therefore important in the management of patients with IBD. However, relatively modest attention has been paid to reproductive issues faced by men with IBD. To investigate the effects of IBD and its treatment on male fertility, we reviewed the current literature using a systematic search for published studies. A PubMed search were performed using the main search terms "IBD AND male infertility", "Crohn's disease AND male infertility", "ulcerative colitis AND male infertility"...
August 6, 2016: World Journal of Gastrointestinal Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27518699/macrophage-tolerance-in-the-gut-it-is-in-the-epigenome
#8
Joachim L Schultze
Intestinal macrophages are functionally specialized to phagocytose bacteria, including harmful and invading pathogens, without releasing pro-inflammatory mediators. This unique functional combination guarantees an optimal defense against millions of gut bacteria while at the same time protecting the host from inflammation-related tissue damage. IL-10 seems to be a critical tissue factor involved in this balance and deficiencies in IL-10 in humans and mice have been shown to deteriorate this fine balance, leading to chronic inflammation and diseases such as Crohn's disease...
August 2016: European Journal of Immunology
https://www.readbyqxmd.com/read/27189912/negative-effects-on-psychological-health-and-quality-of-life-of-genuine-irritable-bowel-syndrome-type-symptoms-in-patients-with-inflammatory-bowel-disease
#9
David J Gracie, Christopher J M Williams, Ruchit Sood, Saqib Mumtaz, M Hassan Bholah, P John Hamlin, Alexander C Ford
BACKGROUND & AIMS: Symptoms compatible with irritable bowel syndrome (IBS) are common in patients with inflammatory bowel disease (IBD), but it is unclear whether this relates to occult IBD activity. We attempted to resolve this issue in a secondary care population by using a cross-sectional study design. METHODS: We analyzed Rome III IBS symptoms, disease activity indices, and psychological, somatization, and quality of life data from 378 consecutive, unselected adult patients with IBD seen in clinics at St James's University Hospital in Leeds, United Kingdom from November 2012 through June 2015...
May 14, 2016: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27182211/fertility-and-contraception-in-women-with-inflammatory-bowel-disease
#10
Jason Martin, Sunanda V Kane, Linda A Feagins
Inflammatory bowel disease (IBD) carries a high burden in women during their reproductive years, and family planning issues are often a significant cause of concern. Fertility is normal in women with nonsurgically treated ulcerative colitis and similar or slightly reduced in women with Crohn's disease. Women who undergo ileal pouch anastomosis have reduced fertility. Fertility is likely worsened by disease activity but unaffected by medications used to treat IBD. Infertile patients with IBD respond as well as non-IBD patients to in vitro fertilization (IVF)...
February 2016: Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27117934/a-survey-of-people-with-inflammatory-bowel-disease-to-investigate-their-views-of-food-and-nutritional-issues
#11
L Kinsey, S Burden
Survey aims were to investigate the dietary concerns, beliefs and opinions of people with inflammatory bowel disease (IBD), and differences between those with Crohn's disease (CD) or ulcerative colitis (UC). A cross-sectional postal questionnaire was sent to people with IBD who were booked into an adult IBD or Gastroenterology clinic over a 6-week period. There were 416 eligible people and 168 (40%) responded. Sixty-four (42%) people indicated that food affects their symptoms a lot or severely. Eighty (51%) respondents indicated that diet was important or extremely important in controlling symptoms...
July 2016: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/27110305/demographic-characteristics-of-children-with-early-clinical-manifestation-of-inflammatory-bowel-disease
#12
Edyta Szymańska, Sylwia Szymańska, Michał Szczepański, Piotr Landowski, Grażyna Czaja-Bulsa, Elżbieta Jarocka-Cyrta, Bartosz Korczowski, Elżbieta Krzesiek, Jarosław Kierkuś
INTRODUCTION: Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), is a chronic condition of the colon and small intestine. The disease is common in young people (children and young adults), but it is rare in children younger than five years of age. Therefore, IBD developing during the first years of life (under the age of 5) is known as an early-onset IBD (EO-IBD), and it is considered to be a specific entity with a distinct phenotype. However, the available data on that issue are still insufficient...
2016: Przegla̜d Gastroenterologiczny
https://www.readbyqxmd.com/read/26849125/the-association-of-mycobacterium-avium-subsp-paratuberculosis-with-inflammatory-bowel-disease
#13
Verlaine J Timms, George Daskalopoulos, Hazel M Mitchell, Brett A Neilan
The association of Mycobacterium avium subspecies paratuberculosis (M. paratuberculosis) with Crohn's disease is a controversial issue. M. paratuberculosis is detected by amplifying the IS900 gene, as microbial culture is unreliable from humans. We determined the presence of M. paratuberculosis in patients with Crohn's disease (CD) (n = 22), ulcerative colitis (UC) (n = 20), aphthous ulcers (n = 21) and controls (n = 42) using PCR assays validated on bovine tissue. Culture from human tissue was also performed...
2016: PloS One
https://www.readbyqxmd.com/read/26752468/patients-with-refractory-crohn-s-disease-successfully-treated-with-ustekinumab
#14
Kimberly A Harris, Sara Horst, Akash Gadani, Anne Nohl, Kim Annis, Caroline Duley, Dawn Beaulieu, Leyla Ghazi, David A Schwartz
BACKGROUND: Ustekinumab is a new biologic therapy targeting interleukin-12 and interleukin -23. It is currently approved for the treatment of psoriasis, but clinical trials have shown that it can induce and maintain remission in Crohn's disease (CD). We aim to evaluate effectiveness of ustekinumab in the treatment of CD. METHODS: A retrospective chart review was performed including patients (pts) from 2 academic medical centers with complicated, refractory CD started on ustekinumab between June 2011 and June 2014...
February 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/26561025/-modern-mri-of-the-small-bowell
#15
REVIEW
M Scharitzer, A Ba-Ssalamah
CLINICAL METHODOLOGICAL ISSUES: The radiological diagnostics of diseases of the small intestine have undergone a great change in the last two decades. Through rapid progress with new treatments and an increasing therapeutic focus on transmural healing, a complete evaluation of the gastrointestinal tract is now crucial. STANDARD RADIOLOGICAL METHODS: With the introduction of endoscopy, gastrointestinal imaging with a relatively high radiation exposure had only limited applications...
December 2015: Der Radiologe
https://www.readbyqxmd.com/read/26535125/inflammatory-bowel-disease-specific-pregnancy-knowledge-of-gastroenterologists-against-general-practitioners-and-obstetricians
#16
Soleiman B Kashkooli, Jane M Andrews, Matthew B Roberts, Christian P Selinger, Rupert W Leong
BACKGROUND: Patients with inflammatory bowel disease (IBD) tend to have smaller family sizes. Health care professionals (HCPs) may inadvertently provide inaccurate advice to patients resulting in voluntary childlessness or unfavourable pregnancy outcomes. OBJECTIVE: The study aims to objectively measure IBD-specific pregnancy-related knowledge of general practitioners (GPs) and obstetricians/gynaecologists (OB/GYNs) in comparison with gastroenterologists (GEs) using the validated Crohn's and Colitis Pregnancy Knowledge (CCPKnow) questionnaire...
October 2015: United European Gastroenterology Journal
https://www.readbyqxmd.com/read/26367373/management-of-ibd-patients-with-current-immunosuppressive-therapy-and-concurrent-infections
#17
Jean-François Rahier
In an era of increasing use of immunomodulator therapy and biologics, opportunistic infections (OI) have emerged as a pivotal safety issue in patients with inflammatory bowel disease (IBD). Clinical studies, registries and case reports warn about the increased risk for infections, particularly OIs. Today, the challenge for a physician is not only to manage IBD, but also to recognize, prevent and treat common and uncommon infections. The 2014 European Crohn's and Colitis Organisation (ECCO) guidelines on the management and prevention of OIs in patients with IBD provide clinicians with guidance on the prevention, detection and management of OIs...
September 14, 2015: Digestive Diseases
https://www.readbyqxmd.com/read/26168332/heterogeneity-of-subordination-of-the-il-18-ifn-%C3%AE-axis-to-caspase-1-among-patients-with-crohn-s-disease
#18
Anne Jarry, Céline Bossard, Laure Droy-Dupré, Christelle Volteau, Arnaud Bourreille, Guillaume Meurette, Jean-François Mosnier, Christian L Laboisse
In Crohn's disease (CD), hierarchical architecture of the inflammatory network, including subordination of IL-18, an IFN-γ-inducing cytokine, to the inflammasome, have remained undeciphered. Heterogeneity among patients of such a subordination cannot be evaluated by animal models, monofactorial in their etiology and homogenous in disease progression. To address these issues, we set up an ex vivo model of inflamed mucosa explant cultures from patients with active long-standing CD. Th1 cytokine production, especially IFN-γ and IL-18, was assessed in relation with inflammation intensity...
October 2015: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/26111098/the-lived-experience-of-adults-with-ulcerative-colitis
#19
Jacqueline Sammut, Josianne Scerri, Rita Borg Xuereb
AIMS AND OBJECTIVES: The purpose of this study was to explore the experiences of adults living with ulcerative colitis. BACKGROUND: Research to date has focused on the impact of inflammatory bowel disease, by analysing the responses of persons with ulcerative colitis and Crohn's disease collectively. This article addresses the dearth in literature by exploring the experiences of adults living with ulcerative colitis. DESIGN: An exploratory qualitative phenomenological design was used...
September 2015: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/26089868/optimizing-the-care-and-health-of-women-with-inflammatory-bowel-disease
#20
REVIEW
Judy Nee, Joseph D Feuerstein
Inflammatory bowel disease (IBD) including both ulcerative colitis and Crohn's disease is increasing worldwide. Although diagnosis is equally found in men and women, the chronicity of IBD poses a unique impact on the milestones of a woman's life. As the gastroenterologist becomes increasingly important in the health maintenance of patients with IBD, this review stresses the unique gender issues in women with IBD related to menstruation, cervical cancer, sexual health, contraception, and menopause that may affect the course of disease, treatment decisions, and quality of life...
2015: Gastroenterology Research and Practice
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